CN105031419A - Composition with hangover-alleviating and liver-protecting effects and preparation method of composition - Google Patents
Composition with hangover-alleviating and liver-protecting effects and preparation method of composition Download PDFInfo
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Abstract
The invention discloses a composition with hangover-alleviating and liver-protecting effects and a preparation method of the composition. The composition with the hangover-alleviating and liver-protecting effects is prepared from ten medicinal materials: puerarin, hovenia dulcis thumb, waxberry, hawthorn, malt, poria cocos, spina date seed, finger citron, gorgon euryale seed and chrysanthemum. The preparation method comprises the following steps: selecting various raw materials according to the formula of the composition; extracting the raw materials by water or an ethanol-water mixed solvent; and concentrating an extracting solution, mixing, and drying to obtain the composition, wherein appropriate accessories can be added to prepare corresponding oral preparations, such as tablets, capsules, granules and oral liquids according to the requirements. The composition disclosed by the invention is prepared from selected medical and edible medicinal materials; and an experiment shows that the composition has the efficacies of alleviating the hangover and protecting the liver, and can be applied to related functional foods or medicines.
Description
Technical field
The present invention relates to a kind of compositions with effects of relieving alcoholism and protecting liver, the present invention relates to the preparation method of the compositions of this effects of relieving alcoholism and protecting liver simultaneously, belongs to health food and medicine field.
Technical background
Drinking is a kind of cooking culture phenomenon that the whole world is popularized.E-at pleasure, drink with measure can make the blood circulation of human body accelerate, and mental relaxation, easily falls asleep, and is conducive to healthy; If but excessive drinking, gastric mucosa can be caused impaired, compromised liver function, central nervous system benumbs, lethargy etc., and long-term alcohol is excessive may cause the diseases such as liver cirrhosis, hypertension, intellectual deterioration further, forms injury to health.On the other hand, because liver is unique organ of alcohol metabolism, long-term alcohol also can have an impact to liver function, severe patient even causes the diseases such as alcoholic liver.Therefore, adopt some to have relieving alcoholism and protecting the liver, functional food, the medicine of alleviating discomfort after drinking have clear and definite market using value.
The present inventor, through a large amount of research and experiment, develops the new formula be made up of 10 taste medicine-food two-purpose materials such as Radix Puerariae, Semen Hoveniae (Fructus Hoveniae), Fructus Myricae rubrae, Fructus Crataegis first, has the effects such as clear and definite relieving the effect of alcohol, protects the liver.Through further investigation further, complete the present invention.
Summary of the invention
The object of this invention is to provide a kind of compositions with effects of relieving alcoholism and protecting liver.
Described compositions is counted by weight, composed of the following components: Radix Puerariae 1-20 part, Semen Hoveniae (Fructus Hoveniae) 1-20 part, Fructus Myricae rubrae 1-20 part, Fructus Crataegi (stir-fry) 1-20 part, Fructus Hordei Germinatus (stir-fry) 1-20 part, Poria 1-20 part, Semen Ziziphi Spinosae 1-20 part, Fructus Citri Sarcodactylis 1-20 part, Semen Euryales 1-10 part, Flos Chrysanthemi 1-10 part.
Described compositions is counted by weight, can be optimized for following component composition: Radix Puerariae 2-15 part, Semen Hoveniae (Fructus Hoveniae) 2-15 part, Fructus Myricae rubrae 2-15 part, Fructus Crataegi (stir-fry) 2-15 part, Fructus Hordei Germinatus (stir-fry) 2-15 part, Poria 2-15 part, Semen Ziziphi Spinosae 2-15 part, Fructus Citri Sarcodactylis 2-15 part, Semen Euryales 1-5 part, Flos Chrysanthemi 1-5 part.
Described compositions is counted by weight, can be optimized for following component composition further: Radix Puerariae 3-10 part, Semen Hoveniae (Fructus Hoveniae) 3-10 part, Fructus Myricae rubrae 3-10 part, Fructus Crataegi (stir-fry) 3-10 part, Fructus Hordei Germinatus (stir-fry) 3-10 part, Poria 2-10 part, Semen Ziziphi Spinosae 2-10 part, Fructus Citri Sarcodactylis 2-5 part, Semen Euryales 1-5 part, Flos Chrysanthemi 1-5 part.
The present invention further provides the method for the extract described in preparation with effects of relieving alcoholism and protecting liver, comprise following processing step: choose each component raw material by composite formula, adopt water or alcohol-water mixed solvent to extract, extracting solution concentrates, mixing, dry, obtain described compositions.
In described processing step, each component raw material is optionally extracted separately or mixed extraction, and extracting mode optionally adopts water or alcohol-water mixed solvent to extract, the preferred 60-80% ethanol of described alcohol-water mixed solvent.Preferably, Fructus Myricae rubrae adopts water extraction separately.
The compositions with effects of relieving alcoholism and protecting liver of the present invention, can add proper auxiliary materials as required and make corresponding oral formulations, such as tablet, capsule, granule, oral liquid etc.
The compositions with effects of relieving alcoholism and protecting liver of the present invention, by selected traditional medicine-food two-purpose medical material with hepatoprotective effect, through research and test-meal repeatedly, finishing screen selects this compositions optimization of C/C composites.Prove through animal experiment, there is pre-preventing drunkenness, relieve the effect of alcohol, the effect such as liver-protecting and blood fat-reducing.By crowd's test-meal, prove pre-preventing drunkenness, alleviate the effective percentage of being still drank after a night and be about 80%.By process optimization, described preparation method is extracted each component active component effectively, concise in technology, workable, is easy to realize industrialization and amplifies.
Content of the present invention is completed by lot of experiments and process optimization analysis, is described with following specific embodiment.
Detailed description of the invention
The compositions with effects of relieving alcoholism and protecting liver of the present invention is by the method manufacture represented by following examples, and involved method is the technological means that those skilled in the art can grasp and use.But following examples must not be interpreted as the restriction to this area invention claim of going up in all senses.
Embodiment 1: the preparation (1) of composite formula one
Formula: count by weight, Radix Puerariae 10 parts, Semen Hoveniae (Fructus Hoveniae) 10 parts, 10 parts, Fructus Myricae rubrae, Fructus Crataegi (stir-fry) 8 parts, 8 parts, Fructus Hordei Germinatus (stir-fry), 5 parts, Poria, Semen Ziziphi Spinosae 5 parts, Fructus Citri Sarcodactylis 5 parts, Semen Euryales 3 parts, Flos Chrysanthemi 3 parts.
Preparation technology: by above formula, Fructus Myricae rubrae uses separately 10 times of water reflux, extract, 2 times, each 1 hour, and extracting solution concentrates; All the other nine taste components 15 times of water reflux, extract, 2 times, each 2 hours, extracting solution concentrated, and adds Fructus Myricae rubrae concentrated solution, and mixing, spraying dry, obtains described compositions (two power).
Embodiment 2: the preparation (2) of composite formula one
Formula: with embodiment 1.
Preparation technology: by above formula, Fructus Myricae rubrae uses separately 10 times of water reflux, extract, 2 times, each 1 hour, and extracting solution concentrates; All the other nine taste components 10 times of 60% alcohol reflux 2 times, each 2 hours, extracting solution concentrated, and adds Fructus Myricae rubrae concentrated solution, and mixing, 80 degree of forced air dryings, to obtain final product.
Embodiment 3: the preparation (3) of composite formula one
Formula: with embodiment 1.
Preparation technology: by above formula, Fructus Myricae rubrae uses separately 10 times of water reflux, extract, 2 times, each 1 hour, and extracting solution concentrates; All the other nine taste components 10 times of water reflux, extract, 1 time, then use 80% alcohol reflux 1 time, extract 2 hours at every turn, and extracting solution concentrates, and adds Fructus Myricae rubrae concentrated solution, and mixing, 80 degree of forced air dryings, to obtain final product.
Embodiment 4: the preparation (4) of composite formula one
Formula: with embodiment 1.
Preparation technology: Example 1 resulting composition, adds the flavoring agent such as appropriate amount of essence, sucralose, adds the adjuvants such as appropriate Sorbitol, lactose, microcrystalline Cellulose, magnesium stearate, mixing, tabletting, coating, makes the two power chewable tablet of 2 grams/piece.
Embodiment 5: the preparation (5) of composite formula one
Formula: with embodiment 1.
Preparation technology: Example 1 resulting composition, adds the flavoring agent such as appropriate amount of essence, sucralose, adds appropriate Sorbitol, lactose, microcrystalline Cellulose is adjuvant, through mixing, soft material processed, drying, add magnesium stearate mixing, make granule.
Embodiment 6: the preparation (6) of composite formula one
Formula: with embodiment 1.
Preparation technology: Example 1 resulting composition, adds the flavoring agent such as appropriate amount of essence, sucralose, adds water, white sugar, fruit juice is adjuvant, dissolve, stir, filter, make oral liquid.
Embodiment 7: the preparation of composite formula two
Formula: count by weight, Radix Puerariae 15 parts, Semen Hoveniae (Fructus Hoveniae) 15 parts, 10 parts, Fructus Myricae rubrae, Fructus Crataegi (stir-fry) 10 parts, 10 parts, Fructus Hordei Germinatus (stir-fry), 8 parts, Poria, Semen Ziziphi Spinosae 8 parts, Fructus Citri Sarcodactylis 5 parts, Semen Euryales 5 parts, Flos Chrysanthemi 1 part.
Preparation technology: with embodiment 1.
Embodiment 8: the preparation of composite formula three
Formula: count by weight, Radix Puerariae 20 parts, Semen Hoveniae (Fructus Hoveniae) 20 parts, 20 parts, Fructus Myricae rubrae, Fructus Crataegi (stir-fry) 15 parts, 15 parts, Fructus Hordei Germinatus (stir-fry), 10 parts, Poria, Semen Ziziphi Spinosae 5 parts, Fructus Citri Sarcodactylis 10 parts, Semen Euryales 5 parts, Flos Chrysanthemi 3 parts.
Preparation technology: with embodiment 2.
Test example 1: the anti-intoxication test of pesticide effectiveness
Get KM mice (male and female dual-purpose) 50, be divided into model group, positive drug sea Wang Jin cup group (1.5g/kg), embodiment 1 sample (two power) basic, normal, high dosage group (0.3,0.6,1.2g/kg) at random, often organize 10.First gastric infusion, after 30min, gavage is to wine, to medicated wine amount 0.3ml/20g.Take righting reflex loss as sleep index, calculate tolerance time (from ethanol gavage to the time of righting reflex loss) and liquor-saturated sleep the time (from righting reflex loss to the time of recovering).Result of the test is in table 1.
Table 1 liang power is on mice tolerance time and the impact of liquor-saturated time of sleeping
Note: compare with model group, * P < 0.05, * * P < 0.01.Lower same.
Experimental result shows, the basic, normal, high dosage group of two power all can significantly improve mice drunk tolerance time, shorten the liquor-saturated of mice to sleep the time simultaneously, have significant difference (P < 0.05, P < 0.01) compared with model group.
Test example 2: the test of pesticide effectiveness of relieving the effect of alcohol
Get KM mice 50, be divided into model group, positive drug sea Wang Jin cup group (1.5g/kg), the basic, normal, high dosage group of embodiment 1 liang of power (0.3,0.6,1.2g/kg) at random, often organize 10.First gavage, to wine, to medicated wine amount 0.3ml/20g, gives administration at once after drinking.Take righting reflex loss as sleep index, calculate tolerance time (from ethanol gavage to the time of righting reflex loss) and liquor-saturated sleep the time (from righting reflex loss to the time of recovering).Result of the test is in table 2.
Table 2 liang power is on mice tolerance time and the impact of liquor-saturated time of sleeping
Experimental result shows, high, the middle dosage group of two power all can significantly improve mice drunk tolerance time, shorten the liquor-saturated of mice to sleep the time simultaneously, have significant difference (P < 0.05) compared with model group, show that two power have good antialcoholism action.
Test example 3 protects the liver test
Adopt KM mice (18-22 gram) 50, be divided into model group, negative control group, the basic, normal, high dosage group of embodiment 1 liang of power (0.3,0.6,1.2g/kg) at random, often organize 10.Every day, gavage gave given the test agent, and negative and model control group gives pure water, gives 30 days continuously.Cause liver injury model with 50% dehydrated alcohol gavage 12ml/kg after terminating, negative control group gives pure water.In the blood sampling of mouse orbit rear vein beard, separation of serum, adopts ELISA kit to detect the content of Triglycerides in Serum (TG), very low density lipoprotein (VLDL) (VLDL).Get hepatic tissue and make tissue slice, observe distribution and area that fat drops in liver, be no more than 0,1/4,2/4,3/4,4/4 to corresponding scoring 0-4 by the hepatocyte of dripping containing fat.Result is as follows.
Table 3 Serum Indexes measures
Table 4 histopathologic examination result
Result shows: model control group compares TG and VLDL content and raises statistical significance (P < 0.05) with negative control group, represents that alcoholic liver injury model is set up; Take TG, VLDL activity or content in two power basic, normal, high dosage group serum all to reduce, show that this index result is positive.Model control group compares steatosis degree and increases the weight of there is statistical significance (P < 0.05) with negative control group, represent that model is set up; The each dosage group of two power compares with model control group, and steatosis degree alleviates, and is judged as positive findings.Result of the test shows that two power can alleviate the mouse liver injury of ethanol induction.
Test example 4 human feeding trial
For proving that the present invention on people after drinking and the impact of various physiological reaction of being still drank after a night further, in embodiment 4, two power chewable tablet of preparation are as sample, will test volunteer 20 people, age 21-40 year, man 12 people, female 8 people are divided into two groups at random, and one group is negative group, and one group is test group.Before test, half an hour eats bread 100g, and after half an hour, test group takes two power chewable tablet 2, and negative group does not eat, and drinks the capacity for liquor of experiment regulation, complete every test before second day 10:00 after 30min.One week removed after date, and two groups of cross exchanged are carried out.The various indexs of being still drank after a night are added up, the results are shown in Table.
A table 5 liang power human experiment be still drank after a night reaction test result (%) feminine gender group data can increase
Result shows: test shows that the present invention can improve various bad physiological reaction after drinking, particularly the physiological reaction such as tired, anorexia, dizziness and blurred vision is improved significantly, the mental status also takes an evident turn for the better, further proof the present invention can improve emotion after drinking and the somatic reaction of people afterwards, and can alleviate sleepiness.
Claims (9)
1. there is a compositions for effects of relieving alcoholism and protecting liver, it is characterized in that being made up of Radix Puerariae 1-20 part, Semen Hoveniae (Fructus Hoveniae) 1-20 part, Fructus Myricae rubrae 1-20 part, Fructus Crataegi (stir-fry) 1-20 part, Fructus Hordei Germinatus (stir-fry) 1-20 part, Poria 1-20 part, Semen Ziziphi Spinosae 1-20 part, Fructus Citri Sarcodactylis 1-20 part, Semen Euryales 1-10 part, Flos Chrysanthemi 1-10 part.
2. the compositions with effects of relieving alcoholism and protecting liver according to claim 1, is characterised in that and is made up of Radix Puerariae 2-15 part, Semen Hoveniae (Fructus Hoveniae) 2-15 part, Fructus Myricae rubrae 2-15 part, Fructus Crataegi (stir-fry) 2-15 part, Fructus Hordei Germinatus (stir-fry) 2-15 part, Poria 2-15 part, Semen Ziziphi Spinosae 2-15 part, Fructus Citri Sarcodactylis 2-15 part, Semen Euryales 1-5 part, Flos Chrysanthemi 1-5 part.
3. the compositions with effects of relieving alcoholism and protecting liver according to claim 2, is characterised in that and is made up of Radix Puerariae 3-10 part, Semen Hoveniae (Fructus Hoveniae) 3-10 part, Fructus Myricae rubrae 3-10 part, Fructus Crataegi (stir-fry) 3-10 part, Fructus Hordei Germinatus (stir-fry) 3-10 part, Poria 2-10 part, Semen Ziziphi Spinosae 2-10 part, Fructus Citri Sarcodactylis 2-5 part, Semen Euryales 1-5 part, Flos Chrysanthemi 1-5 part.
4. the preparation method with the compositions of effects of relieving alcoholism and protecting liver according to claim 1, is characterised in that described compositions is prepared by following steps: choose each component raw material by composite formula, adopts water or alcohol-water mixed solvent to extract, extracting solution concentrates, mixing, dry, to obtain final product.
5. the preparation method with the compositions of effects of relieving alcoholism and protecting liver according to claim 4, is characterised in that described compositions preferably adopts 60-80% ethanol to extract.
6. the preparation method with the compositions of effects of relieving alcoholism and protecting liver according to claim 4, is characterised in that in described compositions, Fructus Myricae rubrae adopts water extraction separately, and extracting solution concentrates, and mixes with all the other component raw material concentrated solutions, dry, to obtain final product.
7. the compositions with effects of relieving alcoholism and protecting liver according to claim 1, the application in food.
8. the compositions with effects of relieving alcoholism and protecting liver according to claim 7, the application in health food.
9. the compositions with effects of relieving alcoholism and protecting liver according to claim 1, the application in medicine.
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| CN201510505798.XA CN105031419B (en) | 2015-08-18 | 2015-08-18 | A kind of composition and preparation method thereof with effects of relieving alcoholism and protecting liver |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362117A (en) * | 2016-10-25 | 2017-02-01 | 深圳市华岁堂健康药业有限公司 | Traditional Chinese medicine composition capable of dispelling alcohol effect and nourishing liver and preparation method thereof |
| CN107897924A (en) * | 2017-12-04 | 2018-04-13 | 德兴市宋氏葛业有限公司 | A kind of kudzuvine root starch electuary for liver-protecting sobering up and preparation method thereof |
| CN112262900A (en) * | 2020-09-02 | 2021-01-26 | 岳康医疗生物科技有限公司 | Formula and preparation method of instant solid beverage for sobering up and body building |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088830A (en) * | 1993-06-09 | 1994-07-06 | 鲁学智 | Sober-up nutrition granules and processing technology thereof |
| CN1238036C (en) * | 2002-04-03 | 2006-01-25 | 润泽堂（北京）高科技发展有限公司 | Pure natural infusion for relieving alcoholism and protecting liver and prep. thereof |
| CN103689724B (en) * | 2013-12-17 | 2015-04-29 | 缙云县天然植物养生研究所 | Functional drink for decreasing internal heat, invigorating stomach and protecting liver and preparation technology thereof |
-
2015
- 2015-08-18 CN CN201510505798.XA patent/CN105031419B/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106362117A (en) * | 2016-10-25 | 2017-02-01 | 深圳市华岁堂健康药业有限公司 | Traditional Chinese medicine composition capable of dispelling alcohol effect and nourishing liver and preparation method thereof |
| CN107897924A (en) * | 2017-12-04 | 2018-04-13 | 德兴市宋氏葛业有限公司 | A kind of kudzuvine root starch electuary for liver-protecting sobering up and preparation method thereof |
| CN112262900A (en) * | 2020-09-02 | 2021-01-26 | 岳康医疗生物科技有限公司 | Formula and preparation method of instant solid beverage for sobering up and body building |
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| CN105031419B (en) | 2019-02-22 |
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Effective date of registration: 20240523 Address after: Room 1013, Building 1, No. 502 Linping Avenue, Hangzhou Yuhang Economic Development Zone, Linping District, Hangzhou City, Zhejiang Province, 311119 Patentee after: Hangzhou Yirui Pharmaceutical Technology Co.,Ltd. Country or region after: China Address before: 1st Floor, Zhejiang University Changshu Cooperative Research Institute, No. 1-2 Research Institute Road, Economic and Technological Development Zone, Changshu City, Jiangsu Province, 215500 Patentee before: CHANGSHU QIUSHI TECHNOLOGY Co.,Ltd. Country or region before: China |
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