CN104822335B - Conduit system - Google Patents
Conduit system Download PDFInfo
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- CN104822335B CN104822335B CN201380062501.6A CN201380062501A CN104822335B CN 104822335 B CN104822335 B CN 104822335B CN 201380062501 A CN201380062501 A CN 201380062501A CN 104822335 B CN104822335 B CN 104822335B
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- electric power
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- flow
- control unit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
- A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
- A61B2018/00029—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids open
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
- A61B2018/00345—Vascular system
- A61B2018/00351—Heart
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00696—Controlled or regulated parameters
- A61B2018/00744—Fluid flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00779—Power or energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00636—Sensing and controlling the application of energy
- A61B2018/00773—Sensed parameters
- A61B2018/00791—Temperature
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1467—Probes or electrodes therefor using more than two electrodes on a single probe
Abstract
The present invention provides a kind of conduit system for carrying out appropriate perfusion action.Conduit system 5 possesses the ablation catheter 1 with filling mechanism, the power supply unit 32 that electric power when melting is supplied to ablation catheter 1, the liquid supply unit 21 and control unit 35 that perfusion liquid is supplied to ablation catheter 1.When actual measurement electric power Pm of the control unit 35 in ablation is more than threshold value electric power Pth high power state, control turns into big flow and acted；On the other hand, when it is the low power state less than threshold value electric power Pth to survey electric power Pm, control turns into low discharge and acted.In addition, when changing paramount power state from low power state, big flow action is rapidly switched to from low discharge action；On the other hand, when being changed from high power state to low power state, in the conversion in the case where low power state continue for the 1st stand-by time, big flow action is switched into low discharge action after the 1st stand-by time has been maintained.
Description
Technical field
Possess for example for treating cardiac arrhythmia and being melted in the affected part of the treatment the present invention relates to a kind of
(ablation) conduit system of the filling mechanism of the liquid such as saline injection when.
Background technology
Electrode catheter is by (such as endocardial) in blood vessel insertion body, for checking and treating cardiac arrhythmia.This electricity
In general, the shape of front end (distal end) nearby in insertion body is according to the operation in operations described below portion, and a side for pole conduit
To or both direction on change (deflection, bending), the operating portion is arranged on and is configured at external cardinal extremity (near-end, rear end, on hand)
On.In addition, in addition to the type that the shape of this front end can arbitrarily change according to operation, also there is the shape near front end to fix
Type.
However, being used for the conduit (so-called ablation catheter) treated in this electrode catheter, may be sent out when affected part melts
Raw problems with.That is, during the ablative surgery of heart etc., it may occur however that the excessive temperature because disposing part causes rising
The problems such as damaging and adhering to thrombus in disposal part.
Then, as the method for solving this problem, can use has the liquid such as energy saline injection in ablation
Filling mechanism conduit system (for example, patent document 1,2).The conduit system is because in ablation from the front end of ablation catheter
Electrode flows out aforesaid liquid, so affected part can be cooled down, prevents thrombus.
Prior art literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 2006-239414 publications；
Patent document 2：Japanese Unexamined Patent Publication 2012-176119 publications.
The content of the invention
However, in a general case, if possessing the conduit system of above-mentioned filling mechanism to the liquid of disposal part discharge
Flow it is excessive, then dispose part temperature reduce, it is possible to treatment when disposal produce harmful effect.If in addition, liquid
Into excessive in vivo, it is also possible to increase the burden of patient.On the other hand, if the flow of liquid is very few, it is possible to dispose part
The improvement of cooling and hypostasis becomes insufficient.For all these reasons, it is necessary to adjust (management) liquid according to behaviour in service
The flow of body, so as to realize appropriate perfusion action.
The present invention makes in view of the above problems, and its object is to provide a kind of to carry out appropriate perfusion action
Conduit system.
The conduit system of the present invention possesses the ablation catheter with filling mechanism, supplies electricity when melting to the ablation catheter
The power supply unit of power, the liquid supply unit that perfusion liquid is supplied to ablation catheter and the supply of the electric power of control power supply unit respectively
The control unit of the supply action of the liquid of action and liquid supply unit.Control unit ablation when actual measurement electric power for threshold value electric power with
On high power state when, control turns into fluid flow relatively large number of big flow action (the large flow rate
operation)；On the other hand, when it is the low power state less than above-mentioned threshold value electric power to survey electric power, control turns into liquid flow
Measure relatively small number of low discharge action (the small flow rate operation).In addition, from above-mentioned low power state
When conversion is to above-mentioned high power state, above-mentioned big flow action is rapidly switched to from the action of above-mentioned low discharge；On the other hand, exist
When changing from above-mentioned high power state to above-mentioned low power state, in the conversion low power state continue for the 1st it is standby when
Between in the case of, the action of above-mentioned big flow is switched into after above-mentioned 1st stand-by time has been maintained above-mentioned low discharge and acted.
In the conduit system of the present invention, above-mentioned control unit is controlled as follows：From above-mentioned low power state change to
During above-mentioned high power state, above-mentioned big flow action is rapidly switched to from the action of above-mentioned low discharge；On the other hand, from above-mentioned
When high power state is changed to above-mentioned low power state, the feelings of the 1st stand-by time are continue in low power state in the conversion
Under condition, the action of above-mentioned big flow is switched into above-mentioned low discharge after above-mentioned 1st stand-by time has been maintained and acted.Therefore, exist
The flow that liquid occurs very few situation (situation of fluid low) can be avoided during electrical power conversion.
In the conduit system of the present invention, above-mentioned control unit is preferably only being judged as that the small standby flow of fluid flow moves
In the case of making after starting, receive the indication signal for starting ablation.So form, before ablation starts, ablation can be made
(for example, in the space flowed for liquid) is hydraulically full in conduit.Therefore, front end of such as blood from ablation catheter can be avoided
Partly (for example, tap hole of liquid) flows into the danger internal, thrombus blocks internal (for example, in above-mentioned space).In addition,
In this case, above-mentioned control unit more preferably in the case where receiving above-mentioned indication signal, is cut from above-mentioned standby flow action
After changing above-mentioned low discharge action into, act the supply of above-mentioned electric power and start.So form, because the in general supply of liquid
(arrival) more expends the time than power supply, so can avoid that the shape of fluid low occurs due to such service time difference
Condition, more appropriate perfusion action can be achieved.
In the conduit system of the present invention, above-mentioned control unit is preferably when making the supply of above-mentioned electric power act stopping, in electricity
After the supply action of power stops and after the 2nd stand-by time, act its conversion to above-mentioned standby flow.So form, energy
The cooling using liquid for enough avoiding the condition of high temperature due to also being continued for some time after the supply of electric power stops and occurring is not
Foot, more appropriate perfusion action can be achieved.
In the conduit system of the present invention, preferably above-mentioned ablation catheter has temperature survey mechanism near its front end, and
Above-mentioned control unit is by the output power in regulation power supply portion to generally remain as the temperature measured by the temperature survey mechanism.So
Form, actual output power can be adjusted to generally remain near the front end of ablation catheter the temperature of (near affected part during ablation)
Degree.That is, after being subject to suitably regulation based on the setting electric power of input, output power is supplied.
In the conduit system of the present invention, aforesaid liquid supply unit can be arranged in fluid Supplying apparatus, and will be upper
State power supply unit and above-mentioned control unit is respectively arranged at the fluid Supplying apparatus as in not androgynous supply unit.So form,
Because each device (fluid Supplying apparatus and supply unit) can be separately configured according to behaviour in service, whole system can be improved
The ease of use of system.Or aforesaid liquid supply unit, above-mentioned power supply unit and above-mentioned control unit can be also respectively arranged at together
In one device.So form, whole system can be simplified.
According to the present invention conduit system because from above-mentioned high power state change to above-mentioned low power state when, at this
During conversion in the case where low power state continue for the 1st stand-by time, the above-mentioned 1st is being maintained to treat the action of above-mentioned big flow
Above-mentioned low discharge action is switched to after the machine time, so can avoid occurring the situation of fluid low in electrical power conversion.Cause
This, can carry out appropriate perfusion action in ablation.
Brief description of the drawings
Fig. 1 is the schematic block diagram for being monolithically fabricated example of the conduit system involved by one embodiment of the present invention.
Fig. 2 is the schematic diagram of the detailed configuration example of ablation catheter shown in Fig. 1.
Fig. 3 is the schematic diagram of one of the relation of the flow action of power state and liquid through actual measurement.
Fig. 4 is the flow chart of one of the action for representing conduit system shown in Fig. 1.
The schematic diagram of one of control action when Fig. 5 is flow action conversion.
Other schematic diagram of control action when Fig. 6 is flow action conversion.
Fig. 7 is the schematic block diagram for being monolithically fabricated example of the conduit system involved by the variation of the present invention.
Embodiment
Describe embodiments of the present invention in detail referring to the drawings.Further, explanation is carried out in the following order.
1st, embodiment (example that fluid Supplying apparatus is set with supply unit with not androgynous)
2nd, variation (the setting example for integrating the single device of various functions)
3rd, other variations
<Embodiment>
[being monolithically fabricated]
Fig. 1 is that conduit system (conduit system 5) involved by one embodiment of the present invention is monolithically fabricated showing for example
Meaning block diagram.The conduit system 5 is to treat the system used during patient (this example is patient 9) cardiac arrhythmia etc., possesses ablation and leads
Pipe 1, fluid Supplying apparatus 2, supply unit 3 and to pole plate 4.That is, in the conduit system 5 of present embodiment, liquid supply dress
2 are put to be formed in a manner of not androgynous with supply unit 3.
(ablation catheter 1)
Ablation catheter 1 is to be inserted in the body of patient 9, affected part melted so as to treat the electricity of cardiac arrhythmia etc. by blood vessel
Pole conduit.Ablation catheter 1 also has makes set perfusion with liquid (for example, physiological saline etc.) from front end in such ablation
The filling mechanism of P1 sides outflow (injection).In other words, conduit system 5 is the conduit system with this filling mechanism.
Fig. 2 is the schematic diagram of the configuration example of ablation catheter 1.The ablation catheter 1 has the (conduit of axle 11 as catheter main body
Axle) and be installed on the axle 11 base portion operating portion 12.
Axle 11 is formed by the tubular structure (tubular part) with flexibility, in the axis direction (Z-direction) along its own
The shape of extension.In addition, axle 11, which has along what the axis direction of its own extended, has been internally formed 1 space (lumen, through hole)
So-called single pore structure or so-called more pore structures formed with plural (for example, 4) space.Further, in the inside of axle 11
The region formed by single pore structure also can be both set, the region formed by more pore structures is set again.In such space,
Various fine rules (wire and behaviour's position etc.) (not shown) are inserted with the state of mutually insulated respectively.
In the inside of axle 11, in addition to having the space for making above-mentioned various fine rule insertions, also formed along axis bearing of trend
There is the space for injecting above-mentioned perfusion liquid L.In addition, near the front end P1 of axle 11, it is attached to be provided with measurement front end P1
The mechanism (temperature survey mechanism) of temperature closely (around affected part).Specifically, inserted with as survey in the space inside axle 11
Measure the thermocouple of the temperature sensor of the temperature.Further, the temperature near the front end P1 so measured is as observed temperature information
Tm, supply unit 3 is supplied to by ablation catheter 1.
This axle 11 such as polyolefin, polyamide, polyether-polyamide, polyurethane by being made.In addition, the axis side of axle 11
To length be about 500~1200mm (such as 1170mm), the external diameter (external diameter of X-Y sections) of axle 11 is about 0.6~3mm (examples
Such as 2.0mm).
Near the front end P1 of axle 11, as shown in the enlarged drawing near the front end P1 in Fig. 2, plural electrode (this is provided with
Locate as 3 ring electrodes 111a, 111b, 111c and 1 preceding termination electrode 112).Specifically, near the P1 of front end, ring electrode
111a, 111b, 111c and preceding termination electrode 112 are arranged with the order and with predetermined distance towards the front end of axle 11.In addition, ring-type
Electrode 111a, 111b, 111c are by fixed configurations respectively on the outer peripheral face of axle 11, and on the other hand, preceding termination electrode 112 is matched somebody with somebody by fixation
It is placed in the front end of axle 11.These electrodes are by the complex lead (not shown) that is inserted in the space of above-mentioned axle 11, with operation
Portion 12 electrically connects.In addition, as denoted by the arrows in fig. 2, above-mentioned perfusion liquid L is flowed out near the front end of preceding termination electrode 112.
Such ring electrode 111a, 111b, 111c and preceding termination electrode 112 are respectively by such as aluminium (Al), copper (Cu), stainless
The metal material with good conductivity such as steel (SUS), golden (Au), platinum (Pt) is made.Further, in order that when using ablation catheter 1
Good to the developability of X ray, above-mentioned electrode is preferably made up of platinum or its alloy.In addition, these ring electrodes 111a, 111b,
There is no particular limitation for the external diameter of 111c and preceding termination electrode 112, preferably from about equal with the external diameter of above-mentioned axle 11.
Operating portion 12 is installed on the base portion of axle 11, has handle (handle portion) 121 and swivel plate 122.
Handle 121 is the part caught and (held) by operator (doctor) when using ablation catheter 1.In the handle 121
Inside have the above-mentioned various fine rules extended to inside axle 11.
Swivel plate 122 is the part of the deflection moving operation (swinging operation) nearby deflected into the front end for exercising axle 11.Tool
Say body, herein as denoted by the arrows in fig. 2, the operation for rotating swivel plate 122 along direction of rotation d1 can be carried out.
(fluid Supplying apparatus 2)
Fluid Supplying apparatus 2 is the device that above-mentioned perfusion liquid L is supplied to ablation catheter 1, as shown in figure 1, having liquid
Body supply unit 21.
Liquid supply unit 21 is to be supplied to the liquid L by the flow of control signal CTL2 defineds described hereinafter at any time to disappear
Melt the mechanism of conduit 1.The liquid supply unit 21 including the part such as liquid pump by forming.
(supply unit 3)
Supply unit 3 is (such as by high frequency (RF in ablation to ablation catheter 1 and to the supply electric power of pole plate 4；Radio
Frequency) form output power Pout) and control fluid Supplying apparatus 2 liquid L supply action device.The electricity
Source device 3 is as shown in figure 1, having input unit 31, power supply unit 32, voltage measurement portion 33, current measurement portion 34, control unit 35 and showing
Show portion 36.
Input unit 31 is the portion for inputting the indication signal of various setting values and the set action of instruction described hereinafter
Point.Various setting values will be described in detail later, such as can be enumerated：Set electric power Ps (=output power Pout maximum electricity
Power), threshold value electric power Pth, target temperature Tt, " HIGH " flow action when fluid flow Fh, " LOW " flow action when liquid
Fluid flow Fst, various stand-by times when flow Fl, the action of " Standby " flow etc..These setting values are by supply unit 3
Operator's (such as technician etc.) input.But such as threshold value electric power Pth can not also be inputted by operator, and in product turnout
Deng when set in advance in supply unit 3.In addition, the setting value inputted by input unit 31 is supplied to control unit 35.Further,
In Fig. 1, represented by the use of the setting electric power Ps in these various setting values as representative.Such input unit 31 for example can be with set
Rotating disk and button, touch panel etc. form.
Power supply unit 32 is according to control signal CTL1 described hereinafter, and above-mentioned output power Pout is supplied into ablation catheter
1 and the part to pole plate 4.Such power supply unit 32 is formed using set electric power loop (such as switch voltage-stabilizing loop etc.).Again
Have, if output power Pout is made up of high frequency, its frequency e.g., about 450kHz~550kHz (such as 500kHz).
Voltage measurement portion 33 is the part of the voltage for the output power Pout that measurement (detection) is exported by power supply unit 32 at any time,
Formed using set voltage detection circuit.The voltage (measurement voltage Vm) so measured by voltage measurement portion 33 is output to control
Portion 35 processed.
Current measurement portion 34 is the part for the electric current for measuring the output power Pout exported by power supply unit 32 at any time, using both
Fixed current detection circuit is formed.The electric current (measured current Im) so measured by current measurement portion 34 is output to control unit
35。
Control unit 35 is the whole supply unit 3 of control and carries out the part of set calculation process, such as uses micro electric
Brain etc. is formed.Specifically, control unit 35 has first calculates the actual measurement electric power Pm (electricity with output power Pout described hereinafter
Force value is corresponding) function.In addition, control unit 35 is with the output power Pout's using control signal CTL1 control power supply units 32
The function (power supply control function) of supply action, and utilize the liquid L of control signal CTL2 control liquid supply unit 21
The function (liquid supply control function) of supply action.
First, the computing function for surveying electric power Pm is as described below.That is, control unit 35 is according to being exported by voltage measurement portion 33
The measurement voltage Vm and measured current Im exported by current measurement portion 34 calculates actual measurement electric power Pm at any time.Specifically, control
Portion 35 calculates actual measurement electric power Pm using following formula (1).The actual measurement electric power Pm so calculated by control unit 35 is described later
Liquid supply control function in used, and be output to display part 36 in this instance.
Pm=(Vm × Im) ... (1)
Next, above-mentioned power supply control function is as described below.That is, control unit 35 is according to above-mentioned observed temperature information Tm
Control signal CTL1 is produced, and by the way that control signal CTL1 is exported to power supply unit 32 to adjust (fine adjustment) output power
Pout size.Specifically, axle 11 represented by observed temperature information Tm is made by adjusting output power Pout size
Temperature near the P1 of front end maintains substantially certain (preferably certain), in other words, the temperature is approximately equal to and (is preferably equal to) in advance
The target temperature Tt first set.
In detail, when temperature of the control unit 35 near the P1 of front end is less than target temperature Tt, being controlled makes output electric
Power Pout values increase.On the other hand, when the temperature near the P1 of front end exceedes target temperature Tt, being controlled makes output power
Pout values reduce.So suitably adjusted based on the setting electric power Ps of input, there is provided actual output power Pout.Change
Sentence is talked about, and setting electric power Ps value and the output power Pout (actual measurement electric power Pm) of reality value might not be consistent.
In addition, aforesaid liquid supply control function is as described below.That is, control unit 35 is according to the actual measurement obtained by the above method
Electric power Pm produces control signal CTL2, and by exporting control signal CTL2 to liquid supply unit 21 to control liquid L stream
Amount.
Specifically, control unit 35 is for example shown in Fig. 3, according to actual measurement electric power Pm control liquid L flow (fluid flow
F).That is, the big of electric power Pm and given threshold electric power Pth set in advance (being, for example, 31W (watt)) value is surveyed by comparing
Small (according to comparative result), set the fluid flow F of control signal CTL2 defineds value (the flow action of liquid supply unit 21
Species).In detail, the high power state that control unit 35 is more than threshold value electric power Pth (Pm >=Pth) in actual measurement electric power Pm
When, fluid flow F controls are acted (F=Fh " HIGH " flow acts) into relatively more big flows.On the other hand, surveying
When electric power Pm is the low power state less than threshold value electric power Pth (Pm ＜ Pth), fluid flow F is controlled into relatively little of rill
Amount action (F=Fl (＜ Fh) " LOW " flow action).In addition, later it is described it is set in the case of, fluid flow F is controlled
Small standby flow action (F=Fst (0 ＜ Fst ＜ Fl) " Standby " flow action) is made.Further, above-mentioned Fh, Fl,
The specific example of Fst value can enumerate Fh=30cc, Fl=17cc, Fst=2CC respectively.In addition, (Fig. 4 is will be explained in hereinafter
~6) this liquid supply control function (fluid flow F control action).
Display part 36 is to the part (monitor) of outside output after various information are represented.As the letter for representing object
Breath, such as can enumerate：By the above-mentioned various setting values (setting electric power Ps etc.) inputted of input unit 31, the reality provided by control unit 35
Electric power Pm and the observed temperature information Tm provided by ablation catheter 1 etc. are provided.But it is not limited to this as the information for representing object
A little information, it is also possible to which other information replaces or additional other information.The various displays of such use of display part 36 (such as liquid crystal
Display, CRT (Cathode Ray Tube) displays and organic EL (Electro Luminescence) display etc.) structure
Into.
(to pole plate 4)
As shown in figure 1, it is to be installed in the state of the body surface of patient 9 to be used in ablation to pole plate 4.Disappearing
When melting, this, hereinafter will specifically to this to high frequency conduction between the electrode of pole plate 4 and the ablation catheter 1 being inserted in the body of patient 9
It is bright.
[effect and effect]
(A. elemental motions)
When treating cardiac arrhythmia, the axle 11 of the ablation catheter 1 in the conduit system 5 is inserted into patient's 9 by blood vessel
In vivo.Now, according to operation of the operator to operating portion 12, it is inserted in the shape near the front end P1 of internal axle 11 and for example exists
Change in one direction or both direction.Specifically, if by the finger of operator along rotation as denoted by the arrows in fig. 2
Direction d1 rotates swivel plate 122, then behaviour's position (not shown) in axle 11 is pulled to base portion side.As a result, before axle 11
P1 is held nearby to be bent along direction d2 as illustrated by the arrows in fig. 1.
Now, electric power when melting is supplied by supply unit 3 (power supply unit 32) to such ablation catheter 1 and to pole plate 4
(output power Pout).Therefore, in above-mentioned treatment cardiac arrhythmia, be installed on patient 9 body surface to pole plate 4 with insertion
High frequency leads between the electrode (preceding termination electrode 112 and ring electrode 111a, 111b, 111c) of the ablation catheter 1 in the body of patient 9
Electricity.By such high frequency conduction, the position (disposal part) of the treatment target of patient 9 is optionally melted, and completes the rhythm of the heart
The transdermal therapeutic of uneven grade.
In such ablation, perfusion liquid is supplied to ablation catheter 1 by fluid Supplying apparatus 2 (liquid supply unit 21)
L.In addition, supply unit 3 (control unit 35) controls the liquid L's of such fluid Supplying apparatus 2 using control signal CTL2
Supply acts.Therefore, (arrow in reference picture 2) perfusion liquid is sprayed near the front end of the preceding termination electrode 112 of ablation catheter 1
Body L.As a result, it can avoid damaging and in disposal portion because caused by rising the excessive temperature of disposal part during ablation
Divide attachment thrombus (improvement hypostasis).
If however, excessive to the liquid L of disposal part discharge flow, the temperature of disposal part reduces, it is possible to right
Disposal during treatment produces harmful effect.In addition, if liquid L entrance is excessive in vivo, it is also possible to increases the burden of patient.The opposing party
Face, if the flow of liquid is very few, it is possible to which the improvement of the cooling and hypostasis of disposing part becomes insufficient.Particularly
When electric power in ablation is high, because because excessive ablation easily causes the damage of tissue and produces thrombus, it is above-mentioned to incline
To will increase.Along with the ablation procedure of reality, the value and axle 11 of (actual measurement electric power Pm) as described above, output power Pout
Front end P1 near temperature (observed temperature information Tm) linkage change.Specifically, in order that the temperature is approximately equal to target temperature
Spend Tt and adjust output power Pout value.That is, the value that electric power Pm is surveyed according to treatment situation changes at any time.In view of these because
Element, need to adjust the flow of liquid according to behaviour in service for possessing the conduit system of filling mechanism, so as to realize appropriate filling
Note acts.
(ablation action detailed B.)
Therefore it is laggard with liquid L flow to adjust (control) perfusion in such a way for the conduit system 5 of present embodiment
Row ablation acts.Such ablation will hereafter be acted and be described in detail.Further, below with regard in Fig. 4 explanation, in order to
The control action for being easy to illustrate the output power Pout for being carried out using above-mentioned observed temperature information Tm is omitted.
Fig. 4 is the flow chart of one of the ablation action for representing present embodiment.In ablation action, first with following
Mode starts above-mentioned " Standby " flow action (step S101).That is, by the operator of supply unit 3 using input unit 31 and
The indication signal for starting the action of " Standby " flow is inputted to control unit 35, then control unit 35 controls liquid supply unit 21
Action make " Standby " flow action start.Therefore, to disposal near the front end of the preceding termination electrode 112 of ablation catheter 1
Part discharge fluid flow F=Fst microperfusion liquid L.
Then, the setting electric power Ps and target temperature Tt during ablation are inputted to input unit 31 by the operator of supply unit 3,
Then these numerical value are provided to control unit 35 to complete setting value (step S102).Then, input unit is utilized by operator
31 setting (instruction) ablations (ablation action) start (step S103).That is, by input unit 31 and defeated to control unit 35
Enter the indication signal for starting ablation.
Now control unit 35 receives to make this preferably only in the case of after judging that the action of " Standby " flow starts
Melt the indication signal started.Before being judged as that the action of " Standby " flow starts conversely speaking, even if input starts ablation
Indication signal, control unit 35 will not also export to power supply unit 32 make the control signal CTL1 that ablation starts.Therefore, opened in ablation
(for example, space in) for working fluid L hydraulically full L before beginning, can be made in ablation catheter 1.As a result, it can avoid for example
Blood flows into inside from the fore-end (for example, liquid L tap hole) of ablation catheter 1, and thrombus is by inside (for example, above-mentioned sky
In gap) block danger.
(action of " LOW " flow)
After such indication signal is received, control unit 35 will be controlled to start liquid flow as described above first
Measure the relatively little of low discharge actions of F (F=Fl " LOW " flow action) (step S104).Therefore, from the front end of ablation catheter 1
The front end of electrode 112 is nearby to disposal part discharge fluid flow F=Fl liquid L.
After stand-by time when then, since acting such " LOW " flow and by set ablation, by electricity
Source portion 32 starts to supply output power Pout (such as high frequency output) (step S105) to ablation catheter 1 and to pole plate 4.Therefore such as
Principles described above, start the ablation of the disposal part of " LOW " flow action.Herein, stand-by time when ablation starts is preferred
About 1~10 second, it was 5 seconds such as to enumerate a suitable example.
In this way, control unit 35 by with make " Standby " flow action switch to " LOW " flow action after, just start
The mode of the supply action of output power Pout during the ablation of power supply unit 32 is controlled, and can advantage is obtained that.That is, because
In general, the supply of liquid is more more time-consuming than power supply compared with electric power, so when can avoid due to such supply
Between difference and the situation of fluid low occurs, realize more appropriate perfusion action.
Then, by voltage measurement portion 33, current measurement portion 34 and control unit 35, carry out above-mentioned measurement voltage Vm and
Measured current Im measurement and calculated using the actual measurement electric power Pm of above-mentioned formula (1), carry out actual measurement electric power Pm measurement
(step S106).
Next, control unit 35 is by the size of the actual measurement electric power Pm more so obtained and threshold value electric power Pth value.Specifically
Ground says, in this example, judge actual measurement electric power Pm whether be more than threshold value electric power Pth (Pm >=Pth) value (step S107).
Now, if it is determined that being Pm ＜ Pth (step S107：N, during low power state), control unit 35 will enter as described above
Row control is acted (F=Fl " LOW " flow acts) (step S108) with continuing the relatively little of low discharges of fluid flow F.
Then, control unit 35, which will determine that whether the operator of supply unit 3 have input by input unit 31, makes output power
The indication signal (step S109) that Pout output stops.Now, if judging to have input the indication signal (step that output stops
S109：Y), thus the control signal CTL1 by exporting the instruction to power supply unit 32 is stopped output power Pout by control unit 35
The supply (step S110) of (high frequency output).Then, from the supply for stopping output power Pout and by set power supply
After stand-by time (the 2nd stand-by time) during stopping, control unit 35, which is just controlled, makes " LOW " flow action conversion extremely
" Standby " flow acts (step S111), completes the whole ablation action shown in Fig. 4.Herein, treated when power supply stops
Preferably from about 1~5 second machine time, it is 2 seconds such as to enumerate a suitable example.
In this way, when the power supply (output power Pout supply) when control unit 35 makes ablation stops, it is defeated from stopping
Reconvert to " Standby " flow moves after going out electric power Pout supply action and stand-by time when power supply stops
Make, can advantage is obtained that.That is, can avoid due to output power Pout supply stopping after disposal part also continue one
The condition of high temperature of section time and cooling deficiency that the perfusion that occurs is carried out with liquid L, can be achieved more appropriate perfusion action.
If in addition, judge without indication signal (the step S109 for inputting above-mentioned output stopping：N), then step is returned to
S106, carry out surveying electric power Pm measurement again.
(action of " HIGH " flow)
In addition, in above-mentioned steps S107, if it is determined that being Pm >=Pth (step S107：Y, during high power state), control unit
35 will be controlled with from present " LOW " flow act to fluid flow F it is relatively more big flow action (F=Fh's
" HIGH " flow acts) conversion (step S112).Thus, by near the front end of the preceding termination electrode 112 of ablation catheter 1 to disposal
Part discharge fluid flow F=Fh liquid L.Therefore, principle described herein above, high power state and " HIGH " flow can be carried out
The ablation of the disposal part of action.
Now as shown in figure 5, this actual measurement electric power Pm from low power state change paramount power state when, it is and described hereinafter
Changed from high power state to different during low power state, control unit 35 will make the action of " LOW " flow rapidly (after being not to wait for
Stand-by time process when set flow action described in text switches) switch to the action of " HIGH " flow.So because can
The action of " HIGH " flow is switched to immediately, so when changing paramount power state from low power state, can avoid that liquid occurs
The very few situation (situation of fluid low) of flow.
Then, in voltage measurement portion 33, current measurement portion 34 and control unit 35, carry out surveying electric power Pm measurement again
(step S113).Then, control unit 35 judge to survey again electric power Pm whether be more than threshold value electric power Pth (Pm >=Pth) value
(step S114).
If it is determined that it is Pm >=Pth (step S114：Y, during high power state), control unit 35, which is controlled, makes " HIGH " flow
Action continues (step S115).Then, then control unit 35 will be in the same manner as above-mentioned steps S109, and judging whether have input makes
The indication signal (step S116) that output power Pout output stops.Now, if being judged as having have input the finger that output stops
Show signal (step S116：Y), control unit 35 stops output electricity by the control signal CTL1 to the output of power supply unit 32 instruction
Power Pout (high frequency output) supply (step S117).Then, from stop output power Pout supply and have passed through above-mentioned
After stand-by time when power supply stops, control unit 35 is controlled with from " HIGH " flow action conversion to " Standby "
Flow acts (step S118), completes the whole ablation action shown in Fig. 4.
So under the situation of progress " HIGH " flow action, when control unit 35 stops output power Pout supply
When, also from reconvert after the supply and stand-by time when power supply stops for stopping output power Pout to
" Standby " flow acts.Therefore, the advantages of identical when being acted with above-mentioned " LOW " flow can be obtained.
If in addition, it is judged as not inputting indication signal (the step S116 that above-mentioned output stops：N), then step is returned to
S113, carry out surveying electric power Pm measurement again.
In addition, in above-mentioned steps S114, if it is determined that being Pm ＜ Pth (step S114：N, during low power state), then control
The whether lasting given time set in advance of (Pm ＜ Pth) state (low power state) is somebody's turn to do in the judgement of portion 35 processed, and (set flow moves
Stand-by time, the 1st stand-by time when making to switch) (step S119).If treated when being judged as not yet continuing flow action switching
Machine time (step S119：N), then to above-mentioned steps S115, control unit 35, which is controlled, continues the action of " HIGH " flow for conversion.
Herein, stand-by time during flow action switching preferably from about 1~10 second, it is 5 seconds such as to enumerate a suitable example.
On the other hand, if being judged as continuing stand-by time (step S119 when flow action switches：Y), then control
Portion 35 is controlled to switch to " LOW " flow action (step S120) from present " HIGH " flow action.Therefore, will be from disappearing
Melt the front end of the preceding termination electrode 112 of conduit 1 nearby to disposal part discharge fluid flow F=Fl liquid L.Further, return later
Above-mentioned steps S106 is returned to, carries out surveying electric power Pm measurement again..
Herein as shown in fig. 6, this actual measurement electric power Pm from high power state change to low power state when, with above-mentioned from low
Difference when power state changes paramount power state, the flow that control unit 35 will control liquid L in the following manner act.That is, control
Portion 35 processed, will in the case of the stand-by time when low power state continue for above-mentioned flow action switching in the conversion
The action of " HIGH " flow switches to the action of " LOW " flow after the stand-by time when having maintained flow action switching.Change sentence
Talk about, after the stand-by time when waiting for such flow action switching, " LOW " stream is switched to from the action of " HIGH " flow
Amount acts.Therefore, when being changed from high power state to low power state, the very few situation of the flow that liquid occurs can be avoided
(situation of fluid low).
Specifically, because with aforesaid liquid flow F when excessive risk (disposal part temperature reduce, to treatment when
Disposal produce harmful effect etc.) compare, risk (the disposal cooling of part and changing for hypostasis when fluid flow F is very few
Kind effect becomes insufficient) big (problem is more deep), so taking above-mentioned control.That is, in view of so risk magnitude relationship,
Although actual measurement electric power Pm state keeps one section of fluid flow F relatively more when being changed during, in order to not make liquid
Oversize during flow F is relatively more, after the stand-by time when have passed through flow action switching, just switching over makes liquid flow
Amount F becomes relatively few.
Further, as shown in a dotted line waveform and "×" symbol in Fig. 6, even being changed from high power state to low electricity
During power state, in the case of the stand-by time in the conversion when low power state not yet continues flow action switching (quite
In step S119：N), then following situation is become.I.e., in such a case, control unit 35 will be without from " HIGH " flow
Action switches to " LOW " flow action (continuing the action of " HIGH " flow).Therefore, as shown in the example in Fig. 6, even if actual measurement electricity
Power Pm value changes over time the variation up and down near threshold value electric power Pth, can also realize appropriate perfusion action.
In above-mentioned present embodiment, because control unit 35 is controlled as follows：Electric power Pm is surveyed from low power state to turn
When shifting to high power state, the action of " HIGH " flow is rapidly switched to from the action of " LOW " flow；On the other hand, from high electric power
During State Transferring to low power state, stand-by time when flow action switches is continue in low power state in the conversion
In the case of, switch to " LOW " stream after the stand-by time when the action of " HIGH " flow is being maintained into flow action switching
Amount acts, so the situation of fluid low can be avoided occurring in electrical power conversion.Therefore, it is possible to carry out appropriate filling in ablation
Note acts.
In addition, control unit 35 by adjusting output power Pout because made by the institute of temperature survey mechanism in ablation catheter 1
The temperature measured generally remains certain, so following effect can be obtained.That is, can be subject to based on the setting electric power Ps of input
After appropriate regulation, actual output power Pout is supplied.
Furtherly, being capable of basis because fluid Supplying apparatus 2 is formed with supply unit 3 in a manner of not androgynous
Each device is separately configured in behaviour in service, improves the ease of use of whole conduit system 5.Specifically, it is as shown in figure 1, logical
Cross and configure fluid Supplying apparatus 2 in relative patient 9 more nearby, so connect the liquid of fluid Supplying apparatus 2 and ablation catheter 1
Supply pipe can shorten, and doctor also easily operates.In addition, at the same time, by the way that supply unit 3 is configured in relative patient 9
Remotely, such technician easily operates.So each device can be configured according to behaviour in service.
<Variation>
Then, the variation of above-mentioned embodiment is illustrated.Further, pair identical with the inscape in embodiment
Part assign identical symbol, and suitably omit the description.
Fig. 7 is that conduit system (conduit system 5A) involved by the variation of above-mentioned embodiment is monolithically fabricated showing for example
Meaning block diagram.The conduit system 5A of this variation is also the system used when treating cardiac arrhythmia of patient 9 etc., possesses ablation and leads
Pipe 1, control device 6 and to pole plate 4.
Control device 6 is using the fluid Supplying apparatus 2 illustrated by above-mentioned embodiment and the integration of supply unit 3 as single
The device that one equipment is formed, there is each part square frame contained by fluid Supplying apparatus 2 and supply unit 3.That is, control device 6 has
Liquid supply unit 21, input unit 31, power supply unit 32, voltage measurement portion 33, current measurement portion 34, control unit 35 and display part 36.
The conduit system 5A of this such variation is different from the conduit system 5 of above-mentioned embodiment, fluid Supplying apparatus 2 and
The various functions of supply unit 3 are integrated in one and formed as single device (control device 6).In other words, liquid supply unit 21,
Input unit 31, power supply unit 32, voltage measurement portion 33, current measurement portion 34, control unit 35 and display part 36 are respectively set at together
One device is in control device 6.
This variation so formed can substantially obtain by with the effect of above-mentioned embodiment identical and it is caused same
The effect of sample.That is, it can avoid occurring in electrical power conversion the situation of fluid low, appropriate perfusion can be carried out in ablation and moved
Make.
In addition, particularly the various functions of fluid Supplying apparatus 2 and supply unit 3 are integrated in one in this variation
Formed as single device (control device 6), whole conduit system 5A composition can be simplified.
<Other variations>
Although above by embodiment is enumerated and variation illustrates the present invention, the present invention is not limited to these realities
Mode etc. is applied, various modifications can be carried out.
For example, each layer illustrated in the above-described embodiment and material of each part etc. do not limit, it is also possible to other
Material.In addition, in the above-described embodiment, although specifically enumerating the composition of ablation catheter 1 (axle 11) and being illustrated,
It it is not absolutely required to that there are whole parts, also can further have miscellaneous part in addition.Specifically, for example, in axle 11
Portion, as tilting member, it may also set up the leaf spring that can be deformed on bending direction.In addition, composition (the ring of the electrode on axle 11
The configuration of shape electrode and preceding termination electrode, shape, quantity etc.) it is not limited to the example in above-mentioned embodiment etc..
In addition, in above-mentioned embodiment etc., although the shape enumerated near the front end P1 of axle 11 can be according to operating portion 12
The ablation catheter type that changes in one direction of operation and be illustrated, but be not restricted to that this.That is, the present invention can
It is applicable the ablation catheter that the shape near the front end P1 of such as axle 11 can change in both directions according to the operation of operating portion 12
Type, it will now use complex root behaviour's position.In addition, the shape that the present invention can be also applicable near the front end P1 of axle 11 is consolidated
Fixed ablation catheter type, it need not now grasp position and swivel plate 122.That is, only handle 121 forms operating portion.
Furtherly, in above-mentioned embodiment etc., although the specific side for enumerating fluid Supplying apparatus 2 and supply unit 3
Frame is formed and is illustrated, but it is not absolutely required to all parts square frame illustrated by with all above-mentioned embodiments,
Also can further have miscellaneous part square frame in addition.In addition, as whole conduit system, except illustrated by above-mentioned embodiment etc.
Each device outside can also further have other devices.Specifically, such as in the (fluid Supplying apparatus of liquid supply unit 21
2 or control device 6) on liquid supply line between ablation catheter 1, also can further have repeater during liquid supply.
Further, in above-mentioned embodiment etc., although various processing when ablation acts are described in detail in process for using figure,
But it is not absolutely required to all carry out the various processing illustrated by above-mentioned embodiment etc., it also can be further carried out in addition
He is handled.Specifically, observed temperature information is acted and utilized for " Standby " flow illustrated by above-mentioned embodiment etc.
The control action for the output power Pout that Tm is carried out, can also be according to circumstances at least without a kind of action therein.
Claims (7)
1. a kind of conduit system, wherein, possess：
Ablation catheter, it has filling mechanism；
Power supply unit, electric power when melting is supplied to the ablation catheter；
Liquid supply unit, perfusion liquid is supplied to the ablation catheter；And
Control unit, supply action and the liquid of the liquid supply unit of the electric power of the power supply unit are controlled respectively
Supply acts,
When actual measurement electric power of the control unit in the ablation is high power state more than threshold value electric power, control turns into described
The relatively more big flow action of the flow of liquid；
On the other hand, when the actual measurement electric power is the low power state less than the threshold value electric power, control turns into the liquid
The action of flow relatively little of low discharge,
And when being changed from the low power state to the high power state, rapidly switched to from low discharge action
The big flow action；
On the other hand, when being changed from the high power state to the low power state, in the conversion in the low electric power
In the case that state continue for the 1st stand-by time, big flow action is switched after the 1st stand-by time has been maintained
Acted to the low discharge.
2. the conduit system described in claim 1, wherein, the control unit is only in small standby of the flow for judging the liquid
In the case that flow action starts afterwards, receive the indication signal for starting the ablation.
3. the conduit system described in claim 2, wherein, the control unit in the case where receiving the indication signal,
After the standby flow action switches to the low discharge action, act the supply of the electric power and start.
4. the conduit system described in any one of claims 1 to 3, wherein, the control unit makes the supply of the electric power
When action stops, after the supply action of the electric power stops and after the 2nd stand-by time, make conversion to the stream of the liquid
Measure small standby flow action.
5. the conduit system described in any one of claims 1 to 3, wherein,
The ablation catheter has temperature survey mechanism near its front end,
The control unit adjusts the output power from the power supply unit so that as the temperature measured by the temperature survey mechanism
Generally remain certain.
6. the conduit system described in any one of claims 1 to 3, wherein,
The liquid supply unit is arranged in fluid Supplying apparatus,
And the power supply unit and the control unit are arranged at respectively to be filled with the fluid Supplying apparatus for not androgynous power supply
In putting.
7. the conduit system described in any one of claims 1 to 3, wherein, the liquid supply unit, the power supply unit and institute
Control unit is stated to be arranged at respectively in same device.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-039600 | 2013-02-28 | ||
| JP2013039600A JP5757586B2 (en) | 2013-02-28 | 2013-02-28 | Catheter system |
| PCT/JP2013/075888 WO2014132476A1 (en) | 2013-02-28 | 2013-09-25 | Catheter system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104822335A CN104822335A (en) | 2015-08-05 |
| CN104822335B true CN104822335B (en) | 2017-12-19 |
Family
ID=51427770
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380062501.6A Expired - Fee Related CN104822335B (en) | 2013-02-28 | 2013-09-25 | Conduit system |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JP5757586B2 (en) |
| KR (1) | KR101737253B1 (en) |
| CN (1) | CN104822335B (en) |
| TW (1) | TWI564042B (en) |
| WO (1) | WO2014132476A1 (en) |
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|---|---|---|---|---|
| WO2020174650A1 (en) * | 2019-02-28 | 2020-09-03 | 日本ライフライン株式会社 | Catheter system |
| WO2020174651A1 (en) * | 2019-02-28 | 2020-09-03 | 日本ライフライン株式会社 | Catheter system |
| US11589918B2 (en) * | 2019-04-08 | 2023-02-28 | Biosense Webster (Israel) Ltd. | System and method for temperature control in irrigated ablation |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078377A (en) * | 1992-11-19 | 1993-11-17 | 中国人民解放军第二一三医院 | Program-controlled multi-function eletrocoagulation condensation therapeutic apparatus |
| CN102238920A (en) * | 2008-10-06 | 2011-11-09 | 维兰德.K.沙马 | Method and apparatus for tissue ablation |
| CN102266245A (en) * | 2010-06-04 | 2011-12-07 | 心诺普医疗技术（北京）有限公司 | Perfusion-type radiofrequency ablation catheter |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6953461B2 (en) * | 2002-05-16 | 2005-10-11 | Tissuelink Medical, Inc. | Fluid-assisted medical devices, systems and methods |
| WO2002089686A1 (en) * | 2001-05-10 | 2002-11-14 | Rita Medical Systems, Inc. | Rf tissue ablation apparatus and method |
| US20050033278A1 (en) * | 2001-09-05 | 2005-02-10 | Mcclurken Michael | Fluid assisted medical devices, fluid delivery systems and controllers for such devices, and methods |
| US9629678B2 (en) * | 2008-12-30 | 2017-04-25 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Controlled irrigated catheter ablation systems and methods thereof |
| US8702693B2 (en) * | 2009-02-17 | 2014-04-22 | Boston Scientific Scimed, Inc. | Apparatus and methods for supplying fluid to an electrophysiology apparatus |
| WO2011088387A2 (en) * | 2010-01-15 | 2011-07-21 | Salient Surgical Technologies, Inc. | Electrosurgical devices, electrosurgical unit and methods of use thereof |
| CN102309364B (en) * | 2010-07-01 | 2013-03-27 | 上海导向医疗系统有限公司 | Gas flow control device for assisting radiofrequency ablation and method for implementing cooling by same |
-
2013
- 2013-02-28 JP JP2013039600A patent/JP5757586B2/en active Active
- 2013-09-25 KR KR1020157023084A patent/KR101737253B1/en active IP Right Grant
- 2013-09-25 CN CN201380062501.6A patent/CN104822335B/en not_active Expired - Fee Related
- 2013-09-25 WO PCT/JP2013/075888 patent/WO2014132476A1/en active Application Filing
- 2013-11-19 TW TW102142026A patent/TWI564042B/en not_active IP Right Cessation
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1078377A (en) * | 1992-11-19 | 1993-11-17 | 中国人民解放军第二一三医院 | Program-controlled multi-function eletrocoagulation condensation therapeutic apparatus |
| CN102238920A (en) * | 2008-10-06 | 2011-11-09 | 维兰德.K.沙马 | Method and apparatus for tissue ablation |
| CN102266245A (en) * | 2010-06-04 | 2011-12-07 | 心诺普医疗技术（北京）有限公司 | Perfusion-type radiofrequency ablation catheter |
Also Published As
| Publication number | Publication date |
|---|---|
| KR101737253B1 (en) | 2017-05-17 |
| JP5757586B2 (en) | 2015-07-29 |
| CN104822335A (en) | 2015-08-05 |
| JP2014166237A (en) | 2014-09-11 |
| TWI564042B (en) | 2017-01-01 |
| TW201433324A (en) | 2014-09-01 |
| KR20150113075A (en) | 2015-10-07 |
| WO2014132476A1 (en) | 2014-09-04 |
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