CN105147896A - Compound bassia dasyphylla external medicament clearing fire and removing toxicity and preparing method thereof - Google Patents
Compound bassia dasyphylla external medicament clearing fire and removing toxicity and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a compound bassia dasyphylla external medicament clearing fire and removing toxicity and a preparing method thereof. The medicament is mainly used for treating sycosis and is remarkable in treatment effect. The external medicament is prepared from bassia dasyphylla, kalanchoe spathulata, musa basjoo, iris dichotoma pall, baikal betony rhizome, cymbium melo, quercus fabri hance, codonacanthus pauciflorus, rubus wilsonii duthie, lambert raspberry leaves, barnacle, eurya distichophylla hemsl, East-Asia low meadowrue, zehneria mysorensis arn, pronephrium triphyllum, alclometasone, nadifloxacin, carbopol, triethanolamine, methylparaben, antioxidants and intensyfikator smaku. The compound bassia dasyphylla external medicament clearing fire and removing toxicity has effects of clearing the fire, removing the toxicity, dispelling wind, eliminating dampness, activating and cooling blood, relieving pain and eliminating inflammation, and achieves the purpose of treating both manifestation and root causes of disease; moreover, effective ingredients of traditional Chinese medicine are prepared in a nanometer level mode, the medicine absorption rate is effectively increased, and the treatment effect is remarkable; the medicament is an external application, a certain amount of intensyfikator smaku is added, medicine odor is improved, and use is convenient.
Description
Technical field
The present invention relates to medicine and pharmacology technical field, compound recipe Herba Bassiae Dasyphyllae topical agent specifically relating to a kind of Qinghuo Jiedu and preparation method thereof.
Background technology
Tinea barbae is by bacterial suppurative folliculitis and perifolliculitis, is usually confined to beard district.Primary disease pathogen is mainly staphylococcus aureus, also can be other antibacterials once in a while.Shave, caused skin injury of having a shave, seborrhea, gastrointestinal dysfunction, can become the inducement of primary disease, and tired and anxious state of mind often makes primary disease recur.From the beginning of being small pieces redness, pityriasis rubra pimple or pustule, central authorities have hair to pass, and hair loosens can be transferred to, and exposes red rotten to the corn face after bleb is broken, and can mutually merge in flakes between pustule, dirty yellow crust is tied in drying, can leave over cicatrix more.Disappear in small number of patients skin lesion center, extending therearound, infiltrates obviously, and follicular orifice suppurates, and stays atrophic scar, hair follicle can be made to destroy after healing, and hair lacks as, title lupoid sycosis.
At present, the medicine of this disease of western medical treatment mainly contains whole body application antibiotic or superficial X-radiation, but eventually cures the symptoms, not the disease, and therefore also needs to use Chinese medicine to nurse one's health.Therefore, the object of the invention is to provide a kind of medicine for the treatment of tinea barbae, fundamentally treats tinea barbae, does not recur more.
Summary of the invention
Technical problem compound recipe Herba Bassiae Dasyphyllae topical agent being to provide a kind of Qinghuo Jiedu that the present invention solves and preparation method thereof, this medicament is mainly used in treating tinea barbae, evident in efficacy.
Technical scheme of the present invention is:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprising: Herba Bassiae Dasyphyllae 30 ~ 60 parts, Herba kalanchoes spathulatae 15 ~ 30 parts, 12 ~ 25 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 10 ~ 20 parts, Rhizoma Stachydis 10 ~ 30 parts, Cymbium melo (sdander) 9 ~ 15 parts, Involucrum Querci fabri 9 ~ 15 parts, campanilla grass 8 ~ 20 parts, Radix rubi pungentis 6 ~ 9 parts, Rubus lambertianus Ser. 5 ~ 15 parts, barnacle 4 ~ 10 parts, mountain standing grain string 3 ~ 10 parts, Thalictrum thumbergii D C 2 ~ 8 parts, horse small melon 2 ~ 7 parts, three mark 2 ~ 5 parts, alclometasone malonate 0.5 ~ 1.5 part, nadifloxacin 0.3 ~ 1.0 part.
Further, the compound recipe Herba Bassiae Dasyphyllae topical agent of described a kind of Qinghuo Jiedu, by weight, comprising: Herba Bassiae Dasyphyllae 40 ~ 50 parts, Herba kalanchoes spathulatae 20 ~ 25 parts, 17 ~ 20 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 14 ~ 16 parts, Rhizoma Stachydis 15 ~ 25 parts, Cymbium melo (sdander) 10 ~ 14 parts, Involucrum Querci fabri 11 ~ 13 parts, campanilla grass 10 ~ 18 parts, Radix rubi pungentis 7 ~ 8 parts, Rubus lambertianus Ser. 8 ~ 12 parts, barnacle 5 ~ 9 parts, mountain standing grain string 5 ~ 8 parts, Thalictrum thumbergii D C 4 ~ 6 parts, horse small melon 4 ~ 5 parts, three mark 3 ~ 4 parts, alclometasone malonate 0.5 ~ 1.5 part, nadifloxacin 0.3 ~ 1.0 part.
Further, the compound recipe Herba Bassiae Dasyphyllae topical agent of described a kind of Qinghuo Jiedu, optimum ratio is: Herba Bassiae Dasyphyllae 45 parts, Herba kalanchoes spathulatae 22.5 parts, 18.5 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 15 parts, Rhizoma Stachydis 20 parts, Cymbium melo (sdander) 12 parts, Involucrum Querci fabri 12 parts, campanilla grass 14 parts, Radix rubi pungentis 7.5 parts, Rubus lambertianus Ser. 10 parts, barnacle 7 parts, mountain standing grain string 6.5 parts, Thalictrum thumbergii D C 5 parts, horse small melon 4.5 parts, three mark 3.5 parts, alclometasone malonate 1.0 parts, nadifloxacin 0.65 part.
Improve as one, in the compound recipe Herba Bassiae Dasyphyllae topical agent of described a kind of Qinghuo Jiedu, can add a kind of medical material, i.e. Eurya nitida for the patient that dampness in body is heavier, the addition of Eurya nitida is 10 ~ 30 parts, Eurya nitida bitter in the mouth, puckery, and property is put down; Medicine wind-dispelling and dehumidifying functions can be strengthened with Herba Bassiae Dasyphyllae etc. is shared.
Further, the compound recipe Herba Bassiae Dasyphyllae topical agent of described a kind of Qinghuo Jiedu, by weight, also comprise: carbomer 1.2 ~ 1.8 parts, triethanolamine 10 ~ 16 parts, methyl hydroxybenzoate 1.0 ~ 1.2 parts, antioxidant 0.2 ~ 0.5 part, fumet 0.02 ~ 0.05 part.Wherein, alclometasone malonate topical application has antiinflammatory, vasoconstriction and the effect such as antipruritic; Nadifloxacin is antimicrobial drug, has broad spectrum antibiotic activity to gram positive bacteria, gram-negative bacteria, anaerobe and fastbacteria etc.
Further, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.
Further, described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
A preparation method for the compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 8 ~ 10 times amount soak by water 3 times, each decocting time is 1 ~ 1.5 hour, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 24 ~ 30h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 6.0 ~ 7.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 100 ~ 500nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks, Eurya nitidas are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 35 ~ 40Mpa, extraction temperature 30 ~ 35 DEG C, separator pressure 20 ~ 24Mpa, separator temperature 50 ~ 58 DEG C, disengaging time 1.5 ~ 2.5 hours, carbon dioxide flow 30 ~ 36L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 0.98 ~ 1.12, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 200 ~ 300nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 60 ~ 80 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1 ~ 2h, sub-bottle packaging, to obtain final product.
The pharmacologically active of the present invention's used medical material is as follows:
Herba Bassiae Dasyphyllae: [nature and flavor] are sweet, light, are slightly cold.[function cures mainly] clearing heat and expelling damp.Cure mainly seborrheic dermatitis.
Herba kalanchoes spathulatae: [nature and flavor] are bitter; Sweet; Cold.[return through] lung; Liver; Kidney channel.[function cures mainly] refreshing and detoxicating.Control carbuncle pyogenic infections from tumour or sore, swelling pain of eying covetously, otitis media.
Musa basjoo Sieb. Et Zucc. head: [nature and flavor] are light, cool.[function cures mainly] heat-clearing and toxic substances removing, inducing diuresis to remove edema, removing heat from blood, pain relieving.For cold cough, headache, hypertension, stomachache, stomachache, hepatitis, dysentery, metrorrhagia, frequent fetal movement, urinary tract infection, edema; Otitis media is controlled in external, wound hemorrhage, carbuncle furuncle and phyma poison.
Flat cattail leaf fan: [nature and flavor] are bitter, cold.Slightly poisonous.[function cures mainly] promoting blood circulation and detumescence.Cure mainly laryngopharynx swelling and pain, tonsillitis, hepatitis, hepatomegaly, stomachache, mastitis.
Rhizoma Stachydis: [function cures mainly] be " detailed outline is picked up any lost article from the road " 1.: " control and injure, flutter wound, and control all rotten pain skin ulcer tinea, spit blood." 2. " Zhejiang natural resources of Chinese medicinal materials register ": " relieves inflammation or internal heat, suppressing the hyperactive liver, nourishing YIN.Control aphonia cough."
Cymbium melo (sdander): [nature and flavor] salty in the mouth; Property is put down.[return through] lung; Stomach warp.[function cures mainly] relieves inflammation or internal heat improving eyesight.Main dizzy; Blurred vision.
Involucrum Querci fabri: [nature and flavor] are bitter; Puckery; Property is put down.[function cures mainly] spleen invigorating removing food stagnancy, regulates the flow of vital energy, relieves inflammation or internal heat, improving eyesight.Control hernia, infantile malnutrition, acute catarrhal conjunctivitis swelling pain.
Campanilla grass: [nature and flavor] bitter in the mouth; Micro-pungent; Cool in nature.[function cures mainly] clearing away heart-fire; Promoting blood circulation to remove obstruction in the collateral.Main aphtha of the mouth and tongue; Rheumatic arthralgia; Traumatic injury.
Radix rubi pungentis: [nature and flavor] are bitter, puckery, cool.[function cures mainly] pain relieving, antiinflammatory, regulating menstruation.Cure mainly toothache, skin ulcer is leaked, and furuncle swells sore, menoxenia.
Rubus lambertianus Ser.: [nature and flavor] are sweet; Bitter; Flat.[return through] lung; Liver Channel.[function cures mainly] clearing away heat and cooling blood; Detoxification sore treatment.Main cold, fever; Hemoptysis; Have blood in stool; Metrorrhagia; Wound hemorrhage; Scrofula is festered; Skin erosion; Impetigo.
Barnacle: [nature and flavor] salty in the mouth; Cool in nature.[function cures mainly] relieving gastric hyperacidity to alleviate stomachache; Detoxification sore treatment.Main stomachache acid regurgitation; Burn due to hot liquid or fire; Children's's head furuncle; Furuncle swelling toxin.
Mountain standing grain string: [nature and flavor] are sweet, micro-puckery, cool.[function cures mainly] heat clearing away, removing toxic substances, anti-inflammatory analgetic.Cure mainly acute tonsillitis, laryngitis, stomatitis, bronchitis, burn due to hot liquid or fire.[function cures mainly] relieving sore-throat by clearing away heat; Removing toxic substances sore.Main lung-heat abundant expectoration cough; Laryngopharynx swelling and pain; Aphtha of the mouth and tongue; Burn due to hot liquid or fire.
Thalictrum thumbergii D C: [nature and flavor] bitter in the mouth; Cold in nature; Mild toxicity.[function cures mainly] heat-clearing and toxic substances removing dampness.Main pertussis; Carbuncle pyogenic infections from tumour or sore; Control toothache, acute dermatitis, eczema.
Horse small melon: [function cures mainly] be " Zhiwu Mingshi Tukao " 1.: " controlling lymphogranuloma inguinale inguinal bubo, is wash." 2. Guangzhou army " conventional Chinese herbal medicine handbook ": " detumescence and drawing out poison, eliminating phlegm dissipating bond, liver heat removing diuretic.Control carbuncle furuncle to swell, skin eczema, laryngopharynx swelling and pain, parotitis, urinary tract infection, calculus, acute conjunctivitis, infantile malnutrition."
Three marks: [nature and flavor] are micro-sweet, pungent are flat.[function cures mainly] loose poison detumescence, removing heat-phlegm.Cure mainly venom, traumatic injury, eczema, dermatitis, carbuncle furuncle swells, acute/chronic bronchitis.
The invention has the beneficial effects as follows, the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu of the present invention is Chinese medicine and western medicine compound preparation, has Qinghuo Jiedu, expelling wind and removing dampness, promoting blood circulation and cooling blood, effect of analgesic antiphlogistic, can reach the object for the treatment of both the principal and secondary aspects of a disease; And Effective Component of Chinese Medicine is prepared into Nano grade, and effectively improve drug absorption rate, evident in efficacy; Medicament of the present invention is topical agent, adds certain fumet, improves drug smell, easy to use.
Detailed description of the invention
Embodiment 1:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprise: Herba Bassiae Dasyphyllae 30 parts, Herba kalanchoes spathulatae 15 parts, 12 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 10 parts, Rhizoma Stachydis 10 parts, Cymbium melo (sdander) 9 parts, Involucrum Querci fabri 9 parts, campanilla grass 8 parts, Radix rubi pungentis 6 parts, Rubus lambertianus Ser. 5 parts, barnacle 4 parts, mountain standing grain string 3 parts, Thalictrum thumbergii D C 2 parts, horse small melon 2 parts, mark 2 parts for three, alclometasone malonate 0.5 part, nadifloxacin 0.3 part, Eurya nitida 10 parts, also comprise: carbomer 1.2 parts, triethanolamine 10 parts, methyl hydroxybenzoate 1.0 parts, antioxidant 0.2 part, fumet 0.02 part.
Wherein, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.Described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
The preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of this Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 8 times amount soak by water 3 times, each decocting time is 1 hour, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 24h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 6.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 100nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks, Eurya nitidas are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 35Mpa, extraction temperature 30 DEG C, separator pressure 20Mpa, separator temperature 50 DEG C, disengaging time 1.5 hours, carbon dioxide flow 30L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 0.98, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 200nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 60 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1h, sub-bottle packaging, to obtain final product.
Embodiment 2:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprise: Herba Bassiae Dasyphyllae 40 parts, Herba kalanchoes spathulatae 20 parts, 17 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 14 parts, Rhizoma Stachydis 15 parts, Cymbium melo (sdander) 10 parts, Involucrum Querci fabri 11 parts, campanilla grass 10 parts, Radix rubi pungentis 7 parts, Rubus lambertianus Ser. 8 parts, barnacle 5 parts, mountain standing grain string 5 parts, Thalictrum thumbergii D C 4 parts, horse small melon 4 parts, three mark 3 parts, alclometasone malonate 0.5 part, nadifloxacin 0.3 part, also comprise: carbomer 1.3 parts, triethanolamine 12 parts, methyl hydroxybenzoate 1.05 parts, antioxidant 0.3 part, fumet 0.03 part.
Wherein, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.Described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
The preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of this Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 8.5 times amount soak by water 3 times, each decocting time is 1.1 hours, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 25h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 6.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 200nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 36Mpa, extraction temperature 34 DEG C, separator pressure 21Mpa, separator temperature 52 DEG C, disengaging time 1.8 hours, carbon dioxide flow 32L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 0.10, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 220nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 65 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1.2h, sub-bottle packaging, to obtain final product.
Embodiment 3:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprise: Herba Bassiae Dasyphyllae 45 parts, Herba kalanchoes spathulatae 22.5 parts, 18.5 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 15 parts, Rhizoma Stachydis 20 parts, Cymbium melo (sdander) 12 parts, Involucrum Querci fabri 12 parts, campanilla grass 14 parts, Radix rubi pungentis 7.5 parts, Rubus lambertianus Ser. 10 parts, barnacle 7 parts, mountain standing grain string 6.5 parts, Thalictrum thumbergii D C 5 parts, horse small melon 4.5 parts, mark 3.5 parts for three, alclometasone malonate 1.0 parts, nadifloxacin 0.65 part, Eurya nitida 20 parts, also comprise: carbomer 1.5 parts, triethanolamine 13 parts, methyl hydroxybenzoate 1.1 parts, antioxidant 0.35 part, fumet 0.035 part.
Wherein, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.Described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
The preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of this Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 9 times amount soak by water 3 times, each decocting time is 1.25 hours, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 27h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 6.5 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 300nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 37.5Mpa, extraction temperature 32.5 DEG C, separator pressure 22Mpa, separator temperature 54 DEG C, disengaging time 2.0 hours, carbon dioxide flow 33L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 1.05, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 250nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 70 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1.5h, sub-bottle packaging, to obtain final product.
Embodiment 4:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprise: Herba Bassiae Dasyphyllae 50 parts, Herba kalanchoes spathulatae 25 parts, 20 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 16 parts, Rhizoma Stachydis 25 parts, Cymbium melo (sdander) 14 parts, Involucrum Querci fabri 13 parts, campanilla grass 18 parts, Radix rubi pungentis 8 parts, Rubus lambertianus Ser. 12 parts, barnacle 9 parts, mountain standing grain string 8 parts, Thalictrum thumbergii D C 6 parts, horse small melon 5 parts, three mark 4 parts, alclometasone malonate 1.5 parts, nadifloxacin 1.0 parts, also comprise: carbomer 1.7 parts, triethanolamine 14 parts, methyl hydroxybenzoate 1.15 parts, antioxidant 0.4 part, fumet 0.04 part.
Wherein, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.Described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
The preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of this Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 9.5 times amount soak by water 3 times, each decocting time is 1.4 hours, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 29h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 7.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 400nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 39Mpa, extraction temperature 34 DEG C, separator pressure 23Mpa, separator temperature 56 DEG C, disengaging time 2.2 hours, carbon dioxide flow 34L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 1.1, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 280nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 75 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1.8h, sub-bottle packaging, to obtain final product.
Embodiment 5:
A kind of compound recipe Herba Bassiae Dasyphyllae topical agent of Qinghuo Jiedu, by weight, comprise: Herba Bassiae Dasyphyllae 60 parts, Herba kalanchoes spathulatae 30 parts, 25 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 20 parts, Rhizoma Stachydis 30 parts, Cymbium melo (sdander) 15 parts, Involucrum Querci fabri 15 parts, campanilla grass 20 parts, Radix rubi pungentis 9 parts, Rubus lambertianus Ser. 15 parts, barnacle 10 parts, mountain standing grain string 10 parts, Thalictrum thumbergii D C 8 parts, horse small melon 7 parts, mark 5 parts for three, alclometasone malonate 1.5 parts, nadifloxacin 1.0 parts, Eurya nitida 30 parts, also comprise: carbomer 1.8 parts, triethanolamine 16 parts, methyl hydroxybenzoate 1.2 parts, antioxidant 0.5 part, fumet 0.05 part.
Wherein, described antioxidant is tocopherol acetas, has Chinese medicine extract in this medicament, easily oxidized, therefore needs to add certain antioxidant, prevents medicine from going bad, thus ensures drug effect.Described fumet is ethyl propionate, and this medicine is facial medicine for external use, needs to add certain fumet to hide the flavour of a drug of Chinese medicine, improves drug smell.
The preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of this Qinghuo Jiedu, comprises the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 10 times amount soak by water 3 times, each decocting time is 1.5 hours, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 30h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 7.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 500nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks, Eurya nitidas are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 40Mpa, extraction temperature 35 DEG C, separator pressure 24Mpa, separator temperature 58 DEG C, disengaging time 2.5 hours, carbon dioxide flow 36L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 1.12, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 300nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 80 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by;
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 2h, sub-bottle packaging, to obtain final product.
Compliance test result
1, object of study: select clinical tinea barbae patient 200 example of accepting for medical treatment in certain hospital on January 10,1 day to 2014 January in 2014, be divided into 5 groups at random, often organize 40 people, each group patient is without significant difference.
2, verification method: three groups as experimental group, one group as positive controls, one group, as blank group, is designated as respectively: test 1 group, test 2 groups, test 3 groups, positive controls, blank group.Test the medicament that group uses the embodiment of the present invention 1, embodiment 3, embodiment 5 prepares respectively and treat for real three, positive controls use antimicrobial ointment is treated, and blank group does not use any medicine, only carries out simple clean.Within 7 days, be a course for the treatment of, altogether 2 courses for the treatment of of observation.
3, criterion of therapeutical effect: effective: upper lip and chin portion inflammatory hair follicle pimple transference cure; Effective: upper lip and chin portion inflammatory hair follicle pimple symptom are extenuated or disappear; Invalid: without significant change before and after treatment.
4, record also statistical observation result, as shown in table 1:
Therapeutic outcome statistics is respectively organized in the course for the treatment of in table 1-2
| Group | Effective/people | Effectively/people | Invalid/people | Effective percentage/% | Cure rate/% |
| Test 1 group | 32 | 7 | 1 | 97.5 | 80 |
| Test 2 groups | 35 | 5 | 0 | 100 | 87.5 |
| Test 3 groups | 38 | 2 | 0 | 100 | 95 |
| Positive controls | 14 | 19 | 7 | 82.5 | 35 |
| Blank group | 0 | 0 | 40 | 0 | 0 |
5, conclusion: as can be seen from above-mentioned experiment, the effective percentage of medicament of the present invention is minimum reaches 97.5%, is up to 100%, cure rate is minimum is 80, and be up to 95%, its curative effect is apparently higher than positive controls, therefore, medicament of the present invention has good clinical application effect, is worthy to be popularized.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in previous embodiment, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of embodiment of the present invention technical scheme.
Claims (7)
1. the compound recipe Herba Bassiae Dasyphyllae topical agent of a Qinghuo Jiedu, it is characterized in that, by weight, comprising: Herba Bassiae Dasyphyllae 30 ~ 60 parts, Herba kalanchoes spathulatae 15 ~ 30 parts, 12 ~ 25 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 10 ~ 20 parts, Rhizoma Stachydis 10 ~ 30 parts, Cymbium melo (sdander) 9 ~ 15 parts, Involucrum Querci fabri 9 ~ 15 parts, campanilla grass 8 ~ 20 parts, Radix rubi pungentis 6 ~ 9 parts, Rubus lambertianus Ser. 5 ~ 15 parts, barnacle 4 ~ 10 parts, mountain standing grain string 3 ~ 10 parts, Thalictrum thumbergii D C 2 ~ 8 parts, horse small melon 2 ~ 7 parts, three mark 2 ~ 5 parts, alclometasone malonate 0.5 ~ 1.5 part, nadifloxacin 0.3 ~ 1.0 part.
2. the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu according to claim 1, it is characterized in that, by weight, comprise: Herba Bassiae Dasyphyllae 40 ~ 50 parts, Herba kalanchoes spathulatae 20 ~ 25 parts, 17 ~ 20 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 14 ~ 16 parts, Rhizoma Stachydis 15 ~ 25 parts, Cymbium melo (sdander) 10 ~ 14 parts, Involucrum Querci fabri 11 ~ 13 parts, campanilla grass 10 ~ 18 parts, Radix rubi pungentis 7 ~ 8 parts, Rubus lambertianus Ser. 8 ~ 12 parts, barnacle 5 ~ 9 parts, mountain standing grain string 5 ~ 8 parts, Thalictrum thumbergii D C 4 ~ 6 parts, horse small melon 4 ~ 5 parts, mark 3 ~ 4 parts for three, alclometasone malonate 0.5 ~ 1.5 part, nadifloxacin 0.3 ~ 1.0 part.
3. the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu according to claim 1 and 2, it is characterized in that, optimum ratio is: Herba Bassiae Dasyphyllae 45 parts, Herba kalanchoes spathulatae 22.5 parts, 18.5 parts, Musa basjoo Sieb. Et Zucc. head, flat cattail leaf fan 15 parts, Rhizoma Stachydis 20 parts, Cymbium melo (sdander) 12 parts, Involucrum Querci fabri 12 parts, campanilla grass 14 parts, Radix rubi pungentis 7.5 parts, Rubus lambertianus Ser. 10 parts, barnacle 7 parts, mountain standing grain string 6.5 parts, Thalictrum thumbergii D C 5 parts, horse small melon 4.5 parts, three mark 3.5 parts, alclometasone malonate 1.0 parts, nadifloxacin 0.65 part.
4. the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu according to claims 1 to 3 any one, it is characterized in that, by weight, also comprise: carbomer 1.2 ~ 1.8 parts, triethanolamine 10 ~ 16 parts, methyl hydroxybenzoate 1.0 ~ 1.2 parts, antioxidant 0.2 ~ 0.5 part, fumet 0.02 ~ 0.05 part.
5. the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu according to claim 4, is characterized in that, described antioxidant is tocopherol acetas.
6. the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu according to claim 4, is characterized in that, described fumet is ethyl propionate.
7., according to the preparation method of the compound recipe Herba Bassiae Dasyphyllae topical agent of a kind of Qinghuo Jiedu described in claim 1 to 6, it is characterized in that, comprise the following steps:
(1) Herba Bassiae Dasyphyllae is taken by formula, flat cattail leaf fan, Cymbium melo (sdander), Involucrum Querci fabri, campanilla grass, mountain standing grain string, Thalictrum thumbergii D C, horse small melon, clean, chopping, add 8 ~ 10 times amount soak by water 3 times, each decocting time is 1 ~ 1.5 hour, filter, merging filtrate, 95% ethanol is added by the volume ratio of 1:1, stir evenly and dissolve and filter, gained filtrate leaves standstill 24 ~ 30h at normal temperatures, separation obtains supernatant and precipitation, gained precipitate rinses and adjust ph to 6.0 ~ 7.0 with water successively, ethanol is volatilized and drying, obtain dry precipitate powder, gained supernatant concentration becomes extractum, be spray dried to extract powder, precipitate powder and extract powder are merged, the impact grinding of high energy nanometer is adopted to be ground into the micropowder I of particle diameter 100 ~ 500nm, stand-by,
(2) Herba kalanchoes spathulatae, Musa basjoo Sieb. Et Zucc. head, Rhizoma Stachydis, Radix rubi pungentis, Rubus lambertianus Ser., three marks are taken by formula, clean, shred, employing carbon dioxide supercritical extraction method is extracted, extracting pressure is 35 ~ 40Mpa, extraction temperature 30 ~ 35 DEG C, separator pressure 20 ~ 24Mpa, separator temperature 50 ~ 58 DEG C, disengaging time 1.5 ~ 2.5 hours, carbon dioxide flow 30 ~ 36L/h, obtains extracting solution; By extracting solution concentrating under reduced pressure, and under being dried to the temperature conditions of 75 DEG C, relative density is the extractum of 0.98 ~ 1.12, is spray dried to extract powder, adopts the impact grinding of high energy nanometer to be ground into the micropowder II of particle diameter 200 ~ 300nm, stand-by;
(3) take fresh barnacle by formula, clean, mince, with ball mill grinding, grind complete alcohol-pickled extraction 8h, filter with 200 mesh filter screens, obtain filtrate, in 60 ~ 80 DEG C of isothermal holding, treat that ethanol volatilizees completely, obtain barnacle extracting solution, stand-by.
(4) carbomer is dispersed in pure water soaks, treat fully to dissolve to obtain dispersion soln, mix with barnacle extracting solution, add micropowder I again, micropowder II stirs, finally add alclometasone malonate, nadifloxacin, carbomer, triethanolamine, methyl hydroxybenzoate, antioxidant, fumet continuation stirring 1 ~ 2h, sub-bottle packaging, to obtain final product.
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