CN105165811A - Emulsion in water with effective ingredient dissolved in polar solvent and preparation method thereof - Google Patents
Emulsion in water with effective ingredient dissolved in polar solvent and preparation method thereof Download PDFInfo
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- CN105165811A CN105165811A CN201510494088.1A CN201510494088A CN105165811A CN 105165811 A CN105165811 A CN 105165811A CN 201510494088 A CN201510494088 A CN 201510494088A CN 105165811 A CN105165811 A CN 105165811A
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Abstract
The invention relates to an emulsion in water with an effective ingredient dissolved in a polar solvent and a preparation method thereof; the emulsion in water includes the following components by weight: 0.1-50% of the pesticide effective ingredient, 0.1-30% of the polar solvent, 0.1-20% of a cosolvent, 0.1-10% of a surfactant, 1-5% of a stabilizing agent, 1-5% of an antifreezing agent, and the balance water. The emulsion in water has the advantages of stable dosage form performance, simple production process flow, and low investment and equipment costs; and emulsion in water products with stable quality, good drug efficacy and storage resistance can be obtained by adopting a reasonable processing technology.
Description
Technical field
The present invention relates to a class and be dissolved in aqueous emulsion of polar solvent active ingredient and preparation method thereof, belong to agrochemical field.
Background technology
Pesticide emulsion in water (emulsioninwater, EW), that water-fast former medicine is dispersed in the metastable suspension system of the one formed in water by adding suitable auxiliary agent, water is the aqueous suspension agent of continuous phase, compared with missible oil, manufacture, safety in utilization, cost, transport, packaging there is more advantage; Do not contain or only have organic solvent inflammable and poisonous on a small quantity, having higher lightning, without the danger of Fire explosion; With the water of cheapness for matrix, the consumption of emulsifier is suitable with missible oil, and cost also has reduction in various degree, also can not show a candle to missible oil harshness to the requirement of packing container, can from price with missible oil competition; During sprinkling, mist droplet particle size is larger than missible oil, can reduce the volatilization of pesticide active ingredient and the pollution to environment.
Although pesticide emulsion in water has many advantages, but it prepares difficulty also increases accordingly, require that active ingredient is preferably the solid of liquid or low melting point, have low water-soluble to avoid crystallization, solid active ingredient need be dissolved in the solvent of low aqueous solubility simultaneously, and the former medicine of some good drug efficacy is only dissolved in polar solvent, be insoluble in non-polar solven, need to make aqueous emulsion, this more increases difficulty prepared by aqueous emulsion
A class of the present invention is dissolved in the obtained formulation stable performance of aqueous emulsion of polar solvent active ingredient and preparation method thereof, easily degrades, and the technological process of production is simple, investment and cost of equipment low; The present invention adopts rational processing technology can obtain the aqueous emulsion product of steady quality, good drug efficacy, for shelf-stable.
Summary of the invention
The object of this invention is to provide a class and be dissolved in aqueous emulsion of polar solvent active ingredient and preparation method thereof, its summary of the invention is as follows:
One class is dissolved in the aqueous emulsion of polar solvent active ingredient, comprises the component of following weight ratio: pesticide active ingredient 0.1-50%, polar solvent 0.1-30%, cosolvent 0.1-20%, surfactant 0.1-10%, stabilizing agent 1-5%, antifreezing agent 1-5%, water surplus.
Described pesticide active ingredient is the one in Avermectin, flucarbazone, MTI-446.
Described polar solvent is one or more in cyclohexanone, butyl acetate, sec-butyl acetate, ethanol, dimethylacetylamide, dimethyl sulfoxide (DMSO).
Described cosolvent is tributyl phosphate.
Described surfactant is one or more in OPEO, alkaryl phenol polyethenoxy ether phosphate, castor oil polyoxyethylene ether, alkylphenol-polyethenoxy phosphate, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, fatty alcohol-polyoxyethylene ether, disecoctylmaleate sodium sulfonate.
Described stabilizing agent is the mixing of one or more in peanut oil, epoxidized soybean oil, epoxidized linseed oil, soybean oil.
Described antifreezing agent is the mixing of one or more in urea, propane diols, glycerine, ethylene glycol.
Described water is deionized water.
One class is dissolved in the preparation method of the aqueous emulsion of polar solvent active ingredient: after being dissolved by agricultural chemicals with polar solvent, add cosolvent, surfactant, stabilizing agent and antifreezing agent, after mixing, add water, then high speed shear, obtains described aqueous emulsion.
A class of the present invention is dissolved in the obtained formulation stable performance of aqueous emulsion of polar solvent active ingredient and preparation method thereof, easily degrades, and the technological process of production is simple, investment and cost of equipment low; The present invention adopts rational processing technology can obtain the aqueous emulsion product of steady quality, good drug efficacy, for shelf-stable.
Embodiment
In order to understand essence of the present invention better; below in conjunction with embodiment, content of the present invention is described in further detail; content mentioned in embodiment is not limitation of the invention; the following stated is only for explaining the present invention; for not departing from amendment that the present invention's spirit and principle make, replacement or improvement, all belong to the scope of protection of present invention.
Embodiment one
According to technical scheme of the present invention, the former medicine 3.16g of 95% Avermectin crystal, after dissolving, then adds 17g tributyl phosphate with 12g cyclohexanone, after stirring evenly, add surfactant alkylbenzenesulfonate and disecoctylmaleate sodium sulfonate 3g, stabilizing agent epoxidized soybean oil 2g, after the abundant mixed dissolution of ethylene glycol 3g, add deionized water 59.84g, clipper 7000 turns shears 10min, obtained 3% abamectin aqueous emulsion.
Embodiment two
According to technical scheme of the present invention, the former medicine 5.26g of 95% MTI-446, with 15g dimethylacetamide amine solvent, then add 15g tributyl phosphate, after shaking up, add surfactant alkylbenzenesulfonate and disecoctylmaleate sodium sulfonate 5g, after the abundant mixed dissolution of stabilizing agent epoxidized soybean oil 2g, ethylene glycol 3g, add deionized water 54.74g, clipper 7000 turns shears 10min, obtained 5% MTI-446 aqueous emulsion.
Embodiment three
According to technical scheme of the present invention, the former medicine 5.26g of 95% flucarbazone, after 15g dimethylacetamide amine solvent, then add 20g tributyl phosphate, after shaking up, add surfactant alkylbenzenesulfonate and disecoctylmaleate sodium sulfonate 4g, after the abundant mixed dissolution of stabilizing agent epoxidized soybean oil 2g, ethylene glycol 3g, add deionized water 50.74g, clipper 7000 turns shears 10min, obtained 5% flucarbazone aqueous emulsion.
Claims (9)
1. a class is dissolved in the aqueous emulsion of polar solvent active ingredient, comprises the component of following weight ratio: pesticide active ingredient 0.1-50%, polar solvent 0.1-30%, cosolvent 1-20%, surfactant 0.1-10%, stabilizing agent 1-5%, antifreezing agent 1-5%, water surplus.
2. a class according to claim 1 is dissolved in the aqueous emulsion of polar solvent active ingredient, it is characterized in that: described pesticide active ingredient is the one in Avermectin, flucarbazone, MTI-446.
3. a class according to claim 1 is dissolved in the aqueous emulsion of polar solvent active ingredient, it is characterized in that: described polar solvent be cyclohexanone, butyl acetate, sec-butyl acetate, ethanol, dimethylacetylamide, dimethyl sulfoxide (DMSO), in the mixing of one or more.
4. a class according to claim 1 is dissolved in the aqueous emulsion of polar solvent active ingredient, it is characterized in that: described cosolvent is tributyl phosphate.
5. a class according to claim 1 is dissolved in the aqueous emulsion of polar solvent active ingredient, it is characterized in that: described surfactant is the mixing of one or more in OPEO, alkaryl phenol polyethenoxy ether phosphate, castor oil polyoxyethylene ether, alkylphenol-polyethenoxy phosphate, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, fatty alcohol-polyoxyethylene ether, disecoctylmaleate sodium sulfonate.
6. a class according to claim 1 is dissolved in aqueous emulsion of polar solvent active ingredient and preparation method thereof, it is characterized in that: described stabilizing agent is the mixing of one or more in peanut oil, epoxidized soybean oil, epoxidized linseed oil, soybean oil.
7. a class according to claim 1 is dissolved in aqueous emulsion of polar solvent active ingredient and preparation method thereof, it is characterized in that: described antifreezing agent is the mixing of one or more in urea, propane diols, glycerine, ethylene glycol.
8. a class according to claim 1 is dissolved in aqueous emulsion of polar solvent active ingredient and preparation method thereof, it is characterized in that: described water is deionized water.
9. a class is dissolved in the preparation method of the aqueous emulsion of polar solvent active ingredient: after being dissolved by agricultural chemicals with polar solvent, add cosolvent, surfactant, stabilizing agent and antifreezing agent, after mixing, add water, then high speed shear, obtains described aqueous emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510494088.1A CN105165811A (en) | 2015-08-12 | 2015-08-12 | Emulsion in water with effective ingredient dissolved in polar solvent and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510494088.1A CN105165811A (en) | 2015-08-12 | 2015-08-12 | Emulsion in water with effective ingredient dissolved in polar solvent and preparation method thereof |
Publications (1)
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| CN105165811A true CN105165811A (en) | 2015-12-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201510494088.1A Pending CN105165811A (en) | 2015-08-12 | 2015-08-12 | Emulsion in water with effective ingredient dissolved in polar solvent and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113209012A (en) * | 2021-06-04 | 2021-08-06 | 湖南伟达科技有限公司 | Avermectin transdermal solution and preparation method thereof |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775026A (en) * | 2005-11-21 | 2006-05-24 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN1788563A (en) * | 2005-11-21 | 2006-06-21 | 河北威远生物化工股份有限公司 | Insecticide microemulsion containing methylamino avermectin |
| CN101002559A (en) * | 2006-01-17 | 2007-07-25 | 上海农乐生物制品股份有限公司 | Aqueous emulsion containing abamectin, and its preparing method |
| CN103210929A (en) * | 2013-03-24 | 2013-07-24 | 广东中迅农科股份有限公司 | Pymetrozine water emulsion and preparation method thereof |
| CN103518735A (en) * | 2013-10-08 | 2014-01-22 | 王玉梅 | Quizalofop-p-ethyl emulsion in water |
-
2015
- 2015-08-12 CN CN201510494088.1A patent/CN105165811A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1775026A (en) * | 2005-11-21 | 2006-05-24 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN1788563A (en) * | 2005-11-21 | 2006-06-21 | 河北威远生物化工股份有限公司 | Insecticide microemulsion containing methylamino avermectin |
| CN101002559A (en) * | 2006-01-17 | 2007-07-25 | 上海农乐生物制品股份有限公司 | Aqueous emulsion containing abamectin, and its preparing method |
| CN103210929A (en) * | 2013-03-24 | 2013-07-24 | 广东中迅农科股份有限公司 | Pymetrozine water emulsion and preparation method thereof |
| CN103518735A (en) * | 2013-10-08 | 2014-01-22 | 王玉梅 | Quizalofop-p-ethyl emulsion in water |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113209012A (en) * | 2021-06-04 | 2021-08-06 | 湖南伟达科技有限公司 | Avermectin transdermal solution and preparation method thereof |
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Application publication date: 20151223 |