CN105148740A - Cellulose acetate/chitosan blood dialysis membrane and preparation method thereof - Google Patents
Cellulose acetate/chitosan blood dialysis membrane and preparation method thereof Download PDFInfo
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- CN105148740A CN105148740A CN201510257153.9A CN201510257153A CN105148740A CN 105148740 A CN105148740 A CN 105148740A CN 201510257153 A CN201510257153 A CN 201510257153A CN 105148740 A CN105148740 A CN 105148740A
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Abstract
The invention discloses a cellulose acetate/chitosan blood dialysis membrane and a preparation method thereof, and relates to the field of biomaterials. The cellulose acetate/chitosan blood dialysis membrane is a hollow fiber film with hollow fiber diameter of 0.4-4 microns, aperture sizes of 2.2-4.8 microns and wall thickness of 40-80 microns. The dialysis membrane is prepared from 33-56 parts by mass of cellulose acetate, 12-18 parts by mass of chitosan, 5-10 parts by mass of phosphoric acid, 3-10 parts by mass of polyvinyl alcohol, 12-22 parts by mass of tetrahydrofuran and 8-16 parts by mass of dimethyl acetamide. The preparation method comprises 1, spinning liquid preparation and 2, electrostatic spinning. The cellulose acetate/chitosan blood dialysis membrane has good biocompatibility and good biofunctionability, has a high macromolecular protein retention rate and a high urea and water passing rate, and is an ideal dialysis membrane material.
Description
Technical field
The invention belongs to technical field of biological material, particularly the preparation method of a kind of cellulose acetate/shitosan hemodialysis membrane and this hemodialysis membrane.
Background technology
Hemodialysis membrane is the principle utilizing pellicle, by the solute gradient of film both sides, osmotic gradient and hydraulic pressure gradient, removes to reach the moisture that in toxin and body, retention is too much, simultaneously required in added body material, and maintains the object of electrolyte and acid-base balance.
Therefore, the requirement of following aspect should be possessed for Hemodialysis Membrane Material: (1) biocompatibility; (2) Biofunctional, namely possesses good dialysis performance; (3) as far as possible low host response, comprises allergy and Coagulation test; (4) spinnability.
Existing Hemodialysis Membrane Material is by two kinds: one is cellulose acetate membrane material; Another is synthetic material, comprises the materials such as polysulfones, polyacrylonitrile, polymethyl methacrylate and polyether sulfone.Cellulose acetate is a kind of porous film material, it is one of material being applied to hemodialysis membrane the earliest, transmitance for urea and water can meet the demands, but its densification is poor, when under high pressure using, can diminish because dialysis material leads membrane aperture, the percent of pass for blood small molecular material reduces, therefore, but also its use causes puzzlement.
Summary of the invention
The technical problem that the present invention solves: for above-mentioned deficiency, overcome the defect of prior art, the object of this invention is to provide a kind of cellulose acetate/shitosan hemodialysis membrane and preparation method thereof.
Technical scheme of the present invention: a kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 0.4-4 μm, and aperture is 2.2-4.8 μm, wall thickness 40-80 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 33-56 part, shitosan 12-18 part, phosphoric acid 5-10 part, polyvinyl alcohol 3-10 part, oxolane 12-22 part and dimethylacetylamide 8-16 part.
As preferably, described dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 40-50 part, shitosan 13-15 part, phosphoric acid 6-9 part, polyvinyl alcohol 5-9 part, oxolane 15-20 part and dimethylacetylamide 10-15 part.
As preferably, described dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 46 parts, shitosan 14 parts, phosphoric acid 7 parts, polyvinyl alcohol 6 parts, oxolane 16 parts and dimethylacetylamide 12 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 180-200r/min, spinning voltage 10-15kv, spinning speed 0.5-2ml/h, receiving range is 11-15cm.
As preferably, the voltage of step (2) electrostatic spinning is 12kv, spinning speed 2ml/h, and receiving range is 11cm.
Beneficial effect: cellulose acetate provided by the invention/shitosan hemodialysis membrane, be take cellulose acetate as material of main part, cellulose acetate is as the good porous film material of one, it has good percent of pass to urea and glassware for drinking water, but its densification is poor, under high pressure uses, its membrane aperture is for diminish gradually, moieties flux is caused to decline, especially under high pressure, blood platelet can be assembled on film, causes blood coagulation phenomenon, therefore, Dichlorodiphenyl Acetate cellulose fibre film is needed to improve.Shitosan, in serum, easy degraded absorbs, there is higher biological degradability, and for protein, there is higher adsorption capacity, therefore, bi-material is combined, by the synergy of other components, Biofunctional and the biocompatibility of dialysis membrane effectively may be provided, and for high molecular weight protein, there is higher rejection.
By hemodialysis membrane prepared by electrostatic spinning process, doughnut diameter is moderate, and dialysis membrane porosity is ideal, therefore, it is possible to better provide the performance of dialysis membrane.
Therefore, cellulose acetate provided by the invention/shitosan hemodialysis membrane has good biocompatibility and Biofunctional, have higher rejection for high molecular weight protein, the percent of pass for urea and water is higher, is a kind of ideal dialysis membrane material.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
Embodiment 1:
A kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.4 μm, and aperture is 3.5 μm, wall thickness 70 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 33 parts, shitosan 12 parts, phosphoric acid 5 parts, polyvinyl alcohol 3 parts, oxolane 12 parts and dimethylacetylamide 8 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 2ml/h, receiving range is 11cm.
As preferably, the voltage of step (2) electrostatic spinning is 12kv, spinning speed 2ml/h, and receiving range is 11cm.
Measure the cellulose acetate/shitosan hemodialysis membrane of preparation, its water ultrafiltration is 39.3mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.5%; Urea permeability 189P
m10
4cmmin
-1; Cobastab
12transmitance 87P
m10
4cmmin
-1.
Embodiment 2:
A kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.4 μm, and aperture is 3.5 μm, wall thickness 70 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 56 parts, shitosan 18 parts, phosphatase 11 0 part, polyvinyl alcohol 10 parts, oxolane 22 parts and dimethylacetylamide 16 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 2ml/h, receiving range is 11cm.
Measure the cellulose acetate/shitosan hemodialysis membrane of preparation, its water ultrafiltration is 39.6mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.6%; Urea permeability 192P
m10
4cmmin
-1; Cobastab
12transmitance 88P
m10
4cmmin
-1.
Embodiment 3:
A kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.4 μm, and aperture is 3.5 μm, wall thickness 70 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 40 parts, shitosan 13 parts, phosphoric acid 6 parts, polyvinyl alcohol 5 parts, oxolane 15 parts and dimethylacetylamide 10 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 2ml/h, receiving range is 11cm.
Measure the cellulose acetate/shitosan hemodialysis membrane of preparation, its water ultrafiltration is 39.3mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.5%; Urea permeability 192P
m10
4cmmin
-1; Cobastab
12transmitance 86P
m10
4cmmin
-1.
Embodiment 4:
A kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 2.4 μm, and aperture is 3.7 μm, wall thickness 60 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 50 parts, shitosan 15 parts, phosphatase 79 part, polyvinyl alcohol 9 parts, oxolane 20 parts and dimethylacetylamide 15 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 2ml/h, receiving range is 11cm.
Measure the cellulose acetate/shitosan hemodialysis membrane of preparation, its water ultrafiltration is 39.4mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.5%; Urea permeability 195P
m10
4cmmin
-1; Cobastab
12transmitance 89P
m10
4cmmin
-1.
Embodiment 5:
A kind of cellulose acetate/shitosan hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 2.4 μm, and aperture is 3.7 μm, wall thickness 60 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 46 parts, shitosan 14 parts, phosphoric acid 7 parts, polyvinyl alcohol 6 parts, oxolane 16 parts and dimethylacetylamide 12 parts.
A preparation method for cellulose acetate/shitosan hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 2ml/h, receiving range is 11cm.
Measure the cellulose acetate/shitosan hemodialysis membrane of preparation, its water ultrafiltration is 40.1mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.6%; Urea permeability 199P
m10
4cmmin
-1; Cobastab
12transmitance 93P
m10
4cmmin
-1.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (5)
1. cellulose acetate/shitosan hemodialysis membrane, is characterized in that: dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 0.4-4 μm, and aperture is 2.2-4.8 μm, wall thickness 40-80 μm;
Dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 33-56 part, shitosan 12-18 part, phosphoric acid 5-10 part, polyvinyl alcohol 3-10 part, oxolane 12-22 part and dimethylacetylamide 8-16 part.
2. cellulose acetate according to claim 1/shitosan hemodialysis membrane, is characterized in that: described dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 40-50 part, shitosan 13-15 part, phosphoric acid 6-9 part, polyvinyl alcohol 5-9 part, oxolane 15-20 part and dimethylacetylamide 10-15 part.
3. cellulose acetate according to claim 1/shitosan hemodialysis membrane, is characterized in that: described dialysis membrane is prepared from by each component of following mass fraction: cellulose acetate 46 parts, shitosan 14 parts, phosphoric acid 7 parts, polyvinyl alcohol 6 parts, oxolane 16 parts and dimethylacetylamide 12 parts.
4. a preparation method for cellulose acetate according to claim 1/shitosan hemodialysis membrane, it is characterized in that, preparation process is as follows:
(1) spinning solution preparation: cellulose acetate, shitosan, phosphoric acid and polyvinyl alcohol are joined in the mixed solution of oxolane and dimethylacetylamide, dissolve at 37 DEG C of heating water baths, sonic oscillation 5min, obtains spinning solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained cellulose acetate/shitosan hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 180-200r/min, spinning voltage 10-15kv, spinning speed 0.5-2ml/h, receiving range is 11-15cm.
5. the preparation method of cellulose acetate according to claim 4/shitosan hemodialysis membrane, is characterized in that: the voltage of step (2) electrostatic spinning is 12kv, spinning speed 2ml/h, and receiving range is 11cm.
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
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CN107551822A (en) * | 2017-09-05 | 2018-01-09 | 泉州市科茂利通智能科技有限公司 | A kind of compound hemodialysis membrane of polyacrylonitrile carboxymethyl chitosan and preparation method thereof |
CN110813106A (en) * | 2019-11-28 | 2020-02-21 | 吉林大学 | MOFs modified double-layer structure composite electrospun nanofiber membrane, preparation method and application thereof in blood purification |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101703893A (en) * | 2009-11-06 | 2010-05-12 | 江苏朗生生命科技有限公司 | Hollow fiber ultrafiltration composite membrane, preparation method and application thereof |
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- 2015-05-20 CN CN201510257153.9A patent/CN105148740A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN101703893A (en) * | 2009-11-06 | 2010-05-12 | 江苏朗生生命科技有限公司 | Hollow fiber ultrafiltration composite membrane, preparation method and application thereof |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107551822A (en) * | 2017-09-05 | 2018-01-09 | 泉州市科茂利通智能科技有限公司 | A kind of compound hemodialysis membrane of polyacrylonitrile carboxymethyl chitosan and preparation method thereof |
CN107551822B (en) * | 2017-09-05 | 2020-03-10 | 泉州市科茂利通智能科技有限公司 | Polyacrylonitrile-carboxymethyl chitosan composite hemodialysis membrane and preparation method thereof |
CN110813106A (en) * | 2019-11-28 | 2020-02-21 | 吉林大学 | MOFs modified double-layer structure composite electrospun nanofiber membrane, preparation method and application thereof in blood purification |
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