CN105147389A - Radiofrequency ablation equipment comprising balloon blocking type guide conduit and ablation method thereof - Google Patents
Radiofrequency ablation equipment comprising balloon blocking type guide conduit and ablation method thereof Download PDFInfo
- Publication number
- CN105147389A CN105147389A CN201510689867.7A CN201510689867A CN105147389A CN 105147389 A CN105147389 A CN 105147389A CN 201510689867 A CN201510689867 A CN 201510689867A CN 105147389 A CN105147389 A CN 105147389A
- Authority
- CN
- China
- Prior art keywords
- ablation
- radio
- frequency
- electrode
- catheter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Surgical Instruments (AREA)
Abstract
The invention discloses radiofrequency ablation equipment comprising a balloon blocking type guide conduit and an ablation method thereof. The radiofrequency ablation equipment comprises the two-cavity or multi-cavity balloon blocking type guide conduit and a radiofrequency ablation conduit. An electrode support is arranged at the far end of the radiofrequency ablation conduit. Two or more electrodes are arranged on the electrode support and connected to a radiofrequency generator through corresponding guide wires arranged in the radiofrequency ablation conduit. When the radiofrequency ablation equipment is used for carrying out ablation on the peripheral nerves of the lumen, a closed balloon arranged at the far end of the guide conduit is inflated to obstruct local blood flow in the blood vessel; liquid/gas is injected into the blood vessel at the ablation part through an injection opening in the front end of the guide conduit, electric conduction environment and/or temperature environment are/is changed, the different electrodes of the radiofrequency ablation conduit are controlled so that a loop passing through the wall of the blood vessel can be formed between the radiofrequency electrode and the loop circuit electrode to carry out radiofrequency ablation, and the equipment has an ideal nerve ablation effect.
Description
Technical field
The present invention relates to a kind of radio-frequency (RF) ablation equipment, particularly relate to a kind of radio-frequency (RF) ablation equipment comprising balloon occlusion type guiding catheter, the present invention relates to the radio-frequency (RF) ablation method using above-mentioned radio-frequency (RF) ablation equipment to realize simultaneously, belongs to nerve ablation field.
Background technology
Neuro vegetative exception plays very important effect in the generation of numerous disease, differentiation and development.In recent years, along with the development of Wicresoft's interventional technique, use the symptoms such as the treatment of nerve ablation art hypertension, diabetes, heart disease, cancer to start clinically to apply gradually, and achieve good effect.
Radio frequency ablation catheter is the capital equipment implementing radio-frequency ablation procedure, and guiding catheter is the body being arranged on radio frequency ablation catheter outside, and radio frequency ablation catheter generally all needs to set up under the assistance of guiding catheter from external to heart or arteriorenal passage.In ablative surgery process, the major part of ablation catheter is retained in guiding catheter.
In prior art, radio-frequency (RF) ablation equipment comprises the radiofrequency melting instrument, the radio frequency ablation catheter that are provided with radio-frequency signal generator, and by the radio-frequency electrode that the outfan of the wire with radio-frequency signal generator that are arranged on radio frequency ablation catheter inside is connected, comprise the loop electrode be connected with the loop end of radio-frequency signal generator in addition.Existing in the perineural nerve ablation operation of tube chamber, the loop electrode of radio-frequency (RF) ablation equipment is set to body surface patch electrode usually, is arranged on human external.The concrete structure of this radio-frequency (RF) ablation equipment can be the CN200880126859.X Chinese patent of " carrying out the system and method for impedance measurement for using conduit such as ablation catheter " see denomination of invention.As shown in Figure 1, which disclose conduit and patch electrode system, wherein, the positive pole of radio-frequency (RF) ablation generator (16) is electrically coupled to point electrode (28T) by source lead-in wire (46), the positive pole of sensing adapter (32) is electrically coupled to point electrode (28T), resource loop (56 by sense lead (48)
1) and sensing loop (56
2) be electrically connected to the negative pole of radio-frequency (RF) ablation generator (16) and the negative pole of sensing adapter respectively.Resource loop (56
1) and sensing loop (56
2) being arranged on human external, the pumping signal that the point electrode (28T) being positioned at tube chamber inside sends needs from inside of human body, passes through whole tissue, then through resource loop (56
1) get back to radio-frequency (RF) ablation generator (16).That is, radio-frequency current needs from the tube chambers such as blood vessel, and enter tissue through tube wall, and after whole people's body loop, get back to radio-frequency (RF) ablation generator from human external, radio-frequency current needs through whole tissue in brief.In this radiofrequency ablation procedures, the radio frequency direction of radio-frequency electrode as shown in Figure 2.This nerve ablation mode consisting of the loop of rf whole human body, in radio frequency process, needs to overcome larger human body impedance, therefore, needs to adopt larger voltage, electric current and radio-frequency power, thus inevitably causes damage to human vas.
In addition, in prior art, also exist and radio-frequency electrode and loop electrode to be arranged on same supporter from outside to the equipment that sufferer tissue melts, a kind of scissor RF ablation device that the CN201210128849.8 Chinese patent that such as denomination of invention is " a kind of Multifunctional radio-frequency cooling knife " provides.As shown in Figure 8, this Multifunctional radio-frequency cooling knife comprises the first branch 20 of branch 10, second, connecting end portion 30 and operating grip 40, wherein, first branch 10 and the second branch 20 are respectively arranged with two bipolar radio-frequency electrode, radiofrequency signal between two bipolar radio-frequency electrode are on each limb set and are formed by tissue and enter organization internal and radio-frequency (RF) ablation is carried out in the fractional radio frequency loop getting back to tissue outside from tissue is outside.In above-mentioned radio-frequency (RF) ablation equipment, radio-frequency electrode and loop electrode are all arranged on inside of human body but are in the outside of ablation tissue, in ablation procedure, there is not the fluid flow blood that radio frequency loop exists impact around ablation tissue.When the ablation catheter directly transplanting being provided with radio-frequency electrode and loop electrode on same supporter is melted in tube chamber inside circumvascular plexus nervorum simultaneously, owing to there is the blood of flowing in tube chamber, the formation in the electric conductivity meeting radio frequency loop of blood impacts, thus the loop not easily formed between two electrodes through blood vessel wall or extravascular tissue, now tube chamber peripheral nerve is melted and be difficult to reach desirable effect.
Summary of the invention
Primary technical problem to be solved by this invention is to provide a kind of radio-frequency (RF) ablation equipment comprising balloon occlusion type guiding catheter.
Another technical problem to be solved by this invention is to provide a kind of radio-frequency (RF) ablation method using above-mentioned radio-frequency (RF) ablation equipment to realize.
To achieve these goals, the present invention adopts following technical proposals:
A kind of radio-frequency (RF) ablation equipment, comprise balloon occlusion type guiding catheter, described balloon occlusion type guiding catheter comprises two-chamber or multi-cavity catheter, and the outer wall of the far-end of described guiding catheter is provided with the inflatable closed sacculus for blocking Ink vessel transfusing regional flow; The first conduit branch communicated with the first tube chamber of described guiding catheter inside is provided with at the near-end of described guiding catheter, the inside of described closed sacculus communicates with the first tube chamber of described guiding catheter inside, and described first conduit branch is used for providing inflation thing by described first tube chamber to described closed sacculus; The second conduit branch communicated with the second tube chamber of described guiding catheter inside is provided with at the near-end of described guiding catheter, the far-end of described second tube chamber is provided with perfusing hole, and described second conduit branch is used for by described perfusing hole to ablation site intra-arterial infusion liquid/gas;
In radiofrequency ablation procedures, be arranged on the endovascular regional flow of closed balloon occlusion of the far-end of described balloon occlusion type guiding catheter by inflation; By described second conduit branch to ablation site intra-arterial infusion liquid/gas; And loop is formed between radio-frequency electrode and loop electrode.
Wherein more preferably, also comprise the radio frequency ablation catheter in a certain tube chamber being arranged on described balloon occlusion type guiding catheter inside, the far-end of described radio frequency ablation catheter is provided with electrode suppor, described electrode suppor is provided with two or more electrode, wherein, have a described Electrode connection at least to the outfan of radio-frequency signal generator, form described radio-frequency electrode, and have a described Electrode connection at least to the loop end of radio-frequency signal generator, form described loop electrode.
Wherein more preferably, described radio frequency ablation catheter is arranged in the second tube chamber of described balloon occlusion type guiding catheter inside.
Wherein more preferably, the far-end of described radio frequency ablation catheter is provided with one or morely wears wall electrode, described in wear wall electrode hollow and communicate with the passage of described radio frequency ablation catheter inside, for injecting fluid/gas in blood vessel wall.
Wherein more preferably, wear wall electrode described in and be arranged on adherent position in the middle part of flap electrode suppor; Or, described in wear the leading portion that wall electrode is arranged on rectangular puncture needle.
Wherein more preferably, wear wall electrode described in is radio-frequency electrode or loop electrode simultaneously.
A kind of radio-frequency (RF) ablation method, is used above-mentioned radio-frequency (RF) ablation equipment to melt tube chamber nervus peripheralis, is arranged on the closed endovascular regional flow of balloon occlusion ablation site of the far-end of described balloon occlusion type guiding catheter by inflation; By described guiding catheter to ablation site intra-arterial infusion liquid/gas, change the endovascular conduction environment of ablation site and/or temperature environment; And by controlling the Different electrodes of described radio frequency ablation catheter, being formed between radio-frequency electrode and loop electrode and carrying out radio-frequency (RF) ablation through the loop of blood vessel wall.
Wherein more preferably, described liquid/gas is the liquid/gas for reducing the endovascular electric conductivity of ablation site.
Wherein more preferably, before radio-frequency (RF) ablation, in blood vessel wall, inject the liquid/gas of the resistance for changing blood vessel wall.
Wherein more preferably, described liquid/gas is the liquid/gas for reducing blood vessel wall resistance.
Radio-frequency (RF) ablation equipment provided by the present invention, comprise balloon occlusion type guiding catheter, by the closed sacculus of the far-end of inflation blocking-up type guiding catheter, regional flow during radio-frequency (RF) ablation can be blocked, by to intra-arterial infusion liquid/gas, endovascular temperature environment and/or conduction environment can be changed.This radio-frequency (RF) ablation equipment, does not need to use external electrode, can form loop carry out radio-frequency (RF) ablation between the radio-frequency electrode be arranged on electrode suppor and loop electrode by blood vessel wall.Because blood vessel wall is close to nerve, intracavity not conducting, few radio frequency loss, and there is best radio-frequency (RF) ablation effect.In addition, the liquid/gas that can reduce local electrical resistance can also be injected to blood vessel wall by the wall electrode of wearing of hollow, for increasing between electrode by the conducting degree of blood vessel wall and conducting probability, and when reducing radio-frequency (RF) ablation simultaneously between electrode at the conducting degree of Endovascular and conducting probability.And, the temperature of local can also be reduced by perfusion fluid in vessel lumen and in blood vessel wall, protection local vascular.
Accompanying drawing explanation
Fig. 1 is in prior art, uses body surface patch electrode as the structural representation of the radio frequency ablation system of loop electrode;
Fig. 2 is radio frequency ablation system shown in Fig. 1, discharges radio frequency direction signal during radio frequency in tube chamber;
Fig. 3 is in another prior art, for the structural representation from the outside radio frequency cooling knife sheared it or melt of sufferer tissue;
Fig. 4 is the basic structure schematic diagram of balloon occlusion type guiding catheter provided by the present invention;
Fig. 5 is the working state schematic representation that radio frequency ablation catheter passes the type of balloon occlusion shown in Fig. 4 guiding catheter;
Fig. 6 uses radio-frequency (RF) ablation equipment provided by the invention, and the radio-frequency (RF) ablation schematic diagram after the pipe intra-bladder instillation non-electrically conductive liquid of ablation site;
Fig. 7 is the schematic diagram of the principle of radio-frequency (RF) ablation shown in Fig. 6 at vascular cross-section;
Fig. 8 uses radio-frequency (RF) ablation equipment provided by the invention, and the radio-frequency (RF) ablation schematic diagram after the pipe intra-bladder instillation conducting liquid of ablation site.
Detailed description of the invention
Be described in detail below in conjunction with the drawings and specific embodiments.For ease of illustrating, below the one end near operator's (away from ablation site) is called near-end, the one end away from operator (near ablation site) is called far-end.
In order to change in prior art, when tube chamber nervus peripheralis is melted, need to arrange body surface patch electrode in vitro as loop electrode, body surface patch electrode and radio-frequency electrode is relied on to form the ablation mode that people's body loop carries out radio-frequency (RF) ablation, the invention provides the radio-frequency (RF) ablation equipment 300 comprising balloon occlusion type guiding catheter, radio frequency ablation catheter and radio-frequency signal generator (not shown) as shown in Figure 4 and Figure 5, and provide the radio-frequency (RF) ablation method using above-mentioned radio-frequency (RF) ablation equipment to melt tube chamber nervus peripheralis simultaneously.Above-mentioned radio-frequency (RF) ablation equipment and radio-frequency (RF) ablation method, can be used for the radiofrequency ablation therapy of cavity tissue, as the treatment that vein blood vessel, endometrium and esophagus inwall melt.
As shown in Figure 4, balloon occlusion type guiding catheter 310 is two-chamber or multi-cavity catheter.The outer wall of the far-end (namely entering one end of human body) of guiding catheter 310 is provided with inflatable closed sacculus 311.The near-end (namely away from one end of human body) of guiding catheter 310 is provided with the first conduit branch 312 communicated with the first tube chamber of guiding catheter 310 inside, the inside of closed sacculus 311 communicates with the first tube chamber of guiding catheter 310 inside, and the first conduit branch 312 is for providing inflation thing by the first tube chamber to closed sacculus 311.In closed sacculus 311, the inflation effect of gas or the closed sacculus 311 of liquid realization is specifically sent into by the inflation equipment (not shown) being connected to the first conduit branch 312 end.The second conduit branch 313 communicated with second tube chamber (i.e. irrigation lumen) of guiding catheter 310 inside is also provided with at the near-end of guiding catheter 310, the far-end of irrigation lumen is provided with perfusing hole, and irrigation lumen is used for by perfusing hole to ablation site intra-arterial infusion liquid/gas.Perfusion equipment (not shown) is connected with at the end of the second conduit branch 313, for passing through the second conduit branch 313, irrigation lumen and perfusing hole to ablation site intra-arterial infusion liquid, as: contrast agent etc., perfusion direction can see the arrow of Fig. 4 medium vessels inside, in addition, also to ablation site intra-arterial infusion gas, such as, CO can be poured into
2deng.Closed sacculus 311 can be concordant with the distal perfusion port of guiding catheter 1, closed sacculus 311 also can and the distal perfusion port of guiding catheter 1 between keep a segment distance to arrange, thus be convenient to blocking-up Ink vessel transfusing blood flow, and be convenient to intra-arterial infusion liquid/gas.Above-mentioned balloon occlusion type guiding catheter 310, the endovascular regional flow of ablation site can be blocked by the closed sacculus 311 of inflation far-end, by can change the endovascular temperature environment of ablation site or conduction environment to ablation site intra-arterial infusion liquid (such as, non-electrically conductive liquid)/gas.
As shown in Figure 5, radio frequency ablation catheter 320 is arranged in a certain tube chamber of balloon occlusion type guiding catheter 310 inside, such as be arranged in the second tube chamber, thus can by the gap between radio frequency ablation catheter 320 and the second tube chamber to ablation site intra-arterial infusion liquid/gas; Radio frequency ablation catheter 320 also can be arranged in other tube chambers outside removing first tube chamber of balloon occlusion type guiding catheter 310 inside and the second tube chamber.The far-end of radio frequency ablation catheter 320 is provided with electrode suppor 321, electrode suppor 321 is provided with two or more electrode 322; Electrode suppor 321 is expansible and shrink, after electrode suppor 321 is expanded, and partly or entirely adherent in multiple electrode 322.Electrode 322 be connected to by the corresponding lead being arranged on radio frequency ablation catheter inside be arranged on radiofrequency melting instrument inside radio-frequency signal generator on; Wherein, in multiple electrode 322, have at least an electrode to be radio-frequency electrode 325, radio-frequency electrode 325 is connected to the outfan of radio-frequency signal generator, and has at least an electrode to be loop electrode 326, and loop electrode 326 is connected to the loop end of radio-frequency signal generator; Multiple radio-frequency electrode 325 can share the same circuit electrode 326 and form loop.When after internal blood vessel conduction environment change, control by radiofrequency melting instrument Different electrodes 322 conducting being arranged on radio frequency ablation catheter 320 far-end, can be formed between corresponding radio-frequency electrode and loop electrode and carry out radio frequency by the loop of blood vessel wall.Therefore, do not need to use body surface patch electrode to form loop in above-mentioned radio-frequency (RF) ablation equipment.
In addition, can also arrange at the far-end of radio frequency ablation catheter 320 and one or morely wear wall electrode.Wear wall electrode can be arranged on electrode suppor, wear wall electrode and also can be set directly on the strip connecting duct of radio frequency ablation catheter.Wear wall electrode hollow and communicate with the passage of radio frequency ablation catheter inside, for injecting fluid/gas in blood vessel wall.Such as, when the shape of electrode suppor is flap, wear wall electrode and can be arranged on adherent position in the middle part of flap electrode suppor; And for example, when the shape of electrode suppor is rectangular puncture aciculiform, the leading portion that wall electrode can be set directly at rectangular puncture needle is worn.When wearing wall electrode and being arranged on electrode suppor, wearing wall electrode can independently be arranged, and wearing wall electrode can also be radio-frequency electrode or loop electrode simultaneously.
Below in conjunction with Fig. 6 to Fig. 8, radio-frequency (RF) ablation equipment provided by the invention and radio-frequency (RF) ablation principle thereof are described.
First embodiment
As shown in Figure 6, this radio-frequency (RF) ablation equipment comprises guiding catheter 310, radio frequency ablation catheter 320, and also comprise the radiofrequency melting instrument (not shown) for controlling radio frequency process, radio frequency ablation catheter 320 is connected with radiofrequency melting instrument.Radio frequency ablation catheter 320 comprises the connecting duct of strip, is arranged on the electrode suppor 321 of connecting duct far-end, and is arranged on the joystick of connecting duct near-end.During use, joystick is connected with radiofrequency melting instrument by composite cable, is provided with the many wires for connecting Different electrodes and radio-frequency signal generator in composite cable.Electrode suppor 321 is provided with multiple electrode 322, when the front end of radio frequency ablation catheter 320 is stretched out from guiding catheter 310, and after multiple electrode 322 is adherent under the effect of joystick, the Different electrodes 322 that can control to be arranged on radio frequency ablation catheter 320 front end by radiofrequency melting instrument respectively carries out radio frequency release.When after the endovascular conduction environment of change ablation site, in radio frequency dispose procedure, rely on the blood vessel wall between Different electrodes can form loop and carry out radio-frequency (RF) ablation.Do not need to use body surface patch electrode in this radio-frequency (RF) ablation equipment.
As shown in Figure 6 and Figure 7, after the closed sacculus 311 of inflation blocks the endovascular regional flow of ablation site, by the second conduit branch 313 after ablation site pipe intra-bladder instillation contrast agent or other non-electrically conductive liquids, control radio-frequency electrode is adherent, then radio-frequency electrode 325 and loop electrode 326 can form loop through blood vessel wall and carry out radio frequency.Now, as shown in Figure 7, portion radio frequency electric current can from the radio-frequency electrode 325 intravasation wall 400 of tube chamber inside, and from after flowing through blood vessel wall 400 between blood vessel wall inner surface 401 and outer surface 402, gets back to the loop electrode 326 of tube chamber inside; Meanwhile, portion radio frequency electric current can enter from the inner surface 401 of blood vessel wall and pass through blood vessel wall outer surface 402 after blood vessel wall 400, and from the outside of blood vessel wall outer surface 402 again intravasation wall 400, then flows through blood vessel wall 400 and get back to loop electrode 326.In this process, radio-frequency current from the part flow through between blood vessel wall inner surface 401 and outer surface 402 and radio-frequency current through intravasation wall again after blood vessel wall part ratio determined by the conductivity difference of blood vessel wall and blood vessel wall peripheral organization.
Now, because contrast agent is non-conductor, resistance is very high, and intracavity belongs to non-conductive environment, and intracavity not conducting does not now need by external electrode, can realize mutual electron motion carry out radio frequency between electrode by blood vessel wall.By controlling the order of radio frequency mutually between Different electrodes, getting final product the transmit direction of radio frequency between control electrode, realizing the radio-frequency (RF) ablation of the nervous tissue of the outer different parts of blood vessel wall.When adopting such scheme, blood vessel wall is conductor, and because blood vessel wall is close to nerve, few radio frequency loss, the neural effect of radio-frequency (RF) ablation is perfect condition.Therefore, by reducing the liquid of intracavity electric conductivity to the intra-arterial infusion of blocking blood flow, it is suitable that such as non-electrically conductive liquid carries out melting, and can have good nerve ablation effect.Further, the non-electrically conductive liquid be poured in vessel lumen can also reduce the temperature of local tube chamber, protection local vascular.Certainly, also identical object can be realized by the intra-arterial infusion gas to blocking blood flow.
As shown in Figure 8, liquid or gas can be filled with in closed sacculus 311 by the first conduit branch 312, realize the inflation effect of closed sacculus 311, thus block endovascular blood flow.Can to ablation site intra-arterial infusion normal saline by the second conduit branch 313.When by the second conduit branch 313 after ablation site intra-arterial infusion normal saline or other conductive liquids, during the adherent radio frequency of radio-frequency electrode, because normal saline has electric conductivity, intracavity is conduction environment, belong to intracavity to communicate, in electrode, electronics is freely movable at Ink vessel transfusing, forms pipe inner looping.In partial nerve ablative surgery, need to Endovascular perfusion normal saline, now, the liquid/gas of blood vessel wall local electrical resistance can be reduced by injection in blood vessel wall, blood vessel wall is made to have the good electric conductivity of relative intracavity, thus can be formed to be similar in blood vessel wall and outside organization thereof and melt loop shown in Fig. 6 and Fig. 7, reach the effect melting nervous tissue.
Second embodiment
In this embodiment, the structure of radio-frequency (RF) ablation equipment is substantially identical with the first embodiment, comprises above-mentioned balloon occlusion type guiding catheter, radio frequency ablation catheter and the radiofrequency melting instrument be connected with radio frequency ablation catheter.The difference of the second embodiment and the first embodiment is: the far-end of radio frequency ablation catheter is also provided with hollowly wears wall electrode, wear wall electrode hollow and communicate with the inner passage of radio frequency ablation catheter, for injecting the liquid of the resistance for changing blood vessel wall in blood vessel wall, such as, can be fall low-resistance normal saline.Wearing wall electrode can be arranged on radio-frequency electrode on electrode suppor or loop electrode, also can be the electrode being specifically designed to injection arranged in addition.
Wear wall electrode and its far-end is provided with outlet, wear wall electrode and its near-end is provided with import, import communicates with the inner passage of radio frequency ablation catheter.Be provided with the intrusion pipe communicated with its inner passage in the rear end of radio frequency ablation catheter, intrusion pipe is used for being connected with perfusion equipment.Wall electrode and intrusion pipe is worn by hollow, normal saline etc. can be injected directly in the tube wall tissue near radio-frequency (RF) ablation point for reducing the material of blood vessel wall local electrical resistance by perfusion equipment, for increasing between electrode by the conducting degree of blood vessel wall and conducting probability, and when reducing radio-frequency (RF) ablation simultaneously between electrode at the conducting degree of Endovascular and conducting probability.
Therefore, in radiofrequency ablation procedures, be arranged on the endovascular regional flow of closed balloon occlusion of the far-end of guiding catheter by inflation; By guiding catheter to the liquid/gas of intra-arterial infusion for reducing intracavity electric conductivity; And in vascular wall tissue, inject liquid for reducing local electrical resistance by hollow wall electrode of wearing simultaneously, then by controlling the Different electrodes of radio frequency ablation catheter, can be formed between radio-frequency electrode and loop electrode and carry out radio-frequency (RF) ablation through the loop of blood vessel wall, nerve ablation effect is better than the first embodiment.
Specifically, what be arranged on radio frequency ablation catheter 2 far-end wears wall electrode, can be arranged on the adherent position in the middle part of flap radio-frequency electrode, also can be arranged on the leading portion of rectangular puncture needle radio-frequency electrode.And wear wall electrode front end and be set to sharp keen acute angle, can have sword, profile is conical, and rhombus etc., wear the length range of wall electrode, is preferably: 0.01 ~ 20mm, wears the diameter range of wall electrode, is preferably 0.01 ~ 2.0mm.
3rd embodiment
In this embodiment, in order to realize the liquid injected in the blood vessel wall of ablation site for reducing local electrical resistance, being provided with the puncture needle of hollow in the front end of radio frequency ablation catheter, wearing the function of injection of wall electrode for replacing hollow in the second embodiment.What arrange in this embodiment wears the function that wall electrode or ordinary electrode only have radio-frequency (RF) ablation, or wears the structure that wall electrode also can have hollow simultaneously and have function of injection.Wherein, wear wall electrode to penetrate or through after blood vessel wall, can release energy directly to the plexus nervorum near blood vessel wall, thus reduce radio frequency process to the damage of blood vessel wall, can see the introduction in the application for a patent for invention CN201310049148.X of the applicant about the introduction of wearing wall electrode.In this embodiment, all the other structures of radio-frequency (RF) ablation equipment are substantially identical with the second embodiment, comprise above-mentioned balloon occlusion type guiding catheter, radio frequency ablation catheter and the radiofrequency melting instrument be connected with radio frequency ablation catheter.
In the radio frequency ablation catheter that the present embodiment provides, be provided with the liquid cavity be communicated with puncture needle, and be connected with outside perfusion equipment by conduit branch.By conduit branch and puncture needle, the material that normal saline etc. can be reduced blood vessel wall local electrical resistance by perfusion equipment is injected directly in the tube wall tissue near radio-frequency (RF) ablation point, for increasing between electrode by the conducting degree of blood vessel wall and conducting probability, and when reducing radio-frequency (RF) ablation simultaneously between electrode at the conducting degree of Endovascular and conducting probability.
Therefore, in radiofrequency ablation procedures, be arranged on the endovascular regional flow of closed balloon occlusion of the far-end of guiding catheter by inflation; By guiding catheter to intra-arterial infusion for changing the liquid/gas of Ink vessel transfusing electric conductivity, preferably reduce the liquid/gas of electric conductivity, change the endovascular conduction environment of ablation site and temperature environment; And in vascular wall tissue, inject the liquid for reducing blood vessel wall local electrical resistance by puncture needle simultaneously, then by controlling the Different electrodes of radio frequency ablation catheter, can be formed between radio-frequency electrode and loop electrode and carry out radio-frequency (RF) ablation through the loop of blood vessel wall, nerve ablation effect is better than the first embodiment equally.
In sum, the radio-frequency (RF) ablation equipment comprising balloon occlusion type guiding catheter provided by the present invention, by the closed sacculus of the far-end of balloon inflation blocking-up type guiding catheter, the endovascular regional flow of ablation site can be blocked, by to ablation site intra-arterial infusion for changing Ink vessel transfusing conduction environment or the liquid/gas of temperature environment, and by controlling the Different electrodes of radio frequency ablation catheter, between radio-frequency electrode and loop electrode, loop can be formed by blood vessel wall or its peripheral organization and carrying out radio frequency.Adopt the radio-frequency (RF) ablation equipment of above-mentioned guiding catheter, do not need external electrode, namely by the transmit direction of radio frequency between control electrode, between different electrodes, form loop by blood vessel wall carry out radio-frequency (RF) ablation.This formed between radio-frequency electrode and loop electrode through the loop of blood vessel wall relative to the loop formed through whole human body, belong to the loop formed in regional area, need to overcome human body impedance few.And because blood vessel wall is close to nerve, intracavity not conducting, few radio frequency loss, can have desirable nerve ablation effect.
In addition, wall electrode or puncture needle can to reduce liquid from local electrical resistance to blood vessel wall perfusion can also be worn by hollow, for increasing between electrode by the conducting degree of blood vessel wall and conducting probability, and when reducing radio-frequency (RF) ablation simultaneously between electrode at the conducting degree of Endovascular and conducting probability.And, by perfusion fluid in vessel lumen and in blood vessel wall tube wall tissue injecting fluid, the temperature of local can also be reduced, protection local vascular simultaneously.
The radiofrequency melting instrument that the present invention uses possesses multi-channel rf output function, can realize forming loop through blood vessel wall between multiple electrode, radiofrequency melting instrument by the various form electrodes of ablation catheter radio-frequency (RF) energy is loaded into fit with it blood vessel, muscle, on nerve, then radio-frequency current gets back to radiofrequency melting instrument through blood vessel wall by loop electrode, forms radio frequency and loads loop.Radio-frequency current produces ion high speed vibration in the tissue of fitting with it, and produces temperature rise and melt object to reach.
In technical scheme provided by the invention, above-mentioned radiofrequency melting instrument can realize forming fractional radio frequency's current loop through blood vessel wall between electrode between two, only between two electrodes forming loop, discharge radio-frequency (RF) energy, and produce temperature, greatly reduce more radio-frequency (RF) energy of human body impedance loss.
In two applications for a patent for invention submitted to " 201410035836.5 for the radio-frequency (RF) ablation method of nerve ablation and radio frequency ablation system " and " 201310530007.X has temp sensing function concurrently and surveys radio-frequency electrode and the ablatograph of impedance function ", illustrate the operation principle of radiofrequency melting instrument in detail, do not repeat them here.
The radio-frequency (RF) ablation equipment comprising balloon occlusion type guiding catheter to provided by the present invention above and ablation method thereof have been described in detail.To those skilled in the art, to any apparent change that it does under the prerequisite not deviating from connotation of the present invention, all by formation to infringement of patent right of the present invention, corresponding legal responsibility will be born.
Claims (10)
1. a radio-frequency (RF) ablation equipment, is characterized in that:
Comprise balloon occlusion type guiding catheter, described balloon occlusion type guiding catheter comprises two-chamber or multi-cavity catheter, and the outer wall of the far-end of described guiding catheter is provided with the inflatable closed sacculus for blocking Ink vessel transfusing regional flow; The first conduit branch communicated with the first tube chamber of described guiding catheter inside is provided with at the near-end of described guiding catheter, the inside of described closed sacculus communicates with the first tube chamber of described guiding catheter inside, and described first conduit branch is used for providing inflation thing by described first tube chamber to described closed sacculus; The second conduit branch communicated with the second tube chamber of described guiding catheter inside is provided with at the near-end of described guiding catheter, the far-end of described second tube chamber is provided with perfusing hole, and described second conduit branch is used for by described perfusing hole to ablation site intra-arterial infusion liquid/gas;
In radiofrequency ablation procedures, be arranged on the endovascular regional flow of closed balloon occlusion of the far-end of described balloon occlusion type guiding catheter by inflation; By described second conduit branch to ablation site intra-arterial infusion liquid/gas; And loop is formed between radio-frequency electrode and loop electrode.
2. radio-frequency (RF) ablation equipment as claimed in claim 1, is characterized in that:
Also comprise the radio frequency ablation catheter in a certain tube chamber being arranged on described balloon occlusion type guiding catheter inside, the far-end of described radio frequency ablation catheter is provided with electrode suppor, described electrode suppor is provided with two or more electrode, wherein, has a described Electrode connection at least to the outfan of radio-frequency signal generator, form described radio-frequency electrode, and have a described Electrode connection at least to the loop end of radio-frequency signal generator, form described loop electrode.
3. radio-frequency (RF) ablation equipment as claimed in claim 1, is characterized in that:
Described radio frequency ablation catheter is arranged in the second tube chamber of described balloon occlusion type guiding catheter inside.
4. radio-frequency (RF) ablation equipment as claimed in claim 1, is characterized in that:
The far-end of described radio frequency ablation catheter is provided with one or morely wears wall electrode, described in wear wall electrode hollow and communicate with the passage of described radio frequency ablation catheter inside, for injecting fluid/gas in blood vessel wall.
5. radio-frequency (RF) ablation equipment as claimed in claim 4, is characterized in that:
Described wall electrode of wearing is arranged on adherent position in the middle part of flap electrode suppor; Or, described in wear the leading portion that wall electrode is arranged on rectangular puncture needle.
6. radio-frequency (RF) ablation equipment as claimed in claim 4, is characterized in that:
Described wall electrode of wearing is radio-frequency electrode or loop electrode simultaneously.
7. a radio-frequency (RF) ablation method, uses the radio-frequency (RF) ablation equipment according to any one of claim 1 ~ 6 to melt tube chamber nervus peripheralis, it is characterized in that:
The closed endovascular regional flow of balloon occlusion ablation site of the far-end of described balloon occlusion type guiding catheter is arranged on by inflation; By described balloon occlusion type guiding catheter to ablation site intra-arterial infusion liquid/gas, change the endovascular conduction environment of ablation site and/or temperature environment; And by controlling the Different electrodes of described radio frequency ablation catheter, being formed between described radio-frequency electrode and described loop electrode and carrying out radio-frequency (RF) ablation through the loop of blood vessel wall.
8. radio-frequency (RF) ablation method as claimed in claim 7, is characterized in that:
Described liquid/gas is the liquid/gas for reducing the endovascular electric conductivity of ablation site.
9. radio-frequency (RF) ablation method as claimed in claim 7, is characterized in that:
Before radio-frequency (RF) ablation, in blood vessel wall, inject the liquid/gas of the resistance for changing blood vessel wall.
10. radio-frequency (RF) ablation method as claimed in claim 9, is characterized in that:
Described liquid/gas is the liquid/gas of the resistance for reducing blood vessel wall.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510689867.7A CN105147389B (en) | 2015-10-22 | 2015-10-22 | Include the radio frequency ablation device and its ablation method of balloon occlusion type guiding catheter |
| ES16856948T ES2951175T3 (en) | 2015-10-22 | 2016-10-22 | Radiofrequency ablation device comprising a balloon locking catheter and an ablation method therefor |
| US16/064,934 US20190008585A1 (en) | 2015-10-22 | 2016-10-22 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
| PCT/CN2016/102980 WO2017067517A1 (en) | 2015-10-22 | 2016-10-22 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
| EP16856948.1A EP3366246B1 (en) | 2015-10-22 | 2016-10-22 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
| US17/929,592 US20230181245A1 (en) | 2015-10-22 | 2022-09-02 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510689867.7A CN105147389B (en) | 2015-10-22 | 2015-10-22 | Include the radio frequency ablation device and its ablation method of balloon occlusion type guiding catheter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105147389A true CN105147389A (en) | 2015-12-16 |
| CN105147389B CN105147389B (en) | 2018-03-16 |
Family
ID=54788697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510689867.7A Active CN105147389B (en) | 2015-10-22 | 2015-10-22 | Include the radio frequency ablation device and its ablation method of balloon occlusion type guiding catheter |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105147389B (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017067517A1 (en) * | 2015-10-22 | 2017-04-27 | 上海魅丽纬叶医疗科技有限公司 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
| CN106725838A (en) * | 2016-02-11 | 2017-05-31 | 上海魅丽纬叶医疗科技有限公司 | Have the conduit and its ablation method of balloon expandable and RF ablation function concurrently |
| CN107374725A (en) * | 2017-08-31 | 2017-11-24 | 苏州信迈医疗器械有限公司 | A kind of multipole ablating device |
| CN110191688A (en) * | 2016-10-26 | 2019-08-30 | 波士顿科学医学有限公司 | Narrow prevention and ablation delivery system |
| US10842560B2 (en) | 2017-09-08 | 2020-11-24 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000066018A1 (en) * | 1999-05-04 | 2000-11-09 | Curon Medical, Inc. | Expandable electrode assemblies |
| CN1278711A (en) * | 1997-09-11 | 2001-01-03 | 维纳斯医学技术公司 | Expandable vein ligator catheter and method of use |
| CN102631241A (en) * | 2012-04-27 | 2012-08-15 | 北京优美高电子科技有限公司 | Multifunctional radio frequency cooling knife |
| CN103271765A (en) * | 2013-02-07 | 2013-09-04 | 董永华 | Catheter and device for nerve ablation in cavity-passing and wall-penetrating mode and method for nerve ablation |
| CN205163235U (en) * | 2015-10-22 | 2016-04-20 | 上海魅丽纬叶医疗科技有限公司 | Radio frequency of blocking type guide pipe including sacculus melts equipment |
-
2015
- 2015-10-22 CN CN201510689867.7A patent/CN105147389B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1278711A (en) * | 1997-09-11 | 2001-01-03 | 维纳斯医学技术公司 | Expandable vein ligator catheter and method of use |
| WO2000066018A1 (en) * | 1999-05-04 | 2000-11-09 | Curon Medical, Inc. | Expandable electrode assemblies |
| CN102631241A (en) * | 2012-04-27 | 2012-08-15 | 北京优美高电子科技有限公司 | Multifunctional radio frequency cooling knife |
| CN103271765A (en) * | 2013-02-07 | 2013-09-04 | 董永华 | Catheter and device for nerve ablation in cavity-passing and wall-penetrating mode and method for nerve ablation |
| CN205163235U (en) * | 2015-10-22 | 2016-04-20 | 上海魅丽纬叶医疗科技有限公司 | Radio frequency of blocking type guide pipe including sacculus melts equipment |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017067517A1 (en) * | 2015-10-22 | 2017-04-27 | 上海魅丽纬叶医疗科技有限公司 | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor |
| CN106725838A (en) * | 2016-02-11 | 2017-05-31 | 上海魅丽纬叶医疗科技有限公司 | Have the conduit and its ablation method of balloon expandable and RF ablation function concurrently |
| CN106725838B (en) * | 2016-02-11 | 2024-03-29 | 上海魅丽纬叶医疗科技有限公司 | Catheter with balloon dilation and radio frequency ablation functions and ablation method thereof |
| CN110191688A (en) * | 2016-10-26 | 2019-08-30 | 波士顿科学医学有限公司 | Narrow prevention and ablation delivery system |
| CN107374725A (en) * | 2017-08-31 | 2017-11-24 | 苏州信迈医疗器械有限公司 | A kind of multipole ablating device |
| CN107374725B (en) * | 2017-08-31 | 2023-11-03 | 苏州信迈医疗器械有限公司 | Multipole ablation device |
| US10842560B2 (en) | 2017-09-08 | 2020-11-24 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
| US11925409B2 (en) | 2017-09-08 | 2024-03-12 | Zidan Medical Inc. | Devices and methods for treating lung tumors |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105147389B (en) | 2018-03-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN205163235U (en) | Radio frequency of blocking type guide pipe including sacculus melts equipment | |
| CN105147389A (en) | Radiofrequency ablation equipment comprising balloon blocking type guide conduit and ablation method thereof | |
| CN103919606B (en) | Magnetic navigation cold brine perfusion radio frequency ablation catheter | |
| DE4425015C2 (en) | Endoscopic electrosurgical device | |
| CN102711640B (en) | Endometrial ablation devices and system | |
| CN203539434U (en) | Multi-electrode ablation catheter | |
| CN203280485U (en) | Multi-electrode ablation catheter | |
| CN106974722A (en) | Conduit with perforated tip | |
| KR20040092614A (en) | Electrode for radiofrequency tissue ablation | |
| US20070265617A1 (en) | Dilation catheter assembly with bipolar cutting element | |
| US20160361111A1 (en) | Electrode arrangement | |
| CN104095679A (en) | Multiple-electrode ablation catheter | |
| CN104287827A (en) | Renal sympathetic nerve removing radiofrequency ablation electrode and system | |
| CN104042331A (en) | Catheter with spray irrigation | |
| CN102860868A (en) | Water injection system of double-pole operation electrode and method | |
| TWI680742B (en) | Ablation needle device and high-frequency ablation treatment system for tumors | |
| CN103989521A (en) | Catheter ablation device and radiofrequency ablation catheter of catheter ablation device | |
| CN203970536U (en) | A kind of catheter ablation device and radio frequency ablation catheter thereof | |
| CN106109006B (en) | Radio frequency ablation catheter through coronary venous system | |
| CN104822336B (en) | conduit system | |
| WO2017067517A1 (en) | Radio frequency ablation device comprising balloon blocking catheter and ablation method therefor | |
| CN203763238U (en) | Magnetic navigation cold saline solution pouring radiofrequency ablation catheter | |
| CN202933013U (en) | Balloon dilatation type multi-electrode radiofrequency ablation catheter | |
| CN106102626A (en) | Plasma disposal system | |
| CN104822335B (en) | Conduit system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |