CN102397368B

CN102397368B - Chinese medicinal preparation for treating cyclomastopathy

Info

Publication number: CN102397368B
Application number: CN2011103644562A
Authority: CN
Inventors: 杜凤臻
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-11-04
Filing date: 2011-11-04
Publication date: 2013-04-24
Anticipated expiration: 2031-11-04
Also published as: CN102397368A

Abstract

The invention aims to provide a Chinese medicinal preparation for treating cyclomastopathy, which has a good treatment effect and has no toxic or side effect. According to the traditional Chinese medical science, cyclomastopathy is caused by liver depression, qi stagnation, the disharmony between chong and ren and phlegm stagnation. Liver depression is the direct cause of the cyclomastopathy, so that traditional Chinese medicines, including hard shell clam, pumex, common selfheal fruit-spike, safflower, suberect spatholobus stem, motherwort herb, Chinese thorowax root, bitter orange, astragalus, large-head atractylodes rhizome, twotooth achyranthes root, peach kernel and sappan wood having the effects of soothing liver-qi stagnation, regulating qi-flowing for eliminating phlegm, softening hard lumps and dispelling nodes are prepared into a decoction for a patient to take. As proved by nearly three years of clinical test, the total effective rate is up to 96.7 percent; and the Chinese medicinal preparation has the advantages of good treatment effect, no side effect and low reoccurrence rate.

Description

A kind of Chinese medicine preparation for the treatment of cyclomastopathy

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to a kind of Chinese medicine preparation for the treatment of cyclomastopathy.

Background technology

Cyclomastopathy refers to breast epithelium and proliferation of fibrous tissue, mammary gland tissue conduit and newborn lobule degeneration structurally and the growth of carrying out property connective tissue, and its pathogenic factor mainly is because the endocrine hormone imbalance.Show according to investigations 70%～85% adult female in various degree cyclomastopathy is arranged.This disease is apt to occur in the vigorous Women of Childbearing Age of reproductive function, and its clinical manifestation is periodicity or acyclic mastalgia, and pain is confined to certain zone of breast or relates to whole breast, and symptom is generally obvious before menstruation.Palpation mammary gland tissue partial thickening or granular, streak change are touched a tender spot and are levied the positive.

The medicine for the treatment of cyclomastopathy has Western medicine and Chinese medicine.Western medicine tamoxifen and derivatives for treatment cyclomastopathy thereof have obtained clinical confirmation, but it also has some obvious side effect simultaneously.The treatment by Chinese herbs cyclomastopathy is safer, but Different therapeutical effect is larger.

Summary of the invention

The purpose of this invention is to provide that a kind of therapeutic effect is good, the Chinese medicine preparation of the treatment cyclomastopathy that has no side effect.Chinese medicine thinks that cyclomastopathy is that stagnation of QI due to depression of the liver, Chong and Ren channel disorder, expectorant become silted up to condense and form.Stagnation of liver-QI is this pathogenetic direct inducement, and with dispersing the stagnated live-QI to relieve the stagnation of QI, activating QI to eliminate phlegm, Chong and Ren Meridians regulating, hard masses softening and resolving are main in the treatment.

The objective of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment cyclomastopathy is made by the Chinese medicine of following weight portion: Carnis Mactrae 8-12 part, Pumex 7-10 part, Spica Prunellae 10-15 part, Flos Carthami 9-13 part, Caulis Spatholobi 9-13 part, Herba Leonuri 10-15 part, Radix Bupleuri 8-12 part, Fructus Aurantii 7-10 part, Radix Astragali 8-12 part, Rhizoma Atractylodis Macrocephalae 7-10 part, Radix Achyranthis Bidentatae 10-15 part, Semen Persicae 10-15 part, Lignum Sappan 5-9 part.

Preferably, the Chinese medicine preparation of this treatment cyclomastopathy is made by the Chinese medicine of following weight portion: 10 parts of Carnis Mactraes, 9 parts of Pumexs, 13 parts of Spica Prunellaes, 11 parts on Flos Carthami, 11 parts of Caulis Spatholobis, 12 parts of Herba Leonuris, 10 parts of Radix Bupleuri, 9 parts of Fructus Aurantiis, 10 parts of the Radixs Astragali, 8 parts of the Rhizoma Atractylodis Macrocephalaes, 13 parts of Radix Achyranthis Bidentataes, 12 parts in Semen Persicae, 7 parts of Lignum Sappans.

Above-mentioned Chinese medicine is fried in shallow oil into decoction by traditional method.

Carnis Mactrae, Pumex, Spica Prunellae hard masses softening and resolving in the side, removing heat from the lung and dissipating phlegm, YIN nourishing detumescence; Flos Carthami, Caulis Spatholobi, Herba Leonuri are enriched blood and are invigorated blood circulation, inducing diuresis to remove edema, heat-clearing and toxic substances removing; Radix Bupleuri, Fructus Aurantii, the Radix Astragali, Rhizoma Atractylodis Macrocephalae dispersing the stagnated live-QI to relieve the stagnation of QI, invigorating the spleen and benefiting QI, dampness diuretic; Semen Persicae, Lignum Sappan blood circulation promoting and blood stasis dispelling, subduing swelling and relieving pain; Radix Achyranthis Bidentatae invigorating the liver and kidney, bone and muscle strengthening, promoting blood circulation to restore menstrual flow, conducting blood to flow downwards, inducing diuresis for treating stranguria syndrome.All medicines are long memorial liver resolving depression, activating QI to eliminate phlegm altogether, the merit of Chong and Ren Meridians regulating, hard masses softening and resolving.

Clinical data

1, the physical data all cases all is selected from my Out-patient Department patient 184 examples of in JIUYUE, 2006 to 2008 year February, is divided at random treatment group and matched group.Treatment group 92 examples, age 17-53 year, average 35.5 years old; The course of disease is the shortest 2 months, and is the longest 10 years; One-sided ill 24 examples of breast, ill 68 examples of bilateral.Matched group 92 examples, age 16-52 year, average 35.6 years old; The course of disease is the shortest 2.5 months, and is the longest 11 years; One-sided ill 26 examples of breast, ill 66 examples of bilateral.Epidemiological Analysis by statistics, two groups of ages, the course of disease, state of an illness distributional difference have comparability without significance (P＞0.05).

2, clinical criteria is according to " Chinese Hospitals Clinics standard criterion " ... in relevant surgery of Chinese medicine disease Diagnosis of Cyclomastopathy standard: the 1. obvious distending pain of breast section, increase the weight of before the Chang Yujing, through after alleviate; 2. a plurality of circles that vary in size, tough hard tuberosity occur in the breast one or both sides, and tuberosity often is scattered in whole breast, also can be confined to an one of breast; 3. the lump obscure boundary does not link to each other with skin, push away movable, the whenever growth and decline with susceptible to anger of lump, not diabrosis.

3, the oral Chinese medicine composition of the present invention of Therapeutic Method treatment group is got Carnis Mactrae 10g, Pumex 9g, Spica Prunellae 13g, Flos Carthami 11g, Caulis Spatholobi 11g, Herba Leonuri 12g, Radix Bupleuri 10g, Fructus Aurantii 9g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 8g, Radix Achyranthis Bidentatae 13g, Semen Persicae 12g, Lignum Sappan 7g.Be decocted in water for oral dose 1 dose of every day, minute early, middle and late three decoction being taken warmly, stop using menstrual period.Per 3 weeks were 1 course for the treatment of, and every example takes 3 courses for the treatment of.The oral ease pill of matched group, 6 tablets/times, 3 times/days, per 3 weeks were 1 course for the treatment of, took 3 courses for the treatment of.

4,1. produce effects of criterion of therapeutical effect: distending pain of the breast disappears, and mammary gland is firmly tough, thickened areas disappear or significantly dwindle, matter is soft.2. alleviate: distending pain of the breast obviously alleviates, and mammary gland is firmly tough, thickened areas is dwindled.3. invalid: symptom and sign are all without obviously improving after three course of therapy.

5, add up therapeutic outcome after two groups of therapeutic outcomes are taken three courses for the treatment of: wherein the treatment group produce effects 52 (56.5%), alleviate invalid 3 examples of 37 examples (40.2%) (3.3%), total effective rate 96.7%; Matched group produce effects 28 examples (30.4%) are alleviated 43 examples (46.7%), invalid 21 examples (22.8%), total effective rate 77.2%.The treatment group curative effect is better than matched group (P＜0.01).To two groups of produce effects cases tracing study 3 months, treatment group was not found recurrent cases; Matched group is found recurrent cases 6 examples.

The specific embodiment

Embodiment one: take by weighing Carnis Mactrae 10g, Pumex 9g, Spica Prunellae 13g, Flos Carthami 11g, Caulis Spatholobi 11g, Herba Leonuri 12g, Radix Bupleuri 10g, Fructus Aurantii 9g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 8g, Radix Achyranthis Bidentatae 13g, Semen Persicae 12g, Lignum Sappan 7g.Be decocted in water for oral dose 1 dose of every day, minute early, middle and late three decoction being taken warmly, stop using menstrual period.Per 3 weeks were 1 course for the treatment of, and every example takes 3 courses for the treatment of.

Embodiment two: take by weighing Carnis Mactrae 12g, Pumex 7g, Spica Prunellae 15g, Flos Carthami 13g, Caulis Spatholobi 9g, Herba Leonuri 10g, Radix Bupleuri 8g, Fructus Aurantii 10g, Radix Astragali 12g, Rhizoma Atractylodis Macrocephalae 10g, Radix Achyranthis Bidentatae 10g, Semen Persicae 15g, Lignum Sappan 9g.Be decocted in water for oral dose 1 dose of every day, minute early, middle and late three decoction being taken warmly, stop using menstrual period.Per 3 weeks were 1 course for the treatment of, and every example takes 3 courses for the treatment of.

Embodiment three: take by weighing Carnis Mactrae 8g, Pumex 10g, Spica Prunellae 10g, Flos Carthami 9g, Caulis Spatholobi 13g, Herba Leonuri 15g, Radix Bupleuri 12g, Fructus Aurantii 7g, Radix Astragali 8g, Rhizoma Atractylodis Macrocephalae 7g, Radix Achyranthis Bidentatae 15g, Semen Persicae 10g, Lignum Sappan 5g.Be decocted in water for oral dose 1 dose of every day, minute early, middle and late three decoction being taken warmly, stop using menstrual period.Per 3 weeks were 1 course for the treatment of, and every example takes 3 courses for the treatment of.

Claims

1. Chinese medicine preparation for the treatment of cyclomastopathy is characterized in that this Chinese medicine preparation made by the Chinese medicine of following weight portion: Carnis Mactrae 10g, Pumex 9g, Spica Prunellae 13g, Flos Carthami 11g, Caulis Spatholobi 11g, Herba Leonuri 12g, Radix Bupleuri 10g, Fructus Aurantii 9g, Radix Astragali 10g, Rhizoma Atractylodis Macrocephalae 8g, Radix Achyranthis Bidentatae 13g, Semen Persicae 12g, Lignum Sappan 7g.