CN105039157A - Reaction device for synthesizing cephalosporin product by means of enzymic method - Google Patents
Reaction device for synthesizing cephalosporin product by means of enzymic method Download PDFInfo
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- CN105039157A CN105039157A CN201510506425.4A CN201510506425A CN105039157A CN 105039157 A CN105039157 A CN 105039157A CN 201510506425 A CN201510506425 A CN 201510506425A CN 105039157 A CN105039157 A CN 105039157A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/02—Percolation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
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Abstract
The invention relates to a reaction device for synthesizing a cephalosporin product by means of an enzymic method. The reaction device comprises a reaction kettle which is internally provided with a stirring paddle, wherein the bottom of the reaction kettle is provided with a screen, the upper side and the lower side of the screen are respectively provided with a sintering plate, the bottom of the reaction kettle is connected with a reaction kettle discharging system, the reaction kettle discharging system is connected with a material liquid conveying system A, a nitrogen valve is arranged between the reaction kettle discharging system and material liquid conveying system A, the material liquid conveying system A is connected with a flat-panel filtering system, a nitrogen valve is arranged between the flat-panel filtering system and the material liquid conveying system A, the flat-panel filtering system is connected with a material liquid conveying system B, the material liquid conveying system B is connected with a reaction kettle feeding control valve, and the reaction kettle feeding control valve is connected to the upper part of the reaction kettle. By adopting the reaction device, the material liquid can be circulated in the reaction process, a product in the reaction process is filtered and taken out, the reaction rate can be effectively increased, and the problem that the enzymically synthesized cephalosporin product is difficult to separate from enzyme can be solved.
Description
Technical field
The present invention relates to the technical field of chemical industry equipment, especially relate to a kind of reaction unit of enzymatic clarification cephalosporin product.
Background technology
The product separation difficulty that enzymatic clarification cephalosporin product reaction ubiquity enzyme generates with reaction, after the completion of reaction reaction mixture need be gone out suspension containing product by certain order number sieve net filtration, again the suspension containing product is filtered out product gained clear liquid will be used for washing the product mixed with enzyme, operating with this many times could be clean by the product wash-out mixed with enzyme, operation duration, quality product is easily affected.In addition, there is slow, the consuming time length of speed of reaction in enzymatic clarification part cephalo series products, the situation of unstable product quality.
Based on this, the present invention is proposed.
Summary of the invention
For the above-mentioned technical problem of prior art, the object of this invention is to provide a kind of reaction unit of enzymatic clarification cephalosporin product that can improve speed of reaction and be convenient to enzyme and product separation, feed liquid can be played circulation by this reaction unit in reaction process, the product of output in reaction process is filtered and is taken out, effectively can improve speed of reaction and solve well enzymatic clarification cephalosporin product be difficult to by enzyme with react the product separation problem generated.
For achieving the above object, the present invention is achieved by the following technical solutions:
A kind of reaction unit of enzymatic clarification cephalosporin product, comprise the reactor being built-in with stirring rake, the bottom of described reactor is provided with screen cloth, described screen cloth upper, downside is equipped with sintered plate, the bottom of described reactor is connected with reactor discharge system, described reactor discharge system is connected with feed liquid delivery system A, nitrogen valve is connected with between described reactor discharge system and feed liquid delivery system A, described feed liquid delivery system A is connected with flat panel filter system, nitrogen valve is connected with between described flat panel filter system and feed liquid delivery system A, described flat panel filter system is connected with feed liquid delivery system B, described feed liquid delivery system B is connected with reactor feed control valve, described reactor feed control valve is connected to the top of reactor.
Described reactor discharge system comprises depending on cup and look cup lower valve, described in be positioned at depending on cup the top looking cup lower valve.
Described feed liquid delivery system A comprises feed liquid transferpump A, the both sides of described feed liquid transferpump A are connected to feed liquid transferpump A material inlet valve and feed liquid transferpump A discharge valve, described feed liquid transferpump A material inlet valve is connected with reactor discharge system, and described feed liquid transferpump A discharge valve is connected with flat panel filter system.
Described flat panel filter system comprises flat-panel filter, the top of described flat-panel filter is connected with flat-panel filter material inlet valve and emptying valve, described flat-panel filter material inlet valve is connected with feed liquid delivery system A, the bottom of described flat-panel filter is connected with flat-panel filter discharge valve, and described flat-panel filter discharge valve is connected with feed liquid delivery system B.
Described feed liquid delivery system B comprises feed liquid transferpump B, described feed liquid transferpump B is connected with flat panel filter system, and feed liquid transferpump B is connected with the first discharging control valve door and the second discharging control valve door, described first discharging control valve door and the second discharging control valve door are connected in parallel on the output terminal of feed liquid transferpump B, and the first described discharging control valve door is connected with reactor feed control valve.
Beneficial effect of the present invention is as follows:
The reaction unit of enzymatic clarification cephalosporin product of the present invention, comprise the reactor of bottom with screen cloth, two nitrogen interface, two feed liquid transferpumps and strainers, feed liquid transferpump is opened and feed liquid is played circulation in reaction process, enzyme is trapped in reactor by the screen cloth bottom reactor, the product of separating out in reaction is trapped in flat-panel filter by flat-panel filter, nitrogen interface passes into nitrogen and filter cake is pressed dry rear taking-up, this process can constantly cyclical operation, repeated multiple times until react completely.Effectively improve speed of reaction, and solve the puzzlement that enzymatic clarification cephalosporin product is difficult to be separated enzyme and product well.
Accompanying drawing explanation
Fig. 1 is structural representation of the present invention;
Wherein, 1 for reactor, 2 for stirring rake, 3 for sintered plate, 4 for screen cloth, 5 be the first discharging control valve door, 6 for depending on cup, 7 for depending on cup lower valve, 8 for nitrogen valve, 9 for feed liquid transferpump A, 10 for feed liquid transferpump A material inlet valve, 11 for feed liquid transferpump A discharge valve, 12 for reactor feed control valve, 13 for flat-panel filter material inlet valve, 14 for emptying valve, 15 for flat-panel filter, 16 for flat-panel filter discharge valve, 17 for feed liquid transferpump B, 18 be the second discharging control valve door.
Embodiment
Below in conjunction with specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to this.
As shown in Figure 1, the reaction unit of enzymatic clarification cephalosporin product of the present invention, comprise the reactor 1 being built-in with stirring rake 2, stirring rake 2 is flat anchor formula stirring rake, can effectively prevent the deposition of solids of enzyme and precipitation in reaction process bottom reactor 1, the bottom of reactor 1 is provided with screen cloth 4, and the upper and lower side of screen cloth 4 is equipped with sintered plate 3, screen cloth 4 can be stainless steel mesh, and sintered plate 3 can be wide aperture sintered plate.The bottom of reactor 1 is connected with reactor discharge system, reactor discharge system is connected with feed liquid delivery system A, nitrogen valve 8 is connected with between reactor discharge system and feed liquid delivery system A, feed liquid delivery system A is connected with flat panel filter system, nitrogen valve 8 is connected with between flat panel filter system and feed liquid delivery system A, flat panel filter system is connected with feed liquid delivery system B, feed liquid delivery system B is connected with reactor feed control valve 12, and reactor feed control valve 12 is connected to the top of reactor 1.
Reactor discharge system in the present invention comprises depending on cup 6 and looks cup lower valve 7, is positioned at the top looking cup lower valve 7 depending on cup 6.
Feed liquid delivery system A in the present invention comprises feed liquid transferpump A9, the both sides of feed liquid transferpump A9 are connected to feed liquid transferpump A material inlet valve 10 and feed liquid transferpump A discharge valve 11, feed liquid transferpump A material inlet valve 10 and being connected depending on cup lower valve 7 in reactor discharge system, nitrogen valve 8 is being looked between cup lower valve 7 and feed liquid transferpump A material inlet valve 10, and feed liquid transferpump A discharge valve 11 is connected with flat panel filter system.
Flat panel filter system in the present invention comprises flat-panel filter 15, the top of flat-panel filter 15 is connected with flat-panel filter material inlet valve 13 and emptying valve 14, flat-panel filter material inlet valve 13 is connected with the feed liquid transferpump A discharge valve 11 in feed liquid delivery system A, another nitrogen valve 8 is between feed liquid transferpump A discharge valve 11 and flat-panel filter material inlet valve 13, the bottom of flat-panel filter 15 is connected with flat-panel filter discharge valve 16, and flat-panel filter discharge valve 16 is connected with feed liquid delivery system B.
Feed liquid delivery system B in the present invention comprises feed liquid transferpump B17, feed liquid transferpump B17 is connected with the flat-panel filter discharge valve 16 in flat panel filter system, and feed liquid transferpump B17 is connected with the first discharging control valve door 5 and the second discharging control valve door 18, first discharging control valve door 5 and the second discharging control valve door 18 are connected in parallel on the output terminal of feed liquid transferpump B17, first discharging control valve door 5 is connected with reactor feed control valve 12, its feed liquid is back to reactor 1 after the first discharging control valve door 5 exports, second discharging control valve door 18 is connected with subsequent processing, to subsequent processing after feed liquid exports from the second discharging control valve door 18.
Pass into nitrogen and filter cake is pressed dry rear taking-up, described process can constantly cyclical operation, repeated multiple times until react completely, namely achieve being separated of enzyme and the product generated in reaction process and mother liquor at the end of reaction, final mother liquor enters subsequent processing through the second discharging control valve door 18.
Feed liquid transferpump A9 is opened and feed liquid is played circulation by feed liquid transferpump B17 in reaction process, by the screen cloth 4 bottom reactor 1, enzyme is trapped in reactor 1, the product of separating out in reaction process is trapped in flat-panel filter 15 through flat-panel filter 15 by the product of separating out in reaction and liquid, close when being collected into a certain amount of and look cup lower valve 7, with nitrogen, filter cake is pressed dry rear taking-up, and then open and look cup lower valve 7, open feed liquid transferpump A9 and feed liquid transferpump B17 and feed liquid is played circulation, repeated multiple times until react completely with this.
The present invention changes to be needed after the completion of reaction reaction mixture to be gone out suspension containing product by certain order number sieve net filtration in the past, again the suspension containing product is filtered out product gained clear liquid will be used for washing the product mixed with enzyme, operating with this many times could be clean by the product wash-out mixed with enzyme, operation duration, the easy affected problem of quality product.Effective raising speed of reaction, and solve enzymatic clarification cephalosporin product well and be difficult to be separated the puzzlement of enzyme.
More than show and describe ultimate principle of the present invention, principal character and advantage of the present invention.The technician of the industry should understand, and the present invention is not restricted to the described embodiments, and without departing from the spirit and scope of the present invention, the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.
All all drop within protection scope of the present invention without the structural transformation done by creative work from the present invention is to devise.
Claims (5)
1. the reaction unit of an enzymatic clarification cephalosporin product, it is characterized in that: comprise the reactor being built-in with stirring rake, the bottom of described reactor is provided with screen cloth, described screen cloth upper, downside is equipped with sintered plate, the bottom of described reactor is connected with reactor discharge system, described reactor discharge system is connected with feed liquid delivery system A, nitrogen valve is connected with between described reactor discharge system and feed liquid delivery system A, described feed liquid delivery system A is connected with flat panel filter system, nitrogen valve is connected with between described flat panel filter system and feed liquid delivery system A, described flat panel filter system is connected with feed liquid delivery system B, described feed liquid delivery system B is connected with reactor feed control valve, described reactor feed control valve is connected to the top of reactor.
2. the reaction unit of enzymatic clarification cephalosporin product as claimed in claim 1, is characterized in that: described reactor discharge system comprises depending on cup and looks cup lower valve, described in be positioned at depending on cup the top looking cup lower valve.
3. the reaction unit of enzymatic clarification cephalosporin product as claimed in claim 1, it is characterized in that: described feed liquid delivery system A comprises feed liquid transferpump A, the both sides of described feed liquid transferpump A are connected to feed liquid transferpump A material inlet valve and feed liquid transferpump A discharge valve, described feed liquid transferpump A material inlet valve is connected with reactor discharge system, and described feed liquid transferpump A discharge valve is connected with flat panel filter system.
4. the reaction unit of enzymatic clarification cephalosporin product as claimed in claim 1, it is characterized in that: described flat panel filter system comprises flat-panel filter, the top of described flat-panel filter is connected with flat-panel filter material inlet valve and emptying valve, described flat-panel filter material inlet valve is connected with feed liquid delivery system A, the bottom of described flat-panel filter is connected with flat-panel filter discharge valve, and described flat-panel filter discharge valve is connected with feed liquid delivery system B.
5. the reaction unit of enzymatic clarification cephalosporin product as claimed in claim 1, it is characterized in that: described feed liquid delivery system B comprises feed liquid transferpump B, described feed liquid transferpump B is connected with flat panel filter system, and feed liquid transferpump B is connected with the first discharging control valve door and the second discharging control valve door, described first discharging control valve door and the second discharging control valve door are connected in parallel on the output terminal of feed liquid transferpump B, and the first described discharging control valve door is connected with reactor feed control valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506425.4A CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506425.4A CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
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| Publication Number | Publication Date |
|---|---|
| CN105039157A true CN105039157A (en) | 2015-11-11 |
| CN105039157B CN105039157B (en) | 2017-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510506425.4A Active CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108275867A (en) * | 2018-04-09 | 2018-07-13 | 江苏奥赛斯现代农业科技有限公司 | A kind of production of quartz tubes continuous smelting furnace feeder |
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| CN2873786Y (en) * | 2005-12-29 | 2007-02-28 | 王庆旺 | Spiral lift flow type fixed biological enzyme reactor |
| CN203320021U (en) * | 2013-05-16 | 2013-12-04 | 任峰 | Enzymolysis system |
| CN203569090U (en) * | 2013-10-17 | 2014-04-30 | 华北制药河北华民药业有限责任公司 | Reaction and separation device of enzymic-method cephalosporin products |
| CN104694388A (en) * | 2015-03-26 | 2015-06-10 | 江苏诚信药业有限公司 | Enzyme reaction automatic device system and preparation method and application thereof |
| CN204918598U (en) * | 2015-08-18 | 2015-12-30 | 浙江东盈药业有限公司 | Reaction unit of synthetic cephalo -type product of enzyme process |
-
2015
- 2015-08-18 CN CN201510506425.4A patent/CN105039157B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2873786Y (en) * | 2005-12-29 | 2007-02-28 | 王庆旺 | Spiral lift flow type fixed biological enzyme reactor |
| CN203320021U (en) * | 2013-05-16 | 2013-12-04 | 任峰 | Enzymolysis system |
| CN203569090U (en) * | 2013-10-17 | 2014-04-30 | 华北制药河北华民药业有限责任公司 | Reaction and separation device of enzymic-method cephalosporin products |
| CN104694388A (en) * | 2015-03-26 | 2015-06-10 | 江苏诚信药业有限公司 | Enzyme reaction automatic device system and preparation method and application thereof |
| CN204918598U (en) * | 2015-08-18 | 2015-12-30 | 浙江东盈药业有限公司 | Reaction unit of synthetic cephalo -type product of enzyme process |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108275867A (en) * | 2018-04-09 | 2018-07-13 | 江苏奥赛斯现代农业科技有限公司 | A kind of production of quartz tubes continuous smelting furnace feeder |
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| CN105039157B (en) | 2017-05-03 |
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