CN103007063B - A pharmaceutical composition for treating facial paralysis, and its preparation method - Google Patents

Abstract

The invention provides a pharmaceutical composition for treating facial paralysis, which consists of astragalus, cassia twig, divaricate saposhnikovia root, dahurian angelica root, Szechuan lovage rhizome, red paeony root, medicinal cyathula root, ginger processed pinellia tuber, loofah sponge, tall gastrodia tuber, pseudo-ginseng, earthworm, centipede, stiff silkworm, suberect spatholobus stem and indigowoad leaf. The pharmaceutical composition is prepared into clinically acceptable formulations by adding conventional auxiliary materials according to a conventional process. The pharmaceutical composition has remarkable effect of treating facial paralysis and no side effect.

Description

A kind of pharmaceutical composition for treating facial paralysis and preparation method thereof

technical field

The invention belongs to the field of medicine, and relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating facial paralysis.

Background technique

Facial paralysis is a common clinical disease and belongs to the categories of diseases such as "crooked mouth", "crooked mouth" and "hanging thread wind" in traditional Chinese medicine. Traditional Chinese medicine believes that the disease is mostly caused by the emptiness of the veins and the invasion of wind and cold, resulting in blockage of meridian qi, disharmony of qi and blood, and stasis of the meridians, resulting in the loss of nourishment of the meridians and slow muscle contraction, thus causing various symptoms.

The main symptoms of facial paralysis are sudden paralysis of one side of the face, inability to close the eyelids, tearing, disappearance of facial expressions, slurred speech, leakage of food and water during meals, disappearance of forehead lines, inability to frown, frown, bulge cheeks, show teeth and Whistling and other actions, the nasolabial folds become shallower. When the patient closes his eyes, the eyeball on the affected side turns outward and upward, often exposing the white sclera.

At present, clinically, western medicine treats this disease with three types of drugs: antiviral drugs, glucocorticoids, and neurotrophic drugs. Since the pathogenesis of facial paralysis itself is not yet fully understood, these drugs have unclear targets, limited effects, single curative effect, low effective rate, easy recurrence after healing, and prominent side effects of some drugs.

Traditional Chinese medicine often adopts dialectical treatment methods. There are various prescriptions for treating facial paralysis, capsules, external application of ointment for treating facial paralysis or addition and subtraction of other prescriptions, and acupuncture and moxibustion. Obvious shortcomings, acupuncture and moxibustion treatment has certain limitations on the treatment place and time, and has some shortcomings such as pain, so it is difficult to be recognized and accepted by patients.

Contents of the invention

The object of the invention is to provide a pharmaceutical composition for treating facial paralysis and a preparation method thereof.

Another object of the present invention is to provide a new application of the pharmaceutical composition.

The present invention is achieved through the following technical solutions:

The bulk drug of the pharmaceutical composition of the present invention consists of:

Astragalus 15-50 parts by weight, Guizhi 4-12 parts by weight, Fangfeng 4-10 parts by weight, Angelica dahurica 8-15 parts by weight, Rhizoma Chuanxiong 6-12 parts by weight, Radix Paeoniae Rubra 12-18 parts by weight, Achyranthes bidentata 8-15 parts by weight Parts by weight, 4-10 parts by weight of Pinellia ginger, 8-15 parts by weight of loofah, 3-9 parts by weight of Gastrodia elata, 3-9 parts by weight of Panax notoginseng, 10-15 parts by weight of earthworm, 3-9 parts by weight of centipede, silkworm 4-12 parts by weight, 15-25 parts by weight of Caulis Spatholobus, and 8-20 parts by weight of Folium Folium.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

30 parts by weight of astragalus, 6 parts by weight of cassia twig, 6 parts by weight of Fangfeng, 10 parts by weight of Angelica dahurica, 10 parts by weight of Chuanxiong, 15 parts by weight of red peony, 10 parts by weight of Achyranthes chinensis, 6 parts by weight of Jiang Pinellia, 10 parts by weight of loofah, 6 parts by weight of Gastrodia elata, 6 parts by weight of Panax notoginseng, 12 parts by weight of earthworm, 6 parts by weight of centipede, 6 parts by weight of silkworm, 20 parts by weight of Caulis Spatholobus, and 12 parts by weight of Folium folium.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

20 parts by weight of astragalus, 8 parts by weight of cassia twig, 9 parts by weight of Fangfeng, 10 parts by weight of Angelica dahurica, 7 parts by weight of Chuanxiong, 15 parts by weight of red peony, 12 parts by weight of Achyranthes chinensis, 7 parts by weight of Pinellia ginger, 8 parts by weight of loofah, 5 parts by weight of Gastrodia elata, 9 parts by weight of Panax notoginseng, 13 parts by weight of earthworm, 4 parts by weight of centipede, 8 parts by weight of silkworm, 24 parts by weight of Caulis Spatholobus, and 13 parts by weight of Daqingye.

The bulk drug composition of the pharmaceutical composition of the present invention is preferably composed of:

45 parts by weight of astragalus, 5 parts by weight of cassia twig, 7 parts by weight of Fangfeng, 14 parts by weight of Angelica dahurica, 7 parts by weight of Chuanxiong, 16 parts by weight of red peony, 11 parts by weight of Achyranthes chinensis, 5 parts by weight of Pinellia ginger, 10 parts by weight of loofah, 8 parts by weight of Gastrodia elata, 4 parts by weight of Panax notoginseng, 11 parts by weight of earthworm, 8 parts by weight of centipede, 5 parts by weight of silkworm, 18 parts by weight of Caulis Spatholobus, and 18 parts by weight of Daqingye.

According to the composition of the pharmaceutical composition raw material medicine of the present invention, each raw material medicine is weighed, and first astragalus, osmanthus twig, windproof, angelica dahurica, chuanxiong, red peony root, achyranthes bidentata, ginger Pinellia, Mildew Spatholobus, Gastrodia elata, Daqingye, loofah Add 13-17 times the weight of water and decoct for 2.5-3.5 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally Add conventional excipients, according to conventional technology, make tablet, capsule, powder, pill, granule, ointment or oral liquid preparation.

Preferably, according to the composition of the raw materials of the pharmaceutical composition of the present invention, each flavor of the raw materials is weighed; Add 15 times the weight of loofah and decoct in water for 3 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and grind Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add Conventional excipients are made into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations according to conventional processes.

The bulk drug of the pharmaceutical composition of the present invention is prepared by adding conventional excipients and following conventional techniques to prepare sustained-release preparations, immediate-release preparations or controlled-release preparations.

The property of medicine of the selected Chinese herbal medicine and pharmacology of the present invention are respectively:

Radix Astragali: sweet, slightly warm. Invigorate the middle and replenish qi, stop perspiration, promote diuresis and reduce swelling, detoxify and promote granulation.

Cinnamon Twig: pungent, sweet. temperature. Sweating relieves the surface, warms the meridians to relieve pain, and helps yang transform qi.

Windproof: pungent, sweet, slightly warm. Expelling wind and relieving exterior syndrome, eliminating dampness and relieving pain, relieving spasm.

Angelica dahurica: pungent, warm in nature. Expelling wind, drying dampness, detumescence, relieving pain.

Gastrodia elata: sweet, flat. Expelling wind to relieve spasm, calming liver-yang, dispelling wind and dredging collaterals.

Rhizoma Chuanxiong: pungent, warm, fragrant and dry. Promoting blood circulation and promoting qi, expelling wind and relieving pain, dispelling stagnation and dampness.

Radix Paeoniae Rubra: bitter, slightly cold. Promote blood stasis, relieve pain, cool blood, detumescence.

Radix Notoginseng: sweet, slightly bitter, slightly warm. Stop bleeding and remove blood stasis, reduce swelling and relieve pain.

Radix Achyranthes Radix: sweet, slightly bitter, flat. Promoting blood circulation to stimulate menstrual flow, dispelling wind and removing dampness, inducing diuresis and treating stranguria syndrome.

Earth Dragon: into, cold. Clearing away heat and calming liver, quenching wind and relieving convulsion, relieving asthma, diuresis, dredging collaterals and eliminating numbness.

Centipede: pungent, temperature. Expelling wind and relieving spasm, attacking poison and dispelling stagnation, dredging collaterals to relieve pain.

Pinellia Ginger: pungent, warm. Warming middle-JIAO and resolving phlegm, reducing adverse flow and relieving vomiting.

Spatholobus Spatholobus: bitter, sweet, warm. Enriching blood, invigorating blood circulation, dredging collaterals.

Loofah: sweet, cool. dredging collaterals, promoting blood circulation, expelling wind.

Bombyx mori: pungent, Cheng, tepor. Dispelling wind and relieving spasm, resolving phlegm and resolving stagnation.

Folium Folium: bitter, severe cold. Heat-clearing and toxic substances removing, cooling blood and eliminating spots.

Combining the pharmacology and medicinal properties of the above raw materials, through a large number of studies and repeated clinical treatment studies, the pharmaceutical composition of the present invention has been developed. The pharmaceutical composition of the present invention has a significant effect in treating facial paralysis and has no side effects. Collateral, promoting blood circulation and expelling wind, benefiting qi and nourishing blood. The pharmaceutical composition of the invention can achieve the effect of treating both symptoms and root causes of facial paralysis, eliminate clinical symptoms, and finally achieve the purpose of curing.

The following experiments and specific embodiments are used to further illustrate but not limit the present invention.

Experimental example

Experimental example 1

Among the 68 facial paralysis patients treated with the pharmaceutical composition of the present invention, 41 were males and 27 were females. The course of the disease was as short as 2 weeks and as long as 2 years.

Judgment of curative effect: According to the "Criteria for Diagnosis and Curative Effect of Diseases of Traditional Chinese Medicine" promulgated by the State Administration of Traditional Chinese Medicine in 1994, 3-level standards are adopted.

Recovery: Eyes closed well, forehead lines and nasolabial folds on both sides symmetrical, bulging cheeks and teeth showing without obstacles.

Significant effect: forehead lines and nasolabial folds on both sides are basically symmetrical, eyes closed and teeth showing are slightly impaired.

Invalid: The forehead lines and the nasolabial folds on both sides are obviously asymmetrical, and the eyes are closed and the teeth are seriously obstructed.

The treatment results are shown in the table below:

Above-mentioned clinical research shows: among the 68 facial paralysis patients treated by the pharmaceutical composition of the present invention, 4 weeks after treatment, 61 cases were cured, 4 cases were effective, and 3 cases were ineffective, and the effective rate reached 95.6%.

Embodiment 1-Embodiment 9 can all realize the effect of Experimental Example 1.

Experimental example 2

Case: Zhang, female, 42 years old, had sudden drooping of the right corner of the mouth for 1 day.

Physical examination: eyelids could not be closed, facial expressions disappeared, right forehead lines disappeared, and right nasolabial fold became shallower.

Diagnosis: Facial paralysis caused by fatigue and cold.

Treatment: take acyclovir 0.2tid, prednisone 10mg qd, mecobalamin 500ug bid, treat for 4 days, the symptom improvement is not obvious, take the pharmaceutical composition of the embodiment of the present invention 2 times every day, the 3rd day, symptom The improvement was obvious, and after taking it for 1 week, the facial paralysis basically disappeared. Consolidate and recover from illness after taking 1 week.

Experimental example 3

Case: Li Moumou, female, 21 years old, a student at school, was tired and slept on a bus blowing cold wind. When she got up the next morning, she found that her eyes were not fully closed, the corners of her mouth were crooked, and her face was numb. Diagnose facial paralysis, take methylcobalamin 500ug bid and treat for 4 days, the symptom improvement is not obvious, take the pharmaceutical composition of the embodiment of the present invention 2 every day 2 times, on the 5th day, the symptom improvement is obvious, fully recover after serving on 2 weeks.

Experimental example 4

Case Sun, male, 43 years old, suffered from cold after taking a bath, felt facial numbness after getting up the next morning, found that the corners of the mouth were crooked, and could not bulge his cheeks. Diagnose facial paralysis, take the pharmaceutical composition of the embodiment of the present invention 3 every day 2 times, on the 7th day, symptom improvement is obvious, fully recover after serving on 3 weeks.

Experimental example 5

Case Lee, man, 72 years old, suffers from the cold because of sleeping with the window open at night, feels facial numbness after getting up the next morning, finds that the corners of the mouth are crooked, leaks when drinking water, and is diagnosed with facial paralysis, takes the pharmaceutical composition of the embodiment of the present invention 2 times a day, On the 10th day, the symptoms improved significantly, and he recovered after taking it for 3 weeks.

Experimental example 6

Case Han, female, 70 years old, suffered a cold due to fatigue, and found that the corners of the mouth were crooked and facial numbness after waking up the next morning. Diagnose facial paralysis, take the pharmaceutical composition of the embodiment of the present invention 5 every day 2 times, the 8th day, symptom improvement is obvious, fully recover after serving on 4 weeks.

Experimental example 7

Case Wang, female, 76 years old, after catching cold, found that the corners of the mouth were crooked, forehead lines disappeared, and facial numbness after getting up the next morning. Diagnose facial paralysis, take the pharmaceutical composition of the embodiment of the present invention 6 every day 2 times, after 1 week, symptom improvement, even served on 5 weeks after recovery from illness.

Detailed ways

Example 1

Astragalus 30g, Guizhi 12g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuanxiong 10g, Jiangpinellia 6g, Loofah 10g, Gastrodia elata 6g, Panax notoginseng 6g, Dilong 12g, Centipede 6g, Bombyx mori 6g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 13 times the weight in water for 2.5 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional technology, made into oral liquid preparations.

Example 2

Astragalus 50g, Guizhi 12g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuanxiong 10g, Jiangpinellia 6g, Loofah 10g, Gastrodia elata 6g, Panax notoginseng 6g, Dilong 12g, Centipede 6g, Silkworm 6g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 14 times its weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional process, made into pills.

Example 3

Astragalus 30g, Guizhi 12g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuan Achyranthes bidentata 15g, Jiang Pinellia 6g, Loofah 15g, Gastrodia elata 9g, Panax notoginseng 6g, Dilong 12g, Centipede 6g, Silkworm 6g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 16 times its weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional process, made into powder.

Example 4

Astragalus 30g, Guizhi 6g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuanxiong 10g, Jiangpinellia 6g, Loofah 10g, Gastrodia elata 9g, Panax notoginseng 6g, Dilong 15g, Centipede 6g, Bombyx mori 6g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 17 times its weight in water for 3.5 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional process, made into granules.

Example 5

Astragalus 30g, Guizhi 6g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuanxiong 10g, Jiangpinellia 6g, Loofah 10g, Gastrodia elata 6g, Panax notoginseng 6g, Dilong 12g, Centipede 9g, Silkworm 12g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 15 times the weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional technology, made into capsules.

Example 6

Astragalus 30g, Guizhi 6g, Fangfeng 6g, Angelica dahurica 15g, Chuanxiong 10g, Chishao 15g, Achyranthes achyranthes 10g, Jiang Pinellia 6g, Loofah 10g, Gastrodia elata 6g, Panax notoginseng 6g, Dilong 12g, Centipede 6g, Silkworm 6g, Millet Spatholobus 20g, Daqingye 20g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 14 times its weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional process, made into ointment.

Example 7

Astragalus 30g, Guizhi 6g, Fangfeng 6g, Angelica dahurica 10g, Chuanxiong 10g, Chishao 15g, Chuanxiong 10g, Jiangpinellia 6g, Loofah 10g, Gastrodia elata 6g, Panax notoginseng 6g, Dilong 12g, Centipede 6g, Bombyx mori 6g, Millet Spatholobus 20g, Daqingye 12g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 16 times its weight in water for 3.5 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional technology, made into oral liquid preparations.

Example 8

Astragalus 20g, Guizhi 8g, Fangfeng 9g, Angelica dahurica 10g, Chuanxiong 7g, Chishao 15g, Achyranthes achyranthes 12g, Jiang Pinellia 7g, Loofah 8g, Gastrodia elata 5g, Panax notoginseng 9g, Dilong 13g, Centipede 4g, Bombyx mori 8g, Millet Spatholobus 24g, Daqingye 13g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 13 times its weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional technology, made into tablets.

Example 9

Astragalus 45g, Guizhi 5g, Fangfeng 7g, Angelica dahurica 14g, Chuanxiong 7g, Chishao 16g, Chuanxiong 11g, Jiangpinellia 5g, Loofah 10g, Gastrodia elata 8g, Panax notoginseng 4g, Dilong 11g, Centipede 8g, Silkworm 5g, Spatholobus 18g, Daqingye 18g.

According to the composition of the raw materials of the above-mentioned pharmaceutical composition, take various raw materials by weighing. Decoct 15 times the weight in water for 3 hours, filter and centrifuge to remove slag, concentrate into a clear paste, then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm into fine powder, mix with the above clear paste, and finally add conventional auxiliary materials, according to Conventional technology, made into controlled release preparations.

Claims (7)

1. a pharmaceutical composition for the treatment of facial paralysis, characterized in that the pharmaceutical composition bulk drug consists of: 30 parts by weight of astragalus, 6 parts by weight of cassia twig, 6 parts by weight of Fangfeng, 10 parts by weight of Angelica dahurica, 10 parts by weight of Chuanxiong, 15 parts by weight of red peony, 10 parts by weight of Achyranthes chinensis, 6 parts by weight of Jiang Pinellia, 10 parts by weight of loofah, 6 parts by weight of Gastrodia elata, 6 parts by weight of Panax notoginseng, 12 parts by weight of earthworm, 6 parts by weight of centipede, 6 parts by weight of silkworm, 20 parts by weight of Caulis Spatholobus, and 12 parts by weight of Folium folium. 2. The pharmaceutical composition as claimed in claim 1, characterized in that, according to the composition of the pharmaceutical composition crude drug, each taste crude drug is taken by weighing, and the astragalus, cassia twig, Radix Radix Radix Radix, Radix Cinnamon Twig, Fangfeng, Angelica dahurica, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Chuanniu Add 13-17 times the weight of water to decoct knee knee, ginger Pinellia, Millipede vine, Gastrodia elata, Daqingye, and loofah for 2.5-3.5 hours, filter and centrifuge to remove residue, concentrate into a clear paste, and then add Panax notoginseng, earthworm, centipede, Bombyx mori is dried and crushed into fine powder, mixed evenly with the above-mentioned clear paste, finally added with conventional auxiliary materials, and made into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations according to conventional processes. 3. The pharmaceutical composition as claimed in claim 2, wherein it is characterized in that the raw materials of different flavors are weighed according to the composition of the raw materials of the pharmaceutical composition. Add 15 times the weight of water to decoct the knee joint, ginger pinellia, gallinaceae, Gastrodia elata, big green leaves, and loofah in water for 3 hours, filter and centrifuge to remove residue, concentrate into a clear paste, and then dry and pulverize Panax notoginseng, earthworm, centipede, and silkworm Fine powder, mixed evenly with the above-mentioned ointment, finally adding conventional auxiliary materials, according to the conventional process, made into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations. 4. The preparation method of pharmaceutical composition as claimed in claim 1, it is characterized in that according to the composition of described pharmaceutical composition raw material medicine, each flavor raw material medicine is taken by weighing, first Radix Astragali, Guizhi, Fangfeng, Angelica dahurica, Rhizoma Chuanxiong, Radix Paeoniae Rubra , Chuan Achyranthes bidentata, Jiang Pinellia, Gallis Spatholobus, Gastrodia elata, Daqingye, and loofah add 13-17 times the weight of water and decoct for 2.5-3.5 hours, filter and centrifuge to remove residue, concentrate into a clear paste, and then add Panax notoginseng and Earthworm , centipede, and silkworm are dried and pulverized into fine powder, mixed evenly with the above clear paste, finally added with conventional auxiliary materials, and made into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations according to conventional processes. 5. the preparation method as claimed in claim 4 is characterized in that according to the composition of described pharmaceutical composition raw material medicine, weighs each flavor raw material medicine, earlier Radix Astragali, Guizhi, Fangfeng, Angelica dahurica, Rhizoma Chuanxiong, Radix Paeoniae Rubra, Radix Achyranthes Radix , Jiang Pinellia, Millipede Spatholobus, Gastrodia elata, Daqingye, loofah, add 15 times the weight of water and decoct for 3 hours, filter and centrifuge to remove residue, concentrate into a clear paste, then dry and grind Panax notoginseng, earthworm, centipede, and silkworm into Fine powder, mixed evenly with the above-mentioned clear paste, finally added with conventional auxiliary materials, according to conventional processes, made into tablets, capsules, powders, pills, granules, ointments or oral liquid preparations. 6. The preparation method of pharmaceutical composition as claimed in claim 1, is characterized in that adding conventional adjuvant in pharmaceutical composition, according to conventional technology, is made sustained-release preparation, quick-release preparation or controlled-release preparation. 7. the application of pharmaceutical composition as claimed in claim 1 in the medicine of preparation treatment facial paralysis.