CN105168597A - Externally-applied pharmaceutical composition used for treating chilblain and having function of dispelling paresthesia, externally-applied ointment for treating chilblain and preparation method of externally-applied ointment - Google Patents
Externally-applied pharmaceutical composition used for treating chilblain and having function of dispelling paresthesia, externally-applied ointment for treating chilblain and preparation method of externally-applied ointment Download PDFInfo
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- CN105168597A CN105168597A CN201510499370.9A CN201510499370A CN105168597A CN 105168597 A CN105168597 A CN 105168597A CN 201510499370 A CN201510499370 A CN 201510499370A CN 105168597 A CN105168597 A CN 105168597A
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Abstract
The invention provides an externally-applied pharmaceutical composition used for treating chilblain and having a function of dispelling paresthesia. The externally-applied pharmaceutical composition is prepared from the following raw materials: safflower, flos genkwa, radix arnebiae seu lithospermi, motherwort, flos daturae, pearl, borneol, cinnamon, notoginseng, paniculate swallowwort root, sodium chloride, angelica dahurica, radix sophorae flavescentis, fructus cnidii, radix achyranthis bidentatae, and Chinese angelica. The invention also provides an externally-applied ointment for treating chilblain and a preparation method thereof. The externally-applied ointment has the following beneficial effects of efficacies of invigorating blood circulation to dredge collaterals, removing swelling and relieving pain, and relieving itching and dispelling paresthesia.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicine preparation, particularly relate to a kind of there is paresthesia function of dispelling treatment chilblain externally-applied medicinal composition, treatment chilblain external-applied ointment and preparation method thereof.
Background technology
Chilblain, after body is subject to cold invasion and attack, occurs in localized erythema's diseases associated with inflammation at tip position.It is low temperature above freezing combines caused by (clammy environment) exposure a kind of limitation imflammatory erythema infringement with high humility.Easily occur in the clammy environment of temperature less than 10 DEG C.Position is many at auricle, the place such as hands, foot, and local is rubescent, blue, swelling, and pain of itching, gets blister sometimes, rotten to the corn, ulceration, and knot is silly.
In southern mountain area, chilblain in winter is especially common.Southern area winter, without heating installation, mountain area height above sea level, to have a humid climate, and also needs work winter, does not wear footwear or trick and be directly exposed to and freeze in water during work; Many children whole winter barefoot or wear slippers, so south mild chilblain in winter is very common.
Some chilblain patient there will be various sense of discomfort, also there will be abnormal sensory with regard to affected part, as various senses of discomfort such as swelling sense, inconvenient activity, perceptual distortion.
Need a kind of Therapeutic Method of better chilblain.
Summary of the invention
An object of the present invention is to provide a kind for the treatment of chilblain externally-applied medicinal composition with paresthesia function of dispelling
withthe paresthesia symptom that treatment chilblain and chilblain are brought.This object is achieved through the following technical solutions:
There is the treatment chilblain externally-applied medicinal composition of paresthesia function of dispelling, be made up of following raw materials according by weight: Flos Carthami 80 ~ 10
0 weight portion, Flos Genkwa 80 ~ 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 ~ 30 weight portion, Herba Leonuri 20 ~ 30 weight portion, Flos Daturae 20 ~ 30 weight portion, Margarita 20 ~ 30 weight portion; Borneolum Syntheticum 10 ~ 15 weight portion, Cortex Cinnamomi 10 ~ 15 weight portion, Radix Notoginseng 10 ~ 15 weight portion, Radix Cynanchi Paniculati 10 ~ 15 weight portion, sodium chloride 5 ~ 10 weight portion, the Radix Angelicae Dahuricae 5 ~ 10 weight portion, Radix Sophorae Flavescentis 5 ~ 10 weight portion, Fructus Cnidii 5 ~ 10 weight portion; Radix Achyranthis Bidentatae 20 ~ 30 weight portion, Radix Angelicae Sinensis 20 ~ 30 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 90 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion.
An object of the present invention is to provide a kind of external-applied ointment for the treatment of chilblain, and this object is achieved through the following technical solutions:
The external-applied ointment for the treatment of chilblain, is made up of following raw materials according by weight: Flos Carthami 80 ~ 10
0 weight portion, Flos Genkwa 80 ~ 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 ~ 30 weight portion, Herba Leonuri 20 ~ 30 weight portion, Flos Daturae 20 ~ 30 weight portion, Margarita 20 ~ 30 weight portion; Borneolum Syntheticum 10 ~ 15 weight portion, Cortex Cinnamomi 10 ~ 15 weight portion, Radix Notoginseng 10 ~ 15 weight portion, Radix Cynanchi Paniculati 10 ~ 15 weight portion, sodium chloride 5 ~ 10 weight portion, the Radix Angelicae Dahuricae 5 ~ 10 weight portion, Radix Sophorae Flavescentis 5 ~ 10 weight portion, Fructus Cnidii 5 ~ 10 weight portion; Radix Achyranthis Bidentatae 20 ~ 30 weight portion, Radix Angelicae Sinensis 20 ~ 30 weight portion; Oleum Camelliae 1500 ~ 2000 weight portion, Cera Flava 300 ~ 600 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion; Oleum Camelliae 1500 weight portion, Cera Flava 350 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 9
0 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion; Oleum Camelliae 1800 weight portion, Cera Flava 600 weight portion.
Preferably, be made up of following raw materials according by weight: Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion; Oleum Camelliae 2000 weight portion, Cera Flava 450 weight portion.
An object of the present invention is to provide the manufacture method of the external-applied ointment of aforementioned therapies chilblain, and this object is achieved through the following technical solutions:
The manufacture method of the external-applied ointment for the treatment of chilblain, comprises the following steps: Margarita powder is broken into fine powder, crosses 200 ~ 300 mesh sieves; Borneolum Syntheticum, sodium chloride, Radix Notoginseng three taste raw material powder are broken into fine powder, cross 150 ~ 200 mesh sieves; Oleum Camelliae be heated to and keep oil temperature at 180 ~ 200 ° of C, adding Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, explode withered or be deep-fried rear removing medicinal residues; Oil temperature be down to and remain on 150 ~ 160 ° of C, then adding Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Flos Daturae, Radix Notoginseng, explode withered or be deep-fried rear removing medicinal residues; When oil temperature is cooled to 80 ~ 120 ° of C, add Cera Flava, stir and help Cera Flava to melt; Oil temperature be down to and remain on 50 ~ 70 ° of C, adding Borneolum Syntheticum, sodium chloride, Margarita, stir evenly, let cool, to obtain final product.
Preferably, further comprising the steps of: Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis powder are broken into coarse powder, cross 50 ~ 100 mesh sieves.
Preferably, further comprising the steps of: by Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Flos Daturae chopping.
An object of the present invention is to provide the treatment chilblain external hot compress paster with paresthesia function of dispelling, and this object is achieved through the following technical solutions:
Have the treatment chilblain external hot compress paster of paresthesia function of dispelling, the following raw materials according comprised by weight is made: Flos Carthami 80 ~ 10
0 weight portion, Flos Genkwa 80 ~ 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 ~ 30 weight portion, Herba Leonuri 20 ~ 30 weight portion, Flos Daturae 20 ~ 30 weight portion, Margarita 20 ~ 30 weight portion; Cortex Cinnamomi 10 ~ 15 weight portion, Radix Notoginseng 10 ~ 15 weight portion, Radix Cynanchi Paniculati 10 ~ 15 weight portion, the Radix Angelicae Dahuricae 5 ~ 10 weight portion, Radix Sophorae Flavescentis 5 ~ 10 weight portion, Fructus Cnidii 5 ~ 10 weight portion; Radix Achyranthis Bidentatae 20 ~ 30 weight portion, Radix Angelicae Sinensis 20 ~ 30 weight portion; Iron powder 3000 ~ 6000 weight portion, active carbon 300 ~ 600 weight portion, sodium chloride 100 ~ 300 weight portion.
Preferably, the following raw materials according comprised by weight is made: Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion; Iron powder 3000 weight portion, active carbon 400 weight portion, sodium chloride 250 weight portion.
Alternatively, the following raw materials according comprised by weight is made: Flos Carthami 90 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion; Iron powder 4500 weight portion, active carbon 600 weight portion, sodium chloride 120 weight portion.
Alternatively, the following raw materials according comprised by weight is made: Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion; Iron powder 6000 weight portion, active carbon 300 weight portion, sodium chloride 200 weight portion.
Preferably, Borneolum Syntheticum 10 ~ 15 weight portion is also comprised.
An object of the present invention is to provide the aforesaid manufacture method with the treatment chilblain external hot compress paster of paresthesia function of dispelling, and this object is achieved through the following technical solutions:
Margarita powder is broken into fine powder, crosses 200 ~ 300 mesh sieves; Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Flos Daturae, Cortex Cinnamomi, Radix Notoginseng, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis 13 taste raw material powder are broken into fine powder, cross 150 ~ 200 mesh sieves; Above 14 taste raw materials, iron powder, active carbon and sodium chloride are mixed to get mixture, to the sealing of described mixture air-isolation, and get final product.
Preferably, before sealing, use gauze according to predetermined weight part, subpackage is carried out to described mixture, after seal again.
Of the present invention group of thing mechanism of action is:
Monarch drug:
Flos Carthami, temperature, GUIXIN, Liver Channel, promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain;
Flos Genkwa, pungent, warm, poisonous, return lung, spleen, kidney channel, removing fluid-retention by purgation, external parasite killing treat skin ulcer.
Ministerial drug:
Radix Arnebiae (Radix Lithospermi), sweet, salty, cold, GUIXIN, Liver Channel, clearing away heat and cooling blood, promoting blood circulation and detoxication, rash speckle removing;
Herba Leonuri, bitter, pungent, be slightly cold, return liver, pericardium, urinary bladder channel, promoting blood flow to regulate menstruation, inducing diuresis to remove edema, heat-clearing and toxic substances removing;
Flos Daturae, pungent, warm, poisonous, return lung, Liver Channel, antiasthmatic-antitussive, spasmolytic analgesic therapy;
Margarita, salty, cold, GUIXIN, Liver Channel, arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, moistening skin and eliminating spot.
Adjuvant drug:
Borneolum Syntheticum, bitter, be slightly cold, GUIXIN, spleen, lung meridian, refreshment of having one's ideas straightened out, clearing away heat to alleviate pain;
Cortex Cinnamomi, pungent, sweet, hot greatly, return kidney, spleen, the heart, Liver Channel, mend fire supporing yang, guiding fire to origin, dispersing cold for relieving pain, promoting the flow of QI-blood by warming the meridian;
Radix Notoginseng, micro-hardship, temperature, return liver, stomach warp, dissipating blood stasis hemostasis, subduing swelling and relieving pain;
Radix Cynanchi Paniculati, temperature, returns liver, stomach warp, dispels the wind, removing dampness, pain relieving, antipruritic;
Sodium chloride, salty, cold, nontoxic, relieve inflammation or internal heat, removing heat from blood, removing toxic substances, softening the hard mass, parasite killing, antipruritic, sodium chloride can substitute with Sal in the present invention;
The Radix Angelicae Dahuricae, temperature, returns stomach, large intestine, lung meridian, the cold expelling that induces sweat, wind-expelling pain-stopping, a surname's clearing the nasal passage, dampness leukorrhagia stopping, detumescence and apocenosis;
Radix Sophorae Flavescentis, cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, heat clearing and damp drying, parasite killing, diuresis;
Fructus Cnidii, bitter, temperature, slightly poisonous, return kidney channel, dampness is dispeled the wind, killing parasites for relieving itching, warming the kidney to invigorate YANG.
Make medicine:
Radix Achyranthis Bidentatae, sweet, sour, flat, return liver, kidney channel, eliminating blood stasis and inducing menstruation, invigorating the liver and kidney, bone and muscle strengthening, inducing diuresis for treating stranguria syndrome, conducting blood to flow downwards;
Radix Angelicae Sinensis, sweet, pungent, warm, return liver, the heart, spleen channel, enrich blood invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.
Beneficial effect of the present invention is:
The effect of easypro network, reducing swelling and alleviating pain, the antipruritic sense of discomfort that disappears of invigorating blood circulation.Be applicable to treat various mild chilblain and economy of drawing materials.
there is the treatment chilblain external of paresthesia function of dispellinghot compress paster adds thermotherapy, and drug effect continuingly acts on affected part, and effect more.
The optional using method of the present invention: will
there is the treatment chilblain externally-applied medicinal composition of paresthesia function of dispellingcarrying out decocting in water and boil liquid to obtain, washing affected part with boiling vacuole, or boil the towel hot compress of liquid in patient with adhesional wetting; The external-applied ointment for the treatment of chilblain is consistent with common ointment using method.Use amount, frequency of utilization elect according to individual concrete condition.
there is the treatment chilblain of paresthesia function of dispellingthe using method of external hot compress paster, under several to plaster jog before using, plaster spreads on affected part, can pad clean ventilative thing, preferably with gauze to prevent from scalding between skin and plaster, be fixed plaster afterwards, the mode that gauze periphery can be selected to be wound around is fixed.
The present invention is through 6 verification experimental verifications among the people, and Be very effective, effective percentage reaches 100%, remission 50% in 1 day, and recovery from illness in 5 days reaches 67%, and following is the present invention's 3 specific experiment examples.
Experimental example 1
Lee, female, winter has pointed chilblain, and have swelling sense, finger motion control insensitive, use
there is the treatment chilblain of paresthesia function of dispellingexternally-applied medicinal composition embathes, and embathes 2 every day, alleviates after one day, substantially disappears after five days, fully recovers after 10 days, uncomfortable without other.
Experimental example 2
Zhang, man, winter, ear played chilblain, and anesthesia sense, use the external-applied ointment for the treatment of chilblain, one day twice, onset after a day, eliminates two days later, fully recovers after five days.
Experimental example 3
Witch, female, have after the long chilblain of foot disappearance sense and dumb to the control of foot, use
there is the treatment chilblain of paresthesia function of dispellingwrap up with gauze, continue 5 hours behind external hot compress paster coating affected part, within one day one, change, within one day, sensation takes a turn for the better, paresthesia elimination in three days, recovery from illness in five days.
It should be noted that the present invention forbids eating, and for the careful use of anemia of pregnant woman.
Detailed description of the invention
Below by way of specific embodiment, the present invention is described in detail.
Embodiment 1
The treatment chilblain externally-applied medicinal composition got and there is paresthesia function of dispelling is joined: Flos Carthami 8 according to the raw material of following parts by weight
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion.
Embodiment 2
There is the treatment chilblain externally-applied medicinal composition of paresthesia function of dispelling, be made up of following raw materials according by weight: Flos Carthami 90 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion.
Embodiment 3
The treatment chilblain externally-applied medicinal composition got and there is paresthesia function of dispelling is joined: Flos Carthami 10 according to the raw material of following parts by weight
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion.
Embodiment 4
The external-applied ointment for the treatment of chilblain is made up of following raw materials according by weight: the treatment chilblain externally-applied medicinal composition with paresthesia function of dispelling of any embodiment in embodiment 1 ~ 3, Oleum Camelliae 1500 ~ 2000 weight portion, Cera Flava 300 ~ 600 weight portion.
Embodiment 5
The external-applied ointment for the treatment of chilblain is made up of following raw materials according by weight:
Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion; Oleum Camelliae 1500 weight portion, Cera Flava 350 weight portion.
Embodiment 6
The external-applied ointment for the treatment of chilblain is made up of following raw materials according by weight:
Flos Carthami 9
0 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion; Oleum Camelliae 1800 weight portion, Cera Flava 600 weight portion.
Embodiment 7
The external-applied ointment for the treatment of chilblain is made up of following raw materials according by weight:
Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion; Oleum Camelliae 2000 weight portion, Cera Flava 450 weight portion.
Embodiment 8
The manufacture method of the external-applied ointment for the treatment of chilblain, comprises the following steps:
Margarita powder is broken into fine powder, crosses 200 ~ 300 mesh sieves;
Borneolum Syntheticum, sodium chloride, Radix Notoginseng three taste raw material powder are broken into fine powder, cross 150 ~ 200 mesh sieves;
By Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Flos Daturae, Margarita, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, the raw material cutting of Radix Angelicae Sinensis 13 taste or pulverizing, the time that the contact surface increasing 13 taste raw materials expends to reduce later step; Wherein Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis powder are broken into coarse powder, cross 50 ~ 100 mesh sieves.
Oleum Camelliae be heated to and keep oil temperature at 180 ~ 200 ° of C, adding Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, eight taste raw materials exploded withered or be deep-fried rear removing medicinal residues and obtain the first fried liquid;
First fried liquid temp be down to and remained on 150 ~ 160 ° of C, then adds Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Flos Daturae, Radix Notoginseng five tastes raw material, five tastes raw material exploded withered or be deep-fried rear removing medicinal residues;
When oil temperature is cooled to 80 ~ 120 ° of C, add Cera Flava, stir and help Cera Flava to melt;
Oil temperature be down to and remain on 50 ~ 70 ° of C, adding Borneolum Syntheticum, sodium chloride, Margarita, stir evenly, let cool, to obtain final product.
Particularly, Oleum Camelliae carries out, in frying process, can concentrating and adding raw material to raw material, is progressively skimmed being deep-fried fried withered medicinal residues; Also can classify and add raw material in batches, the raw material of same batch is substantially all deep-fried fried withered rear filtration, leaves filtrate and carries out next batch frying.
The preparation method of embodiment 8 can be used for the preparation of the external-applied ointment of the treatment chilblain of embodiment 4,5,6,7.
Embodiment 9
The treatment chilblain external hot compress paster with paresthesia function of dispelling is made up of following raw materials according by weight:
Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion; Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion; Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion; Iron powder 3000 weight portion, active carbon 400 weight portion, sodium chloride 250 weight portion.
Embodiment 10
The treatment chilblain external hot compress paster with paresthesia function of dispelling is made up of following raw materials according by weight:
Flos Carthami 90 weight portion, Flos Genkwa 10
0 weight portion; Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion; Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion; Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion; Iron powder 4500 weight portion, active carbon 600 weight portion, sodium chloride 120 weight portion.
Embodiment 11
The treatment chilblain external hot compress paster with paresthesia function of dispelling is made up of following raw materials according by weight:
Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion; Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion; Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion; Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion; Iron powder 6000 weight portion, active carbon 300 weight portion, sodium chloride 200 weight portion.
Embodiment 12
The treatment chilblain external hot compress paster with paresthesia function of dispelling is made up of following raw materials according by weight:
Treat in embodiment 9,10 or 11 on the basis of the external hot compress paster of chilblain, also comprise Borneolum Syntheticum 10 ~ 15 weight portion.
Embodiment 13
There is the manufacture method of the treatment chilblain external hot compress paster of paresthesia function of dispelling, comprise the following steps:
Margarita powder is broken into fine powder, crosses 200 ~ 300 mesh sieves;
Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Herba Leonuri, Flos Daturae, Cortex Cinnamomi, Radix Notoginseng, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis 14 taste raw material powder are broken into fine powder, cross 150 ~ 200 mesh sieves;
Above 14 taste raw materials, iron powder, active carbon and sodium chloride are mixed to get mixture;
To the sealing of described mixture air-isolation, and to get final product.
Preferably, before sealing, use gauze according to predetermined weight part, subpackage is carried out to described mixture, after seal again.
The preparation method of embodiment 13 can be used for the preparation with the treatment chilblain external hot compress paster of paresthesia function of dispelling of embodiment 9,10,11.
In various embodiments of the present invention, mentioned raw material all preferably meets the raw material of Pharmacopoeia of the People's Republic of China quality standard.
Above-described embodiment, the just one of the present invention's more preferably detailed description of the invention, the usual change that those skilled in the art carries out within the scope of technical solution of the present invention and replacing all should be included in protection scope of the present invention.
Claims (10)
1. there is a treatment chilblain externally-applied medicinal composition for paresthesia function of dispelling, it is characterized in that, be made up of following raw materials according by weight: Flos Carthami 80 ~ 10
0 weight portion, Flos Genkwa 80 ~ 10
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 20 ~ 30 weight portion, Herba Leonuri 20 ~ 30 weight portion, Flos Daturae 20 ~ 30 weight portion, Margarita 20 ~ 30 weight portion;
Borneolum Syntheticum 10 ~ 15 weight portion, Cortex Cinnamomi 10 ~ 15 weight portion, Radix Notoginseng 10 ~ 15 weight portion, Radix Cynanchi Paniculati 10 ~ 15 weight portion, sodium chloride 5 ~ 10 weight portion, the Radix Angelicae Dahuricae 5 ~ 10 weight portion, Radix Sophorae Flavescentis 5 ~ 10 weight portion, Fructus Cnidii 5 ~ 10 weight portion;
Radix Achyranthis Bidentatae 20 ~ 30 weight portion, Radix Angelicae Sinensis 20 ~ 30 weight portion.
2. the treatment chilblain externally-applied medicinal composition with paresthesia function of dispelling according to claim 1, is characterized in that, be made up of following raw materials according by weight: Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion;
Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion;
Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion.
3. the treatment chilblain externally-applied medicinal composition with paresthesia function of dispelling according to claim 1, is characterized in that, be made up of following raw materials according by weight: Flos Carthami 9
0 weight portion, Flos Genkwa 10
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion;
Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion;
Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion.
4. the treatment chilblain externally-applied medicinal composition with paresthesia function of dispelling according to claim 1, is characterized in that, be made up of following raw materials according by weight: Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion;
Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion;
Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion.
5. treat an external-applied ointment for chilblain, it is characterized in that, be made up of following raw materials according by weight:
Flos Carthami 80 ~ 10
0 weight portion, Flos Genkwa 80 ~ 10
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 20 ~ 30 weight portion, Herba Leonuri 20 ~ 30 weight portion, Flos Daturae 20 ~ 30 weight portion, Margarita 20 ~ 30 weight portion;
Borneolum Syntheticum 10 ~ 15 weight portion, Cortex Cinnamomi 10 ~ 15 weight portion, Radix Notoginseng 10 ~ 15 weight portion, Radix Cynanchi Paniculati 10 ~ 15 weight portion, sodium chloride 5 ~ 10 weight portion, the Radix Angelicae Dahuricae 5 ~ 10 weight portion, Radix Sophorae Flavescentis 5 ~ 10 weight portion, Fructus Cnidii 5 ~ 10 weight portion;
Radix Achyranthis Bidentatae 20 ~ 30 weight portion, Radix Angelicae Sinensis 20 ~ 30 weight portion;
Oleum Camelliae 1500 ~ 2000 weight portion, Cera Flava 300 ~ 600 weight portion.
6. the external-applied ointment for the treatment of chilblain according to claim 5, is characterized in that, is made up of following raw materials according by weight: Flos Carthami 8
0 weight portion, Flos Genkwa 9
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 20 weight portion, Herba Leonuri 20 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion;
Borneolum Syntheticum 10 weight portion, Cortex Cinnamomi 12 weight portion, Radix Notoginseng 10 weight portion, Radix Cynanchi Paniculati 15 weight portion, sodium chloride 5 weight portion, the Radix Angelicae Dahuricae 7 weight portion, Radix Sophorae Flavescentis 7 weight portion, Fructus Cnidii 10 weight portion;
Radix Achyranthis Bidentatae 25 weight portion, Radix Angelicae Sinensis 25 weight portion;
Oleum Camelliae 1500 weight portion, Cera Flava 350 weight portion.
7. the external-applied ointment for the treatment of chilblain according to claim 5, is characterized in that, is made up of following raw materials according by weight:
Flos Carthami 90 weight portion, Flos Genkwa 10
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 25 weight portion, Herba Leonuri 25 weight portion, Flos Daturae 30 weight portion, Margarita 30 weight portion;
Borneolum Syntheticum 12 weight portion, Cortex Cinnamomi 15 weight portion, Radix Notoginseng 12 weight portion, Radix Cynanchi Paniculati 10 weight portion, sodium chloride 7 weight portion, the Radix Angelicae Dahuricae 10 weight portion, Radix Sophorae Flavescentis 10 weight portion, Fructus Cnidii 5 weight portion;
Radix Achyranthis Bidentatae 20 weight portion, Radix Angelicae Sinensis 30 weight portion;
Oleum Camelliae 1800 weight portion, Cera Flava 600 weight portion.
8. the external-applied ointment for the treatment of chilblain according to claim 5, is characterized in that, is made up of following raw materials according by weight:
Flos Carthami 10
0 weight portion, Flos Genkwa 8
0 weight portion;
Radix Arnebiae (Radix Lithospermi) 30 weight portion, Herba Leonuri 30 weight portion, Flos Daturae 25 weight portion, Margarita 25 weight portion;
Borneolum Syntheticum 15 weight portion, Cortex Cinnamomi 10 weight portion, Radix Notoginseng 15 weight portion, Radix Cynanchi Paniculati 12 weight portion, sodium chloride 10 weight portion, the Radix Angelicae Dahuricae 5 weight portion, Radix Sophorae Flavescentis 5 weight portion, Fructus Cnidii 7 weight portion;
Radix Achyranthis Bidentatae 30 weight portion, Radix Angelicae Sinensis 20 weight portion;
Oleum Camelliae 2000 weight portion, Cera Flava 450 weight portion.
9. treat a manufacture method for the external-applied ointment of chilblain described in claims 5 to 8, it is characterized in that, comprise the following steps:
Margarita powder is broken into fine powder, crosses 200 ~ 300 mesh sieves;
Borneolum Syntheticum, sodium chloride, Radix Notoginseng, three taste raw material powders are broken into fine powder, cross 150 ~ 200 mesh sieves;
Oleum Camelliae be heated to and keep oil temperature at 180 ~ 200 ° of C, adding Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis, explode withered or be deep-fried rear removing medicinal residues;
Oil temperature be down to and remain on 150 ~ 160 ° of C, then adding Flos Carthami, Flos Genkwa, Radix Arnebiae (Radix Lithospermi), Flos Daturae, Radix Notoginseng, explode withered or be deep-fried rear removing medicinal residues;
When oil temperature is cooled to 80 ~ 120 ° of C, add Cera Flava, stir and help Cera Flava to melt;
Oil temperature be down to and remain on 50 ~ 70 ° of C, adding Borneolum Syntheticum, sodium chloride, Margarita, stir evenly, let cool, to obtain final product.
10. the manufacture method of the external-applied ointment for the treatment of chilblain according to claim 9, is characterized in that, further comprising the steps of: Herba Leonuri, Cortex Cinnamomi, Radix Cynanchi Paniculati, the Radix Angelicae Dahuricae, Radix Sophorae Flavescentis, Fructus Cnidii, Radix Achyranthis Bidentatae, Radix Angelicae Sinensis powder are broken into coarse powder, cross 50 ~ 100 mesh sieves.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510499370.9A CN105168597A (en) | 2015-08-15 | 2015-08-15 | Externally-applied pharmaceutical composition used for treating chilblain and having function of dispelling paresthesia, externally-applied ointment for treating chilblain and preparation method of externally-applied ointment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510499370.9A CN105168597A (en) | 2015-08-15 | 2015-08-15 | Externally-applied pharmaceutical composition used for treating chilblain and having function of dispelling paresthesia, externally-applied ointment for treating chilblain and preparation method of externally-applied ointment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105168597A true CN105168597A (en) | 2015-12-23 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1444976A (en) * | 2003-04-16 | 2003-10-01 | 王朝岭 | Preparation of Chinese herbal medicine for treating cold injury, various indurations and swelling, pain as well as its preparing method |
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2015
- 2015-08-15 CN CN201510499370.9A patent/CN105168597A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1444976A (en) * | 2003-04-16 | 2003-10-01 | 王朝岭 | Preparation of Chinese herbal medicine for treating cold injury, various indurations and swelling, pain as well as its preparing method |
Non-Patent Citations (3)
| Title |
|---|
| 周永坤: "《实用中医外科金方》", 30 April 2008, 中医古籍出版社 * |
| 张彦祥: "中药外敷治疗冻疮46例", 《中医外治杂志》 * |
| 李伯玲: "冻疮汤组方分析", 《河南中医药学刊》 * |
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