CN105056137A - Traditional Chinese medicine composition for treating toxic and diffuse goiter - Google Patents

Abstract

The invention belongs to the technical field of medicine, and particularly relates to a traditional Chinese medicine composition for treating toxic and diffuse goiter. The traditional Chinese medicine is composed of, by weight, 8-16 parts of distilled liquid of fleshfingered citron, 8-16 parts of citron fruit, 8-16 parts of flos rosae rugosae, 8-16 parts of algae, 8-16 parts of carageen, 8-16 parts of edible seaweed, 6-14 parts of Chinese roses, 6-14 parts of saffron, 6-14 parts of radix curcumae, 8-16 parts of rhizoma atractylodis macrocephalae, 8-16 parts of radix pseudostellariae and 4-8 parts of licorice roots. According to the traditional Chinese medicine composition for treating the toxic and diffuse goiter, by means of the combination of the medicine, the efficacy of removing stagnation, dissipating phlegm, promoting blood circulation to remove blood stasis and softening hardness to dissipate stagnation is achieved, basic pathogenesis of Qi depression and phlegm stagnation type Graves diseases is closely focused, obvious advantages in improvements of aspects such as clinical symptoms, signs and the thyroid function of a patient are achieved, the curative effect is definite, and adverse reactions are few.

Description

A kind of Chinese medicine composition for the treatment of graves

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of graves.

Background technology

Graves (Graves is sick) is the modal type of hyperthyroidism.It causes thyroid hormone secretion too much by many reasons, causes to increase with system stimulant such as nerve, circulation, digestion to permit into the clinical syndrome for main manifestations with metabolism.The clinical manifestation of Graves disease is mainly typical hypermetabolism syndrome, diffuse goiter in various degree and other Analysis of multi-organic functional damages.Its outstanding feature is that difference between male is obvious, and namely women's sickness rate is about 5 ~ 10 times of male patient.

In recent years, along with the development of society, industrial and agricultural waste discharge increase and work, the aggravation of social pressure, its sickness rate is ascendant trend year by year.Because this sick classical symptom is throat enlargement, often affect the attractive in appearance of patient, the course of disease is long in addition, is easy to recurrence, brings great harm to patient's physical and mental health, for this reason, accomplishes that early diagnosis, in time intervention are very important.

Current western medical treatment main method comprises: Anti-thyroid Medicine, radiosiotope and operative treatment etc.Anti-thyroid Medicine applied range, but the course for the treatment of is longer, and easily recurring, also can there is the curative effect of the side effect such as agranulocytosis, liver function injury and this disease of operative treatment certainly in small number of patients, but long term complication is more, and easily there is hypothyroidism.But Chinese Traditional Medicine treatment not only long and rich experience, its base oneself upon entirety, the dialectical unique advantage treated especially modern medicine be difficult to the part that matches in excellence or beauty.Therefore, the Chinese medicine finding treatment graves is needed.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of graves.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine composition for graves, be made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 8-16 part, Fructus Citri 8-16 part, Flos Rosae Rugosae 8-16 part, Nemacystus decipiens (Sur.) Kuck 8-16 part, Pelvetia siliquosa Tseng et C. F. Chang 8-16 part, Eucheuma gelatinosum 8-16 part, Flos Rosae Chinensis 6-14 part, Stigma Croci 6-14 part, Radix Curcumae 6-14 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Radix Pseudostellariae 8-16 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of above-mentioned treatment graves, is made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 10-14 part, Fructus Citri 10-14 part, Flos Rosae Rugosae 10-14 part, Nemacystus decipiens (Sur.) Kuck 10-14 part, Pelvetia siliquosa Tseng et C. F. Chang 10-14 part, Eucheuma gelatinosum 10-14 part, Flos Rosae Chinensis 8-12 part, Stigma Croci 8-12 part, Radix Curcumae 8-12 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Pseudostellariae 10-14 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine composition of above-mentioned treatment graves, is made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 12 parts, Fructus Citri 12 parts, Flos Rosae Rugosae 12 parts, Nemacystus decipiens (Sur.) Kuck 12 parts, Pelvetia siliquosa Tseng et C. F. Chang 12 parts, Eucheuma gelatinosum 12 parts, Flos Rosae Chinensis 10 parts, Stigma Croci 10 parts, Radix Curcumae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Pseudostellariae 12 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of graves.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Liquor Fructus Citri sarcodactylis Distillata is rutaceae Fructus Citri Sarcodactylis CitrusmedicaL.var.sarcodactylis(Noot.) distillate of the fruit of Swingle.Taste is micro-pungent; Light; Property is put down.Return lung; Liver; Stomach; Kidney channel.Function promoting QI circulation for relieving depression.Main chest and diaphragm is gloomy not to relax

Nemacystus decipiens (Sur.) Kuck calls smooth dish, is Nemacystus decipiens (Sur.) Kuck section plant Nemacystus decipiens (Sur.) Kuck Nemacystusdecipiens (Sur.) Kuck. [MesogloeadecipiensSur.; Cladosiphondecipiens (Sur.) Okam.] frond.Nature and flavor are salty; Cold; Nontoxic.Return liver; Lung meridian.Function eliminating phlegm and softening indurated mass; Inducing diuresis to remove edema.Main goiter; Goiter; Laryngitis; Bronchitis.

Pelvetia siliquosa Tseng et C. F. Chang another name Cornu Cervi rod, Cornu Cervi bean are the frond of Fucus Vesiculosus section plant Pelvetia siliquosa Tseng et C. F. Chang PelvetiasiliquosaTsengetC.F.Chang [PelvetiaminorNoda].Nature and flavor are salty; Great Cold.Function removing heat-phlegm; Hard masses softening and resolving.Main consumptive fever hectic fever due to YIN-deficiency; Phlegm-heat cough; Pulmonary tuberculosis; Goiter; Scrofula.

Eucheuma gelatinosum another name onyx, Eucheuma gelatinosum, Parmelia saxatilis Ach., Ottelia acuminata (Gagnep.) Dandy, Herba Pileae Scriptae are the frond of Hong Ling dish section plant Eucheuma gelatinosum Eucheumagelatinae (Esp.) J.Ag..Sweet in the mouth; Salty; Cold in nature; Nontoxic.Return lung; Liver; Large intestine channel.Function removing heat from the lung and dissipating phlegm; Hard masses softening and resolving; Removing toxic substances.Main phlegm-heat cough; Gall subcutaneous nodule; Swelling and pain of hemorrhoid or hematochezia; Enteritis.

Namely Stigma Croci another name spreads method, originates as the top of irides Stigma Croci style and stigma.Sweet in the mouth, property is put down.Enter the heart, Liver Channel.Function blood circulation promoting and blood stasis dispelling, dispersing stagnation and relieving accumulation of pathogens.Control troubled thoughts pent-up, chest and diaphragm painful abdominal mass is vexed, and spit blood, typhoid fever is gone mad, and frightened fear in a trance, women's amenorrhea, postnatal blood stasis is suffered from abdominal pain, tumbling and swelling.

Other Chinese medicine related in Chinese medicine composition prescription of the present invention all records in Chinese Pharmacopoeia 2010 editions.

Thyroid disease belongs to the category such as traditional Chinese medical science “ Gall disease, " melancholia "; Its cause of disease, pathogenesis relative complex, stagnation of QI stagnation of phlegm blood stasis stops up the key point that knot throat is then its morbidity.Turbid and the blood stasis of expectorant is the main pathological product of this disease, and stagnation of QI phlegm retention is its different TCM syndrome types, and treatment should with activating QI to alleviate the depression, eliminating phlegm and softening indurated mass, blood circulation promoting and blood stasis dispelling for method.

The prescription mechanism of the Chinese medicine composition for the treatment of graves of the present invention is as follows:

Monarch drug: Liquor Fructus Citri sarcodactylis Distillata, Fructus Citri, Flos Rosae Rugosae merit are with promoting QI circulation for relieving depression.

Ministerial drug: Nemacystus decipiens (Sur.) Kuck, Pelvetia siliquosa Tseng et C. F. Chang, Eucheuma gelatinosum merit are with eliminating phlegm and softening indurated mass eliminating stagnation; Flos Rosae Chinensis, Stigma Croci, Radix Curcumae merit are with blood circulation promoting and blood stasis dispelling, and three medicines have effect of resolving depression relieving accumulation of pathogens concurrently simultaneously.

Adjuvant drug: the Rhizoma Atractylodis Macrocephalae, Radix Pseudostellariae merit are with invigorating the spleen and benefiting QI, and temper is good for, then qi-blood-body fluid runs officials, and phlegm-damp is from going, and middle burnt mechanism of qi is smooth and easy, then the stagnation of QI is explained by oneself.

Make medicine: Radix Glycyrrhizae merit is with coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, all medicines share the effect of playing dissipating depression and eliminating phlegm, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving altogether, the basic pathogenesis of the stagnation of QI that links closely expectorant junction type Graves disease, improve in patient clinical symptom, sign and thyroid function etc. with the obvious advantage, determined curative effect, untoward reaction is few.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine composition for graves, each crude drug weight proportion is as follows:

Liquor Fructus Citri sarcodactylis Distillata 12g, Fructus Citri 12g, Flos Rosae Rugosae 12g, Nemacystus decipiens (Sur.) Kuck 12g, Pelvetia siliquosa Tseng et C. F. Chang 12g, Eucheuma gelatinosum 12g, Flos Rosae Chinensis 10g, Stigma Croci 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Pseudostellariae 12g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine composition for graves, each crude drug weight proportion is as follows:

Liquor Fructus Citri sarcodactylis Distillata 10g, Fructus Citri 10g, Flos Rosae Rugosae 10g, Nemacystus decipiens (Sur.) Kuck 10g, Pelvetia siliquosa Tseng et C. F. Chang 10g, Eucheuma gelatinosum 10g, Flos Rosae Chinensis 8g, Stigma Croci 8g, Radix Curcumae 8g, Rhizoma Atractylodis Macrocephalae 10g, Radix Pseudostellariae 10g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine composition for graves, each crude drug weight proportion is as follows:

Liquor Fructus Citri sarcodactylis Distillata 14g, Fructus Citri 14g, Flos Rosae Rugosae 14g, Nemacystus decipiens (Sur.) Kuck 14g, Pelvetia siliquosa Tseng et C. F. Chang 14g, Eucheuma gelatinosum 14g, Flos Rosae Chinensis 12g, Stigma Croci 12g, Radix Curcumae 12g, Rhizoma Atractylodis Macrocephalae 14g, Radix Pseudostellariae 14g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine composition for graves, each crude drug weight proportion is as follows:

Liquor Fructus Citri sarcodactylis Distillata 8g, Fructus Citri 8g, Flos Rosae Rugosae 8g, Nemacystus decipiens (Sur.) Kuck 8g, Pelvetia siliquosa Tseng et C. F. Chang 8g, Eucheuma gelatinosum 8g, Flos Rosae Chinensis 6g, Stigma Croci 6g, Radix Curcumae 6g, Rhizoma Atractylodis Macrocephalae 8g, Radix Pseudostellariae 8g, Radix Glycyrrhizae 4g.

Embodiment 5

Treat a Chinese medicine composition for graves, each crude drug weight proportion is as follows:

Liquor Fructus Citri sarcodactylis Distillata 16g, Fructus Citri 16g, Flos Rosae Rugosae 16g, Nemacystus decipiens (Sur.) Kuck 16g, Pelvetia siliquosa Tseng et C. F. Chang 16g, Eucheuma gelatinosum 16g, Flos Rosae Chinensis 14g, Stigma Croci 14g, Radix Curcumae 14g, Rhizoma Atractylodis Macrocephalae 16g, Radix Pseudostellariae 16g, Radix Glycyrrhizae 8g.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose 150 routine stagnation of QI expectorant junction type Graves patients.

1.2 diagnostic criteria

Western medicine diagnose standard: with reference to " guideline of clinical investigations of new Chinese medicine treatment hyperthyroidism ".

Main clinical manifestation:

1. symptom: classical symptom has nervous, anxiety, emotional, and To Be Protected from Heat, hyperhidrosis, poke, appetite permit into, lose weight, brothers' hygropyrexia, fine tremor, small number of patients shows as expophthalmos.

2. sign: thyroid: thyroid anthorisma, quality is softer, and without tenderness, local palpation can feel fine tremor, auscultation audible and vascular murmur; Ocular signs: expophthalmos (bilateral or one-sided), though malignant exophthalmos is rare, is in a bad way; Nervous system: emotional, emotional instability, hand tremor test is positive; Cardiovascular system: increased heart rate, hear sounds strengthens, and blood pressure pulse pressure difference increases, visible arrhythmia; Digestive system: polyorexia, stool matter is rare, number of times showed increased, weight loss.

Physico-chemical examination

1. hormone determination: TT3, TT4, FT3, FT4 measured value raises, TSH measured value reduction or normal; 2. Thyroid Intaking 131I functional examination: iodine taking rate increases, the absorbance of 3 hours is faster, 3 hours >25%; Or 24 hours >45%; There is peak reach; 3. color Doppler ultrasonography: thyroid diffusivity hypertrophy, blood flow enriches, without obvious tuberosity; 4. basal metabolic rate measuring: basal metabolic rate=(pulse+pulse pressure)-111, increases during hyperthyroidism.

Differential diagnosis in tcm standard: stagnation of QI phlegm retention Standards of Chinese Medical Syndrome Differentiation is with reference to " disease of tcm conventional treatment ", " tcm internal medicine commonly encountered diseases practice guidelines " and " Chinese Internal Medicine ".

Primary symptom: throat enlargement, can touch tuberosity or lump, matter is soft, the activity of pressing, and moves up and down with swallowing, and cardiopalmus, hyperhidrosis, bulimia, emaciated physique, hands quiver;

Secondary disease: hypochondriac pain uncomfortable in chest, irritable, sighing frequently, changes, fatigue and weakness with the fluctuation of feelings will;

Tongue arteries and veins: red tongue or have ecchymosis, speckle, thin white fur of tongue or greasy in vain, stringy and rolling pulse.

Possess that in primary symptom 3 are double to see in time disease 2 or more, dialectical with reference to tongue arteries and veins is assertive evidence.

Tcm symptom, sign standards of grading, formulate with reference to " guideline of clinical investigations of new Chinese medicine treatment hyperthyroidism " related content.

1.3 thyromegaly calibration standards

Normal: inspection, palpation thyroid are all little, 0 point.

I degree: inspection thyroid is little, and matter is soft, and edge is no more than sternocleidomastoid leading edge, 1 point.

II degree: can see thyromegaly, in matter, edge is no more than sternocleidomastoid trailing edge, 2 points.

III degree: obviously, matter is tough, and its scope exceedes sternocleidomastoid trailing edge, 3 points for inspection, palpation thyromegaly.

1.4 include in and exclusion standard

Inclusive criteria

(1) age was at 18 ~ 60 years old.

(2) the sick Western medicine diagnose of above-mentioned Graves and traditional Chinese medical science stagnation of QI phlegm retention standard is met.

(3) severity Scaling belongs to light, moderate.

(4) darling renal function is normal, without other systemic disease and protopathy.

(5) compliance is good, voluntary partner treatment.

Exclusion standard

(1) age is at under-18s, more than 60 years old person.

(2) doctor trained in Western medicine and tcm diagnosis standard person is not met.

(3) gestation or women breast-feeding their children.

(4) hyperthyroidism crisis, various thyroiditis.Severity Scaling belongs to severe, and thyroid obviously oppresses peripheral organs person.

(5) primary diseases such as the heart, Liver and kidney function obstacle and hemopoietic system are merged.

(6) to antithyroid drug allergy sufferers.

(7) compliance is poor, can not regular further consultation person.

1.5 Therapeutic Method

Give Chinese medicine composition of the present invention, prescription: Liquor Fructus Citri sarcodactylis Distillata 12g, Fructus Citri 12g, Flos Rosae Rugosae 12g, Nemacystus decipiens (Sur.) Kuck 12g, Pelvetia siliquosa Tseng et C. F. Chang 12g, Eucheuma gelatinosum 12g, Flos Rosae Chinensis 10g, Stigma Croci 10g, Radix Curcumae 10g, Rhizoma Atractylodis Macrocephalae 12g, Radix Pseudostellariae 12g, Radix Glycyrrhizae 6g, be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.

1.6 observation index

General health check-up project: before and after the general health check-up project treatment such as heart rate, breathing, pulse, blood pressure, body weight, height and every month Check once; After routine urinalysis, just conventional and Electrocardioscopy give and treat front and treatment, each inspection once.

Observation of curative effect

1. cardinal symptom (nervous, anxiety, emotional, To Be Protected from Heat, hyperhidrosis, and bulimia is become thin), monthly records once;

2. main physical signs (thyromegaly, region thyreoidea trembles and vascular murmur for body weight change, pulse frequency), monthly records once;

3. thyroid function (TSH, FT3, FT4 detect), before treatment, March monthly checks once; Rear March examines Check every other month;

4. thyroid color ultrasound (observing thyromegaly degree and blood circumstance), monthly checks once.

1.7 curative effect determinate standards:

Doctor trained in Western medicine curative effect determinate standard: with reference to " new Chinese medicine treatment thyroid function permits the guideline of clinical investigations into disease "

1. clinical recovery: clinical symptom disappearance, pulse frequency is normal, and body weight increases, and region thyreoidea trembles and vessel of thyroid noise disappears, and every lab testing project recovers normal, thyromegaly and or expophthalmos levy and alleviate;

2. effective: main clinic symptoms disappears substantially, pulse frequency is normal, and body weight increases, and region thyreoidea vascular murmur, both hands carefully quiver and to levy and tremble disappearance, and every lab testing project recovers normal substantially, and thyromegaly and expophthalmos are levied and alleviated;

3. effective: symptom takes a turn for the better, body weight increases, and decreased heart rate, goiter is reduced, and region thyreoidea vascular murmur alleviates, and every lab testing project is roughly normal.

4. invalid: after treatment, clinical symptoms, sign, laboratory inspection Check are all not improved.

1.8 statistical method

Using statistics software carries out analytic statistics analysis.Enumeration data adopts X2 inspection, and measurement data adopts t inspection, with P<0.05, ranked data Bian rank test, represents that difference has statistical significance.

2. result

TCM syndrome integral contrast before and after 2.1 treatments

After treatment, TCM syndrome integration (6.65 ± 1.32) obviously reduces (35.72 ± 4.85) before comparatively treating, and difference has statistical significance (P<0.05).

2.2 clinical efficacy

In 150 routine patients, recovery from illness 122 example, effective 18 examples, effective 9 examples, invalid 1 example, cure rate 81.3%, total obvious effective rate 93.3%, total effective rate 99.3%.

TSH, FT3, FT4 change before and after 2.3 treatments

After treatment, FT3, FT4 level obviously reduces before comparatively treating, and after treatment, TSH level obviously raises before comparatively treating, and difference has statistical significance (P<0.05), in table 1.

Front and back TSH, FT3, FT4 change treated by table 1

Time	Number of cases	FT3（pmol/L）	FT4（pmol/L）	TSH（uIU/L）
					Before treatment	150	19.23±4.22	63.25±14.37	0.052±0.013
After treatment	150	4.24±0.76	7.54±1.27	3.28±0.64

Thyromegaly integral contrast before and after 2.4 treatments

After treatment, thyromegaly integration (1.14 ± 0.57) obviously reduces (2.43 ± 0.86) before comparatively treating, and difference has statistical significance (P<0.05).

2.3 safety observations

Before and after treatment, routine blood test, electrocardiogram, liver function, kidney function test have no significant change, and drug safety is good.

Claims (3)

1. treat a Chinese medicine composition for graves, be made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 8-16 part, Fructus Citri 8-16 part, Flos Rosae Rugosae 8-16 part, Nemacystus decipiens (Sur.) Kuck 8-16 part, Pelvetia siliquosa Tseng et C. F. Chang 8-16 part, Eucheuma gelatinosum 8-16 part, Flos Rosae Chinensis 6-14 part, Stigma Croci 6-14 part, Radix Curcumae 6-14 part, Rhizoma Atractylodis Macrocephalae 8-16 part, Radix Pseudostellariae 8-16 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition for the treatment of graves according to claim 1, is characterized in that, is made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 10-14 part, Fructus Citri 10-14 part, Flos Rosae Rugosae 10-14 part, Nemacystus decipiens (Sur.) Kuck 10-14 part, Pelvetia siliquosa Tseng et C. F. Chang 10-14 part, Eucheuma gelatinosum 10-14 part, Flos Rosae Chinensis 8-12 part, Stigma Croci 8-12 part, Radix Curcumae 8-12 part, Rhizoma Atractylodis Macrocephalae 10-14 part, Radix Pseudostellariae 10-14 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition for the treatment of graves according to claim 3, is characterized in that, is made up of the Chinese medicine of following weight portion:

Liquor Fructus Citri sarcodactylis Distillata 12 parts, Fructus Citri 12 parts, Flos Rosae Rugosae 12 parts, Nemacystus decipiens (Sur.) Kuck 12 parts, Pelvetia siliquosa Tseng et C. F. Chang 12 parts, Eucheuma gelatinosum 12 parts, Flos Rosae Chinensis 10 parts, Stigma Croci 10 parts, Radix Curcumae 10 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Radix Pseudostellariae 12 parts, 6 parts, Radix Glycyrrhizae.