CN105168896A

CN105168896A - Traditional Chinese medicinal composition and nursing method for treating constipation after malignant tumor chemotherapy

Info

Publication number: CN105168896A
Application number: CN201510425379.5A
Authority: CN
Inventors: 胡萍
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-07-14
Filing date: 2015-07-14
Publication date: 2015-12-23

Abstract

The invention discloses a traditional Chinese medicinal composition for treating constipation after malignant tumor chemotherapy. According to traditional Chinese medicine, constipation with intestinal dryness can occur in patients of cancers due to impairment of yin, yin deficiency and intrinsic heat after enduring illness. Chemotherapeutic drugs can enhance injury of spleen and stomach, dysfunction of the spleen and stomach, body fluid failing to distribute, fluid exhaustion failing to moisten large intestine, fluid exhaustion and heat accumulation, and poor moistening of intestines, therefore causing constipation. The traditional Chinese medicinal composition is prepared into a decoction from the following traditional Chinese medicines: hance rosewood stem or root, tulipa gesneriana, paniculigera starwort herb, stickyhair pearleverlasting herb, bigfruit phymatopsis herb, sophora davidii, dunn antiotrema root, flabellate hemipilia herb, sericea lespedeza, virgularia skeletone and angelica sinensis. Upon clinical tests, the total effective rate is 93.3%, which is much better than that in a control group which is 73.3%; and the traditional Chinese medicinal composition is low in side effects.

Description

A kind of Chinese medicine composition and care method for the treatment of constipation after malignant tumor chemotherapy

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy

Background technology

At present, chemotherapy is one of important means for the treatment of malignant tumor, and gastrointestinal reaction is untoward reaction common after chemotherapy, and wherein constipation is comparatively common, and constipation refers to that feces is excessively of a specified duration in the colon time of staying, and contained humidity reduces, and becomes dry hardening, so that not easily discharges.Some patients's symptom is comparatively serious.Even therefore some patient fears chemotherapy.The raising and the treatment plan that not only have impact on drug dose are finished on schedule, and add the misery of patient, thus have impact on therapeutic effect.Current people usually take phenolphthalein tablet and are treated, and it includes phenolphthalein, are diphenylmethane derivatives.Stimulate intestinal wall plexus nervorum, directly act on intestinal smooth, and enteral and alkaline intestinal juice meet and forms soluble sodium salt and stimulate mucous membrane of colon, promotion is wriggled and stops intestinal juice to be absorbed by intestinal wall, rapid-action, defecation after general 4-8h.There is the untoward reaction such as stomachache, diarrhoea because of even, original stomachache and allergic constitution person forbidding, and get old and weak and have loose stool history person to be cautious use of.And long-term taking phenolphthalein tablet, the loss of nutrient substance can be caused, the complication such as the unbalance low birth weight of anemia, Water-Electrolyte, resistance decline, malnutrition can be caused.We are according to chemotherapeutics impairing the spleen and stomach, transporting and transforming function of the spleen and stomach is not normal, body fluid must not four cloth, the withered large intestine that can not make moist in Tianjin, the withered accumulation of heat in Tianjin, intestinal loses and makes moist, therefore the mechanism of constipation, develops a kind of clearing away heat and moistening the bowels, purging FU-organs of regulating the flow of vital energy, preparation are convenient, cheap, has no side effect, Chinese medicine preparation that applicable crowd is wide.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy.The traditional Chinese medical science is thought: cancer patient can cause dryness of the intestine constipation because of prolonged illness impairment of YIN, yin asthenia generating intrinsic heat, deficiency of body fluid.Chemotherapeutics is impairing the spleen and stomach more, and transporting and transforming function of the spleen and stomach is not normal, and body fluid must not four cloth, the withered large intestine that can not make moist in Tianjin, the withered accumulation of heat in Tianjin, and intestinal loses and makes moist, therefore constipation.

The object of the invention is to be achieved through the following technical solutions, after this treatment malignant tumor chemotherapy, the Chinese medicine composition of constipation is made up of the Chinese medicine of following weight portion: Caulis Dalbergiae Hancei 8-12g, Flos Tulipae Gesnerianae 8-12g, Herba Stellariae paniculigerae 8-12g, Herba Clematidis Meyenianae 7-11g, Phymatopsis griffithiana (Hook.) J. Sm. 7-11g, Radix Sophorae Viciifoliae 7-11g, Radix Antiotrematis dunniani 9-13g, Herba Hemipiliae Flabellatae 9--13g, Herba Lespedezae Cuneatae 9-13g, Virgularia sp. 3-7g, Radix Angelicae Sinensis 12--16g.

Preferred: Caulis Dalbergiae Hancei 10g, Flos Tulipae Gesnerianae 10g, Herba Stellariae paniculigerae 10g, Herba Clematidis Meyenianae 9g, Phymatopsis griffithiana (Hook.) J. Sm. 9g, Radix Sophorae Viciifoliae 9g, Radix Antiotrematis dunniani 11g, Herba Hemipiliae Flabellatae 11g, Herba Lespedezae Cuneatae 11g, Virgularia sp. 5g, Radix Angelicae Sinensis 14g.

Preparation method: traditionally make decoction.

Caulis Dalbergiae Hancei, Flos Tulipae Gesnerianae, Herba Stellariae paniculigerae in side: regulating QI to expel dampness, removing food stagnancy is invigorated blood circulation; Herba Clematidis Meyenianae: promoting the circulation of QI to relieve pain, stomach invigorating antiinflammatory; Phymatopsis griffithiana (Hook.) J. Sm., Radix Sophorae Viciifoliae: heat-clearing and toxic substances removing, inducing diuresis and reducing edema, control hemorrhoidal hamorrhage toxic swelling; Radix Antiotrematis dunniani, Herba Hemipiliae Flabellatae, Herba Lespedezae Cuneatae: YIN nourishing, lung moistening are invigorated blood circulation; Virgularia sp.: removing food stagnancy is stagnant, eliminating stagnation; Radix Angelicae Sinensis: moisturize laxation.

Clinical data

1, physical data: full group 60 example, all through proved by pathology be malignant tumor.Man 30 example, female 30 example; Age 31-70 year, the median age 58 years old.Wherein 15 Lung cancer cases, hepatocarcinoma 4 example, gastric cancer 13 example, breast carcinoma 9 example, colorectal cancer 13 example, malignant lymphoma 4 example, multiple myeloma 2 example.The course of disease 1 month-3 years is not etc.All patient KPS scoring > 60 points.Patient gets rid of gut region property blocks, or previously has habitual constipation medical history.All patients all accept intravenous chemotherapy, the equal preventive use 5-HT of all patients ₃receptor antagonist granisetron emesis, treatments period generation constipation.

2, Therapeutic Method: patient is divided into two groups, treatment group and matched group, the sex of case selected by two groups, age, the tumor course of disease, tumor class and stadium, tumor histology's typing, previously treat situation, in the recent period chemotherapeutics kind and consumption, through statistical procedures there are no significant difference.Treatment group 30 example, takes Chinese medicine composition of the present invention: Caulis Dalbergiae Hancei 10g, Flos Tulipae Gesnerianae 10g, Herba Stellariae paniculigerae 10g, Herba Clematidis Meyenianae 9g, Phymatopsis griffithiana (Hook.) J. Sm. 9g, Radix Sophorae Viciifoliae 9g, Radix Antiotrematis dunniani 11g, Herba Hemipiliae Flabellatae 11g, Herba Lespedezae Cuneatae 11g, Virgularia sp. 5g, Radix Angelicae Sinensis 14g.Decocting extracting juice 300ml, point early, evening is oral; 1 dose/d, 5 doses/week, matched group 30 example, phenolphthalein (phenolphthalein tablets) 100mg per os hora somni.

3, evaluation criterion: constipation diagnostic criteria is: (1) defecation frequency reduces; (2) difficult defecation or have row to feel not to the utmost; (3) feces is dry and hard hard.If 1 ~ 3 possess wherein 1 or combination can be diagnosed as constipation.Usually be reduced to master with stool, generally every 2 ~ 3 days or longer time defecation be constipation 1 time.Criterion of therapeutical effect, by defecation in " Chinese medical disease Standardization of diagnosis and curative effect " 2 days 1 time, just matter turns profit, and defecation is unobstructed, short-term without recurrence for effective; Defecation 1 time in 3 days, just matter turns profit, and it is effective that defecation owes unobstructed; Symptom is invalid without being improved as.Effective adding is effectively total effective rate.

4, therapeutic outcome: effective 20 examples for the treatment of group, effective 8 examples, invalid 2 examples, total effective rate 93.3%; Effective 12 examples of matched group, effective 10 examples, invalid 8 examples, total effective rate 73.3%.Two groups of comparing differences have significance, and treatment group is obviously better than illumination.

5, untoward reaction: treatment group loose stool 1 example, stomachache 1 example, mild symptoms; Matched group: stomachache 5 example, loose stool 3 example, mild symptoms, does not all affect continuation medication.

Detailed description of the invention

Embodiment one takes: Caulis Dalbergiae Hancei 8g, Flos Tulipae Gesnerianae 8g, Herba Stellariae paniculigerae 8g, Herba Clematidis Meyenianae 7g, Phymatopsis griffithiana (Hook.) J. Sm. 7g, Radix Sophorae Viciifoliae 7g, Radix Antiotrematis dunniani 9g, Herba Hemipiliae Flabellatae 9g, Herba Lespedezae Cuneatae 9g, Virgularia sp. 3g, Radix Angelicae Sinensis 12g, decocting extracting juice 300ml, point early, evening is oral; 1 dose/d.

Embodiment two takes: Caulis Dalbergiae Hancei 10g, Flos Tulipae Gesnerianae 10g, Herba Stellariae paniculigerae 10g, Herba Clematidis Meyenianae 9g, Phymatopsis griffithiana (Hook.) J. Sm. 9g, Radix Sophorae Viciifoliae 9g, Radix Antiotrematis dunniani 11g, Herba Hemipiliae Flabellatae 11g, Herba Lespedezae Cuneatae 11g, Virgularia sp. 5g, Radix Angelicae Sinensis 14g, decocting extracting juice 300ml, point early, evening is oral; 1 dose/d.

Embodiment three takes: Caulis Dalbergiae Hancei 12g, Flos Tulipae Gesnerianae 12g, Herba Stellariae paniculigerae 12g, Herba Clematidis Meyenianae 11g, Phymatopsis griffithiana (Hook.) J. Sm. 11g, Radix Sophorae Viciifoliae 11g, Radix Antiotrematis dunniani 13g, Herba Hemipiliae Flabellatae 13g, Herba Lespedezae Cuneatae 13g, Virgularia sp. 7g, Radix Angelicae Sinensis 16g, decocting extracting juice 300ml, point early, evening is oral; 1 dose/d.

Claims

1. treat a Chinese medicine composition for constipation after malignant tumor chemotherapy, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Caulis Dalbergiae Hancei 8-12g, Flos Tulipae Gesnerianae 8-12g, Herba Stellariae paniculigerae 8-12g, Herba Clematidis Meyenianae 7-11g, Phymatopsis griffithiana (Hook.) J. Sm. 7-11g, Radix Sophorae Viciifoliae 7-11g, Radix Antiotrematis dunniani 9-13g, Herba Hemipiliae Flabellatae 9--13g, Herba Lespedezae Cuneatae 9-13g, Virgularia sp. 3-7g, Radix Angelicae Sinensis 12--16g.

2. a kind of Chinese medicine composition for the treatment of constipation after malignant tumor chemotherapy as claimed in claim 1, is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: preferred: Caulis Dalbergiae Hancei 10g, Flos Tulipae Gesnerianae 10g, Herba Stellariae paniculigerae 10g, Herba Clematidis Meyenianae 9g, Phymatopsis griffithiana (Hook.) J. Sm. 9g, Radix Sophorae Viciifoliae 9g, Radix Antiotrematis dunniani 11g, Herba Hemipiliae Flabellatae 11g, Herba Lespedezae Cuneatae 11g, Virgularia sp. 5g, Radix Angelicae Sinensis 14g.