CN104894748A - Carbon fiber/polyester hemodialysis membrane and preparation method thereof - Google Patents
Carbon fiber/polyester hemodialysis membrane and preparation method thereof Download PDFInfo
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- CN104894748A CN104894748A CN201510257512.0A CN201510257512A CN104894748A CN 104894748 A CN104894748 A CN 104894748A CN 201510257512 A CN201510257512 A CN 201510257512A CN 104894748 A CN104894748 A CN 104894748A
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- polyester
- carbon fiber
- membrane
- hemodialysis membrane
- spinning
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Abstract
The invention discloses a carbon fiber/polyester hemodialysis membrane and a preparation method thereof, and relates to the field of biological materials. The hemodialysis membrane is a hollow fiber membrane, the diameter of a hollow fiber is 0.5-5 micrometers, the bore diameter of the hollow fiber is 1.4-4.3 micrometers, the wall thickness of the hollow fiber is 35-60 micrometers, the hemodialysis membrane is prepared from components including, by weight, 26-38 parts of polyester, 5-12 parts of carbon fibers, 8-18 parts of acetic acid, 10-17 parts of tetrahydrofuran, 2-5 parts of catalysts and 25-42 parts of solvents. The preparation method of the carbon fiber/polyester hemodialysis membrane includes the preparation steps: (1) preparing spinning solution; (2) performing electrostatic spinning. The carbon fiber/polyester hemodialysis membrane is prepared by an electrostatic spinning process, the diameter of the hollow fiber and the bore diameter of the fiber membrane are ideal, the wall thickness is proper, the hemodialysis membrane has fine biological compatibility, allergy and coagulation are greatly reduced, and the hemodialysis membrane is ideal.
Description
Technical field
The invention belongs to technical field of biological material, particularly the preparation method of a kind of carbon fiber/polyester hemodialysis membrane and this hemodialysis membrane.
Background technology
Hemodialysis membrane is the principle utilizing pellicle, by the solute gradient of film both sides, osmotic gradient and hydraulic pressure gradient, removes to reach the moisture that in toxin and body, retention is too much, simultaneously required in added body material, and maintains the object of electrolyte and acid-base balance.
Polyester fiber is one of conventional fiber in haemodialysis field, has low, the excellent crease resistance of moisture content, elasticity and DIMENSIONAL STABILITY, and rub resistance, not mouldly not eat into, there is good chemical reagent-resistant performance, energy weak acid resistant and weak base, but there is the feature of poor air permeability.
The chemical property of carbon fiber and carbon are known each other, and its decapacitation is inertia to general alkalescence outside being oxidized by strong oxidizer, it is existing ideal packing material, and carbon fiber can reduce allergy or blood coagulation phenomenon that dialysis membrane material causes, therefore, is also a kind of desirable dialysis membrane material.
Summary of the invention
The technical problem that the present invention solves: for above-mentioned deficiency, overcome the defect of prior art, the object of this invention is to provide a kind of carbon fiber/polyester hemodialysis membrane and preparation method thereof.
Technical scheme of the present invention: a kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 0.5-5 μm, and aperture is 1.4-4.3 μm, wall thickness 35-60 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 26-38 part, carbon fiber 5-12 part, acetic acid 8-18 part, oxolane 10-17 part, catalyst 2-5 part and solvent 25-42 part.
As preferably, described polyester is the one of polybutylene terephthalate or polyarylate.
As preferably, described catalyst is trimethylamine.
As preferably, described solvent is dimethylacetylamide and acetone.
As preferably, the mass ratio of described dimethylacetylamide and acetone is 1-2:3.
A preparation method for carbon fiber/polyester hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 150-200r/min, spinning voltage 9-16kv, spinning speed 0.5-2ml/h, receiving range is 11-15cm.
As preferably, the voltage of step (2) electrostatic spinning is 11kv, spinning speed 1ml/h, and receiving range is 12cm.
Beneficial effect: carbon fiber provided by the invention/polyester hemodialysis membrane, it is the compound bio membrane material of polyester and carbon fiber, the elasticity utilizing polyester fiber excellent and stability, in conjunction with the physical characteristic that carbon fiber is excellent, can effectively improve retaining and suction-operated septicemia element, there is provided biocompatibility, the allergy that reduction dialysis membrane material causes or blood coagulation phenomenon are a kind of ideal hemodialysis membranes.
By hemodialysis membrane prepared by electrostatic spinning process, doughnut diameter and tunica fibrosa aperture all ideal, wall thickness is moderate, and after tunica fibrosa is shaping, withstand voltage weatherability is all ideal.
Therefore, carbon fiber provided by the invention/polyester hemodialysis membrane has good biocompatibility, fabulous reduces allergic phenomena and blood coagulation phenomenon, is a kind of ideal dialysis membrane material.
Detailed description of the invention
In order to understand the present invention further, below in conjunction with embodiment, the preferred embodiment of the invention is described, but should be appreciated that these describe just for further illustrating the features and advantages of the present invention, instead of limiting to the claimed invention.
Embodiment 1:
A kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.5 μm, and aperture is 2.5 μm, wall thickness 45 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 26 parts, 5 parts, carbon fiber, acetic acid 8 parts, oxolane 10 parts, catalyst trimethylamine 2 parts, dimethylacetylamide 15 parts and 10 parts, acetone.
A preparation method for carbon fiber/polyester hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 180r/min, spinning voltage 10kv, spinning speed 1ml/h, receiving range is 12cm.
Measure the carbon fiber/polyester hemodialysis membrane of preparation, its water ultrafiltration is 38.3mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.5%; Urea permeability 187 P
m10
4cmmin
-1; Cobastab
12transmitance 78 P
m10
4cmmin
-1.
Embodiment 2:
A kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.5 μm, and aperture is 2.5 μm, wall thickness 45 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 38 parts, 12 parts, carbon fiber, acetic acid 18 parts, oxolane 17 parts, catalyst trimethylamine 5 parts, dimethylacetylamide 21 parts and 14 parts, acetone.
A preparation method for carbon fiber/polyester hemodialysis membrane, it is characterized in that, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 180r/min, spinning voltage 11kv, spinning speed 1ml/h, receiving range is 12cm.
Measure the carbon fiber/polyester hemodialysis membrane of preparation, its water ultrafiltration is 37.8mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.4%; Urea permeability 182 P
m10
4cmmin
-1; Cobastab
12transmitance 82 P
m10
4cmmin
-1.
Embodiment 3:
A kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 1.5 μm, and aperture is 2.5 μm, wall thickness 45 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 28 parts, 7 parts, carbon fiber, acetic acid 12 parts, oxolane 11 parts, catalyst trimethylamine 3 parts, dimethylacetylamide 18 parts and 10 parts, acetone.
A preparation method for carbon fiber/polyester hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 10kv, spinning speed 1ml/h, receiving range is 12cm.
Measure the carbon fiber/polyester hemodialysis membrane of preparation, its water ultrafiltration is 37.4mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.3%; Urea permeability 176 P
m10
4cmmin
-1; Cobastab
12transmitance 84 P
m10
4cmmin
-1.
Embodiment 4:
A kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 2 μm, and aperture is 3.2 μm, wall thickness 50 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 35 parts, 11 parts, carbon fiber, acetic acid 15 parts, oxolane 15 parts, catalyst trimethylamine 4 parts, dimethylacetylamide 24 parts and 12 parts, acetone.
A preparation method for carbon fiber/polyester hemodialysis membrane, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 12kv, spinning speed 1ml/h, receiving range is 12cm.
Measure the carbon fiber/polyester hemodialysis membrane of preparation, its water ultrafiltration is 38.5mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.5%; Urea permeability 177 P
m10
4cmmin
-1; Cobastab
12transmitance 87 P
m10
4cmmin
-1.
Embodiment 5:
A kind of carbon fiber/polyester hemodialysis membrane, dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 2.5 μm, and aperture is 2.8 μm, wall thickness 42 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 33 parts, 9 parts, carbon fiber, acetic acid 12 parts, oxolane 13 parts, catalyst trimethylamine 4 parts, dimethylacetylamide 30 parts and 10 parts, acetone.
A preparation method for carbon fiber/polyester hemodialysis membrane, it is characterized in that, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 200r/min, spinning voltage 11kv, spinning speed 1ml/h, receiving range is 12cm.
Measure the carbon fiber/polyester hemodialysis membrane of preparation, its water ultrafiltration is 37.7mLm
-2h
-1mmHg
-1; Bovine albumin rejection 99.4%; Urea permeability 182 P
m10
4cmmin
-1; Cobastab
12transmitance 84 P
m10
4cmmin
-1.
To the above-mentioned explanation of the disclosed embodiments, professional and technical personnel in the field are realized or uses the present invention.To be apparent for those skilled in the art to the multiple amendment of these embodiments, General Principle as defined herein can without departing from the spirit or scope of the present invention, realize in other embodiments.Therefore, the present invention can not be restricted to these embodiments shown in this article, but will meet the widest scope consistent with principle disclosed herein and features of novelty.
Claims (7)
1. carbon fiber/polyester hemodialysis membrane, is characterized in that: dialysis membrane is hollow-fibre membrane, and the diameter of doughnut is 0.5-5 μm, and aperture is 1.4-4.3 μm, wall thickness 35-60 μm;
Dialysis membrane is prepared from by each component of following mass fraction: polyester 26-38 part, carbon fiber 5-12 part, acetic acid 8-18 part, oxolane 10-17 part, catalyst 2-5 part and solvent 25-42 part.
2. carbon fiber according to claim 1/polyester hemodialysis membrane, is characterized in that: described polyester is the one of polybutylene terephthalate or polyarylate.
3. carbon fiber according to claim 1/polyester hemodialysis membrane, is characterized in that: described catalyst is trimethylamine.
4. carbon fiber according to claim 1/polyester hemodialysis membrane, is characterized in that: described solvent is dimethylacetylamide and acetone.
5. carbon fiber according to claim 4/polyester hemodialysis membrane, is characterized in that: the mass ratio of described dimethylacetylamide and acetone is 1-2:3.
6. a preparation method for carbon fiber according to claim 1/polyester hemodialysis membrane, it is characterized in that, preparation process is as follows:
(1) spinning solution preparation: be dissolved in solvent by polyester, carbon fiber, acetic acid and oxolane, dissolves at 37 DEG C of heating water baths, after solution clarification, catalyst ultrasonic disperse is obtained spinning solution in solution;
(2) electrostatic spinning: spinning solution is carried out electrostatic spinning, obtained carbon fiber/polyester hemodialysis membrane;
Wherein, electrostatic spinning process intermediate roll rotating speed 150-200r/min, spinning voltage 9-16kv, spinning speed 0.5-2ml/h, receiving range is 11-15cm.
7. the preparation method of carbon fiber according to claim 6/polyester hemodialysis membrane, is characterized in that: the voltage of step (2) electrostatic spinning is 11kv, spinning speed 1ml/h, and receiving range is 12cm.
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|---|---|---|---|
| CN201510257512.0A CN104894748A (en) | 2015-05-20 | 2015-05-20 | Carbon fiber/polyester hemodialysis membrane and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105970719A (en) * | 2016-05-26 | 2016-09-28 | 福建希源纸业有限公司 | Medical dialyzing paper |
| CN106592109A (en) * | 2016-12-23 | 2017-04-26 | 基努里(天津)生物科技有限公司 | High-molecular electrostatic spinning film and preparation method |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6185955A (en) * | 1984-10-02 | 1986-05-01 | 旭メデイカル株式会社 | Hollow yarn membrane for blood dialysis |
| CN1226197A (en) * | 1996-05-28 | 1999-08-18 | 出光石油化学株式会社 | Method and apparatus for producing hollow molded article |
| CN1799649A (en) * | 2005-12-09 | 2006-07-12 | 清华大学 | Blood compatible biological material and preparation method thereof |
| CN103088442A (en) * | 2013-01-23 | 2013-05-08 | 上海交通大学 | Preparation method of hollow fiber in coaxial electrostatic spinning |
| CN104368246A (en) * | 2014-11-10 | 2015-02-25 | 苏州蔻美新材料有限公司 | Polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane and preparation method thereof |
| CN104437127A (en) * | 2014-11-10 | 2015-03-25 | 苏州蔻美新材料有限公司 | Anti-coagulant polyester hemodialysis membrane and preparation method thereof |
-
2015
- 2015-05-20 CN CN201510257512.0A patent/CN104894748A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6185955A (en) * | 1984-10-02 | 1986-05-01 | 旭メデイカル株式会社 | Hollow yarn membrane for blood dialysis |
| CN1226197A (en) * | 1996-05-28 | 1999-08-18 | 出光石油化学株式会社 | Method and apparatus for producing hollow molded article |
| CN1799649A (en) * | 2005-12-09 | 2006-07-12 | 清华大学 | Blood compatible biological material and preparation method thereof |
| CN103088442A (en) * | 2013-01-23 | 2013-05-08 | 上海交通大学 | Preparation method of hollow fiber in coaxial electrostatic spinning |
| CN104368246A (en) * | 2014-11-10 | 2015-02-25 | 苏州蔻美新材料有限公司 | Polyacrylonitrile/cellulose acetate fiber composite hemodialysis membrane and preparation method thereof |
| CN104437127A (en) * | 2014-11-10 | 2015-03-25 | 苏州蔻美新材料有限公司 | Anti-coagulant polyester hemodialysis membrane and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105970719A (en) * | 2016-05-26 | 2016-09-28 | 福建希源纸业有限公司 | Medical dialyzing paper |
| CN106592109A (en) * | 2016-12-23 | 2017-04-26 | 基努里(天津)生物科技有限公司 | High-molecular electrostatic spinning film and preparation method |
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Application publication date: 20150909 |
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