CN106266356A - A kind of Chinese medicine preparation treating facial paralysis and preparation method - Google Patents

A kind of Chinese medicine preparation treating facial paralysis and preparation method Download PDF

Info

Publication number
CN106266356A
CN106266356A CN201610992038.0A CN201610992038A CN106266356A CN 106266356 A CN106266356 A CN 106266356A CN 201610992038 A CN201610992038 A CN 201610992038A CN 106266356 A CN106266356 A CN 106266356A
Authority
CN
China
Prior art keywords
parts
radix
raw
standby
powder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201610992038.0A
Other languages
Chinese (zh)
Inventor
黄烜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dongguan Biological Technology Co Ltd
Original Assignee
Dongguan Biological Technology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dongguan Biological Technology Co Ltd filed Critical Dongguan Biological Technology Co Ltd
Priority to CN201610992038.0A priority Critical patent/CN106266356A/en
Publication of CN106266356A publication Critical patent/CN106266356A/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/62Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/646Arachnids, e.g. spiders, scorpions, ticks or mites
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/648Myriapods, e.g. centipedes or millipedes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286Carthamus (distaff thistle)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/42Cucurbitaceae (Cucumber family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0087Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/39Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50Methods involving additional extraction steps
    • A61K2236/53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

nullThe invention discloses a kind of Chinese medicine preparation treating facial paralysis and preparation method,It is made up of the raw material of following weight portion: Rhizoma Typhonii 60 120 parts、Bombyx Batryticatus 90 150 parts、The Radix Angelicae Dahuricae 90 150 parts、Radix Saposhnikoviae 90 150 parts、Scolopendra 30 90 parts、Scorpio 30 90 parts、Ramulus Uncariae Cum Uncis 170 230 parts、Fructus Liquidambaris 170 230 parts、Rhizoma Arisaematis (processed) 50 110 parts、The Radix Astragali 200 400 parts、70 130 parts of Flos Carthami、Pheretima 120 180 parts、Rhizoma Chuanxiong 120 180 parts、60 120 parts of Radix Glycyrrhizae、Radix Rehmanniae 120 180 parts、Radix Paeoniae Rubra 120 180 parts、Radix Angelicae Sinensis 120 180 parts、Retinervus Luffae Fructus 60 120 parts、Stevioside 0.001 0.002 parts、Sodium benzoate 0.001 0.003 parts.The present invention has dispelling wind and removing obstruction in the collateral, effect promoted blood circulation of reducing phlegm, and drug effect is notable, can be with long-term taking, and patient is prone to accept.

Description

A kind of Chinese medicine preparation treating facial paralysis and preparation method
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine preparation treating facial paralysis and preparation method.
Background technology
Facial paralysis, is called for short facial paralysis, formal name used at school facial paralysis, and also referred to as facial neuritis, bell's palsy, Hunter is comprehensive Disease, is commonly called as " wapperijaw bar ", " wapperijaw ", " facial paralysis ", " hanging skew wind ", " facial neuritis ", " wapperijaw wind " etc., is with facial expression Muscle group dyskinesia is a kind of commonly encountered diseases of principal character, and general symptom is facial hemiparalysis, is a kind of commonly encountered diseases, multiple Disease, it is not limited by age and sex, what patient facial region was the most most basic lift eyebrow, close one's eyes, the drum cheek, the action such as pout one's lips as a signal all cannot Complete;Clinical manifestation majority patient washes one's face the most in the morning, catch sight of that side buccal action is ineffective, face is crooked when gargling, The sick complete paralytic of side surface part histrionic muscles, forehead line disappears, palpebral fissure expands, nasolabial fold is smooth, ptosis of labial angle, bicker time grinningly Askew to strong lateral deviation, can not make wrinkle volume, frown, close mesh, air-blowing and the action such as be in a pout in sick side, the drum cheek and when whistling, because of Ipsilateral mouth Lip can not close and leak gas, and during feed, food debris is often stranded in the tooth buccal space of disease side, and often has saliva to drop down from this side Under, owing to lacrimal point is with lower eyelid entropion, make the tear can not be excessive by normal drainage;Chinese medicine facial paralysis research at present Report increasing, utilize modern science and technology equipment and method, inquire into facial paralysis etiology and pathogenesis, screening verification active drug, Develop with strong points, curative effect affirmative, the Chinese medicine preparation of dosage form simplicity, be key issue the most urgently to be resolved hurrily.
Summary of the invention
For solving above-mentioned technical problem, the present invention provides a kind of Chinese medicine preparation treating facial paralysis, by following weight The raw material of part is made: Rhizoma Typhonii 60-120 part, Bombyx Batryticatus 90-150 part, Radix Angelicae Dahuricae 90-150 part, Radix Saposhnikoviae 90-150 part, Scolopendra 30-90 Part, Scorpio 30-90 part, Ramulus Uncariae Cum Uncis 170-230 part, Fructus Liquidambaris 170-230 part, Rhizoma Arisaematis (processed) 50-110 part, Radix Astragali 200-400 part, red Flower 70-130 part, Pheretima 120-180 part, Rhizoma Chuanxiong 120-180 part, Radix Glycyrrhizae 60-120 part, Radix Rehmanniae 120-180 part, Radix Paeoniae Rubra 120- 180 parts, Radix Angelicae Sinensis 120-180 part, Retinervus Luffae Fructus 60-120 part, stevioside 0.001-0.002 part, sodium benzoate 0.001-0.003 part;
The present invention also provides for the preparation method of a kind of Chinese medicine preparation treating facial paralysis, and its preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100-120 mesh, obtain raw material powder, standby With;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60-80 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80-100 mesh, obtain raw material powder, standby With;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 8-12 times, soaks 0.5-2 hour, adds thermal distillation 2-6 hour, collects volatile oil, obtains distillate, and medicinal residues add raw material gross weight The soak by water of 4-8 times of amount 1-2 time, the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters to obtain filter Liquid, filtrate is concentrated into 85-95 DEG C and surveys relative density is the clear paste of 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling Even, 0 to 6 DEG C of cold preservation 20-30 hour, filter, decompression filtrate recycling ethanol to without alcohol taste, filtrate be concentrated into 50-60 DEG C the closeest Degree is the extractum of 1.15-1.25, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 3-6 times amount is heated to boiling, Stir 15-25 minute, micro-boiling insulation 10-15 minute, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 500-600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then regulate pH For 6.5-7.0, obtain dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
Preferably in scheme, described a kind of Chinese medicine preparation treating facial paralysis, by the raw material system of following weight portion Become: Rhizoma Typhonii 90 parts, Bombyx Batryticatus 120 parts, the Radix Angelicae Dahuricae 120 parts, Radix Saposhnikoviae 120 parts, Scolopendra 60 parts, Scorpio 60 parts, Ramulus Uncariae Cum Uncis 200 parts, Lu Lu Logical 200 parts, Rhizoma Arisaematis (processed) 80 parts, the Radix Astragali 300 parts, 100 parts of Flos Carthami, Pheretima 150 parts, Rhizoma Chuanxiong 150 parts, 90 parts of Radix Glycyrrhizae, Radix Rehmanniae 150 Part, Radix Paeoniae Rubra 150 parts, Radix Angelicae Sinensis 150 parts, Retinervus Luffae Fructus 90 parts, stevioside 0.0015 part, sodium benzoate 0.002 part;
Its preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100 mesh, obtain raw material powder, standby;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80 mesh, obtain raw material powder, standby;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 12 times, soaks 0.5 hour, adds thermal distillation 4 hours, collects volatile oil, obtains distillate, and medicinal residues add the 8 of raw material gross weight Soak by water again 2 times, the time is 0.6 hour, merges decoction liquor and volatile oil and distillate, filters to get filtrate, and filtrate is concentrated into 85 DEG C are surveyed relative densities is the clear paste of 1.00, adds 85% appropriate amount of ethanol, stir evenly after cooling, 5 DEG C of cold preservation 20 hours, filters, filtrate Decompression recycling ethanol is to without alcohol taste, and it is the extractum of 1.25 that filtrate is concentrated into 60 DEG C of relative densities, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 6 times amount is heated to boiling, stirs Mix 15 minutes, micro-boiling insulation 10 minutes, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15 minutes, at 60 DEG C, under the conditions of 20MPa, carry out twice homogenization, then to regulate pH be 7.0, To dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
Used by the present invention, the pharmacology of raw material of Chinese medicine medicine is as follows:
Rhizoma Typhonii: meridian distribution of property and flavor: pungent, sweet is the warmmest;Poisonous, GUIXIN, kidney, spleen channel;Function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, By wind-cold damp pathogen;Collapsing for YANG-depletion, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness vomiting and diarrhoea, YIN-cold edema, outside yang deficiency Sense, arthralgia due to cold-dampnes.
Bombyx Batryticatus: meridian distribution of property and flavor: salty, pungent, flat, return liver, lung, stomach warp;Function cures mainly: expelling wind for relieving convulsion, dissipating phlegm and resolving masses;For shying Wind is twitched, laryngopharynx swelling and pain, skin pruritus, and submandibular lymph nodes is scorching, facial paralysis.
The Radix Angelicae Dahuricae: meridian distribution of property and flavor: pungent, temperature, return stomach, large intestine, lung meridian;Function cures mainly: dissipate wind dehumidifying, sensible pain relieving, detumescence row Pus;For headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Saposhnikoviae: meridian distribution of property and flavor: acrid, sweet, warm, returns bladder, liver, spleen channel;Function cures mainly: inducing diaphoresis to dispel wind, wins wet, relieving convulsion;With In headache due to common cold, rheumatic arthralgia, rubella pruritus, tetanus.
Scolopendra: meridian distribution of property and flavor: pungent, temperature;Poisonous, return Liver Channel;Function cures mainly: endogenous wind stopping spasmolytic, merit poison eliminating stagnation, removing obstruction in the collateral to relieve pain; For infantile convulsion, tic spasm, middle air port Guo, hemiplegia, tetanus, rheumatoid arthritis stubborn, skin infection, scrofula, venom.
Scorpio: meridian distribution of property and flavor: pungent, flat;Poisonous, return Liver Channel;Function cures mainly: endogenous wind stopping spasmolytic, dispersing pathogen accumulation, removing obstruction in the collateral to relieve pain; For infantile convulsion, tic spasm, middle air port Guo, hemiplegia, tetanus, rheumatoid arthritis stubborn, migraine and general headache, skin infection, scrofula.
Ramulus Uncariae Cum Uncis: meridian distribution of property and flavor: sweet, cool, return liver, pericardium channel;Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion;Dizzy for having a headache Dizzy, dysphoric cold, infantile convulsion tic, pre-eclampsia, hypertension.
Fructus Liquidambaris: meridian distribution of property and flavor: bitter, flat, return liver, kidney channel;Function cures mainly: dispelling, collateral-activating, and diuretic stimulates the menstrual flow;For joint numbness Bitterly, numbness contracture, edema distension, the few amenorrhea of breast.
Rhizoma Arisaematis (processed): meridian distribution of property and flavor: bitter, pungent, temperature;Poisonous, return lung, liver, spleen channel;Function cures mainly: drying dampness to eliminate phlegm, only dispels the wind Convulsion, mass dissipating and swelling eliminating;Cough for pertinacious phlegm, dizziness due to wind-phlegm, the heap soil or fertilizer over and around the roots of middle wind-phlegm, facial hemiparalysis, hemiplegia, epilepsy, infantile convulsion, broken wound Wind;External treatment carbuncle, snake bite and insect sting are used in life.
The Radix Astragali: meridian distribution of property and flavor: sweet, temperature, return lung, spleen channel;Function cures mainly: invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, and sore is raw Flesh;Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult Bursting, burst for a long time and do not hold back, blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst;Chronic nephritis proteinuria, diabetes.
Flos Carthami: meridian distribution of property and flavor: pungent, temperature, GUIXIN, Liver Channel;Function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain;For amenorrhea, bitterly Warp, lochia, note of the ancient Chinese abdominal mass mass in the abdomen, injury from falling down, skin infection swells and ache.
Pheretima: meridian distribution of property and flavor: salty, cold, return liver, spleen, bladder warp;Function cures mainly: heat clearing away is calmed the frightened, and dredging collateral is relievingd asthma, diuresis; For unconsciousness due to high fever, infantile convulsion is twitched, arthralgia, numb limbs and tense tendons, hemiplegia, dyspnea and cough due to lung-heat, oliguria edema, hypertension.
Rhizoma Chuanxiong: meridian distribution of property and flavor: pungent, temperature, return liver, gallbladder, pericardium channel;Function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping;For the moon Through uncomfortable, amenorrhea dysmenorrhea, abdominal mass stomachache, breast side of body twinge, tumbling and swelling, headache, rheumatic arthralgia.
Radix Glycyrrhizae: property is flat, sweet in the mouth, GUIXIN, spleen, lung, stomach warp;Effect: tonification;Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, Expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription;For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, extremity Contraction urgency pain, carbuncle sore tumefacting virus, cushion toxicity, strong.
Radix Rehmanniae: meridian distribution of property and flavor: sweet, bitter, cold, GUIXIN, liver, kidney channel;Effect: clearing away heat and cooling blood, YIN nourishing and the production of body fluid promoting;Cure mainly: use Vexed in calentura, crimson tongue, heat in blood tells nosebleed, and macule purple is black, consumption of YIN caused by febrile disease, polydipsia of quenching one's thirst.
Radix Paeoniae Rubra: meridian distribution of property and flavor: bitter, is slightly cold, returns Liver Channel;Function cures mainly: clearing away heat and cooling blood, eliminating stasis to stop pain;For maculae caused by violent heat pathogen, Hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, note of the ancient Chinese abdominal mass stomachache, injury from falling down, carbuncle skin infection.
Radix Angelicae Sinensis: meridian distribution of property and flavor: sweet, acrid, warm, returns liver, the heart, spleen channel;Function cures mainly: replenishing and activating blood, menstruction regulating and pain relieving, and intestine moistening is led to Just;For blood deficiency and yellow complexion, dizziness cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, fall and flutter damage Wound, ulcer sores.
Retinervus Luffae Fructus: nature and flavor: sweet in the mouth, property is put down, is returned stomach, lung, Liver Channel;Function: dispel the wind, dredging collateral, invigorate blood circulation, effect of stimulating milk secretion; Cure mainly: being used for treating arthralgia pain contracture, distending pain in the chest and hypochondrium, galactostasis, acute mastitis swells and ache.
Beneficial effects of the present invention: have dispelling wind and removing obstruction in the collateral, effect promoted blood circulation of reducing phlegm, drug effect is notable, can suffer from long-term taking Person is prone to accept.
Detailed description of the invention
Describe technical scheme in detail below in conjunction with embodiment and experimental example, but protection domain is not limited to this.
Embodiment 1
A kind of Chinese medicine preparation treating facial paralysis, is made up of the raw material of following weight portion: Rhizoma Typhonii 120 parts, Bombyx Batryticatus 150 Part, the Radix Angelicae Dahuricae 150 parts, Radix Saposhnikoviae 150 parts, Scolopendra 90 parts, Scorpio 90 parts, Ramulus Uncariae Cum Uncis 230 parts, Fructus Liquidambaris 230 parts, Rhizoma Arisaematis (processed) 110 parts, Huang Stilbene 400 parts, 130 parts of Flos Carthami, Pheretima 180 parts, Rhizoma Chuanxiong 180 parts, 120 parts of Radix Glycyrrhizae, Radix Rehmanniae 180 parts, Radix Paeoniae Rubra 180 parts, Radix Angelicae Sinensis 180 Part, Retinervus Luffae Fructus 120 parts, stevioside 0.002 part, sodium benzoate 0.003 part;
Its preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100-120 mesh, obtain raw material powder, standby With;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60-80 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80-100 mesh, obtain raw material powder, standby With;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 8-12 times, soaks 0.5-2 hour, adds thermal distillation 2-6 hour, collects volatile oil, obtains distillate, and medicinal residues add raw material gross weight The soak by water of 4-8 times of amount 1-2 time, the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters to obtain filter Liquid, filtrate is concentrated into 85-95 DEG C and surveys relative density is the clear paste of 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling Even, 0 to 6 DEG C of cold preservation 20-30 hour, filter, decompression filtrate recycling ethanol to without alcohol taste, filtrate be concentrated into 50-60 DEG C the closeest Degree is the extractum of 1.15-1.25, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 3-6 times amount is heated to boiling, Stir 15-25 minute, micro-boiling insulation 10-15 minute, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 500-600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then regulate pH For 6.5-7.0, obtain dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
Usage: oral, every day 2 times, each 15ml.
Embodiment 2
A kind of Chinese medicine preparation treating facial paralysis, is made up of the raw material of following weight portion: Rhizoma Typhonii 90 parts, Bombyx Batryticatus 120 parts, The Radix Angelicae Dahuricae 120 parts, Radix Saposhnikoviae 120 parts, Scolopendra 60 parts, Scorpio 60 parts, Ramulus Uncariae Cum Uncis 200 parts, Fructus Liquidambaris 200 parts, Rhizoma Arisaematis (processed) 80 parts, the Radix Astragali 300 parts, 100 parts of Flos Carthami, Pheretima 150 parts, Rhizoma Chuanxiong 150 parts, 90 parts of Radix Glycyrrhizae, Radix Rehmanniae 150 parts, Radix Paeoniae Rubra 150 parts, Radix Angelicae Sinensis 150 parts, Retinervus Luffae Fructus 90 parts, stevioside 0.0015 part, sodium benzoate 0.002 part;
Its preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100-120 mesh, obtain raw material powder, standby With;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60-80 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80-100 mesh, obtain raw material powder, standby With;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 8-12 times, soaks 0.5-2 hour, adds thermal distillation 2-6 hour, collects volatile oil, obtains distillate, and medicinal residues add raw material gross weight The soak by water of 4-8 times of amount 1-2 time, the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters to obtain filter Liquid, filtrate is concentrated into 85-95 DEG C and surveys relative density is the clear paste of 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling Even, 0 to 6 DEG C of cold preservation 20-30 hour, filter, decompression filtrate recycling ethanol to without alcohol taste, filtrate be concentrated into 50-60 DEG C the closeest Degree is the extractum of 1.15-1.25, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 3-6 times amount is heated to boiling, Stir 15-25 minute, micro-boiling insulation 10-15 minute, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 500-600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then regulate pH For 6.5-7.0, obtain dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
Usage: oral, every day 2 times, each 15ml.
Embodiment 3
A kind of Chinese medicine preparation treating facial paralysis, is made up of the raw material of following weight portion: Rhizoma Typhonii 60 parts, Bombyx Batryticatus 90 parts, The Radix Angelicae Dahuricae 90 parts, Radix Saposhnikoviae 90 parts, Scolopendra 30 parts, Scorpio 30 parts, Ramulus Uncariae Cum Uncis 170 parts, Fructus Liquidambaris 170 parts, Rhizoma Arisaematis (processed) 50 parts, the Radix Astragali 200 Part, 70 parts of Flos Carthami, Pheretima 120 parts, Rhizoma Chuanxiong 120 parts, 60 parts of Radix Glycyrrhizae, Radix Rehmanniae 120 parts, Radix Paeoniae Rubra 120 parts, Radix Angelicae Sinensis 120 parts, Fructus Luffae Network 60 parts, stevioside 0.001 part, sodium benzoate 0.001 part;
Its preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100-120 mesh, obtain raw material powder, standby With;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60-80 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80-100 mesh, obtain raw material powder, standby With;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 8-12 times, soaks 0.5-2 hour, adds thermal distillation 2-6 hour, collects volatile oil, obtains distillate, and medicinal residues add raw material gross weight The soak by water of 4-8 times of amount 1-2 time, the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters to obtain filter Liquid, filtrate is concentrated into 85-95 DEG C and surveys relative density is the clear paste of 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling Even, 0 to 6 DEG C of cold preservation 20-30 hour, filter, decompression filtrate recycling ethanol to without alcohol taste, filtrate be concentrated into 50-60 DEG C the closeest Degree is the extractum of 1.15-1.25, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 3-6 times amount is heated to boiling, Stir 15-25 minute, micro-boiling insulation 10-15 minute, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 500-600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then regulate pH For 6.5-7.0, obtain dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
Usage: oral, every day 2 times, each 15ml.
Chinese medicine preparation Ureteral Calculus facial hemiparalysis patient 45 example of the present invention, clinical report is as follows:
1, physical data
Clinical observation facial hemiparalysis patient 45 example, the maleest 18 examples, female 27 example, age 25-65 year, 45 years old mean age.
2, diagnostic criteria
The clinical stage of primary disease is different, the most otherwise varied in treatment, therefore, during Syndrome Differentiation of Traditional Chinese Medicine also with above-mentioned situation is often Foundation, is divided into acute stage and convalescent period or sequela stage;
1. acute stage: it is hollow that patient mostly is venation in current period Chinese medical discrimination, obstruction of collateral caused by windphlegm, clinical common unexpected facial hemiparalysis, suffer from Side surface part expression action disappears, and deadlock is sent out in local, and forehead expands without wrinkle, palpebral fissure, and nasolabial fold shoals, slobbering, after can having ear Mastoid process pain or auditory meatus of regarding sb. as an outsider have herpes, white and greasy fur, stringy and rolling pulse;
2. convalescent period or sequela stage: though current period patient belong to more disease lose for a long time control, wrong treatment or through treatment but recuperator completely not yet, Current period Chinese medical discrimination mostly is obstruction by phlegm, and numbness resistance meridians, common clinical people still facial hemiparalysis, Ipsilateral face is sent out deadlock or has face Muscle twitches, volume stricture of vagina shoals or disappears, and palpebral fissure expands, and nasolabial fold shoals, slobbering, dark tongue quality, greasy and thin fur or thick greasy, stringy pulse Sliding.
3, Therapeutic Method
Using Chinese medicine preparation of the present invention to treat, oral Chinese medicine preparation of the present invention, every day 2 times, each 15ml, 7 days is a course for the treatment of.
4, efficacy assessment standard:
Cure: transference cure;
Take a turn for the better: clinical symptom relief;
Invalid: clinical symptoms is without improving or increasing the weight of.
5, therapeutic outcome
In clinical treatment facial hemiparalysis patient 45 example, curing 35 examples and account for 77.8%, 10 examples that take a turn for the better account for 22.2%, invalid 0 example, always Effective percentage is 100%.
6, model case
Case 1: female, 48 years old, facial paralysis sequela stage 8 years, face was askew, eyes size, and face blows afloat conjunction and do not holds together, often acid Bitterly, dark tongue quality, thick and greasy fur, stringy and rolling pulse, two courses for the treatment of of oral Chinese medicine preparation of the present invention, patient symptom substantially alleviates, oral again in Three courses for the treatment of of medicine preparation, symptom is clearly better, and of the present invention Chinese medicine preparation three courses for the treatment of, clinical cure are administered orally again.
Case 2: female, 28 years old, facial paralysis, facial hemiparalysis, right side volume stricture of vagina disappears, right eye dysraphism, drum cheek gas leakage, White and greasy fur, stringy and rolling pulse, two courses for the treatment of of oral Chinese medicine preparation of the present invention, symptom is clearly better, and of the present invention Chinese medicine preparation is administered orally again Three courses for the treatment of, clinical cure.
Case 3: man, 35 years old, facial paralysis, facial hemiparalysis, palpebral fissure becomes big, close mesh can not or bad, sick side nasolabial fold Shoal bicker deflection strong side when showing tooth, drum cheek gas leakage, dark tongue quality, thick and greasy fur, stringy and rolling pulse, oral Chinese medicine preparation of the present invention two treatment Journey, symptom is clearly better, and of the present invention Chinese medicine preparation three courses for the treatment of, clinical cure are administered orally again.
It should be pointed out that, the detailed description of the invention more representational example that is the present invention, it is clear that the skill of the present invention Art scheme is not limited to above-described embodiment, it is also possible to have many variations;Those of ordinary skill in the art, the most public with present invention institute What what that open or according to file written description was undoubted obtained, all it is considered as this patent scope of the claimed.

Claims (6)

1. the Chinese medicine preparation treating facial paralysis, it is characterised in that: it is made up of the raw material of following weight portion: Rhizoma Typhonii 60-120 part, Bombyx Batryticatus 90-150 part, Radix Angelicae Dahuricae 90-150 part, Radix Saposhnikoviae 90-150 part, Scolopendra 30-90 part, Scorpio 30-90 part, Ramulus Uncariae Cum Uncis 170-230 part, Fructus Liquidambaris 170-230 part, Rhizoma Arisaematis (processed) 50-110 part, Radix Astragali 200-400 part, Flos Carthami 70-130 part, Pheretima 120- 180 parts, Rhizoma Chuanxiong 120-180 part, Radix Glycyrrhizae 60-120 part, Radix Rehmanniae 120-180 part, Radix Paeoniae Rubra 120-180 part, Radix Angelicae Sinensis 120-180 part, Retinervus Luffae Fructus 60-120 part, stevioside 0.001-0.002 part, sodium benzoate 0.001-0.003 part.
The preparation method of a kind of Chinese medicine preparation treating facial paralysis the most according to claim 1, it is characterised in that: its Preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100-120 mesh, obtain raw material powder, standby With;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60-80 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80-100 mesh, obtain raw material powder, standby With;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 8-12 times, soaks 0.5-2 hour, adds thermal distillation 2-6 hour, collects volatile oil, obtains distillate, and medicinal residues add raw material gross weight The soak by water of 4-8 times of amount 1-2 time, the time is 0.4-0.8 hour, merges decoction liquor and volatile oil and distillate, filters to obtain filter Liquid, filtrate is concentrated into 85-95 DEG C and surveys relative density is the clear paste of 1.00-1.05, adds 85-95% appropriate amount of ethanol, stir after cooling Even, 0 to 6 DEG C of cold preservation 20-30 hour, filter, decompression filtrate recycling ethanol to without alcohol taste, filtrate be concentrated into 50-60 DEG C the closeest Degree is the extractum of 1.15-1.25, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 3-6 times amount is heated to boiling, Stir 15-25 minute, micro-boiling insulation 10-15 minute, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 500-600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15-25 minute, at 60-65 DEG C, carry out twice homogenization under the conditions of 20-30MPa, then regulate pH For 6.5-7.0, obtain dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
The preparation method of a kind of Chinese medicine preparation treating facial paralysis the most according to claim 2, it is characterised in that: its Preparation process is:
(1) take raw material Rhizoma Typhonii, Bombyx Batryticatus, the Radix Angelicae Dahuricae, the pulverizing of Radix Saposhnikoviae pulverizer, smashing fineness 100 mesh, obtain raw material powder, standby;
(2) raw material Scolopendra, Scorpio, Ramulus Uncariae Cum Uncis, Fructus Liquidambaris, Rhizoma Arisaematis (processed), the Radix Astragali, Flos Carthami, Pheretima, Rhizoma Chuanxiong, Radix Glycyrrhizae pulverizer powder are taken Broken, smashing fineness 60 mesh, obtain raw material powder, standby;
(3) take raw material Radix Rehmanniae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, the pulverizing of Retinervus Luffae Fructus pulverizer, smashing fineness 80 mesh, obtain raw material powder, standby;
(4) step (1) gained raw material powder and step (2) gained raw material powder are added raw material gross weight with (3) gained raw material powder The water of 12 times, soaks 0.5 hour, adds thermal distillation 4 hours, collects volatile oil, obtains distillate, and medicinal residues add the 8 of raw material gross weight Soak by water again 2 times, the time is 0.6 hour, merges decoction liquor and volatile oil and distillate, filters to get filtrate, and filtrate is concentrated into 85 DEG C are surveyed relative densities is the clear paste of 1.00, adds 85% appropriate amount of ethanol, stir evenly after cooling, 5 DEG C of cold preservation 20 hours, filters, filtrate Decompression recycling ethanol is to without alcohol taste, and it is the extractum of 1.25 that filtrate is concentrated into 60 DEG C of relative densities, standby;
(5) gained extractum in step (4) being put into Agitation Tank, the purified water adding extractum weight 6 times amount is heated to boiling, stirs Mix 15 minutes, micro-boiling insulation 10 minutes, form medicinal liquid, place, be cooled to room temperature, standby;
(6) take stevioside, sodium benzoate is respectively crushed into 600 mesh, standby;
(7) gained medicinal liquid in step (5) is added the stevioside after pulverizing, sodium benzoate dissolves stirring, makes medicinal liquid mix homogeneously, Filter with centrifuge after stirring 15 minutes, at 60 DEG C, under the conditions of 20MPa, carry out twice homogenization, then to regulate pH be 7.0, To dosing, standby;
(8) by the vial subpackage that gained dosing in step (7) is clean, use instantaneous ultrahigh-temperature sterilization, obtain treatment face god Chinese medicine preparation through paralysis.
A kind of Chinese medicine preparation treating facial paralysis the most according to claim 1, it is characterised in that: by following weight portion Raw material make: Rhizoma Typhonii 90 parts, Bombyx Batryticatus 120 parts, the Radix Angelicae Dahuricae 120 parts, Radix Saposhnikoviae 120 parts, Scolopendra 60 parts, Scorpio 60 parts, Ramulus Uncariae Cum Uncis 200 Part, Fructus Liquidambaris 200 parts, Rhizoma Arisaematis (processed) 80 parts, the Radix Astragali 300 parts, 100 parts of Flos Carthami, Pheretima 150 parts, Rhizoma Chuanxiong 150 parts, 90 parts of Radix Glycyrrhizae, life Radix Rehmanniae 150 parts, Radix Paeoniae Rubra 150 parts, Radix Angelicae Sinensis 150 parts, Retinervus Luffae Fructus 90 parts, stevioside 0.0015 part, sodium benzoate 0.002 part.
A kind of Chinese medicine preparation treating facial paralysis the most according to claim 1, it is characterised in that: by following weight portion Raw material make: Rhizoma Typhonii 120 parts, Bombyx Batryticatus 150 parts, the Radix Angelicae Dahuricae 150 parts, Radix Saposhnikoviae 150 parts, Scolopendra 90 parts, Scorpio 90 parts, Ramulus Uncariae Cum Uncis 230 parts, Fructus Liquidambaris 230 parts, Rhizoma Arisaematis (processed) 110 parts, the Radix Astragali 400 parts, 130 parts of Flos Carthami, Pheretima 180 parts, Rhizoma Chuanxiong 180 parts, Radix Glycyrrhizae 120 Part, Radix Rehmanniae 180 parts, Radix Paeoniae Rubra 180 parts, Radix Angelicae Sinensis 180 parts, Retinervus Luffae Fructus 120 parts, stevioside 0.002 part, sodium benzoate 0.003 part.
A kind of Chinese medicine preparation treating facial paralysis the most according to claim 1, it is characterised in that: by following weight portion Raw material make: Rhizoma Typhonii 60 parts, Bombyx Batryticatus 90 parts, the Radix Angelicae Dahuricae 90 parts, Radix Saposhnikoviae 90 parts, Scolopendra 30 parts, Scorpio 30 parts, Ramulus Uncariae Cum Uncis 170 parts, Fructus Liquidambaris 170 parts, Rhizoma Arisaematis (processed) 50 parts, the Radix Astragali 200 parts, 70 parts of Flos Carthami, Pheretima 120 parts, Rhizoma Chuanxiong 120 parts, 60 parts of Radix Glycyrrhizae, Radix Rehmanniae 120 parts, Radix Paeoniae Rubra 120 parts, Radix Angelicae Sinensis 120 parts, Retinervus Luffae Fructus 60 parts, stevioside 0.001 part, sodium benzoate 0.001 part.
CN201610992038.0A 2016-11-11 2016-11-11 A kind of Chinese medicine preparation treating facial paralysis and preparation method Pending CN106266356A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201610992038.0A CN106266356A (en) 2016-11-11 2016-11-11 A kind of Chinese medicine preparation treating facial paralysis and preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201610992038.0A CN106266356A (en) 2016-11-11 2016-11-11 A kind of Chinese medicine preparation treating facial paralysis and preparation method

Publications (1)

Publication Number Publication Date
CN106266356A true CN106266356A (en) 2017-01-04

Family

ID=57721268

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201610992038.0A Pending CN106266356A (en) 2016-11-11 2016-11-11 A kind of Chinese medicine preparation treating facial paralysis and preparation method

Country Status (1)

Country Link
CN (1) CN106266356A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101773585A (en) * 2010-02-21 2010-07-14 郑勇 Chinese medicine for treating facial paralysis
CN103007063A (en) * 2012-12-25 2013-04-03 青岛市市立医院 Medicinal composition for treating facial paralysis and preparation method thereof
CN104189306A (en) * 2014-07-26 2014-12-10 杨建平 Medicine used for treating peripheral facial neuritis
CN105412622A (en) * 2015-12-12 2016-03-23 张朝兰 Medicine for treating facial paralysis and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101773585A (en) * 2010-02-21 2010-07-14 郑勇 Chinese medicine for treating facial paralysis
CN103007063A (en) * 2012-12-25 2013-04-03 青岛市市立医院 Medicinal composition for treating facial paralysis and preparation method thereof
CN104189306A (en) * 2014-07-26 2014-12-10 杨建平 Medicine used for treating peripheral facial neuritis
CN105412622A (en) * 2015-12-12 2016-03-23 张朝兰 Medicine for treating facial paralysis and preparation method thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
匡顺华等: ""中医综合疗法治疗周围性面瘫55例疗效观察"", 《南华大学学报(医学版)》 *
姬同超等: ""中西医结合治疗面神经麻痹103例"", 《光明中医》 *
马馨等: "《百医百顺》", 31 July 2006, 黑龙江人民出版社 *

Similar Documents

Publication Publication Date Title
CN103705670A (en) Traditional Chinese medicine for dispelling wind, eliminating dampness and relieving pain and preparation method thereof
CN104043057A (en) Traditional Chinese medicinal composition for treating lymph cancer
CN104069474A (en) Traditional Chinese medicine composition for treating seborrheic alopecia and preparation method thereof
CN104189861B (en) A kind of Chinese medicine of facial paralysis
CN103599361B (en) A kind of Chinese medicine of Cure for insomnia
CN104524462A (en) Traditional Chinese medicine formula for treating craniocerebral injury or intracranial tumour postoperative vertigo
CN104189307A (en) Traditional Chinese medicine for treating deafness and tinnitus and preparation method thereof
CN103977288A (en) Medicament for treating tourette syndrome and preparation method thereof
CN103735878B (en) A kind of medicine for stroke at convalescence rehabilitation
CN106138602A (en) A kind of invigorating the kidney and strengthening the bones wine and preparation method thereof
CN103202985A (en) Traditional Chinese medicine used for treating lumbar spondylosis, cervical spondylosis, sciatica and rheumatism and preparation method thereof
CN105056164A (en) Traditional Chinese medicinal composition for treating peripheral facial paralysis
CN106266356A (en) A kind of Chinese medicine preparation treating facial paralysis and preparation method
CN104189778A (en) Traditional Chinese medicine preparation for hyperplasia of mammary glands and preparation method of traditional Chinese medicine preparation
CN106267037A (en) A kind of Chinese medicine composition treating syndrome of stagnation of liver qi and preparation method
CN103656596B (en) A kind of Chinese medicine for the treatment of liver qi stagnation syndrome cough
CN103656589B (en) Drug for treating viral myocarditis and preparation method thereof
CN105596993A (en) Traditional Chinese medicine composition for treating epilepsy
CN105535563A (en) Traditional Chinese medicine composition for treating facial neuritis and preparing method thereof
CN105381294A (en) Preparation for treating facial paralysis and preparation method thereof
CN102626503B (en) Chinese medicinal oral liquid for smoothing heart and enhancing intelligence
CN104873941A (en) Traditional Chinese medicine preparation for effectively treating nerve headache
CN104435552A (en) Oral medicine for treating open-angle glaucoma and preparation method thereof
CN104107304A (en) Traditional Chinese medicinal composition for treating poliosis
CN103656587B (en) Medicine for treating facial neuritis and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
C06 Publication
SE01 Entry into force of request for substantive examination
C10 Entry into substantive examination
RJ01 Rejection of invention patent application after publication

Application publication date: 20170104

RJ01 Rejection of invention patent application after publication