CN105164143B - 用于将分子引入到乳糜微粒中的胆固醇体囊泡 - Google Patents

用于将分子引入到乳糜微粒中的胆固醇体囊泡 Download PDF

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CN105164143B
CN105164143B CN201480025264.0A CN201480025264A CN105164143B CN 105164143 B CN105164143 B CN 105164143B CN 201480025264 A CN201480025264 A CN 201480025264A CN 105164143 B CN105164143 B CN 105164143B
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acid
composition
cholesterol
cell
monoclonal antibody
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CN105164143A (zh
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杰罗米.J.申塔格
玛丽.P.麦克考特
劳伦斯.米尔尼基
朱莉.休格斯
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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    • A61K9/1275—Lipoproteins or protein-free species thereof, e.g. chylomicrons; Artificial high-density lipoproteins [HDL], low-density lipoproteins [LDL] or very-low-density lipoproteins [VLDL]; Precursors thereof
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CN201480025264.0A 2013-03-14 2014-03-14 用于将分子引入到乳糜微粒中的胆固醇体囊泡 Active CN105164143B (zh)

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US201361783003P 2013-03-14 2013-03-14
US61/783,003 2013-03-14
PCT/US2014/027761 WO2014152795A2 (en) 2013-03-14 2014-03-14 Cholestosome vesicles for incorporation of molecules into chylomicrons

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CN105164143B true CN105164143B (zh) 2019-02-19

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US (6) US9693968B2 (cg-RX-API-DMAC7.html)
EP (1) EP2970369B1 (cg-RX-API-DMAC7.html)
JP (2) JP2016513712A (cg-RX-API-DMAC7.html)
CN (1) CN105164143B (cg-RX-API-DMAC7.html)
AU (1) AU2014236559B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015022936A2 (cg-RX-API-DMAC7.html)
CA (1) CA2905108C (cg-RX-API-DMAC7.html)
IL (1) IL241501B (cg-RX-API-DMAC7.html)
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