CN105191945A - Bactericidal composition containing difenoconazole and dithianon - Google Patents
Bactericidal composition containing difenoconazole and dithianon Download PDFInfo
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- CN105191945A CN105191945A CN201410279248.6A CN201410279248A CN105191945A CN 105191945 A CN105191945 A CN 105191945A CN 201410279248 A CN201410279248 A CN 201410279248A CN 105191945 A CN105191945 A CN 105191945A
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- dithianon
- difenoconazole
- bactericidal composition
- composition containing
- water dispersible
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Abstract
The invention belongs to the technical field of pesticides and relates to a compound bactericidal composition containing difenoconazole and dithianon. The bactericidal composition is applied to treatment of diseases of vegetables or fruit trees and is characterized in that the composition contains 1-45% of difenoconazole and 10-85% of dithianon, and an assistant packing is added to prepare water dispersible granules. The bactericidal composition aims at solving the existing problems, is high in energy efficiency, low in pollution, low in cost and wide in bactericidal spectrum and uses the dithianon and the difenoconazole as basic active ingredients.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of containing Difenoconazole and the composite application of bactericidal composition on vegetables or fruit diseases of dithianon.
Background technology
Dithianon (dithianon) is the bactericide of BASF exploitation, and sterling is dark brown crystalline shape solid.Molecular formula C
14h
4n
2o
2s
2, chemical name is: 2,3-dinitrile-Isosorbide-5-Nitrae-anthraquinone dithio, and structural formula is:
Dithianon has multiaction mechanism, by react with sulfur-containing group and interference cell is breathed and suppressed a series of fungi mould, finally eliminates disease, while having good prolection, also has certain therapeutic activity.All kinds of diseases of garden stuff can be prevented and treated, as spot disease, scab, leaf spot, rust, anthracnose, downy mildew etc.
Difenoconazole (difenoconazole), trade name: scroe, diviend, other titles: demon's azoles, enemy committee is red, and generation is high.It is the triazole bactericidal agent of Syngenta Co., Ltd's exploitation.Sterling is that white is to rice white crystalline solid.Molecular formula: C
19h
17c
12n
3o
3
。Chemical name: suitable, and the chloro-4-of trans-3-[4-methyl-2-(1H-1,2,4-triazol-1-yl methyl)-1,3-bis-Evil pentane-2-base] phenyl 4-chlorphenyl ether (suitable, inverse proportion is about 45:55).Structural formula:
Difenoconazole is a kind of bactericide of broad-spectrum high efficacy; the biosynthesis of main suppression germ cell ergosterol; thus destroy membrane structure and function; be mainly used in fruit tree, vegetables, wheat, potato, beans, the crop such as melon, to the multiple fungal disease such as vegetables and melon and fruit, there is well protection and therapeutic action.To ascus subphylum; Basidiomycotina and the imperfect fungus comprising Alternaria, Ascochyta, the mould genus of tail spore, colletotrichum, ball seat Pseudomonas, Phoma, Ramularia, Septoria, raw meat Venturia; Erysiphaceae; Uredinales and some kind pass cause of disease mattress lasting protection and therapeutic activity; simultaneously to cercospora leaf spot of sugar beet; wheat glume blotch, leaf blight, rust and by several cause a disease microbial mildew; apple scab, powdery mildew; grape powdery mildew; target, leaf spot of peanut, net blotch etc. all have good result for the treatment of.
In recent years, along with a large amount of for a long time the coming into operation of unit dose preparation, disease drug resistance is on the rise, and brings very large difficulty to preventing and controlling.In order to address this problem, except enhancing field management, cultivating except new disease-resistant crop varieties, also new pesticide species to be developed.But the exploitation of novel pesticide is a process that cost is large, the cycle is long, is difficult to resolve the matter of great urgency of certainly current control of crop disease.Carrying out composite with dissimilar farm chemical ingredients, is the common method of of preventing germ drug resistance from producing.No matter different mechanism of action farm chemical ingredients composite, be insecticide or bactericide, have successful precedent.This method not only greatly reduces usage amount, the raising actual effect of agricultural chemicals, can also delay the drug-fast generation of germ.And not yet find up to now about Difenoconazole and the composite bactericidal composition of dithianon.
Summary of the invention
The object of the invention is to overcome existing issue, propose the disinfecting composition that a kind of high energy efficiency, low stain, low cost, fungicidal spectrum are wide, said composition is for primary activity composition with dithianon and Difenoconazole.
The present invention is achieved through the following technical solutions:
Containing the bactericidal composition of Difenoconazole and dithianon, it is characterized in that composition comprises following component when making water dispersible granules: dithianon 10-85%, Difenoconazole 1-45%, dispersant 3-10%, wetting agent 2-10%, disintegrant 1-5%, binding agent 1-5%, filler are supplied.
Described filler is one or more in kaolin, diatomite, bentonite, white carbon, starch.
Composition comprises following constituent content when making water dispersible granules: dithianon 10-85%, Difenoconazole 1-45%, dispersant 3-10%, wetting agent 2-10%, disintegrant 1-5%, viscosity-controlling agent 1-5%, filler are supplied.
Former medicine is obtained together with dispersant, wetting agent, disintegrant, filler etc. the particle diameter needed through air-flow crushing, then add other auxiliary agents such as viscosity-controlling agent, obtain granulation materials.Material dosing is sent in fluidized bed granulating dryer through granulating and after drying, obtaining dithianon and difenoconazole water dispersible granule product.
Described dispersant be selected from polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, glycerin fatty acid number APEO one or more.
Described wetting agent is natural products wetting agent and cationic wetting agent, available 120,000 basic sodium sulfonates, pull open in powder, lauryl sodium sulfate one or more.
Described disintegrant be selected from bentonite, ammonium sulfate, calcium chloride, urea, magnesium chloride, aluminium chloride, citric acid, carbonic hydroammonium one or more.
Described defoamer is selected from silicone oil, one or more in silicone compound, C10-C20 saturated fat acid compounds, C8-C10 aliphatic alcohols compound.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine.
Described viscosity-controlling agent is selected from: one or more in the compounds such as gum Arabic, xanthans, methylcellulose, polyethylene glycol.
Described bactericidal composition is particularly useful for alternaria leaf spot of apple, sigatoka, cucumber downy mildew, anthracnose etc.
The bactericidal composition containing Difenoconazole and dithianon that the present invention proposes, have for preventing and treating diseases of garden stuff the advantage that preventive effect is high, quick-acting good, the lasting period is long, and effectively can delay disease drug resistance generation, reduce cost, environmental pollution is little.
Embodiment:
Embodiment one: 60% dithianon+difenoconazole water dispersible granule
Batching: dithianon 30%, Difenoconazole 30%, lignin 3%, lauryl sodium sulfate 5%, urea 2%, starch 20%, kaolin surplus
Technique: by air-flow crushing machined, makes the fineness of material reach more than 600 orders, then carries out granulation by comminutor.Finally dry the water dispersible granules of system.
Quality index: wetting time≤60s disintegration time≤3min suspensibility >=90%
Embodiment two: 70% dithianons+difenoconazole water dispersible granule
Batching: dithianon 40%, Difenoconazole 30%, glycerine fatty acid APEO 3%, diatomite 5%, urea 2%, starch 20%, kaolin surplus
Technique: by air-flow crushing machined, makes the fineness of material reach more than 600 orders, then carries out granulation by comminutor.Finally dry the water dispersible granules of system.
Quality index: wetting time≤60s disintegration time≤3min suspensibility >=90%
Implementation of an application example one:
Difenoconazole and dithianon different ratio are to alternaria leaf spot of apple Toxicity Determination.
For examination bacterial classification: alternaria leaf spot of apple, rod method apple specialized form.
Each active constituent content of test medicine is designed 5 concentration for the treatment of respectively, take space management as contrast, indoor measurement is carried out to the inhibitory action of alternaria leaf spot of apple.Test adopts mycelial growth rate method, first each proportioning is become series concentration gradient.Be that the punching of edge place is for subsequent use in front of the blade for the aseptic card punch of 0.5CM by the alternaria leaf spot of apple germ diameter after cultivating through secondary separation, then move on pastille PDA plating medium, be placed in 25 ± 1 DEG C of incubators and cultivate, cultivate and measure colony diameter after 6 days.Often process repetition 6 times.Measured result calculates antibacterial percentage compared with the control.5 proportionings are carried out synergism test.Computing formula is as follows:
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probability value (y), and liquor strength (μ g/ml) converts logarithm value to (x), tries to achieve virulence regression equation (y=a+bx), and calculate the EC of often kind of medicament thus with method of least squares
50value.Calculate two kinds of medicament different ratio synergies ratio (SR) according to Wadley method, SR < 0.5 is antagonism, and 0.5≤SR≤1.5 are summation action simultaneously, and SR > 1.5 is synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively dithianon and Difenoconazole ratio shared in the composition:
A is dithianon, B is Difenoconazole
The virulence regression equation of the dithianon obtained, Difenoconazole and composite comparison alternaria leaf spot of apple, suppress in concentration and synergy ratio (SR) as following table:
As shown in Table 1, Difenoconazole of the present invention and dithianon composite to alternaria leaf spot of apple Toxicity Determination, the virulence of Difenoconazole is higher than the virulence of dithianon, the synergy ratio being 1:1,4:1,7:1,10:1,13:1 when dithianon and Difenoconazole proportioning is respectively 1.21,1.53,1.76,1.68,1.44, wherein when dithianon: show as synergistic effect when Difenoconazole is 4:1,7:1,10:1, with dithianon: during Difenoconazole=7:1, synergistic effect is the most obvious.
Implementation of an application example two: Difenoconazole and dithianon is composite prevents and treats the sigatoka test of pesticide effectiveness
This experimental establishment is in suburb, Heze city of Shandong province, and experimental pharmacy has Shandong Qilin Agriculture Chemicals Co., Ltd. to research and develop to be provided, contrast medicament 75% dithianon water-dispersion granule (commercial), 10% difenoconazole water dispersible granule (commercial).
Before dispenser, investigation calculates disease index, and dispenser in every 7 days once, is total to dispenser 3 times.7 days, 14 days, 30 days investigation disease indexs after dispenser also calculate preventive effect, and result of the test is as following table.
Table 2 Difenoconazole and dithianon is composite prevents and treats the sigatoka test of pesticide effectiveness
As can be seen from Table 2, the present composition has good effect to sigatoka, and after dispenser, preventive effect reaches more than 90%, effectively can control the generation of sigatoka, and preventive effect is better than contrasting medicament, and quick-acting, lasting effect are all better than contrasting medicament.In test scope of medication, Target crops is had no adverse effects, and have good preventive effect to banana freckle.
In sum, Difenoconazole and dithianon composite after, for preventing and treating the disease on fruits and vegetables, Be very effective, with contrast medicament compared with, there is the advantage that quick-acting is good, the lasting period is long, dosage is little, cost is low.In trial stretch, to crop safety, have no adverse effects.So research and extension tool of the present invention is of great significance.
Claims (3)
1. the microbicide compositions containing Difenoconazole and dithianon, is characterized in that: composition contains Difenoconazole 1-45% and dithianon 10-85%, more in addition water dispersible granules made by auxiliary agent filler.
2. the bactericidal composition containing Difenoconazole and dithianon according to claim 1, is characterized in that composition comprises following component when making water dispersible granules: Difenoconazole 1-45%, dithianon 10-85%, dispersant 3-10%, wetting agent 2-10%, disintegrant 1-5%, binding agent 1-5%, filler are supplied.
3. the bactericidal composition containing Difenoconazole and dithianon according to claim 1 is applied on vegetables and fruit tree.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410279248.6A CN105191945A (en) | 2014-06-21 | 2014-06-21 | Bactericidal composition containing difenoconazole and dithianon |
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|---|---|---|---|
| CN201410279248.6A CN105191945A (en) | 2014-06-21 | 2014-06-21 | Bactericidal composition containing difenoconazole and dithianon |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006666A2 (en) * | 2002-07-10 | 2004-01-22 | Basf Aktiengesellschaft | Fungicidal mixtures based on dithianon |
| CN101584320A (en) * | 2009-04-01 | 2009-11-25 | 陕西蒲城县美邦农药有限责任公司 | Dithianon and difenoconazole-containing antiseptic composition |
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2014
- 2014-06-21 CN CN201410279248.6A patent/CN105191945A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006666A2 (en) * | 2002-07-10 | 2004-01-22 | Basf Aktiengesellschaft | Fungicidal mixtures based on dithianon |
| CN101584320A (en) * | 2009-04-01 | 2009-11-25 | 陕西蒲城县美邦农药有限责任公司 | Dithianon and difenoconazole-containing antiseptic composition |
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Application publication date: 20151230 |