CN105031354B - Unio margarita capsule for treating gastroduodenal ulcer and its preparation method and application - Google Patents
Unio margarita capsule for treating gastroduodenal ulcer and its preparation method and application Download PDFInfo
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Abstract
The present invention relates to Chinese medicine preparation, particularly for Unio margarita capsule for the treatment of gastroduodenal ulcer and its preparation method and application.The Unio margarita capsule is made up of the cuttlebone of 55 70 mass parts, the fritillaria thunbergii of 8 15 mass parts, the Oleum Citri Reticulatae of 0.1 0.15 mass parts, the evodia rutaecarpa of 37 mass parts, the coptis of 24 mass parts, the caulis bambusae in taenian of 23 mass parts, the prepared RHIZOMA PINELLIZE without adju-vant of 1.5 2 mass parts, the Radix Astragali of 13 mass parts and the root of herbaceous peony of 2 2.5 mass parts, and the cuttlebone is shelled.Unio margarita capsule of the present invention is the powder of yellow-white, gas micro-perfume, mildly bitter flavor, is easy to carry about with one；Relieved pain with relieving haperacidity, the effect of astringing to arrest bleeding.It is notable for the therapeutic effect of gastric ulcer and duodenal ulcer, especially for duodenal ulcer effective up to 88%.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation, Unio margarita capsule and its preparation particularly for treatment gastroduodenal ulcer
Methods and applications.
Background technology
Gastroduodenal ulcer is common disease of digestive tract, and its main clinical manifestation is upper abdomen pain, can be dull pain,
Cusalgia, distending pain or severe pain, it is uncomfortable to can also appear as the secret anguish only in starvation.Typical person shows as continuing under slight or moderate xiphoid-process
Property pain, can by antiacid or feed alleviate.Patient has the symptoms such as periodicity upper abdomen pain, acid reflux, belch.This disease is easily repeatedly
Breaking-out, in chronic process.Gastroduodenal ulcer includes two kinds of gastric ulcer and duodenal ulcer.Duodenal ulcer is burst compared with stomach
Ulcer is common, and the former accounts for 70% according to statistics, and the latter accounts for 25%, and both and the combined Peptic Ulcer deposited account for 5%.Duodenum is burst
The generation of ulcer and gastroxia have substantial connection.Duodenal ulcer disease people, its average basal acid secretory volume and maximal acid
Secretory volume, all it is higher by much compared with normal person.
At present, it is various to treat the medicine of gastroduodenal ulcer, based on Western medicine.Western medicine has larger over the course for the treatment of
Side effect and dependence, it is necessary to long-term use.Also useful pure Chinese medicine is treated, and is not that flavour of a drug are exactly DeGrain more.It is right
The medicine or other health products for treating these symptoms still have demand.
Fritillaria is herbaceos perennial, and its bulb can hyoscine.Because its shape is gained the name,《Bencao jizhu》：" likeness in form is poly-
Bei Zi ", therefore named fritillaria.Alias：Diligent mother, bitter dish, bitter flower, empty grass, medicine are real.Fritillaria, cold nature, acrid-sweet flavor, mainly contain fritillaria
Plain first, Peininine and a kind of steroid neutral compound, have the effect of moistening lung, available for treatment exogenous cough, upper dry phlegm-syndrome contain,
Dysphoria with smothery sensation is spitted blood, had sore throat, the disease such as mammary gland inflammation caused by bleeding from five sense organs or subcutaneous tissue and galactostasis.
According to the difference of kind, fritillaria can be divided into bulbus fritillariae cirrhosae, fritillaria thunbergii and rhizoma bolbostemmae three major types.Fritillaria thunbergii is that Liliaceae is more
The underground bulb of year raw herbaceous plant fritillaria thunbergii.Because main product is gained the name in Zhejiang, therefore abbreviation bulb of thunberg fritillary.Because its originate in Zhejiang as
Mountain, therefore also known as Bulbus Fritillariae Thunbergii, abbreviation Bulbus Fritillariae Thunbergii.Because its profile is big compared with tendril-leaved fritillary bulb, therefore also known as big fritillaria, abbreviation great Bei.In Jiangsu, peace
The ground such as emblem, Hunan also produce.Modern pharmacological research confirms that fritillaria thunbergii contains a variety of alkaloids such as peimine, peimine
With alleviate bronchial muscular spasm, reduce bronchial mucosa secretion, expand pupil, reduce blood pressure, excited uterus etc. it is a variety of
Pharmacological action.In addition, fritillaria thunbergii is increasingly used in the fields such as food, health products now as medicine-food two-purpose good merchantable brand.Study and open
Fritillaria thunbergii is sent out, is advantageous to the popularization of green and healthy diet, welfare is sought to obtain for masses.
Such as Patent No. CN10151854A patent of invention, a kind of gastric ulcer and duodenal ulcer for the treatment of is disclosed
Dietotherapy medicament and preparation method, using cuttle bone, honey as primary raw material, fritillaria thunbergii is used for gastric ulcer, duodenal ulcer etc. for it
The application compatibility of aspect is fewer, needs to be excavated in this respect, the medicine or other health products for treating these symptoms are still deposited
In demand.
The content of the invention
In view of this, it is an object of the invention to provide a kind of Unio margarita capsule for being used to treat gastroduodenal ulcer.System
Into Unio margarita capsule be yellow-white powder, gas micro-perfume, mildly bitter flavor, be easy to carry about with one；Work(with relieving haperacidity analgesic, astringing to arrest bleeding
Effect.It is notable for the therapeutic effect of gastric ulcer and duodenal ulcer, and effective especially for duodenal ulcer is up to
88%.
To achieve the above object, the technical solution adopted by the present invention is as follows：
A kind of Unio margarita capsule for being used to treat gastroduodenal ulcer, is made up of following components：The extra large Piao of 55-70 mass parts
Octopus, the fritillaria thunbergii of 8-15 mass parts, the Oleum Citri Reticulatae of 0.1-0.15 mass parts, the evodia rutaecarpa of 3-7 mass parts, the Huang of 2-4 mass parts
The root of herbaceous peony of company, the caulis bambusae in taenian of 2-3 mass parts, the prepared RHIZOMA PINELLIZE without adju-vant of 1.5-2 mass parts, the Radix Astragali of 1-3 mass parts and 2-2.5 mass parts；Institute
Cuttlebone is stated to shell.
Further, the Unio margarita capsule is made up of following components：The cuttlebone of 63 mass parts, 11 mass parts fritillaria thunbergii,
The Oleum Citri Reticulatae of 0.12 mass parts, the evodia rutaecarpa of 5 mass parts, the coptis of 3 mass parts, the caulis bambusae in taenian of 2.5 mass parts, 1.6 mass parts
The root of herbaceous peony of prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali of 2 mass parts and 2.4 mass parts.
The cuttlebone is Sepiidae animal sepiella maindroni de Rochebrune or the drying inner casing of golden cuttlefish.It is distributed in Zhejiang, Fujian, Shandong
Etc. ground.Cuttlebone has the effect of astringing to arrest bleeding, relieving leukorrhea by astringents, relieving haperacidity analgesic, hygroscopic sore.Cuttlebone is usually used in treatment and spitted blood
The diseases such as bleeding from five sense organs or subcutaneous tissue, uterine bleeding are had blood in stool, emission and spermatorrhea, leukorrhea with reddish discharge, stomachache acid regurgitation, bleeding due to trauma, eczema wet sore, unhealing ulcer.
The fritillaria thunbergii is the underground bulb of Liliaceae herbaceos perennial fritillaria thunbergii.Because main product is gained the name in Zhejiang,
Therefore abbreviation bulb of thunberg fritillary.Because it originates in Xiangshan of Zhejiang Province, therefore also known as Bulbus Fritillariae Thunbergii, abbreviation Bulbus Fritillariae Thunbergii.Because its profile is big compared with tendril-leaved fritillary bulb, therefore also known as
For big fritillaria, abbreviation great Bei.Also produced on Jiangsu, Anhui, Hunan and other places.Fritillaria thunbergii bitter and it is cold in nature, enter cardiopulmonary warp, function
Removing toxic substances, it is clinical often with radix scrophulariae, oyster, dandelion, root of Chinese trichosanthes, the capsule of weeping forsythia, coix seed, cordate houttuynia, fresh Rhizoma Phragmitis, selfheal, marine alga, elder brother
The compatibilities such as cloth, curcuma zedoary are used for the cough and the swelling and pain of carbuncle poison, the treatment of not routed etc. disease of scrofula of the strongly fragrant lung of phlegm heat；With cuttle bone, forge corrugation
The medicine such as son, bletilla, the coptis, evodia rutaecarpa, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant compatibility can treat for stomachache, sour regurgitation, heartburn.Modern pharmacological research confirmation, Zhejiang
Fritillaria contains a variety of alkaloids such as peimine, and peimine, which has, to be alleviated bronchial muscular spasm, reduces bronchial mucosa
Secretion, expand pupil, reduce blood pressure, the multiple pharmacological effect such as excited uterus.
The evodia rutaecarpa alias Wu cornel, tea are peppery, paint spicy, smelly spicy tree, the pure deep and remote son of left power, rice spicy etc..Evodia rutaecarpa
Okra fruit is traditional Chinese medicine evodia rutaecarpa after brewed airing, abbreviation Wu's cornel, is bitter stomachic and analgestic, makees ascarifuge again
Medicine.Evodia rutaecarpa property heat, it is bitterly, there is the effect of eliminating cold to stop pain, stopping nausea and vomiting by lowering the adverse flow of QI, available for the treatment liver stomach cold of insufficiency type, cloudy turbid superinverse
The disease such as caused headache or gastral cavity pain.
The coptis also known as taste company, river company, Rhizoma Coptidis etc., are Ranunculaceae herbaceos perennial.The coptis has heat-clearing dry
The effect of wet, purging intense heat and detonicating.Available for treat damp and hot feeling of fullness, vomiting acid regurgitation, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, the heart
It is tired to be insomnia, blood-head tells nosebleed, hot eyes, have a toothache, quench one's thirst, the disease such as carbuncle swells furunculosis, eczema, wet sore, duct are suppurated.
The caulis bambusae in taenian is the drying intermediate layer of the stalk of grass bambusa breviflora Munro, major part allusion quotation bamboo or henon bamboo.Caulis bambusae in taenian has
The effect of clearing heat and eliminating phlegm, relieving restlessness, preventing or arresting vomiting.Phlegm is held under the arm available for treatment phlegm-heat cough, courage fire, palpitate with fear not peaceful, vexed insomnia, middle wind phlegm
The diseases such as fan, aphasia with stiff tongue, gastropyretic vomiting, pernicious vomiting, fetal irritability.
The prepared RHIZOMA PINELLIZE without adju-vant is also known as the clear water tuber of pinellia, clear summer, clear summer piece.Prepared RHIZOMA PINELLIZE without adju-vant is can after dried pinellia alum Processing methods
The part being used as medicine.Prepared RHIZOMA PINELLIZE without adju-vant has the effect of eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, available for treatment wet phlegm and cold drink, vomits
Tell, gastric disorder causing nausea, cough and phlegm, fullness in chest, phlegm and headache, dizziness and sleepless, the disease such as outer subduing inflammation.
The medicinal history for having more than 2000 years so far of the Radix Astragali.The Radix Astragali, which has, to be eliminated Jishengshenqiwan albuminuria, increases
The effect of cardiac stimulant myotility, regulation blood-sugar content.The Radix Astragali can not only coronary artery dilator, improve myocardial blood supply, improve it is immune
Function, and it is capable of the process of delaying cell aging.
The root of herbaceous peony is the root of dicotyledon medicine ranunculaceae plant Chinese herbaceous peony (cultigen).The root of herbaceous peony is cool in nature, bitter acid, micro-
It is cold, there is the effect of blood-supplementing blood-nourishing, suppressing liver-YANG, the analgesic of soft liver, astringing YIN to stop sweating, available for treatment fever due to yin deficiency, irregular menstruation,
Chest and abdomen pain over the hypochondriac region, four limbs contraction are anxious, diarrhea dysentery abdominal pain, spontaneous sweating, uterine bleeding, with inferior disease.
The second object of the present invention is to provide the method for preparing the Unio margarita capsule, and its is simple to operate, can be extensive
Production.
The preparation method of above-mentioned Unio margarita capsule, specifically includes following steps：
A. the cuttlebone powder of above-mentioned parts by weight, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony is taken to obtain group
Compound A, the Oleum Citri Reticulatae of above-mentioned parts by weight is taken to obtain compound B；
B. composition A described in step A is placed in mixer and mixed, mixed after adding compound B, is well mixed
After be placed in capsule filler carry out capsule charge；
C. step B resulting articles are processed by shot blasting in capsule polisher.
Further, the pre-treatment step in the step A is：Composition A is sterilized, pulverizes and sieves and handles to obtain extra large Piao
Octopus powder, bulb of thunberg fritillary female powder, evodiae powder, coptis powder, caulis bambusae in taenian powder, prepared RHIZOMA PINELLIZE without adju-vant powder, astragalus membranaceus powder, herbaceous peony powder.
Further, the Unio margarita capsule prepare it is further comprising the steps of：By always mixed powder is placed in capsule charge obtained by step C
Interior, encapsulated with Capsules, then packaged capsule be placed in blister packaging machine, packed with aluminum-plastic blister, you can
Obtain Unio margarita capsule.
Further, the cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, root of herbaceous peony efficient pulverizing
Machine crushes, the material after crushing, and cuttlebone, fritillaria thunbergii cross the spin vibration sieve of 60 mesh sieves of installation, and evodia rutaecarpa crosses the rotation of 50 mesh sieves of installation
Shake sieve, and the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali cross the spin vibration sieve of installation 100-120 mesh sieves, the root of herbaceous peony crosses the rotation for installing 200-260 mesh sieves
Shake sieve, and whole pulverizing medicinal materials are until by providing mesh number screen cloth.
Further, the cuttlebone powder, bulb of thunberg fritillary female powder, evodiae powder, coptis coarse powder, caulis bambusae in taenian coarse powder, prepared RHIZOMA PINELLIZE without adju-vant coarse powder, Huang
Stilbene coarse powder, the bacterium of root of herbaceous peony coarse powder cannot be greater than 5000, mould saccharomycete cannot be greater than 50.
Further, the disintegration time limited of the Unio margarita capsule finished product cannot be greater than 30 minutes.
The present invention also aims to provide above-mentioned Unio margarita capsule to be used to treat the application in duodenal ulcer.
The beneficial effects of the present invention are：
The method of the present invention for preparing Unio margarita capsule, its is simple to operate, can mass produce.Crow of the present invention
Shellfish capsule appearance is yellow-white powder, gas micro-perfume, mildly bitter flavor, is easy to carry about with one；Relieved pain with relieving haperacidity, the effect of astringing to arrest bleeding, energy
It is enough in treatment gastric ulcer and duodenal ulcer.It is notable to gastric ulcer, the therapeutic effect of duodenal ulcer, especially right
In effective up to the 88% of duodenal ulcer.
Embodiment
Illustrated embodiment is to preferably be illustrated to present disclosure, but is not that present disclosure only limits
In illustrated embodiment.Those skilled in the art according to foregoing invention content to embodiment carry out it is nonessential improvement and
Adjustment, still falls within protection scope of the present invention.Cleared out a gathering place after raw antenatal exaination and production by《Raw antenatal exaination and validation criteria management
Code》、《Pretreatment workshop extracts post standard practice instructions》、《Clear out a gathering place standard management code》Perform.
Embodiment 1 is used for the Unio margarita capsule formula for treating gastroduodenal ulcer
Formula 1：Cuttlebone (peeling) 55g, fritillaria thunbergii 15g, Oleum Citri Reticulatae 0.15g, evodia rutaecarpa 3g, coptis 2g, caulis bambusae in taenian 3g,
Prepared RHIZOMA PINELLIZE without adju-vant 1.5g, Radix Astragali 3g and root of herbaceous peony 2g.
Formula 2：Cuttlebone (peeling) 70g, fritillaria thunbergii 8g, it is Oleum Citri Reticulatae 0.1g, evodia rutaecarpa 7g, coptis 4g, caulis bambusae in taenian 2g, clear
Tuber of pinellia 3g, Radix Astragali 1g and root of herbaceous peony 2.5g.
Formula 3：Cuttlebone (peeling) 63g, fritillaria thunbergii 11g, Oleum Citri Reticulatae 0.12g, evodia rutaecarpa 5g, coptis 3g, caulis bambusae in taenian 2.5g,
Prepared RHIZOMA PINELLIZE without adju-vant 1.6g, Radix Astragali 2g and root of herbaceous peony 2.4g.
Embodiment 2 is used for the preparation technology flow for treating the Unio margarita capsule of gastroduodenal ulcer
Unio margarita capsule is made by crude drug is formulated described in embodiment one, idiographic flow is as follows：
1. the pretreatment of crude drug
Sterilization treatment is carried out to cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony, temperature is
121 DEG C, sterilization time 2 hours, medicinal material is taken out loaded in clean bucket from clean area, is weighed.
2. pulverize and sieve
Cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony are crushed with Highefficientpulverizer, are crushed
Material afterwards, cuttlebone, fritillaria thunbergii cross the spin vibration sieve of 60 mesh sieves of installation, and evodia rutaecarpa crosses the spin vibration sieve of 50 mesh sieves of installation, the coptis, bamboo
Eat, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali cross the spin vibration sieve of installation 100-120 mesh sieves, the root of herbaceous peony crosses the spin vibration sieve for installing 200-260 mesh sieves, whole medicines
Material is crushed until by providing mesh number screen cloth.
3. dispensing is always mixed
First by cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony first by cuttlebone, fritillaria thunbergii
Mixing 5 minutes, is mixed 15 minutes after adding Oleum Citri Reticulatae.After the completion of mixing, taking-up powder is contained in closed in clean container.
4. capsule charge
Get through examining qualified total mixture to capsule filler to carry out capsule charge, content is in 0.5g, control
In the range of ± 10%, speed control is set as weighing once for every 15 minutes content uniformity.The capsule filled is polished
Processing, it is 18 revs/min to control polishing machine rotating speed.
5. aluminium-plastic bubble plate packing
The capsule of polishing is placed in blister packaging machine and carries out aluminium-plastic bubble plate packing, heat-sealing temperature is controlled 190
In the range of ± 20 DEG C, plastic uptake voltage is controlled in the range of 190 ± 20v, vacuum 0.09Mpa.
6. outer packing
Outer packing will be carried out through the good capsule of aluminium-plastic bubble plate packing, packing specification be the box of 10/plate × 4 plates/box × 100/
Case.A specification is put in each box；A work certificate, batch inspection report are put in each case (part)；Each case
(part) is packed with two straps, is packed with fastener for bundling articles；Lot number, date of manufacture, the term of validity on box, carton is by batch packaging directive
Print that errorless, position is correctly clear；Mounted box, packing number are accurate；The lot number of filled two batches product is stamped on case.
The product quality of embodiment 3 and quality
Unio margarita capsule intermediate products quality standard
Unio margarita capsule finished product quality standard：
The application of the Unio margarita capsule of embodiment 4
To verify the good effect of Unio margarita capsule of the present invention, inventor has carried out substantial amounts of experiment, suitable for inventor
After the patient of surrounding area where residence, good effect have received.According to the situation for accepting patient for medical treatment, it is summarized as follows：Accept for medical treatment
Patient totally 120, between 18-50 year, wherein male 58, women 62.
Existing selected section clinical experiment report is as follows：
1. diagnosis and treatment evaluation criteria
Recovery from illness：Clinical symptom disappearance, be discontinued half a year no relapse.
Effectively：Symptom mitigation, but do not take a turn for the better completely.
It is invalid：Symptom changes without obvious.
2. Syndrome Differentiation of Traditional Chinese Medicine, doctor trained in Western medicine examines diagnostic result.
3. pharmaceutical procedures：The dosage of the present invention depends on the factors such as patient age, body weight and health status.Therefore specific use
Amount needs the actual conditions such as the pathological characters according to patient, the specific cause of disease, because disease treats.
As medication guide, cuttlebone is taken (to shell) 55-70g, fritillaria thunbergii 8-15g, Oleum Citri Reticulatae 0.1-0.15g, evodia rutaecarpa
3-7g, coptis 2-4g, caulis bambusae in taenian 2-3g, prepared RHIZOMA PINELLIZE without adju-vant 1.5-2g, Radix Astragali 1-3g and root of herbaceous peony 2-2.5g, according to the preparation side of Unio margarita capsule
Method is taken after preparing into capsule, once in the morning and once at night.
Preferably, the amount of each component is：Cuttlebone (is shelled) 63g, fritillaria thunbergii 11g, Oleum Citri Reticulatae 0.12g, evodia rutaecarpa 5g, Huang
Even 3g, caulis bambusae in taenian 2.5g, prepared RHIZOMA PINELLIZE without adju-vant 1.6g, Radix Astragali 2g, root of herbaceous peony 2.4g.
4. clinical data collects：
From the above results, the Unio margarita capsule that prepared by the application shows to the therapeutic effect of gastric ulcer and duodenal ulcer
Write, especially effective up to 88% (herein, effective including recovery from illness and effective) to duodenal ulcer.
Model case is chosen below to illustrate：
Model case 1：Sun, man, 41 years old, upper abdomen was in distending pain after meal, sour regurgitation, to examination in hospital after be diagnosed as stomach and burst
Ulcer.Through using following Chinese medicine preparations：
Cuttlebone (peeling) 55g, fritillaria thunbergii 15g, Oleum Citri Reticulatae 0.15g, evodia rutaecarpa 3g, coptis 2g, caulis bambusae in taenian 3g, prepared RHIZOMA PINELLIZE without adju-vant
1.5g, Radix Astragali 3g and root of herbaceous peony 2g.Preparation method according to Unio margarita capsule is taken after being prepared into capsule, once in the morning and once at night.
Take medicine after two weeks, patient pain's symptom is gradually alleviated；After two months, pain symptom disappears, and does not recur again.
Model case 2：Mr. Wang, female, 53 years old, there is upper abdomen severe pain in early postprandial 1-3 hours, and rear midnight often wakes up, arrived bitterly
Duodenal ulcer is diagnosed as after examination in hospital.Through using following Chinese medicine preparations：
Cuttlebone (is shelled) 63g, fritillaria thunbergii 11g, Oleum Citri Reticulatae 0.12g, evodia rutaecarpa 5g, coptis 3g, caulis bambusae in taenian 2.5g, prepared RHIZOMA PINELLIZE without adju-vant
1.6g, Radix Astragali 2g and root of herbaceous peony 2.4g, take, once in the morning and once at night after being prepared into capsule according to the preparation method of Unio margarita capsule.
Take medicine after January, the postprandial pain symptom of patient is gradually alleviated；After two months, the awake frequency of pain at midnight is gradually less；Three
After individual month, all symptoms disappear, and do not recur again.
Finally illustrate, the above embodiments are merely illustrative of the technical solutions of the present invention and it is unrestricted, this area it is general
It is logical it will be appreciated by the skilled person that can be modified to technical scheme or equivalent substitution, without departing from technical solution of the present invention
Objective and scope, it all should cover among scope of the presently claimed invention.
Claims (11)
1. a kind of Unio margarita capsule for being used to treat gastric and duodenal ulcer, it is characterised in that be made up of following components：55-70
The cuttlebone of mass parts, the fritillaria thunbergii of 8-15 mass parts, the Oleum Citri Reticulatae of 0.1-0.15 mass parts, the evodia rutaecarpa of 3-7 mass parts, 2-
The coptis of 4 mass parts, the caulis bambusae in taenian of 2-3 mass parts, the prepared RHIZOMA PINELLIZE without adju-vant of 1.5-2 mass parts, the Radix Astragali of 1-3 mass parts and 2-2.5 mass
The root of herbaceous peony of part；The cuttlebone is shelled；
The preparation method of the Unio margarita capsule, specifically includes following steps：
A. cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony of above-mentioned parts by weight is taken to obtain composition A,
The Oleum Citri Reticulatae of above-mentioned parts by weight is taken to obtain compound B；
B. composition A described in step A is placed in mixer and mixed, mixed after adding compound B, used after well mixed
Capsule filler carries out capsule charge；
C. step B resulting articles are processed by shot blasting in capsule polisher.
2. Unio margarita capsule according to claim 1, it is characterised in that：It is made up of following components：The cuttlebone of 63 mass parts,
The fritillaria thunbergii of 11 mass parts, the Oleum Citri Reticulatae of 0.12 mass parts, the evodia rutaecarpa of 5 mass parts, the coptis of 3 mass parts, 2.5 mass parts
Caulis bambusae in taenian, the prepared RHIZOMA PINELLIZE without adju-vant of 1.6 mass parts, the root of herbaceous peony of the Radix Astragali of 2 mass parts and 2.4 mass parts.
3. Unio margarita capsule according to claim 1 or 2, it is characterised in that the pre-treatment step in step A is：To combination
Thing A sterilized, pulverize and sieve handle cuttlebone powder, bulb of thunberg fritillary female powder, evodiae powder, coptis powder, caulis bambusae in taenian powder, prepared RHIZOMA PINELLIZE without adju-vant powder,
Astragalus membranaceus powder, herbaceous peony powder.
4. Unio margarita capsule according to claim 1 or 2, it is characterised in that the preparation method of the Unio margarita capsule also includes
Following steps：
D. powder will be always mixed obtained by step B to be placed in capsule charge room, is encapsulated with Capsules, then packaged capsule is placed in bubble
In cover packing machine, packed with aluminum-plastic blister, you can obtain Unio margarita capsule.
5. Unio margarita capsule according to claim 1, it is characterised in that：Cuttlebone, fritillaria thunbergii, evodia rutaecarpa, the coptis, caulis bambusae in taenian,
Prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali, the root of herbaceous peony are crushed with Highefficientpulverizer, the material after crushing, and the rotation that cuttlebone, fritillaria thunbergii cross 60 mesh sieves of installation is shaken
Sieve, evodia rutaecarpa cross installation 50 mesh sieves spin vibration sieve, the coptis, caulis bambusae in taenian, prepared RHIZOMA PINELLIZE without adju-vant, the Radix Astragali cross installation 100-120 mesh sieves spin vibration sieve,
The root of herbaceous peony crosses the spin vibration sieve of installation 200-260 mesh sieves, and whole pulverizing medicinal materials are until by providing mesh number screen cloth.
6. Unio margarita capsule according to claim 3, it is characterised in that：The cuttlebone powder, bulb of thunberg fritillary female powder, evodiae powder,
Coptis powder, caulis bambusae in taenian powder, prepared RHIZOMA PINELLIZE without adju-vant powder, astragalus membranaceus powder, the bacterium of herbaceous peony powder cannot be greater than 5000, mould saccharomycete cannot be greater than 50
It is individual.
7. the Unio margarita capsule described in claim 1 or 2, it is characterised in that：The disintegration time limited of the Unio margarita capsule cannot be greater than 30
Minute.
8. the Unio margarita capsule described in claim 3, it is characterised in that：The disintegration time limited of the Unio margarita capsule cannot be greater than 30 points
Clock.
9. the Unio margarita capsule described in claim 4, it is characterised in that：The disintegration time limited of the Unio margarita capsule cannot be greater than 30 points
Clock.
10. the Unio margarita capsule described in claim 5 or 6, it is characterised in that：The disintegration time limited of the Unio margarita capsule cannot be greater than 30
Minute.
11. the Unio margarita capsule of claim 6 is preparing the application in being used to treat the medicine of gastric and duodenal ulcer.
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| CN201510495802.9A CN105031354B (en) | 2015-08-13 | 2015-08-13 | Unio margarita capsule for treating gastroduodenal ulcer and its preparation method and application |
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| CN105031354B true CN105031354B (en) | 2018-03-30 |
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| CN114404387A (en) * | 2022-01-18 | 2022-04-29 | 重庆多普泰制药股份有限公司 | A Bulbus Fritillariae Cirrhosae granule and its preparation method |
Citations (4)
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|---|---|---|---|---|
| CN1365747A (en) * | 2001-01-19 | 2002-08-28 | 杨孟君 | Nano medicine 'Wubei' and its preparing process |
| CN1572309A (en) * | 2003-06-05 | 2005-02-02 | 丁永芳 | Novel Chinese traditional medicine preparation of WuBei Powder for suspension and its preparation method |
| CN101695556A (en) * | 2009-10-22 | 2010-04-21 | 黄向明 | Chinese medicinal electuary for treating gastralgia and preparation method thereof |
| CN104510999A (en) * | 2013-10-07 | 2015-04-15 | 青岛联合创新技术服务平台有限公司 | Traditional Chinese medicines formula for treating chronic gastritis |
-
2015
- 2015-08-13 CN CN201510495802.9A patent/CN105031354B/en active Active
Patent Citations (4)
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|---|---|---|---|---|
| CN1365747A (en) * | 2001-01-19 | 2002-08-28 | 杨孟君 | Nano medicine 'Wubei' and its preparing process |
| CN1572309A (en) * | 2003-06-05 | 2005-02-02 | 丁永芳 | Novel Chinese traditional medicine preparation of WuBei Powder for suspension and its preparation method |
| CN101695556A (en) * | 2009-10-22 | 2010-04-21 | 黄向明 | Chinese medicinal electuary for treating gastralgia and preparation method thereof |
| CN104510999A (en) * | 2013-10-07 | 2015-04-15 | 青岛联合创新技术服务平台有限公司 | Traditional Chinese medicines formula for treating chronic gastritis |
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| 中医药治疗消化性溃疡研究近况;贺俭;《中医药信息》;19980710(第04期);第14页 * |
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