CN105120829B - Cleaning composition in oral cavity - Google Patents
Cleaning composition in oral cavity Download PDFInfo
- Publication number
- CN105120829B CN105120829B CN201480018834.3A CN201480018834A CN105120829B CN 105120829 B CN105120829 B CN 105120829B CN 201480018834 A CN201480018834 A CN 201480018834A CN 105120829 B CN105120829 B CN 105120829B
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- CN
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- Prior art keywords
- sugar
- sugar ester
- food scraps
- ester
- cleaning composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0216—Solid or semisolid forms
- A61K8/022—Powders; Compacted Powders
- A61K8/0225—Granulated powders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/22—Gas releasing
- A61K2800/222—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Cosmetics (AREA)
Abstract
The present invention provides a kind of for keeping clean composition in oral cavity.The present invention provides cleaning composition in a kind of oral cavity containing sodium bicarbonate, acid, emulsifying agent and base material.
Description
Technical field
The present invention relates to cleaning composition in oral cavity.
Background technology
For keeping clean candy, gel, chewing gum etc. in oral cavity commercially to sell.It is known that have with
Chewing gum for the purpose of prevention decayed tooth, the diet product (patent document 1) for the purpose of suppressing halitosis, have removal tongue fur effect
Food (patent document 2) etc..
However, it is not equipped with sufficiently removing the product of the oral cleaning abilities such as swill.
Prior art literature
Patent document
Patent document 1：Japanese Patent Laid-Open 2008-031062 publications
Patent document 2：Japanese Patent Laid-Open 2011-160734 publications
The content of the invention
The technical problems to be solved by the invention
It is an object of the invention to provide one kind can remove swill (food scraps), the mouth with compared with high cleaning power
Intracavitary cleaning composition.
Technical scheme applied to solve the technical problem
The present invention provides Cleasing compositions in a kind of foaminess oral cavity.
Brief description of the drawings
(Fig. 1) shows the result (dry weights of food scraps) of embodiment 2.
(Fig. 2) shows the result (removal amounts of food scraps) of embodiment 2.
(Fig. 3) shows the result (dry weights of food scraps) of embodiment 3.
(Fig. 4) shows the result (removal amounts of food scraps) of embodiment 3.
(Fig. 5) shows the result (dry weights of food scraps) of embodiment 4.
(Fig. 6) shows the result (dry weights of food scraps) of embodiment 4.
(Fig. 7) shows the result (removal amounts of food scraps) of embodiment 4.
(Fig. 8) shows the result (dry weights of food scraps) of embodiment 5.
(Fig. 9) shows the result (removal amounts of food scraps) of embodiment 5.
Embodiment
The present invention provide it is a kind of containing sodium bicarbonate, acid, emulsifying agent, base material oral cavity in cleaning composition.
Cleaning composition is foamed clear in oral cavity to play by sodium bicarbonate and sour interreaction in the oral cavity of the present invention
Clean effect.Sodium bicarbonate is also referred to as sodium acid carbonate or sodium bicarbonate.As long as acid does not have harmful effect then from special live body
Restriction, can enumerate butanedioic acid, malic acid, ascorbic acid, fumaric acid, acetic acid, lactic acid, gluconic acid, tartaric acid, phosphoric acid or
Citric acid etc. is as an example.These acid also serve as acid and play a role.
Emulsifying agent has the effect of the autgmentability for improving foam or continuation, it can thus be assumed that being to clean effect in enhancing oral cavity
The material of fruit.
As the example of emulsifying agent, fatty acid glyceride, sorbitan carboxylic esters, propylene glycol fatty acid can be enumerated
Ester, sucrose fatty ester (sugar ester) etc..
In the oral cavity of the present invention in cleaning composition, preferred emulsifier contains more than one HLB (hydrophile-lipophile balances
It is worth (Hydrophile-Lipophile Balance)) emulsifying agent more than 3, in addition, the blended amount of emulsifying agent is preferably 5
Weight %, below 20 weight %.In addition, so-called HLB is hydrophily, the value of oil loving balance for representing emulsifying agent.HLB takes 0
Value between~20, it is higher closer to 0 lipophile, it is higher closer to 20 hydrophilies.HLB is surveyed by calculating or surveying
It is fixed.As calculating formula, Atlas methods, Griffins methods, Davies methods, method etc. is known on river.In addition, the mixing of emulsifying agent
The HLB value of thing is the weighted average of the HLB value of each component.
Particularly preferably sugar ester (シ ュ ガ ー エ ス テ Le) is used to be used as emulsifying agent in the present invention.So-called sugar ester, refers to sugarcane
The material that sugar and aliphatic acid are combined into by ester bond.
In the present invention, in the case where using occasion of the sugar ester as emulsifying agent, more than one HLB is preferably comprised more than 3
Sugar ester.In addition, as preferable example, it can enumerate and exist containing sugar esters of more than one the HLB less than 5, more than one HLB
More than 5 sugar ester, in addition, as other preferable examples, can enumerate containing sugar esters of more than one the HLB below 3, one
Sugar esters of the HLB of the kind above more than 7, can further enumerate containing HLB value in the sugar ester that the sugar ester and HLB value that are 3 are 7
Any or their mixture.
As the specific example of sugar ester, Mitsubishi-kagaku Foods Corp.'s (ズ plants of formula meetings of Mitsubishi Chemical フ ー can be enumerated
Society) sale S-070, S-170, S-270, S-370, S-570, S-770, S-970, S-1170, S-1570, S-
1670 grade sucrose stearates；The sucrose palmitates such as P-170, P-1570, P-1670；The sucrose miristic acids such as M-1695
Ester；The sucrose oleates such as O-170, O-1570；The Surfhope SE Cosme C 1216s such as L-195, L-595, L-1695；The sugarcanes such as B-370
Sugared behenate；The sucrose erucates such as ER-190, ER-290 and Di-ichi Kogyo Seiyaku Co., Ltd.'s (the first work industry System medicine strain formulas
Commercial firm) sale DK esters SS (DK エ ス テ Le SS), F-160, F-140, F-110, F-90, F-70, F-50, F-
20W, F-10, F-A10E etc., more preferably S-370, S-770 or their mixture.
In addition, the preferred scope of sugar ester blended amount is more than 5 weight %, below 20 weight %.
Base material is powdered or granular raw-food material, raw material cleaning composition in the oral cavity of the present invention
In blended amount, the weight % of about 30 weight %~90 is accounted for, various materials can be used.For example, arabinose, half can be enumerated
Lactose, xylose, glucose, fucose, sorbose, fructose, rhamnose, ribose, N-acetylglucosamine (N- ア セ チ Le
グ Le U サ ミ Application) etc. monosaccharide；Isotrehalose (イ ソ ト レ ハ ロ ー ス), sucrose, trehalulose (ト レ Ha ル ロ ー ス),
The disaccharides such as trehalose (ト レ ハ ロ ー ス), neotrehalose, palatinose, maltose, melibiose, lactulose, lactose；α-ring
Dextrin, beta-cyclodextrin, isomalto-oligosaccharide (isomaltose, Isomaltotriose, panose etc.), oligomeric-N- acetamido glucoses
Sugared (オ リ go-N- ア セ チ Le グ Le U サ ミ Application), galactolipin sucrose (ガ ラ Network ト シ Le ス ク ロ ー ス), galactolipin breast
Sugared (ガ ラ Network ト シ Le ラ ク ト ー ス), Galactopyranosyl (β 1-3) Galactopyranosyl (β 1-4) glucopyranose (ガ
ラ Network ト ピ ラ ノ シ Le (β 1-3) ガ ラ Network ト ピ ラ ノ シ Le (β 1-4) グ Le U ピ ラ ノ ー ス), Galactopyranosyl
(β 1-3) glucopyranose, Galactopyranosyl (β 1-6) Galactopyranosyl (β 1-4) glucopyranose, gala pyranose
Base (β 1-6) glucopyranose, wood oligose (キ シ ロ オ リ go sugar) (xylotriose, xylobiose etc.), gentio (ゲ Application チ オ
オ リ go sugar) (gentiobiose, gentianose, rough gentian tetrose etc.), stachyose, Tang De oligosaccharides (テ ア Application デ オ リ go), aspergillus niger
Oligosaccharides (nigerose etc.), para gold oligosaccharides, fructooligosaccharide (ketose, Nystose etc.), sugarcane fruit furans tetrose, poly- grape
Sugar, maltose-beta-cyclodextrin, Fructus Hordei Germinatus oligose (maltotriose, maltotetraose, maltopentaose, maltose, the sugar of malt seven
Deng), gossypose, soy oligosaccharide, the oligosaccharide kind such as inverted sugar；Hydroxyl isomaltulose, antierythrite, xylitol, glycerine, D-sorbite,
Isomalt (パ ラ チ ニ ッ ト), maltitol, maltotetraose alcohol, maltotriose alcohol, mannitol, lactitol, reduction are different
The sugar alcohols such as Fructus Hordei Germinatus oligose, reduction wood oligose, reduction gentio.
In the oral cavity of the present invention in cleaning composition, in addition to mentioned component, tackifier, sweet tea can also be suitably added
Taste agent, spices, acid, anticaking agent, water etc..
Tackifier are not limited, by way of example, can enumerate pectin, guar gum, xanthans, chitosan, tamarind gum,
More carbohydrates and their derivatives, the other examples such as carrageenan, cellulose, methylcellulose, carboxymethyl cellulose (CMC) can also arrange
Lift gelatin, sodium alginate, casein-sodium, sodium carboxymethyl starch, propylene glycol alginate etc..There is no particular limitation for sweetener,
As an example, can enumerate arabinose, galactolipin, xylose, glucose, fucose, sorbose, fructose, rhamnose, ribose,
The monosaccharides such as isomerization liquid sugar, N-acetylglucosamine；Isotrehalose, sucrose, trehalulose (ト レ Ha ル ロ ー ス), sea
The disaccharides such as algae sugar (ト レ ハ ロ ー ス), neotrehalose, palatinose, maltose, melibiose, lactulose, lactose；α-ring paste
Essence, beta-cyclodextrin, isomalto-oligosaccharide (isomaltose, Isomaltotriose, panose etc.), oligomeric-N- acetamido glucoses
Sugar, galactolipin sucrose, galactolipin lactose, Galactopyranosyl (β 1-3) Galactopyranosyl (β 1-4) glucopyranose, half
Newborn pyranose (β 1-3) glucopyranose, Galactopyranosyl (β 1-6) Galactopyranosyl (β 1-4) glucopyranose,
Galactopyranosyl (β 1-6) glucopyranose, wood oligose (xylotriose, xylobiose etc.), gentio (ゲ Application チ オ オ リ go
Sugar) (gentiobiose, gentianose, rough gentian tetrose etc.), stachyose, Tang De oligosaccharides (テ ア Application デ オ リ go), nigero-oligosaccharide
(nigerose etc.), para gold oligosaccharides, palatinose slurry, fructooligosaccharide (ketose, Nystose etc.), sugarcane fruit furans tetrose,
Polydextrose, maltose-beta-cyclodextrin, Fructus Hordei Germinatus oligose (maltotriose, maltotetraose, maltopentaose, maltose, malt
Seven sugar etc.), gossypose, coupling sugar (カ ッ プ リ Application グ シ ュ ガ ー), soy oligosaccharide, inverted sugar, the oligosaccharide kind such as maltose；Different malt
Sugar alcohol, antierythrite, xylitol, glycerine, D-sorbite, isomalt, maltitol, maltotetraose alcohol, maltotriose
Alcohol, mannitol, lactitol, reduction isomaltulose, reduction wood oligose, reduction gentio, reduction malt sugar, reduction maltosemalt sugar
The sugar alcohols such as sugar；Phlorose based transferase sweetens, and (α-グ Le U シ Le ト ラ Application ス Off ェ ラ ー ゼ handle ス テ ビ to synanthrin
ア), Aspartame, acesulfame potassium, alitame, licorice (glycyrrhizin), three ammonium of glycyrrhizic acid, tripotassium glycyrrhetate,
Trisodium glycyrrhetinate, diammonium glycyrrhizinate, dipotassium glycyrrhizinate, disodium glycyrrhizinate, curculin (Network Le Network リ Application), saccharin, saccharin
Sodium, honey element, Sucralose, stevia rebaudianum (ス テ ビ ア) extract, stevia rebaudianum powder, sucdrol (ズ Le チ Application), Talin (ソ ー マ
チ Application), sweet tea herbal tea extract (テ Application リ ョ ウ チ ャ extracts), Mo Neilin extracts (Na イ ゼ リ ア ベ リ ー extracts), knob
Sweet tea, neohesperidin dihydrochalcone (ネ オ ヘ ス ペ リ ジ Application ジ ヒ De ロ カ Le Us Application), transfructosylase become stevioside
(Off ラ Network ト シ Le ト ラ Application ス Off ェ ラ ー ゼ processing ス テ ビ ア), (Block ラ ジ Le カ Application ゾ ウ take out Brazilian licorice
Go out thing), mysterious berry extract, Fructus Monordicae extract, enzymatic treatment radix glycyrrhizae, the high-intensity sweeteners such as enzyme degraded radix glycyrrhizae.
As the example of spices, the citruses such as orange oil, lemon oil, oil of grapefruit, lime oil, tangerine oil, mandarin oil can be enumerated
The peppermint essence oils such as essential oil class, peppermint oil, spearmint oil, allspice, illiciumverum, sweet basil, bay, cardamom, celery, cloves, meat
Osmanthus, fennel seeds, dill, garlic, parsley, nutmeg, mustard, onion, pimiento, parsley, rosemary, pepper are so known fragrant
Expect essential oil class or oleoresin class (オ レ オ レ ジ Application Class), limonene, linalool, nerol, citronellol, geraniol, lemon
Aldehyde, l-menthol, eugenol, cinnamic acid, anethole, perillaldehyde (ペ リ ラ ア Le デ Ha イ De), vanillic aldehyde, γ-ten carbon
So known individually spices or the conjunction such as alkanoic acid lactone, allyl hexanoate (カ プ ロ Application acid ア リ Le), L- carvols, maltol
Carried out into spices, and by these tangerine oil classes, peppermint essence oils, spices essential oil class, synthetic perfume according to the ratio of target
Mix it is obtained show as mixing citrus (シ ト ラ ス ミ ッ Network ス), mixing peppermint (ミ ッ Network ス ミ Application ト), various fruit etc. it is mixed
Blending material.As the example of anticaking agent, particulate oxide silicon, tricalcium phosphate, calcium silicates, calcium stearate, stearic acid can be enumerated
Magnesium etc..
(embodiment)
Embodiment is as follows.
Embodiment 1
As the example of cleaning composition in oral cavity, manufacture and formed effervescent tablet is formed by table 1.The following institute of preparation method
State.Base material is mixed with guar gum, a part of sugar ester, a part of spices first, average grain diameter is reached as 70 μm using size
~500 μm or so of condition is granulated, and malic acid or sodium bicarbonate as other raw materials are added into the material after granulation, is remained
Remaining sugar ester etc. and mixed, shaped by carrying out tabletting to the mixture so as to finished product.Alternatively, it is also possible to only right
Base material reaches average grain diameter using original dimensions and is granulated as 70 μm~500 μm or so of condition, adds into the base material after granulation
Enter other raw materials and mixed, shaped by carrying out tabletting to the mixture so as to finished product.It is made in the present embodiment
The weight of effervescent tablet be 1.55g, shape is flattened cylindrical shape.
In table 1, the weight % of the ratio of each raw material after the completion of is represented.Add Mitsubishi in various proportions into emulsifying agent
Learn more than one or two kinds of in sugar ester S-170, S-370, S-770 and S-1670 of food Co., Ltd. sale.These
The characteristic of sugar ester is shown in table 2.Base material uses maltitol or D-sorbite.
(table 1)
Table 1
| Material name | (weight %) |
| Base material | 67.2~42.2 |
| Sugar ester | 0~25.0 |
| Tackifier：Guar gum | 0.04 |
| Sweetener：Aspartame | 2.0 |
| Spices | 3.3 |
| Particulate oxide silicon | 1.5 |
| Malic acid | 16.0 |
| Sodium bicarbonate | 10.0 |
| The water of addition | 6.8 |
| After the completion of total amount | 100.0 |
(table 2)
Table 2
Embodiment 2
The comparison of cleaning effect in the oral cavity of the diverse effervescent tablet of sugar ester
Sample
According to the following 4 kinds of tablets of method manufacture of embodiment 1.But base material is all using D-sorbite.
Effervescent tablet S-17010.0% blends product
Effervescent tablet S-37010.0% blends product
Effervescent tablet S-3705.0%, S-7705.0% blend product
Effervescent tablet S-167010.0% blends product
Food scraps removal effect validation test
(not take in tablet as condition)
As usual chew, swallow the Ao Liao of Mei Shanqi Nabiscos Co., Ltd. (ヤ マ ザ キ ナビスコ societies) production
After (オ レ オ) (registration mark) sandwich biscuits, 20ml water is contained in entrance, with 180 beats/min of Frequency Active oral cavity, is carried out
10 seconds gargle.After 10 seconds, gargle is all recycled.8000 × g, the centrifugation of 10 minutes are carried out to gargle,
After being dried under reduced pressure the sediment for eliminating supernatant, weight (being denoted as dry weight A below) is measured.
(to take in tablet as condition)
As usual after chewing, swallowing one piece of Leo difficult to understand, one piece of effervescent tablet is fully chewed, keeps oral cavity 5 seconds motionless, then gulped down
Pharynx.At this time, the number swallowed is once.And then, 20ml water is contained in entrance, with 180 beats/min of Frequency Active oral cavity,
10 seconds gargle.After 10 seconds, gargle is all recycled.8000 × g, the centrifugation of 10 minutes point are carried out to gargle
From, after being dried under reduced pressure the sediment for eliminating supernatant, measure weight (being denoted as dry weight B below).
Experimental result more than, tries to achieve food scraps removal amount according to the following formula.
Food scraps removal amount (mg)=(dry weight A)-(dry weight B)
In addition, food scraps removal rate is tried to achieve according to the following formula.
Food scraps removal rate (%)=(the food scraps removal amount under the conditions of each)/(dry weight A) × 100
As a result
It is accurate for the purpose of influence caused by the removal effect for confirming sugar ester counterpart intracavitary food scraps in the present embodiment
For the effervescent tablet of the sugar ester for the different HLB values for being blended with total 10.0%, food scraps removal effect validation test has been carried out.
Food scraps dry weight when absorbing each effervescent tablet is shown in Fig. 1, and food scraps removal amount is shown in Fig. 2, food scraps removal rate
It is shown in table 3.As a result, S-3705.0%, S-7705.0% that sugar alcohol compositions form, which blend product, shows highest removal amount,
Afterwards, removal amount blends product according to S-167010%, S-37010% blends product, the order of S-17010% blending product is passed
Subtract.Wherein, in 3 kinds of blending product in addition to S-17010% blending product, it was observed that food scraps removal rate is above
80%.
The S-170 minimum as HLB value blends the main reason for product removal amount is relatively low, it is believed that is due to its foaminess
Weaker, foam does not extend to oral cavity entirety；It is short in the intraoral holdup time since its physical property is more crisp.This tendency
It is improved in sugar ester (S-370) of the HLB value more than 3, it is thus identified that S-1670, which blends product, also to be had than S-170 blending product
The food scraps removal amount of higher.In addition, S-370S-770 highest with removal amount blends condition ratio, though S-370 blends product
Right foaminess is strong, but since the quality of foam is coarse, single foam defoaming is fast, and S-1670 blends the quality of the foam of product excessively
Such as butyrous, although the duration of single foam is longer, give the slightly weak impression of the autgmentability of foam (with reference to implementation
Example 6, table 8).Therefore, when removing food scraps, the quality as foam, it is desirable to which it is extended with appropriate defoaming sense
Property the duration property, it is believed that it is combination the advantages of having played two kinds of sugar esters that S-370S-770, which blends product,.
(table 3)
The food scraps removal rate (n=4) of the diverse effervescent tablet of 3 sugar ester of table
Embodiment 3
Cleaning effect in the oral cavity of the different effervescent tablet of sugar ester blended amount
Sample
According to the following 6 kinds of tablets of method manufacture of embodiment 1.But base material is all using D-sorbite.
Effervescent tablet sugar ester does not blend product
Effervescent tablet S-3700.5%, S-7700.5% blend product
Effervescent tablet S-3702.5%, S-7702.5% blend product
Effervescent tablet S-3705.0%, S-7705.0% blend product
Effervescent tablet S-37010.0%, S-77010.0% blend product
Effervescent tablet S-37012.5%, S-77012.5% blend product
Food scraps removal effect validation test
Tested according to the mode identical with " validation test of food scraps removal effect " of embodiment 2.
As a result
In the present embodiment, for the group of food scraps removal effect highest S-370, S-770 in the result of embodiment 2
Close, the blended amount of each sugar ester is divided into several sections between 0%~12.5% and blends tablet, confirms it for food scraps
The influence that removal effect produces.Food scraps dry weight when absorbing each effervescent tablet is shown in Fig. 3, and food scraps removal amount is shown in
Fig. 4, food scraps removal rate are shown in table 4.According to result it has been confirmed that the effervescent tablet for being blended with two kinds of sugar esters each 5.0% is presented
Go out highest removal rate, and sugar ester does not blend product and shows minimum removal rate.For the blended amount of each sugar ester, positioned at 5.0%
Although the 2.5% blending product and 10.0% blending product on both sides are lower with 5.0% blending condition specific removal rate, but it is compared to both sides
0.5% blending product, 12.5% blending product then maintain higher removal rate.The blended amount of sugar ester is 2.5%, 5.0%,
In 10.0% each blending product, it was observed that the numerical value of removal rate has exceeded 80%.
The main reason for product removal rate is relatively low is not blended as sugar ester, it is believed that although being due to be produced by sodium bicarbonate
Foaming, but duration of the extension, bubble almost without bubble (with reference to embodiment 6, table 8).In addition, for two kinds of sugar
The blending product of ester each 0.5%, the blended amount of sugar ester is also insufficient, has confirmed identical tendency.For two kinds of sugar esters each 12.5%
Blending product, the blending condition ratio with two kinds of sugar esters each 5.0%, physical property is very crisp, feels that holdup time of the tablet in mouth is short.Separately
Outside, for the feature of bubble, condition ratio is blended with 5.0%, it is believed that since expansion rate is slow, the duration is slightly worse, therefore
Removal rate is lower.
(table 4)
The food scraps removal rate (n=4) of the different effervescent tablet of 4 sugar ester blended amount of table
| S-370 blending rate (%) | - | 0.5% | 2.5% | 5.0% | 10.0% | 12.5% |
| S-770 blending rate (%) | - | 0.5% | 2.5% | 5.0% | 10.0% | 12.5% |
| Food scraps removal rate (%) | 71.9 | 75.1 | 81.2 | 87.1 | 82.8 | 74.8 |
Embodiment 4
Cleaning effect in the oral cavity of the different effervescent tablet of base material
Sample
According to the following 3 kinds of tablets of method manufacture of embodiment 1.
Effervescent tablet S-37010.0% blends product (using glucose as base material)
Effervescent tablet S-37010.0% blends product (using D-sorbite as base material)
Effervescent tablet S-37010.0% blends product (using maltitol as base material)
Food scraps removal effect validation test
Tested according to the mode identical with " validation test of food scraps removal effect " of embodiment 2.
As a result
The effervescent tablet using D-sorbite as base material is used to be tested in embodiment 2,3.In the present embodiment, with
The effervescent tablet that 10.0% sugar alcohol S-370 is blended confirms that the species for changing base material is produced for food scraps removal effect as object
Raw influence.Food scraps dry weight when absorbing each effervescent tablet is shown in Fig. 5, Fig. 6, and food scraps removal amount is shown in Fig. 7, food
Thing detritus removal rate is shown in table 5.By result, for the removal rate of food scraps, D-sorbite is shown as highest
81.5%, then maltitol base material be shown as 80.1%, glucose base material is shown as 75.0%.
For the removal rate of food scraps, the difference of this used 3 kinds of tablet is up to 6.5% (sorbose alcohol radical
The difference of material and glucose base material).In embodiment 2, embodiment 3,14.7%, 15.2% is followed successively by from maximum removal rate difference
It was determined that the difference of food scraps removal rate is smaller than conventional result in the present embodiment.Therefore, for being blended with sugar ester
Effervescent tablet, it is believed that base material does not have so big for the influence that food scraps removal effect produces.But if by sense organ
The result of evaluation accounts for, then since the effervescent tablet mouthfeel of glucose base material is crisp (with reference to embodiment 6, table 8), considers thing
Property aspect when can consider that D-sorbite, maltitol are the base materials more suitable for tablet.
(table 5)
The food scraps removal rate (n=4) of the different effervescent tablet of 5 base material of table
| Base material | Glucose | D-sorbite | Maltitol |
| Food scraps removal rate (%) | 75.0 | 81.5 | 80.1 |
Embodiment 5
Cleaning effect in the oral cavity of effervescent tablet
Sample
Following tablet is manufactured according to the method for embodiment 1.
S-3705.0%, S-7705.0% blend product, (using maltitol as base material).
Food scraps removal effect validation test
Tested according to the same manner as in Example 2.
As a result
Confirm the influence produced for food scraps removal effect using according to effervescent tablet made of embodiment 1.Food
Detritus dry weight is shown in Fig. 8, and food scraps removal amount is shown in Fig. 9, and food scraps removal rate is shown in Fig. 6.As a result food is understood
The value of detritus removal rate is 80.4%.The food of product is blended from the S-37010.0% in the same table 5 using maltitol base material
Thing detritus removal rate can obtain following enlightenment for 80.1%：Although difference is small, with using D-sorbite base material in table 3
Occasion it is identical, using maltitol base material occasion under, with S-37010.0% blend condition ratio, S-3705.0%,
The removal effect that S-7705.0% blends product may higher.In addition, if it is conceived to S-3705.0%, S-7705.0%
Blending product, then in table 3 using D-sorbite base material when removal rate 87.1% be higher than table 6 in using maltitol base material when
Removal rate 80.4%, so as to give the enlightenment identical with table 5, i.e. even if the species of sugar ester is different, use sorbose alcohol radical
The occasion of material may also be than showing higher removal effect using the occasion of maltitol base material.
(table 6)
The food scraps removal rate (n=4) of the effervescent tablet of 6 embodiment 5 of table
Embodiment 6
The sensory evaluation experiment of effervescent tablet
4 people panels of expert carry out sensory evaluation to the effervescent tablet used in above-described embodiment.In sensory evaluation, pass through nozzle
Chew and eat each tablet, to " quality of foam ", " autgmentability of foam ", " the lasting sense of foam ", " mouthfeel " 4 projects with 1
10 grades of~10 are evaluated.It is as shown in table 7 for 4 projects of evaluation, the standard of score.The result of sensory evaluation such as table 8
It is shown.
(table 7)
Table 7
| The quality of foam | 1 (excessively coarse, or as excessively dense such as butyrous)~10 (appropriate defoaming sense) |
| The autgmentability of foam | 1 (autgmentability is poor)~10 (autgmentability is very good) |
| The lasting sense of foam | 1 (not having frothy lasting sense, or foam excessive residual)~10 (appropriate lasting sense) |
| Mouthfeel | 1 (excessively crisp, or really up to the mark)~10 (appropriate hardness) |
(table 8)
The Analyses Methods for Sensory Evaluation Results of 8 effervescent tablet of table
Embodiment 7
The effervescent tablet of composition of the manufacture with table 9.After the completion of total amount represent raw material is mixed in engineering is granulated
And dried result has reached 100.0 weight %.The effervescent tablet shows significant food scraps when being held in mouth
Removal effect.
(table 9)
Table 9
| Material name | (weight %) |
| Maltitol powder | 57.2 |
| Sugar ester S-370 | 5.0 |
| Sugar ester S-770 | 5.0 |
| Guar gum | 0.04 |
| Acesulfame potassium | 2.0 |
| Spices | 1.8 |
| Tricalcium phosphate | 1.5 |
| Fumaric acid | 16.0 |
| Sodium bicarbonate | 10.0 |
| The water of addition | 6.8 |
| After the completion of total amount | 100.0 |
Embodiment 8
The effervescent tablet of composition of the manufacture with table 10.After the completion of total amount represent raw material is mixed in engineering is granulated
And dried result has reached 100.0 weight %.The effervescent tablet of table 10 shows significant food when being held in mouth
Detritus removal effect.
(table 10)
Table 10
| Material name | (weight %) |
| D-sorbite | 60.3 |
| Sugar ester S-370 | 5.0 |
| Sugar ester S-1670 | 5.0 |
| Arabic gum | 0.04 |
| Sucralose | 1.0 |
| Spices | 1.7 |
| Particulate oxide silicon | 1.5 |
| Citric acid | 14.0 |
| Sodium bicarbonate | 10.0 |
| The water of addition | 6.8 |
| After the completion of total amount | 100.0 |
The summary of embodiment
Under using a kind of occasion of sugar ester, by blending sugar ester of the HLB value more than 3, significant oral cavity can be obtained
Interior swill removal effect.
Under the occasion using more than at least two sugar esters, if the sugar ester and one by more than one HLB value below 3
Sugar ester combination of the HLB value of the kind above more than 7 blends, can compared with blending a kind of condition of sugar ester of HLB value more than 3
To obtain higher food scraps removal effect.
In the range of the blended amount of sugar ester is 5%~20% in effervescent tablet total amount, shows and do not blend product higher than sugar ester
Food scraps removal effect, particularly 10% blending product show highest effect.
The effervescent tablet for having blended sugar ester is not easily susceptible to the influence of base material for the removal effect of swill in oral cavity, any
Kind base material can all maintain food scraps removal effect.Especially when considering food scraps removal effect and physical property, preferably using mountain
Pears sugar alcohol or maltitol are as base material.
This application claims the excellent of the Japanese patent application No. 2013-073533 to be filed an application based on March 29th, 2013
First weigh, quote a part of its content as the application.
Claims (7)
1. a kind of oral cleaning composition, contains sodium bicarbonate, acid, sugar ester and base material；
The sugar ester is the material that sucrose and aliphatic acid are combined into by ester bond, the sugar containing at least one HLB more than 3
Ester；
The content of the sugar ester is more than 5 weight % and below 20 weight % in oral cleaning composition.
2. oral cleaning composition as claimed in claim 1, it is characterised in that as sugar ester, contain more than one HLB
The sugar ester of sugar ester, more than one HLB more than 5 less than 5.
3. oral cleaning composition as claimed in claim 1, it is characterised in that as sugar ester, contain more than one HLB
The sugar ester of sugar ester, more than one HLB more than 7 below 3.
4. oral cleaning composition as claimed in claim 1, it is characterised in that as sugar ester, contain the sugar that HLB value is 3
Ester and the sugar ester that at least one HLB value is 7.
5. oral cleaning composition as claimed in claim 1, it is characterised in that acid is malic acid.
6. oral cleaning composition as claimed in claim 1, it is characterised in that base material is maltitol or sorbose
Alcohol.
7. a kind of method for cleaning oral cavity, utilizes the oral cleaning composition any one of claim 1 to 6.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013-073533 | 2013-03-29 | ||
| JP2013073533A JP6266891B2 (en) | 2013-03-29 | 2013-03-29 | Oral cleaning composition |
| PCT/JP2014/001629 WO2014156096A1 (en) | 2013-03-29 | 2014-03-20 | Composition for cleaning inside oral cavity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105120829A CN105120829A (en) | 2015-12-02 |
| CN105120829B true CN105120829B (en) | 2018-05-08 |
Family
ID=51623110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480018834.3A Expired - Fee Related CN105120829B (en) | 2013-03-29 | 2014-03-20 | Cleaning composition in oral cavity |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JP6266891B2 (en) |
| KR (1) | KR102191355B1 (en) |
| CN (1) | CN105120829B (en) |
| HK (1) | HK1216990A1 (en) |
| TW (1) | TWI610688B (en) |
| WO (1) | WO2014156096A1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546535A (en) * | 2015-01-06 | 2015-04-29 | 韩俊峰 | Active lytic enzyme for improving effects of toothpaste, detergent and cleaning agent |
| US11351103B2 (en) | 2016-11-18 | 2022-06-07 | Johnson & Johnson Consumer Inc. | Method of providing oral care benefits |
| JP6840849B2 (en) * | 2016-11-18 | 2021-03-10 | フェルティン ファルマ アー／エス | Tablets containing separate binders and erythritol |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101374503A (en) * | 2006-01-26 | 2009-02-25 | 东亚药品株式会社 | Quickly disintegrating tablet produced by direct dry-tabletting |
| CN101496591A (en) * | 2008-01-29 | 2009-08-05 | 北京康必得药业有限公司 | Effervescent tablet containing ginger component |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5314611B2 (en) * | 1972-05-13 | 1978-05-18 | ||
| JPH08157356A (en) * | 1994-12-06 | 1996-06-18 | Kao Corp | Tablet for oral cavity use |
| JPH097421A (en) * | 1995-06-16 | 1997-01-10 | Nippon Kayaku Co Ltd | Conductor paste composition and its hardened material |
| JP3706204B2 (en) * | 1996-08-09 | 2005-10-12 | 花王株式会社 | Oral solid formulation |
| JPH11152217A (en) * | 1997-11-19 | 1999-06-08 | Kao Corp | Composition for oral cavity |
| US6428770B1 (en) * | 1997-12-03 | 2002-08-06 | Kao Corporation | Solid preparation for oral hygiene |
| JP3818789B2 (en) * | 1999-02-18 | 2006-09-06 | 三菱化学フーズ株式会社 | Easily disintegrating tablets |
| JP2002308747A (en) * | 2001-04-10 | 2002-10-23 | Lion Corp | Foamable solid composition for oral cavity |
| JP2003113060A (en) * | 2001-10-02 | 2003-04-18 | Lion Corp | Sugar-coated material containing foaming component |
| JP5089100B2 (en) | 2006-07-27 | 2012-12-05 | 株式会社ロッテ | Methioninase inhibitor, composition containing the same, and food and drink |
| JP2011160734A (en) | 2010-02-10 | 2011-08-25 | Lotte Co Ltd | Food product having tongue plaque eliminating effect |
-
2013
- 2013-03-29 JP JP2013073533A patent/JP6266891B2/en active Active
-
2014
- 2014-03-20 WO PCT/JP2014/001629 patent/WO2014156096A1/en active Application Filing
- 2014-03-20 KR KR1020157031134A patent/KR102191355B1/en active IP Right Grant
- 2014-03-20 CN CN201480018834.3A patent/CN105120829B/en not_active Expired - Fee Related
- 2014-03-27 TW TW103111481A patent/TWI610688B/en active
-
2016
- 2016-04-28 HK HK16104909.4A patent/HK1216990A1/en not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101374503A (en) * | 2006-01-26 | 2009-02-25 | 东亚药品株式会社 | Quickly disintegrating tablet produced by direct dry-tabletting |
| CN101496591A (en) * | 2008-01-29 | 2009-08-05 | 北京康必得药业有限公司 | Effervescent tablet containing ginger component |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014156096A1 (en) | 2014-10-02 |
| JP6266891B2 (en) | 2018-01-24 |
| HK1216990A1 (en) | 2016-12-16 |
| KR20150138312A (en) | 2015-12-09 |
| CN105120829A (en) | 2015-12-02 |
| KR102191355B1 (en) | 2020-12-15 |
| JP2014196278A (en) | 2014-10-16 |
| TW201532618A (en) | 2015-09-01 |
| TWI610688B (en) | 2018-01-11 |
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