CN105079381A - Compound preparation of traditional Chinese Medicine decoction pieces for treating deficiency of kidney as well as preparation method and application of compound preparation - Google Patents
Compound preparation of traditional Chinese Medicine decoction pieces for treating deficiency of kidney as well as preparation method and application of compound preparation Download PDFInfo
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Abstract
The invention discloses a compound preparation of traditional Chinese Medicine decoction pieces for treating deficiency of kidney, wherein the preparation is a compound preparation of traditional Chinese Medicine decoction pieces, and the preparation consists of the following components in parts by mass: 20 parts of forged magnet, 80 parts of prepared cornus officinalis, 80 parts of yam and 60 parts of rhizoma alismatis. The invention also discloses a preparation method as well as application and packaging of the compound preparation. The preparation, as a pure traditional Chinese medicinal preparation, is prepared from natural ingredients through modern advanced pharmaceutical technology; the traditional Chinese medicinal preparation disclosed by the invention is safe and mild in ingredient, non-irritating and harmless to body health, and is capable of treating both symptoms and root causes; and the preparation disclosed by the invention is simple in preparation, good in absorption effect, significant in curative effect, free from side effect and high in safety, and the preparation is conducive to timely relieving symptoms of patients.
Description
Technical field
The present invention relates to compound Chinese medicine decoction pieces, more precisely a kind for the treatment of prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney and preparation method and application's packaging.
Background technology
Hiccough and deaf can be used as clinical common sympton, is common in the various diseases process of each section, also can become separately a kind of ear disease., all can there is Hiccough and deaf in the otology pathological changes (as otitis media, the perforation of ear drum) of doctor trained in Western medicine, many acute febrile infectious disease (as scarlet fever, influenza), intracranial lesion (as the cerebral tumor, acoustic neuroma), the disease such as drug intoxication and hypertension, beautiful You Shi disease, anemia, neurasthenia.
At present, clinical treatment tinnitus deaf disease generally adopts artificial cochlea, takes the composite treatment such as blood vessel dilating class Western medicine or Chinese medicine, acupuncture and external used medicine, but does not all reach best therapeutic effect.
Summary of the invention
Due to the above-mentioned shortcoming of prior art, the present invention proposes the prepared slices of Chinese crude drugs combination preparation that a kind for the treatment of is suffered from a deficiency of the kidney.
The present invention is by the following technical solutions:
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.
Also comprise the first compounding ingredients, described first compounding ingredients comprise that Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Cordyceps, Fructus Lycii, Herba Leonuri, Herba Cynomorii, Fructus Cnidii, clam are confused, still SIZI, Radix Aconiti Kusnezoffii, Fructus Rosae Laevigatae, Herba Epimedii, Herba Cistanches, Fructus Chaenomelis, Cornu Cervi.
The weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 5-18 part, Fructus Schisandrae Chinensis 5-18 part, Cordyceps 5-16 part, Fructus Lycii 5-18 part, Herba Leonuri 6-15 part, Herba Cynomorii 6-17 part, Fructus Cnidii 5-17 part, the confused 5-18 part of clam, still SIZI 5-18 part, Radix Aconiti Kusnezoffii 5-19 part, Fructus Rosae Laevigatae 5-19 part, Herba Epimedii 5-14 part, Herba Cistanches 6-25 part, Fructus Chaenomelis 5-19 part, Cornu Cervi 5-18 part.
Also comprise the second compounding ingredients, described second compounding ingredients comprises Radix Achyranthis Bidentatae, Cortex Acanthopancis, Radix Angelicae Sinensis, Radix Ginseng Rubra, Actinolitum, Cornu Cervi Degelatinatum, the Cortex Eucommiae, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Ginseng, Mahonia fortunei (Lindl.) Fedde, Fructus Cnidii, Cortex Albiziae.
Described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 5-18 part, Cortex Acanthopancis 15-24 part, Radix Angelicae Sinensis 8-18 part, Radix Ginseng Rubra 8-18 part, Actinolitum 5-18 part, Cornu Cervi Degelatinatum 5-19 part, Cortex Eucommiae 8-18 part, Radix Glycyrrhizae 6-18 part, Rhizoma Polygonati 5-18 part, Radix Ginseng 5-18 part, Mahonia fortunei (Lindl.) Fedde 5-18 part, Fructus Cnidii 5-18 part, Cortex Albiziae 5-18 part.
A preparation method for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, comprises the following steps: will forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and Rhizoma Alismatis and pulverize, and make coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-45 DEG C ~-40 DEG C, keep carrying out lyophilization in 2 hours; The system absolute pressure of being evacuated to is 20 ~ 80Pa, starts to be heated to 30 DEG C ~ 35 DEG C; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of pure powder is 0.5-2 μm.
Also comprise the steps, after being cleaned by the first compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-33 DEG C ~-32 DEG C, keep carrying out lyophilization in 1.8-3 hour; The system absolute pressure of being evacuated to is 80 ~ 90Pa, starts to be heated to 22 DEG C ~ 28 DEG C, sublimation drying 12 ~ 16 hours; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of the first compounding ingredients is 0.5-2 μm.
Further comprising the steps of, after being cleaned by the second compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-34 DEG C ~-28 DEG C, keep carrying out lyophilization in 1.5-2.5 hour; The system absolute pressure of being evacuated to is 20 ~ 48Pa, starts to be heated to 60 DEG C ~ 70 DEG C, sublimation drying 12 ~ 20 hours; Added by dried activity extract in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the second compounding ingredients is 0.5-2 μm.
An application packages for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, is packaged into bag in proportion by forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.
Also comprise adjuvant in described packaging, wherein forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and the total amount of Rhizoma Alismatis and the proportioning of adjuvant is 1: 1.
Described adjuvant is for comprising disintegrating agent, lubricant and filler.
Described disintegrating agent is one or more in carboxymethyl starch sodium, hyprolose, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose; The consumption of described disintegrating agent is the 2-5% of described active constituents of medicine; Described lubricant is one or more in colloidal silica, sodium stearyl fumarate, Pulvis Talci and magnesium stearate; The consumption of described lubricant is the 3-9% of described active constituents of medicine; Described filler is one or more in lactose, Lactis Anhydrous, mannitol, microcrystalline Cellulose, starch, xylitol, pregelatinized Starch and maltose alcohol; The consumption of described filler be the 2-5 of described active constituents of medicine weight doubly.The application of prepared slices of Chinese crude drugs combination preparation in the deaf medicine of preparation treatment that a kind for the treatment of is suffered from a deficiency of the kidney
The present invention has the following advantages: the present invention takes from natural component, for pure Chinese medicinal preparation, and adopt modern advanced medical pharmaceutical technology to be prepared from, Chinese medicine preparation composition safety of the present invention is gentle, non-stimulated without harm to health, can play the effect for the treatment of both the principal and secondary aspects of a disease for treatment, the present invention prepares simply, good absorbing effect, evident in efficacy, have no side effect, safety is high, is conducive to sufferer and alleviates condition of illness in time.This technology have passed the top expert testimony of Chinese herbal medicine industry, and former basis of grinding medicine has breakthrough use value.
Detailed description of the invention:
Below in conjunction with detailed description of the invention, describe the present invention in detail.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.In addition should be understood that those skilled in the art can make various changes or modifications the present invention, and these equivalent form of values fall within the application's appended claims limited range equally after the content of having read the present invention's instruction.
Embodiment 1
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.
Embodiment 2
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150
:15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 5 parts, Fructus Schisandrae Chinensis 5 parts, Cordyceps 5 parts, Fructus Lycii 5 parts, Herba Leonuri 6 parts, Herba Cynomorii 6 parts, Fructus Cnidii 5 parts, confused 5 parts of clam, still SIZI 5 parts, Radix Aconiti Kusnezoffii 5 parts, Fructus Rosae Laevigatae 5 parts, Herba Epimedii 5 parts, Herba Cistanches 6 parts, Fructus Chaenomelis 5 parts, 5 parts, Cornu Cervi.
Embodiment 3
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 18 parts, Fructus Schisandrae Chinensis 18 parts, Cordyceps 16 parts, Fructus Lycii 18 parts, Herba Leonuri 15 parts, Herba Cynomorii 17 parts, Fructus Cnidii 17 parts, confused 18 parts of clam, still SIZI 18 parts, Radix Aconiti Kusnezoffii 19 parts, Fructus Rosae Laevigatae 19 parts, Herba Epimedii 14 parts, Herba Cistanches 25 parts, Fructus Chaenomelis 19 parts, 18 parts, Cornu Cervi.
Embodiment 4
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150
:15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 12 parts, Fructus Schisandrae Chinensis 11 parts, Cordyceps 10 parts, Fructus Lycii 12 parts, Herba Leonuri 11 parts, Herba Cynomorii 12 parts, Fructus Cnidii 10 parts, confused 10 parts of clam, still SIZI 10 parts, Radix Aconiti Kusnezoffii 11 parts, Fructus Rosae Laevigatae 13 parts, Herba Epimedii 8 parts, Herba Cistanches 17 parts, Fructus Chaenomelis 11 parts, 12 parts, Cornu Cervi.
Embodiment 5
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the second compounding ingredients, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 5 parts, Cortex Acanthopancis 15 parts, Radix Angelicae Sinensis 8 parts, Radix Ginseng Rubra 8 parts, Actinolitum 5 parts, Cornu Cervi Degelatinatum 5 parts, the Cortex Eucommiae 8 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Polygonati 5 parts, Radix Ginseng 5 parts, Mahonia fortunei (Lindl.) Fedde 5 parts, Fructus Cnidii 8 parts, Cortex Albiziae 5 parts.
Embodiment 6
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the second compounding ingredients, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 18 parts, Cortex Acanthopancis 24 parts, Radix Angelicae Sinensis 18 parts, Radix Ginseng Rubra 18 parts, Actinolitum 18 parts, Cornu Cervi Degelatinatum 19 parts, the Cortex Eucommiae 18 parts, 18 parts, Radix Glycyrrhizae, Rhizoma Polygonati 18 parts, Radix Ginseng 18 parts, Mahonia fortunei (Lindl.) Fedde 18 parts, Fructus Cnidii 18 parts, Cortex Albiziae 18 parts.
Embodiment 7
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the second compounding ingredients, described second compounding ingredients be 150 with the mass ratio of described Radix Codonopsis
:12, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 11 parts, Cortex Acanthopancis 19 parts, Radix Angelicae Sinensis 13 parts, Radix Ginseng Rubra 14 parts, Actinolitum 10 parts, Cornu Cervi Degelatinatum 11 parts, the Cortex Eucommiae 12 parts, 11 parts, Radix Glycyrrhizae, Rhizoma Polygonati 10 parts, Radix Ginseng 12 parts, Mahonia fortunei (Lindl.) Fedde 9 parts, Fructus Cnidii 8 parts, Cortex Albiziae 9 parts.
Embodiment 8
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 5 parts, Fructus Schisandrae Chinensis 5 parts, Cordyceps 5 parts, Fructus Lycii 5 parts, Herba Leonuri 6 parts, Herba Cynomorii 6 parts, Fructus Cnidii 5 parts, confused 5 parts of clam, still SIZI 5 parts, Radix Aconiti Kusnezoffii 5 parts, Fructus Rosae Laevigatae 5 parts, Herba Epimedii 5 parts, Herba Cistanches 6 parts, Fructus Chaenomelis 5 parts, 5 parts, Cornu Cervi.Also comprise the second compounding ingredients, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 5 parts, Cortex Acanthopancis 15 parts, Radix Angelicae Sinensis 8 parts, Radix Ginseng Rubra 8 parts, Actinolitum 5 parts, Cornu Cervi Degelatinatum 5 parts, the Cortex Eucommiae 8 parts, 6 parts, Radix Glycyrrhizae, Rhizoma Polygonati 5 parts, Radix Ginseng 5 parts, Mahonia fortunei (Lindl.) Fedde 5 parts, Fructus Cnidii 8 parts, Cortex Albiziae 5 parts.
Embodiment 9
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 18 parts, Fructus Schisandrae Chinensis 18 parts, Cordyceps 16 parts, Fructus Lycii 18 parts, Herba Leonuri 15 parts, Herba Cynomorii 17 parts, Fructus Cnidii 17 parts, confused 18 parts of clam, still SIZI 18 parts, Radix Aconiti Kusnezoffii 19 parts, Fructus Rosae Laevigatae 19 parts, Herba Epimedii 14 parts, Herba Cistanches 25 parts, Fructus Chaenomelis 19 parts, 18 parts, Cornu Cervi.Also comprise the second compounding ingredients, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 18 parts, Cortex Acanthopancis 24 parts, Radix Angelicae Sinensis 18 parts, Radix Ginseng Rubra 18 parts, Actinolitum 18 parts, Cornu Cervi Degelatinatum 19 parts, the Cortex Eucommiae 18 parts, 18 parts, Radix Glycyrrhizae, Rhizoma Polygonati 18 parts, Radix Ginseng 18 parts, Mahonia fortunei (Lindl.) Fedde 18 parts, Fructus Cnidii 18 parts, Cortex Albiziae 18 parts.
Embodiment 10
The prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, said preparation is herbal mixture decoction pieces preparation, comprises each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise the first compounding ingredients, and the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 12 parts, Fructus Schisandrae Chinensis 11 parts, Cordyceps 10 parts, Fructus Lycii 12 parts, Herba Leonuri 11 parts, Herba Cynomorii 12 parts, Fructus Cnidii 10 parts, confused 10 parts of clam, still SIZI 10 parts, Radix Aconiti Kusnezoffii 11 parts, Fructus Rosae Laevigatae 13 parts, Herba Epimedii 8 parts, Herba Cistanches 17 parts, Fructus Chaenomelis 11 parts, 12 parts, Cornu Cervi.Also comprise the second compounding ingredients, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 11 parts, Cortex Acanthopancis 19 parts, Radix Angelicae Sinensis 13 parts, Radix Ginseng Rubra 14 parts, Actinolitum 10 parts, Cornu Cervi Degelatinatum 11 parts, the Cortex Eucommiae 12 parts, 11 parts, Radix Glycyrrhizae, Rhizoma Polygonati 10 parts, Radix Ginseng 12 parts, Mahonia fortunei (Lindl.) Fedde 9 parts, Fructus Cnidii 8 parts, Cortex Albiziae 9 parts.
Embodiment 11
A preparation method for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, comprises the following steps: will forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and Rhizoma Alismatis and pulverize, and make coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-45 DEG C ~-40 DEG C, keep carrying out lyophilization in 2 hours; The system absolute pressure of being evacuated to is 20 ~ 80Pa, starts to be heated to 30 DEG C ~ 35 DEG C; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of pure powder is 0.5-2 μm.
Also comprise the steps, after being cleaned by the first compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-33 DEG C ~-32 DEG C, keep carrying out lyophilization in 1.8-3 hour; The system absolute pressure of being evacuated to is 80 ~ 90Pa, starts to be heated to 22 DEG C ~ 28 DEG C, sublimation drying 12 ~ 16 hours; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of the first compounding ingredients is 0.5-2 μm.
Further comprising the steps of: after being cleaned by the second compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-34 DEG C ~-28 DEG C, keep carrying out lyophilization in 1.5-2.5 hour; The system absolute pressure of being evacuated to is 20 ~ 48Pa, starts to be heated to 60 DEG C ~ 70 DEG C, sublimation drying 12 ~ 20 hours; Added by dried activity extract in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the second compounding ingredients is 0.5-2 μm.
Embodiment 12
An application packages for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, is packaged into bag in proportion by forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.
Embodiment 13
An application packages for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, is packaged into bag in proportion by forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise adjuvant in described packaging, wherein forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and the total amount of Rhizoma Alismatis and the proportioning of adjuvant is 1: 1.Described adjuvant is for comprising disintegrating agent, lubricant and filler.Described disintegrating agent is one or more in carboxymethyl starch sodium, hyprolose, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose; The consumption of described disintegrating agent is 2% of described active constituents of medicine; Described lubricant is one or more in colloidal silica, sodium stearyl fumarate, Pulvis Talci and magnesium stearate; The consumption of described lubricant is 3% of described active constituents of medicine; Described filler is one or more in lactose, Lactis Anhydrous, mannitol, microcrystalline Cellulose, starch, xylitol, pregelatinized Starch and maltose alcohol; The consumption of described filler is 2 times of described active constituents of medicine weight.
Embodiment 13
An application packages for the prepared slices of Chinese crude drugs combination preparation that treatment is suffered from a deficiency of the kidney, is packaged into bag in proportion by forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.Also comprise adjuvant in described packaging, wherein forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and the total amount of Rhizoma Alismatis and the proportioning of adjuvant is 1: 1.Described adjuvant is for comprising disintegrating agent, lubricant and filler.Described disintegrating agent is one or more in carboxymethyl starch sodium, hyprolose, crospolyvinylpyrrolidone and cross-linking sodium carboxymethyl cellulose; The consumption of described disintegrating agent is 5% of described active constituents of medicine; Described lubricant is one or more in colloidal silica, sodium stearyl fumarate, Pulvis Talci and magnesium stearate; The consumption of described lubricant is 9% of described active constituents of medicine; Described filler is one or more in lactose, Lactis Anhydrous, mannitol, microcrystalline Cellulose, starch, xylitol, pregelatinized Starch and maltose alcohol; The consumption of described filler is 5 times of described active constituents of medicine weight.
Embodiment 14
Clinical observation treatment is carried out to 194 routine Hiccough and deaf persons, wherein man 106 example, female 88 example, 17 ~ 79 years old age.
(2) Therapeutic Method
Warm water takes orally, three times on the one, infusion batroxobin 10Bu first, the next day to 5Bu, being used in conjunction is for 3 times a course for the treatment of, and simultaneously Combined with Oral takes the preparation of embodiment 1, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 month, and severe case serve on 3 months and can fully recover.
(3) curative effect determinate standard
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.
(4) clinical effectiveness
Clinical cure 123 example (63%), effective 11 examples (5.6%), effective 7 examples (3.6%).
Embodiment 15
Clinical observation treatment is carried out to 194 routine Hiccough and deaf persons, wherein man 106 example, female 88 example, 17 ~ 79 years old age.
(2) Therapeutic Method
Warm water takes orally, three times on the one, infusion batroxobin 10Bu first, the next day to 5Bu, being used in conjunction is for 3 times a course for the treatment of, and simultaneously Combined with Oral takes the preparation of embodiment 4, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 month, and severe case serve on 3 months and can fully recover.
(3) curative effect determinate standard
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.
(4) clinical effectiveness
Clinical cure 134 example (69%), effective 15 examples (10.82%), effective 9 examples (6.70%), invalid 3 examples (1.55%), total effective rate is 98.45%.
Embodiment 16
Clinical observation treatment is carried out to 194 routine Hiccough and deaf persons, wherein man 106 example, female 88 example, 17 ~ 79 years old age.
(2) Therapeutic Method
Warm water takes orally, three times on the one, infusion batroxobin 10Bu first, the next day to 5Bu, being used in conjunction is for 3 times a course for the treatment of, and simultaneously Combined with Oral takes the preparation of embodiment 7, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 month, and severe case serve on 3 months and can fully recover.
(3) curative effect determinate standard
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.
(4) clinical effectiveness
Clinical cure 135 example (70%), effective 16 examples (8%), effective 10 examples (5.1%), invalid 3 examples (1.55%), total effective rate is 98.45%.
Embodiment 17
Clinical observation treatment is carried out to 194 routine Hiccough and deaf persons, wherein man 106 example, female 88 example, 17 ~ 79 years old age.
(2) Therapeutic Method
Warm water takes orally, three times on the one, infusion batroxobin 10Bu first, the next day to 5Bu, being used in conjunction is for 3 times a course for the treatment of, and simultaneously Combined with Oral takes the preparation of embodiment 10, each 2 ~ 5g, one after each meal.Calculate treatment time according to conditions of patients weight, patients with mild takes about 1 month, and severe case serve on 3 months and can fully recover.
(3) curative effect determinate standard
Cure: symptom all disappears; Main Physico-chemical tests index is normally.
Effective: symptomatology is eliminated or cardinal symptom is eliminated; Physico-chemical tests index is normal.
Effective: cardinal symptom disappears substantially; Main Physico-chemical tests index makes moderate progress.
Invalid: main Physico-chemical tests index is front unchanged with treatment.
(4) clinical effectiveness
Clinical cure 157 example (80.93%), effective 21 examples (10.82%), effective 13 examples (6.70%), invalid 3 examples (1.55%), total effective rate is 98.45%.
First composite drug has the kidney invigorating, drying damp and strengthening spleen effect, and the second composite drug has effect of tonifying liver, therefore the first compounding ingredients and the second compounding ingredients have collaborative effect relative to each component in embodiment 1, strengthening has been used to it, and total effective rate is apparently higher than curative effect during alone first compounding ingredients.First compounding ingredients of the present invention and the second compounding ingredients monarch reasonably combined, based on invigorating the liver and kidney, hold concurrently solid to the heart, liver, spleen, lung, by the conditioning to human body integral function, thus reach and fundamentally cure Hiccough and deaf, rocky effect.
Embodiment 18
Routine with Drug therapy Patients with Kidney Deficiency Type 54 of the present invention through 4 years, wherein man 36 example, female 18 example.
| Group | Improve | Part is improved | Without improving | Effective percentage |
| Matched group 1 | 3 | 37 | 14 | 74 |
| Matched group 2 | 6 | 39 | 9 | 83 |
| Matched group 3 | 6 | 37 | 11 | 79 |
| Matched group 4 | 9 | 41 | 4 | 93 |
From the above, the present invention or a kind of good effect, instant effect, have no side effect, the Chinese medicine composition for the treatment of sudden deafness that cost is low.
Claims (9)
1. a treatment prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, is characterized in that, comprise each component that mass parts is following, forging Magnetitum 20 parts, Fructus Corni (processed) 80 parts, Rhizoma Dioscoreae 80 parts and Rhizoma Alismatis 60 parts.
2. the treatment according to claim 1 prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, it is characterized in that, also comprise the first compounding ingredients, described first compounding ingredients comprise that Radix Rehmanniae Preparata, Fructus Schisandrae Chinensis, Cordyceps, Fructus Lycii, Herba Leonuri, Herba Cynomorii, Fructus Cnidii, clam are confused, still SIZI, Radix Aconiti Kusnezoffii, Fructus Rosae Laevigatae, Herba Epimedii, Herba Cistanches, Fructus Chaenomelis, Cornu Cervi.
3. the treatment according to claim 1 prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, it is characterized in that, the weight ratio of described first compounding ingredients and Fructus Corni (processed) is 150: 15, and in described first compounding ingredients, the mass fraction of each component is Radix Rehmanniae Preparata 5-18 part, Fructus Schisandrae Chinensis 5-18 part, Cordyceps 5-16 part, Fructus Lycii 5-18 part, Herba Leonuri 6-15 part, Herba Cynomorii 6-17 part, Fructus Cnidii 5-17 part, the confused 5-18 part of clam, still SIZI 5-18 part, Radix Aconiti Kusnezoffii 5-19 part, Fructus Rosae Laevigatae 5-19 part, Herba Epimedii 5-14 part, Herba Cistanches 6-25 part, Fructus Chaenomelis 5-19 part, Cornu Cervi 5-18 part.
4. the treatment according to claim 1 and 2 prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, it is characterized in that, also comprise the second compounding ingredients, described second compounding ingredients comprises Radix Achyranthis Bidentatae, Cortex Acanthopancis, Radix Angelicae Sinensis, Radix Ginseng Rubra, Actinolitum, Cornu Cervi Degelatinatum, the Cortex Eucommiae, Radix Glycyrrhizae, Rhizoma Polygonati, Radix Ginseng, Mahonia fortunei (Lindl.) Fedde, Fructus Cnidii, Cortex Albiziae.
5. the treatment according to claim 3 prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, it is characterized in that, described second compounding ingredients be 150: 12 with the mass ratio of described Radix Codonopsis, and in described second compounding ingredients, the mass fraction of each component is Radix Achyranthis Bidentatae 5-18 part, Cortex Acanthopancis 15-24 part, Radix Angelicae Sinensis 8-18 part, Radix Ginseng Rubra 8-18 part, Actinolitum 5-18 part, Cornu Cervi Degelatinatum 5-19 part, Cortex Eucommiae 8-18 part, Radix Glycyrrhizae 6-18 part, Rhizoma Polygonati 5-18 part, Radix Ginseng 5-18 part, Mahonia fortunei (Lindl.) Fedde 5-18 part, Fructus Cnidii 5-18 part, Cortex Albiziae 5-18 part.
6. the treatment preparation method of prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, is characterized in that, comprise the following steps: will forge Magnetitum, Fructus Corni (processed), Rhizoma Dioscoreae and Rhizoma Alismatis and pulverize, and make coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-45 DEG C ~-40 DEG C, keep carrying out lyophilization in 2 hours; The system absolute pressure of being evacuated to is 20 ~ 80Pa, starts to be heated to 30 DEG C ~ 35 DEG C; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of pure powder is 0.5-2 μm.
7. the treatment according to claim 6 preparation method of prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, is characterized in that, also comprise the steps, after being cleaned by the first compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-33 DEG C ~-32 DEG C, keep carrying out lyophilization in 1.8-3 hour; The system absolute pressure of being evacuated to is 80 ~ 90Pa, starts to be heated to 22 DEG C ~ 28 DEG C, sublimation drying 12 ~ 16 hours; Added by dried coarse powder in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the pure powder of the first compounding ingredients is 0.5-2 μm.
8. the treatment according to claim 7 preparation method of prepared slices of Chinese crude drugs combination preparation of suffering from a deficiency of the kidney, is characterized in that, further comprising the steps of, and after being cleaned by the second compounding ingredients, cutting, big gun process process, pulverizing, makes coarse powder, then carry out sterilization treatment; After coarse powder is put into freeze drying box, start freeze dryer, after freeze drying box temperature is down to-34 DEG C ~-28 DEG C, keep carrying out lyophilization in 1.5-2.5 hour; The system absolute pressure of being evacuated to is 20 ~ 48Pa, starts to be heated to 60 DEG C ~ 70 DEG C, sublimation drying 12 ~ 20 hours; Added by dried activity extract in ultrafine crusher and carry out beating powder, after beating powder, the particle diameter of the second compounding ingredients is 0.5-2 μm.
9. the application of prepared slices of Chinese crude drugs combination preparation in the deaf medicine of preparation treatment of suffering from a deficiency of the kidney as the treatment in claim 1 to 5 as described in any one.
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| CN104435051A (en) * | 2014-10-14 | 2015-03-25 | 董颖 | Calculus bovis Chinese medicine decoction piece combined preparation and preparation method and application package |
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