CN105079366A - Enema preparation for treating severe acute organic phosphorus pesticide poisoning and preparation method thereof - Google Patents

Abstract

The invention discloses an enema preparation for treating severe acute organic phosphorus pesticide poisoning. The enema preparation is prepared from the following main raw materials in weight proportion: 10-30 parts of annual fleabane herb, 10-30 parts of common goldenrod herb, 20-40 parts of water chestnut, 20-40 parts of typhonium giganteum, 10-30 parts of irkutsk anemone rhizome, 10-30 parts of rheum franzenbachii, 3-7 parts of rhizoma coptidis from Sichuan of China, 8-16 parts of astragalus membranaceus, 10-30 parts of lonicera japonica, 5-15 parts of liquorice, 1-3 parts of folium artemisiae argyi, 10-20 parts of mint and 200-400 parts of edible vinegar. The enema preparation disclosed by the invention can better play the effects of detoxifying and promoting diuresis, can be used for treating severe acute organic phosphorus pesticide poisoning and has the characteristics of being free of pain, easy to accept, obvious in curative effect and unlikely to cause allergy.

Description

A kind of enema agent and method for making for the treatment of Severe Acute Organophosphorus Pesticide Poisoning

Technical field

The present invention relates to traditional Chinese medicine field, particularly a kind of enema agent and preparation method thereof of Severe Acute Organophosphorus Pesticide Poisoning.

Background technology

Organophosphorus pesticide (OPS) is the insecticide that China uses extensively, consumption is maximum.Mainly comprise dichlorvos, parathion (1605), thimet (3911), demeton (1059), Rogor, metrifonate, Malathion (4049) etc.Acute organophosphorus pesticide poisoning (AOPP) refers to a series of injuries based on nervous system damage caused after organophosphorus pesticide enters human body in short-term in a large number, mainly comprise cholinergic excitatory or the crisis of patients with acute intoxication performance clinically, acute coronary insufficiency (IMS) thereafter and Delayed onset peripheral neuropathy (OPIDPN).The annual whole world has millions of people that AOPP occurs, and wherein about have 300,000 human mortalities, and great majority occurs in developing country.The main path that organophosphorus pesticide enters human body has three: per os enters---wrongly take or active oral (seeing light survivor); Enter through skin and mucosa---be more common in organophosphor when spraying insecticide hot day and fall on skin, due to skin perspiration and pore expansion, organophosphorus pesticide mostly is fat-soluble in addition, therefore easily enters in body by skin and mucosal absorption; Entering through respiratory tract---the organophosphor in air enters in body with breathing.Many morbidities in 10 minutes to 2 hours after oral poisonous substance.Occur poisoning, generally morbidity in a few hours to 6 day after contact organophosphorus pesticide is absorbed through skin.

The cause of disease: the acetylcholine esterase that organophosphorus poison enters after in body rapidly in body is combined; generate phosphorylated acetylcholine esterase; acetylcholine esterase is made to lose the function of hydrolyse acetylcholine; cholinergic neurotransmitter is caused to gather in a large number; act on cholinoceptor; produce serious nervous dysfunction, particularly respiratory dysfunction, thus affect vital movement.The M sample effect caused due to parasympathetic nervous excitement makes a large amount of glandular secretion of patients with respiratory tract, causes serious pulmonary edema, has increased the weight of anoxia, patient Ke Yin respiratory failure and hypoxia death.AOPP also can cause heart damage, even can cause sudden cardiac death.Its reason may be directly damage heart to cause toxic myocarditis, and anoxia, electrolyte disturbance, acidosis etc. can increase the weight of heart damage indirectly in addition, simultaneously during AOPP the sympathetic nerve of patient and parasympathetic functions disorderly, cause arrhythmia.In addition as excessive in dosage of atropine during treatment, cause Heart Rate too fast and blood supply insufficiency, heart oxygen consumption increases simultaneously, and cause myocardial ischemia to damage, the stability of electrocardio-activity is affected, therefore malignant arrhythmia easily occurs, and even dies suddenly.

Clinical manifestation: acute organophosphorus pesticide after entering human body often the state of an illness develop rapidly, there is following situation in patient: 1. excited and crisis (1) muscarinic signs and symptoms of cholinergic nerve: the smooth muscle spasm mainly caused by the excitement of parasympathetic nervous tip and glandular secretion increase very soon.Clinical manifestation is Nausea and vomiting, stomachache, hyperhidrosis, shed tears, watery nasal discharge, sialorrhea, diarrhoea, frequent micturition, gatism, bradycardia and contracted pupil, bronchospasm and secretions increase, cough, out of breath, there is pulmonary edema in severe patient.(2) nicotinic signs and symptoms: acetylcholine, in striped muscle neuromuscular junction excess accumulation and stimulation, makes face, eyelid, tongue, extremity and the vibration of whole body striped muscle generation muscle fiber, even whole-body muscle tonic spasm.Patient often has whole body tightly to restraint and constriction, muscular strength then occurs and goes down and paralyse.Severe patient can have paralysis of respiratory muscle, causes peripheral respiratory failure.In addition because sympathetic ganglion stimulates by acetylcholine, after its joint, sympathetic fiber tip release catecholamine makes vasoconstriction, causes blood pressure to increase, palpitating speed and arrhythmia.(3) central nervous system symptom: central nervous system has the symptoms such as dizziness, headache, tired, ataxia, dysphoria, delirium, tic and stupor after stimulating by acetylcholine.2. acute coronary insufficiency: acute coronary insufficiency (IMS) refer to organophosphorus poison discharge postpone, distribution or the reason such as under medication more in vivo, acetylcholine esterase is suppressed for a long time, accumulate in synaptic space, high concentration acetylcholine continues to stimulate nicotine receptor on postsynaptic membrane and makes it to lose quick, causes impulsion to be obstructed produced series of symptoms in neuromuscular junction transmission.General after acute poisoning after acute poisoning remission in 1 ~ 4 day, the clinical manifestation that it is feature that patient occurs suddenly with the muscle of respiratory muscle, a cranial nerve motion domination and limbs near-end muscle weakness.There is neck, upper limb and paralysis of respiratory muscle in patient., there is blepharoptosis, eye abduction obstacle and facial paralysis in the person that involves cranial nerve.Myasthenia can cause respiratory failure around, now needs Breathing Suppotion immediately, then easily causes death as do not intervened in time.3. organophosphor delayed neuropathy: the general no sequel of organophosphorus pesticide acute poisoning.Few patients 2 ~ 3 weeks after acute poisoning transference cure can Late-onset neuropathy, mainly involves acral, and the neurological symptom such as lower extremity paralysis, limb muscle atrophy can occur.Thinking that this pathological changes does not cause by acetylcholine esterase is suppressed at present, may be because organophosphorus pesticide suppresses neural target esterase, and make its aging caused by.4. other performances: can cause allergic dermatitis after the contact such as dichlorvos, metrifonate, parathion, demeton skin, and can occur vesicle and decortication, severe patient can occur that skin chemical is burnt, and affects prognosis.Organophosphorus pesticide instillation eye can cause conjunctival congestion and contracted pupil.

Clinically, the traditional Chinese medical science is particular about " overall conditioning, determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", and Chinese medicine has certain therapeutic efficiency to treatment Severe Acute Organophosphorus Pesticide Poisoning.In existing patent document, Authorization Notice No. CN101947282B(application number 201010502453.6) Chinese patent disclose a kind of Chinese medicine for the treatment of Severe Acute Organophosphorus Pesticide Poisoning, it is characterized in that it is made up of the component of the material medicine proportioning of following weight, Radix Et Rhizoma Rhei 10-15g, Radix Aucklandiae 10-12g, Aloe 12-18g, Flos Lonicerae 8-12g, Cortex Magnoliae Officinalis 8-12g.

Now have the medicine of this disease for the treatment of numerous and diverse on the market, but to there is treatment time long because of Western medicine preparation, side effect is large, easy repeatedly, effect is undesirable, more and more abandon by people; As the saying goes: " being medicine three points of poison ".Even if take Chinese herbal medicine, also can increase the weight of the burden of the internal organs such as stomach, liver, kidney, the medicine arriving affected area so real is limited, and curative effect is very micro-.

Summary of the invention

For the deficiencies in the prior art, an object of the present invention is to provide a kind of enema agent for the treatment of Severe Acute Organophosphorus Pesticide Poisoning, this enema agent utilizes ten multidigit Chinese herbal medicine to work in coordination, make use of the stronger sterilization of vinegar and osmosis well simultaneously, removing toxic substances can be played better, effect of diuresis; Can Severe Acute Organophosphorus Pesticide Poisoning be treated, there is no pain, easily acceptance, evident in efficacy, not easily irritated feature; The present invention effectively can not only treat Severe Acute Organophosphorus Pesticide Poisoning and have good curative effect to alimentary toxicosis, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost; There is therapeutic effect good, have no side effect, the advantage that treatment cost is low.

Another object of the present invention is just to provide the preparation method of above-mentioned enema agent.

Above-mentioned purpose of the present invention is achieved through the following technical solutions: a kind of enema agent for the treatment of Severe Acute Organophosphorus Pesticide Poisoning, takes off the primary raw material stating weight proportion and is prepared from: Herba Erigerontis Annui 10-30 part, Herba Solidaginis 10-30 part, Corm Eleocharitis 20-40 part, Herba Typhonii gigantei 20-40 part, Rhizoma Anemones Altaicae 10-30 part, Radix et Rhizoma Rhei Franzenbachii 10-30 part, Rhizoma Coptidis 3-7 part, Radix Astragali 8-16 part, Flos Lonicerae 10-30 part, Radix Glycyrrhizae 5-15 part, Folium Artemisiae Argyi 1-3 part, Herba Menthae 10-20 part, vinegar 200-400 part.

Treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Herba Erigerontis Annui 15-25 part, Herba Solidaginis 15-25 part, Corm Eleocharitis 25-35 part, Herba Typhonii gigantei 25-35 part, Rhizoma Anemones Altaicae 15-25 part, Radix et Rhizoma Rhei Franzenbachii 15-25 part, Rhizoma Coptidis 4-6 part, Radix Astragali 10-14 part, Flos Lonicerae 15-25 part, Radix Glycyrrhizae 8-13 part, Folium Artemisiae Argyi 1.5-2.5 part, Herba Menthae 13-18 part, vinegar 280-380 part.

Treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, better preferred scheme is: take off the primary raw material stating weight proportion and be prepared from: Herba Erigerontis Annui 20 parts, Herba Solidaginis 20 parts, Corm Eleocharitis 30 parts, Herba Typhonii gigantei 30 parts, Rhizoma Anemones Altaicae 20 parts, Radix et Rhizoma Rhei Franzenbachii 20 parts, Rhizoma Coptidis 5 parts, the Radix Astragali 12 parts, Flos Lonicerae 20 parts, 10 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 2 parts, Herba Menthae 15 parts, vinegar 330 parts.

The preparation method of above-mentioned arbitrary described enema agent, step is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, food steamer is placed on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, puts into the crude drug smashed to pieces, steam 5-10 minute, rice vinegar is sprayed on crude drug, mixes thoroughly with chopsticks, again steaming and decocting 2-6 minute, even with rice wine spray again, stewing 10-20 minute stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 3-7 minute, take out to cool and grind to form smalls to cross 120-160 mesh sieve stand-by;

(3) step (2) gained smalls is placed in transparent glass container, puts into vinegar, under dandle 10-30, seal with adhesive tape, under being placed in the environment of 1-5 DEG C, leaving standstill and namely obtain enema agent in 10-20 hour.

Above-mentioned preparation method, step (1) puts into the crude drug smashed to pieces, steams 6-9 minute (preferred, to put into the crude drug smashed to pieces, steam 8 minutes).

Above-mentioned preparation method, the consumption of step (1) first time rice vinegar is that the 0.4-0.8 of mixed material medicine is doubly (preferred, the consumption of rice vinegar is 0.5-0.7 times of mixed material medicine for the first time, is more preferably, and the consumption of rice vinegar is 0.6 times of mixed material medicine for the first time).

Above-mentioned preparation method, step (1) is mixed thoroughly with chopsticks, again steaming and decocting 3-5 minute, evener with rice wine spray, stewing 13-18 minute (preferred, mix thoroughly with chopsticks, again steaming and decocting 4 minutes, evener with rice wine spray, stewing 15 minutes).

Above-mentioned preparation method, step (2) bake 4-6 minute, take out cool grind to form smalls cross 130-150 mesh sieve stand-by (preferred, bake 5 minutes, take out to cool grind to form smalls to cross 140 mesh sieves stand-by).

Above-mentioned preparation method, under step (3) dandle 15-25 (preferred, dandle 20 times).

Above-mentioned preparation method, under step (3) is placed in the environment of 2-4 DEG C, leaves standstill 13-18 hour (preferred, under being placed in the environment of 3 DEG C, to leave standstill 15 hours).

The pharmacological effect of each crude drug is respectively:

Herba Erigerontis Annui: be the herb of Compositae Herba Erigerontis aceris platymiscium Herba Erigerontis Annui.Composition: herb is containing pyromeconic acid.Flower is containing pyrite constituents: Quercetin, apigenin-7-glucuronide, apigenin etc.The property of medicine: sweet, bitter, cold.Function cures mainly: removing toxic substances, and hemostasis, helps digestion, preventing the attack (or recurrence) of malaria.Cure mainly lymphadenitis, gingivitis, venom, hematuria, dyspepsia, gastroenteritis, malaria.

Herba Solidaginis: be herb or the root of Compositae Herba Solidaginis platymiscium Herba Solidaginis.Composition: aerial parts is containing saponin component: Herba Solidaginis glycosides, activities of Solidago virgaurea L saponin 3 that is 3, Solidago saponin, solidago canadesis saponin, huge Herba Solidaginis saponin, the triterpene glycosides etc. of Polygalacic acid.The property of medicine: pungent, bitter, cool.Function cures mainly: wind and heat dispersing, removing toxic substances and promoting subsidence of swelling.Cure mainly anemopyretic cold, laryngopharynx swelling and pain, cough due to lung-heat, jaundice, pyretic stranguria, carbuncle furuncle, venom, traumatic injury.

Corm Eleocharitis: another name Horse hoof, black taro, Di Li.Flavor efficacy: sweet, cold.Function heat clearing away, reduce phlegm, removing food stagnancy, change wart.Be applicable to that epidemic febrile disease is quenched one's thirst, jaundice, pyretic stranguria, mass in the abdomen, conjunctival congestion, laryngopharynx swelling and pain, wart etc.Prevention acute infectious disease, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, diuresis relieving constipation is eliminated the phlegm, help digestion de-swelling, conditioning hemorrhoid or dysentery is had blood in stool, woman uterine bleeding, lung-dryness syndrome due to deficiency of YIN, phlegm-heat cough, discomfort in the throat, mass in the abdomen are gathered, conjunctival congestion is hidden from view, auxiliary effect such as to bring down a fever.In addition, Corm Eleocharitis contains a kind of antiviral substance can suppress epidemic encephalitis, influenza virus, can be used for the propagation preventing epidemic encephalitis and influenza.

Herba Typhonii gigantei: another name Rhizoma Typhonium Gigantei (Rhizoma Typhonii), milk in vain attached, red male star, numb taro, the wild Rhizoma Pinelliae, Cor Gigeriae Galli are attached in vain.Flavor efficacy acrid, sweet, warm.Poisonous.Return stomach, Liver Channel.Function drying dampness to eliminate phlegm, timid wind relieving convulsion, removing toxic substances powder knot.Be applicable to the stagnant network of wind-phlegm, facial hemiparalysis, apoplexy abundant expectoration, aphasia hemiplegia, tetanus and headache due to cold-damp; External is used for sucutaneous nodule scrofula, venom.

Rhizoma Anemones Altaicae: be the rhizome of Ranunculaceae thimbleweed anemone altaica.Composition: rhizome fatty acids: Palmic acid, succinic acid, 5-hydroxylevulinic acid, hexadecanoic acid and 9,12-octadecadienoic acid, Anemonin etc.The property of medicine: pungent, temperature.GUIXIN, liver, spleen channel.Function cures mainly: waking up the patient from unconsciousness by dissipating phlegm, and expelling wind and removing dampness helps digestion and is amusing, removing toxic substances.Cure mainly calentura coma, epilepsy, deafness with qi stagnation, dreaminess is forgetful, rheumatic arthralgia, and gastral cavity uncomfortable in chest is swollen, carbuncle, scabies.

Radix et Rhizoma Rhei Franzenbachii: be root and the cervical region of Polygonaceae Rheum plant rheum rhabarbarum.Composition: rheum rhabarbarum root and rhizome is containing general anthraquinone 1.11%, and wherein with emodin, chrysophanol is the combined anthraquinone 1.05% of aglycon, and sequestered is 0.06%, also containing wine plant glycosides, and physcione, and containing a small amount of aloe-emodin.Also containing a large amount of tannin and rheum rhabarbarum polysaccharide.The property of medicine: bitter, cold.Return stomach, large intestine channel.Function cures mainly: removing toxic substances of purging heat, removing heat from blood clots absorbing.Cure mainly jaundice due to damp-heat, dysentery, amenorrhea is suffered from abdominal pain, and spits blood, epistaxis, traumatic injury stasis of blood pain, carbuncle furunculosis, aphthous stomatitis, burn and scald.

Rhizoma Coptidis: bitter in the mouth cold in nature, belongs to and controls the key medicine of damp-heat in middle-JIAO, control damp-heat in upper-JIAO with Radix Scutellariae, Cortex Phellodendri controls together with damp-heat in lower-JIAO, often claims " SANHUANG ".There is the function of dampness heat clearing away, eliminating fire and detoxication.

Herba Menthae: it is pungent cool property sweating antipyretic medicine, controls influenza, the disease such as headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.Herba Menthae is Chinese conventional Chinese medicine, and young tender stem point can make vegetable edible, and herb can be used as medicine again, and cure cold heating laryngalgia, and headache, conjunctival congestion with ophthalmalgia, myalgia, skin rubella is scratched where it itches, the diseases such as measles without adequate eruption, also effective to carbuncle, cellulitis, scabies, tinea, dermatitis rhus in addition.Herba Menthae contains menthol, and this material can fresh breath have the multiple property of medicine, can alleviate stomachache, gallbladder problem as spasm, also have antisepsis and sterilization, diuresis, reduces phlegm, stomach invigorating and the effect such as aid digestion.A large amount of edible Herba Menthae can cause insomnia, but low dose of eating conduces to sleep.

Folium Artemisiae Argyi: pungent, bitter, temperature.Gui Jing: return liver,spleen,kidney warp.Effect: warming the meridian for stopping bleeding, dispersing cold for relieving pain; External removing dampness to relieve itching.

Cure mainly: for spitting blood, epistaxis, metrorrhagia, menorrhagia, vaginal bleeding during pregnancy hematochezia, few abdomen cold type of pain, coldness and unbalance in meridians, cold womb is infertile; External treatment skin pruritus.Vinegar Chinese mugwort charcoal warming the meridian for stopping bleeding is hemorrhage for deficient cold type.

Radix Glycyrrhizae: Radix Glycyrrhizae (formal name used at school: GlycyrrhizauralensisFisch) is called: state is old, Herba Hedyotis cantonensis, Glycyrrhiza uralensis Fisch., sweet root.Pulse family, Glycyrrhiza perennial herb, root and root stock sturdy, be a kind of tonification Chinese herbal medicine.To the good a kind of medicine of human body, medicinal part is root and rhizome, and Medicinal Materials Characters root is cylindrical, long 25 ~ 100 centimetres, diameter 0.6 ~ 3.5 centimetre.Crust degree of tightness differs, the brown or taupe brown of surface red.Rhizome is cylindrical, and there is bud trace on surface, has marrow in the middle part of section.Feeble QI, taste is sweet and special.Function cures mainly heat-clearing and toxic substances removing, expelling phlegm for arresting cough, gastral cavity abdomen etc., and Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect throat and the tunica mucosa tracheae of inflammation.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.

Vinegar: vinegar digestible fat and sugar: suitably drink vinegar, not only can lose weight, and can also impel nutrient burning in vivo and improve heat utilization rate, promoting healthy; Vinegar can reduce the picked-up of salinity: eat salty people for love, might as well to add some points vinegar at dish crack, a little less salt of more vinegar; Vinegar can suppress and reduce the formation of lipid peroxide in human aging process, reduces senile plaque, slow down aging; Vinegar has diuresis, can prevent urine retention, constipation and various calculus disease; Vinegar can reduce blood pressure, vessel softening, reduces the accumulation of cholesterol and reduces glucose in urine content, preventing cardiovascular disease and diabetes; Vinegar contains the alkali earth metals such as abundant K, Na, Ca, Mg, in alkalescence after people's stomach, the acid-base balance of blood can be regulated, maintain the relative equilibrium of human internal environment, reduce the various diseases such as arteriosclerosis, hyperlipidemia, hyperglycemia and the metabolic arthritis brought out because of body fluid acidify.

A kind of enema agent for the treatment of Severe Acute Organophosphorus Pesticide Poisoning of the present invention meets the theory of the traditional Chinese medical science about treatment Severe Acute Organophosphorus Pesticide Poisoning, for above-mentioned defect in the Chinese medicine process for the treatment of Severe Acute Organophosphorus Pesticide Poisoning, this product is on the basis of summing up forefathers' experience, go through clinical research for many years, adopt pure natural draft Chinese medicine unique formula and technique to refine to form, this product includes abundant plant biological active component, can affected part be directly acted on, human body skin easily accepts, evident in efficacy, not easily irritated feature.

Detailed description of the invention

Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.

embodiment 1:treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, be prepared from the primary raw material of following weight proportion: Herba Erigerontis Annui 10 parts, Herba Solidaginis 10 parts, Corm Eleocharitis 20 parts, Herba Typhonii gigantei 20 parts, Rhizoma Anemones Altaicae 10 parts, Radix et Rhizoma Rhei Franzenbachii 10 parts, Rhizoma Coptidis 3 parts, the Radix Astragali 8 parts, Flos Lonicerae 10 parts, 5 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 12 parts, Herba Menthae 10 parts, vinegar 200 parts.

The preparation method of the enema agent of above-mentioned treatment Severe Acute Organophosphorus Pesticide Poisoning is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, be placed on by food steamer on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, put into the crude drug smashed to pieces, steam 5 minutes, be sprayed at by rice vinegar on crude drug, the consumption of rice vinegar is 0.4 times of mixed material medicine, mix thoroughly with chopsticks, steaming and decocting 2 minutes again, evener with rice wine spray, stewing 10 minutes are stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 3 minutes, take out to cool and grind to form smalls to cross 120 mesh sieves stand-by;

(3) be placed in transparent glass container by step (2) gained smalls, put into vinegar, dandle 10 times, seals with adhesive tape, and under being placed in the environment of 1 DEG C, leaving standstill and namely obtains enema agent in 10 hours.

embodiment 2:treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, be prepared from the primary raw material of following weight proportion: Herba Erigerontis Annui 30 parts, Herba Solidaginis 30 parts, Corm Eleocharitis 40 parts, Herba Typhonii gigantei 40 parts, Rhizoma Anemones Altaicae 30 parts, Radix et Rhizoma Rhei Franzenbachii 30 parts, Rhizoma Coptidis 7 parts, the Radix Astragali 16 parts, Flos Lonicerae 30 parts, 15 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 24 parts, Herba Menthae 20 parts, vinegar 400 parts.

The preparation method of the enema agent of above-mentioned treatment Severe Acute Organophosphorus Pesticide Poisoning is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, be placed on by food steamer on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, put into the crude drug smashed to pieces, steam 10 minutes, be sprayed at by rice vinegar on crude drug, the consumption of rice vinegar is 0.8 times of mixed material medicine, mix thoroughly with chopsticks, steaming and decocting 6 minutes again, evener with rice wine spray, stewing 20 minutes are stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 7 minutes, take out to cool and grind to form smalls to cross 160 mesh sieves stand-by;

(3) be placed in transparent glass container by step (2) gained smalls, put into vinegar, dandle 30 times, seals with adhesive tape, and under being placed in the environment of 5 DEG C, leaving standstill and namely obtains enema agent in 20 hours.

embodiment 3:treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, be prepared from the primary raw material of following weight proportion: Herba Erigerontis Annui 15 parts, Herba Solidaginis 15 parts, Corm Eleocharitis 25 parts, Herba Typhonii gigantei 25 parts, Rhizoma Anemones Altaicae 15 parts, Radix et Rhizoma Rhei Franzenbachii 15 parts, Rhizoma Coptidis 4 parts, the Radix Astragali 10 parts, Flos Lonicerae 15 parts, 8 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 14 parts, Herba Menthae 13 parts, vinegar 280 parts.

The preparation method of the enema agent of above-mentioned treatment Severe Acute Organophosphorus Pesticide Poisoning is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, be placed on by food steamer on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, put into the crude drug smashed to pieces, steam 6 minutes, be sprayed at by rice vinegar on crude drug, the consumption of rice vinegar is 0.5 times of mixed material medicine, mix thoroughly with chopsticks, steaming and decocting 3 minutes again, evener with rice wine spray, stewing 13 minutes are stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 4 minutes, take out to cool and grind to form smalls to cross 130 mesh sieves stand-by;

(3) be placed in transparent glass container by step (2) gained smalls, put into vinegar, dandle 15 times, seals with adhesive tape, and under being placed in the environment of 2 DEG C, leaving standstill and namely obtains enema agent in 13 hours.

embodiment 4:treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, be prepared from the primary raw material of following weight proportion: Herba Erigerontis Annui 25 parts, Herba Solidaginis 25 parts, Corm Eleocharitis 35 parts, Herba Typhonii gigantei 35 parts, Rhizoma Anemones Altaicae 25 parts, Radix et Rhizoma Rhei Franzenbachii 25 parts, Rhizoma Coptidis 6 parts, the Radix Astragali 14 parts, Flos Lonicerae 25 parts, 13 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 22 parts, Herba Menthae 18 parts, vinegar 380 parts.

The preparation method of the enema agent of above-mentioned treatment Severe Acute Organophosphorus Pesticide Poisoning is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, be placed on by food steamer on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, put into the crude drug smashed to pieces, steam 9 minutes, be sprayed at by rice vinegar on crude drug, the consumption of rice vinegar is 0.7 times of mixed material medicine, mix thoroughly with chopsticks, steaming and decocting 5 minutes again, evener with rice wine spray, stewing 18 minutes are stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 6 minutes, take out to cool and grind to form smalls to cross 150 mesh sieves stand-by;

(3) be placed in transparent glass container by step (2) gained smalls, put into vinegar, dandle 25 times, seals with adhesive tape, and under being placed in the environment of 4 DEG C, leaving standstill and namely obtains enema agent in 18 hours.

embodiment 5:treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, be prepared from the primary raw material of following weight proportion: Herba Erigerontis Annui 20 parts, Herba Solidaginis 20 parts, Corm Eleocharitis 30 parts, Herba Typhonii gigantei 30 parts, Rhizoma Anemones Altaicae 20 parts, Radix et Rhizoma Rhei Franzenbachii 20 parts, Rhizoma Coptidis 5 parts, the Radix Astragali 12 parts, Flos Lonicerae 20 parts, 10 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 18 parts, Herba Menthae 15 parts, vinegar 330 parts.

The preparation method of the enema agent of above-mentioned treatment Severe Acute Organophosphorus Pesticide Poisoning is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, be placed on by food steamer on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, put into the crude drug smashed to pieces, steam 8 minutes, be sprayed at by rice vinegar on crude drug, the consumption of rice vinegar is 0.6 times of mixed material medicine, mix thoroughly with chopsticks, steaming and decocting 4 minutes again, evener with rice wine spray, stewing 15 minutes are stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 5 minutes, take out to cool and grind to form smalls to cross 140 mesh sieves stand-by;

(3) be placed in transparent glass container by step (2) gained smalls, put into vinegar, dandle 20 times, seals with adhesive tape, and under being placed in the environment of 3 DEG C, leaving standstill and namely obtains enema agent in 15 hours.

experimental example 1:in order to verify the drug effect of embodiment 5 gained enema agent, we have also carried out great many of experiments, have chosen 200 patients from 5 hospitals, wherein, the medicine of embodiment 5 products obtained therefrom and this disease of other treatment is utilized to carry out contrast test, we divide into two groups patient in an experiment: matched group and experimental group, matched group uses medicine, the oral medicine etc. of gastric lavage, and every natural gift are observed for three times and record the situation of patient simultaneously, comprise self-induction symptom and the emotion situations such as whether poisoning degree, mind clear-headed.

Using method: adopt enema of the present invention, carry out coloclysis, severe patient one twice-daily and coordinate other drug to carry out gastric lavage, patients with mild once-a-day.

Criterion: cure: after using enema agent of the present invention, malaise symptoms disappears, effectively: after using enema agent of the present invention, malaise symptoms alleviates, invalid: after using enema agent of the present invention, malaise symptoms is unchanged.

Specific experiment result is as following table:

Table 2:

efficacy analysis:experiment shows to use its raising more than 10% evident in efficacy compared with matched group of the administration group of this medicine, and cure rate significantly improves, and real to solve patient ailing, and can solve great pain and torment that this disease of Severe Acute Organophosphorus Pesticide Poisoning brings to patient.In sum, a kind of enema agent Be very effective for the treatment of Severe Acute Organophosphorus Pesticide Poisoning of the present invention, Most patients is clearly better in medication symptom on the same day, sense of discomfort disappears to some extent, comparatively severe patient after medication two weeks symptom also can be improved significantly, this medicine can reach analgesic effect very soon, effective percentage 98%, if can adhere to using according to using method, substantially thoroughly focus can be removed.

Claims (10)

1. treat an enema agent for Severe Acute Organophosphorus Pesticide Poisoning, it is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Herba Erigerontis Annui 10-30 part, Herba Solidaginis 10-30 part, Corm Eleocharitis 20-40 part, Herba Typhonii gigantei 20-40 part, Rhizoma Anemones Altaicae 10-30 part, Radix et Rhizoma Rhei Franzenbachii 10-30 part, Rhizoma Coptidis 3-7 part, Radix Astragali 8-16 part, Flos Lonicerae 10-30 part, Radix Glycyrrhizae 5-15 part, Folium Artemisiae Argyi 1-3 part, Herba Menthae 10-20 part, vinegar 200-400 part.

2. the enema agent for the treatment of Severe Acute Organophosphorus Pesticide Poisoning according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Herba Erigerontis Annui 15-25 part, Herba Solidaginis 15-25 part, Corm Eleocharitis 25-35 part, Herba Typhonii gigantei 25-35 part, Rhizoma Anemones Altaicae 15-25 part, Radix et Rhizoma Rhei Franzenbachii 15-25 part, Rhizoma Coptidis 4-6 part, Radix Astragali 10-14 part, Flos Lonicerae 15-25 part, Radix Glycyrrhizae 8-13 part, Folium Artemisiae Argyi 1.5-2.5 part, Herba Menthae 13-18 part, vinegar 280-380 part.

3. the enema agent for the treatment of Severe Acute Organophosphorus Pesticide Poisoning according to claim 1, is characterized in that: take off the primary raw material stating weight proportion and be prepared from: Herba Erigerontis Annui 20 parts, Herba Solidaginis 20 parts, Corm Eleocharitis 30 parts, Herba Typhonii gigantei 30 parts, Rhizoma Anemones Altaicae 20 parts, Radix et Rhizoma Rhei Franzenbachii 20 parts, Rhizoma Coptidis 5 parts, the Radix Astragali 12 parts, Flos Lonicerae 20 parts, 10 parts, Radix Glycyrrhizae, Folium Artemisiae Argyi 2 parts, Herba Menthae 15 parts, vinegar 330 parts.

4. the preparation method of the enema agent of the treatment Severe Acute Organophosphorus Pesticide Poisoning according to any one of claim 1-3, is characterized in that: step is as follows:

(1) get Herba Erigerontis Annui, Herba Solidaginis, Corm Eleocharitis, Herba Typhonii gigantei, Rhizoma Anemones Altaicae, Radix et Rhizoma Rhei Franzenbachii, Rhizoma Coptidis, the Radix Astragali, Flos Lonicerae, Radix Glycyrrhizae, Folium Artemisiae Argyi and Herba Menthae to clean up, smash to pieces, pot is cleaned, clear water is added in pot, boil rear truce, food steamer is placed on pot, spread fresh Folium Nelumbinis, cover lid steams out fragrance, puts into the crude drug smashed to pieces, steam 5-10 minute, rice vinegar is sprayed on crude drug, mixes thoroughly with chopsticks, again steaming and decocting 2-6 minute, even with rice wine spray again, stewing 10-20 minute stand-by;

(2) step (1) gained crude drug is taken out be laid in baking box, bake 3-7 minute, take out to cool and grind to form smalls to cross 120-160 mesh sieve stand-by;

(3) step (2) gained smalls is placed in transparent glass container, puts into vinegar, under dandle 10-30, seal with adhesive tape, under being placed in the environment of 1-5 DEG C, leaving standstill and namely obtain enema agent in 10-20 hour.

5. preparation method according to claim 4, is characterized in that: step (1) puts into the crude drug smashed to pieces, steams 6-9 minute (preferred, to put into the crude drug smashed to pieces, steam 8 minutes).

6. preparation method according to claim 4, it is characterized in that: the consumption of step (1) first time rice vinegar is that the 0.4-0.8 of mixed material medicine is doubly (preferred, the consumption of rice vinegar is 0.5-0.7 times of mixed material medicine for the first time, more preferably good, the consumption of rice vinegar is 0.6 times of mixed material medicine for the first time).

7. preparation method according to claim 4, is characterized in that: step (1) is mixed thoroughly with chopsticks, again steaming and decocting 3-5 minute, even with rice wine spray again, stewing 13-18 minute (preferred, mix thoroughly with chopsticks, steaming and decocting 4 minutes again, evener with rice wine spray, stewing 15 minutes).

8. preparation method according to claim 4, is characterized in that: step (2) bake 4-6 minute, take out cool grind to form smalls cross 130-150 mesh sieve stand-by (preferred, bake 5 minutes, take out to cool grind to form smalls to cross 140 mesh sieves stand-by).

9. preparation method according to claim 4, is characterized in that: under step (3) dandle 15-25 (preferred, dandle 20 times).

10. preparation method according to claim 4, is characterized in that: under step (3) is placed in the environment of 2-4 DEG C, leaves standstill 13-18 hour (preferred, under being placed in the environment of 3 DEG C, to leave standstill 15 hours).