CN105106777A

CN105106777A - Drug for treating hepatitis B and preparation method thereof

Info

Publication number: CN105106777A
Application number: CN201510586817.6A
Authority: CN
Inventors: 宋克垣
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-09-16
Filing date: 2015-09-16
Publication date: 2015-12-02

Abstract

The invention discloses a drug for treating hepatitis B and a preparation method thereof. The drug for treating the hepatitis B is mainly prepared from roots of Chinese thorowax, scutellaria baicalensis, Japanese knotweeds, glabrous greenbrier rhizomes, silkworm excrement, a spreading hedyotis herb, hawthorns, Chinese taxillus twigs, cimicifuga foetida, Chinese rhubarb, radix scrophulariae and a Chinese sage herb in certain weight proportion. The drug for treating the hepatitis B has the functions of clearing heat, promoting dieresis, achieving detoxication and toxicant elimination, reducing phlegm and stasis, promoting blood circulation to remove meridian obstruction, enriching yin and nourishing kidney, is used for treating the hepatitis B and is fast in effect and good in treating effect, and the hepatitis B does not relapse.

Description

A kind of medicine for the treatment of hepatitis B and preparation method thereof

Technical field

The present invention relates to a kind of medicine for the treatment of hepatitis B and preparation method thereof, belong to the field of Chinese medicines.

Background technology

Hepatitis B is caused by hepatitis B virus (HBV), based on liver inflammatory pathological changes, and can cause a kind of disease of multiple organ injury.The traditional Chinese medical science then thinks the heresy due to epidemic disease caused by damp-heat pathogen poison, and has very strong infectiousness.Because the side effect of western medicine hepatitis B is large, therefore there is great demand to the Chinese medicine of effectively treating hepatitis B in people, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The present inventor, through development test repeatedly, finally have found the medicine of effectively treatment hepatitis B, thus completes the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment hepatitis B.

Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.

Medicine of the present invention selects Radix Bupleuri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Bombyx mori L., Herba Hedyotidis Diffusae, Fructus Crataegi, Herba Taxilli, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Salviae Chinensis, Fructus Lycii, Flos Chrysanthemi medicine to carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat hepatitis B.Wherein select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Select Radix Scutellariae to be because its nature and flavor bitter cold, enter cardiopulmonary, gallbladder, large intestine channel, have removing the relative excess fire, except damp and hot, the function of arresting bleeding and miscarriage prevention, controls high fever excessive thirst, cough due to lung-heat.Select Rhizoma Polygoni Cuspidati to be because its nature and flavor are bitter, flat, dispel the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis ， lumps in the chest and abdomen, anal fistula hematochezia, injury from falling down, scalds, malignant boil tinea disease.Select Rhizoma Smilacis Glabrae to be because its property slightly sweet flavor, flat, enter liver, stomach warp, have removing toxic substances, dehumidifying, the function in sharp joint, controls syphilis, stranguria with turbid discharge, muscles and bones spasm and pain, beriberi, furuncle, carbuncle, scrofula.Select Bombyx mori L. to be that return liver, spleen channel, have expelling wind and removing dampness, the function of analgesic therapy of invigorating blood circulation, dispelling the wind and dampness pathogens arthralgia pain, joint is unsuccessful, waist foot cold type of pain, rubella pruritus because its nature and flavor are sweet, pungent, warm, wind syndrome of head is had a headache, marginal blepharitis eye.Select Herba Hedyotidis Diffusae to be because its property bitter but sweet flavor, cold, enter the heart, liver, spleen three warp, have heat clearing away, dampness removing, the function of removing toxic substances, controls dyspnea and cough due to lung-heat, tonsillitis, pharyngolaryngitis, appendicitis, dysentery, jaundice, pelvic inflammatory disease, adnexitis, carbuncle furuncle, venom.Select Fructus Crataegi be because its nature and flavor acid sweet, tepor, enters spleen, stomach, Liver Channel, have help digestion long-pending, dissipating blood stasis blood, taenifugal function, controls meat Ji ， mass in the abdomen, phlegm retention, feeling of fullness, acid regurgitation, dysentery, hemorrhoidal hamorrhage, lumbago, hernia, puerperal after-pains, lochiorrhea, children's breast food stagnate.Select Herba Taxilli to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, except rheumatism, the meridian dredging, beneficial blood, antiabortive function, controls soreness of waist and knee joint, and muscles and bones flaccidity is weak, hemiplegia, beriberi, anemofrigid-damp arthralgia, vaginal bleeding during pregnancy metrorrhagia, lack of lactation after delivery.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Radix Et Rhizoma Rhei is selected to be that enter stomach, large intestine, liver footpath, have the poison that purges heat, removing mass is stagnant because its nature and flavor are bitter, cold, the function of clots absorbing blood, control excess-heat constipation, delirium is gone mad, food stagnation feeling of fullness, dysentery from the beginning of, tenesmus, stasis of blood menolipsis Bi ， lumps in the chest and abdomen, time row epidemic disease due to heat pathogen, sudden and violent swelling ophthalmalgia, spits blood, epistaxis, YANG jaundice, edema, stranguria with turbid discharge, urinates red, carbuncle and ulcer toxic swelling, furuncle, burn.Select Radix Scrophulariae to be because its nature and flavor are bitter, salty, cool, enter lung, kidney channel, have YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances, control calentura excessive thirst, send out speckle, hectic fever due to YIN-deficiency consumptive fever, sleep night not peaceful, spontaneous sweating, constipation is hindered in Tianjin, hematemesis and epistaxis, laryngopharynx swelling and pain, carbuncle, scrofula.Herba Salviae Chinensis is selected to be because its nature and flavor are bitter, pungent, flat, control dysphagic, phlegm dyspnea, hepatitis, red and white leukorrhea, carbuncle, scrofula.Fructus Lycii is selected to be that flat, have nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, and cough due to consumptive disease, quenches one's thirst because its nature and flavor are sweet, seminal emission.Flos Chrysanthemi is selected to be that cool, enter lung, Liver Channel, have dispelling wind, disappear heat, improving eyesight, and the function of removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling because its nature and flavor sweetness and bitterness.

Detailed description of the invention

The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:

Radix Bupleuri 100-150 gram, Radix Scutellariae 120-160 gram, Rhizoma Polygoni Cuspidati 250-350 gram, Rhizoma Smilacis Glabrae 250-350 gram, Bombyx mori L. 280-320 gram, Herba Hedyotidis Diffusae 280-320 gram, Fructus Crataegi 250-350 gram, Herba Taxilli 120-180 gram, Rhizoma Cimicifugae 120-160 gram, Radix Et Rhizoma Rhei 45-55 gram, Radix Scrophulariae 120-180 gram, Herba Salviae Chinensis 280-320 gram, Fructus Lycii 120-160 gram, Flos Chrysanthemi 120-160 gram.

Be preferably:

Radix Bupleuri 120 grams, Radix Scutellariae 150 grams, Rhizoma Polygoni Cuspidati 300 grams, Rhizoma Smilacis Glabrae 300 grams, Bombyx mori L. 300 grams, Herba Hedyotidis Diffusae 300 grams, Fructus Crataegi 300 grams, Herba Taxilli 150 grams, Rhizoma Cimicifugae 150 grams, Radix Et Rhizoma Rhei 50 grams, Radix Scrophulariae 150 grams, Herba Salviae Chinensis 300 grams, Fructus Lycii 150 grams, Flos Chrysanthemi 150 grams.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Radix Bupleuri: get crude drug, removes residual stem, impurity, cleans, softens, cut sheet, dry, and sieve removes chip;

2, Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and run through rear section and dry, attention is avoided tanning by the sun excessively rubescent;

3, Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;

4, Rhizoma Smilacis Glabrae: with water logging drift, change water every day in summer 1 time, spring, every 2 days of autumn change water 1 time, and 3 days winters changed water 1 time, prevented smelly, till soaking, pulled section out, dry in time;

5, Bombyx mori L.: removing impurity, sieve dedust bits;

6, Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;

7, Fructus Crataegi: pick clean impurity, sieve enucleation;

8, Herba Taxilli: wash, runs through, and cutting is dried;

9, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

10, Radix Et Rhizoma Rhei: get the Radix Et Rhizoma Rhei be cut into small pieces, mix thoroughly with yellow wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, and taking-up is dried, Radix Et Rhizoma Rhei block 100 jin, with yellow wine 40 jin;

11, Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

12, Herba Salviae Chinensis: get crude drug, removing impurity, cleans, slightly moistens, cutting, dry;

13, Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;

14, Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity.

Two, prepare

1, the preparation of medicament capsule of the present invention:

(1) Radix Bupleuri cooked, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Bombyx mori L., Herba Hedyotidis Diffusae, Fructus Crataegi, Herba Taxilli, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Salviae Chinensis, Fructus Lycii, Flos Chrysanthemi are put into decocting container and decocted with water secondary, wherein Bombyx mori L. loads cloth bag, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

(3) dry extract is broken into powder, incapsulates, every 0.5g.

2, the preparation of medicinal granule of the present invention:

(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.

3, the preparation of medicinal tablet of the present invention:

(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every sheet 0.5g.

4, the preparation of medicine honeyed pill of the present invention:

(1) by cook Radix Bupleuri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Bombyx mori L., Herba Hedyotidis Diffusae, Fructus Crataegi, Herba Taxilli, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Salviae Chinensis, Fructus Lycii, Flos Chrysanthemi mixing and stirring, porphyrize powder crosses 200 order dusting covers;

(2) Mel is refined into the tender honey of 110-115 DEG C;

(3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball is containing pure medicine 1.5 grams.

In prescription, Herba Hedyotidis Diffusae has heat clearing away, dampness removing, removing toxic substances function be monarch drug; Radix Et Rhizoma Rhei purges heat poison, and removing mass is stagnant, clots absorbing blood; Rhizoma Polygoni Cuspidati dispels the wind, dampness removing, removing blood stasis with potent drugs, the function of stimulating the menstrual flow, the two is ministerial drug, and three taste medicines play YIN nourishing jointly, moisturize, heat clearing away, the effect of pathogenic fire purging, treatment hepatitis B effect is comprehensive, and with nourishing YIN to lower pathogenic fire, heat-clearing and toxic substances removing is that master can be effected a permanent cure, and Radix Scrophulariae has YIN nourishing, pathogenic fire reducing, relieving restlessness, the function of removing toxic substances is adjuvant drug, Radix Bupleuri reconciling superficies and interior, soothing the liver, yang invigorating is for making medicine, and all medicines take stopgap measures with being left.

Medicine of the present invention has clearing away heat-damp and promoting diuresis, and the function of detoxication and toxicant eliminating function, Huatan Zhuyu, promoting blood circulation to remove obstruction in the collateral, enriching yin and nourishing kidney, is used for the treatment of hepatitis B, short treating period, instant effect, non-relapse after healing.

Detailed description of the invention:

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples comprise animal toxicity test report and the clinical observation on the therapeutic effect data of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention:

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.5kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group oral capsule, a kind of dosage form in granule or tablet is 0.2g/kg, and normal amount is 0.1g/kg, administering mode is the administration of dilution administration by gavage, twice daily, serve on 7 days, observe administration reaction every day, result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept Hepatitis B Clinic patient totally 36 examples for medical treatment.

2, diagnostic criteria

(1) because of liver function damage, patient often feels weak, is short of physical strength, lower limb or hydrosarca, easily tired, can not beat spirit, the symptoms such as insomnia, dreaminess.A few peoples also have flu-like symptoms;

(2) because bile secretion reduces, often there is inappetence, feel sick, detest the significantly symptom such as oil, epigastric discomfort, abdominal distention in patient;

(3) because blood mesobilirubin concentration increases, patient there will be jaundice, skin, urine jaundice, and urine is the symptoms such as Umber;

(4) when hepatitis B worsens, there is the symptoms such as upper right abdomen, RHC discomfort, dull pain in patient;

(5) due to inflammation, hyperemia, edema, cholestasis, patient often has the symptoms such as liver enlargement;

(6) palm surface of many patients can be congested rubescent, and the nameless second articulations digitorum manus facies palmaris of two handss has obvious tenderness sense;

(7) due to endocrine disturbance, patient's dim complexion or pitch-dark, claims hepatic facies, skin also there will be spider angioma etc.

3, Therapeutic Method

Select above-mentioned medicament to take to patient, each serving with capsule or granule or 4 grams, tablet or honeyed pill 6 ball, every day is early, middle and late respectively takes 1 time, within 10 days, is a course for the treatment of, takes 3 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: hepatitis B symptom disappears, body constitution recovers normal, recovery from illness;

Take a turn for the better: patient's abdominal distention, edema, jaundice phenomenon alleviate, and hepatitis B symptom is clearly better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy hepatitis B patient 36 example of the present invention, effective 33 examples of result, obvious effective rate is 91.67%, and take a turn for the better 2 examples, and improvement rate is 5.56, and invalid 1 example, total effective rate is 97.22%.

Claims

1. treat a medicine for hepatitis B, it is characterized in that: it is made up of the crude drug in following weight range:

2. medicine according to claim 1, wherein the consumption of each crude drug is:

3. the preparation method of medicine according to claim 1 or 2, it comprises the following steps:

(1) get the raw materials ready

(1) Radix Bupleuri: get crude drug, removes residual stem, impurity, cleans, softens, cut sheet, dry, and sieve removes chip;

(2) Radix Scutellariae: pick decontamination, removes residual stem, infiltrates or put in boiled water slightly to soak to pull out with cold water, and run through rear section and dry, attention is avoided tanning by the sun excessively rubescent;

(3) Rhizoma Polygoni Cuspidati: adopt after, smooth file, dries;

(4) Rhizoma Smilacis Glabrae: with water logging drift, change water every day in summer 1 time, spring, every 2 days of autumn change water 1 time, and 3 days winters changed water 1 time, prevented smelly, till soaking, pulled section out, dry in time;

(5) Bombyx mori L.: removing impurity, sieve dedust bits;

(6) Herba Hedyotidis Diffusae: get crude drug, removing impurity, wash quickly is clean, slightly dries in the air, cutting, dry, sieve dedust bits;

(7) Fructus Crataegi: pick clean impurity, sieve enucleation;

(8) Herba Taxilli: wash, runs through, and cutting is dried;

(9) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

(10) Radix Et Rhizoma Rhei: get the Radix Et Rhizoma Rhei be cut into small pieces, mix thoroughly with yellow wine, put in food steamer and steam, or put sealing in tank, sit in kettle, Steam by water bath is saturating, and taking-up is dried, Radix Et Rhizoma Rhei block 100 jin, with yellow wine 40 jin;

(11) Radix Scrophulariae: pick clean impurity, except removing LU, clean and run through, section, dries;

(12) Herba Salviae Chinensis: get crude drug, removing impurity, cleans, slightly moistens, cutting, dry;

(13) Fructus Lycii: clean impurity of winnowing with a dustpan, plucks residual stalk and the base of a fruit;

(14) Flos Chrysanthemi: pick clean leaf stalk, anthocaulus and spare impurity;

(2) prepare

(1) preparation of medicament capsule of the present invention:

1. the Radix Bupleuri cooked, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Bombyx mori L., Herba Hedyotidis Diffusae, Fructus Crataegi, Herba Taxilli, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Salviae Chinensis, Fructus Lycii, Flos Chrysanthemi are put into decocting container and decocted with water secondary, wherein Bombyx mori L. loads cloth bag, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;

2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;

3. dry extract is broken into powder, incapsulates;

(2) preparation of medicinal granule of the present invention:

3. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;

(3) preparation of medicinal tablet of the present invention:

3. dry extract is broken into fine powder, adds adjuvant and make granule, tabletted;

(4) preparation of medicine honeyed pill of the present invention:

1. by cook Radix Bupleuri, Radix Scutellariae, Rhizoma Polygoni Cuspidati, Rhizoma Smilacis Glabrae, Bombyx mori L., Herba Hedyotidis Diffusae, Fructus Crataegi, Herba Taxilli, Rhizoma Cimicifugae, Radix Et Rhizoma Rhei, Radix Scrophulariae, Herba Salviae Chinensis, Fructus Lycii, Flos Chrysanthemi mixing and stirring, porphyrize powder crosses 200 order dusting covers;

2. Mel is refined into the tender honey of 110-115 DEG C;

3. by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball is containing pure medicine 1.5 grams.