CN103816339A - Traditional Chinese medicine granule for treating liver stagnation phlegm stasis type breast hyperplasia - Google Patents
Traditional Chinese medicine granule for treating liver stagnation phlegm stasis type breast hyperplasia Download PDFInfo
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- CN103816339A CN103816339A CN201410107175.2A CN201410107175A CN103816339A CN 103816339 A CN103816339 A CN 103816339A CN 201410107175 A CN201410107175 A CN 201410107175A CN 103816339 A CN103816339 A CN 103816339A
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Abstract
The invention discloses a traditional Chinese medicine granule for treating liver stagnation phlegm stasis type breast hyperplasia, belongs to the technical field and relates to a traditional Chinese medicine granule which takes radix bupleuri as a main component for treating the liver stagnation phlegm stasis type breast hyperplasia, wherein the decoction is replaced by the granule. The invention also relates to a preparation method of the granule. The granule disclosed by the invention has the main effects of soothing the liver, regulating the flow of vital energy, eliminating phlegm, softening hard mass, removing stasis and diminishing swelling; most of the traditional Chinese medicines are subjected to single-medicine pharmacological inspection; raw material sources are stable and easy to obtain; the granules are convenient to take and low in cost; no negative ecological effect and environmental pollution are caused during the production process, and good ecological benefits and prospect are achieved. Moreover, as a natural traditional Chinese medicine, the granule is good in curative effect, free of toxic and side effects, cheap in price and convenient to take.
Description
Technical field
The present invention relates to a kind of medicine take Radix Bupleuri as main treatment liver energy stagnation and phlegm accumulation type mastoproliferation, the Chinese medicine granules of specifically preparing take Chinese herbal medicine as raw material, the invention still further relates to the preparation method of this medicine.
Background technology
Current known cyclomastopathy is that a kind of epithelial cell take mammary alveolar conduit and connective tissue proliferation are basic pathology variation, the i.e. non-inflammation general name of a class disease of non-tumor again.Primary disease is apt to occur in the 30-50 women in year, and domestic more than 30 years old women prevalence is 38.6%-49.3%, and 40-49 year is onset peak, and its cancer just rate is about 20%.In recent years along with the change of people life style, the increase of life stress, the sickness rate of cyclomastopathy is obvious ascendant trend, also be tending towards rejuvenation, the potential killer of harm female body health, western medical treatment primary disease is multiplex is main to estrogen antagonist, but effect is not ideal and side effect is large, becomes the direction of TCM Gynecology doctor research therefore seek effective compound Chinese medicinal preparation.
Summary of the invention
Technical scheme: utilization Radix Bupleuri eliminating stagnation granule by weight its formula of component is: (Radix Bupleuri 630-840g, Radix Angelicae Sinensis 420-630g, Radix Paeoniae Alba 630-840g, Rhizoma Corydalis 420-505g, Radix Salviae Miltiorrhizae 630-840g, Rhizoma Cyperi 420-505g, Fructus Trichosanthis 630-840g, Sargassum 505-630g, Nidus Vespae 420-505g, Flos Albiziae 250-300g, Rhizoma Atractylodis Macrocephalae (parched) 505-630g, Radix Astragali 420-505g).Instructions of taking: every bag of 12g, each 1 bag, every day 2 times.Menstrual phase is withdrawn, and within 1 month, is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of.During treatment, do not take with primary disease and treat relevant medicine, in order to avoid the judgement that affects the treatment, monthly itemized record patient's clinical symptoms (comprising that mastalgia situation, lump in breast situation, companion see symptom and tongue arteries and veins) after menstruation.With digital staging (NRS), mammary gland pain is made to evaluation.Statistical method: all data is with SAS8.2 statistical software building database, analytical statistics meaning.Each group data acquisition is used
± s carries out descriptive statistics, and before and after self, two Sets of Measurement Datas relatively adopt t check.Enumeration data is checked with X2, and two groups of data relatively adopt Ridit to analyze.
Diagnostic criteria:
1.according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".1. many have a flat lump at the outside upper quadrant of breast, and that lays one's hand on has a tough hard tubercle of beans size, can have tenderness.Owe clearly on lump border, with surrounding tissue adhesion.2. breast can have distending pain, the often growth and decline with susceptible to anger, and month premenstrual the increasing the weight of of being everlasting, alleviates after menstruation.3. be more common in 20-40 year women.4. molybdenum palladium x-ray breast is taken the photograph sheet, cold light source strong illumination, liquid crystal thermography picture etc. inspections and is supported diagnosis.
2.traditional Chinese medical science liver energy depression and phlegm stagnation disease standard with reference to " Surgery of Chinese Medicine " formulate as follows: 1. primary symptom: distending pain of the breast or twinge, addiction piece, premenstrual addiction block length is large, through after dwindle.2. time disease: uncomfortable in chest not easypro, both sides of the chest distending pain, the impermanence of anger melancholy; Or companion's Hypomenorrhea, or abdominal pain during menstruation; Body of the tongue is light red or dark red, or has petechia, white and thin fur; Stringy pulse or puckery.All 3 of meeting in primary symptom and inferior disease can dialectically be liver energy depression and phlegm stagnation card.
3.1. case inclusive criteria meets above-mentioned Disease Diagnosis Standard and traditional Chinese medical science disease standard person; 2. age 21-48 year, the not women of menopause; 3. non-operative indication person; 4. without internal medicine complication; 5. nearly half a year is without the pregnant person of plan.
4.1. case exclusion standard merges other mastopathy person; 2. merge the heart, liver, kidney and other organs serious disease and psychotic; 3. gestation or age of sucking patient; 4. apply contraceptive and sex hormone drug person; 5. get rid of breast carcinoma, mammary gland fibroma person.
5.criterion of therapeutical effect: judge curative effect according to " traditional Chinese medical science disease Standardization of diagnosis and curative effect ".1. cure: lump disappears, mastalgia disappears, and drug withdrawal March is without recurrence; 2. effective: clinical symptom relief or disappearance, enclosed mass maximum gauge dwindles more than 1/2; 3. effective: clinical symptoms reduces or disappears, and enclosed mass dwindles more than 1/3; 4. invalid: symptom is without change, and enclosed mass has no and obviously dwindles or dwindle deficiency.
6.traditional Chinese medical science disease standard:
abdominal pain during menstruation, obtains warm alleviation of pain;
non-menstrual period hypogastralgia, sense of discomfort, increase the weight of menstrual period, lower abdomen is sent out cool, happiness temperature;
menstruation is postponed, amount less, color is dark or hold clot under the arm;
fear of cold, spiritlessness and weakness, four ends are not warm;
profuse leukorrhea, color is white, or it is rare to defecate;
tongue is dim red or light dim, or limit point has ecchymosis petechia, thin white fur of tongue or greasy, stringy pulse or heavy tight or heavy thin.Possess above
,
point one of and
,
,
one of point and the
point can be examined as cold blood stasis disease.
Goal of the invention: in order to overcome existing treatment liver energy stagnation and phlegm accumulation type mastoproliferation, adopting western medical treatment primary disease multiplex is main to estrogen antagonist, but the deficiency that effect is not ideal and side effect is large, I have invented a kind of Chinese medicine granules for the treatment of liver energy stagnation and phlegm accumulation type mastoproliferation, I,, through clinical practice for many years, think that cyclomastopathy belongs to the category of Chinese medicine " nodules of the breast ".This sick head sees the Chinese. and Huatuo's " Huatuo's Zhongzang classic ", extremely discusses in bright clear surgery monograph and sees in detail.Breast is led by Liver Channel, and property happiness bar reaches and dislikes depression." Waike Zhengzong, Orthodox Manual of External Diseases " cloud: " melancholy impairing the liver, worry impairing spleen long-pending are want at the heart; be willing to unappreciated person, cause meridians painful abdominal mass puckery, coalescent nucleation " if too depression of liver-QI of seven emotions, mechanism of qi retardance, catharsis is not normal, sees lump in breast, pain, and the growth and decline with susceptible to anger, how with being irritable and getting angry easily, being about to cry due to sadness, sentimentality etc.The liver belonging to wood, spleen pertaining to the earth, depression of liver-QI.Horizontal gram spleen soil, dysfunction of the spleen in transportation, raw in phlegm-damp, gas, blood, expectorant is condensed in newborn network,, therefore tuberosity lump is harder, the diseases such as companion's fatigue and weakness, clinical syndrome differentiation belongs to liver energy depression and phlegm stagnation.Therefore its treatment should be take depressed liver-energy dispersing and QI regulating, resolving phlegm and softening hard masses, blood circulation promoting and blood stasis dispelling as main rule.Radix Bupleuri in side, its acrid in the mouth hardship, cold nature, the cloudy Liver Channel that enters to faint, bar reaches irritability and dispersing the stagnated live-QI to relieve the stagnation of QI is declared smooth mechanism of qi, " book on Chinese herbal medicine justice " cloud: " its property is loose, therefore main ... Liver Channel melancholia ", is usually used in treating the distending pain over the hypochondrium due to depression of liver-QI.The Liver Channel gas that can fall apart gathers blood agglomeration, embodies the principle of " soothing the stagnant liver ", depressed liver-energy dispersing and QI regulating, drug for invigorating blood circulation and eliminating stasis can suppress the vigor of monoamine oxidase, MAO in tissue, suppress the synthetic of collagen fiber, and there is the effect that improves whole body and liver blood circulation, be conducive to hormone metabolism and balance in vivo.All medicines totally 5, thus can depressed liver-energy dispersing and QI regulating, resolving phlegm and softening hard masses, the effect of having cut blood stasis dispersing and deswelling, that tests is clinical, truly has curative effect.And obtain satisfactory effect.
Invention beneficial effect: treatment patient case 50 examples; Wherein: recovery from illness case 14 examples, account for 28%; Effective case 20 examples, account for 40%; Effectively case 12 examples, account for 24%; Ineffective Cases 4 examples, account for 8%; 50 routine patient treatments total effective rate 91.1% after 3 months.
1.the routine patient of mastalgia 50, recovery from illness case 14 examples, effective case 26 examples, effectively case 5 examples, Ineffective Cases 5 examples, overall effective percentage: 90.00%;
2.the routine patient of lump in breast 50, recovery from illness case 14 examples, effective case 20 examples, effectively case 10 examples, Ineffective Cases 6 examples, overall effective percentage: 88.00%;
3.the routine patient of distending pain in the chest and hypochondrium 45, recovery from illness case 25 examples, effective case 15 examples, effectively case 3 examples, Ineffective Cases 2 examples, overall effective percentage: 95.50%;
4.the routine patient of irritated irritability 42, recovery from illness case 27 examples, effective case 13 examples, effectively case 1 example, the routine patient of Ineffective Cases 2, overall effective percentage: 97.60%;
5.the routine patient of abdominal pain during menstruation 35, recovery from illness case 15 examples, effective case 15 examples, effectively case 3 examples, Ineffective Cases 2 examples, overall effective percentage: 94.28%;
6.the dim 30 routine patients of Hypomenorrhea color, recovery from illness case 15 examples, effective case 10 examples, effectively case 2 examples, Ineffective Cases 2 examples, overall effective percentage: 90.00%;
7.the routine patient of body of the tongue 50, recovery from illness case 30 examples, effective case 10 examples, effectively case 5 examples, Ineffective Cases 5 examples, overall effective percentage: 90.00%;
8.the pain intensity of passing judgment on NRS method all has obvious decline before treatment, compared with before treatment, and the 1st, after 2,3 months, NRS diversity of values has extremely significantly meaning (P≤0.01).NRS treatment front 6.1 ± 1.1; Treat January 3.0 ± 1.8; Treat February 2.16 ± 1.73; Treat March 1.73 ± 1.42.
Preferred forms: use the loose treatment of Radix Bupleuri, changing decoction is granule.
Innovation: this novel patent of invention relates to a kind of Chinese medicinal granule agent medicine take Radix Bupleuri as main treatment liver energy stagnation and phlegm accumulation type mastoproliferation, changing decoction is granule, it has overcome existing treatment liver energy stagnation and phlegm accumulation type mastoproliferation, adopting western medical treatment primary disease multiplex is main to estrogen antagonist, but the deficiency that effect is not ideal and side effect is large.Radix Bupleuri in side, its acrid in the mouth hardship, cold nature, the cloudy Liver Channel that enters to faint, bar reaches irritability and dispersing the stagnated live-QI to relieve the stagnation of QI is declared smooth mechanism of qi, " book on Chinese herbal medicine justice " cloud: " its property is loose, therefore main ... Liver Channel melancholia ", is usually used in treating the distending pain over the hypochondrium due to depression of liver-QI.The Liver Channel gas that can fall apart gathers blood agglomeration, embodies the principle of " soothing the stagnant liver ", therefore be monarch drug.Rhizoma Cyperi depressed liver-energy dispersing and QI regulating resolving depression, promoting the circulation of QI to relieve pain; Radix Paeoniae Alba easing the affected liver to relieve pain, Radix Bupleuri, Rhizoma Cyperi, the Radix Paeoniae Alba is share, and has both entered edema caused by disorder of QI, and promoting the circulation of blood divides again, for the main pathogenesis of irritability stasis; The sweet benefit of Radix Angelicae Sinensis is pungent loose, and it is logical that hardship is rushed down temperature, and matter profit and greasy has the merit of invigorating blood circulation in nourishing blood, and the perverse and unreasonable manner of irritability is held back in the nourishing blood to suppress the hyperactive liver of the Radix Angelicae Sinensis Radix Paeoniae Alba; Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, share with Radix Angelicae Sinensis, strengthens the merit of invigorating blood circulation; Rhizoma Corydalis promoting the circulation of QI to relieve pain; " Bencao Congxin " cloud: " it is strongly fragrant that Fructus Trichosanthis is soothing the liver, and profit liver is dry, and suppressing the hyperactive liver is greasy, and slow liver is anxious, solely arrogates to oneself also " is ministerial drug altogether.Sargassum eliminating phlegm and softening indurated mass, inducing diuresis to remove edema; Flos Albiziae property is sweet flat, GUIXIN Liver Channel, and resolving stagnation for tranquilization, activating collaterals to relieve pain, god's peace pain is stopped; Nidus Vespae promoting the circulation of QI to relieve pain; Rhizoma Atractylodis Macrocephalae sweet in the mouth, hardship, warm in nature, enter taste warp, invigorating the spleen for eliminating dampness, turbid with expectorant; Radix Astragali replenishing QI to invigorate the spleen, inducing diuresis to remove edema, the strong fortune of temper, expectorant is difficult life, is adjuvant drug altogether.Experiment showed, depressed liver-energy dispersing and QI regulating according to another modern pharmacology, drug for invigorating blood circulation and eliminating stasis can suppress the vigor of monoamine oxidase, MAO in tissue, suppresses the synthetic of collagen fiber, and has the effect that improves whole body and liver blood circulation, is conducive to hormone metabolism and balance in vivo.All medicines totally 5, thus can depressed liver-energy dispersing and QI regulating, resolving phlegm and softening hard masses, the effect of having cut blood stasis dispersing and deswelling, that tests is clinical, truly has curative effect.We's prescription is rigorous, effectively reduction of patient pain symptom, and the pain intensity of passing judgment on NRS method all has obvious decline before treatment, compared with before treatment, the 1st, after 2,3 months, NRS diversity of values has extremely remarkable meaning (P≤0.01).Tcm symptom and sign Index also have clear improvement.
Description: a kind of novel Chinese medicine granules take Radix Bupleuri as main treatment liver energy stagnation and phlegm accumulation type mastoproliferation, changing decoction is granule.Its formula of component is by weight: (Radix Bupleuri 630-840g, Radix Angelicae Sinensis 420-630g, Radix Paeoniae Alba 630-840g, Rhizoma Corydalis 420-505g, Radix Salviae Miltiorrhizae 630-840g, Rhizoma Cyperi 420-505g, Fructus Trichosanthis 630-840g, Sargassum 505-630g, Nidus Vespae 420-505g, Flos Albiziae 250-300g, Rhizoma Atractylodis Macrocephalae (parched) 505-630g, Radix Astragali 420-505g).Instructions of taking: every bag of 12g, each 1 bag, every day 2 times.Menstrual phase is withdrawn, and within 1 month, is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of.Radix Bupleuri in side, its acrid in the mouth hardship, cold nature, the cloudy Liver Channel that enters to faint, bar reaches irritability and dispersing the stagnated live-QI to relieve the stagnation of QI is declared smooth mechanism of qi, " book on Chinese herbal medicine justice " cloud: " its property is loose, therefore main ... Liver Channel melancholia ", is usually used in treating the distending pain over the hypochondrium due to depression of liver-QI.The Liver Channel gas that can fall apart gathers blood agglomeration, embodies the principle of " soothing the stagnant liver ", therefore be monarch drug.Rhizoma Cyperi depressed liver-energy dispersing and QI regulating resolving depression, promoting the circulation of QI to relieve pain; Radix Paeoniae Alba easing the affected liver to relieve pain, Radix Bupleuri, Rhizoma Cyperi, the Radix Paeoniae Alba is share, and has both entered edema caused by disorder of QI, and promoting the circulation of blood divides again, for the main pathogenesis of irritability stasis; The sweet benefit of Radix Angelicae Sinensis is pungent loose, and it is logical that hardship is rushed down temperature, and matter profit and greasy has the merit of invigorating blood circulation in nourishing blood, and the perverse and unreasonable manner of irritability is held back in the nourishing blood to suppress the hyperactive liver of the Radix Angelicae Sinensis Radix Paeoniae Alba; Radix Salviae Miltiorrhizae nourshing blood and promoting blood circulation, share with Radix Angelicae Sinensis, strengthens the merit of invigorating blood circulation; Rhizoma Corydalis promoting the circulation of QI to relieve pain; " Bencao Congxin " cloud: " it is strongly fragrant that Fructus Trichosanthis is soothing the liver, and profit liver is dry, and suppressing the hyperactive liver is greasy, and slow liver is anxious, solely arrogates to oneself also " is ministerial drug altogether.Sargassum eliminating phlegm and softening indurated mass, inducing diuresis to remove edema; Flos Albiziae property is sweet flat, GUIXIN Liver Channel, and resolving stagnation for tranquilization, activating collaterals to relieve pain, god's peace pain is stopped; Nidus Vespae promoting the circulation of QI to relieve pain; Rhizoma Atractylodis Macrocephalae sweet in the mouth, hardship, warm in nature, enter taste warp, invigorating the spleen for eliminating dampness, turbid with expectorant; Radix Astragali replenishing QI to invigorate the spleen, inducing diuresis to remove edema, the strong fortune of temper, expectorant is difficult life, is adjuvant drug altogether.Experiment showed, depressed liver-energy dispersing and QI regulating according to another modern pharmacology, drug for invigorating blood circulation and eliminating stasis can suppress the vigor of monoamine oxidase, MAO in tissue, suppresses the synthetic of collagen fiber, and has the effect that improves whole body and liver blood circulation, is conducive to hormone metabolism and balance in vivo.All medicines totally 5, thus can depressed liver-energy dispersing and QI regulating, resolving phlegm and softening hard masses, the effect of having cut blood stasis dispersing and deswelling, that tests is clinical, truly has curative effect.We's prescription is rigorous, effectively reduction of patient pain symptom, and the pain intensity of passing judgment on NRS method all has obvious decline before treatment, compared with before treatment, the 1st, after 2,3 months, NRS diversity of values has extremely remarkable meaning (P≤0.01).Tcm symptom and sign Index also have clear improvement.
Claims (3)
1. the novel Chinese medicinal granule agent medicine take Radix Bupleuri as main treatment liver energy stagnation and phlegm accumulation type mastoproliferation, changing decoction is granule agent; Its formula of composition by weight is: Radix Bupleuri 630-840g, Radix Angelicae Sinensis 420-630g, Radix Paeoniae Alba 630-840g, Rhizoma Corydalis 420-505g, Radix Salviae Miltiorrhizae 630-840g, Rhizoma Cyperi 420-505g, Fructus Trichosanthis 630-840g, Sargassum 505-630g, Nidus Vespae 420-505g, Flos Albiziae 250-300g, Rhizoma Atractylodis Macrocephalae (parched) 505-630g, Radix Astragali 420-505g; Instructions of taking: every bag of 12g, each 1 bag, every day 2 times; Menstrual phase is withdrawn, and within 1 month, is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of.
2. Chinese medicinal granule agent medicine according to claim 1, is characterized in that: use take Radix Bupleuri as main treatment, changing decoction is granule; Its formula of component is by weight: Radix Bupleuri 630-840g, Radix Angelicae Sinensis 420-630g, Radix Paeoniae Alba 630-840g, Rhizoma Corydalis 420-505g, Radix Salviae Miltiorrhizae 630-840g, Rhizoma Cyperi 420-505g, Fructus Trichosanthis 630-840g, Sargassum 505-630g, Nidus Vespae 420-505g, Flos Albiziae 250-300g, Rhizoma Atractylodis Macrocephalae (parched) 505-630g, Radix Astragali 420-505g.
3. Chinese medicinal granule agent medicine according to claim 1, is characterized in that: instructions of taking with formula in Chinese medicinal granule agent medicine, every bag of 12g, each 1 bag 1 month is 1 course for the treatment of, is used in conjunction 3 courses for the treatment of.
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Cited By (2)
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| CN104491544A (en) * | 2014-12-25 | 2015-04-08 | 刘新霞 | Traditional Chinese medicinal composition for treating breast hyperplasia caused by phlegm stagnation and sluggish |
| CN105641234A (en) * | 2016-01-20 | 2016-06-08 | 邢志博 | Traditional Chinese medicine composition for treating liver depression type hyperplasia of mammary glands and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104491544A (en) * | 2014-12-25 | 2015-04-08 | 刘新霞 | Traditional Chinese medicinal composition for treating breast hyperplasia caused by phlegm stagnation and sluggish |
| CN105641234A (en) * | 2016-01-20 | 2016-06-08 | 邢志博 | Traditional Chinese medicine composition for treating liver depression type hyperplasia of mammary glands and preparation method thereof |
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