CN103007063B - Medicinal composition for treating facial paralysis and preparation method thereof - Google Patents
Medicinal composition for treating facial paralysis and preparation method thereof Download PDFInfo
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- CN103007063B CN103007063B CN201210576452.5A CN201210576452A CN103007063B CN 103007063 B CN103007063 B CN 103007063B CN 201210576452 A CN201210576452 A CN 201210576452A CN 103007063 B CN103007063 B CN 103007063B
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Abstract
The invention provides a medicinal composition for treating facial paralysis, which consists of astragalus, cassia twig, divaricate saposhnikovia root, angelica root, hemlock parsley, red peony root, medicinal cyathula root, ginger processed pinellia tuber, loofah sponge, gastrodia elata, pseudo-ginseng, earthworm, centipede, stiff silkworm, suberect spatholobus stem and indigowoad leaf. The medicinal composition can be added with conventional auxiliary materials according to a conventional process to prepare a clinically acceptable preparation, has a remarkable effect in treating facial paralysis, and does not have side effect.
Description
Technical field
The invention belongs to field of medicaments, relate to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition of facial paralysis.
Background technology
Facial paralysis is common clinical, belongs to the sick categories such as Chinese medicine " wapperijaw bar ", " wapperijaw ", " facial paralysis ".The traditional Chinese medical science thinks, primary disease is many by venation inanition, wind and cold invasion and attack, so that stagnant through vapour lock, and disharmony between QI and blood, the stagnant passages through which vital energy circulates of the stasis of blood, and it is foster to cause meridians to lose in moistening, muscle is vertical slowly not to be received, thereby causes all symptoms.
Facial paralysis cardinal symptom is a unexpected side face muscle paralysis, and eyelid can not be closed, sheds tears, facial expression action disappears, and the asophia of speaking, is leaked at the hourglass meal of having a meal, volume stricture of vagina disappears, and can not do to frown, wrinkle volume, the drum cheek, show tooth and the action such as whistle, and nasolabial fold shoals.When patient closes one's eyes, Ipsilateral eyeball turns to outer top, often exposes white sclera.
At present, the medicine of this disease of western medical treatment is divided three classes substantially clinically: antiviral agents, glucocorticoid, Neurotrophic drugs etc.Because the pathogenesis of facial paralysis itself is not yet completely clear, these drug targets are unclear, act on limitedly, and curative effect is single, and effective percentage is low, more after easily recurrence, some drugs side effect is outstanding.
On tcm clinical practice, take the dialectical Therapeutic Method treating more, conventional have various plus-minus facial paralysis prescriptions, capsule, facial paralysis external application of ointment or with other prescriptions add and subtract, acupuncture and moxibustion therapy, these methods exist the length course for the treatment of, shortcoming slow, DeGrain takes effect, acupuncture and moxibustion therapy had certain restriction and has the shortcomings such as certain misery treatment place, time, difficult by acceptance that patient approves.
Summary of the invention
Pharmaceutical composition providing a kind of facial paralysis and preparation method thereof is provided the object of the invention.
Another object of the present invention is to provide the new purposes of this pharmaceutical composition.
The present invention is achieved through the following technical solutions:
The crude drug of pharmaceutical composition of the present invention consists of:
Radix Astragali 15-50 weight portion, Ramulus Cinnamomi 4-12 weight portion, Radix Saposhnikoviae 4-10 weight portion, Radix Angelicae Dahuricae 8-15 weight portion, Rhizoma Chuanxiong 6-12 weight portion, Radix Paeoniae Rubra 12-18 weight portion, Radix Cyathulae 8-15 weight portion, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 4-10 weight portion, Retinervus Luffae Fructus 8-15 weight portion, Rhizoma Gastrodiae 3-9 weight portion, Radix Notoginseng 3-9 weight portion, Pheretima 10-15 weight portion, Scolopendra 3-9 weight portion, Bombyx Batryticatus 4-12 weight portion, Caulis Spatholobi 15-25 weight portion, Folium Isatidis 8-20 weight portion.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Astragali 30 weight portions, Ramulus Cinnamomi 6 weight portions, Radix Saposhnikoviae 6 weight portions, the Radix Angelicae Dahuricae 10 weight portions, Rhizoma Chuanxiong 10 weight portions, Radix Paeoniae Rubra 15 weight portions, Radix Cyathulae 10 weight portions, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6 weight portions, Retinervus Luffae Fructus 10 weight portions, Rhizoma Gastrodiae 6 weight portions, Radix Notoginseng 6 weight portions, Pheretima 12 weight portions, Scolopendra 6 weight portions, Bombyx Batryticatus 6 weight portions, Caulis Spatholobi 20 weight portions, Folium Isatidis 12 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Astragali 20 weight portions, Ramulus Cinnamomi 8 weight portions, Radix Saposhnikoviae 9 weight portions, the Radix Angelicae Dahuricae 10 weight portions, Rhizoma Chuanxiong 7 weight portions, Radix Paeoniae Rubra 15 weight portions, Radix Cyathulae 12 weight portions, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7 weight portions, Retinervus Luffae Fructus 8 weight portions, Rhizoma Gastrodiae 5 weight portions, Radix Notoginseng 9 weight portions, Pheretima 13 weight portions, Scolopendra 4 weight portions, Bombyx Batryticatus 8 weight portions, Caulis Spatholobi 24 weight portions, Folium Isatidis 13 weight portions.
The crude drug composition of pharmaceutical composition of the present invention is preferably:
The Radix Astragali 45 weight portions, Ramulus Cinnamomi 5 weight portions, Radix Saposhnikoviae 7 weight portions, the Radix Angelicae Dahuricae 14 weight portions, Rhizoma Chuanxiong 7 weight portions, Radix Paeoniae Rubra 16 weight portions, Radix Cyathulae 11 weight portions, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5 weight portions, Retinervus Luffae Fructus 10 weight portions, Rhizoma Gastrodiae 8 weight portions, Radix Notoginseng 4 weight portions, Pheretima 11 weight portions, Scolopendra 8 weight portions, Bombyx Batryticatus 5 weight portions, Caulis Spatholobi 18 weight portions, Folium Isatidis 18 weight portions.
Weigh each taste crude drug by pharmaceutical composition crude drug composition of the present invention, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 2.5-3.5 hour of 13-17 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
Preferably, weigh each taste crude drug by pharmaceutical composition crude drug composition of the present invention, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 15 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
Pharmaceutical composition crude drug of the present invention adds conventional adjuvant, according to common process, makes slow releasing preparation, quick releasing formulation or controlled release preparation.
The property of medicine and the pharmacology of the selected Chinese herbal medicine of the present invention are respectively:
The Radix Astragali: sweet, tepor.Invigorating the spleen and replenishing QI, hidroschesis, inducing diuresis to remove edema, except taking poison and growing muscle due.
Ramulus Cinnamomi: pungent, sweet.Temperature.Relieving the exterior syndrome by diaphoresis, antalgic, supporing yang activating QI.
Radix Saposhnikoviae: pungent, sweet, tepor.Expelling pathogenic wind from the body surface, removing dampness to relieve pain, relieving convulsion.
The Radix Angelicae Dahuricae: pungent, warm in nature.Dispel the wind, dampness, detumescence, pain relieving.
Rhizoma Gastrodiae: sweet, flat.Endogenous wind stopping relieving convulsion, suppressing liver-YANG, dispelling wind and removing obstruction in the collateral.
Rhizoma Chuanxiong: pungent, warm, fragrant dry.Blood-activating and qi-promoting, wind-expelling pain-stopping, dissipating depression of QI dampness.
Radix Paeoniae Rubra: bitter, be slightly cold.Clots absorbing, pain relieving, removing heat from blood, detumescence.
Radix Notoginseng: sweet, micro-hardship, tepor.Hemostasis dissipating blood stasis, subduing swelling and relieving pain.
Radix Cyathulae: sweet, micro-hardship, flat.Promoting blood circulation to restore menstrual flow, expelling wind and removing dampness, inducing diuresis for treating stranguria syndrome.
Pheretima: become, tremble with fear.Heat clearing away suppressing the hyperactive liver, relieving spasm by subduing liver-wind, relieving asthma, diuresis, dredging collateral eliminating impediment.
Scolopendra: pungent, temperature.Endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain.
Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): pungent, warm.Warming middle-JIAO reduces phlegm, stopping nausea and vomiting by lowering the adverse flow of QI.
Caulis Spatholobi: bitter, sweet, temperature.Enrich blood, invigorate blood circulation, dredging collateral.
Retinervus Luffae Fructus: sweet, cool.Dredging collateral, invigorates blood circulation, and dispels the wind.
Bombyx Batryticatus: pungent, one-tenth, tepor.Expelling wind to relieve convulsion, dissipating phlegm and resolving masses.
Folium Isatidis: bitter, Great Cold.Heat-clearing and toxic substances removing, blood cooling and ecchymoses removing.
In conjunction with pharmacology and the property of medicine of above-mentioned raw materials medicine, through a large amount of research and the research of clinical treatment repeatedly, develop pharmaceutical composition of the present invention, medicine composite for curing facial paralysis effect of the present invention significantly and have no side effect, has dispelling cold by warming the meridian, eleminating phlegm and freeing channels, promoting blood circulation by removing wind, benefiting QI and nourishing blood effect.Pharmaceutical composition of the present invention can reach the effect to facial paralysis treating both the principal and secondary aspects of a disease, eliminates clinical symptoms, finally reaches healing object.
Experiment and the specific embodiment are used for further illustrating but are not limited to the present invention below.
experimental example
Experimental example 1
Pharmaceutical composition of the present invention in the routine facial paralysis patient of clinical treatment 68, wherein male 41 examples, female's 27 examples, the course of disease is the shortest 2 weeks, the longest 2 years.
Efficacy determination: " the disease of tcm Standardization of diagnosis and curative effect " promulgated for 1994 according to State Administration of Traditional Chinese Medicine, adopts 3 grade standards.
Recovery from illness: close one's eyes, volume stricture of vagina and both sides nasolabial fold symmetry, the drum cheek is accessible grinningly.
Effective: volume stricture of vagina and both sides nasolabial fold almost symmetry, close one's eyes and slight obstacle grinningly.
Invalid: volume stricture of vagina and both sides nasolabial fold are obviously asymmetric, close one's eyes and serious hindrance grinningly.
Therapeutic outcome sees the following form:
Above-mentioned clinical research shows: pharmaceutical composition of the present invention in the routine facial paralysis patient of clinical treatment 68, after treatment 4 weeks, recovery from illness have 61 examples, effectively have 4 examples, invalid have 3 examples, effective percentage reaches 95.6%.
Embodiment 1-embodiment 9 all can realize the effect of experimental example 1.
Experimental example 2
Case: Zhang, female, 42 years old, burst right side ptosis of labial angle 1 day.
Have a medical check-up: eyelid can not be closed, facial expression action disappears, and right side volume stricture of vagina disappears, and right side nasolabial fold shoals.
Diagnosis: because of tired, suffering from cold causes facial paralysis.
Treatment: take acyclovir 0.2tid, prednisone 10mg qd, mecobalamin 500ug bid, treats 4 days, symptom is improved not obvious, takes pharmaceutical composition every day 2 times of the embodiment of the present invention 1, the 3rd day, symptom is improved obviously, serve on 1 week, and facial paralysis disease disappears substantially.Consolidate again and take recovery from illness after 1 week.
Experimental example 3
Case: Lee so-and-so, female, 21 years old, students, because of tired and in the bus sleep of blowing a cold wind over, played rear a discoverys dysraphism, distortion of commissure, facial numbness morning next day.Diagnosis facial paralysis, takes mecobalamin 500ug bid treatment 4 days, and symptom is improved not obvious, takes pharmaceutical composition every day 2 times of the embodiment of the present invention 2, and the 5th day, symptom was improved obviously, fully recovers after serveing on 2 weeks.
Experimental example 4
Case grandson, man, 43 years old, suffer from cold because of after having a bath, play aftersensation facial numbness morning next day, find distortion of commissure, can not rouse the cheek.Diagnosis facial paralysis, pharmaceutical composition every day 2 times of taking the embodiment of the present invention 3, the 7th day, symptom was improved obviously, fully recovered after serveing on 3 weeks.
Experimental example 5
Case Lee, man, 72 years old, because windowing night, sleep was suffered from cold, play aftersensation facial numbness morning next day, find that distortion of commissure, drinking-water time leak, diagnosis facial paralysis, pharmaceutical composition every day 2 times of taking the embodiment of the present invention 4, the 10th day, symptom was improved obviously, serve on rear recovery from illness in 3 weeks.
Experimental example 6
Case Korea Spro, female, 70 years old, because suffering from cold after fatigue, plays rear discovery distortion of commissure, facial numbness morning next day.Diagnosis facial paralysis, pharmaceutical composition every day 2 times of taking the embodiment of the present invention 5, the 8th day, symptom was improved obviously, fully recovered after serveing on 4 weeks.
Experimental example 7
Case Wang, female, 76 years old, after suffering from cold, plays rear discovery distortion of commissure, the disappearance of volume stricture of vagina, facial numbness morning next day.Diagnosis facial paralysis, pharmaceutical composition every day 2 times of taking the embodiment of the present invention 6, after 1 week, symptom is improved, and fully recovers after serveing on 5 weeks.
The specific embodiment
Embodiment 1
Radix Astragali 30g, Ramulus Cinnamomi 12g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 6g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 2.5 hours of 13 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make oral liquid.
Embodiment 2
Radix Astragali 50g, Ramulus Cinnamomi 12g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 6g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 14 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make pill.
Embodiment 3
Radix Astragali 30g, Ramulus Cinnamomi 12g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 15g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 15g, Rhizoma Gastrodiae 9g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 16 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make powder.
Embodiment 4
Radix Astragali 30g, Ramulus Cinnamomi 6g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 9g, Radix Notoginseng 6g, Pheretima 15g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3.5 hours of 17 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, granulation agent.
Embodiment 5
Radix Astragali 30g, Ramulus Cinnamomi 6g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 6g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 9g, Bombyx Batryticatus 12g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 15 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make capsule.
Embodiment 6
Radix Astragali 30g, Ramulus Cinnamomi 6g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 15g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 6g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 20g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 14 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make unguentum.
Embodiment 7
Radix Astragali 30g, Ramulus Cinnamomi 6g, Radix Saposhnikoviae 6g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 10g, Radix Paeoniae Rubra 15g, Radix Cyathulae 10g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 6g, Radix Notoginseng 6g, Pheretima 12g, Scolopendra 6g, Bombyx Batryticatus 6g, Caulis Spatholobi 20g, Folium Isatidis 12g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3.5 hours of 16 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make oral liquid.
Embodiment 8
Radix Astragali 20g, Ramulus Cinnamomi 8g, Radix Saposhnikoviae 9g, Radix Angelicae Dahuricae 10g, Rhizoma Chuanxiong 7g, Radix Paeoniae Rubra 15g, Radix Cyathulae 12g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 7g, Retinervus Luffae Fructus 8g, Rhizoma Gastrodiae 5g, Radix Notoginseng 9g, Pheretima 13g, Scolopendra 4g, Bombyx Batryticatus 8g, Caulis Spatholobi 24g, Folium Isatidis 13g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 13 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet.
Embodiment 9
Radix Astragali 45g, Ramulus Cinnamomi 5g, Radix Saposhnikoviae 7g, Radix Angelicae Dahuricae 14g, Rhizoma Chuanxiong 7g, Radix Paeoniae Rubra 16g, Radix Cyathulae 11g, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 5g, Retinervus Luffae Fructus 10g, Rhizoma Gastrodiae 8g, Radix Notoginseng 4g, Pheretima 11g, Scolopendra 8g, Bombyx Batryticatus 5g, Caulis Spatholobi 18g, Folium Isatidis 18g.
Weigh each taste crude drug by aforementioned pharmaceutical compositions crude drug composition, first the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus are added to the decocting 3 hours of 15 times of weight, filter centrifugal removing slag, be condensed into clear paste, again Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus are dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make controlled release preparation.
Claims (7)
1. a pharmaceutical composition for facial paralysis, is characterized in that this pharmaceutical composition crude drug consists of:
The Radix Astragali 30 weight portions, Ramulus Cinnamomi 6 weight portions, Radix Saposhnikoviae 6 weight portions, the Radix Angelicae Dahuricae 10 weight portions, Rhizoma Chuanxiong 10 weight portions, Radix Paeoniae Rubra 15 weight portions, Radix Cyathulae 10 weight portions, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 6 weight portions, Retinervus Luffae Fructus 10 weight portions, Rhizoma Gastrodiae 6 weight portions, Radix Notoginseng 6 weight portions, Pheretima 12 weight portions, Scolopendra 6 weight portions, Bombyx Batryticatus 6 weight portions, Caulis Spatholobi 20 weight portions, Folium Isatidis 12 weight portions.
2. pharmaceutical composition as claimed in claim 1, it is characterized in that weighing each taste crude drug by described pharmaceutical composition crude drug composition, first by the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus adds the decocting 2.5-3.5 hour of 13-17 times of weight, filter centrifugal removing slag, be condensed into clear paste, again by Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus is dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
3. pharmaceutical composition as claimed in claim 2, it is characterized in that weighing each taste crude drug by described pharmaceutical composition crude drug composition, first by the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus adds the decocting 3 hours of 15 times of weight, filter centrifugal removing slag, be condensed into clear paste, again by Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus is dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
4. the preparation method of pharmaceutical composition as claimed in claim 1, it is characterized in that weighing each taste crude drug by described pharmaceutical composition crude drug composition, first by the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus adds the decocting 2.5-3.5 hour of 13-17 times of weight, filter centrifugal removing slag, be condensed into clear paste, again by Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus is dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
5. preparation method as claimed in claim 4, it is characterized in that weighing each taste crude drug by described pharmaceutical composition crude drug composition, first by the Radix Astragali, Ramulus Cinnamomi, Radix Saposhnikoviae, the Radix Angelicae Dahuricae, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Cyathulae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Caulis Spatholobi, Rhizoma Gastrodiae, Folium Isatidis, Retinervus Luffae Fructus adds the decocting 3 hours of 15 times of weight, filter centrifugal removing slag, be condensed into clear paste, again by Radix Notoginseng, Pheretima, Scolopendra, Bombyx Batryticatus is dried and crushed into fine powder, mix homogeneously with above-mentioned clear paste, finally add conventional adjuvant, according to common process, make tablet, capsule, powder, pill, granule, unguentum or oral liquid.
6. the preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that in pharmaceutical composition, adding conventional adjuvant, according to common process, makes slow releasing preparation, quick releasing formulation or controlled release preparation.
7. the application of pharmaceutical composition as claimed in claim 1 in the medicine of preparing facial paralysis.
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| CN103933091A (en) * | 2014-05-08 | 2014-07-23 | 唐海玉 | Medicament for treating facial paralysis |
| CN105833104A (en) * | 2016-06-02 | 2016-08-10 | 烟台民望机电技术有限公司 | Pharmaceutical composition for treating facial paralysis and preparation method thereof |
| CN106266356A (en) * | 2016-11-11 | 2017-01-04 | 东莞市百替生物科技有限公司 | A kind of Chinese medicine preparation treating facial paralysis and preparation method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146343C (en) * | 1997-02-14 | 2004-04-21 | Seb公司 | Electric appliance for grilling or heating flat slice of food |
| CN101991780A (en) * | 2009-08-13 | 2011-03-30 | 萧百川 | Chinese material medical preparation for treating apoplexy |
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| CN1063945C (en) * | 1995-09-25 | 2001-04-04 | 石建民 | External compress paste for discopathy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1146343C (en) * | 1997-02-14 | 2004-04-21 | Seb公司 | Electric appliance for grilling or heating flat slice of food |
| CN101991780A (en) * | 2009-08-13 | 2011-03-30 | 萧百川 | Chinese material medical preparation for treating apoplexy |
Non-Patent Citations (1)
| Title |
|---|
| 刘有明，水思源.中药配合针刺治疗周围性面瘫34例临床观察.《中国医药科学》.2012,第2卷(第19期),第82页左栏第2段，右栏第1段. * |
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