CN105166562A - Rumen-bypass folic acid additive for dairy cattle and preparation method of rumen-bypass folic acid additive - Google Patents
Rumen-bypass folic acid additive for dairy cattle and preparation method of rumen-bypass folic acid additive Download PDFInfo
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- CN105166562A CN105166562A CN201510649038.6A CN201510649038A CN105166562A CN 105166562 A CN105166562 A CN 105166562A CN 201510649038 A CN201510649038 A CN 201510649038A CN 105166562 A CN105166562 A CN 105166562A
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Abstract
A rumen-bypass folic acid additive for dairy cattle is prepared from raw materials in parts by mass as follows: 860-900 parts of folic acid, 30-50 parts of hydroxypropyl methyl cellulose, 15 parts of trimellitic anhydride, 15 parts of anhydrous sodium acetate, 40-60 parts of magnesium stearate, 15 parts of 37% hydrochloric acid and 150 parts of glacial acetic acid. A preparation method of the additive comprises the following steps: (1), glacial acetic acid, part of hydroxypropyl methyl cellulose, trimellitic anhydride, anhydrous sodium acetate and 37% hydrochloric acid are firstly taken to synthesize hydroxypropyl methyl cellulose trimellitate as a wall material; then part of hydroxypropyl methyl cellulose, pure water and 95% ethanol are taken to prepare a hydroxypropyl methyl cellulose solution; folic acid, magnesium stearate and the hydroxypropyl methyl cellulose solution are taken to prepare particles with the size of 0.6-1.25 mm, and the particles are taken as core materials; finally, the core materials are transferred into a coating machine, the wall material is dissolved under certain conditions and sprayed into a coating chamber of the coating machine for coating the core materials, and the rumen-bypass folic acid additive for the dairy cattle is prepared.
Description
Technical field
The present invention relates to field of feed additive technology, be specifically related to a kind of feed addictive improving feed digestion utilization rate in raising dairy cattle, relate to the preparation method of rumen bypass folic acid additive simultaneously.
Background technology
Folic acid participates in purine, pyrimidine, the synthesis of choline and some amino acid whose metabolism in animal body by the transfer of one carbon unit.Folic acid as a kind of B family vitamin, with mammal energy i (in vivo) and amino acid metabolism closely related, especially methylate with DNA and RNA closely related.In animal body, folic acid deficiency can make the biosynthesis block of purine and pyrimidine, and nucleic acid forms deficiency, makes erythrocytic growth rest on the megalocyte stage, causes macrocytic anemia; Also affect the formation of blood middle leukocytes simultaneously, cause blood platelet and Neuroleptic Leukocytopenia.Folic acid is also required for maintaining the normal of function of immune system.Classical theory (NRC, 2001) thinks that microorganism can synthesize the folic acid required for animal in ruminant tumor gastric, but, in the last few years along with cultivation and the seed selection of high-yield variety, animal productiong potentiality are more and more higher, also higher to the demand of folic acid, especially high yield cow.Foreign study document announcement, high yield cow (daily output 30kg milk) to the demand of folic acid up to 35 ~ 45mg/d, and NRC(2001) think that riboflavin demand is 35mg/d.Therefore, Supplement of folic acid is needed for high yield cow, but, the folic acid more than 95% directly added in daily ration in cud degrade by rumen microorganism.For this reason, by succeeding in developing rumen bypass folic acid additive, mainly making folic acid rumen bypass, digesting and assimilating at small intestine, then play its effect, thus improve the digestive utilization ratio of feed, improve the production performance of high yield cow.
Summary of the invention
The invention provides a kind of milk cow rumen bypass folic acid additive, it is a kind of feed addictive improving feed digestion utilization rate, meanwhile, and the preparation method of the open milk cow rumen bypass folic acid additive of the present invention.
Milk cow rumen bypass folic acid additive of the present invention is formulated by the raw material of following mass parts: folic acid 860 ~ 900, hydroxypropyl methylcellulose 30 ~ 50, trimellitic anhydride 15, anhydrous sodium acetate 15, the hydrochloric acid 15 of dolomol 40 ~ 60,37%, glacial acetic acid 150.Described hydroxypropyl methylcellulose, trimellitic anhydride, dolomol will meet food grade additives standard; Described folic acid meets feed grade additive standard; Described glacial acetic acid, anhydrous sodium acetate and concentrated hydrochloric acid meet analyzes pure and mild chemically pure reagent standard.
The raw material of the preferred following mass parts of milk cow rumen bypass folic acid additive of the present invention is formulated: folic acid 900, hydroxypropyl methylcellulose 30, trimellitic anhydride 15, anhydrous sodium acetate 15, the hydrochloric acid 15 of dolomol 40,37%, glacial acetic acid 150.
The preparation method of milk cow rumen bypass folic acid additive of the present invention, comprises the steps:
(1) synthesize HPMCT the hydroxypropyl methylcellulose of 150 parts, glacial acetic acid and raw material components 90% is added to be furnished with in the container of reflux condensate device, control temperature 90 DEG C, it is made to dissolve completely, add trimellitic anhydride 15 parts again, anhydrous sodium acetate 15 parts, insulation reaction 10 hours, by mass volume ratio 50 parts of pure water cessation reactions, and in reactant liquor, add the hydrochloric acid of mass volume ratio 15 part 37%, and shake well, in the pure water of then slowly impouring mass volume ratio 1000 parts, stir simultaneously, obtain white flocculent polymer, filter with G3 funnel, pure water is to neutral, vacuum drying, pulverize, make wall material for subsequent use,
(2) get the hydroxypropyl methylcellulose of raw material components 10%, first use mass volume ratio 250 parts of pure water heating for dissolving, then add mass volume ratio 250 part of 95% ethanol, stir and make Gonak;
(3) get 860 ~ 900 parts, folic acid, dolomol 40 ~ 60 parts, after the Gonak prepared mixes, cross 1.25 millimeters of standard screens, then make the particle of 0.6 ~ 1.25 mm in size with granulator, make core for subsequent use with (2);
(4) particle (3) prepared drops in seed-coating machine, be preheated to 35 ~ 40 DEG C, and air inducing makes it to be suspended in dressing indoor, continue preheating seed-coating machine to 40 ~ 45 DEG C, adjustable spraying pressure is at 0.3MPa, the wall material (1) prepared is dissolved in carrene and ethanol is in 300 parts of solution of 1:1, sprays into seed-coating machine dressing indoor and carries out coating to core, make milk cow rumen bypass folic acid additive.
The using method of milk cow rumen bypass folic acid additive of the present invention is: thrown something and fed by the amount of every cow head 50 ~ 60mg/d by milk cow rumen bypass folic acid additive of the present invention.
the result of use test of milk cow rumen bypass folic acid additive of the present invention
1 test method
Four process are established in 1.1 experimental design tests, respectively: control group, the present invention I group and the present invention II group; Control group fed Basic drawing (45 parts of mixed concentrates+55 parts of maize straws); The present invention I group and the present invention II group add milk cow rumen bypass folic acid additive 50mg/d and 60mg/d respectively in control group fed Basic drawing.
Be prepared from according to preparation method of the present invention.
10 days feeding experiment preliminary trial periods, just trying 60 days phases.
1.2 experimental animals select 27 the first-borns time, 50 days postpartum, the output of milk, healthy cow that body weight is consistent or close with physiological status, adopt RANDOMIZED BLOCK DESIGN, milk cow is divided into 3 groups at random, often organize 9 oxen.
1.3 test dairy cow diet and management thereof
The daily ration of whole experimental period is made up of corn silage and mixed concentrate.Carry out Ration Compound according to Chinese raising dairy cattle standard (2000), mixed concentrate composition and trophic level composition are in table 1.Test ox concentrates on same cowshed, same feeding and management condition, and special messenger is responsible for.By feed mode thick after first essence, feed every day three times (7:00,15:00,22:00).After lower groove, sports ground is freely movable, ensures clean drinking-water, keeps colony house sanitation and hygiene.
1.4 index and approachs measured
1.4.1 during the collection of Feed Sample and determination test, all feed is sampled respectively, and in Agricultural University Of Shanxi's Animal nutrition laboratory, empirically room conventional method measures following items: dry (DM), crude protein (CP), crude fat (EE), coarse ash (CA), NFE (NFE).Acid detergent fiber (ADF) and neutral detergent fiber (NDF) VanSoest method measure.Its medium-height grass sample is got 200g/ time, and every 10d gets once, and sampling mixing (getting once before test) in continuous two days, fine fodder is with careless sample.
1.4.2 milk performance related index
The output of milk: precise respectively test ox morning, the noon, evening three amounts of milking, calculate daily yielding.
Milk composition: the every 10d of duration of test gathers milk sample in continuous two days, divide morning, noon with glass tube with a scale, get milk sample on the same day (getting a milk sample before test) for three times in proportion evening, milk sample amount is 60 ~ 70ml/ time head about, adds 6mg potassium bichromate anticorrosion.At Agricultural University Of Shanxi's Animal nutrition experimental determination milk composition, Denmark is adopted to produce MK-104 type infrared ray dairy products analysis-e/or determining butter oil rate, lactoprotein rate.
1.5 data processing
The One-way-Anova of market demand SPSS10.0 statistical analysis software carries out variance analysis and LSD Multiple range test.Result of the test represents with average ± standard error.
2 experimental results
2.1 milk cow rumen bypass folic acid additives are on the impact of milk production of cow
From table 2, the present invention II group experimental period average milk production be significantly higher than control group (
p<0.05), though the trend that the present invention I group experimental period average milk production is improved compared with control group, not remarkable with contrast difference.The present invention I group and II group of output of milk improve 1.16kg/d and 2.19kg/d before comparatively testing respectively.
2.2 milk cow rumen bypass folic acid additives are on the impact of holstein cow milk composition
From table 3, the present invention I group and the present invention II group experimental period A.milkfat percentage comparatively control group significantly improve (
p<0.05), improve 3.61% and 8.30% respectively before comparatively testing.From table 4, invent I group and the present invention II group experimental period average protein ratio comparatively control group significantly improve (
p<0.05), improve 4.11% and 5.77% respectively before comparatively testing.
Beneficial effect of the present invention
Milk cow rumen bypass folic acid additive of the present invention can promote feed digestion and improve the output of milk and milk-quality.Test shows, add 50 ~ 60mg/d milk cow rumen bypass folic acid additive by every cow head, milk production of cow improves 1.16 ~ 2.19kg/d, and butterfat percnetage improves 3.61% ~ 8.30%, and lactoprotein rate improves 4.11% ~ 5.77%.
embodiment 1
Preparation milk cow rumen bypass folic acid additive.
Raw material form: folic acid 900g, hydroxypropyl methylcellulose 30g, trimellitic anhydride 15g, anhydrous sodium acetate 15g, dolomol 40g, 37% hydrochloric acid 15ml, glacial acetic acid 150ml.
Below preparation process:
(1) glacial acetic acid 150ml and 27g hydroxypropyl methylcellulose are added be furnished with in the container of reflux condensate device, control temperature 90 DEG C, it is made to dissolve completely, add trimellitic anhydride 15g again, anhydrous sodium acetate 15g, insulation reaction 10 hours, by pure water 50ml cessation reaction, and in reactant liquor, add the hydrochloric acid 15ml of 37%, and shake well, in the pure water of then slowly impouring 1000ml, stir simultaneously, obtain white flocculent polymer, filter with G3 funnel, pure water is to neutral, vacuum drying, pulverize, it is for subsequent use that synthesis HPMCT makes wall material,
(2) get 3g hydroxypropyl methylcellulose, first use 250ml pure water heating for dissolving, then add 250ml95% ethanol, stir and make Gonak;
(3) get folic acid 900g, dolomol 40g, after the Gonak prepared mixes, cross 1.25 millimeters of standard screens, then make the particle of 0.6 ~ 1.25 mm in size with granulator, make core for subsequent use with (2);
(4) particle (3) prepared drops in seed-coating machine, be preheated to 35 ~ 40 DEG C, and air inducing makes it to be suspended in dressing indoor, continue preheating seed-coating machine to 40 ~ 45 DEG C, adjustable spraying pressure is at 0.3MPa, the wall material (2) prepared is dissolved in carrene and ethanol is in the 300ml solution of 1:1, sprays into seed-coating machine dressing indoor and carries out coating to core, make milk cow rumen bypass folic acid additive.
The using method of milk cow rumen bypass folic acid additive is: thrown something and fed by the amount of every cow head 50 ~ 60mg/d by milk cow rumen bypass folic acid additive of the present invention.
embodiment 2
Preparation milk cow rumen bypass folic acid additive.
Raw material form: folic acid 885g, hydroxypropyl methylcellulose 40g, trimellitic anhydride 15g, anhydrous sodium acetate 15g, dolomol 55g, 37% hydrochloric acid 15ml, glacial acetic acid 150ml.
Preparation process and with using method with embodiment 1.
embodiment 3
Preparation milk cow rumen bypass folic acid additive.
Raw material form: folic acid 860g, hydroxypropyl methylcellulose 50g, trimellitic anhydride 15g, anhydrous sodium acetate 15g, dolomol 60g, 37% hydrochloric acid 15ml, glacial acetic acid 150ml.
Preparation process and with using method with embodiment 1.
embodiment 4
Preparation milk cow rumen bypass folic acid additive.
Raw material form: folic acid 880g, hydroxypropyl methylcellulose 45g, trimellitic anhydride 15g, anhydrous sodium acetate 15g, dolomol 50g, 37% hydrochloric acid 15ml, glacial acetic acid 150ml.
Preparation process and with using method with embodiment 1.
embodiment 5
Preparation milk cow rumen bypass folic acid additive.
Raw material form: folic acid 870g, hydroxypropyl methylcellulose 35g, trimellitic anhydride 15g, anhydrous sodium acetate 15g, dolomol 45g, 37% hydrochloric acid 15ml, glacial acetic acid 150ml.
Preparation process and with using method with embodiment 1.
Claims (3)
1. milk cow rumen bypass folic acid additive, it is characterized in that, described additive is formulated by the raw material of following mass parts: folic acid 860 ~ 900, hydroxypropyl methylcellulose 30 ~ 50, trimellitic anhydride 15, anhydrous sodium acetate 15, the hydrochloric acid 15 of dolomol 40 ~ 60,37%, glacial acetic acid 150; Described hydroxypropyl methylcellulose, trimellitic anhydride, dolomol will meet food grade additives standard; Described folic acid meets feed grade additive standard; Described glacial acetic acid, anhydrous sodium acetate and concentrated hydrochloric acid meet analyzes pure and mild chemically pure reagent standard;
The preparation method of milk cow rumen bypass folic acid additive, comprises the steps:
(1) synthesize HPMCT the hydroxypropyl methylcellulose of 150 parts, glacial acetic acid and raw material components 90% is added to be furnished with in the container of reflux condensate device, control temperature 90 DEG C, it is made to dissolve completely, add trimellitic anhydride 15 parts again, anhydrous sodium acetate 15 parts, insulation reaction 10 hours, by mass volume ratio 50 parts of pure water cessation reactions, and in reactant liquor, add the hydrochloric acid of mass volume ratio 15 part 37%, and shake well, in the pure water of then slowly impouring mass volume ratio 1000 parts, stir simultaneously, obtain white flocculent polymer, filter with G3 funnel, pure water is to neutral, vacuum drying, pulverize, make wall material for subsequent use,
(2) get the hydroxypropyl methylcellulose of raw material components 10%, first use mass volume ratio 250 parts of pure water heating for dissolving, then add mass volume ratio 250 part of 95% ethanol, stir and make Gonak;
(3) get 860 ~ 900 parts, folic acid, dolomol 40 ~ 60 parts, after the Gonak prepared mixes, cross 1.25 millimeters of standard screens, then make the particle of 0.6 ~ 1.25 mm in size with granulator, make core for subsequent use with (2);
(4) particle (3) prepared drops in seed-coating machine, be preheated to 35 ~ 40 DEG C, and air inducing makes it to be suspended in dressing indoor, continue preheating seed-coating machine to 40 ~ 45 DEG C, adjustable spraying pressure is at 0.3MPa, the wall material (1) prepared is dissolved in carrene and ethanol is in 300 parts of solution of 1:1, sprays into seed-coating machine dressing indoor and carries out coating to core, make milk cow rumen bypass folic acid additive.
2. milk cow rumen bypass folic acid additive according to claim 1, it is characterized in that, described additive is formulated by the raw material of following mass parts: folic acid 900, hydroxypropyl methylcellulose 30, trimellitic anhydride 15, anhydrous sodium acetate 15, the hydrochloric acid 15 of dolomol 40,37%, glacial acetic acid 150.
3. the using method of milk cow rumen bypass folic acid additive is: thrown something and fed by the amount of every cow head 50 ~ 60mg/d by milk cow rumen bypass folic acid additive.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3493685A1 (en) * | 2016-08-02 | 2019-06-12 | Zinpro Corporation | Folic acid rumen by-pass method and composition |
| CN110692821A (en) * | 2019-10-21 | 2020-01-17 | 安徽农业大学 | Feed additive for improving rumen fermentation efficiency of cattle |
| CN110771742A (en) * | 2019-10-21 | 2020-02-11 | 安徽农业大学 | Feed additive for reducing methane emission of rumen of cattle and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104824476A (en) * | 2015-05-29 | 2015-08-12 | 浙江农林大学 | Rumen bypass protection folic acid, cow beverage containing rumen bypass protection folic acid and application of cow beverage |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104824476A (en) * | 2015-05-29 | 2015-08-12 | 浙江农林大学 | Rumen bypass protection folic acid, cow beverage containing rumen bypass protection folic acid and application of cow beverage |
Non-Patent Citations (1)
| Title |
|---|
| 石万聪等: "《增塑剂实用手册》", 31 January 2009, 化学工业出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3493685A1 (en) * | 2016-08-02 | 2019-06-12 | Zinpro Corporation | Folic acid rumen by-pass method and composition |
| CN110692821A (en) * | 2019-10-21 | 2020-01-17 | 安徽农业大学 | Feed additive for improving rumen fermentation efficiency of cattle |
| CN110771742A (en) * | 2019-10-21 | 2020-02-11 | 安徽农业大学 | Feed additive for reducing methane emission of rumen of cattle and preparation method thereof |
| CN110692821B (en) * | 2019-10-21 | 2022-12-20 | 安徽农业大学 | Feed additive for improving rumen fermentation efficiency of cattle |
| CN110771742B (en) * | 2019-10-21 | 2022-12-20 | 安徽农业大学 | Feed additive for reducing methane emission of rumen of cattle and preparation method thereof |
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