WO2014057637A1 - Composition for alleviating hunger sensation - Google Patents
Composition for alleviating hunger sensation Download PDFInfo
- Publication number
- WO2014057637A1 WO2014057637A1 PCT/JP2013/005922 JP2013005922W WO2014057637A1 WO 2014057637 A1 WO2014057637 A1 WO 2014057637A1 JP 2013005922 W JP2013005922 W JP 2013005922W WO 2014057637 A1 WO2014057637 A1 WO 2014057637A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- glucomannan
- composition
- gum
- feeling
- chewing
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 235000003642 hunger Nutrition 0.000 title claims abstract description 13
- 230000035807 sensation Effects 0.000 title abstract 5
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims abstract description 75
- 229920002581 Glucomannan Polymers 0.000 claims abstract description 75
- 229940046240 glucomannan Drugs 0.000 claims abstract description 75
- 210000002784 stomach Anatomy 0.000 abstract description 18
- 230000001055 chewing effect Effects 0.000 abstract description 14
- 210000003296 saliva Anatomy 0.000 abstract description 9
- 235000019577 caloric intake Nutrition 0.000 abstract description 3
- 239000000243 solution Substances 0.000 description 31
- 238000011156 evaluation Methods 0.000 description 20
- 235000010449 maltitol Nutrition 0.000 description 12
- 239000000845 maltitol Substances 0.000 description 12
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 12
- 229940035436 maltitol Drugs 0.000 description 12
- 229940112822 chewing gum Drugs 0.000 description 9
- 235000015218 chewing gum Nutrition 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000000284 extract Substances 0.000 description 7
- 229920001542 oligosaccharide Polymers 0.000 description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000000341 volatile oil Substances 0.000 description 6
- 235000020805 dietary restrictions Nutrition 0.000 description 5
- 235000003599 food sweetener Nutrition 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000003765 sweetening agent Substances 0.000 description 5
- 239000006188 syrup Substances 0.000 description 5
- 235000020357 syrup Nutrition 0.000 description 5
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 4
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 4
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 4
- 150000002482 oligosaccharides Chemical class 0.000 description 4
- HELXLJCILKEWJH-NCGAPWICSA-N rebaudioside A Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HELXLJCILKEWJH-NCGAPWICSA-N 0.000 description 4
- PVXPPJIGRGXGCY-DJHAAKORSA-N 6-O-alpha-D-glucopyranosyl-alpha-D-fructofuranose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@](O)(CO)O1 PVXPPJIGRGXGCY-DJHAAKORSA-N 0.000 description 3
- 244000215068 Acacia senegal Species 0.000 description 3
- 241000207199 Citrus Species 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 3
- 235000006679 Mentha X verticillata Nutrition 0.000 description 3
- 235000002899 Mentha suaveolens Nutrition 0.000 description 3
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 3
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 3
- 235000011613 Pinus brutia Nutrition 0.000 description 3
- 241000018646 Pinus brutia Species 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229920002472 Starch Polymers 0.000 description 3
- 244000228451 Stevia rebaudiana Species 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 235000020971 citrus fruits Nutrition 0.000 description 3
- 150000002016 disaccharides Chemical class 0.000 description 3
- 239000000796 flavoring agent Substances 0.000 description 3
- 235000019634 flavors Nutrition 0.000 description 3
- 230000037406 food intake Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 3
- 239000008123 high-intensity sweetener Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 150000002772 monosaccharides Chemical class 0.000 description 3
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 230000009747 swallowing Effects 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- 240000004160 Capsicum annuum Species 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- 235000003255 Carthamus tinctorius Nutrition 0.000 description 2
- 244000020518 Carthamus tinctorius Species 0.000 description 2
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- 239000004386 Erythritol Substances 0.000 description 2
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 2
- 239000001116 FEMA 4028 Substances 0.000 description 2
- 240000004670 Glycyrrhiza echinata Species 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 239000004378 Glycyrrhizin Substances 0.000 description 2
- 229920000084 Gum arabic Polymers 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- 240000001794 Manilkara zapota Species 0.000 description 2
- 235000011339 Manilkara zapota Nutrition 0.000 description 2
- 229920000057 Mannan Polymers 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 244000062780 Petroselinum sativum Species 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- 239000000205 acacia gum Substances 0.000 description 2
- 235000010489 acacia gum Nutrition 0.000 description 2
- 235000010358 acesulfame potassium Nutrition 0.000 description 2
- 229960004998 acesulfame potassium Drugs 0.000 description 2
- 239000000619 acesulfame-K Substances 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000000605 aspartame Substances 0.000 description 2
- 235000010357 aspartame Nutrition 0.000 description 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
- 229960003438 aspartame Drugs 0.000 description 2
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 229960004853 betadex Drugs 0.000 description 2
- 239000001511 capsicum annuum Substances 0.000 description 2
- 150000001746 carotenes Chemical class 0.000 description 2
- 235000005473 carotenes Nutrition 0.000 description 2
- 229930002875 chlorophyll Natural products 0.000 description 2
- 235000019804 chlorophyll Nutrition 0.000 description 2
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 235000019414 erythritol Nutrition 0.000 description 2
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 2
- 229940009714 erythritol Drugs 0.000 description 2
- 235000012732 erythrosine Nutrition 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 239000001530 fumaric acid Substances 0.000 description 2
- 235000011087 fumaric acid Nutrition 0.000 description 2
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 2
- 229960004949 glycyrrhizic acid Drugs 0.000 description 2
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 2
- 235000019410 glycyrrhizin Nutrition 0.000 description 2
- 238000004128 high performance liquid chromatography Methods 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 229940069445 licorice extract Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- -1 palatinose oligosaccharide Chemical class 0.000 description 2
- 235000011197 perejil Nutrition 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 230000033764 rhythmic process Effects 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 150000005846 sugar alcohols Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000000892 thaumatin Substances 0.000 description 2
- 235000010436 thaumatin Nutrition 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 2
- PHXATPHONSXBIL-UHFFFAOYSA-N xi-gamma-Undecalactone Chemical compound CCCCCCCC1CCC(=O)O1 PHXATPHONSXBIL-UHFFFAOYSA-N 0.000 description 2
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- QNTKVQQLMHZOKP-NEJDVEAASA-N (2r,3r,4s,5s,6r)-2-[(2s,3s,4s,5r)-2-[[(2r,3s,4s,5r)-2-[[(2r,3s,4s,5r)-2-[[(2r,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxymethyl]- Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(O[C@@H]4[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QNTKVQQLMHZOKP-NEJDVEAASA-N 0.000 description 1
- LGQKSQQRKHFMLI-SJYYZXOBSA-N (2s,3r,4s,5r)-2-[(3r,4r,5r,6r)-4,5,6-trihydroxyoxan-3-yl]oxyoxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)OC1 LGQKSQQRKHFMLI-SJYYZXOBSA-N 0.000 description 1
- FVVCFHXLWDDRHG-UPLOTWCNSA-N (2s,3r,4s,5r,6r)-2-[(2r,3s,4r,5r,6r)-6-[(2s,3s,4s,5r)-3,4-dihydroxy-2,5-bis(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)[C@@H](CO)O1 FVVCFHXLWDDRHG-UPLOTWCNSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- ATYSZLKTHMZHJA-UXLSSDPBSA-N (3R,4R,5S,6R)-6-(hydroxymethyl)-2-[(3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2,3,4-triol Chemical compound C1([C@H](O)[C@@H](O)[C@@H](O)[C@H](O1)CO)C1(O)[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO ATYSZLKTHMZHJA-UXLSSDPBSA-N 0.000 description 1
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 description 1
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 1
- RUMOYJJNUMEFDD-SNVBAGLBSA-N (R)-(+)-Perillaldehyde Natural products CC(=C)[C@H]1CCC(C=O)=CC1 RUMOYJJNUMEFDD-SNVBAGLBSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- SVBWNHOBPFJIRU-UHFFFAOYSA-N 1-O-alpha-D-Glucopyranosyl-D-fructose Natural products OC1C(O)C(O)C(CO)OC1OCC1(O)C(O)C(O)C(O)CO1 SVBWNHOBPFJIRU-UHFFFAOYSA-N 0.000 description 1
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 1
- RCSBILYQLVXLJG-UHFFFAOYSA-N 2-Propenyl hexanoate Chemical compound CCCCCC(=O)OCC=C RCSBILYQLVXLJG-UHFFFAOYSA-N 0.000 description 1
- UBVSIAHUTXHQTD-UHFFFAOYSA-N 2-n-(4-bromophenyl)-1,3,5-triazine-2,4-diamine Chemical compound NC1=NC=NC(NC=2C=CC(Br)=CC=2)=N1 UBVSIAHUTXHQTD-UHFFFAOYSA-N 0.000 description 1
- JCSJTDYCNQHPRJ-UHFFFAOYSA-N 20-hydroxyecdysone 2,3-acetonide Natural products OC1C(O)C(O)COC1OC1C(O)C(O)C(OC2C(C(O)C(O)OC2)O)OC1 JCSJTDYCNQHPRJ-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- QIGJYVCQYDKYDW-UHFFFAOYSA-N 3-O-alpha-D-mannopyranosyl-D-mannopyranose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(CO)OC(O)C1O QIGJYVCQYDKYDW-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- LGQKSQQRKHFMLI-UHFFFAOYSA-N 4-O-beta-D-xylopyranosyl-beta-D-xylopyranose Natural products OC1C(O)C(O)COC1OC1C(O)C(O)C(O)OC1 LGQKSQQRKHFMLI-UHFFFAOYSA-N 0.000 description 1
- ODEHMIGXGLNAKK-OESPXIITSA-N 6-kestotriose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1 ODEHMIGXGLNAKK-OESPXIITSA-N 0.000 description 1
- 235000006491 Acacia senegal Nutrition 0.000 description 1
- 239000004377 Alitame Substances 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- CEZCCHQBSQPRMU-LLIZZRELSA-L Allura red AC Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1\N=N\C1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-LLIZZRELSA-L 0.000 description 1
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 description 1
- 240000000662 Anethum graveolens Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000972773 Aulopiformes Species 0.000 description 1
- 244000056139 Brassica cretica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- ZCLAHGAZPPEVDX-UHFFFAOYSA-N D-panose Natural products OC1C(O)C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC1COC1C(O)C(O)C(O)C(CO)O1 ZCLAHGAZPPEVDX-UHFFFAOYSA-N 0.000 description 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 description 1
- SQNRKWHRVIAKLP-UHFFFAOYSA-N D-xylobiose Natural products O=CC(O)C(O)C(CO)OC1OCC(O)C(O)C1O SQNRKWHRVIAKLP-UHFFFAOYSA-N 0.000 description 1
- GGLIEWRLXDLBBF-UHFFFAOYSA-N Dulcin Chemical compound CCOC1=CC=C(NC(N)=O)C=C1 GGLIEWRLXDLBBF-UHFFFAOYSA-N 0.000 description 1
- 240000002943 Elettaria cardamomum Species 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- 239000001329 FEMA 3811 Substances 0.000 description 1
- 239000004214 Fast Green FCF Substances 0.000 description 1
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 235000021559 Fruit Juice Concentrate Nutrition 0.000 description 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 description 1
- 240000001972 Gardenia jasminoides Species 0.000 description 1
- 239000005792 Geraniol Substances 0.000 description 1
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 108010042889 Inulosucrase Proteins 0.000 description 1
- AYRXSINWFIIFAE-SCLMCMATSA-N Isomaltose Natural products OC[C@H]1O[C@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@@H](O)[C@@H](O)[C@@H]1O AYRXSINWFIIFAE-SCLMCMATSA-N 0.000 description 1
- LKDRXBCSQODPBY-AMVSKUEXSA-N L-(-)-Sorbose Chemical compound OCC1(O)OC[C@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-AMVSKUEXSA-N 0.000 description 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 description 1
- SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 235000017858 Laurus nobilis Nutrition 0.000 description 1
- 235000019501 Lemon oil Nutrition 0.000 description 1
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 1
- XJCCHWKNFMUJFE-CGQAXDJHSA-N Maltotriitol Chemical compound O[C@@H]1[C@@H](O)[C@@H](O[C@@H]([C@H](O)[C@@H](O)CO)[C@H](O)CO)O[C@H](CO)[C@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 XJCCHWKNFMUJFE-CGQAXDJHSA-N 0.000 description 1
- 208000001145 Metabolic Syndrome Diseases 0.000 description 1
- 235000009421 Myristica fragrans Nutrition 0.000 description 1
- 240000009023 Myrrhis odorata Species 0.000 description 1
- 235000007265 Myrrhis odorata Nutrition 0.000 description 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 1
- 239000004384 Neotame Substances 0.000 description 1
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 1
- FLDFNEBHEXLZRX-DLQNOBSRSA-N Nystose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(O[C@@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 FLDFNEBHEXLZRX-DLQNOBSRSA-N 0.000 description 1
- AYRXSINWFIIFAE-UHFFFAOYSA-N O6-alpha-D-Galactopyranosyl-D-galactose Natural products OCC1OC(OCC(O)C(O)C(O)C(O)C=O)C(O)C(O)C1O AYRXSINWFIIFAE-UHFFFAOYSA-N 0.000 description 1
- FSJSODMMIYGSTK-AGJIYOFVSA-N OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC[C@H]3O[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O Chemical compound OC[C@H]1O[C@@H](OC[C@H]2O[C@@H](OC[C@H]3O[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@@H](O)[C@@H]2O)[C@H](O)[C@@H](O)[C@@H]1O FSJSODMMIYGSTK-AGJIYOFVSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 235000019502 Orange oil Nutrition 0.000 description 1
- 206010068319 Oropharyngeal pain Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 201000007100 Pharyngitis Diseases 0.000 description 1
- 235000006990 Pimenta dioica Nutrition 0.000 description 1
- 240000008474 Pimenta dioica Species 0.000 description 1
- 235000012550 Pimpinella anisum Nutrition 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 240000003889 Piper guineense Species 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 description 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 235000011341 Sideroxylon dulcificum Nutrition 0.000 description 1
- UQZIYBXSHAGNOE-USOSMYMVSA-N Stachyose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](CO[C@@H]2[C@@H](O)[C@@H](O)[C@@H](O)[C@H](CO)O2)O1 UQZIYBXSHAGNOE-USOSMYMVSA-N 0.000 description 1
- 238000000692 Student's t-test Methods 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- OIQPTROHQCGFEF-QIKYXUGXSA-L Sunset Yellow FCF Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-QIKYXUGXSA-L 0.000 description 1
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 1
- 244000223014 Syzygium aromaticum Species 0.000 description 1
- 235000005212 Terminalia tomentosa Nutrition 0.000 description 1
- 244000125380 Terminalia tomentosa Species 0.000 description 1
- 240000007326 Thaumatococcus daniellii Species 0.000 description 1
- 235000005266 Thaumatococcus daniellii Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 description 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- KPQJOKRSYYJJEL-VLQRKCJKSA-K [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O Chemical compound [Na+].[Na+].CC1(C)[C@H](CC[C@@]2(C)[C@H]1CC[C@]1(C)[C@@H]2C(=O)C=C2[C@@H]3C[C@](C)(CC[C@]3(C)CC[C@@]12C)C([O-])=O)O[C@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O[C@@H]1O[C@@H]([C@@H](O)[C@H](O)[C@H]1O)C([O-])=O)C([O-])=O KPQJOKRSYYJJEL-VLQRKCJKSA-K 0.000 description 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000019409 alitame Nutrition 0.000 description 1
- 108010009985 alitame Proteins 0.000 description 1
- 235000012741 allura red AC Nutrition 0.000 description 1
- 239000004191 allura red AC Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- HDTRYLNUVZCQOY-BTLHAWITSA-N alpha,beta-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-BTLHAWITSA-N 0.000 description 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
- 229940043377 alpha-cyclodextrin Drugs 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000004410 anthocyanin Substances 0.000 description 1
- 235000010208 anthocyanin Nutrition 0.000 description 1
- 229930002877 anthocyanin Natural products 0.000 description 1
- 150000004636 anthocyanins Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- PYMYPHUHKUWMLA-WDCZJNDASA-N arabinose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)C=O PYMYPHUHKUWMLA-WDCZJNDASA-N 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000021028 berry Nutrition 0.000 description 1
- FBJQEBRMDXPWNX-CFCQXFMMSA-N beta-D-Glcp-(1->6)-beta-D-Glcp-(1->6)-beta-D-Glcp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)[C@H](O)O2)O)O1 FBJQEBRMDXPWNX-CFCQXFMMSA-N 0.000 description 1
- JCSJTDYCNQHPRJ-FDVJSPBESA-N beta-D-Xylp-(1->4)-beta-D-Xylp-(1->4)-D-Xylp Chemical compound O[C@@H]1[C@@H](O)[C@H](O)CO[C@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O)C(O)OC2)O)OC1 JCSJTDYCNQHPRJ-FDVJSPBESA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- DLRVVLDZNNYCBX-ZZFZYMBESA-N beta-melibiose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](O)O1 DLRVVLDZNNYCBX-ZZFZYMBESA-N 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000012745 brilliant blue FCF Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 235000005300 cardamomo Nutrition 0.000 description 1
- 235000012730 carminic acid Nutrition 0.000 description 1
- 239000004106 carminic acid Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 1
- 229940117916 cinnamic aldehyde Drugs 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 229940043350 citral Drugs 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000001279 citrus aurantifolia swingle expressed oil Substances 0.000 description 1
- 239000001071 citrus reticulata blanco var. mandarin Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 229940080423 cochineal Drugs 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 108010010165 curculin Proteins 0.000 description 1
- 229940109275 cyclamate Drugs 0.000 description 1
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- SPPIIOPGDLITJE-VLQRKCJKSA-N diazanium;(2s,3s,4s,5r,6s)-6-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-5-[(2r,3r,4s,5s,6s)-6-carboxy-3,4,5-trihydroxyoxan-2-yl]oxy-3,4-dihy Chemical compound N.N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O SPPIIOPGDLITJE-VLQRKCJKSA-N 0.000 description 1
- JBBPTUVOZCXCSU-UHFFFAOYSA-L dipotassium;2',4',5',7'-tetrabromo-4,7-dichloro-3-oxospiro[2-benzofuran-1,9'-xanthene]-3',6'-diolate Chemical compound [K+].[K+].O1C(=O)C(C(=CC=C2Cl)Cl)=C2C21C1=CC(Br)=C([O-])C(Br)=C1OC1=C(Br)C([O-])=C(Br)C=C21 JBBPTUVOZCXCSU-UHFFFAOYSA-L 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000008126 dulcin Substances 0.000 description 1
- NWNUTSZTAUGIGA-UHFFFAOYSA-N dulcin Natural products C12CC(C)(C)CCC2(C(=O)OC2C(C(O)C(O)C(COC3C(C(O)C(O)CO3)O)O2)O)C(O)CC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1OC1OC(CO)C(O)C(O)C1O NWNUTSZTAUGIGA-UHFFFAOYSA-N 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
- 239000004174 erythrosine Substances 0.000 description 1
- 229940011411 erythrosine Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 235000019240 fast green FCF Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- QNTKVQQLMHZOKP-UHFFFAOYSA-N fructofuranosylnystose Natural products OC1C(O)C(CO)OC1(CO)OCC1(OCC2(OCC3(OC4C(C(O)C(O)C(CO)O4)O)C(C(O)C(CO)O3)O)C(C(O)C(CO)O2)O)C(O)C(O)C(CO)O1 QNTKVQQLMHZOKP-UHFFFAOYSA-N 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- DBTMGCOVALSLOR-AXAHEAMVSA-N galactotriose Natural products OC[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](CO)O[C@@H](O[C@H]3[C@@H](O)[C@H](O)O[C@@H](CO)[C@@H]3O)[C@@H]2O)[C@H](O)[C@H](O)[C@H]1O DBTMGCOVALSLOR-AXAHEAMVSA-N 0.000 description 1
- PHXATPHONSXBIL-JTQLQIEISA-N gamma-Undecalactone Natural products CCCCCCC[C@H]1CCC(=O)O1 PHXATPHONSXBIL-JTQLQIEISA-N 0.000 description 1
- 229940020436 gamma-undecalactone Drugs 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- DLRVVLDZNNYCBX-CQUJWQHSSA-N gentiobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-CQUJWQHSSA-N 0.000 description 1
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 1
- 229940113087 geraniol Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 229960005150 glycerol Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- 239000010651 grapefruit oil Substances 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- KHLVKKOJDHCJMG-QDBORUFSSA-L indigo carmine Chemical compound [Na+].[Na+].N/1C2=CC=C(S([O-])(=O)=O)C=C2C(=O)C\1=C1/NC2=CC=C(S(=O)(=O)[O-])C=C2C1=O KHLVKKOJDHCJMG-QDBORUFSSA-L 0.000 description 1
- 229960003988 indigo carmine Drugs 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- FBJQEBRMDXPWNX-FYHZSNTMSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H]2[C@H]([C@H](O)[C@@H](O)C(O)O2)O)O1 FBJQEBRMDXPWNX-FYHZSNTMSA-N 0.000 description 1
- 239000000832 lactitol Substances 0.000 description 1
- 235000010448 lactitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 1
- 229960003451 lactitol Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- JCQLYHFGKNRPGE-FCVZTGTOSA-N lactulose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 JCQLYHFGKNRPGE-FCVZTGTOSA-N 0.000 description 1
- 229960000511 lactulose Drugs 0.000 description 1
- PFCRQPBOOFTZGQ-UHFFFAOYSA-N lactulose keto form Natural products OCC(=O)C(O)C(C(O)CO)OC1OC(CO)C(O)C(O)C1O PFCRQPBOOFTZGQ-UHFFFAOYSA-N 0.000 description 1
- 239000010501 lemon oil Substances 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- SXQCTESRRZBPHJ-UHFFFAOYSA-M lissamine rhodamine Chemical compound [Na+].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S([O-])(=O)=O)C=C1S([O-])(=O)=O SXQCTESRRZBPHJ-UHFFFAOYSA-M 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 229940043353 maltol Drugs 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 230000018984 mastication Effects 0.000 description 1
- 238000010077 mastication Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 1
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 1
- 235000010434 neohesperidine DC Nutrition 0.000 description 1
- 235000019412 neotame Nutrition 0.000 description 1
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 1
- 108010070257 neotame Proteins 0.000 description 1
- QIGJYVCQYDKYDW-NSYYTRPSSA-N nigerose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](CO)OC(O)[C@@H]1O QIGJYVCQYDKYDW-NSYYTRPSSA-N 0.000 description 1
- FLDFNEBHEXLZRX-UHFFFAOYSA-N nystose Natural products OC1C(O)C(CO)OC1(CO)OCC1(OCC2(OC3C(C(O)C(O)C(CO)O3)O)C(C(O)C(CO)O2)O)C(O)C(O)C(CO)O1 FLDFNEBHEXLZRX-UHFFFAOYSA-N 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 239000008601 oleoresin Substances 0.000 description 1
- 239000010502 orange oil Substances 0.000 description 1
- ZCLAHGAZPPEVDX-MQHGYYCBSA-N panose Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@@H](O[C@H]([C@H](O)CO)[C@H](O)[C@@H](O)C=O)O[C@@H]1CO[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ZCLAHGAZPPEVDX-MQHGYYCBSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 235000019477 peppermint oil Nutrition 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- RUMOYJJNUMEFDD-UHFFFAOYSA-N perillyl aldehyde Chemical compound CC(=C)C1CCC(C=O)=CC1 RUMOYJJNUMEFDD-UHFFFAOYSA-N 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- AZJPTIGZZTZIDR-UHFFFAOYSA-L rose bengal Chemical compound [K+].[K+].[O-]C(=O)C1=C(Cl)C(Cl)=C(Cl)C(Cl)=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 AZJPTIGZZTZIDR-UHFFFAOYSA-L 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 229960002920 sorbitol Drugs 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000009495 sugar coating Methods 0.000 description 1
- 235000012751 sunset yellow FCF Nutrition 0.000 description 1
- 239000004173 sunset yellow FCF Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 235000012756 tartrazine Nutrition 0.000 description 1
- 239000004149 tartrazine Substances 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- NMXLJRHBJVMYPD-IPFGBZKGSA-N trehalulose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@]1(O)CO[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 NMXLJRHBJVMYPD-IPFGBZKGSA-N 0.000 description 1
- 229940074777 tripotassium glycyrrhizinate Drugs 0.000 description 1
- ZXHXYXSTAYNRLQ-DWJAGBRCSA-K tripotassium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4, Chemical compound [K+].[K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O ZXHXYXSTAYNRLQ-DWJAGBRCSA-K 0.000 description 1
- CCXAYLQLOLXXKE-DWJAGBRCSA-K trisodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-t Chemical compound [Na+].[Na+].[Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C([O-])=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O CCXAYLQLOLXXKE-DWJAGBRCSA-K 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- ABKNGTPZXRUSOI-UHFFFAOYSA-N xylotriose Natural products OCC(OC1OCC(OC2OCC(O)C(O)C2O)C(O)C1O)C(O)C(O)C=O ABKNGTPZXRUSOI-UHFFFAOYSA-N 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/20—Reducing nutritive value; Dietetic products with reduced nutritive value
- A23L33/21—Addition of substantially indigestible substances, e.g. dietary fibres
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- Dietary restrictions may be required to prevent or treat metabolic syndrome, diabetes, obesity, arteriosclerosis, and the like. However, in the case of dietary restrictions, dietary restrictions may not be achieved by ingesting heat (calories) other than the prescribed amount without being able to withstand a feeling of hunger. There has been a demand for providing a composition that relieves hunger without ingesting heat or with low heat intake. In the present specification, alleviating feeling of hunger includes perception of feeling in the stomach or feeling in the stomach.
- composition that relieves hunger without ingesting heat or with low heat intake.
- composition comprising glucomannan and a gum base, which, when chewed, perceives a feeling of entering the stomach or a feeling of being present in the stomach and relieves hunger.
- Example 2 The time schedule in Example 2 is shown. It is a figure explaining the subjective evaluation of Example 6.
- the present invention includes glucomannan and a gum base, and when chewed, glucomannan is swallowed together with saliva, and as a result, it feels a feeling of entering the stomach and a feeling existing in the stomach, thereby reducing the feeling of hunger.
- a composition is provided.
- the present invention also provides the above composition, wherein glucomannan is contained in a proportion of 1 to 10% by weight.
- the present invention also provides the above composition, wherein the composition is shaped so as to be 1 to 10 g per piece.
- the present invention provides the above composition characterized in that it is molded so that the amount of glucomannan per unit is 0.01 to 1 g.
- Glucomannan is a water-soluble polysaccharide in which glucose and mannose are ⁇ -1,4-linked. Glucomannan is abundant in the cell walls of plant cells, and is particularly known to be abundant in salmon. In the composition of the present invention, glucomannan is preferably contained in the composition in a proportion of 1 to 10% by weight, more preferably in a proportion of 2 to 3% by weight. The intake is preferably about 0.01 to 1 g, more preferably about 0.01 to 0.05 g.
- the gum base is a base for the chewing gum and is not particularly limited as long as it has an appropriate elasticity for chewing and is harmless to the human body.
- gum base leguminous tree arabic rubber tree (Acacia senegal), gum arabic, which is a secreted product of related plants of the same genus, sapodilla (Achras sapota), a sap of pine, a sap of pine ( Examples include ester gum produced by processing pine resin, vinyl acetate resin (polyvinyl acetate), which is a synthetic resin, and polyisobutylene.
- an additive such as calcium carbonate may be added to the gum base, and sweeteners, flavors and the like may be added for flavoring.
- the composition of the present invention can contain a sweetener.
- sweeteners include monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and high intensity sweeteners.
- monosaccharides such as arabinose, galactose, xylose, glucose, fucose, sorbose, fructose, rhamnose, ribose, isomerized liquid sugar, N-acetylglucosamine; isotrehalose, sucrose, trehalulose, trehalose, neotrehalose, palatinose , Maltose, melibiose, lactulose, lactose and other disaccharides; ⁇ -cyclodextrin, ⁇ -cyclodextrin, isomaltoligosaccharides (isomaltose, isomaltotriose, panose, etc.), oligo-N-acetylglucosamine, galactosy
- sweeteners can be used alone or in any combination of two or more.
- monosaccharides, disaccharides, oligosaccharides, and sugar alcohols are added to the composition of the present invention, it is preferable to add 50 to 70% by weight.
- high-intensity sweetener it is preferable to add 0 to 2% by weight in the composition of the present invention.
- composition of the present invention can contain a fragrance.
- flavors used include citrus essential oils such as orange oil, lemon oil, grapefruit oil, lime oil, tangerine oil, mandarin oil, mint essential oils such as peppermint oil, spearmint oil, allspice, anise seed
- Known spice essential oils such as basil, laurel, cardamom, celery, clove, cinnamon, cumin, dill, garlic, parsley, mace, mustard, onion, paprika, parsley, rosemary, pepper, or oleoresin, limonene, Linalool, nerol, citronellol, geraniol, citral, L-menthol, eugenol, cinnamic aldehyde, anethole, perilla aldehyde, vanillin, ⁇ -undecalactone, allyl caproate, L-carvone, maltol.
- known isolated or synthetic fragrances such as citrus essential oils, mint essential oils, spice essential oils or isolated / synthetic fragrances according to the purpose
- the present invention is not limited to these exemplified substances.
- the fragrance it is preferable to add 0 to 3% by weight when it is added to the chewing gum composition.
- composition of the present invention is a sour agent such as citric acid, malic acid, fumaric acid, ascorbic acid, caramel dye, gardenia dye, anthocyanin dye, anato dye, paprika dye, safflower dye, safflower dye, flavonoid dye, cochineal Dye, Amaranth (Red No. 2), Erythrosine (Red No. 3), Allura Red AC (Red No. 40), New Coxin (Red No. 102), Phloxin (Red No. 104), Rose Bengal (Red No.
- a sour agent such as citric acid, malic acid, fumaric acid, ascorbic acid, caramel dye, gardenia dye, anthocyanin dye, anato dye, paprika dye, safflower dye, safflower dye, flavonoid dye, cochineal Dye, Amaranth (Red No. 2), Erythrosine (Red No. 3),
- Acid Red (Red 106), Tartrazine (Yellow 4), Sunset Yellow FCF (Yellow 5), Fast Green FCF (Green 3), Brilliant Blue FCF (Blue 1), Indigo Carmine (Blue 2), etc.
- oil-soluble bases such as carotene, chlorophyll, and tocopher
- Such Lumpur may contain harmless other additives to further human body.
- the composition of the present invention is preferably formed in a single dose so that the intake amount per time is preferably 1 to 10 grams, more preferably 1.5 to 5 g, and most preferably 2 to 3 g. preferable.
- the shape is not limited, and plate shape, granular shape, cube shape, rectangular parallelepiped shape, ball shape, and other shapes can be raised, and after forming, coating may be made with sugar coating or the like.
- another composition such as a liquid or a solid may be contained in the inside or the like.
- a liquid part can be included, or a candy or gummy can be included for the purpose of imparting an interesting texture or improving the flavor.
- the weight of these other compositions is not included in the composition of the present invention.
- the composition of the present invention is intended to assist dietary restriction, it is desirable that the calories be low, and preferably the caloric intake of the composition of the present invention is from 0 to 12 kilocalories, more Preferably it is from 0 to 3 kilocalories.
- the amount of carbohydrate contained in one intake of the composition of the present invention is preferably 0 to 3 grams, more preferably 0 to 1 grams.
- Example 1 Subjective evaluation of glucomannan solution (first time) A subjective evaluation of the glucomannan solution was performed on 10 panelists (all women). 10 ml of the control solution was weighed with a syringe and injected into the mouth of the panel as it was. Ten minutes later, a 0.2% or 0.4% glucomannan solution, like the control solution, was weighed in the same amount of 10 ml with a syringe and injected into the mouth of the panel to be ingested. Immediately after ingestion, the panel subjectively evaluated the items in Table 1 compared to the control solution. The results are summarized in Tables 2 and 3.
- control solution 2.0% by weight maltitol Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt% Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
- Example 2 Subjective evaluation of glucomannan solution (second time) A subjective evaluation of the glucomannan solution was performed on 12 panelists (all women). The panel was fasted for 4 hours before evaluation and the evaluation was performed on an empty stomach. In addition, there was no particular restriction on the intake of liquids even during fasting.
- Evaluation was performed as follows. That is, 10 ml of the control solution was weighed with a syringe and injected into the mouth of the panel to ingest it. Ten minutes after that, similarly to the control solution, 10 ml of the same concentration of glucomannan solution was weighed with a syringe and injected into the mouth of the panel for ingestion. Immediately after ingestion, the panel performed a subjective evaluation on the same items as in Example 1 in comparison with the control solution. Further, the evaluation was performed by reversing the order of intake. The time schedule in the present embodiment is shown in FIG. The results are summarized in Tables 4-12.
- control solution 2.0% by weight maltitol Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt% Glucomannan solution (0.3%): maltitol 2.0 wt%, glucomannan 0.3 wt% Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
- Glucomannan Blending Gum The following glucomannan blending gum was produced as an example of the composition of the present invention. The production method was based on a normal gum production method, and a gum base, a powder raw material, and a liquid raw material were mixed at around 50 to 60 ° C. Glucomannan can be purchased as, for example, ROLEX (trademark) One (Shimizu Chemical Co., Ltd.).
- Example 4 Measurement of the amount of saliva when chewing gum containing glucomannan The weight of saliva secreted by chewing about 2.1 g of glucomannan-containing gum produced by Example 3 by three female panels (panels A, B, C) was measured. At the timing of swallowing saliva, it was discharged into a test tube and its weight was measured. The test tube was changed every 1 minute and measured up to 8 minutes. According to the rhythm of the metronome, it was chewed at a pace of 80 times per minute. The results are shown in Table 13.
- Example 5 Measurement of the amount of glucomannan eluted from the glucomannan-containing gum 2.1 grams of the glucomannan-containing gum produced in Example 3 is 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, or 8 minutes Mastication was performed at a pace of 80 times per minute according to the rhythm of the metronome, the amount of glucomannan remaining in the glucomannan-containing gum after chewing was measured, and the amount and dissolution rate were calculated. As a control, measurements were also made on a glucomannan-containing gum that was not chewed. The measurement method is as follows.
- Example 6 Subjective evaluation when chewing glucomannan-containing gum About 2.1 g of glucomannan-containing gum produced in Example 3 for 6 male panels (panels 1-6) and 6 female panels (panels 7-12), Alternatively, about 2.1 g of control gum was chewed for 7 minutes. The chewing method was not specified. In addition, the control gum used here is obtained by substituting 2.4% of glucomannan in the blended glucomannan of Example 3 with 2.4% of maltitol. The chewing hours were 11:00 am to 12:00 am and 4 pm to 5:00 pm, which are thought to make it easy to feel hungry.
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Confectionery (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
A composition for alleviating hunger sensation without caloric intake or by low caloric intake is provided. Provided is a composition characterized in comprising glucomannan and a gum base, and in that saliva containing glucomannan is swallowed by chewing, whereby the sensation of entering the stomach and the sensation of being present in the stomach is strongly perceived, and hunger sensation is alleviated.
Description
メタボリックシンドローム、糖尿病、肥満、動脈硬化などの予防、治療のため、食事制限が必要な場合がある。しかしながら、食事制限の際は、空腹感に耐えられずに、規定以外の熱量(カロリー)を摂取してしまうことで、食事制限を達成できないことがある。
熱量を摂取することなく、あるいは低い熱量の摂取で、空腹感を緩和する組成物の提供が求められてきた。なお、本明細書中、空腹感を緩和するとは、胃に入った感じ、あるいは、胃に存在する感じを知覚させることを含む。 Dietary restrictions may be required to prevent or treat metabolic syndrome, diabetes, obesity, arteriosclerosis, and the like. However, in the case of dietary restrictions, dietary restrictions may not be achieved by ingesting heat (calories) other than the prescribed amount without being able to withstand a feeling of hunger.
There has been a demand for providing a composition that relieves hunger without ingesting heat or with low heat intake. In the present specification, alleviating feeling of hunger includes perception of feeling in the stomach or feeling in the stomach.
熱量を摂取することなく、あるいは低い熱量の摂取で、空腹感を緩和する組成物の提供が求められてきた。なお、本明細書中、空腹感を緩和するとは、胃に入った感じ、あるいは、胃に存在する感じを知覚させることを含む。 Dietary restrictions may be required to prevent or treat metabolic syndrome, diabetes, obesity, arteriosclerosis, and the like. However, in the case of dietary restrictions, dietary restrictions may not be achieved by ingesting heat (calories) other than the prescribed amount without being able to withstand a feeling of hunger.
There has been a demand for providing a composition that relieves hunger without ingesting heat or with low heat intake. In the present specification, alleviating feeling of hunger includes perception of feeling in the stomach or feeling in the stomach.
熱量を摂取することなく、あるいは低い熱量の摂取で、空腹感を緩和する組成物の提供。
Provide a composition that relieves hunger without ingesting heat or with low heat intake.
グルコマンナンとガムベースを含み、咀嚼されることで、胃に入った感じや、胃に存在する感じを知覚させ、空腹感を緩和することを特徴とする組成物を提供する。
Provided is a composition comprising glucomannan and a gum base, which, when chewed, perceives a feeling of entering the stomach or a feeling of being present in the stomach and relieves hunger.
胃に入った感じや、胃に存在する感じを知覚させ、空腹感が緩和されるため、食事制限の達成を容易にする。
Sense the feeling of entering the stomach and the feeling of being in the stomach, and the feeling of hunger is alleviated, making it easier to achieve dietary restrictions.
本発明はグルコマンナンとガムベースを含み、咀嚼されることでグルコマンナンが唾液と共に飲み込まれ、その結果、胃に入った感じや、胃に存在する感じを知覚させ、空腹感を緩和することを特徴とする組成物を提供する。また、本発明はグルコマンナンが1~10重量%の割合で含有されることを特徴とする上記組成物を提供する。また、本発明は1個あたり1~10gとなるように成形されていることを特徴とする上記組成物を提供する。さらに、本発明は、1個あたりグルコマンナンの量が0.01~1gとなるように成形されたことを特徴とする上記組成物を提供する。
The present invention includes glucomannan and a gum base, and when chewed, glucomannan is swallowed together with saliva, and as a result, it feels a feeling of entering the stomach and a feeling existing in the stomach, thereby reducing the feeling of hunger. A composition is provided. The present invention also provides the above composition, wherein glucomannan is contained in a proportion of 1 to 10% by weight. The present invention also provides the above composition, wherein the composition is shaped so as to be 1 to 10 g per piece. Furthermore, the present invention provides the above composition characterized in that it is molded so that the amount of glucomannan per unit is 0.01 to 1 g.
グルコマンナン(glucomannan)は、グルコースとマンノースがβ-1,4-結合した水溶性多糖である。グルコマンナンは植物細胞の細胞壁に多く含まれ、特に、蒟蒻芋に多く含まれることで知られる。本発明の組成物に、グルコマンナンは好ましくは1~10重量%の割合で、より好ましくは2~3重量%の割合で、本組成物中に含まれ、重量としては、一度のグルコマンナンの摂取量が0.01~1g、より好ましくは約0.01g~0.05g程度となることが好ましい。
Glucomannan is a water-soluble polysaccharide in which glucose and mannose are β-1,4-linked. Glucomannan is abundant in the cell walls of plant cells, and is particularly known to be abundant in salmon. In the composition of the present invention, glucomannan is preferably contained in the composition in a proportion of 1 to 10% by weight, more preferably in a proportion of 2 to 3% by weight. The intake is preferably about 0.01 to 1 g, more preferably about 0.01 to 0.05 g.
ガムベースとは、チューインガムのベースとなるもので、咀嚼にするのに適度な弾力があり、人体に無害なものであれば、特に限定されない。ガムベースの例として、マメ科の樹木アラビアゴムノキ (Acacia senegal)、またはその同属近縁植物の分泌物であるアラビアガム、アカテツ科の樹木であるサポジラ (Achras sapota)から得られるチクル、マツの樹液(松脂)を加工して作るエステルガム、合成樹脂である酢酸ビニル樹脂(ポリ酢酸ビニル)、ポリイソブチレンなどをあげることができる。ガムベースには、硬さを保持するために、炭酸カルシウムなどの添加物を加えてもよく、また、風味付けのために、甘味料、香料などを加えてもよい。
The gum base is a base for the chewing gum and is not particularly limited as long as it has an appropriate elasticity for chewing and is harmless to the human body. As an example of gum base, leguminous tree arabic rubber tree (Acacia senegal), gum arabic, which is a secreted product of related plants of the same genus, sapodilla (Achras sapota), a sap of pine, a sap of pine ( Examples include ester gum produced by processing pine resin, vinyl acetate resin (polyvinyl acetate), which is a synthetic resin, and polyisobutylene. In order to maintain hardness, an additive such as calcium carbonate may be added to the gum base, and sweeteners, flavors and the like may be added for flavoring.
本発明の組成物は甘味料を含むことができる。甘味料の例としては、単糖類、二糖類、オリゴ糖類、糖アルコール類、高甘味度甘味料を挙げることができる。具体的には、アラビノース、ガラクトース、キシロース、グルコース、フコース、ソルボース、フルクトース、ラムノース、リボース、異性化液糖、N-アセチルグルコサミン等の単糖類;イソトレハロース、スクロース、トレハルロース、トレハロース、ネオトレハロース、パラチノース、マルトース、メリビオース、ラクチュロース、ラクトース等の二糖類;α-サイクロデキストリン、β-サイクロデキストリン、イソマルトオリゴ糖(イソマルトース、イソマルトトリオース、パノース等)、オリゴ-N-アセチルグルコサミン、ガラクトシルスクロース、ガラクトシルラクトース、ガラクトピラノシル(β1-3)ガラクトピラノシル(β1-4) グルコピラノース、ガラクトピラノシル(β1-3)グルコピラノース、ガラクトピラノシル(β1-6)ガラクトピラノシル (β1-4) グルコピラノース、ガラクトピラノシル(β1-6)グルコピラノース、キシロオリゴ糖(キシロトリオース、キシロビオース等)、ゲンチオオリゴ糖(ゲンチオビオース、ゲンチオトリオース、ゲンチオテトラオース等)、スタキオース、テアンデオリゴ、ニゲロオリゴ糖(ニゲロース等)、パラチノースオリゴ糖、パラチノースシロップ、フラクトオリゴ糖(ケストース、ニストース等)、フラクトフラノシルニストース、ポリデキストロース、マルトシル-β-サイクロデキストリン、マルトオリゴ糖(マルトトリオース、テトラオース、ペンタオース、ヘキサオース、ヘプタオース等)、ラフィノース、砂糖結合水飴(カップリングシュガー)、大豆オリゴ糖、転化糖、水飴等のオリゴ糖類;イソマルチトール、エリスリトール、キシリトール、グリセロール、ソルビトール、パラチニット、マルチトール、マルトテトライトール、マルトトリイトール、マンニトール、ラクチトール、還元イソマルトオリゴ糖、還元キシロオリゴ糖、還元ゲンチオオリゴ糖、還元麦芽糖水飴、還元水飴等の糖アルコール;α-グルコシルトランスフェラーゼ処理ステビア、アスパルテーム、アセスルファムカリウム、アリテーム、カンゾウ抽出物(グリチルリチン)、グリチルリチン酸三アンモニウム、グリチルリチン酸三カリウム、グリチルリチン酸三ナトリウム、グリチルリチン酸二アンモニウム、グリチルリチン酸二カリウム、グリチルリチン酸二ナトリウム、クルクリン、サッカリン、サッカリンナトリウム、シクラメート、スクラロース、ステビア抽出物、ステビア末、ズルチン、タウマチン(ソーマチン)、テンリョウチャ抽出物、ナイゼリアベリー抽出物、ネオテーム、ネオヘスペリジンジヒドロカルコン、フラクトシルトランスフェラーゼ処理ステビア、ブラジルカンゾウ抽出物、ミラクルフルーツ抽出物、ラカンカ抽出物、酵素処理カンゾウ、酵素分解カンゾウ等の高甘味度甘味料;その他蜂蜜、果汁、果汁濃縮物等を例示することができる。これらの甘味料は1種単独で使用することも2種以上を任意に組み合わせて使用することもできる。単糖類、二糖類、オリゴ糖類及び糖アルコール類については、本発明の組成物に配合させる場合、50~70重量%を配合するのが好適である。また高甘味度甘味料については、本発明の組成物中、0~2重量%を配合するのが好適である。
The composition of the present invention can contain a sweetener. Examples of sweeteners include monosaccharides, disaccharides, oligosaccharides, sugar alcohols, and high intensity sweeteners. Specifically, monosaccharides such as arabinose, galactose, xylose, glucose, fucose, sorbose, fructose, rhamnose, ribose, isomerized liquid sugar, N-acetylglucosamine; isotrehalose, sucrose, trehalulose, trehalose, neotrehalose, palatinose , Maltose, melibiose, lactulose, lactose and other disaccharides; α-cyclodextrin, β-cyclodextrin, isomaltoligosaccharides (isomaltose, isomaltotriose, panose, etc.), oligo-N-acetylglucosamine, galactosylsucrose, galactosyl Lactose, galactopyranosyl (β1-3) galactopyranosyl (β1-4) glucopyranose, galactopyranosyl (β1-3) glucopyranose, galactopi Lanosyl (β1-6) galactopyranosyl (β1-4) glucopyranose, galactopyranosyl (β1-6) glucopyranose, xylo-oligosaccharide (xylotriose, xylobiose, etc.), gentio-oligosaccharide (gentiobiose, gentiotriose, Gentiotetraose, etc.), stachyose, theande oligo, nigerooligosaccharide (eg, nigerose), palatinose oligosaccharide, palatinose syrup, fructooligosaccharide (kestose, nystose, etc.), fructofuranosyl nystose, polydextrose, maltosyl-β-cyclodextrin, Malto-oligosaccharides (maltotriose, tetraose, pentaose, hexaose, heptaose, etc.), raffinose, sugar-bound starch syrup (coupling sugar), soybean oligosaccharide, invert sugar, syrup Oligosaccharides: isomalitol, erythritol, xylitol, glycerol, sorbitol, palatinit, maltitol, maltoteitol, maltotriitol, mannitol, lactitol, reduced isomaltoligosaccharide, reduced xylooligosaccharide, reduced gentiooligosaccharide, reduced maltose starch syrup Α-glucosyltransferase-treated stevia, aspartame, acesulfame potassium, alitame, licorice extract (glycyrrhizin), triammonium glycyrrhizinate, tripotassium glycyrrhizinate, trisodium glycyrrhizinate, diammonium glycyrrhizinate, glycyrrhizin Dipotassium acid, disodium glycyrrhizinate, curculin, saccharin, saccharin sodium, cyclamate Sucralose, stevia extract, stevia powder, dulcin, thaumatin (thaumatin), tenroucha extract, nigerian berry extract, neotame, neohesperidin dihydrochalcone, fructosyltransferase-treated stevia, brazilian licorice extract, miracle fruit extract, lacanka Examples include high-sweetness sweeteners such as extracts, enzyme-treated licorice, and enzyme-decomposed licorice; and other honey, fruit juice, fruit juice concentrate, and the like. These sweeteners can be used alone or in any combination of two or more. When monosaccharides, disaccharides, oligosaccharides, and sugar alcohols are added to the composition of the present invention, it is preferable to add 50 to 70% by weight. As for the high-intensity sweetener, it is preferable to add 0 to 2% by weight in the composition of the present invention.
本発明の組成物は香料を含むことができる。使用される香料の例としては、オレンジ油、レモン油、グレープフルーツ油、ライム油、タンジェリン油、マンダリン油などの柑橘精油類、ペパーミント油、スペアミント油、のようなミント精油類、オールスパイス、アニスシード、バジル、ローレル、カルダモン、セロリー、クローブ、シンナモン、クミン、ディル、ガーリック、パセリ、メース、マスタード、オニオン、パプリカ、パセリ、ローズマリー、ペッパーのような公知のスパイス精油類またはオレオレジン類、リモネン、リナロール、ネロール、シトロネロール、ゲラニオール、シトラール、L-メントール、オイゲノール、シンナミックアルデハイド、アネトール、ペリラアルデハイド、バニリン、γ-ウンデカラクトン、カプロン酸アリル、L-カルボン、マルトールなどのような公知の単離、または合成香料、および、これら柑橘精油類、ミント精油類、スパイス精油類または単離・合成香料を目的に沿った割合で混合したシトラスミックス、ミックスミント、各種フルーツなどを表現させた調合香料が挙げられ、その他、ガム用油溶性基剤であるカロチン、クロロフィル、トコフェロールなどを含んでもよいが、本発明では、これらの例示物質に限定されるものではない。香料については、チューインガム組成物に配合させる場合、0~3重量%を配合するのが好適である。
The composition of the present invention can contain a fragrance. Examples of flavors used include citrus essential oils such as orange oil, lemon oil, grapefruit oil, lime oil, tangerine oil, mandarin oil, mint essential oils such as peppermint oil, spearmint oil, allspice, anise seed Known spice essential oils such as basil, laurel, cardamom, celery, clove, cinnamon, cumin, dill, garlic, parsley, mace, mustard, onion, paprika, parsley, rosemary, pepper, or oleoresin, limonene, Linalool, nerol, citronellol, geraniol, citral, L-menthol, eugenol, cinnamic aldehyde, anethole, perilla aldehyde, vanillin, γ-undecalactone, allyl caproate, L-carvone, maltol. Citrus mix, mix mint, various fruits, etc. mixed with known isolated or synthetic fragrances such as citrus essential oils, mint essential oils, spice essential oils or isolated / synthetic fragrances according to the purpose In addition, although it may include carotene, chlorophyll, tocopherol and the like, which are oil-soluble bases for gums, the present invention is not limited to these exemplified substances. As for the fragrance, it is preferable to add 0 to 3% by weight when it is added to the chewing gum composition.
その他、本発明の組成物はクエン酸、リンゴ酸、フマル酸、アスコルビン酸などの酸味料、カラメル色素、クチナシ色素、アントシアニン色素、アナトー色素、パプリカ色素、紅花色素、紅麹色素、フラボノイド色素、コチニール色素、アマランス(赤色2号)、エリスロシン(赤色3号)、アルラレッドAC(赤色40号)、ニューコクシン(赤色102号)、フロキシン(赤色104号)、ローズベンガル(赤色105号)、アシッドレッド(赤色106号)、タートラジン(黄色4号)、サンセットイエローFCF(黄色5号)、ファストグリーンFCF(緑色3号)、ブリリアントブルーFCF(青色1号)、インジゴカルミン(青色2号)等の色素を含むことができ、また、油溶性基剤であるカロチン、クロロフィル、トコフェロールなど、さらに人体に無害の他の添加物を含んでもよい。
In addition, the composition of the present invention is a sour agent such as citric acid, malic acid, fumaric acid, ascorbic acid, caramel dye, gardenia dye, anthocyanin dye, anato dye, paprika dye, safflower dye, safflower dye, flavonoid dye, cochineal Dye, Amaranth (Red No. 2), Erythrosine (Red No. 3), Allura Red AC (Red No. 40), New Coxin (Red No. 102), Phloxin (Red No. 104), Rose Bengal (Red No. 105), Acid Red (Red 106), Tartrazine (Yellow 4), Sunset Yellow FCF (Yellow 5), Fast Green FCF (Green 3), Brilliant Blue FCF (Blue 1), Indigo Carmine (Blue 2), etc. Can contain pigments, and oil-soluble bases such as carotene, chlorophyll, and tocopher Such Lumpur may contain harmless other additives to further human body.
本発明の組成物は、1回当たりの摂取量が好ましくは1~10グラム、より好ましくは1.5~5g、最も好ましくは2~3gとなるように、1回分が成形されていることが好ましい。形状は限定されず、板状、粒状、立方体、直方体、ボール状、その他の形状を上げることができ、成形された後に糖衣などでコーティングがなされてもよい。また、内部等に液体や固体の、別の組成物を含んでもよい。例えば、食感の面白さを付与する目的や風味を向上させる目的で、液体部分を含ませたり、キャンディやグミを含ませたりすることなどができる。なお、これらの別の組成物の重量は、本発明の組成物には含まない。
The composition of the present invention is preferably formed in a single dose so that the intake amount per time is preferably 1 to 10 grams, more preferably 1.5 to 5 g, and most preferably 2 to 3 g. preferable. The shape is not limited, and plate shape, granular shape, cube shape, rectangular parallelepiped shape, ball shape, and other shapes can be raised, and after forming, coating may be made with sugar coating or the like. Further, another composition such as a liquid or a solid may be contained in the inside or the like. For example, a liquid part can be included, or a candy or gummy can be included for the purpose of imparting an interesting texture or improving the flavor. The weight of these other compositions is not included in the composition of the present invention.
本発明の組成物は、食事制限を補助することが目的であるので、そのカロリーは低いことが望ましく、好ましくは本発明の組成物の1回の摂取量の熱量は0キロカロリーから12キロカロリー、より好ましくは0キロカロリーから3キロカロリーである。また、同様の理由により、本発明の組成物の1回の摂取量に含まれる糖質の量は0グラムから3グラムが好ましく、より好ましくは0グラムから1グラムである。
Since the composition of the present invention is intended to assist dietary restriction, it is desirable that the calories be low, and preferably the caloric intake of the composition of the present invention is from 0 to 12 kilocalories, more Preferably it is from 0 to 3 kilocalories. For the same reason, the amount of carbohydrate contained in one intake of the composition of the present invention is preferably 0 to 3 grams, more preferably 0 to 1 grams.
[実施例1]
グルコマンナン溶液の主観評価(1回目)
パネル10名(全員女性)に対し、グルコマンナン溶液の主観評価を実施した。対照溶液をシリンジで10ml量り、そのままパネルの口に注入し、摂取させた。その10分後に0.2%または0.4%のグルコマンナン溶液を対照溶液と同様に、同量である10mlをシリンジで量り、パネルの口へ注入し、摂取させた。摂取直後、パネルは表1の項目について、対照溶液と比較して主観評価した。結果を表2および3にまとめた。 [Example 1]
Subjective evaluation of glucomannan solution (first time)
A subjective evaluation of the glucomannan solution was performed on 10 panelists (all women). 10 ml of the control solution was weighed with a syringe and injected into the mouth of the panel as it was. Ten minutes later, a 0.2% or 0.4% glucomannan solution, like the control solution, was weighed in the same amount of 10 ml with a syringe and injected into the mouth of the panel to be ingested. Immediately after ingestion, the panel subjectively evaluated the items in Table 1 compared to the control solution. The results are summarized in Tables 2 and 3.
グルコマンナン溶液の主観評価(1回目)
パネル10名(全員女性)に対し、グルコマンナン溶液の主観評価を実施した。対照溶液をシリンジで10ml量り、そのままパネルの口に注入し、摂取させた。その10分後に0.2%または0.4%のグルコマンナン溶液を対照溶液と同様に、同量である10mlをシリンジで量り、パネルの口へ注入し、摂取させた。摂取直後、パネルは表1の項目について、対照溶液と比較して主観評価した。結果を表2および3にまとめた。 [Example 1]
Subjective evaluation of glucomannan solution (first time)
A subjective evaluation of the glucomannan solution was performed on 10 panelists (all women). 10 ml of the control solution was weighed with a syringe and injected into the mouth of the panel as it was. Ten minutes later, a 0.2% or 0.4% glucomannan solution, like the control solution, was weighed in the same amount of 10 ml with a syringe and injected into the mouth of the panel to be ingested. Immediately after ingestion, the panel subjectively evaluated the items in Table 1 compared to the control solution. The results are summarized in Tables 2 and 3.
なお、対照溶液と、グルコマンナン溶液はグルコマンナンと/あるいはマルチトールを水に溶解して調製した。組成は以下のとおりであった。
対照溶液:マルチトール2.0重量%
グルコマンナン溶液(0.2%):マルチトール2.0重量%、グルコマンナン0.2重量%
グルコマンナン溶液(0.4%):マルチトール2.0重量%、グルコマンナン0.4重量% The control solution and the glucomannan solution were prepared by dissolving glucomannan and / or maltitol in water. The composition was as follows:
Control solution: 2.0% by weight maltitol
Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt%
Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
対照溶液:マルチトール2.0重量%
グルコマンナン溶液(0.2%):マルチトール2.0重量%、グルコマンナン0.2重量%
グルコマンナン溶液(0.4%):マルチトール2.0重量%、グルコマンナン0.4重量% The control solution and the glucomannan solution were prepared by dissolving glucomannan and / or maltitol in water. The composition was as follows:
Control solution: 2.0% by weight maltitol
Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt%
Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
[実施例2]
グルコマンナン溶液の主観評価(2回目)
パネル12名(全員女性)に対し、グルコマンナン溶液の主観評価を実施した。パネルは評価前4時間の固形物の絶食をし、評価は空腹の状態で行った。なお、絶食時においても液体物の摂取については特に制限を行わなかった。 [Example 2]
Subjective evaluation of glucomannan solution (second time)
A subjective evaluation of the glucomannan solution was performed on 12 panelists (all women). The panel was fasted for 4 hours before evaluation and the evaluation was performed on an empty stomach. In addition, there was no particular restriction on the intake of liquids even during fasting.
グルコマンナン溶液の主観評価(2回目)
パネル12名(全員女性)に対し、グルコマンナン溶液の主観評価を実施した。パネルは評価前4時間の固形物の絶食をし、評価は空腹の状態で行った。なお、絶食時においても液体物の摂取については特に制限を行わなかった。 [Example 2]
Subjective evaluation of glucomannan solution (second time)
A subjective evaluation of the glucomannan solution was performed on 12 panelists (all women). The panel was fasted for 4 hours before evaluation and the evaluation was performed on an empty stomach. In addition, there was no particular restriction on the intake of liquids even during fasting.
評価は次のように行った。すなわち、対照溶液をシリンジで10ml量り、パネルの口へ注入し、摂取させた。その10分後に所定の濃度のグルコマンナン溶液を対照溶液と同様に、同量である10mlをシリンジで量り、パネルの口へ注入し、摂取させた。摂取直後にパネルは実施例1と同じ項目について、対照溶液と比較して主観評価を行った。また、さらに、摂取の順序を逆転して評価を行った。本実施例におけるタイムスケジュールを図1に示す。結果を表4~12にまとめた。
Evaluation was performed as follows. That is, 10 ml of the control solution was weighed with a syringe and injected into the mouth of the panel to ingest it. Ten minutes after that, similarly to the control solution, 10 ml of the same concentration of glucomannan solution was weighed with a syringe and injected into the mouth of the panel for ingestion. Immediately after ingestion, the panel performed a subjective evaluation on the same items as in Example 1 in comparison with the control solution. Further, the evaluation was performed by reversing the order of intake. The time schedule in the present embodiment is shown in FIG. The results are summarized in Tables 4-12.
なお、対照溶液と、グルコマンナン溶液はグルコマンナンと/あるいはマルチトールを水に溶解して調製した。組成は以下のとおりであった。
対照溶液:マルチトール2.0重量%
グルコマンナン溶液(0.2%):マルチトール2.0重量%、グルコマンナン0.2重量%
グルコマンナン溶液(0.3%):マルチトール2.0重量%、グルコマンナン0.3重量%
グルコマンナン溶液(0.4%):マルチトール2.0重量%、グルコマンナン0.4重量% The control solution and the glucomannan solution were prepared by dissolving glucomannan and / or maltitol in water. The composition was as follows:
Control solution: 2.0% by weight maltitol
Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt%
Glucomannan solution (0.3%): maltitol 2.0 wt%, glucomannan 0.3 wt%
Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
対照溶液:マルチトール2.0重量%
グルコマンナン溶液(0.2%):マルチトール2.0重量%、グルコマンナン0.2重量%
グルコマンナン溶液(0.3%):マルチトール2.0重量%、グルコマンナン0.3重量%
グルコマンナン溶液(0.4%):マルチトール2.0重量%、グルコマンナン0.4重量% The control solution and the glucomannan solution were prepared by dissolving glucomannan and / or maltitol in water. The composition was as follows:
Control solution: 2.0% by weight maltitol
Glucomannan solution (0.2%): maltitol 2.0 wt%, glucomannan 0.2 wt%
Glucomannan solution (0.3%): maltitol 2.0 wt%, glucomannan 0.3 wt%
Glucomannan solution (0.4%): 2.0% by weight maltitol, 0.4% by weight glucomannan
実施例1、2の結果より、グルコマンナン溶液を摂取した場合、グルコマンナンの濃度依存的に、「テクスチャー」「喉ごし」「胃に入った感じ」「胃に存在する感じ」の各評価項目で対照溶液を摂取した場合と比較して、パネルが違いを感じやすくなっている傾向にあった。また、対照溶液とグルコマンナン溶液の摂取順序による差は見られなかった。
グルコマンナン溶液は、対照溶液に比べ「胃に入った感じ」並びに「胃に存在する感じ」を強く感じさせることが分かった。その効果は濃度依存的と考えられる。 From the results of Examples 1 and 2, when the glucomannan solution was ingested, each evaluation of “texture”, “sore throat”, “feeling in the stomach”, and “feeling in the stomach” depending on the concentration of glucomannan. The panel tended to feel the difference more easily than when the control solution was ingested. Moreover, the difference by the intake order of a control solution and a glucomannan solution was not seen.
It was found that the glucomannan solution strongly felt “feeling in the stomach” and “feeling in the stomach” compared to the control solution. The effect is considered to be concentration dependent.
グルコマンナン溶液は、対照溶液に比べ「胃に入った感じ」並びに「胃に存在する感じ」を強く感じさせることが分かった。その効果は濃度依存的と考えられる。 From the results of Examples 1 and 2, when the glucomannan solution was ingested, each evaluation of “texture”, “sore throat”, “feeling in the stomach”, and “feeling in the stomach” depending on the concentration of glucomannan. The panel tended to feel the difference more easily than when the control solution was ingested. Moreover, the difference by the intake order of a control solution and a glucomannan solution was not seen.
It was found that the glucomannan solution strongly felt “feeling in the stomach” and “feeling in the stomach” compared to the control solution. The effect is considered to be concentration dependent.
[実施例3]
グルコマンナン配合ガムの作製
本発明の組成物の例として、以下のグルコマンナン配合ガムを作製した。製造方法は、通常のガムの製造方法に準じ、ガムベースと粉末原料、液体原料を50~60℃前後で混合した。グルコマンナンは、例えばレオレックス(商標)One(清水化学株式会社)などとして購入することができる。 [Example 3]
Production of Glucomannan Blending Gum The following glucomannan blending gum was produced as an example of the composition of the present invention. The production method was based on a normal gum production method, and a gum base, a powder raw material, and a liquid raw material were mixed at around 50 to 60 ° C. Glucomannan can be purchased as, for example, ROLEX (trademark) One (Shimizu Chemical Co., Ltd.).
グルコマンナン配合ガムの作製
本発明の組成物の例として、以下のグルコマンナン配合ガムを作製した。製造方法は、通常のガムの製造方法に準じ、ガムベースと粉末原料、液体原料を50~60℃前後で混合した。グルコマンナンは、例えばレオレックス(商標)One(清水化学株式会社)などとして購入することができる。 [Example 3]
Production of Glucomannan Blending Gum The following glucomannan blending gum was produced as an example of the composition of the present invention. The production method was based on a normal gum production method, and a gum base, a powder raw material, and a liquid raw material were mixed at around 50 to 60 ° C. Glucomannan can be purchased as, for example, ROLEX (trademark) One (Shimizu Chemical Co., Ltd.).
ガムベース 30.9 %
マンニトール 3.2 %
エリスリトール 20.6 %
マルチトール 30.9 %
還元パラチノース 3.4 %
グルコマンナン 2.4 %
還元麦芽糖水飴 1.7 %
33.3%アラビアガム水溶液 0.6 %
高甘味度甘味料 1.4 %
(アスパルテーム、アセスルファムカリウム)
酸味料 1.9 %
(クエン酸、リンゴ酸、フマル酸、アスコルビン酸)
色素 0.3 %
香料 2.8 %
100 %
(組成は重量%で示す) Gum base 30.9%
Mannitol 3.2%
Erythritol 20.6%
Maltitol 30.9%
Reduced palatinose 3.4%
Glucomannan 2.4%
Reduced maltose starch syrup 1.7%
33.3% gum arabic aqueous solution 0.6%
High intensity sweetener 1.4%
(Aspartame, acesulfame potassium)
Acidulant 1.9%
(Citric acid, malic acid, fumaric acid, ascorbic acid)
Dye 0.3%
Fragrance 2.8%
100%
(Composition is given in% by weight)
マンニトール 3.2 %
エリスリトール 20.6 %
マルチトール 30.9 %
還元パラチノース 3.4 %
グルコマンナン 2.4 %
還元麦芽糖水飴 1.7 %
33.3%アラビアガム水溶液 0.6 %
高甘味度甘味料 1.4 %
(アスパルテーム、アセスルファムカリウム)
酸味料 1.9 %
(クエン酸、リンゴ酸、フマル酸、アスコルビン酸)
色素 0.3 %
香料 2.8 %
100 %
(組成は重量%で示す) Gum base 30.9%
Mannitol 3.2%
Erythritol 20.6%
Maltitol 30.9%
Reduced palatinose 3.4%
Glucomannan 2.4%
Reduced maltose starch syrup 1.7%
33.3% gum arabic aqueous solution 0.6%
High intensity sweetener 1.4%
(Aspartame, acesulfame potassium)
Acidulant 1.9%
(Citric acid, malic acid, fumaric acid, ascorbic acid)
Dye 0.3%
Fragrance 2.8%
100%
(Composition is given in% by weight)
[実施例4]
グルコマンナン配合ガムを咀嚼した際の唾液量の測定
女性パネル3名(パネルA,B,C)が実施例3で製造したグルコマンナン配合ガム約2.1gを咀嚼し、分泌された唾液の重量を測定した。唾液を飲み込むタイミングで、試験管に吐出させ、その重量を測定した。試験管は1分おきに交換し、8分まで測定した。メトロノームのリズムに合わせて、1分間に80回のペースで咀嚼させた。結果を表13に示す。 [Example 4]
Measurement of the amount of saliva when chewing gum containing glucomannan The weight of saliva secreted by chewing about 2.1 g of glucomannan-containing gum produced by Example 3 by three female panels (panels A, B, C) Was measured. At the timing of swallowing saliva, it was discharged into a test tube and its weight was measured. The test tube was changed every 1 minute and measured up to 8 minutes. According to the rhythm of the metronome, it was chewed at a pace of 80 times per minute. The results are shown in Table 13.
グルコマンナン配合ガムを咀嚼した際の唾液量の測定
女性パネル3名(パネルA,B,C)が実施例3で製造したグルコマンナン配合ガム約2.1gを咀嚼し、分泌された唾液の重量を測定した。唾液を飲み込むタイミングで、試験管に吐出させ、その重量を測定した。試験管は1分おきに交換し、8分まで測定した。メトロノームのリズムに合わせて、1分間に80回のペースで咀嚼させた。結果を表13に示す。 [Example 4]
Measurement of the amount of saliva when chewing gum containing glucomannan The weight of saliva secreted by chewing about 2.1 g of glucomannan-containing gum produced by Example 3 by three female panels (panels A, B, C) Was measured. At the timing of swallowing saliva, it was discharged into a test tube and its weight was measured. The test tube was changed every 1 minute and measured up to 8 minutes. According to the rhythm of the metronome, it was chewed at a pace of 80 times per minute. The results are shown in Table 13.
[実施例5]
グルコマンナン配合ガムから溶出するグルコマンナン量の測定
実施例3で製造したグルコマンナン配合ガム2.1グラムをパネルが2分、3分、4分、5分、6分、7分、または8分メトロノームのリズムにあわせて1分間80回のペースで咀嚼し、咀嚼後のグルコマンナン配合ガムに残存するグルコマンナン量を測定し、配合量および、溶出率を算出した。対照として、咀嚼されないグルコマンナン配合ガムについても測定を行った。
測定方法は以下のとおりである。すなわち、咀嚼後あるいは対照のグルコマンナン配合ガムにトルエンを加え、分散させた後、水を加え沸騰状態で90分間加熱還流抽出し、水層を集めマンナン抽出液とした。マンナン抽出液に硫酸濃度が1.875 Nになるように濃硫酸を加え95℃5時間酸分解後、冷却し、中和(pH5~7)した。この溶液中のマンノースの定量を高速液体クロマトグラフィーにより行った。グルコマンナンを構成するグルコース:マンノースの比率は1:1.6であることから、得られたマンノース値に(1+1.6)/1.6を乗じてグルコマンナン量を求めた。 [Example 5]
Measurement of the amount of glucomannan eluted from the glucomannan-containing gum 2.1 grams of the glucomannan-containing gum produced in Example 3 is 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, or 8 minutes Mastication was performed at a pace of 80 times per minute according to the rhythm of the metronome, the amount of glucomannan remaining in the glucomannan-containing gum after chewing was measured, and the amount and dissolution rate were calculated. As a control, measurements were also made on a glucomannan-containing gum that was not chewed.
The measurement method is as follows. That is, after chewing or after adding toluene to the control glucomannan-containing gum and dispersing, water was added and the mixture was heated to reflux for 90 minutes in a boiling state, and the aqueous layer was collected to obtain a mannan extract. Concentrated sulfuric acid was added to the mannan extract so that the sulfuric acid concentration was 1.875 N, and the mixture was acid-decomposed at 95 ° C. for 5 hours, cooled, and neutralized (pH 5 to 7). The mannose in this solution was quantified by high performance liquid chromatography. Since the ratio of glucose: mannose constituting glucomannan was 1: 1.6, the amount of glucomannan was determined by multiplying the obtained mannose value by (1 + 1.6) /1.6.
グルコマンナン配合ガムから溶出するグルコマンナン量の測定
実施例3で製造したグルコマンナン配合ガム2.1グラムをパネルが2分、3分、4分、5分、6分、7分、または8分メトロノームのリズムにあわせて1分間80回のペースで咀嚼し、咀嚼後のグルコマンナン配合ガムに残存するグルコマンナン量を測定し、配合量および、溶出率を算出した。対照として、咀嚼されないグルコマンナン配合ガムについても測定を行った。
測定方法は以下のとおりである。すなわち、咀嚼後あるいは対照のグルコマンナン配合ガムにトルエンを加え、分散させた後、水を加え沸騰状態で90分間加熱還流抽出し、水層を集めマンナン抽出液とした。マンナン抽出液に硫酸濃度が1.875 Nになるように濃硫酸を加え95℃5時間酸分解後、冷却し、中和(pH5~7)した。この溶液中のマンノースの定量を高速液体クロマトグラフィーにより行った。グルコマンナンを構成するグルコース:マンノースの比率は1:1.6であることから、得られたマンノース値に(1+1.6)/1.6を乗じてグルコマンナン量を求めた。 [Example 5]
Measurement of the amount of glucomannan eluted from the glucomannan-containing gum 2.1 grams of the glucomannan-containing gum produced in Example 3 is 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, or 8 minutes Mastication was performed at a pace of 80 times per minute according to the rhythm of the metronome, the amount of glucomannan remaining in the glucomannan-containing gum after chewing was measured, and the amount and dissolution rate were calculated. As a control, measurements were also made on a glucomannan-containing gum that was not chewed.
The measurement method is as follows. That is, after chewing or after adding toluene to the control glucomannan-containing gum and dispersing, water was added and the mixture was heated to reflux for 90 minutes in a boiling state, and the aqueous layer was collected to obtain a mannan extract. Concentrated sulfuric acid was added to the mannan extract so that the sulfuric acid concentration was 1.875 N, and the mixture was acid-decomposed at 95 ° C. for 5 hours, cooled, and neutralized (
なお、高速液体クロマトグラフィーの条件は以下の通りである。
装置:ダイオネクス社 液体クロマトグラフィー ICS-3000 カラム:CarboPac PA-1(4×250mm)
ガードカラム: CarboPac PA-1(4×50mm) 溶離液:水酸化ナトリウム150mM 検出:電気化学検出器
溶液流速:1.0ml / min The conditions for high performance liquid chromatography are as follows.
Equipment: Liquid chromatography ICS-3000 Column: CarboPac PA-1 (4 × 250 mm)
Guard column: CarboPac PA-1 (4 × 50 mm) Eluent: Sodium hydroxide 150 mM Detection: Electrochemical detector Solution flow rate: 1.0 ml / min
装置:ダイオネクス社 液体クロマトグラフィー ICS-3000 カラム:CarboPac PA-1(4×250mm)
ガードカラム: CarboPac PA-1(4×50mm) 溶離液:水酸化ナトリウム150mM 検出:電気化学検出器
溶液流速:1.0ml / min The conditions for high performance liquid chromatography are as follows.
Equipment: Liquid chromatography ICS-3000 Column: CarboPac PA-1 (4 × 250 mm)
Guard column: CarboPac PA-1 (4 × 50 mm) Eluent: Sodium hydroxide 150 mM Detection: Electrochemical detector Solution flow rate: 1.0 ml / min
結果は表14のとおりであった。なお、表に示される数値は、それぞれの時間の咀嚼後のグルコマンナン配合ガムにおけるグルコマンナンの溶出率である。
なお、グルコマンナン配合ガムのグルコマンナンの配合量は、本方法の分析によると2.19%と求められた。 The results are shown in Table 14. In addition, the numerical value shown by a table | surface is the elution rate of the glucomannan in the glucomannan combination gum after chewing of each time.
In addition, according to the analysis of this method, the blending amount of glucomannan in the glucomannan blended gum was determined to be 2.19%.
なお、グルコマンナン配合ガムのグルコマンナンの配合量は、本方法の分析によると2.19%と求められた。 The results are shown in Table 14. In addition, the numerical value shown by a table | surface is the elution rate of the glucomannan in the glucomannan combination gum after chewing of each time.
In addition, according to the analysis of this method, the blending amount of glucomannan in the glucomannan blended gum was determined to be 2.19%.
咀嚼に伴い、グルコマンナン配合ガム中のグルコマンナンが徐々に減少したことがわかる。
It can be seen that glucomannan in the glucomannan-containing gum gradually decreased with chewing.
実施例4、5の結果より、2.1gのグルコマンナン配合ガムを5分間咀嚼すると、10gの唾液にグルコマンナンが90%程度(2.1g×2.19%×90%=約0.04g)溶出し、飲み込まれることで胃に入ることが分かった。つまり、2.1gのグルコマンナン配合ガムを5分間咀嚼すると、0.4%グルコマンナンを含む唾液を10g飲み込むこととなり、実施例1、2で最も効果が認められたグルコマンナン摂取量と同じとなる。すなわち、2.1gのグルコマンナン配合ガムを5分間咀嚼すると、グルコマンナンを含む唾液を飲み込むことによって、胃に入った感じ、並びに胃に存在する感じを強く知覚できる、ということが示唆される。
From the results of Examples 4 and 5, 2.1 g of glucomannan-containing gum was chewed for 5 minutes, and 10 g of saliva was about 90% glucomannan (2.1 g × 2.19% × 90% = about 0.04 g). ) Elution and swallowing was found to enter the stomach. That is, when chewing 2.1 g of glucomannan-containing gum for 5 minutes, 10 g of saliva containing 0.4% glucomannan is swallowed, which is the same as the amount of glucomannan intake most effective in Examples 1 and 2. Become. That is, when chewing 2.1 g of glucomannan-containing gum for 5 minutes, it is suggested that the feeling of entering the stomach and the feeling of existing in the stomach can be strongly perceived by swallowing saliva containing glucomannan.
[実施例6]
グルコマンナン配合ガムを咀嚼した際の主観評価
男性パネル6名(パネル1~6)および女性パネル6名(パネル7~12)に対し、実施例3で製造したグルコマンナン配合ガム約2.1g、もしくは対照ガム約2.1gを7分間咀嚼させた。咀嚼方法については、特に指定しなかった。なお、ここで使用する対照ガムは、実施例3のグルコマンナン配合ガムにおいて、配合中のグルコマンナン2.4%をマルチトール2.4%に置換したものである。
咀嚼させた時間帯は、空腹感を感じやすいと考えられる午前11時~12時および午後4時~5時とした。すなわち、グルコマンナン配合ガムもしくは対照ガムのうちどちらか一方を午前11時~12時に咀嚼させて評価を行い、午後4時~5時にもう一方を咀嚼させて評価を行った。評価については、図2に示す評価軸を用い、「コバラが紛れた」感じの強さ、について10段階で主観評価を行った。なお、「コバラが紛れた」とは、「空腹感が緩和した」状況のことを指す。結果を表15から表17に示す。 [Example 6]
Subjective evaluation when chewing glucomannan-containing gum About 2.1 g of glucomannan-containing gum produced in Example 3 for 6 male panels (panels 1-6) and 6 female panels (panels 7-12), Alternatively, about 2.1 g of control gum was chewed for 7 minutes. The chewing method was not specified. In addition, the control gum used here is obtained by substituting 2.4% of glucomannan in the blended glucomannan of Example 3 with 2.4% of maltitol.
The chewing hours were 11:00 am to 12:00 am and 4 pm to 5:00 pm, which are thought to make it easy to feel hungry. That is, one of the glucomannan-containing gum and the control gum was chewed for evaluation from 11:00 to 12:00, and the other was chewed for evaluation from 4 to 5 pm. For the evaluation, the evaluation axis shown in FIG. 2 was used, and the subjective evaluation was carried out in 10 stages with respect to the strength of the feeling of “cobala was lost”. “Cobala was lost” refers to a situation where “feeling of hunger has eased”. The results are shown in Table 15 to Table 17.
グルコマンナン配合ガムを咀嚼した際の主観評価
男性パネル6名(パネル1~6)および女性パネル6名(パネル7~12)に対し、実施例3で製造したグルコマンナン配合ガム約2.1g、もしくは対照ガム約2.1gを7分間咀嚼させた。咀嚼方法については、特に指定しなかった。なお、ここで使用する対照ガムは、実施例3のグルコマンナン配合ガムにおいて、配合中のグルコマンナン2.4%をマルチトール2.4%に置換したものである。
咀嚼させた時間帯は、空腹感を感じやすいと考えられる午前11時~12時および午後4時~5時とした。すなわち、グルコマンナン配合ガムもしくは対照ガムのうちどちらか一方を午前11時~12時に咀嚼させて評価を行い、午後4時~5時にもう一方を咀嚼させて評価を行った。評価については、図2に示す評価軸を用い、「コバラが紛れた」感じの強さ、について10段階で主観評価を行った。なお、「コバラが紛れた」とは、「空腹感が緩和した」状況のことを指す。結果を表15から表17に示す。 [Example 6]
Subjective evaluation when chewing glucomannan-containing gum About 2.1 g of glucomannan-containing gum produced in Example 3 for 6 male panels (panels 1-6) and 6 female panels (panels 7-12), Alternatively, about 2.1 g of control gum was chewed for 7 minutes. The chewing method was not specified. In addition, the control gum used here is obtained by substituting 2.4% of glucomannan in the blended glucomannan of Example 3 with 2.4% of maltitol.
The chewing hours were 11:00 am to 12:00 am and 4 pm to 5:00 pm, which are thought to make it easy to feel hungry. That is, one of the glucomannan-containing gum and the control gum was chewed for evaluation from 11:00 to 12:00, and the other was chewed for evaluation from 4 to 5 pm. For the evaluation, the evaluation axis shown in FIG. 2 was used, and the subjective evaluation was carried out in 10 stages with respect to the strength of the feeling of “cobala was lost”. “Cobala was lost” refers to a situation where “feeling of hunger has eased”. The results are shown in Table 15 to Table 17.
表15から表17より、パネル1および3を除き、対照ガム咀嚼時よりもグルコマンナン配合ガム咀嚼時の方が、コバラが紛れたとの主観評価点が高い傾向が見られた。主観評価点の平均を見ても、対照ガム咀嚼時よりもグルコマンナン配合ガム咀嚼時の方が高かった。主観評価点の平均について、対応のあるt検定による有意差判定を行った結果、p=0.000518<0.05(有意水準)との結果であった。
従って、グルコマンナンを配合したガムを咀嚼することで、グルコマンナンを配合しないガムを咀嚼した場合よりも有意に「コバラが紛れた」感じ、すなわち空腹感が緩和した感じが高くなることが示された。 From Table 15 to Table 17, except for panels 1 and 3, a tendency was found that the subjective evaluation score that Kobara was lost was higher when chewing gum with glucomannan was chewing than when chewing gum. Looking at the average subjective evaluation score, it was higher when chewing gum with glucomannan than when chewing gum. As a result of carrying out a significant difference determination by the corresponding t-test with respect to the average of the subjective evaluation points, the result was p = 0.000518 <0.05 (significance level).
Therefore, chewing gum containing glucomannan shows that the feeling of “cobala is lost” significantly, that is, the feeling of hunger is relaxed, is higher than when chewing gum without glucomannan. It was.
従って、グルコマンナンを配合したガムを咀嚼することで、グルコマンナンを配合しないガムを咀嚼した場合よりも有意に「コバラが紛れた」感じ、すなわち空腹感が緩和した感じが高くなることが示された。 From Table 15 to Table 17, except for
Therefore, chewing gum containing glucomannan shows that the feeling of “cobala is lost” significantly, that is, the feeling of hunger is relaxed, is higher than when chewing gum without glucomannan. It was.
この出願は2012年10月9日に出願された日本国特許出願第2012-224145号からの優先権を主張するものであり、その内容を引用してこの出願の一部とするものである。
This application claims priority from Japanese Patent Application No. 2012-224145 filed on Oct. 9, 2012, the contents of which are incorporated herein by reference.
Claims (4)
- グルコマンナンとガムベースを含み、咀嚼されることで空腹感を緩和することを特徴とする組成物。 A composition comprising glucomannan and a gum base, which is chewed to relieve hunger.
- グルコマンナンが1~10重量%の割合で含有されることを特徴とする請求項1に記載の組成物。 2. The composition according to claim 1, wherein glucomannan is contained in an amount of 1 to 10% by weight.
- 1個あたり1~10gに成形されていることを特徴とする請求項1または2に記載の組成物。 3. The composition according to claim 1, wherein the composition is molded to 1 to 10 g per piece.
- 1個あたりグルコマンナンの量が0.01~1gとなるように成形されたことを特徴とする請求項1から3のいずれかに記載の組成物。
4. The composition according to claim 1, wherein the composition is molded so that the amount of glucomannan per unit is 0.01 to 1 g.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201380052781.2A CN104703488A (en) | 2012-10-09 | 2013-10-04 | Composition for alleviating hunger sensation |
KR1020157011728A KR20150065851A (en) | 2012-10-09 | 2013-10-04 | Composition for alleviating hunger sensation |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012224145A JP2014075984A (en) | 2012-10-09 | 2012-10-09 | Composition for alleviating hunger |
JP2012-224145 | 2012-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2014057637A1 true WO2014057637A1 (en) | 2014-04-17 |
Family
ID=50477121
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2013/005922 WO2014057637A1 (en) | 2012-10-09 | 2013-10-04 | Composition for alleviating hunger sensation |
Country Status (5)
Country | Link |
---|---|
JP (1) | JP2014075984A (en) |
KR (1) | KR20150065851A (en) |
CN (1) | CN104703488A (en) |
TW (1) | TW201438592A (en) |
WO (1) | WO2014057637A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD796775S1 (en) | 2015-09-09 | 2017-09-12 | Intercontinental Great Brands Llc | Confection |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04502704A (en) * | 1989-01-19 | 1992-05-21 | ディコファルム エスピーエィ | Composition of biscuit-like diet food with high dietary fiber content and low calorie content and method for producing the same |
JP2001095492A (en) * | 1999-09-29 | 2001-04-10 | Kanebo Ltd | Stick-preventing agent and non-sticky viscoelastic food |
JP2005224150A (en) * | 2004-02-12 | 2005-08-25 | Belluna Co Ltd | Overeating prevention food |
JP2007508329A (en) * | 2003-10-17 | 2007-04-05 | ダイエット・フォーミュレイションズ・リミテッド | Weight loss supplements |
WO2008001800A1 (en) * | 2006-06-28 | 2008-01-03 | Otsuka Pharmaceutical Co., Ltd. | Tooth enamel dissolution inhibitor |
JP2008510491A (en) * | 2004-08-25 | 2008-04-10 | キャドバリー・アダムズ・ユーエスエイ・エルエルシー | Liquid filled chewing gum composition |
-
2012
- 2012-10-09 JP JP2012224145A patent/JP2014075984A/en active Pending
-
2013
- 2013-10-04 CN CN201380052781.2A patent/CN104703488A/en active Pending
- 2013-10-04 WO PCT/JP2013/005922 patent/WO2014057637A1/en active Application Filing
- 2013-10-04 KR KR1020157011728A patent/KR20150065851A/en not_active Application Discontinuation
- 2013-10-08 TW TW102136353A patent/TW201438592A/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH04502704A (en) * | 1989-01-19 | 1992-05-21 | ディコファルム エスピーエィ | Composition of biscuit-like diet food with high dietary fiber content and low calorie content and method for producing the same |
JP2001095492A (en) * | 1999-09-29 | 2001-04-10 | Kanebo Ltd | Stick-preventing agent and non-sticky viscoelastic food |
JP2007508329A (en) * | 2003-10-17 | 2007-04-05 | ダイエット・フォーミュレイションズ・リミテッド | Weight loss supplements |
JP2005224150A (en) * | 2004-02-12 | 2005-08-25 | Belluna Co Ltd | Overeating prevention food |
JP2008510491A (en) * | 2004-08-25 | 2008-04-10 | キャドバリー・アダムズ・ユーエスエイ・エルエルシー | Liquid filled chewing gum composition |
WO2008001800A1 (en) * | 2006-06-28 | 2008-01-03 | Otsuka Pharmaceutical Co., Ltd. | Tooth enamel dissolution inhibitor |
Non-Patent Citations (2)
Title |
---|
"Kande Hajikete Fukurande, Onaka Manzoku! ''Kobara Pitari Gum'' Shin Hatsubai!", KRACIE FOODS KABUSHIKI KAISHA NEWS RELEASE, 29 January 2009 (2009-01-29), Retrieved from the Internet <URL:http://www.kracie.co.jp/release/pdf/0901> [retrieved on 20131115] * |
YUKI YABUSHITA ET AL.: "Glucomannan Suiyoeki Sesshu ni yoru Kufukukan Kanwa Sayo eno Eikyo", KENKO - EIYO SHOKUHIN KENKYU, vol. 14, no. 2, 10 April 2013 (2013-04-10), pages 1 - 6 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD796775S1 (en) | 2015-09-09 | 2017-09-12 | Intercontinental Great Brands Llc | Confection |
USD822333S1 (en) | 2015-09-09 | 2018-07-10 | Intercontinental Great Brands Llc | Confection |
USD843681S1 (en) | 2015-09-09 | 2019-03-26 | Intercontinental Great Brands Llc | Confection |
USD874087S1 (en) | 2015-09-09 | 2020-02-04 | Intercontinental Great Brands Llc | Confection |
Also Published As
Publication number | Publication date |
---|---|
JP2014075984A (en) | 2014-05-01 |
KR20150065851A (en) | 2015-06-15 |
TW201438592A (en) | 2014-10-16 |
CN104703488A (en) | 2015-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2455974C2 (en) | Product for oral cavity care and chewing gum (versions) | |
CN109640703A (en) | Composition and production and preparation method thereof for mental alertness | |
WO1993020718A1 (en) | Food composition which inhibits formation of intestinal putrefaction product | |
TWI603680B (en) | Mixture of spice extract oral composition | |
JP6351929B2 (en) | Oral composition for reducing hypersensitivity | |
JP3390438B2 (en) | Psyllium drink mix composition containing granular base | |
CN108813626A (en) | A kind of compound probiotic chewing soft capsule of tooth-whitening | |
CN103635096B (en) | Encapsulated acid, its preparation method and include the chewing gum of described encapsulated acid | |
WO2014057637A1 (en) | Composition for alleviating hunger sensation | |
SA08290496B1 (en) | Flavoured therapeutic composition based on clay | |
CN105120829B (en) | Cleaning composition in oral cavity | |
JP5110033B2 (en) | Soft candy | |
CN105211480A (en) | Tasty and refreshing sugar of a kind of prebiotics agate card sugar-free and preparation method thereof | |
JPH0638707A (en) | Food composition for suppressing formation of decomposed product in intestine | |
WO2014010244A1 (en) | Food composition with improved flavor persistence | |
JP6133037B2 (en) | Porous food and method for producing the same | |
BR112020006437A2 (en) | methods of preparing steviol glycosides and their uses | |
JP7536948B2 (en) | Oral composition, method for improving sweetness aftertaste, and method for inhibiting discoloration | |
BR112019020076A2 (en) | soft candy | |
JP6918606B2 (en) | Sustained release composition of water-soluble substances | |
KR101582982B1 (en) | Gum composition maintaining flavor and taste | |
JP2022174474A (en) | solid composition | |
JP6234786B2 (en) | Chewing gum | |
TW202222168A (en) | Gum for chewing training, and chewing training using same | |
JP2022083890A (en) | Solid |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 13845477 Country of ref document: EP Kind code of ref document: A1 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
ENP | Entry into the national phase |
Ref document number: 20157011728 Country of ref document: KR Kind code of ref document: A |
|
122 | Ep: pct application non-entry in european phase |
Ref document number: 13845477 Country of ref document: EP Kind code of ref document: A1 |