CN105039157B - Reaction device for synthesizing cephalosporin product by means of enzymic method - Google Patents
Reaction device for synthesizing cephalosporin product by means of enzymic method Download PDFInfo
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- CN105039157B CN105039157B CN201510506425.4A CN201510506425A CN105039157B CN 105039157 B CN105039157 B CN 105039157B CN 201510506425 A CN201510506425 A CN 201510506425A CN 105039157 B CN105039157 B CN 105039157B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
- C12M27/02—Stirrer or mobile mixing elements
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
- C12M29/02—Percolation
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
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Abstract
The invention relates to a reaction device for synthesizing a cephalosporin product by means of an enzymic method. The reaction device comprises a reaction kettle which is internally provided with a stirring paddle, wherein the bottom of the reaction kettle is provided with a screen, the upper side and the lower side of the screen are respectively provided with a sintering plate, the bottom of the reaction kettle is connected with a reaction kettle discharging system, the reaction kettle discharging system is connected with a material liquid conveying system A, a nitrogen valve is arranged between the reaction kettle discharging system and material liquid conveying system A, the material liquid conveying system A is connected with a flat-panel filtering system, a nitrogen valve is arranged between the flat-panel filtering system and the material liquid conveying system A, the flat-panel filtering system is connected with a material liquid conveying system B, the material liquid conveying system B is connected with a reaction kettle feeding control valve, and the reaction kettle feeding control valve is connected to the upper part of the reaction kettle. By adopting the reaction device, the material liquid can be circulated in the reaction process, a product in the reaction process is filtered and taken out, the reaction rate can be effectively increased, and the problem that the enzymically synthesized cephalosporin product is difficult to separate from enzyme can be solved.
Description
Technical field
The present invention relates to the technical field of chemical industry equipment, more particularly, to a kind of reaction dress of enzymatic clarification cephalo-type product
Put.
Background technology
Enzymatic clarification cephalo-type product reacts generally existing enzyme and separates difficulty with the product of reaction generation, need to terminate in reaction
Afterwards reactant mixture is gone out into the suspension containing product by certain mesh number screen filtration, then the suspension containing product is filtered
Going out product gained clear liquid will be for washing the product mixed with enzyme, and being operated with this will could mix many times with enzyme
Product eluting is clean, and operation duration, product quality is easily affected.In addition, enzymatic clarification part cephalo-type product is present
Reaction rate is slow, time-consuming, the situation of unstable product quality.
Based on this, the present invention is proposed.
The content of the invention
For the above-mentioned technical problem of prior art, it is an object of the invention to provide one kind can improve reaction rate and just
In enzyme and the reaction unit of the detached enzymatic clarification cephalo-type product of product, the reaction unit can during the course of the reaction by feed liquid
Circulation is played, the product of output in course of reaction is filtered and taken out, reaction rate can be effectively improved and enzyme process is solved well and closed
Into the product separation problem that cephalo-type product is difficult to generate enzyme with reaction.
To reach above-mentioned purpose, the present invention is achieved by the following technical solutions：
A kind of reaction unit of enzymatic clarification cephalo-type product, including the reactor for being built-in with stirring paddle, the reactor
Bottom be provided with screen cloth, the upper and lower side of the screen cloth is equipped with sintered plate, and the bottom of the reactor is connected with reactor discharging
System, the reactor discharge system is connected with feed liquid induction system A, the reactor discharge system and feed liquid induction system A
Between be connected with nitrogen valve, feed liquid induction system A is connected with flat panel filter system, the flat panel filter system and feed liquid
Nitrogen valve is connected between induction system A, the flat panel filter system is connected with feed liquid induction system B, the feed liquid conveying
System B is connected with reactor feed control valve, and the reactor feed control valve is connected to the top of reactor.
The reactor discharge system includes regarding cup and regarding cup lower valve, described to be located at regarding the top of cup lower valve regarding cup.
Feed liquid induction system A includes feed liquid delivery pump A, and the both sides of the feed liquid delivery pump A are connected to feed liquid
Delivery pump A material inlet valves and feed liquid delivery pump A discharge valves, the feed liquid delivery pump A material inlet valves and reactor discharge system
Connection, the feed liquid delivery pump A discharge valves are connected with flat panel filter system.
The flat panel filter system includes flat-panel filter, and the top of the flat-panel filter is connected with flat-panel filter and enters
Material valve and emptying valve, the flat-panel filter material inlet valve is connected with feed liquid induction system A, the bottom of the flat-panel filter
Portion is connected with flat-panel filter discharge valve, and the flat-panel filter discharge valve is connected with feed liquid induction system B.
Feed liquid induction system B includes that feed liquid delivery pump B, the feed liquid delivery pump B are connected with flat panel filter system, and
Feed liquid delivery pump B is connected with the first discharging control valve door and the second discharging control valve door, the first discharging control valve Men Yu
Two discharging control valve doors are connected in parallel on the outfan of feed liquid delivery pump B, and the first described discharging control valve door is controlled with reactor charging
Valve connection processed.
Beneficial effects of the present invention are as follows：
The reaction unit of enzymatic clarification cephalo-type product of the present invention, including reactor of the bottom with screen cloth, two nitrogen
Interface, two feed liquid delivery pumps and a filter, feed liquid delivery pump is opened for feed liquid to make circulation, reactor during the course of the reaction
The screen cloth of bottom is trapped in enzyme in reactor, and flat-panel filter is trapped in the product separated out in reaction in flat-panel filter,
Nitrogen interface is passed through after nitrogen press dry filter cake and takes out, this process can continuous circulate operation, it is repeated multiple times until reaction completely.
Reaction rate is effectively increased, and solves enzymatic clarification cephalo-type product well and be difficult to separate the puzzlement of enzyme and product.
Description of the drawings
Fig. 1 is the structural representation of the present invention；
Wherein, 1 be reactor, 2 be stirring paddle, 3 be sintered plate, 4 be screen cloth, 5 be the first discharging control valve door, 6 be regarding
Cup, 7 be regard cup lower valve, 8 as nitrogen valve, 9 be feed liquid delivery pump A, 10 be feed liquid delivery pump A material inlet valves, 11 be feed liquid
Delivery pump A discharge valves, 12 be reactor feed control valve, 13 be flat-panel filter material inlet valve, 14 for emptying valve, 15
For flat-panel filter, 16 be flat-panel filter discharge valve, 17 be feed liquid delivery pump B, 18 be the second discharging control valve door.
Specific embodiment
With reference to specific embodiment, the present invention is further illustrated, but protection scope of the present invention is not limited to
This.
As shown in figure 1, the reaction unit of enzymatic clarification cephalo-type product of the present invention, including the reaction for being built-in with stirring paddle 2
Kettle 1, stirring paddle 2 is flat anchor formula stirring paddle, can effectively prevent enzyme and the solid of precipitation in course of reaction to be deposited on the bottom of reactor 1
Portion, the bottom of reactor 1 is provided with screen cloth 4, and the upper and lower side of screen cloth 4 is equipped with sintered plate 3, and screen cloth 4 can be stainless steel mesh,
Sintered plate 3 can be large aperture sintered plate.The bottom of reactor 1 is connected with reactor discharge system, and reactor discharge system connects
Feed liquid induction system A is connected to, nitrogen valve 8, feed liquid delivery system are connected between reactor discharge system and feed liquid induction system A
System A is connected with flat panel filter system, and nitrogen valve 8, flat panel filter are connected between flat panel filter system and feed liquid induction system A
System is connected with feed liquid induction system B, and feed liquid induction system B is connected with reactor feed control valve 12, reactor charging control
Valve processed 12 is connected to the top of reactor 1.
Reactor discharge system in the present invention includes regarding cup 6 and regarding cup lower valve 7, is located at regarding cup lower valve 7 depending on cup 6
Top.
Feed liquid induction system A in the present invention includes feed liquid delivery pump A9, and the both sides of feed liquid delivery pump A9 are connected to
Feed liquid delivery pump A material inlet valves 10 and feed liquid delivery pump A discharge valves 11, feed liquid delivery pump A material inlet valves 10 go out with reactor
Connecting depending on cup lower valve 7 in material system, nitrogen valve 8 be located at regard cup lower valve 7 and feed liquid delivery pump A material inlet valves 10 it
Between, feed liquid delivery pump A discharge valves 11 are connected with flat panel filter system.
Flat panel filter system in the present invention includes flat-panel filter 15, and the top of flat-panel filter 15 is connected with flat board mistake
Filter material inlet valve 13 and emptying valve 14, the feed liquid delivery pump A in flat-panel filter material inlet valve 13 and feed liquid induction system A
Discharge valve 11 connects, and another nitrogen valve 8 is located at feed liquid delivery pump A discharge valves 11 and flat-panel filter material inlet valve 13
Between, the bottom of flat-panel filter 15 is connected with flat-panel filter discharge valve 16, flat-panel filter discharge valve 16 and feed liquid
Induction system B connects.
Feed liquid induction system B in the present invention includes feed liquid delivery pump B17, feed liquid delivery pump B17 and flat panel filter system
In flat-panel filter discharge valve 16 connect, and feed liquid delivery pump B17 is connected with the first discharging control valve door 5 and the second discharging
Control valve 18, the first discharging control valve door 5 and the second discharging control valve door 18 are connected in parallel on the outfan of feed liquid delivery pump B17,
First discharging control valve door 5 is connected with reactor feed control valve 12, and its feed liquid is returned from after the output of the first discharging control valve door 5
To reactor 1, the second discharging control valve door 18 is connected with subsequent processing, and feed liquid is from after the output of the second discharging control valve door 18 under
One operation.
Be passed through after nitrogen press dry filter cake and take out, the process can continuous circulate operation, it is repeated multiple times up to having reacted
Entirely, enzyme is realized at the end of reaction and is separated with the product and mother solution that generate in course of reaction, final mother solution Jing second discharges
Control valve 18 enters subsequent processing.
Feed liquid delivery pump A9 and feed liquid delivery pump B17 is opened in course of reaction feed liquid is played into circulation, by the bottom of reactor 1
Screen cloth 4 enzyme is trapped in reactor 1, in reaction separate out product and liquid Jing flat-panel filters 15 will in course of reaction analyse
The product for going out is trapped in flat-panel filter 15, collect to it is a certain amount of when close regard cup lower valve 7, after with nitrogen filter cake is pressed dry
Take out, then open again regarding cup lower valve 7, open feed liquid delivery pump A9 and feed liquid delivery pump B17 and feed liquid is played into circulation, it is anti-with this
It is multiple repeatedly complete up to reaction.
The present invention change in the past need to after the completion of reaction by reactant mixture by certain mesh number screen filtration go out containing
The suspension of product, then by the suspension containing product filter out product gained clear liquid will be for washing the product mixed with enzyme
Product, being operated with this many times could be clean by the product eluting mixed with enzyme, and operation duration, product quality is easily subject to
The problem of impact.Reaction rate is effectively improved, and solves enzymatic clarification cephalo-type product well and be difficult to separate the puzzlement of enzyme.
Ultimate principle, principal character and the advantages of the present invention of the present invention has been shown and described above.The technology of the industry
Personnel it should be appreciated that the present invention is not restricted to the described embodiments, without departing from the spirit and scope of the present invention, this
Bright also to have various changes and modifications, these changes and improvements are both fallen within scope of the claimed invention.Application claims
Protection domain is by appending claims and its equivalent thereof.
All all fall within the present invention's without the reconfiguration done by creative work from the present invention is to devise
Within protection domain.
Claims (5)
1. a kind of reaction unit of enzymatic clarification cephalo-type product, it is characterised in that：Including the reactor for being built-in with stirring paddle, institute
The bottom for stating reactor is provided with screen cloth, and the upper and lower side of the screen cloth is equipped with sintered plate, and the bottom of the reactor is connected with instead
Kettle discharge system, the reactor discharge system is answered to be connected with feed liquid induction system A, the reactor discharge system and feed liquid are defeated
Send and be connected between system A nitrogen valve, feed liquid induction system A is connected with flat panel filter system, the flat panel filter system
Nitrogen valve is connected between system and feed liquid induction system A, the flat panel filter system is connected with feed liquid induction system B, described
Feed liquid induction system B is connected with reactor feed control valve, and the reactor feed control valve is connected to the upper of reactor
Portion.
2. the reaction unit of enzymatic clarification cephalo-type product as claimed in claim 1, it is characterised in that：The reactor discharging system
System includes regarding cup and regarding cup lower valve, described to be located at regarding the top of cup lower valve regarding cup.
3. the reaction unit of enzymatic clarification cephalo-type product as claimed in claim 1, it is characterised in that：The feed liquid induction system
A includes feed liquid delivery pump A, and the both sides of the feed liquid delivery pump A are connected to feed liquid delivery pump A material inlet valves and feed liquid conveying
Pump A discharge valves, the feed liquid delivery pump A material inlet valves are connected with reactor discharge system, the feed liquid delivery pump A outlet valves
Door is connected with flat panel filter system.
4. the reaction unit of enzymatic clarification cephalo-type product as claimed in claim 1, it is characterised in that：The flat panel filter system
Including flat-panel filter, the top of the flat-panel filter is connected with flat-panel filter material inlet valve and emptying valve, described flat
Panel filter material inlet valve is connected with feed liquid induction system A, and the bottom of the flat-panel filter is connected with flat-panel filter discharging
Valve, the flat-panel filter discharge valve is connected with feed liquid induction system B.
5. the reaction unit of enzymatic clarification cephalo-type product as claimed in claim 1, it is characterised in that：The feed liquid induction system
B includes feed liquid delivery pump B, and the feed liquid delivery pump B is connected with flat panel filter system, and feed liquid delivery pump B is connected with first and goes out
Material control valve and the second discharging control valve door, the first discharging control valve door and the second discharging control valve door are connected in parallel on feed liquid
The outfan of delivery pump B, the first described discharging control valve door is connected with reactor feed control valve.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506425.4A CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510506425.4A CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105039157A CN105039157A (en) | 2015-11-11 |
| CN105039157B true CN105039157B (en) | 2017-05-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510506425.4A Active CN105039157B (en) | 2015-08-18 | 2015-08-18 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108275867A (en) * | 2018-04-09 | 2018-07-13 | 江苏奥赛斯现代农业科技有限公司 | A kind of production of quartz tubes continuous smelting furnace feeder |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2873786Y (en) * | 2005-12-29 | 2007-02-28 | 王庆旺 | Spiral lift flow type fixed biological enzyme reactor |
| CN203320021U (en) * | 2013-05-16 | 2013-12-04 | 任峰 | Enzymolysis system |
| CN203569090U (en) * | 2013-10-17 | 2014-04-30 | 华北制药河北华民药业有限责任公司 | Reaction and separation device of enzymic-method cephalosporin products |
| CN104694388A (en) * | 2015-03-26 | 2015-06-10 | 江苏诚信药业有限公司 | Enzyme reaction automatic device system and preparation method and application thereof |
| CN204918598U (en) * | 2015-08-18 | 2015-12-30 | 浙江东盈药业有限公司 | Reaction unit of synthetic cephalo -type product of enzyme process |
-
2015
- 2015-08-18 CN CN201510506425.4A patent/CN105039157B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2873786Y (en) * | 2005-12-29 | 2007-02-28 | 王庆旺 | Spiral lift flow type fixed biological enzyme reactor |
| CN203320021U (en) * | 2013-05-16 | 2013-12-04 | 任峰 | Enzymolysis system |
| CN203569090U (en) * | 2013-10-17 | 2014-04-30 | 华北制药河北华民药业有限责任公司 | Reaction and separation device of enzymic-method cephalosporin products |
| CN104694388A (en) * | 2015-03-26 | 2015-06-10 | 江苏诚信药业有限公司 | Enzyme reaction automatic device system and preparation method and application thereof |
| CN204918598U (en) * | 2015-08-18 | 2015-12-30 | 浙江东盈药业有限公司 | Reaction unit of synthetic cephalo -type product of enzyme process |
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| Publication number | Publication date |
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| CN105039157A (en) | 2015-11-11 |
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