CN105085649B - 使用包含cmp或酪蛋白种类的给料分离骨桥蛋白的方法 - Google Patents
使用包含cmp或酪蛋白种类的给料分离骨桥蛋白的方法 Download PDFInfo
- Publication number
- CN105085649B CN105085649B CN201510434329.3A CN201510434329A CN105085649B CN 105085649 B CN105085649 B CN 105085649B CN 201510434329 A CN201510434329 A CN 201510434329A CN 105085649 B CN105085649 B CN 105085649B
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- cream
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- 238000000034 method Methods 0.000 title claims abstract 33
- 102000004264 Osteopontin Human genes 0.000 title claims abstract 6
- 108010081689 Osteopontin Proteins 0.000 title claims abstract 6
- 239000005018 casein Substances 0.000 title claims abstract 3
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 title claims abstract 3
- 235000021240 caseins Nutrition 0.000 title claims abstract 3
- 238000000926 separation method Methods 0.000 title abstract 2
- 210000002966 serum Anatomy 0.000 claims abstract 28
- 239000006071 cream Substances 0.000 claims abstract 25
- 102000011632 Caseins Human genes 0.000 claims abstract 5
- 108010076119 Caseins Proteins 0.000 claims abstract 5
- 235000021247 β-casein Nutrition 0.000 claims abstract 2
- 235000018102 proteins Nutrition 0.000 claims 11
- 102000004169 proteins and genes Human genes 0.000 claims 11
- 108090000623 proteins and genes Proteins 0.000 claims 11
- 239000007790 solid phase Substances 0.000 claims 5
- 102000004407 Lactalbumin Human genes 0.000 claims 3
- 108090000942 Lactalbumin Proteins 0.000 claims 3
- 239000001888 Peptone Substances 0.000 claims 3
- 108010080698 Peptones Proteins 0.000 claims 3
- 125000000129 anionic group Chemical group 0.000 claims 3
- 235000019319 peptone Nutrition 0.000 claims 3
- 235000021241 α-lactalbumin Nutrition 0.000 claims 3
- 102000008192 Lactoglobulins Human genes 0.000 claims 2
- 108010060630 Lactoglobulins Proteins 0.000 claims 2
- 238000005349 anion exchange Methods 0.000 claims 2
- 150000004676 glycans Chemical class 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 238000004064 recycling Methods 0.000 claims 2
- 239000013049 sediment Substances 0.000 claims 2
- 229920000936 Agarose Polymers 0.000 claims 1
- 108010001441 Phosphopeptides Proteins 0.000 claims 1
- 238000005571 anion exchange chromatography Methods 0.000 claims 1
- 150000001450 anions Chemical class 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 238000011026 diafiltration Methods 0.000 claims 1
- 238000001704 evaporation Methods 0.000 claims 1
- 230000008020 evaporation Effects 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 125000003010 ionic group Chemical group 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000002407 reforming Methods 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 238000001694 spray drying Methods 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 235000021249 α-casein Nutrition 0.000 claims 1
- 239000005862 Whey Substances 0.000 abstract 1
- 102000007544 Whey Proteins Human genes 0.000 abstract 1
- 108010046377 Whey Proteins Proteins 0.000 abstract 1
- 235000009508 confectionery Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
- A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
- A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Peptides Or Proteins (AREA)
- Dairy Products (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Fodder In General (AREA)
- Feed For Specific Animals (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161448775P | 2011-03-03 | 2011-03-03 | |
| EP11156826 | 2011-03-03 | ||
| EP11156826.7 | 2011-03-03 | ||
| US61/448,775 | 2011-03-03 | ||
| CN201280015495.4A CN103492408B (zh) | 2011-03-03 | 2012-03-05 | 使用包含cmp或酪蛋白种类的给料来分离骨桥蛋白的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280015495.4A Division CN103492408B (zh) | 2011-03-03 | 2012-03-05 | 使用包含cmp或酪蛋白种类的给料来分离骨桥蛋白的方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105085649A CN105085649A (zh) | 2015-11-25 |
| CN105085649B true CN105085649B (zh) | 2019-08-16 |
Family
ID=44202290
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280015375.4A Active CN103476787B (zh) | 2011-03-03 | 2012-03-05 | 用于使用浓缩给料分离骨桥蛋白的方法 |
| CN201510434329.3A Active CN105085649B (zh) | 2011-03-03 | 2012-03-05 | 使用包含cmp或酪蛋白种类的给料分离骨桥蛋白的方法 |
| CN201280015495.4A Active CN103492408B (zh) | 2011-03-03 | 2012-03-05 | 使用包含cmp或酪蛋白种类的给料来分离骨桥蛋白的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280015375.4A Active CN103476787B (zh) | 2011-03-03 | 2012-03-05 | 用于使用浓缩给料分离骨桥蛋白的方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280015495.4A Active CN103492408B (zh) | 2011-03-03 | 2012-03-05 | 使用包含cmp或酪蛋白种类的给料来分离骨桥蛋白的方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9181325B2 (enExample) |
| EP (2) | EP2681231B1 (enExample) |
| JP (2) | JP6012053B2 (enExample) |
| KR (2) | KR101940829B1 (enExample) |
| CN (3) | CN103476787B (enExample) |
| AR (2) | AR085620A1 (enExample) |
| AU (2) | AU2012222313B2 (enExample) |
| BR (2) | BR112013022251B1 (enExample) |
| CA (2) | CA2828746C (enExample) |
| DK (2) | DK2681231T3 (enExample) |
| EA (2) | EA023367B1 (enExample) |
| ES (2) | ES2565380T3 (enExample) |
| MX (2) | MX2013010017A (enExample) |
| PL (2) | PL2681230T3 (enExample) |
| WO (2) | WO2012117119A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014519796A (ja) * | 2011-04-28 | 2014-08-14 | ゾール サーキュレイション インコーポレイテッド | バッテリー管理パラメータの拡散型配布 |
| JP2015516949A (ja) | 2012-03-28 | 2015-06-18 | アーラ フーズ エエムビエＡｒｌａ Ｆｏｏｄｓ ａｍｂａ | オステオポンチンとカルシウムおよび／またはストロンチウム含有粒子とを含有するナノ粒子凝集体 |
| WO2015001092A1 (en) * | 2013-07-05 | 2015-01-08 | Arla Foods Amba | Mammalian milk osteopontin for enhancing immune responsiveness |
| US9661868B2 (en) * | 2013-07-16 | 2017-05-30 | Mead Johnson Nutrition Company | Expanded bed adsorption methods for isolation of basic milk proteins including lactoferrin |
| KR200482960Y1 (ko) | 2016-04-07 | 2017-03-21 | 오숙희 | 고주파 얼굴 축소 시술기 |
| CA3030022A1 (en) * | 2016-07-06 | 2018-01-11 | Building Block Nutritionals, Llc | Nutritional formula |
| EP3538053A1 (en) | 2016-11-08 | 2019-09-18 | Dentherapy Ltd | Compositions comprising fluoride and calcium and method for preparing them |
| EP3727032A1 (en) * | 2017-12-22 | 2020-10-28 | Société des Produits Nestlé S.A. | Extracts and their use |
| CN109613140B (zh) * | 2019-01-07 | 2021-10-08 | 雅士利国际集团有限公司 | 食品中酪蛋白磷酸肽的检测方法 |
| WO2021257543A1 (en) | 2020-06-15 | 2021-12-23 | Building Block Nutritionals, Llc | Nutritional formula |
| GB202010987D0 (en) | 2020-07-16 | 2020-09-02 | Dentherapy Ltd | Oral care compositions and methods |
| EP4326076A1 (en) * | 2021-04-19 | 2024-02-28 | Société des Produits Nestlé S.A. | Use of milk protein fractions as a source of osteopontin |
| CN113567573B (zh) * | 2021-07-09 | 2023-06-02 | 黑龙江飞鹤乳业有限公司 | 骨桥蛋白的分离方法和分析方法 |
| GB202110114D0 (en) | 2021-07-14 | 2021-08-25 | Dentherapy Ltd | Oral care compositions for use in treaatment |
| EP4587455A1 (en) | 2022-09-16 | 2025-07-23 | Univerza V Ljubljani | Isolation of osteopontin and glycomacropeptide from whey |
| WO2025008636A1 (en) | 2023-07-06 | 2025-01-09 | Dentherapy Ltd | Oral care compositions for use in the treatment of dental health conditions |
| CN117837766A (zh) * | 2023-12-27 | 2024-04-09 | 美维仕(北京)健康管理有限公司 | 营养组合物及其应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU712430B2 (en) * | 1996-10-01 | 1999-11-04 | Massey University | Process for isolating high purity glycomacropeptide from dairy products |
| WO1999033415A1 (en) | 1997-12-31 | 1999-07-08 | Depuy Orthopaedics, Inc. | Osteopontin-based compositions for enhancing bone repair |
| US6489447B1 (en) * | 1998-05-06 | 2002-12-03 | Genentech, Inc. | Protein purification |
| US7018665B2 (en) * | 1999-12-08 | 2006-03-28 | Massey University | Process for separation of whey proteins using a novel anion exchanger |
| PT1244702E (pt) * | 2000-01-07 | 2006-08-31 | Arla Foods Amba | Processo para o isolamento da osteopontina do leite |
| NZ507335A (en) | 2000-10-05 | 2004-10-29 | New Zealand Dairy Board | Bone health compositions derived from milk comprising an acidic protein fraction but that does not contain CGMP |
-
2012
- 2012-03-05 WO PCT/EP2012/053748 patent/WO2012117119A1/en not_active Ceased
- 2012-03-05 EA EA201391203A patent/EA023367B1/ru not_active IP Right Cessation
- 2012-03-05 CN CN201280015375.4A patent/CN103476787B/zh active Active
- 2012-03-05 JP JP2013555901A patent/JP6012053B2/ja active Active
- 2012-03-05 KR KR1020137026174A patent/KR101940829B1/ko active Active
- 2012-03-05 MX MX2013010017A patent/MX2013010017A/es active IP Right Grant
- 2012-03-05 DK DK12707103.3T patent/DK2681231T3/en active
- 2012-03-05 KR KR1020137026175A patent/KR101940830B1/ko active Active
- 2012-03-05 AU AU2012222313A patent/AU2012222313B2/en active Active
- 2012-03-05 PL PL12706623T patent/PL2681230T3/pl unknown
- 2012-03-05 CA CA2828746A patent/CA2828746C/en active Active
- 2012-03-05 ES ES12707103.3T patent/ES2565380T3/es active Active
- 2012-03-05 CA CA2828669A patent/CA2828669C/en active Active
- 2012-03-05 EP EP12707103.3A patent/EP2681231B1/en active Active
- 2012-03-05 CN CN201510434329.3A patent/CN105085649B/zh active Active
- 2012-03-05 PL PL12707103T patent/PL2681231T3/pl unknown
- 2012-03-05 US US14/002,614 patent/US9181325B2/en active Active
- 2012-03-05 WO PCT/EP2012/053749 patent/WO2012117120A1/en not_active Ceased
- 2012-03-05 BR BR112013022251-4A patent/BR112013022251B1/pt active IP Right Grant
- 2012-03-05 EA EA201391204A patent/EA023615B1/ru not_active IP Right Cessation
- 2012-03-05 CN CN201280015495.4A patent/CN103492408B/zh active Active
- 2012-03-05 ES ES12706623.1T patent/ES2565379T3/es active Active
- 2012-03-05 DK DK12706623.1T patent/DK2681230T3/en active
- 2012-03-05 US US14/002,578 patent/US9181316B2/en active Active
- 2012-03-05 MX MX2013010019A patent/MX2013010019A/es active IP Right Grant
- 2012-03-05 AU AU2012222312A patent/AU2012222312B2/en active Active
- 2012-03-05 EP EP12706623.1A patent/EP2681230B1/en active Active
- 2012-03-05 BR BR112013022252-2A patent/BR112013022252B1/pt active IP Right Grant
- 2012-03-05 JP JP2013555900A patent/JP5967665B2/ja active Active
- 2012-03-06 AR ARP120100713A patent/AR085620A1/es active IP Right Grant
- 2012-03-06 AR ARP120100714A patent/AR088719A1/es active IP Right Grant
Non-Patent Citations (3)
| Title |
|---|
| A rapid method for purifying osteopontin from bovine milk and interaction between osteopontin and other milk proteins;Azuma N et al;《International Dairy Journal》;20060401;370-378 |
| Fractionation of bovine whey proteins and characterization by proteomic techniques;Bertram Y Fong et al;《International Dairy Journal》;20080131;23-46 |
| Purification and characterization of osteopontin from human milk;Sorensen S et al;《Protein Expression and Purification》;20030801;238-245 |
Also Published As
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| CN105085649B (zh) | 使用包含cmp或酪蛋白种类的给料分离骨桥蛋白的方法 | |
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