CN105121464B - 用于预防或治疗骨骼生长迟缓病症的可溶性成纤维细胞生长因子受体3(fgr3)多肽 - Google Patents

用于预防或治疗骨骼生长迟缓病症的可溶性成纤维细胞生长因子受体3(fgr3)多肽 Download PDF

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CN105121464B
CN105121464B CN201480005077.6A CN201480005077A CN105121464B CN 105121464 B CN105121464 B CN 105121464B CN 201480005077 A CN201480005077 A CN 201480005077A CN 105121464 B CN105121464 B CN 105121464B
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fgfr3
sfgfr3
polypeptide
treatment
mice
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CN105121464A (zh
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埃尔维雷·古兹
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French Institute Of Health And Medicine
Universite de Toulouse
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Universite Toulouse III Paul Sabatier
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/10—Protein-tyrosine kinases (2.7.10)
    • C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)

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  • General Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201480005077.6A 2013-01-16 2014-01-16 用于预防或治疗骨骼生长迟缓病症的可溶性成纤维细胞生长因子受体3(fgr3)多肽 Expired - Fee Related CN105121464B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
WOPCT/IB2013/001480 2013-01-16
PCT/IB2013/001480 WO2014111744A1 (en) 2013-01-16 2013-01-16 A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders
PCT/EP2014/050800 WO2014111467A1 (en) 2013-01-16 2014-01-16 A soluble fibroblast growth factor receptor 3 (fgr3) polypeptide for use in the prevention or treatment of skeletal growth retardation disorders

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CN105121464A CN105121464A (zh) 2015-12-02
CN105121464B true CN105121464B (zh) 2021-05-07

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KR (3) KR20160002681A (https=)
CN (1) CN105121464B (https=)
AU (2) AU2013373679A1 (https=)
CA (2) CA2898415A1 (https=)
DK (1) DK2945967T3 (https=)
EA (2) EA201591324A1 (https=)
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PE (1) PE20151664A1 (https=)
PL (1) PL2945967T3 (https=)
PT (1) PT2945967T (https=)
SG (2) SG11201505488XA (https=)
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EP3242888B8 (en) 2015-01-07 2021-06-02 Pfizer Inc. Soluble fgfr3 decoys for treating skeletal growth disorders
KR101981774B1 (ko) * 2016-04-25 2019-05-27 장부다 Vr 공간에서 사용자 인터페이스를 제공하는 방법, 디바이스 및 기록매체
MX2018016257A (es) 2016-07-07 2019-11-21 Therachon Sas Polipéptidos del receptor 3 del factor de crecimiento de fibroblastos solubles (sfgfr3) y usos de los mismos.
JP7335247B2 (ja) * 2017-09-20 2023-08-29 ファイザー・インク 可溶性線維芽細胞増殖因子受容体３（ｓＦＧＦＲ３）ポリペプチドを使用した異常内臓脂肪蓄積の処置
CN108410803B (zh) * 2018-03-28 2019-02-05 湖南源品细胞生物科技有限公司 一种诱导脂肪干细胞成软骨分化的培养方法和培养液
CN110272900B (zh) * 2019-04-19 2024-03-26 中国人民解放军陆军军医大学 用于制备骨骼发育异常猪模型的sgRNA及其应用
WO2022106976A1 (en) 2020-11-18 2022-05-27 Pfizer Inc. Stable pharmaceutical formulations of soluble fgfr3 decoys
WO2022254319A1 (en) 2021-06-01 2022-12-08 Pfizer Inc. Cell culture method for producing sfgfr3 polypeptide

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JP6995069B2 (ja) 2022-02-04
CN105121464A (zh) 2015-12-02
SG11201505140XA (en) 2015-07-30
US20150344855A1 (en) 2015-12-03
CA2896978A1 (en) 2014-07-24
US11702642B2 (en) 2023-07-18
HUE049556T2 (hu) 2020-09-28
DK2945967T3 (da) 2020-07-13
EA201591324A1 (ru) 2016-01-29
MX2015009142A (es) 2015-11-06
JP2016506912A (ja) 2016-03-07
CA2898415A1 (en) 2014-07-24
US20150353624A1 (en) 2015-12-10
WO2014111744A1 (en) 2014-07-24
EP2945967A1 (en) 2015-11-25
WO2014111467A1 (en) 2014-07-24
US20200199545A1 (en) 2020-06-25
EA201591055A1 (ru) 2016-04-29
MX2019013857A (es) 2020-01-20
AU2014206844A1 (en) 2015-07-16
EP3736285A1 (en) 2020-11-11
IL239996A0 (en) 2015-08-31
IL239810A0 (en) 2015-08-31
KR102249454B1 (ko) 2021-05-07
PE20151664A1 (es) 2015-11-28
SI2945967T1 (sl) 2020-10-30
JP2019107006A (ja) 2019-07-04
US20210032608A1 (en) 2021-02-04
KR20150122136A (ko) 2015-10-30
KR20210054026A (ko) 2021-05-12
SG11201505488XA (en) 2015-08-28
PT2945967T (pt) 2020-05-28
JP2016506914A (ja) 2016-03-07
PL2945967T3 (pl) 2020-11-16
EP2945967B1 (en) 2020-04-15
MX372787B (es) 2020-07-03
AU2013373679A1 (en) 2015-08-13
US10724014B2 (en) 2020-07-28
US11814654B2 (en) 2023-11-14
KR20160002681A (ko) 2016-01-08
US20210032607A1 (en) 2021-02-04
HK1217959A1 (zh) 2017-01-27
ES2796743T3 (es) 2020-11-30

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