CN104694388A - Enzyme reaction automatic device system and preparation method and application thereof - Google Patents
Enzyme reaction automatic device system and preparation method and application thereof Download PDFInfo
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- CN104694388A CN104694388A CN201510133961.4A CN201510133961A CN104694388A CN 104694388 A CN104694388 A CN 104694388A CN 201510133961 A CN201510133961 A CN 201510133961A CN 104694388 A CN104694388 A CN 104694388A
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- enzyme
- resin column
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Abstract
The invention provides an enzyme reaction automatic device system. The enzyme reaction automatic device system comprises a reaction device, a stirring device, a resin column and a pump; the stirring device is located in the synthetic reaction device; the resin column is filled with resin; an outlet is formed in the bottom of the reaction device, and the pump is located at the downstream of the outlet of the reaction device and the upstream of the resin column. The enzyme reaction automatic device system is suitable for the field of pharmacies, cosmetics and fine chemical engineering.
Description
Technical field
The present invention relates to a kind of chemical reaction equipment, be specifically related to a kind of enzyme reaction automatic device system and its preparation method and application.
Background technology
In pharmacy, makeup and other field of fine chemical, conventional processing routes is complicated, and process control link is many, produces the three wastes large to environmental influence.In recent years, the research of international developed country adopts enzyme to catalyze and synthesize, and can shorten original pure chemistry technique, mild condition, is more conducive to Artificial Control operation.But in existing enzymic catalytic reaction, the consumption of enzyme hold and control techniques more difficult, operator will grasp the amount that enzyme consumes during the course, need to supplement appropriate enzyme in time, the workload of increase operator.Once the consumption of enzyme is improper, too much very few, all can affect the carrying out of reaction and the quality of target product.
Summary of the invention
In order to solve the problem, first object of the present invention is to provide a kind of enzyme reaction automatic device system.
Second object of the present invention is to provide the preparation method adopting enzyme reaction automatic device system.
3rd object of the present invention is the application providing a kind of enzyme reaction automatic device system.
Enzyme reaction automatic device system technical scheme provided by the invention:
Comprise reaction unit, whipping appts, resin column, pump; Described whipping appts is positioned at described reaction unit; Potting resin in described resin column; Outlet is arranged at the bottom of described reaction unit, and described pump is positioned at the described downstream of reaction unit outlet and the upstream of described resin column.
As preferably, the outlet of described reaction unit is connected to threeway, and other two ports of this threeway connect one end of outlet end and described pump respectively, and the upstream of described outlet end is provided with control valve.
As preferably, the resin of filling in described resin column is immobilized enzyme resin, is full of enzyme liquid in this resin column.
The preparation method of employing enzyme reaction automatic device system provided by the invention
Reaction solution in described reaction unit (1) is extracted into described resin column (3) by described pump (4), upwards fully contact with described mixed with resin from the bottom of this resin column (3), enzyme liquid is added in reaction solution, and get back to described reaction unit (1) from the top of described resin column (3), complete a circulation; Described whipping appts (2) Keep agitation reaction solution, reaction solution circulates through described resin column, evenly supplements enzyme liquid.
The application of enzyme reaction automatic device system provided by the invention: described enzyme reaction automatic device system is applied to the synthesis technique adopting the pharmacy of enzyme reaction, makeup and fine chemistry industry.
Advantageous Effects of the present invention:
The present invention's pump as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit to resin column, return reaction unit, also can visual response situation, stop the operation of pump.In reaction unit, enzyme liquid plays the effect catalyzed and synthesized, along with the carrying out of building-up reactions, enzyme liquid is consumed, under the effect of pump, reaction solution is through resin column, can supplement enzyme liquid, the velocity of flow according to reaction solution regulates, and carrys out the amount that equal control supplements enzyme liquid, save the troublesome operation that artificial process adds enzyme, also avoid the situation because misoperation causes enzyme amount too much or very few.When in reaction solution, target product concentration reaches certain value, the operation of pump can be stopped, opening control valve, collect reaction solution from outlet end, refine for further separating-purifying, obtain finished product.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of invention.
Embodiment
Below in conjunction with specific embodiment, set forth the present invention further.Should be understood that these embodiments are only not used in for illustration of the present invention to limit the scope of the invention.
Embodiment 1
As shown in Figure 1, a kind of enzyme reaction automatic device system, comprises reaction unit 1, whipping appts 2, resin column 3, pump 4; Described whipping appts 2 is positioned at described reaction unit 1; Potting resin in described resin column 3, in the present embodiment, the resin of filling in described resin column 3 is immobilized enzyme resin, is full of enzyme liquid in this resin column 3.Outlet is arranged at the bottom of described reaction unit 1, in the present embodiment, this outlet is connected to threeway, and other two ports of this threeway connect one end of outlet end 5 and described pump 4 respectively, the other end of described pump 4 is positioned at the upstream of described resin column 3, and the upstream of described outlet end 5 is provided with control valve 6.
The preparation method of employing enzyme reaction automatic device system provided by the invention
Reaction solution in described reaction unit 1 is extracted into described resin column 3 by described pump 4, upwards fully contact with described mixed with resin from the bottom of this resin column 3, add enzyme liquid in reaction solution, and get back to described reaction unit 1 from the top of described resin column 3, complete a circulation; Described whipping appts 2 Keep agitation reaction solution, reaction solution circulates through described resin column, evenly supplements enzyme liquid.
The present invention with pump 4 as reaction solution transmitting power, can automatic continuous circulation by reaction solution from reaction unit 1 to resin column 3, return reaction unit 1, also can visual response situation, stop the operation of pump.In reaction unit 1, enzyme liquid plays the effect catalyzed and synthesized, along with the carrying out of building-up reactions, enzyme liquid is consumed, under the effect of pump 4, reaction solution is when resin column 3, can supplement enzyme liquid, the velocity of flow according to reaction solution regulates, and carrys out the amount that equal control supplements enzyme liquid, save the troublesome operation that artificial process adds enzyme, also avoid the situation because misoperation causes enzyme amount too much or very few.When in reaction solution, target product concentration reaches certain value, the operation of pump 4 can be stopped, collecting reaction solution from outlet end, refine for further separating-purifying, obtain finished product.
The application of enzyme reaction automatic device system provided by the invention: described enzyme reaction automatic device system is applied to the synthesis technique adopting the pharmacy of enzyme reaction, makeup and fine chemistry industry.
Present specification describes some embodiments, but should be understood that those skilled in the art pass through to read this specification sheets and can know the various improvement not deviating from the spirit and scope of the present invention.Therefore, these other embodiments also should be included within the scope of appended claims.
Claims (5)
1. an enzyme reaction automatic device system, is characterized by: comprise reaction unit (1), whipping appts (2), resin column (3), pump (4); Described whipping appts (2) is positioned at described synthetic reaction device (1); Described resin column (3) interior potting resin; Outlet is arranged at the bottom of described reaction unit (1), and described pump (4) is positioned at the upstream of downstream that described reaction unit (1) exports and described resin column (3).
2. enzyme reaction automatic device system according to claim 1, it is characterized in that, the outlet of described reaction unit (1) is connected to threeway, other two ports of this threeway connect one end of outlet end (5) and described pump (4) respectively, and the upstream of described outlet end (5) is provided with control valve (6).
3. enzyme reaction automatic device system according to claim 1, is characterized in that, the resin of filling in described resin column (3) is immobilized enzyme resin, and this resin column is full of enzyme liquid in (3).
4. one kind adopts the preparation method of enzyme reaction automatic device system according to claim 1, it is characterized by: the reaction solution in described reaction unit (1) is extracted into described resin column (3) by described pump (4), upwards fully contact with described mixed with resin from the bottom of this resin column (3), enzyme liquid is added in reaction solution, and get back to described reaction unit (1) from the top of described resin column (3), complete a circulation; Described whipping appts (2) Keep agitation reaction solution, reaction solution circulates through described resin column, evenly supplements enzyme liquid.
5. an application for enzyme reaction automatic device system as claimed in claim 1, is characterized by: described enzyme reaction automatic device system is applied to the synthesis technique adopting the pharmacy of enzyme reaction, makeup and fine chemistry industry.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510133961.4A CN104694388A (en) | 2015-03-26 | 2015-03-26 | Enzyme reaction automatic device system and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510133961.4A CN104694388A (en) | 2015-03-26 | 2015-03-26 | Enzyme reaction automatic device system and preparation method and application thereof |
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| Publication Number | Publication Date |
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| CN104694388A true CN104694388A (en) | 2015-06-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201510133961.4A Pending CN104694388A (en) | 2015-03-26 | 2015-03-26 | Enzyme reaction automatic device system and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105039157A (en) * | 2015-08-18 | 2015-11-11 | 浙江东盈药业有限公司 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
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| CN2362866Y (en) * | 1999-02-11 | 2000-02-09 | 中国牧工商(集团)总公司 | Hyaluronic cell lactase hollow fibre biochemical reactor |
| CN201525847U (en) * | 2009-07-21 | 2010-07-14 | 南京工业大学 | Immobilized enzyme carrier preparation device |
| CN101845470A (en) * | 2009-03-25 | 2010-09-29 | 中国科学院大连化学物理研究所 | Method for producing fructooligosaccharid and high fructose syrup by using immobilized enzyme |
| CN102604828A (en) * | 2011-01-24 | 2012-07-25 | 上海众伟生化有限公司 | Double-body circulatory cellulose enzymatic hydrolysis reactor and application thereof |
| CN103131626A (en) * | 2011-11-28 | 2013-06-05 | 西安瑞捷生物科技有限公司 | Biological enzyme hydrolysis reaction device |
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2015
- 2015-03-26 CN CN201510133961.4A patent/CN104694388A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2362866Y (en) * | 1999-02-11 | 2000-02-09 | 中国牧工商(集团)总公司 | Hyaluronic cell lactase hollow fibre biochemical reactor |
| CN101845470A (en) * | 2009-03-25 | 2010-09-29 | 中国科学院大连化学物理研究所 | Method for producing fructooligosaccharid and high fructose syrup by using immobilized enzyme |
| CN201525847U (en) * | 2009-07-21 | 2010-07-14 | 南京工业大学 | Immobilized enzyme carrier preparation device |
| CN102604828A (en) * | 2011-01-24 | 2012-07-25 | 上海众伟生化有限公司 | Double-body circulatory cellulose enzymatic hydrolysis reactor and application thereof |
| CN103131626A (en) * | 2011-11-28 | 2013-06-05 | 西安瑞捷生物科技有限公司 | Biological enzyme hydrolysis reaction device |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105039157A (en) * | 2015-08-18 | 2015-11-11 | 浙江东盈药业有限公司 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
| CN105039157B (en) * | 2015-08-18 | 2017-05-03 | 浙江东盈药业有限公司 | Reaction device for synthesizing cephalosporin product by means of enzymic method |
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Application publication date: 20150610 |