CN105106648A - Traditional Chinese medicine composition for treating cough variant asthma - Google Patents

Abstract

The invention discloses a traditional Chinese medicine composition for treating cough variant asthma. According to the traditional Chinese medicine, it is thought that a syndrome of lung dryness due to yin deficiency is important pathogenesis in the occurrence and development process of the cough variant asthma. According to the pathogenesis, the traditional Chinese medicine composition for treating the cough variant asthma is prepared from traditional Chinese medicines of discolor ludisia herbs, mountain oreas herbs, Siberian milkwort roots, bornet cowlily rhizome, ovateleaf coelogyne herbs, dragons tongue leaves, axillaryflower twistedstalk roots, common coltsfoot flowers, Japanese platanthera herbs, common nepenthes and perny holly roots, and the raw materials are prepared to be decoction through a department of pharmaceutical preparations of the hospital. According to clinic trials, the total effective rate reaches 95 percent and is significantly superior to a control group. It is verified through experiments that the traditional Chinese medicine composition has obvious effects on aspects of improving clinical symptoms of a CVA patient and mitigating the disease.

Description

A kind of Chinese medicine composition for the treatment of cough variant asthma

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine composition for the treatment of cough variant asthma.

Background technology

Cough variant asthma (Coughvariantasthma, CVA) is a kind of asthma of specific type, and cough is its unique or main clinical manifestation, and has airway hyperreactivity.Main manifestations is zest dry cough, and nocturnal cough is its key character.Flu, cold air, dust, oil smoke etc. easily bring out or increase the weight of cough.If give effective treatment not in time, some patients can develop into typical asthma.In treatment, doctor trained in Western medicine is mainly based on bronchodilator and glucocorticoid.In traditional Chinese medical science tradition book, completely not corresponding with cough variant asthma name of disease, from the generation of this disease, develop the clinical syndrome characteristics analysis shown, many doctors are mostly belonged to dry cough, stupidly to be coughed, wind is coughed, chronic cough, cough referring to the heart various disease category.Inventor is in clinical practice for many years, and application theory of Chinese medical science, this is sick to adopt treatment by Chinese herbs, and not only have received good effect, and side effect is little, treatment cost is low.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine composition for the treatment of cough variant asthma.The traditional Chinese medical science thinks that syndrome of lung dryness due to yin deficiency is that pathogenesis important in evolution occurs CVA.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine composition of this treatment cough variant asthma is made up of the Chinese medicine of following weight portion: Herba Ludisiae Discoloris 3-9 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 12-15 part, Radix Polygalae sibiricae 9-15 part, Rhizoma Nupharis Bornetii 30-40 part, Herba Coelogynes 6-9 part, Flos Sauropi changiani leaf 6-15 part, Radix Streptopi Simplicis 9-15 part, Flos Farfarae 5-9 part, Herba Platantherae Japonicae 9-15 part, Herba nepenthis 15-25 part, Radix Ilicis Pernyi 9-15 part.

Preferably, Herba Ludisiae Discoloris 6 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 13.5 parts, Radix Polygalae sibiricae 12 parts, Rhizoma Nupharis Bornetii 35 parts, Herba Coelogynes 7.5 parts, Flos Sauropi changiani leaf 11 parts, Radix Streptopi Simplicis 12 parts, Flos Farfarae 7 parts, Herba Platantherae Japonicae 12 parts, Herba nepenthis 20 parts, Radix Ilicis Pernyi 12 parts.

Preparation method decocting makes Chinese medicine decoction.

Fang Zhong: Herba Ludisiae Discoloris nourishing YIN and moistening the lung, clearing away heat and cooling blood; Oreas martiana (Hopp. Et Hornsch.) Brid. replenishing YIN and removing heat, tranquilizing the mind, expelling wind and removing dampness, hemostatic analgesia; Radix Polygalae sibiricae nourishing YIN and clearing away heat, detoxify, eliminate the phlegm; Rhizoma Nupharis Bornetii nourishing YIN and clearing away heat; Herba Coelogynes tonifying-Yin and nourishing-stomach, promoting the production of body fluid to quench thirst; Flos Sauropi changiani leaf nourishing the lung to arrest cough; Radix Streptopi Simplicis clearing and antitussive; Flos Farfarae nourishing the lung to keep the adverse QI downward, preventing phlegm from forming and stopping coughing; Herba Platantherae Japonicae lung moistening, expelling phlegm for arresting cough; Herba nepenthis moistens dryness and relieve cough, heat clearing away row water, removing toxic substances; Radix Ilicis Pernyi nourishing the lung to arrest cough, heat-clearing and toxic substances removing.

Clinical data

1, physical data object of study is from my Out-patient Department and inpatient in June ,-2013 in June, 2010.Adopt SAS software to produce random table to carry out dividing into groups (taking date as seed number, SAS random process is adopted to produce), 80 routine MethodsThe cases enrolled are divided into two groups, treatment by Chinese herbs group (observation group) 40 example, wherein female 21 example, man 19 example, mean age is 41.6 years old, the course of disease is the shortest 8 weeks, the longest 2.1 years, average 0.51 year; Western medicine group (matched group) 40 example, wherein female 19 example, man 21 example, the mean age is 39.5 years old, and the course of disease is the shortest 10 weeks, the longest 2 years, average 0.43 year.Two groups of patients in sex, age, the course of disease difference through statistical procedures, P > 0.05, not statistically significant.

2, diagnostic criteria Western medicine diagnose standard: " the Clinics and Practices guide (draft) of cough " standard according to Chinese medical respirology branch asthma group formulation in 2005: 1. chronic cough is often with obvious night or irritable cough in early morning; 2. brinchial provocation test is positive, Bronchodilatation test is positive or maximal expiratory flow (PEF) round the clock different rate be greater than 20%; 3. bronchodilator, glucocorticoid treatment are effective; 4. the chronic cough that other reasons causes is got rid of.

Tcm syndrome standard, with reference to " new Chinese medicine Linchuan research guideline " and " practical internal medicine ", determines that the clinical manifestation of lung-dryness syndrome due to deficiency of YIN disease is as follows: cough, and dry pharynx pharynx is overworked or choke and cough battle array and do, cough very then nausea, the factors such as hoarseness or uncomfortable in chest out of breath, meets hot and cold air, abnormal flavour happen suddenly or increase the weight of, or night crouch to rise morning and cough play, many outbreaks in repeatability, dry cough without phlegm or few expectorant, red tongue tongue is white or yellow, dry few Tianjin, stringy and rolling pulse or stringy and thready pulse.

1. inclusive criteria meets the Western medicine diagnose standard of cough variant asthma; 2. Chinese medical discrimination is syndrome of lung dryness due to yin deficiency; 3. age 18-65 year.

Excluded cases standard is serious respiratory system disease 1., as chronic obstructive pulmonary disease, pulmonary carcinoma, pulmonary tuberculosis etc.; 2. the age is greater than 65 years old and is less than 18 years old person; 3. gestation or women breast-feeding their children, or prepare gestation women 4. psychotic, mismatch experimenter.

3, Therapeutic Method observation group: take compositions in Chinese medicine of the present invention, prescription: take Herba Ludisiae Discoloris 6g, Oreas martiana (Hopp. Et Hornsch.) Brid. 13.5g, Radix Polygalae sibiricae 12g, Rhizoma Nupharis Bornetii 35g, Herba Coelogynes 7.5g, Flos Sauropi changiani leaf 11g, Radix Streptopi Simplicis 12g, Flos Farfarae 7g, Herba Platantherae Japonicae 12g, Herba nepenthis 20g, Radix Ilicis Pernyi 12g.Decocting makes decoction oral, once a day.Matched group: Meptin (Procaterol Hydrochloride), 25ug/ time, every day twice, all treating for two groups 14 days is a course for the treatment of.

4, criterion of therapeutical effect efficacy evaluation safety indexes: 1. general physical examination; 2. tested front and back blood, routine urinalysis; 3. tested front and back electrocardiogram, liver function (ALT, AST), renal function (BUN, CREA).

Health giving quality index clinical symptoms, sign and picture of the tongue, pulse condition.Especially the change of CF, degree is noted, as following table:

Efficacy evaluation is according to symptom and sign ranking criterion, and criterion is as follows: 1. clinic control: after treatment, symptom and sign disappear substantially; 2. effective: after treatment, symptom integral declines two integration stages, cough number of times and cough degree by 9 points transfer to 3 points or by 6 points transfer to 0 point 3. effective: after treatment, symptom integral declines an integration stages, cough number of times and cough degree transfer 6 points or transfer 3 points to by 6 points to by 9 points, or transfer 0 point to by 3 points).4. invalid: after treatment, symptom and sign is without taking a turn for the better or increasing the weight of.

5. therapeutic outcome observation group patient 40 example, clinic control 24 example (60%), effective 8 examples (20%), effective 6 examples (15%), invalid 2 examples (5%).Total effective rate is 95%; Matched group patient 40 example, clinic control 16 example (40%), effective 12 examples (30%), effective 6 examples (15%), invalid 10 examples (25%).Total effective rate is 75%.This result of study shows, marking after two groups of patient treatments is all improved, and the curative effect of observation group is higher than matched group.This Chinese medicine composition is for improving CVA patient clinical symptom, and the effect of mitigate the disease aspect is obvious.

Detailed description of the invention

Embodiment one: take Herba Ludisiae Discoloris 6g, Oreas martiana (Hopp. Et Hornsch.) Brid. 13.5g, Radix Polygalae sibiricae 12g, Rhizoma Nupharis Bornetii 35g, Herba Coelogynes 7.5g, Flos Sauropi changiani leaf 11g, Radix Streptopi Simplicis 12g, Flos Farfarae 7g, Herba Platantherae Japonicae 12g, Herba nepenthis 20g, Radix Ilicis Pernyi 12g, decocting makes decoction oral, once a day.

Embodiment two: take Herba Ludisiae Discoloris 9g, Oreas martiana (Hopp. Et Hornsch.) Brid. 12g, Radix Polygalae sibiricae 15g, Rhizoma Nupharis Bornetii 30g, Herba Coelogynes 9g, Flos Sauropi changiani leaf 6g, Radix Streptopi Simplicis 15g, Flos Farfarae 5g, Herba Platantherae Japonicae 15g, Herba nepenthis 15g, Radix Ilicis Pernyi 15g, decocting makes decoction oral, once a day.

Embodiment three: take Herba Ludisiae Discoloris 3g, Oreas martiana (Hopp. Et Hornsch.) Brid. 15g, Radix Polygalae sibiricae 9g, Rhizoma Nupharis Bornetii 40g, Herba Coelogynes 6g, Flos Sauropi changiani leaf 15g, Radix Streptopi Simplicis 9g, Flos Farfarae 9g, Herba Platantherae Japonicae 9g, Herba nepenthis 25g, Radix Ilicis Pernyi 9g, decocting makes decoction oral, once a day.

Claims (2)

1. treat a Chinese medicine composition for cough variant asthma, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Herba Ludisiae Discoloris 3-9 part, Oreas martiana (Hopp. Et Hornsch.) Brid. 12-15 part, Radix Polygalae sibiricae 9-15 part, Rhizoma Nupharis Bornetii 30-40 part, Herba Coelogynes 6-9 part, Flos Sauropi changiani leaf 6-15 part, Radix Streptopi Simplicis 9-15 part, Flos Farfarae 5-9 part, Herba Platantherae Japonicae 9-15 part, Herba nepenthis 15-25 part, Radix Ilicis Pernyi 9-15 part.

2. a kind of Chinese medicine composition for the treatment of cough variant asthma as claimed in claim 1, it is characterized in that this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Herba Ludisiae Discoloris 6 parts, Oreas martiana (Hopp. Et Hornsch.) Brid. 13.5 parts, Radix Polygalae sibiricae 12 parts, Rhizoma Nupharis Bornetii 35 parts, Herba Coelogynes 7.5 parts, Flos Sauropi changiani leaf 11 parts, Radix Streptopi Simplicis 12 parts, Flos Farfarae 7 parts, Herba Platantherae Japonicae 12 parts, Herba nepenthis 20 parts, Radix Ilicis Pernyi 12 parts.