CN105194224A - Pharmaceutical composition for treating nausea and vomiting caused by anaesthesia - Google Patents
Pharmaceutical composition for treating nausea and vomiting caused by anaesthesia Download PDFInfo
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Abstract
A related pharmaceutical composition for treating nausea and vomiting caused by anaesthesia is composed of the following traditional Chinese medicine raw materials in parts by weight: 5-8 parts of Indian rorippa herb, 8-10 parts of daidaihua, 10-15 parts of lemon leaf, 3-7 parts of fructus piperis longi, 3-5 parts of all-grass of pedunculate trigonotis, 2-5 parts of mongollian thyme herb, 5-8 parts of root-bark of ovate catalpa, 7-10 parts of twoflower micromeria, 8-10 parts of trifoliate acanthopanax root or root-bark, 5-10 parts of galium verum L., 5-15 parts of Japanese polypody rhizome, 3-7 parts of root and rhizome of canton fairybells, 3-7 parts of asterias rollestoni bell and asterias amurensis lutken, 2-5 parts of littleleaf indianmulberry, 4-8 parts of Yunnan dutchmanspipe rhizome, 2-7 parts of pummelo pericarp, and 2-5 parts of fructus viticis negundo. The pharmaceutical composition possesses efficacies of pacifying liver and regulating qi, warming middle to harmonize stomach, clearing heat and detoxifying, promoting digestion and stopping vomit, is substantial in curative effect on nausea and vomiting caused by anaesthesia, and is safe and free of toxic and side effects.
Description
Technical field
The invention belongs to the field of Chinese medicines, be specifically related to a kind of pharmaceutical composition being used for the treatment of the nausea and vomiting that anesthesia causes.
Background technology
Situation, the operation of Post operation generation Nausea and vomiting and patient and anaesthetize all relevant.Show according to statistics, women, significantly higher than male, may raise relevant with patient's adult female blood plasma inner estrogen and progesterone levels, and man, daughter is virgin then without this difference; The probability that PONV occurs children's is higher, especially the highest with school age population than adult; Within more than 70 years old, person's incidence rate is significantly lower than year the lighter, all can't bear to enliven relevant with the various reflection of old people; Adiposis patient, higher than general adult, lodges in more in fatty tissue because of Inhalation Anesthetic and the remaining medicine of gastric is more relevant.
Anesthesia is the one of the main reasons of nausea and vomiting, relevant with the characteristic, depth of anesthesia etc. of anesthetics.Anaesthesia dosage is larger, and incidence of nausea and vomiting is higher, and the surgery anesthesia time is longer, and incidence of nausea and vomiting is higher.Anesthesia duration continues 30 ~ 90min, and postoperative nausea and vomiting incidence rate is 17%, if anesthesia duration continues 150 ~ 200min, then incidence of nausea and vomiting is increased to 46%, may be relevant with anesthetics total amount.
At present, to anaesthetize the nausea and vomiting common drug that causes as follows in treatment:
(1) anticholinergic agent: comprise atropine, scopolamine etc., mainly acts on labyrinthine system, is therefore mainly used in " motion sickness ".
(2) antihistaminic: except promethazine, antihistaminic mainly acts on vestibular system, and very micro-to the effect of chemoceptor sensitizing range, promethazine is an effective preventative Antiemetics, but recovery from anesthesia can be caused postpone, especially still can cause xerostomia and delirium elderly patients.
(3) butyrophenones: be stronger dopamine (D2) receptor antagonist.Droperidol has been widely used in the treatment of nausea and vomiting.Haloperidol both can be used for prevention and also can be used for treatment, 30min onset after intramuscular injection, continued 3h.Droperidol is similar with the effect of haloperidol, and onset is slow, and the persistent period is long, and its side effect all can cause cone vitro reactions, hypotension and calmness etc.
Summary of the invention
The object of the present invention is to provide the pharmaceutical composition being used for the treatment of the nausea and vomiting that anesthesia causes that a kind of effective percentage is high, have no side effect.
The technical solution adopted for the present invention to solve the technical problems is: a kind of pharmaceutical composition being used for the treatment of the nausea and vomiting that anesthesia causes,: Herba Rorippae 5-8 part is formed by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 8-10 part, Folium Citri Limoniae 10-15 part, Fructus Piperis Longi 3-7 part, Herba Trigonotidis peduncularis 3-5 part, Herba Thymi 2-5 part, Cortex catalpae ovatae radicis 5-8 part, Herba Micromeriae Biflorae 7-10 part, Radix Acanthopanacis Trifoliati 8-10 part, Herba galii veri 5-10 part, Rhizoma Polypodiodis Nipponicae 5-15 part, Radix et Rhizoma Dispori Cantoniensis 3-7 part, starfish 3-7 part, Herba Morindae Parvifoliae 2-5 part, Radix Aristolochiae yunnanensis 4-8 part, Pericarpium Citri grandis 2-7 part, Fructus Viticis Negundo 2-5 part.
Preferably, a kind of pharmaceutical composition being used for the treatment of the nausea and vomiting that anesthesia causes, forms: Herba Rorippae 5 parts by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 10 parts, Folium Citri Limoniae 10 parts, Fructus Piperis Longi 5 parts, Herba Trigonotidis peduncularis 4 parts, Herba Thymi 5 parts, Cortex catalpae ovatae radicis 7 parts, Herba Micromeriae Biflorae 8 parts, Radix Acanthopanacis Trifoliati 8 parts, Herba galii veri 9 parts, Rhizoma Polypodiodis Nipponicae 10 parts, Radix et Rhizoma Dispori Cantoniensis 5 parts, starfish 5 parts, Herba Morindae Parvifoliae 4 parts, Radix Aristolochiae yunnanensis 5 parts, Pericarpium Citri grandis 6 parts, Fructus Viticis Negundo 5 parts.
The pharmacologically active of each raw material of Chinese medicine of the present invention is as follows:
Herba Rorippae is that thing Herba Rorippae and the herb without lobe Han are planted, acrid in the mouth by ten Zi Hua sections, and bitter, slightly warm in nature, returns lung, Liver Channel, expelling phlegm for arresting cough; Induce sweat cold expelling; Promoting blood circulation and detoxication; Dampness removing jaundice eliminating.Main cough phlegm dyspnea; Cold, fever; Measles is sent out not smooth thoroughly; Rheumatic arthralgia; Laryngopharynx swelling and pain; Furuncle carbuncle; Dermatitis rhus; Amenorrhea; Traumatic injury; Jaundice; Edema.
Citrus aurantium L. var. amara Engl. is the alabastrum of Folium Symplocoris Caudatae profit plant Citrus aurantium L. var. amara Engl., pungent, sweet, micro-hardship, and property is put down, the chest stuffiness relieving of regulating the flow of vital energy; Stomach function regulating preventing or arresting vomiting.It is main that painful abdominal mass is vexed in the heart; Abdominal distention; Anorexia; Nausea and vomiting." decoction pieces is newly joined ": the chest stuffiness relieving of regulating the flow of vital energy, appetizing preventing or arresting vomiting.
Folium Citri Limoniae is the leaf of rutaceae Canton lemon or lemon, pungent, sweet, micro-hardship, and tepor, returns lung, stomach, large intestine channel, preventing phlegm from forming and stopping coughing; Regulating qi-flowing for harmonizing stomach; Antidiarrheal.Main cough with asthma abundant expectoration; Stagnation of QI abdominal distention; Have loose bowels.
Fructus Piperis Longi is the immaturity fruit ear of Piperaceae plant Fructus Piperis Longi, pungent, and heat, returns stomach, large intestine channel, warming spleen and stomach for dispelling cold, therapeutic method to keep the adverse QI flowing downwards pain relieving.For coldness and pain in the epigastrium, vomiting, has loose bowels, migraine; External treatment is had a toothache.
Herba Trigonotidis peduncularis is the herb of comfrey Herba Trigonotidis peduncularis, sweet, acrid, warm, warming middle-JIAO stomach invigorating, reducing swelling and alleviating pain, hemostasis.For stomachache, acid regurgitation, spits blood; Traumatic injury is controlled in external, fracture.
Herba Thymi is the thymic herb of labiate, acrid in the mouth, temperature, warming spleen and stomach for dispelling cold, wind dispelling pain relieving.Control tell inverse, stomachache, have loose bowels, lack of appetite painful abdominal mass is swollen, cough due to wind and cold, and pharyngeal swelling is had a toothache, general pain, skin pruritus.
Cortex catalpae ovatae radicis is the root bark of Bignoniaceae plant Chinese catalpa or the phloem of bark, and bitter in the mouth is cold in nature, returns gallbladder, stomach warp, clearing away heat-damp and promoting diuresis; Sending down the abnormal ascending QI emesis; Killing parasites for relieving itching.Main jaundice due to damp-heat; The inverse vomiting of stomach; Skin ulcer scabies; Eczema; Skin pruritus.
Herba Micromeriae Biflorae is the herb of labiate Herba Micromeriae Biflorae, and bitter in the mouth is pungent, warm in nature, expelling cold and relieving exterior syndrome; Stomach invigorating in wet; Removing dampness removing food stagnancy.Main anemofrigid cold; Cold syndrome of the stomach gastralgia; Abdominal distention; Nausea and vomiting; Have loose bowels; Dysentery; Lump in the abdomen; Colic of cold type.
Radix Acanthopanacis Trifoliati is root or the root bark of the white Jin of Araliaceae, and toil is cool, heat-clearing and toxic substances removing, expelling wind and removing dampness, relaxing muscles and tendons to promote blood circulation.Cure cold high heat, cough with blood-flecked phlegm, rheumatic arthritis, jaundice, leucorrhea, lithangiuria, traumatic injury, furuncle and phyma skin infection.
Herba galii veri is the herb of Maguireothamnus speciosus Herba galii veri, micro-pungent, bitter, is slightly cold, heat-clearing and toxic substances removing; Promoting blood circulation to restore menstrual flow; Dispelling wind for relieving itching.Main hepatitis; Ascites; Laryngopharynx swelling and pain; Furuncle toxic swelling; Traumatic injury; Women's amenorrhea; Leukorrhagia; Venom; Honor measles; Paddy field dermatitis.
Rhizoma Polypodiodis Nipponicae is the rhizome of Plants of Polypodiaceae Rhizoma Polypodiodis Nipponicae, bitter, cool, GUIXIN, liver, lung meridian, clearing away heat-damp and promoting diuresis; Promoting blood circulation to remove obstruction in the collateral.Main acute diseases such as cholera and sunstroke stranguria with turbid discharge; Have loose bowels; Rheumatic arthralgia; Traumatic injury." Chinese Herbal Medicine in Xinjiang handbook ": " heat-clearing and toxic substances removing, suppressing the hyperactive liver improving eyesight.Control urinary tract infection, enteritis, infantile hyperpyrexia infantile convulsion.″
Radix et Rhizoma Dispori Cantoniensis is the root and rhizome of liliaceous plant Guangdong cantonese fairy bells, and bitter in the mouth is pungent, cool in nature, heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation.Control hyperpyrexia, asthenia osteopyrexia and fever, rheumatism is benumbed, joint lumbago and skelalgia, dysmenorrhea, menorrhagia, carbuncle furuncle, traumatic injury, fracture.
Starfish is the entirety of Asteriidae animal asterias rollestoni, Asterias amurensis, salty in the mouth, and property is put down, and returns liver, stomach warp, checking hyperfunction of the liver for relieving convulsion; Anti-acid and regulating stomach; Heat-clearing and toxic substances removing.Main epilepsy; Stomachache acid regurgitation; Thyromegaly; Otitis media.
Herba Morindae Parvifoliae is the Herb of dicotyledon medicine Maguireothamnus speciosus spire Radix Morindae Officinalis, sweet, cool, returns lung meridian, heat-clearing and toxic substances removing; Eliminating stasis to stop pain; Stomach function regulating removing dampness.Main cold cough; Pertussis; Dyspepsia; Eczema; Traumatic injury, lumbar muscle strain.
Radix Aristolochiae yunnanensis is the root of aristolochiaceae plant Yunnan Fructus Aristolochiae, bitter, and temperature, warming middle-JIAO is regulated the flow of vital energy, and pain relieving helps digestion, relaxing muscles and tendons and activating QI and blood in the collateral.Control gastritis, abdominal distention, stomachache, rheumatic ostalgia." choosing of Yunnan Chinese herbal medicine ": " invigorating the stomach and promoting digestion, cold expelling is regulated the flow of vital energy, pain relieving.Control gastritis, abdominal distention, stomachache, dyspepsia, biliary colic.″
Pericarpium Citri grandis is the peel of Citrus paradisi Macfadyen, pungent, bitter, sweet, temperature, and return spleen, kidney, urinary bladder channel, alleviating distention in middle-JIAO is regulated the flow of vital energy; Help digestion; Reduce phlegm; Relieving cough and asthma.Main stagnation of QI breast is vexed; Coldness and pain in the epigastrium; Food stagnation; Dysentery; Cough with asthma; Hernia.
Fructus Viticis Negundo is the fruit of Verbenaceae five-leaved chaste tree, acrid in the mouth, bitter, warm in nature, returns lung, stomach, Liver Channel, expelling pathogenic wind from the body surface, relieving cough and asthma; To regulate the flow of vital energy the pain relieving that helps digestion.Main Common Cold; Cough; Asthma; Stomachache acid regurgitation; Dyspepsia; Food stagnation dysentery; Cholecystitis, cholelithiasis; Hernia.
The present invention has following beneficial effect: pharmaceutical composition of the present invention has that suppressing the hyperactive liver is regulated the flow of vital energy, warming middle-JIAO for easing the stomach, heat-clearing and toxic substances removing, the emesis that helps digestion effect, to anaesthetizing, the nausea and vomiting caused is evident in efficacy, safe without toxic side effect.
Detailed description of the invention
Be below specific embodiments of the invention, technical scheme of the present invention is described further, but protection scope of the present invention is not limited to these embodiments.Every do not deviate from the present invention's design change or equivalent substituting include within protection scope of the present invention.
Embodiment 1
Be used for the treatment of a pharmaceutical composition of anaesthetizing the nausea and vomiting caused, form: Herba Rorippae 5g by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 10g, Folium Citri Limoniae 10g, Fructus Piperis Longi 5g, Herba Trigonotidis peduncularis 4g, Herba Thymi 5g, Cortex catalpae ovatae radicis 7g, Herba Micromeriae Biflorae 8g, Radix Acanthopanacis Trifoliati 8g, Herba galii veri 9g, Rhizoma Polypodiodis Nipponicae 10g, Radix et Rhizoma Dispori Cantoniensis 5g, starfish 5g, Herba Morindae Parvifoliae 4g, Radix Aristolochiae yunnanensis 5g, Pericarpium Citri grandis 6g, Fructus Viticis Negundo 5g.
Embodiment 2
Be used for the treatment of a pharmaceutical composition of anaesthetizing the nausea and vomiting caused, form: Herba Rorippae 6g by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 9g, Folium Citri Limoniae 13g, Fructus Piperis Longi 4g, Herba Trigonotidis peduncularis 4g, Herba Thymi 3g, Cortex catalpae ovatae radicis 5g, Herba Micromeriae Biflorae 10g, Radix Acanthopanacis Trifoliati 9g, Herba galii veri 10g, Rhizoma Polypodiodis Nipponicae 8g, Radix et Rhizoma Dispori Cantoniensis 3g, starfish 6g, Herba Morindae Parvifoliae 5g, Radix Aristolochiae yunnanensis 4g, Pericarpium Citri grandis 7g, Fructus Viticis Negundo 3g.
Embodiment 3
Be used for the treatment of a pharmaceutical composition of anaesthetizing the nausea and vomiting caused, form: Herba Rorippae 7g by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 9g, Folium Citri Limoniae 12g, Fructus Piperis Longi 7g, Herba Trigonotidis peduncularis 5g, Herba Thymi 2g, Cortex catalpae ovatae radicis 6g, Herba Micromeriae Biflorae 9g, Radix Acanthopanacis Trifoliati 10g, Herba galii veri 5g, Rhizoma Polypodiodis Nipponicae 15g, Radix et Rhizoma Dispori Cantoniensis 6g, starfish 3g, Herba Morindae Parvifoliae 3g, Radix Aristolochiae yunnanensis 8g, Pericarpium Citri grandis 5g, Fructus Viticis Negundo 4g.
Embodiment 4
Be used for the treatment of a pharmaceutical composition of anaesthetizing the nausea and vomiting caused, form: Herba Rorippae 8g by the raw material of Chinese medicine of following weight proportioning, Citrus aurantium L. var. amara Engl. 8g, Folium Citri Limoniae 15g, Fructus Piperis Longi 3g, Herba Trigonotidis peduncularis 3g, Herba Thymi 4g, Cortex catalpae ovatae radicis 8g, Herba Micromeriae Biflorae 7g, Radix Acanthopanacis Trifoliati 10g, Herba galii veri 7g, Rhizoma Polypodiodis Nipponicae 5g, Radix et Rhizoma Dispori Cantoniensis 7g, starfish 7g, Herba Morindae Parvifoliae 2g, Radix Aristolochiae yunnanensis 6g, Pericarpium Citri grandis 7g, Fructus Viticis Negundo 2g.
Clinical data
Physical data: with medicine composite for curing of the present invention be diagnosed as anaesthetize cause nausea and vomiting patient 178 example, wherein male 85 example, women 93 example, age 17-68 year, 44 years old mean age.
Therapeutic Method: pharmaceutical composition of the present invention is decocted in water for oral dose, every day potion, one day twice, sooner or later sub-service.
Curative effect judging standard:
Cure: the clinical symptoms such as Nausea and vomiting all disappear, and physical recovery is normal;
Effective: clinical symptoms takes a turn for the better, and health is clearly better;
Invalid: clinical symptoms has no improvement.
Therapeutic outcome: through the treatment of 1-3 days, 178 routine patients cure 139 examples, effective 35 examples, and invalid 4 examples, cure rate 78.1%, total effective rate 97.8%, bad side reaction does not appear in this patient of therapeutic process.
Model case 1
Huang, 50 years old, with the capable subarachnoid anesthesia of bupivacaine after fracture, aerofluxus, without gastrointestinal decompression, there is nausea and vomiting in man.With medicine composite for curing of the present invention after 1 day symptom significantly alleviate, continual cure one day nausea and vomiting symptom all disappears.
Model case 2
The Qin, 43 years old, out there is nausea from operating room after cholelithiasis Minimally Invasive Surgery in female, see light or make a movement a little and will feel sick, after taking pharmaceutical composition of the present invention two doses, symptom all disappears.
Claims (2)
1. be used for the treatment of a pharmaceutical composition of anaesthetizing the nausea and vomiting caused, it is characterized in that, be made up of the raw material of Chinese medicine of following weight proportioning: Herba Rorippae 5-8 part, Citrus aurantium L. var. amara Engl. 8-10 part, Folium Citri Limoniae 10-15 part, Fructus Piperis Longi 3-7 part, Herba Trigonotidis peduncularis 3-5 part, Herba Thymi 2-5 part, Cortex catalpae ovatae radicis 5-8 part, Herba Micromeriae Biflorae 7-10 part, Radix Acanthopanacis Trifoliati 8-10 part, Herba galii veri 5-10 part, Rhizoma Polypodiodis Nipponicae 5-15 part, Radix et Rhizoma Dispori Cantoniensis 3-7 part, starfish 3-7 part, Herba Morindae Parvifoliae 2-5 part, Radix Aristolochiae yunnanensis 4-8 part, Pericarpium Citri grandis 2-7 part, Fructus Viticis Negundo 2-5 part.
2. be a kind ofly as claimed in claim 1 used for the treatment of the pharmaceutical composition of nausea and vomiting of anaesthetizing and causing, by following weight proportioning raw material of Chinese medicine form: Herba Rorippae 5 parts, Citrus aurantium L. var. amara Engl. 10 parts, Folium Citri Limoniae 10 parts, Fructus Piperis Longi 5 parts, Herba Trigonotidis peduncularis 4 parts, Herba Thymi 5 parts, Cortex catalpae ovatae radicis 7 parts, Herba Micromeriae Biflorae 8 parts, Radix Acanthopanacis Trifoliati 8 parts, Herba galii veri 9 parts, Rhizoma Polypodiodis Nipponicae 10 parts, Radix et Rhizoma Dispori Cantoniensis 5 parts, starfish 5 parts, Herba Morindae Parvifoliae 4 parts, Radix Aristolochiae yunnanensis 5 parts, Pericarpium Citri grandis 6 parts, Fructus Viticis Negundo 5 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105343833A (en) * | 2015-12-04 | 2016-02-24 | 郑路 | Pharmaceutical composition for treating bronchopneumonia |
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Patent Citations (4)
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| CN103961634A (en) * | 2014-06-02 | 2014-08-06 | 王尚 | Traditional Chinese medicine preparation for treating nausea and vomiting caused by anesthesia and preparation method thereof |
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Application publication date: 20151230 |