CN105104761A - Method for preparing enramycin premix - Google Patents
Method for preparing enramycin premix Download PDFInfo
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- CN105104761A CN105104761A CN201510570363.3A CN201510570363A CN105104761A CN 105104761 A CN105104761 A CN 105104761A CN 201510570363 A CN201510570363 A CN 201510570363A CN 105104761 A CN105104761 A CN 105104761A
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- enramycin
- zymotic fluid
- premix
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- preprocess method
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
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Abstract
The invention discloses a method for preparing enramycin premix. The method comprises the steps that the temperature of enramycin fermentation liquor is firstly increased to 70-75 DEG C, then complex antioxidants of which the mass accounts for 0.5-1.0% of that of the enramycin fermentation liquor and filter aid of which the mass accounts for 0-12% of that of the enramycin fermentation liquor are added, and the mixture is stirred fully and evenly; frame filter and flash drying are performed on the evenly stirred mixture, auxiliary materials are added in the mixture for dilution, and then the enramycin premix is prepared. The method is simple, easy to operate and low in cost, and compared with finished enramycin premix which is not preprocessed, the enramycin premix has the advantages that the degradation degree is obviously weakened and the stability is obviously improved.
Description
Technical field
The present invention relates to drug world, specifically a kind of method preparing enramycin premix.
Background technology
Enramycin (enramycin) has another name called enramycin, enramycin, Enramycin, enramycin, fermented by actinomyces (Streptomycesfungicidicus) and obtain, it is the polypeptide antibiotics that unrighted acid is combined with tens seed amino acids, key component has enramycin A and B, is the application of its hydrochloride form.Researched and developed by Japanese Takede Chemical Industries Ltd in 1966 at first.Within 1974, at Japanese official register, be registered and extensive use in many countries thereafter.The Ministry of Agriculture of China in 1993 ratifies this medicine and registers in China, and registration enramycin premix (grace draws ancient cooking vessel) by name, as medicated feed additive.2000, Japanese Wu Tian Animal Health Care Products Corporation of Schering Plough corporate buyout, this product produced operation without competition by Schering Plough, domestic market is in monopolization state.Haizheng Medicine Stock Co., Ltd., Zhejiang Prov of domestic production enterprise in 2005 and Schering Plough animal health-care product Co., Ltd of the U.S. start to cooperate, and produce enramycin premix, and its output and sales volume account for the whole world 80%.2009, it reached 200,000,000 yuans in the sales volume of China, and sales volume is in the trend progressively risen.Enramycin has very strong inhibitory action to gram-positive bacteria, Long-Time Service not easily produces drug resistance, and can change the bacterial community distribution in enteron aisle, is conducive to digesting and assimilating of feed nutrient, promote animal weightening finish and improve efficiency of feed utilization, and noresidue in livestock and poultry body.Effect in Production of Livestock and Poultry is remarkable.Therefore, by many countries in the world as antibiotic growth accelerator.
Although enramycin has good development prospect at home and abroad, but due to the unstability of enramycin premix product, place content after a period of time can degrade to some extent, affect the stability of enramycin in storage, transportation, and then have impact on its quality and sale and use.
Summary of the invention
The object of the present invention is to provide a kind of method preparing enramycin premix that palliating degradation degree obviously weakens, stability significantly improves, to solve the problem proposed in above-mentioned background technology.
For achieving the above object, the invention provides following technical scheme:
A kind of method preparing enramycin premix, concrete steps are: the enramycin zymotic fluid fermented is warming up to 70-75 DEG C, then add the composite antioxidant of the 0.5-1.0% of enramycin zymotic fluid quality, and the filter aid adding the 0-12% of enramycin zymotic fluid quality stirs; Treat fully to stir evenly laggard row plate-frame filtering, expansion drying, add the obtained enramycin premix of auxiliary material dilution.
As the further scheme of the present invention: composite antioxidant is aluminum sulfate, D-araboascorbic acid sodium and vitamin E, and the mass ratio of aluminum sulfate, D-araboascorbic acid sodium and vitamin E is 2:1:1.
As the further scheme of the present invention: filter aid is coarse whiting, perlite or diatomite.
As the further scheme of the present invention: enramycin zymotic fluid is the zymotic fluid obtained for strain fermentation with cabicidin streptomycete (Streptomycesfungicidicus).
As the further scheme of the present invention: the pressure of plate-frame filtering is 0.4-0.6mPa, and time of filter pressing is 1-3h, and gassing time is 0.5-1.0h.
As the further scheme of the present invention: expansion drying EAT is 90-150 DEG C, leaving air temp is 60-90 DEG C.
As the further scheme of the present invention: auxiliary material is powdered rice hulls or corn flour.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention mainly by carrying out pretreatment to the zymotic fluid of enramycin, thus changes the stability of enramycin premix finished product, and make enramycin finished product more stable in storage, transport and application process, convenient, quality is guaranteed.The present invention is simple, cost is low, and does not carry out compared with pretreated finished product, and the palliating degradation degree of finished product obviously weakens, and stability significantly improves.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
The present invention is directed to the problem of enramycin premix finished product stability difference, provide a kind of method preparing enramycin premix.Preprocess method of the present invention is simple, cost is low, pollution-free, the enramycin premix finished product palliating degradation degree obtained by the method process is obviously weakened, and stability significantly improves.More stable, convenient in storage transport and application process.Concrete is described below described in embodiment.
Embodiment 1
In the embodiment of the present invention, get the enramycin zymotic fluid that 2 batch fermentations complete, process as follows:
Control group: do not do pretreatment, is undertaken by existing technique.
Experimental group: carry out pretreatment by the inventive method, then (pressure is 0.4-0.6mPa to carry out plate-frame filtering to 2 batch fermentation liquid at identical conditions, time of filter pressing is 1-3h), filter cake carries out expansion drying (EAT is 90-150 DEG C, and leaving air temp is 60-90 DEG C).Obtain enramycin mycelium after drying, regulate it to tire by adding auxiliary material (powdered rice hulls or corn flour), be uniformly mixed, obtain enramycin premix finished product, every assembly system 3 batches compares.The finished product prepared, after stability test case stores a period of time, detects the content of enramycin in sample.Enramycin premix stability test data are in shown in Table 1-2.Manufacturer: Shijiazhuang high-tech animal health-care product Co., Ltd, storage requirement: temperature (25 ± 2) DEG C, humidity (60 ± 5) %.
Table 1
Table 2
By table 1 and table 2 comparative analysis known, it is better than not carrying out pretreated finished product stability to carry out its stability of pretreated finished product.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or essential characteristic, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (7)
1. prepare the method for enramycin premix for one kind, it is characterized in that, concrete steps are: the enramycin zymotic fluid fermented is warming up to 70-75 DEG C, then add the composite antioxidant of the 0.5-1.0% of enramycin zymotic fluid quality, and the filter aid adding the 0-12% of enramycin zymotic fluid quality stirs; Treat fully to stir evenly laggard row plate-frame filtering, expansion drying, add the obtained enramycin premix of auxiliary material dilution.
2. the preprocess method of enramycin zymotic fluid according to claim 1, is characterized in that, composite antioxidant is aluminum sulfate, D-araboascorbic acid sodium and vitamin E, and the mass ratio of aluminum sulfate, D-araboascorbic acid sodium and vitamin E is 2:1:1.
3. the preprocess method of enramycin zymotic fluid according to claim 1, is characterized in that, filter aid is coarse whiting, perlite or diatomite.
4. the preprocess method of enramycin zymotic fluid according to claim 1, is characterized in that, enramycin zymotic fluid is the zymotic fluid obtained for strain fermentation with cabicidin streptomycete.
5. the preprocess method of enramycin zymotic fluid according to claim 1 is for the preparation of the method for enramycin premix, it is characterized in that, the pressure of plate-frame filtering is 0.4-0.6mPa, and time of filter pressing is 1-3h, and gassing time is 0.5-1.0h.
6. the preprocess method of enramycin zymotic fluid according to claim 1 is for the preparation of the method for enramycin premix, it is characterized in that, expansion drying EAT is 90-150 DEG C, and leaving air temp is 60-90 DEG C.
7. the preprocess method of enramycin zymotic fluid according to claim 1 is for the preparation of the method for enramycin premix, it is characterized in that, auxiliary material is powdered rice hulls or corn flour.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510570363.3A CN105104761A (en) | 2015-09-09 | 2015-09-09 | Method for preparing enramycin premix |
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| CN201510570363.3A CN105104761A (en) | 2015-09-09 | 2015-09-09 | Method for preparing enramycin premix |
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| CN201510570363.3A Pending CN105104761A (en) | 2015-09-09 | 2015-09-09 | Method for preparing enramycin premix |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999220A (en) * | 2016-06-30 | 2016-10-12 | 石家庄高科动物保健品有限公司 | Preparation method of enramycin premixing agent |
| CN108059657A (en) * | 2018-01-18 | 2018-05-22 | 山西新源华康化工股份有限公司 | Production process for preventing enramycin product from degrading |
| CN108187027A (en) * | 2018-03-30 | 2018-06-22 | 内蒙古拜克生物有限公司 | A kind of enramycin premix and preparation method thereof |
| CN108543060A (en) * | 2018-03-30 | 2018-09-18 | 内蒙古拜克生物有限公司 | A method of improving enramycin premix stability |
| CN113797315A (en) * | 2021-11-08 | 2021-12-17 | 石家庄高科动物保健品有限公司 | Method for improving degradation resistance of enramycin premix |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102633865A (en) * | 2012-04-24 | 2012-08-15 | 山东胜利生物工程有限公司 | Method for pretreating enramycin fermentation liquor and method for preparing enramycin premix by using enramycin fermentation liquor |
| CN103230582A (en) * | 2013-04-17 | 2013-08-07 | 南京工业大学 | Preparation method of duramycin premix |
-
2015
- 2015-09-09 CN CN201510570363.3A patent/CN105104761A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102633865A (en) * | 2012-04-24 | 2012-08-15 | 山东胜利生物工程有限公司 | Method for pretreating enramycin fermentation liquor and method for preparing enramycin premix by using enramycin fermentation liquor |
| CN103230582A (en) * | 2013-04-17 | 2013-08-07 | 南京工业大学 | Preparation method of duramycin premix |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105999220A (en) * | 2016-06-30 | 2016-10-12 | 石家庄高科动物保健品有限公司 | Preparation method of enramycin premixing agent |
| CN105999220B (en) * | 2016-06-30 | 2023-06-09 | 石家庄高科动物保健品有限公司 | Preparation method of enramycin premix |
| CN108059657A (en) * | 2018-01-18 | 2018-05-22 | 山西新源华康化工股份有限公司 | Production process for preventing enramycin product from degrading |
| CN108187027A (en) * | 2018-03-30 | 2018-06-22 | 内蒙古拜克生物有限公司 | A kind of enramycin premix and preparation method thereof |
| CN108543060A (en) * | 2018-03-30 | 2018-09-18 | 内蒙古拜克生物有限公司 | A method of improving enramycin premix stability |
| CN113797315A (en) * | 2021-11-08 | 2021-12-17 | 石家庄高科动物保健品有限公司 | Method for improving degradation resistance of enramycin premix |
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Application publication date: 20151202 |