CN105169000A - Drug for preventing and treating winter dysentery of pigs and production method thereof - Google Patents

Abstract

The invention discloses a drug for preventing and treating winter dysentery of pigs. The drug is prepared from the following raw materials in parts by weight by a conventional technology: 20 to 40 parts of root of Chinese pulsatilla, 8 to 10 parts of guava leaf, 8 to 10 parts of sticktight, 6 to 8 parts of bamboo leaf, 60 to 80 parts of charcoal ash, 15 to 17 parts of palm bark, and 20 to 40 parts of plant soot. The plant soot is prepared by burning Chinese fir, pine, or chestnut tree. The drug is prepared by subjecting traditional Chinese herbals to alcohol extraction, refluxing, decocting, extraction, and condensation. The drug is developed on the basis of traditional/modern traditional Chinese medicine theories, knowing of pathogenesis of winter dysentery of sows and suckling pigs, and therapeutic principle of traditional Chinese medicine, can effectively treat winter dysentery of sows and suckling pigs, has little side or toxic effect, does not generate drug resistance, can guarantee healthy growth of pigs, and promotes the stable and positive development of artificial pig breeding.

Description

The medicine of control pig winter dysentery and production method thereof

Technical field

The present invention relates to the field of control pig disease, particularly relate to a kind of medicine and production method thereof of preventing and treating pig winter dysentery.

Background technology

Swine dysentery ( swinedysentery) be a kind of serious infectious intestinal disease being caused pig by pathogenic swine dysentery Serpulina, also known as dysentery.Main clinical symptom is serious mucus and mucus hemorrhagic dysentery, and acute is based on hemorrhagic dysentery, subacute and chronic based on mucus diarrhoea.Cuing open inspection pathological characters is colorectal mucosa generation Catarrhal, hemorrhagic and gangrenous inflammation.Primary disease in the world many pig-raising countries and area has the report of generation, and the boar Late Cambrian primary disease of China in October, 1978 by imported from America, Shanghai City animal and veterinary institute is diagnosed as swine dysentery through campaign.Thereafter expand in Chinese epidemic situation, spread, now there is primary disease in existing more than 20 province, city, be that ubiquitous common transmittable is one of sick, because pig is dead, rate of growth reduces, price of deed rate is low, medicine and the increase of epidemic prevention expense etc., caused very large economic loss to pig industry.

Swine dysentery Serpulina (Serpulinahyodysenteriae), be also called Brachyspira hyodysenteriae (Brachyspirahyodysenteriae), belong to Serpulina and belong to (Serpulina) member, be present in the feces of the pathological changes intestinal segment mucosa of disease pig, intestinal contents and discharge.

Swine dysentery Serpulina, Gram-negative, aniline dyes or Ji's nurse Sa dyeing liquor well painted, tissue slice with silver staining as well, visible two ends are sharp-pointed, shape is as two wild goose wing, long 6 ~ 8 μm of thalline, wide 0.32 ~ 0.38 μm, 4 ~ 6 are had to bend, fresh pathological material of disease is under darkfield microscope, visible rotary motion centered by major axis vivaciously, 7 ~ 9 axial filaments are had under an electron microscope between visible cell wall and adventitia, axial filament is overlapping near middle part of cell, there is mobility and hemolytic, under darkfield microscope, visible its active Serpentis sample motion.

This bacterium is strict anaerobe, requires comparatively strict, generally do not cultivate condition of culture.During as cultivated, conventional casein trypsinization Semen sojae atricolor blood agar or casein Tryptic Soy soup, serum-free medium containing bovine serum albumin and cholesterol, in the anaerobic jar that an atmospheric pressure 80%H2 (or anaerobic N2), 20%C02 take palladium as catalyst, cultivate 6 days for 37 ~ 42 DEG C, on blood agar, visible significantly β haemolysis.At the edge of haemolysis band, there are cloud thin layer growth-gen or the transparent bacterium colony of tip-like.Serpulina can only decompose a few sugar, as glucose, fructose, lactose, produces indole, does not produce hydrogen sulfide, not liquefy gelatin, catalase, cytochrome oxidase negative.

Swine dysentery Serpulina does not rely on other microorganisms to colon, the pathogenic of caecum, but the essential condition that the intrinsic anaerobe of enteral is then this bacterium settles down and cause pathological changes serious.So, when infecting aseptic pig with this fungus oral, there is not symptom and pathological changes.Swine dysentery Serpulina contains two kinds of antigenic components, and one is proteantigen, multiple specific antigen, can with the antibody generation precipitation of swine dysentery Serpulina, and not react with other animal Serpulina antibody; Another kind is boivin antigen, is type specific antigen, and this bacterium is divided into 4 serotypes by available agar gel diffusion test.

Swine dysentery Serpulina to external world environmental resistance is comparatively strong, can survive 30 days, can survive 102 days in soil when 4 DEG C, survive 61 days in feces when 5 DEG C, survive 7 days when 25 DEG C in airtight pig house fecaluria ditch, very fast dead when 37 DEG C.Sunlight is irradiated, heats and drying sensitivity.Disinfectant conventional in veterinary practice and typical concentrations, as peracetic acid, sodium hydroxide, saponated cresol etc. can be killed rapidly.

Sick pig and the pig that carries disease germs are the main sources of infection, rehabilitation pig bacterial bearing rate is high, carriagable time is the several months, often along with feces discharges a large amount of pathogenic bacteria, pollute feedstuff, drinking-water, pigsty, feed trough, apparatus, surrounding, means of transport and sow body (comprising nipple), through digestive tract infection, the feedstuff that health pig wedging pollutes, drinking-water infect, by digestive tract infection after piglet birth, morbidity before and after wean.In natural situation, pig is only caused to fall ill.The pig of different cultivars, all ages and classes all can infect, and occurs at most with 2 ~ 3 monthly age children pigs.The sickness rate of piglets and case fatality rate higher than large pig.General sickness rate 70% ~ 80%, case fatality rate 30% ~ 60%.

Primary disease all can occur throughout the year, and the popular initial stage, case fatality rate was high in the most acute and acute, many in subacute and chronic thereafter, affects the growth promoter of pig.Feeding and management is bad, be deficient in vitamin and mineral, transport, cold, the stressors such as overheated, can promote that primary disease occurs and increases the weight of the state of an illness.The primary disease epidemiological process time is long, and swinery can fall ill repeatedly, on larger pig farm, and Chang Keda some months.

Primary disease is many causes morbidity because introducing the boar carried disease germs, and China has many examples disseminating morbidity with the flowing of boar.What have also causes indirectly by communication media.According to reporting in recent years, after dog, cowbird peroral infection, dog 13 days, cowbird can discharge thalline in 8 days from feces.It is more than 100 day that mice carries disease germs, and rat carries disease germs 2 days, and fly at least carries disease germs 8h.Be separated to Serpulina from the mouse pig house, domesticated dog, fly, the media transmission effect of these animals is very important.

Pig winter dysentery is the disease generally occurred cold season, is the general designation of epidemic diarrhea, transmissible gastroenteritis, acute viral bacterial infectious disease.Pig winter dysentery occurs in China year after year, and continue many decades, and its sickness rate is high, quantity is many.The principal character of winter dysentery is violent watery diarrhea, continues 5 ~ 7 days, can reach l0 every day remaining time, loss of appetite or absolutely useless, rapid dehydration, becomes thin, and even exhaustion is dead, and pig sickness rate changed because of year and area, mostly was 50% ~ 90%.

There is vomiting after being everlasting and sucking the breast in ill suckling pig, occurs violent diarrhoea soon, and feces be water sample yellow or canescence, with indigested little ziega, and stench; Sick pig spirit is depressed, loss of appetite, and body temperature raises a little or normally, pig body dewaters very soon, becomes thin rapidly, and pig age in days is less, and mortality rate is higher.Large pig classical symptom is vomiting, and water sample, yellow diarrhoea, search for food and stop 1-2 days.After pig morbidity, there will be serious diarrhoea, part piglets will be dead; Although large pig can not be dead, between period of disease (general about 7 days), pig weight loss, causes certain loss to raiser.

For the prevention of pig winter dysentery, one is strengthen winter management, notices that pig house is warming, and the supply of energy and feedstuff, strengthens the resistance of pig.Particularly the birth piglet of latter 1-2 days, more should notice that pig house is incubated, and keeps pig house temperature at about 32 DEG C; After birth, allow piglet be able to eat colostrum as early as possible, human assistance hello breast will be strengthened to weak piglet and close.Two is the disinfections of doing pig house well.In daily pig house management, piggery feces to be cleared up in time, keep pig house clean dry; 1 time (lime cream should being cleaned out after having sterilized) is sterilized every 15d lime cream; In addition, also should strengthen pig to search for food the clean of utensil and sterilization; Strengthen the management of disease pig and isolate in time.Three is adopt vaccinate to carry out prevention and corntrol, but vaccine can not control whole piglet diarrhea, once morbidity also should take certain remedy measures.Because this sick pathogeny is more special, use single vaccine pig winter dysentery may not prevented completely.Although at present in this disease of development polyvalent vaccine therapeutic alliance.But due to the pathogeny that it is special, research difficulty is very large.

Summary of the invention

In order to solve above-mentioned Problems existing, the invention provides a kind of medicine and production method thereof of preventing and treating pig winter dysentery.The present invention have toxic and side effects little, do not produce drug resistance, there is the feature of obvious therapeutical effect.

The present invention realizes by the following technical solutions:

Prevent and treat a medicine for pig winter dysentery, it be by the raw material of following parts by weight routinely preparation process produce: Radix Pulsatillae 20-40, Folium Psidii Guajavae 8-10, Herba Bidentis Bipinnatae 8-10, Folium Bambusae 6-8, ash wood 60-80, Fibra Trachycarpi 15-17, the bottom of a pan ash 20-40; Described ash wood is the ash wood burnt till with Lignum seu Ramulus Cunninghamiae Lanceolatae, Masson Pine or chestnut.

Preferably, the parts by weight of each raw material are: the Radix Pulsatillae 20, Folium Psidii Guajavae 8, Herba Bidentis Bipinnatae 8, Folium Bambusae 6, ash wood 60, Fibra Trachycarpi 15, the bottom of a pan ash 20.

Preferably, the parts by weight of each raw material are: the Radix Pulsatillae 30, Folium Psidii Guajavae 9, Herba Bidentis Bipinnatae 9, Folium Bambusae 7, ash wood 70, Fibra Trachycarpi 16, the bottom of a pan ash 30.

Preferably, it is characterized in that, the parts by weight of each raw material are: the Radix Pulsatillae 40, Folium Psidii Guajavae 10, Herba Bidentis Bipinnatae 10, Folium Bambusae 8, ash wood 80, Fibra Trachycarpi 17, the bottom of a pan ash 40.

The production method of control pig winter dysentery medicine, contains following steps:

A. get clean Fibra Trachycarpi, put in pot, cover the pot that a bore is slightly little, a piece of paper pasted by pot, sternly seal in two pots of joint yellow mud, it is that coke yellow is ceased fire that low baking temperature is calcined to blank sheet of paper, and Hou Leng takes out, and grinds to form Petiolus Trachycarpi powdered carbon;

B. get the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae by formula, first use alcohol reflux, obtain extracting solution A, residue medicinal residues decoct with water extraction again, collect extracting solution and are designated as extracting solution B, mix rear and be condensed into clear paste by extracting solution A and extracting solution B;

C. step b gained medicinal residues are dry, then pulverize, add the Petiolus Trachycarpi powdered carbon of ash wood, the bottom of a pan ash and step a gained, mix homogeneously, obtains mixture C;

D. by step c gained mixture C and the mixing of step b gained clear paste, then add adjuvant and conventionally make granule.

The medicine of control pig winter dysentery, its using method is: wash water open in the ratio of every pig 100 grams and gavage, or spice is fed, every day 3 times, and connect and feed 2 ~ 3 days, preventive dose reduces by half.

In the raw material of Chinese medicine that the present invention chooses, each medicine active ingredient is analyzed:

The Radix Pulsatillae (Classification system: pulsatillachinensis(Bunge) Regel), Ranunculaceae, Anemone herbaceos perennial, another name has how grass, powder silkweed, Bai Toucao, old aunt grass etc.Plant height 15-35 centimetre.The thick 0.8-1.5 centimetre of root stock.Basal leaf 4-5, just bears when blooming usually, has long handle; Blade width egg shape, long 4.5-14 centimetre, wide 6.5-16 centimetre, three totally cleave, in the sheet that totally cleaves have handle or nearly stockless, width egg shape, three drastic cracks, middle drastic crack sheet wedge-like obovate, rare narrow wedge shape or inverted trapezoidal, full edge or have tooth, side drastic crack sheet does not wait two shallowly to split, and totally cleave sheet stockless or nearly stockless in side, do not wait three drastic cracks, surface becomes without hair, and there is long pubescence at the back side; The long 7-15 centimetre of petiole, has close long pubescence.Scape 1(-2), there is pubescence; Bract 3, the cylinder of base portion symphysis growth 3-10 millimeter, three drastic cracks, drastic crack sheet is linear, does not divide or top three is shallow splits, the close villosity in the back side; The long 2.5-5.5 centimetre of bennet, reaches 23 centimetres during result; Spend upright; Sepal bluish violet, oval shape is avette, long 2.8-4.4 centimetre, wide 0.9-2 centimetre, and there is close pubescence at the back side; Stamen is about as sepal half.Aggregate fruit diameter 9-12 centimetre; Achene spindle, flat, long 3.5-4 millimeter, has long pubescence, and the long 3.5-6.5 centimetre of style is deposited in place, has the long pubescence of upward exhibition.April bloomed to May.At distribution in China in Sichuan (Baoxing, At 3200 m Above Sea-level), the north, Hubei, Jiangsu, Anhui, Henan, SOUTH OF GANSU, Shaanxi, Shanxi, Shandong, Hebei (height above sea level 200-1900 rice), the Inner Mongol, Liaoning, Jilin, Heilungkiang.In former and hillside, the low mountain thick grass of life, the hillside fields of Lin Bian or dry early many stone.Also distribution is had in Korea and the Far East Area of the Soviet Union.Nature and flavor: bitter, cold.1. " herbal classic ": " bitter in the mouth, temperature, nontoxic." 2. " not Lu ": " be poisonous." 3. " property of medicine opinion ": " sweet-bitter flavor, slightly poisonous." 4. Li Gao: " bitter in the mouth, cold in nature." return through: enter large intestine, liver, stomach warp.1. " Thunder God concocts property of medicine solution ": " enter the heart, kidney two warp." 2. " Bencao Jingshu ": " starts with, Foot yangming Channel blood system." 3. " Changsha medicine solution ": " enters foot-shaoyang gallbladder, liver channel of foot-Jueyin." function cures mainly: clearing away heat and cooling blood, removing toxic substances.Control toxic-heat and blood stasis, pyrexial malaria cold and heat, epistaxis, internal hemorrhoid with bleeding.1. " herbal classic ": " the mad easy cold and heat of main pyrexial malaria, lump in the abdomen, goiter, by blood and relieving pain, incised wound." 2. " not Lu ": " (master) epistaxis." 3. TAO Hong-Jing: " treats fulminant dysentery." 4. " property of medicine opinion ": " be stomachache and red fulminant dysentery only, controls toothache, tumor scrofula under major event." " main hundred pain all over the joints." 5. " Japan hanako materia medica ": " controls all pathogenic wind and warm waist knee joint, and improving eyesight, disappears superfluous.Son: function is the same." 6. " typhoid fever accumulate want ": " pyretic toxicity dysentery purple blood blood person should it." 7. " book on Chinese herbal medicine converges and says ": " removing heat from blood, repercussive, separates noxious dampness." 8. essentials of Matea Medica: " controls tinea alba, scrofula, hernia abdominal mass, internal hemorrhoid with bleeding, the swelling and hanging down of either of the testes, improving eyesight, and disappear wart." 9. " detailed outline is picked up any lost article from the road ": " removes intestinal dirt, and removing food stagnancy is stagnant." 10. " modern Practical Chinese medicinal ": " treats pharyngeal swelling."

Folium Psidii Guajavae (Latin plant animal mineral name: psidiumguajavaL.), another name: chicken vows tea, kind Folium Persicae, bar in fiber crops, Gui Xiangla, that pulls out leaf, that pulls out the heart, pulls out the young heart, the Fructus psidii guajavae immaturus heart.Guava is deciduous tree, high 5 ~ 10m.Bark fawn, master pulse swells, and lateral vein 7 ~ 11 is right, also swells, and nearly tiltedly goes out leaf margin and bends; Cry handle long 4mm.Flower both sexes, raw 1 ~ 4 of axil; Calyx 5, green, oval; Petal white, avette, long 2 ~ 2.5cm; Stamen is most, isometric with petal, filigree white, and flower pesticide is light yellow, lobe; Gynoecium 1, style is longer than filigree, and stigma is circular, and ovary is the next, Room 3, and ovule is most.Berry is spherical, oval or bartlett pear shape, and long 2.5 ~ 8cm, footpath 3 ~ 5cm, sarcocarp is usually yellow, also adularescent or kermes.Seed oval, pale.5 ~ August of florescence.Really 8 ~ November of phase.Folium Psidii Guajavae is that square round shape is oval to oval, many shrinkages Zheng Qu or fragmentation, long 5 ~ 12cm, wide 3 ~ 5cm, tip circle opens short point, and base portion print is extremely circular, the full edge in edge, the light brown brown of upper surface, without hair, lower surface taupe brown, close by pubescence, master pulse and lateral vein all swell, and lateral vein is linked to be limit arteries and veins at nearly leaf margin place.Long 3 ~ the 6mm of petiole.Keratin and crisp, frangibility.Flat four prismatics of tender stem, must by pubescence.Gas delicate fragrance, puckery, micro-sweetness and bitterness.Spring, summer gather, and dry or using fresh herb.Function cures mainly: drying damp and strengthening spleen; Heat-clearing and toxic substances removing.Main dysentery stomachache; Dyspeptic abdominal distention; Gingivitis; Rheumatic arthralgia; Eczema ecthyma; Furuncle swelling toxin; Treating swelling and pain by traumatic injury; Traumatic hemorrhage; Snake bite and insect sting." Nanning City's medicine will ": astringing to arrest diarrhea.Control and have loose bowels, chronic dysentery, eczema, wound hemorrhage.

Herba Bidentis Bipinnatae (Classification system: BidenspilosaL.) one, first appeared in supplement to the Herbal, is Compositae annual herb plant.Different name there's something fishy hairpin grass (supplement to the Herbal), SANYE Bidens bipinnata, bidens pilosa, terrible Hemerocallis citrina Baroni, Shandong lao-ya-tsao, Herba Bidentis Bipinnatae, terrible spicule, fork woman, terrible Fructus Tribuli, sticky body grass, steel fork pin, terrible muscle are careless.Annual herb, stem is upright, high 30-100 centimetre, blunt four prismatics, and without hair or top by extremely sparse pubescence, base diameter can reach 6 millimeters.The lower portion of the stem leaf is less, 3 split or do not divide, usually wither before flowering, the long 1.5-5 of middle leaf tool centimetre aptery handle, three go out, 3 pieces, lobule, it is seldom the winglike compound leaf of tool 5-7 lobule, both sides lobule is oval or ovum shape is oval, long 2-4.5 centimetre, wide 1.5-2.5 centimetre, the sharp point of tip, base portion subcircular or wealthy wedge shape, sometimes deflection, asymmetric, tool short handle, there is sawtooth at edge, terminal leaflet is larger, oblong or ovum shape Long Circle, long 3.5-7 centimetre, tip is gradually sharp, base portion is narrow or subcircular gradually, the handle of the long 1-2 of tool centimetre, there is sawtooth at edge, without hair or by extremely sparse pubescence, upper leaf is little, 3 split or do not divide, strip lanceolar.Flower head diameter 8-9 millimeter, has long 1-6(fruit duration 3-10) centimetre peduncle.Involucre base portion by pubescence, bract 7-8 piece, strip cochlear, top is slightly wide, duration 3-4 millimeter of blooming, and fruit grows to 5 millimeters, herbaceous stem, edge is dredged by pubescence or several without hair, outer supporting spring lanceolar, the long 5-6 millimeter of fruit, dry film matter, back side brown, the yellow edge of tool, internal layer is narrower, strip lanceolar.Without ligulate flower, disc floret tubular, is about 4.5 millimeters, limb 5 fissure.Achene black, bar shaped, slightly flat, tool rib, long 7-13 millimeter, wide about 1 millimeter, the sparse strumae of top tool and bristle, top prickle 3-4 piece, long 1.5-2.5 millimeter, tool glochid.Herba Bidentis Bipinnatae is distributed in the subtropical and tropical zones in Asia and America, and the East China of China, Central China, south China, southwestern each provinces and regions, be grown on the wasteland, roadside of height above sea level 50-3100 rice, hillside and field, for folks of china commonly uses medical herbs unisexuality gymnosperm.Florescence 8 ~ JIUYUE.Really 9 ~ November of phase.Have effect of heat-clearing and toxic substances removing, removing blood stasis and activating blood flow, cure mainly upper respiratory tract infection, laryngopharynx swelling and pain, acute appendicitis, acute icterohepatitis, gastroenteritis, Fengshi Guanjie pain, malaria, furuncle, venom, treating swelling and pain by traumatic injury are controlled in external.

Folium Bambusae ( phyllostachysnigra (Lodd.) Munrovar.henonis (Mitf.) StapfexRendle) be the leaf of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle (bamboo).Effect of Folium Bambusae: clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid.Control calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea tells nosebleed, flushed complexion, oliguria also, erosion of the oral mucosa tongue boil.1. " not Lu ": the main heat of expectorant in the heart, cough with dyspnea.2. " property of medicine opinion ": main haematemesis pyretic toxicity wind, only quench one's thirst.3. " Treatise on Dietetic Therapy ": main cough with dyspnea, quench one's thirst, phlegm retention, sore throat, heat clearing away and restlessness relieving.4. " Japan hanako materia medica ": expectorant, control fanatical unhappiness, apoplectic aphasia in silence, high fever, headache wind syndrome of head, and cherish the pregnant number of people and revolve and fall down to the ground, throb with fear, and pestilence fan is vexed, and pediatric epilepsy scared sky hangs by spasmolytic.5. Zhang Yuansu: cool heart channel, beneficial vigour, heat extraction, slow spleen.6. " detailed outline ": decoct extract, gargle in tooth hemorrhage, eluting anus is not received.7. " book on Chinese herbal medicine is just ": the irritated sleeplessness of reducing the asthenic fever, only excessive thirst, born fluid, Li little Shui, separates sore throat, and children's wind-heat infantile convulsion.8. " Chongqing hall random notes ": the wind of interior breath liver and gall, the heat of outer clear temperature administration, therefore have the merit of relieving convulsion of calming the nerves.9. " book on Chinese herbal medicine is new again ": cool heart spleen invigorating, haematemesis, nose bleeding is controlled, hearing-improing and eyesight improving.

Linesless charcoal (charcoal) be timber or wood material through imperfect combustion, or pyrolysis under the condition of isolated air, the dark brown that remains or black porosu solid fuel.Linesless charcoal main component is carbon, and ash is very low, calorific value about 27.21 ~ 33.49 million Jiao/kilogram, also have hydrogen, oxygen, nitrogen and other a small amount of elements in addition, the relation of its content and seeds is little, depends primarily on the final temperature of carbonization.Linesless charcoal belongs to hydrophobic substance, and content of ashes is within 6%, and hole accounts for Linesless charcoal volume more than 7%, and proportion is generally 1.3 ~ 1.4, and caloric value depends on carbonization condition, and generally about 8000 kcal/kg, the reducing power of Linesless charcoal is greater than coke.Linesless charcoal has a large amount of micropores and transitional pore, makes it not only have higher specific surface area, and in hole, tar material will have good absorption property after being excluded.To burn completely generation carbon dioxide with oxygen, imperfect combustion produces toxic gas carbon monoxide.Comparatively loose.Can be divided into by the raw material of making charcoal: 1. hard wealthy Linesless charcoal.By hard broadleaf if Fagaceae Quercus acutissima genus, Castanopsis trees are main, secondary also has Betula etc.As beech, birch, Quercus acutissima, bitter sweet oak, elm, maple etc.2. broad-leaved Linesless charcoal.By charcoal that is hard, Deciduous trees mixed sintering.As poplar, Hibiscus syriacus, willow etc.3. Masson Pine charcoal.The charcoal fired by Masson Pine or other softwoods.As Pinus massoniana Lamb, Pinus koraiensis, PiceameyeriRehd. Et Wils. etc.Linesless charcoal can control following all diseases: 1) gulp down gold, silver by mistake, copper, ferrum enters abdomen.Burn red with charcoal, beat into smalls while hot, decoct soup and drink.As invalid, just scraping charcoal end three money, well water is taken after mixing with liquid, and invalidly eats again, eventually can the thing discharge gulped down by mistake.2) pharynx is obstructed suddenly.With Linesless charcoal end with closely make a ball, gradation contains and drinks.3) white tiger syndrome caused by wind pathogen (joint as bitten into pieces by what, the place of pain, migration is indefinite).Twist with the fingers (one twists with the fingers, and is that two fingers pinch) with charcoal ash five liters, Lumbricus dung one liter, Flos Carthami seven, endure altogether, after enduring, mixed with vinegar, wrap with old cloth, press sore spot while hot.4) discharging fresh blood stool.With tight charcoal three money, Fructus Aurantii ashing five money, be ground into end, often take three money, take time just before dawn, rice water send down, and daybreak takes once again, and the same day takes effect.Diet is greasy.5) soup fire is burnt.Adjust with charcoal end and Oleum sesami and be coated with.6) tuberculoid leprosy head sore.Burn red with Linesless charcoal, drop in boiled water, temperature is washed effectively.7) scrotum pruritus due to damp pathogen.With bran charcoal and Folium Perillae, grind into powder and wipe affected part.Ash wood is exactly the ash that Linesless charcoal burns till, and is Linesless charcoal at logical oxygen or the white stayed after all burnt in atmosphere or linen material; Its main component is potassium carbonate, the aobvious alkalescence of aqueous solution of potassium carbonate.Linesless charcoal has the function of absorption foul smell, fills out pad stock barn animal house with it, can deodorization, improves poultry living environment, promotes growth of animals or poultry.Linesless charcoal also has the effect strengthening poultry digestion power, adds a small amount of charcoal powder, can accelerate animal growth and development in feedstuff, improves the quality of meat and milk.As female animal just before giving birth the last week, in daily ration, add the charcoal powder of feeding 2% every day, not only grow up useful to fetus later stage skeleton development, can also prevent puerperal self that paralysed disease occurs.

Petiolus Trachycarpi (formal name used at school: trachycarpusfortunei (Hook.) H.Wendl.) belonging to Palmae aiphyllium, Gao Keda 15 meters, trunk diameter reaches 24cm, rare branch.Leafage is erected in top, subcircular, footpath 50 ~ 70cm, and palmate is split and deeply reached middle and lower part; Long 40 ~ the 100cm of petiole, both sides serration is obvious.Dioecism, coniform spadix axil is raw, spends little and yellow.The drupe kidney shape is spherical, and footpath is about 1cm, and blue brown, by white lead.In 4 ~ May of florescence, 10 ~ November, fruit was ripe.Fibra Trachycarpi is the sheath fiber of babassu Petiolus Trachycarpi.The whole year can adopt, and generally more than its fibrous sheath sheet peeled of gathering between 9 ~ October, removes residual skin, dries.Character: the Chen Jiuzhe of Fibra Trachycarpi, name " old brown skin ".Useful petiole part or useless coir rope in commodity.Fiber outside being pruned by petiole, dries, " brown bone " by name; Shabby brown bed taken from by useless coir rope more, " old palm fibre " by name.1. old brown skin, be slightly long fiber, fasciculation or lamellar, differ in size by long 20 ~ 40 centimetres.Color is brown, and matter is tough, not easily tear fracture.Gas without, lightly seasoned.Being good without rough bark, impurity and Chen Jiuzhe.2. brown bone, has another name called: Petiolus Trachycarpi.Elongated, different in size, rufous, base portion is wider and flat, or slightly curves inwardly, upwards then gradually narrow and thick, back side central uplift, triangularity, both sides, the back side are smooth, on have thick close rufous young pilose antler, the outside of belly is smooth, or slightly concaves, and has the texture of cross.After tearing epidermis off, fiber tough and tensile as seen.Matter is tough and tensile, can not fracture.Gas without, lightly seasoned.With rufous, sheet is large, matter is thick, Chen Jiuzhe is good.3. old palm fibre is the netted of fragmentation.Color depth palm fibre, coarse.Matter is tough and tensile, not easily broken.Feeble QI, lightly seasoned.Be good with atrous, free from admixture person.Petiolus Trachycarpi originates in the ground such as Jiangxi, Jiangsu, Anhui, Zhejiang, Fujian, Taiwan, Guangdong, Guangxi, Hunan, Hubei, Sichuan, Guizhou, Yunnan.South China, the multiplex old brown skin in southwest; The multiplex brown bone in the area such as North China, northeast, northwest; East China is multiplex old palm fibre then.The chemical analysis of Fibra Trachycarpi: palm fiber and leaf, spend and be all rich in tannin.The nature and flavor of Fibra Trachycarpi: pained are flat.1. supplement to the Herbal: " bitter and puckery flavor is flat, nontoxic." 2. " Haiyao Bencao, Oversea Materia Medica ": " flat temperature." return through: " key medicine divides agent ": " enters liver, spleen two warp." function of Fibra Trachycarpi cures mainly: hemostasis with astringents.Control haematemesis, epistaxis, have blood in stool, stranguria with blood, hematuria, dysentery, metrorrhagia, leukorrhagia, incised wound, scabies.1. " this leather is picked up any lost article from the road ": " burn and make ash, main removing blood stasis hemostasis." 2. " Haiyao Bencao, Oversea Materia Medica ": " main incised wound scabies, promoting regeneration of the tissue and arresting bleeding, and should use by ashing." 3. " Japan hanako materia medica ": " be serious epistaxis, haematemesis only, and broken disease, controls metrorrhagia, leukorrhagia, hemorrhoidal hamorrhage, dysentery with red and white feces.To be used as medicine ashing use, can not exhausted mistake." 4. amplification on Canon of Materia Medica: " burns for grey black, only married woman's blood dew and spitting blood, his medicine of still helping."

The bottom of a pan ash, Chinese medicine formal name used at school: Pulvis Fumi Carbonisatus, Latin plant animal mineral name: fuligoPlantae, English name: plantSoot, Sootfromthebottomofaboiler, another name: below the moon black at the bottom of dirt, tobacco ash, Fu Yue China and Mexico, pan ink, stove volume inking, still in ink, chimney under ash, black, the still of chimney, the bottom of a pan is black, pan ground coal, stove volume ink, still coal, still Tai, the bottom of a pan ash, stove bituminous coal, stove coal, the soot on the bottom of a pan, the bottom of a pan coal.For investing the black flue dust in the bottom of a pan or chimney after Caulis et Folium Oryzae, wheat straw, weeds burning.Scraping in the bottom of a pan or chimney of burning faggot, sieves decontamination with dusting cover, puts in bottle and use.Character: Powdered, or be bonded to fine granularity, i.e. the powdered of hands sth. made by twisting.Black.Body is light, and matter is thin like frost, enters water then floating and disperse.That touches touches with one's hand, without greasy feeling.Feeble QI, lightly seasoned micro-pungent.With darkish complexion, body is light, matter is thin, free from admixture person is good.Chemical analysis: main containing carbon granules.Nature and flavor: bitter; Pungent; Warm in nature.Gui Jing: liver; Lung; Stomach warp.Function cures mainly: hemostasis; Removing food stagnancy; Sterilizing powdered medicine fire.Main haematemesis; Epistaxis; Have blood in stool; Metrorrhagia; Leukorrhagia; Food stagnation; Dysentery; Jaundice; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Ecthyma; White bareheaded skin ulcer; Traumatic hemorrhage.

Outstanding substantive distinguishing features of the present invention and significant progress are:

1, the present invention's medicine of preventing and treating pig winter dysentery by theory of Chinese medical science by the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae, ash wood, Fibra Trachycarpi, the bottom of a pan ash routinely explained hereafter form, reference is Chinese medicine pharmacological research achievement at all times, based on Chinese medicine to pathogenetic understanding of pig winter dysentery and Therapeutic Principle, can effectively treat pig winter dysentery, ensure growing up healthy and sound of pig, promoted that the industry of manually raising pigs is stablized, positive development;

2, the medicine that the present invention prevents and treats pig winter dysentery has natural, safe, nontoxic, efficient, to improve immunity of organisms advantage compared to existing technology, can adjust the imbalance state of body, reach effect for the treatment of both the principal and secondary aspects of a disease;

3, the present invention prevents and treats the medicine of pig winter dysentery, and be applied to the treatment of pig winter dysentery, it adopts Chinese herbal medicine formula, and noresidue medicine after curing, has ensured safety and the animal health of medicine;

4, the present invention prevents and treats the medicine of pig winter dysentery, and expense is cheaper, instant effect, and curative effect is short, and cure rate is high.

Detailed description of the invention

Embodiment 1

Prevent and treat a medicine for pig winter dysentery, it be by the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae, ash wood, Fibra Trachycarpi, the bottom of a pan ash routinely explained hereafter form; Described ash wood is the ash wood burnt till with Lignum seu Ramulus Cunninghamiae Lanceolatae, Masson Pine or chestnut.

The production method of control pig winter dysentery medicine, contains following steps:

A. get clean Fibra Trachycarpi, put in pot, cover the pot that a bore is slightly little, a piece of paper pasted by pot, sternly seal in two pots of joint yellow mud, it is that coke yellow is ceased fire that low baking temperature is calcined to blank sheet of paper, and Hou Leng takes out, and grinds to form Petiolus Trachycarpi powdered carbon;

B. the Radix Pulsatillae 20, Folium Psidii Guajavae 8, Herba Bidentis Bipinnatae 8, Folium Bambusae 6 is got by the parts by weight of formula, first use alcohol reflux, obtain extracting solution A, residue medicinal residues decoct with water extraction again, collect extracting solution and be designated as extracting solution B, extracting solution A and extracting solution B is mixed rear and is condensed into clear paste;

C. step b gained medicinal residues are dry, then pulverize, add the Petiolus Trachycarpi powdered carbon 15 of ash wood 60, the bottom of a pan ash 20 and step a gained by the parts by weight of formula, mix homogeneously, obtains mixture C;

D. by step c gained mixture C and the mixing of step b gained clear paste, then add adjuvant and conventionally make granule.

The medicine of control pig winter dysentery, its using method is: wash water open in the ratio of every pig 100 grams and gavage, or spice is fed, every day 3 times, and connect and feed 2 ~ 3 days, preventive dose reduces by half.

Embodiment 2

Prevent and treat a medicine for pig winter dysentery, it be by the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae, ash wood, Fibra Trachycarpi, the bottom of a pan ash routinely explained hereafter form; Described ash wood is the ash wood burnt till with Lignum seu Ramulus Cunninghamiae Lanceolatae, Masson Pine or chestnut.

The production method of control pig winter dysentery medicine, contains following steps:

A. get clean Fibra Trachycarpi, put in pot, cover the pot that a bore is slightly little, a piece of paper pasted by pot, sternly seal in two pots of joint yellow mud, it is that coke yellow is ceased fire that low baking temperature is calcined to blank sheet of paper, and Hou Leng takes out, and grinds to form Petiolus Trachycarpi powdered carbon;

B. the Radix Pulsatillae 30, Folium Psidii Guajavae 9, Herba Bidentis Bipinnatae 9, Folium Bambusae 7 is got by the parts by weight of formula, first use alcohol reflux, obtain extracting solution A, residue medicinal residues decoct with water extraction again, collect extracting solution and be designated as extracting solution B, extracting solution A and extracting solution B is mixed rear and is condensed into clear paste;

C. step b gained medicinal residues are dry, then pulverize, add the Petiolus Trachycarpi powdered carbon 16 of ash wood 70, the bottom of a pan ash 30 and step a gained by the parts by weight of formula, mix homogeneously, obtains mixture C;

D. by step c gained mixture C and the mixing of step b gained clear paste, then add adjuvant and conventionally make granule.

The medicine of control pig winter dysentery, its using method is: wash water open in the ratio of every pig 100 grams and gavage, or spice is fed, every day 3 times, and connect and feed 2 ~ 3 days, preventive dose reduces by half.

Embodiment 3

Prevent and treat a medicine for pig winter dysentery, it be by the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae, ash wood, Fibra Trachycarpi, the bottom of a pan ash routinely explained hereafter form; Described ash wood is the ash wood burnt till with Lignum seu Ramulus Cunninghamiae Lanceolatae, Masson Pine or chestnut.

The production method of control pig winter dysentery medicine, contains following steps:

A. get clean Fibra Trachycarpi, put in pot, cover the pot that a bore is slightly little, a piece of paper pasted by pot, sternly seal in two pots of joint yellow mud, it is that coke yellow is ceased fire that low baking temperature is calcined to blank sheet of paper, and Hou Leng takes out, and grinds to form Petiolus Trachycarpi powdered carbon;

B. the Radix Pulsatillae 40, Folium Psidii Guajavae 10, Herba Bidentis Bipinnatae 10, Folium Bambusae 8 is got by the parts by weight of formula, first use alcohol reflux, obtain extracting solution A, residue medicinal residues decoct with water extraction again, collect extracting solution and be designated as extracting solution B, extracting solution A and extracting solution B is mixed rear and is condensed into clear paste;

C. step b gained medicinal residues are dry, then pulverize, add the Petiolus Trachycarpi powdered carbon 17 of ash wood 80, the bottom of a pan ash 40 and step a gained by the parts by weight of formula, mix homogeneously, obtains mixture C;

D. by step c gained mixture C and the mixing of step b gained clear paste, then add adjuvant and conventionally make granule.

The medicine of control pig winter dysentery, its using method is: wash water open in the ratio of every pig 100 grams and gavage, or spice is fed, every day 3 times, and connect and feed 2 ~ 3 days, preventive dose reduces by half.

Classical case:

Case one: Guigang, Guangxi plant, in mid-December, 2013, has 36 Adult Pigs to occur watery diarrhea symptom in plant, rushing down excrement is just canescence, is gradually with yellow green, stench unpleasant.Abdominal distention, vomiting, the body temperature initial stage is increased to 4O ~ 41 DEG C, rushes down general rule body temperature and namely falls, thirst and liking drink, through being diagnosed as viral acute infectious disease, i.e. pig winter dysentery.The medicine that the application embodiment of the present invention one produces control pig winter dysentery is treated, and washes water open and gavages, every day 3 times, carry out strict sterilization process before and after treatment simultaneously to surrounding in the ratio of every pig 100 grams.The medication same day, the clinical symptoms of pig and mental status improvement.Medication is after 2 days, and 36 Adult Pig clinical symptom disappearance, get well, cure rate reaches 100%.After healing, do not have and recur again.

Case two: Qin Tang pig farm, Guangxi, be everlasting cold winter Mo and time in early spring generation pig winter dysentery.Do not have immunity after swine diseases of falling ill, morbidity in a year, will continue every year, and the pig morbidity of hundreds of, pig farm, sickness rate is up to 90%, and mortality rate reaches 20%.Most of sick pig (mainly big-and-middle pig) can resistance to mistake and recover appetite, but from the process of morbidity → antidiarrheal → recovery appetite → recovery body weight, and generally at about 30 ~ 40 days, to raising pigs, people and pig industry cause heavy labor service burden and economic loss.The medicine that the application embodiment of the present invention two prevents and treats pig winter dysentery is treated, and feeds in the ratio spice of every pig 100 grams, every day 3 times, carries out strict sterilization process before and after treatment to surrounding simultaneously.The medication same day, the clinical symptoms of pig and mental status improvement.Medication is after 2 days, and ill pig clinical symptom disappearance, get well, cure rate reaches 100%.After healing, do not have and recur again.

Case three: Nanning individual raiser Huang, finds 56 pigs of stable breeding, occur watery diarrhea symptom, rushing down excrement is just canescence, is gradually with yellow green, stench unpleasant.Abdominal distention, vomiting, the body temperature initial stage is increased to 4O ~ 41 DEG C, rushes down general rule body temperature and namely falls, thirst and liking drink, through being diagnosed as viral acute infectious disease, i.e. pig winter dysentery.The medicine that the application embodiment of the present invention three produces control pig winter dysentery is treated, and wash water open and gavage, or spice is fed, every day 3 times, carry out strict sterilization process before and after treatment simultaneously to surrounding in the ratio of every pig 100 grams.The medication same day, the clinical symptoms of pig and mental status improvement.Connect and feed after 2 days, 56 pig clinical symptom disappearance, get well, cure rate reaches 100%.After healing, do not have and recur again.

Case four: pig farm, Nanning, annual winter Mo and time in early spring, the medicine that application the present invention prevents and treats pig winter dysentery carries out diseases prevention, wash water open in the ratio of every pig 50 grams to gavage, or spice is fed, every day 3 times, a week feeds 2 ~ 3 days, the pig on its pig farm never must cross winter dysentery, and preventive effect is very good.

Claims (6)

1. prevent and treat the medicine of pig winter dysentery for one kind, it is characterized in that, it be by the raw material of following parts by weight routinely explained hereafter form: Radix Pulsatillae 20-40, Folium Psidii Guajavae 8-10, Herba Bidentis Bipinnatae 8-10, Folium Bambusae 6-8, ash wood 60-80, Fibra Trachycarpi 15-17, the bottom of a pan ash 20-40; Described ash wood is the ash wood burnt till with Lignum seu Ramulus Cunninghamiae Lanceolatae, Masson Pine or chestnut.

2. the medicine of control pig winter dysentery according to claim 1, it is characterized in that, the parts by weight of each raw material are: the Radix Pulsatillae 20, Folium Psidii Guajavae 8, Herba Bidentis Bipinnatae 8, Folium Bambusae 6, ash wood 60, Fibra Trachycarpi 15, the bottom of a pan ash 20.

3. the medicine of control pig winter dysentery according to claim 1, it is characterized in that, the parts by weight of each raw material are: the Radix Pulsatillae 30, Folium Psidii Guajavae 9, Herba Bidentis Bipinnatae 9, Folium Bambusae 7, ash wood 70, Fibra Trachycarpi 16, the bottom of a pan ash 30.

4. the medicine of control pig winter dysentery according to claim 1, it is characterized in that, the parts by weight of each raw material are: the Radix Pulsatillae 40, Folium Psidii Guajavae 10, Herba Bidentis Bipinnatae 10, Folium Bambusae 8, ash wood 80, Fibra Trachycarpi 17, the bottom of a pan ash 40.

5. the control pig winter dysentery medicine according to any one of claim 1-4, it is characterized in that, its production method contains following steps:

A. get clean Fibra Trachycarpi, put in pot, cover the pot that a bore is slightly little, a piece of paper pasted by pot, sternly seal in two pots of joint yellow mud, it is that coke yellow is ceased fire that low baking temperature is calcined to blank sheet of paper, and Hou Leng takes out, and grinds to form Petiolus Trachycarpi powdered carbon;

B. get the Radix Pulsatillae, Folium Psidii Guajavae, Herba Bidentis Bipinnatae, Folium Bambusae by formula, first use alcohol reflux, obtain extracting solution A, residue medicinal residues decoct with water extraction again, collect extracting solution and are designated as extracting solution B, mix rear and be condensed into clear paste by extracting solution A and extracting solution B;

C. step b gained medicinal residues are dry, then pulverize, add the Petiolus Trachycarpi powdered carbon of ash wood, the bottom of a pan ash and step a gained, mix homogeneously, obtains mixture C;

D. by step c gained mixture C and the mixing of step b gained clear paste, then add adjuvant and conventionally make granule.

6. the medicine of control pig winter dysentery according to claim 1, it is characterized in that, its using method is: wash water open in the ratio of every pig 100 grams and gavage, or spice is fed, every day 3 times, and connect and feed 2 ~ 3 days, preventive dose reduces by half.