CN105031179A - Tablet for treating fever and preparation method thereof - Google Patents
Tablet for treating fever and preparation method thereof Download PDFInfo
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- CN105031179A CN105031179A CN201510481304.9A CN201510481304A CN105031179A CN 105031179 A CN105031179 A CN 105031179A CN 201510481304 A CN201510481304 A CN 201510481304A CN 105031179 A CN105031179 A CN 105031179A
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Abstract
The invention discloses a tablet for treating fever and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine preparation. The tablet comprises starch, gypsum, crystal sugar, honey, magnesium stearate and a traditional Chinese medicine preparation. The tablet is prepared through the steps of crude product preparing, drying, sterilizing and the like. The tablet integrates the effects of multiple traditional Chinese medicines and can achieve the effects of resisting bacteria, eliminating inflammation, dispelling wind and heat, clearing heat, removing toxicity and the like, and the total effective rate reaches 96.79 percent through clinical tests on 156 headache patients; the tablet is significant in treatment effect, rapid to take the effects and free of side effects, and can be applied and popularized in clinic.
Description
[technical field]
The invention belongs to Chinese drug preparation technique field, be specifically related to a kind of tablet for the treatment of heating and preparation method thereof.
[background technology]
Heating is because the body temperature that human body heat production is too much and heat radiation deficiency causes is higher than normal symptom.Cause the cause of disease of heating a lot, clinical modal be caused by infected by microbes, noninfective some diseases such as tumor, hyperthyroidism, rheumatological disease and autonomic nervous dysfunction also have heating.The traditional Chinese medical science is classified heating traditionally according to fever caused by exogenous pathogens and fever due to internal injury, exterior syndrome has heresy, and how empty internal injury is, and the stagnation of QI of often holding concurrently, blood stasis, phlegm retention, water wet as suffering from, and lay particular stress on, each An Qizhi with it.Heating brings great misery not only to numerous patients, and seriously affects quality of life and the health of this disease patient.Therefore, necessary research and development are a kind of is used for the treatment of the medicine that heating is evident in efficacy, rapid-action, have no side effect.
[summary of the invention]
The invention provides a kind of tablet for the treatment of heating and preparation method thereof, to solve the problems such as treatment therapeutic fever heterodyne, onset be slow, the present invention combines plurality of Chinese effect, the effects such as anti-inflammation, dispelling wind and heat pathogens, heat-clearing and toxic substances removing can be played, this tablet is evident in efficacy, rapid-action, have no side effect, and clinically can apply.
For solving above technical problem, the present invention by the following technical solutions:
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 400-1600 part, Gypsum Fibrosum 100-600 part, crystal sugar 100-300 part, Mel 100-300 part, magnesium stearate 100-300 part, Chinese medicine preparation 100-400 part, described Chinese medicine preparation comprises following raw material: Radix Paeoniae Alba 8-32 part, Radix Angelicae Sinensis 8-32 part, Radix Puerariae 8-32 part, Fructus Arctii 8-32 part, Rhizoma Coptidis 8-32 part, Pericarpium Citri Reticulatae 6-24 part, Poria 6-24 part, Herba Taraxaci 6-24 part, Radix Paeoniae Rubra 6-24 part, Rhizoma Acori Graminei 6-24 part, Radix Bupleuri 4-16 part, Herba Schizonepetae 4-16 part, Ramulus Cinnamomi 4-16 part, Rhizoma Anemarrhenae 4-16 part, Flos Lonicerae 4-16 part, Herba Houttuyniae 2-8 part, Herba Leonuri 2-8 part, Radix Glycyrrhizae 2-8 part, Folium Perillae 2-8 part, Folium Artemisiae Argyi 2-8 part.
Preferably, the tablet of described treatment heating, in units of weight portion, comprise following raw material: starch 600-1400 part, Gypsum Fibrosum 200-500 part, crystal sugar 150-250 part, Mel 150-250 part, magnesium stearate 150-250 part, Chinese medicine preparation 150-350 part, described Chinese medicine preparation comprises following raw material: Radix Paeoniae Alba 12-28 part, Radix Angelicae Sinensis 12-28 part, Radix Puerariae 12-28 part, Fructus Arctii 12-28 part, Rhizoma Coptidis 12-28 part, Pericarpium Citri Reticulatae 9-21 part, Poria 9-21 part, Herba Taraxaci 9-21 part, Radix Paeoniae Rubra 9-21 part, Rhizoma Acori Graminei 9-21 part, Radix Bupleuri 6-14 part, Herba Schizonepetae 6-14 part, Ramulus Cinnamomi 6-14 part, Rhizoma Anemarrhenae 6-14 part, Flos Lonicerae 6-14 part, Herba Houttuyniae 3-7 part, Herba Leonuri 3-7 part, Radix Glycyrrhizae 3-7 part, Folium Perillae 3-7 part, Folium Artemisiae Argyi 3-7 part.
Preferably, the tablet of described treatment heating, in units of weight portion, comprise following raw material: starch 1000 parts, 350 parts, Gypsum Fibrosum, 200 parts, crystal sugar, Mel 200 parts, magnesium stearate 200 parts, Chinese medicine preparation 250 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 20 parts, Radix Angelicae Sinensis 20 parts, Radix Puerariae 20 parts, Fructus Arctii 20 parts, Rhizoma Coptidis 20 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Poria, Herba Taraxaci 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Acori Graminei 15 parts, Radix Bupleuri 10 parts, Herba Schizonepetae 10 parts, Ramulus Cinnamomi 10 parts, the Rhizoma Anemarrhenae 10 parts, Flos Lonicerae 10 parts, Herba Houttuyniae 5 parts, Herba Leonuri 5 parts, 5 parts, Radix Glycyrrhizae, Folium Perillae 5 parts, Folium Artemisiae Argyi 5 parts.
The present invention also provides a kind of preparation method for the treatment of the tablet of heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200-1000 part water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: the tablet crude product of the treatment heating that step S1 is obtained is dried, after sterilizing, the tablet of obtained treatment heating.
Preferably, the temperature of drying in step S2 is 80-100 DEG C, dries to water content≤6%, and the pressure of sterilizing is 210-230KPa, and the temperature of sterilizing is 134-136 DEG C, and the time of sterilizing is 6-8min.
Preferably, the preparation method of Chinese medicine preparation described in step S1 comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8-16, ultrasonic power is 120-180W, concentration of alcohol is 50%-80%, Extracting temperature is 40-70 DEG C, and extraction time is 30-90min;
S12: the medical filtration obtained by step S11, be condensed into paste;
S13: the paste of step S12 dried, pulverizes, sieve, sterilizing, obtained described Chinese medicine preparation.
Preferably, in step S12, the water content of paste is 40%-50%.
Preferably, the condition of drying in step S13 is: dry to water content≤6% at 90-105 DEG C.
Preferably, the condition of sieving in step S13 is: cross 200-400 object sieve.
Preferably, in step S13, the condition of sterilizing is: temperature is 134-136 DEG C, and pressure is 210-230KPa, and the time is 4-6min.
Chinese medicine preparation pharmacology of the present invention is as follows:
The Radix Paeoniae Alba has suppressing liver-YANG, nourishes blood and receives the effects such as cloudy, can control the symptoms such as headache, dizzy, heating.
Radix Angelicae Sinensis has benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes the effects such as laxation, cure mainly that menoxenia, amenorrhea stomachache, lump in the abdomen knot are poly-, metrorrhagia, headache due to deficiency of blood, dizzy, heating, the disease such as flaccidity syndrome and arthralgia syndrome.
Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, deliver examine, the effect such as promoting the production of body fluid to quench thirst, yang invigorating antidiarrheal, fever caused by exogenous pathogens can be controlled, rigidity pain on the head and nape, measles go out the symptoms such as smooth, epidemic febrile disease is thirsty, diabetes from the beginning of, rash.
Fructus Arctii has the effect such as heat of dispeling the wind, detumescence poison, can control that pathogenic wind toxic swelling of the face, dizziness, heating, throat heat are swollen, toothache, cough, the symptom such as to quench one's thirst.
Rhizoma Coptidis has the effect such as heat clearing and damp drying, eliminating fire and detoxication, can control the symptoms such as damp and hot, feeling of fullness, vomiting, dysentery, jaundice, unconsciousness due to high fever, heating.
Pericarpium Citri Reticulatae has effect such as spleen invigorating, drying dampness to eliminate phlegm, the greasy lasting of solution, stopping nausea and vomiting by lowering the adverse flow of QI of ventilation, can control the symptoms such as cough heating, distension and fullness of the chest and abdomen, anorexia, vomiting hiccup, cough with copious phlegm.
Poria has the effects such as eliminating dampness and diuresis, invigorating the spleen and regulating the stomach, mind tranquilizing and the heart calming, dysuria, edema distension, heating, phlegm retention cough with dyspnea, vomiting, malignant histocytosis can be controlled, have loose bowels, pass out semen, stranguria with turbid discharge, palpitation with fear, the symptom such as forgetful.
Herba Taraxaci has the effects such as heat-clearing and toxic substances removing, eliminating carbuncle eliminating stagnation, antiinflammatory, removing heat from blood, diuresis, function of gallbladder promoting, can the symptom such as the hot conjunctival congestion and swelling pain for the treatment of the liver, purulent disease.
Radix Paeoniae Rubra has the effect such as clearing away heat and cooling blood, promoting blood circulation to remove blood stasis, can control the diseases such as headache, menoxenia, heating, spontaneous sweating, conjunctival congestion and swelling pain, stomachache, hypochondriac pain.
Rhizoma Acori Graminei has waking up the patient from unconsciousness by dissipating phlegm, removing dampness circulation of qi promoting, effects such as sharp numbness, reducing swelling and alleviating pain of dispeling the wind, and can control the diseases such as calentura coma, syncope due to accumulation of phlegm, forgetful, tinnitus, deafness, abdominal distention, fasting dysentery, rheumatic arthralgia, heating, traumatic injury.
Radix Bupleuri have induce sweat bring down a fever, the effect such as dispersing the stagnated live-QI to relieve the stagnation of QI, elevate a turnable ladder yang-energy, the diseases such as fever caused by exogenous pathogens, alternate attack of chill and fever, malaria, hypochondriac pain due to stagnation of liverQI, mammary swelling, headache, dizziness can be controlled.
The effects such as Herba Schizonepetae has dispeling the wind, induces sweat, rash, hemostasis, can cure cold the diseases such as heating, headache, eye itching, cough, laryngopharynx swelling and pain.
Ramulus Cinnamomi has expelling cold and relieving exterior syndrome, help heart-yang and, the effect such as resolving fluid-retention with drugs of warm nature, the symptoms such as anemofrigid cold, harmonizing yingfen and weifen, expelling pathogenic factors from muscles hidroschesis can be controlled.
The effects such as the Rhizoma Anemarrhenae has resolving heat and reducing pathogenic fire, nourshing Yin and drynsessmoistening prescription, can control epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, the symptoms such as stranguria with turbid discharge of quenching one's thirst.
Flos Lonicerae has the effect such as heat-clearing and toxic substances removing, dispelling wind and heat pathogens, cures mainly red and swollen heat pain, affection due to external wind and heat, epidemic febrile disease from the beginning of, the symptom such as toxic-heat and blood stasis, summer-heat excessive thirst, laryngopharynx swelling and pain.
Herba Houttuyniae has the effect such as heat-clearing and toxic substances removing, inducing diuresis to remove edema, can cure cold, generate heat, pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, the symptom such as leucorrhea.
Herba Leonuri has the effects such as promoting blood flow to regulate menstruation, heat-clearing and toxic substances removing, inducing diuresis to remove edema, can control heating, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rush down the symptom such as blood, carbuncle skin infection.
Radix Glycyrrhizae has removing toxic substances, eliminates the phlegm, pain relieving, spasmolytic, the effect such as anticancer, can cure cold, have a fever, have a headache, cough, cardio palmus shape.
Folium Perillae has the effect such as expelling cold and relieving exterior syndrome, regulating the flow of QI to ease the stomach, cures mainly the symptoms such as anemofrigid cold, headache, fever, cough, distension and fullness of the chest and abdomen.
Folium Artemisiae Argyi has warming the meridian, dries, cold expelling, hemostasis, antiinflammatory, relieving asthma, cough-relieving, the effect such as antiabortive, antiallergic, heating, trusted subordinate's cold type of pain can be controlled, convulsion of having loose bowels, chronic dysentery, tell the symptoms such as nosebleed, hematochezia, menoxenia, metrorrhagia.
The present invention has following beneficial effect:
(1) the present invention combines the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi plurality of Chinese effect, the effects such as anti-inflammation, dispelling wind and heat pathogens, heat-clearing and toxic substances removing can be played, warp is to 156 routine headache clinical trials, total effective rate reaches 96.79%, this curative effect of medication is remarkable, rapid-action, have no side effect, and clinically can apply;
(2) tablet of the present invention carries out sterilizing at high temperature under high pressure, and the time is short, effective, the holding time is long;
(3) tablet manufacturing method of the present invention is simple to operate, and production cost is low, is conducive to applying.
[detailed description of the invention]
Be specifically described below in conjunction with specific embodiment.
Embodiment 1
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 1000 parts, 350 parts, Gypsum Fibrosum, 200 parts, crystal sugar, Mel 200 parts, magnesium stearate 200 parts, Chinese medicine preparation 250 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 20 parts, Radix Angelicae Sinensis 20 parts, Radix Puerariae 20 parts, Fructus Arctii 20 parts, Rhizoma Coptidis 20 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Poria, Herba Taraxaci 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Acori Graminei 15 parts, Radix Bupleuri 10 parts, Herba Schizonepetae 10 parts, Ramulus Cinnamomi 10 parts, the Rhizoma Anemarrhenae 10 parts, Flos Lonicerae 10 parts, Herba Houttuyniae 5 parts, Herba Leonuri 5 parts, 5 parts, Radix Glycyrrhizae, Folium Perillae 5 parts, Folium Artemisiae Argyi 5 parts.
The preparation method of the tablet of described treatment heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 600 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: it is 6% that the tablet crude product that the treatment that step S1 obtains is generated heat is dried to water content at temperature is 80 DEG C, and be 210KPa at pressure, temperature is 134 DEG C, and the time is under 8min after sterilizing, the tablet of obtained treatment heating.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:12, ultrasonic power is 160W, concentration of alcohol is 60%, Extracting temperature is 50 DEG C, and extraction time is 30min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 40%;
S13: being dried by the paste of step S12 to water content at 105 DEG C is 4%, crosses 300 object sieves after pulverizing, be finally 136 DEG C the powder of the gained that sieves in temperature, pressure is 30KPa, and the time is sterilizing under 4min, obtained medicine preparation.
Embodiment 2
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 400 parts, 100 parts, Gypsum Fibrosum, 100 parts, crystal sugar, Mel 100 parts, magnesium stearate 100 parts, Chinese medicine preparation 100 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 8 parts, Radix Angelicae Sinensis 8 parts, Radix Puerariae 8 parts, Fructus Arctii 8 parts, Rhizoma Coptidis 8 parts, Pericarpium Citri Reticulatae 6 parts, 6 parts, Poria, Herba Taraxaci 6 parts, Radix Paeoniae Rubra 6 parts, Rhizoma Acori Graminei 6 parts, Radix Bupleuri 4 parts, Herba Schizonepetae 4 parts, Ramulus Cinnamomi 4 parts, the Rhizoma Anemarrhenae 4 parts, Flos Lonicerae 4 parts, Herba Houttuyniae 2 parts, Herba Leonuri 2 parts, 2 parts, Radix Glycyrrhizae, Folium Perillae 2 parts, Folium Artemisiae Argyi 2 parts.
The preparation method of the tablet of described treatment heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: it is 5% that the tablet crude product that the treatment that step S1 obtains is generated heat is dried to water content at temperature is 100 DEG C, and be 230KPa at pressure, temperature is 136 DEG C, and the time is under 6min after sterilizing, the tablet of obtained treatment heating.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8, ultrasonic power is 120W, concentration of alcohol is 50%, Extracting temperature is 40 DEG C, and extraction time is 90min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 50%;
S13: being dried by the paste of step S12 to water content at 90 DEG C is 6%, crosses 200 object sieves after pulverizing, be finally 134 DEG C the powder of the gained that sieves in temperature, pressure is 210KPa, and the time is sterilizing under 6min, obtained Chinese medicine preparation.
Embodiment 3
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 1600 parts, 600 parts, Gypsum Fibrosum, 300 parts, crystal sugar, Mel 300 parts, magnesium stearate 300 parts, Chinese medicine preparation 400 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 32 parts, Radix Angelicae Sinensis 32 parts, Radix Puerariae 32 parts, Fructus Arctii 32 parts, Rhizoma Coptidis 32 parts, Pericarpium Citri Reticulatae 24 parts, 24 parts, Poria, Herba Taraxaci 24 parts, Radix Paeoniae Rubra 24 parts, Rhizoma Acori Graminei 24 parts, Radix Bupleuri 16 parts, Herba Schizonepetae 16 parts, Ramulus Cinnamomi 16 parts, the Rhizoma Anemarrhenae 16 parts, Flos Lonicerae 16 parts, Herba Houttuyniae 8 parts, Herba Leonuri 8 parts, 8 parts, Radix Glycyrrhizae, Folium Perillae 8 parts, Folium Artemisiae Argyi 8 parts.
The preparation method of the tablet of described treatment heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 1000 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: it is 4% that the tablet crude product that the treatment that step S1 obtains is generated heat is dried to water content at temperature is 90 DEG C, and be 220KPa at pressure, temperature is 135 DEG C, and the time is under 7min after sterilizing, the tablet of obtained treatment heating.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:16, ultrasonic power is 180W, concentration of alcohol is 80%, Extracting temperature is 70 DEG C, and extraction time is 50min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 45%;
S13: being dried by the paste of step S12 to water content at 100 DEG C is 5%, crosses 400 object sieves after pulverizing, be finally 135 DEG C the powder of the gained that sieves in temperature, pressure is 220KPa, and the time is sterilizing under 5min, obtained Chinese medicine preparation.
Embodiment 4
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 600 parts, 200 parts, Gypsum Fibrosum, 150 parts, crystal sugar, Mel 150 parts, magnesium stearate 150 parts, Chinese medicine preparation 150 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 12 parts, Radix Angelicae Sinensis 12 parts, Radix Puerariae 12 parts, Fructus Arctii 12 parts, Rhizoma Coptidis 12 parts, Pericarpium Citri Reticulatae 9 parts, 9 parts, Poria, Herba Taraxaci 9 parts, Radix Paeoniae Rubra 9 parts, Rhizoma Acori Graminei 9 parts, Radix Bupleuri 6 parts, Herba Schizonepetae 6 parts, Ramulus Cinnamomi 6 parts, the Rhizoma Anemarrhenae 6 parts, Flos Lonicerae 6 parts, Herba Houttuyniae 3 parts, Herba Leonuri 3 parts, 3 parts, Radix Glycyrrhizae, Folium Perillae 3 parts, Folium Artemisiae Argyi 3 parts.
The preparation method of the tablet of described treatment heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 500 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: it is 6% that the tablet crude product that the treatment that step S1 obtains is generated heat is dried to water content at temperature is 80 DEG C, and be 210KPa at pressure, temperature is 134 DEG C, and the time is under 8min after sterilizing, the tablet of obtained treatment heating.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:10, ultrasonic power is 140W, concentration of alcohol is 70%, Extracting temperature is 60 DEG C, and extraction time is 70min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 43%;
S13: being dried by the paste of step S12 to water content at 95 DEG C is 6%, crosses 200 object sieves after pulverizing, be finally 134 DEG C the powder of the gained that sieves in temperature, pressure is 210KPa, and the time is sterilizing under 6min, obtained Chinese medicine preparation.
Embodiment 5
A kind of tablet for the treatment of heating, in units of weight portion, comprise following raw material: starch 1400 parts, 500 parts, Gypsum Fibrosum, 250 parts, crystal sugar, Mel 250 parts, magnesium stearate 250 parts, Chinese medicine preparation 350 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 28 parts, Radix Angelicae Sinensis 28 parts, Radix Puerariae 28 parts, Fructus Arctii 28 parts, Rhizoma Coptidis 28 parts, Pericarpium Citri Reticulatae 21 parts, 21 parts, Poria, Herba Taraxaci 21 parts, Radix Paeoniae Rubra 21 parts, Rhizoma Acori Graminei 21 parts, Radix Bupleuri 14 parts, Herba Schizonepetae 14 parts, Ramulus Cinnamomi 14 parts, the Rhizoma Anemarrhenae 14 parts, Flos Lonicerae 14 parts, Herba Houttuyniae 7 parts, Herba Leonuri 7 parts, 7 parts, Radix Glycyrrhizae, Folium Perillae 7 parts, Folium Artemisiae Argyi 7 parts.
The preparation method of the tablet of described treatment heating, comprises the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 800 parts of water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: it is 5% that the tablet crude product that the treatment that step S1 obtains is generated heat is dried to water content at temperature is 100 DEG C, and be 230KPa at pressure, temperature is 136 DEG C, and the time is under 6min after sterilizing, the tablet of obtained treatment heating.
The preparation method of above-mentioned Chinese medicine preparation, comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:14, ultrasonic power is 150W, concentration of alcohol is 50%, Extracting temperature is 60 DEG C, and extraction time is 60min;
S12: the medical filtration obtained by step S11, to be condensed into paste water content be 48%;
S13: being dried by the paste of step S12 to water content at 105 DEG C is 5%, crosses 400 object sieves after pulverizing, be finally 136 DEG C the powder of the gained that sieves in temperature, pressure is 230KPa, and the time is sterilizing under 4min, obtained Chinese medicine preparation.
As follows through clinical test results: treatment fever patient 156 example, male 80 example, women 76 example, the age be 12-83 year, usage is: the tablet taking embodiment 1, every day three times, be 1-3 sheet g, consumption takes the circumstances into consideration to add and subtract dosage according to the concrete condition of patient at every turn, it within two days, is a course for the treatment of, take observe the curative effect after two courses for the treatment of, recovery from illness 132 example, accounts for 84.62%; Effective 11 examples, account for 7.05%; Take a turn for the better 8 examples, accounts for 5.13%; Invalid 5 examples, account for 3.21%; Total effective rate reaches 96.79%, and after two course of therapy, the shapes such as patient's heating, headache all have clear improvement or fully recover, and patient is without any untoward reaction.
Above content can not assert that the present invention specifically implements to be confined to these explanations; for general technical staff of the technical field of the invention; do not departing under concept thereof of the present invention; some simple deduction or replace can also be made, all should be considered as belonging to the scope of patent protection that the present invention is determined by submitted to claims.
Claims (10)
1. treat the tablet of heating for one kind, it is characterized in that, in units of weight portion, comprise following raw material: starch 400-1600 part, Gypsum Fibrosum 100-600 part, crystal sugar 100-300 part, Mel 100-300 part, magnesium stearate 100-300 part, Chinese medicine preparation 100-400 part, described Chinese medicine preparation comprises following raw material: Radix Paeoniae Alba 8-32 part, Radix Angelicae Sinensis 8-32 part, Radix Puerariae 8-32 part, Fructus Arctii 8-32 part, Rhizoma Coptidis 8-32 part, Pericarpium Citri Reticulatae 6-24 part, Poria 6-24 part, Herba Taraxaci 6-24 part, Radix Paeoniae Rubra 6-24 part, Rhizoma Acori Graminei 6-24 part, Radix Bupleuri 4-16 part, Herba Schizonepetae 4-16 part, Ramulus Cinnamomi 4-16 part, Rhizoma Anemarrhenae 4-16 part, Flos Lonicerae 4-16 part, Herba Houttuyniae 2-8 part, Herba Leonuri 2-8 part, Radix Glycyrrhizae 2-8 part, Folium Perillae 2-8 part, Folium Artemisiae Argyi 2-8 part.
2. the tablet for the treatment of heating according to claim 1, it is characterized in that, in units of weight portion, comprise following raw material: starch 600-1400 part, Gypsum Fibrosum 200-500 part, crystal sugar 150-250 part, Mel 150-250 part, magnesium stearate 150-250 part, Chinese medicine preparation 150-350 part, described Chinese medicine preparation comprises following raw material: Radix Paeoniae Alba 12-28 part, Radix Angelicae Sinensis 12-28 part, Radix Puerariae 12-28 part, Fructus Arctii 12-28 part, Rhizoma Coptidis 12-28 part, Pericarpium Citri Reticulatae 9-21 part, Poria 9-21 part, Herba Taraxaci 9-21 part, Radix Paeoniae Rubra 9-21 part, Rhizoma Acori Graminei 9-21 part, Radix Bupleuri 6-14 part, Herba Schizonepetae 6-14 part, Ramulus Cinnamomi 6-14 part, Rhizoma Anemarrhenae 6-14 part, Flos Lonicerae 6-14 part, Herba Houttuyniae 3-7 part, Herba Leonuri 3-7 part, Radix Glycyrrhizae 3-7 part, Folium Perillae 3-7 part, Folium Artemisiae Argyi 3-7 part.
3. the tablet for the treatment of heating according to claim 2, it is characterized in that, in units of weight portion, comprise following raw material: starch 1000 parts, 350 parts, Gypsum Fibrosum, 200 parts, crystal sugar, Mel 200 parts, magnesium stearate 200 parts, Chinese medicine preparation 250 parts, described Chinese medicine preparation comprises following raw material: the Radix Paeoniae Alba 20 parts, Radix Angelicae Sinensis 20 parts, Radix Puerariae 20 parts, Fructus Arctii 20 parts, Rhizoma Coptidis 20 parts, Pericarpium Citri Reticulatae 15 parts, 15 parts, Poria, Herba Taraxaci 15 parts, Radix Paeoniae Rubra 15 parts, Rhizoma Acori Graminei 15 parts, Radix Bupleuri 10 parts, Herba Schizonepetae 10 parts, Ramulus Cinnamomi 10 parts, the Rhizoma Anemarrhenae 10 parts, Flos Lonicerae 10 parts, Herba Houttuyniae 5 parts, Herba Leonuri 5 parts, 5 parts, Radix Glycyrrhizae, Folium Perillae 5 parts, Folium Artemisiae Argyi 5 parts.
4. the preparation method of the tablet of the treatment heating according to any one of claim 1-3, is characterized in that, comprise the following steps:
S1, crude product are produced: starch, Gypsum Fibrosum, crystal sugar, Mel, magnesium stearate, Chinese medicine preparation mixing, add 200-1000 part water and make lamellar after stirring, the tablet crude product of obtained treatment heating;
S2, oven dry, sterilizing: the tablet crude product of the treatment heating that step S1 is obtained is dried, after sterilizing, the tablet of obtained treatment heating.
5. the preparation method of the tablet for the treatment of heating according to claim 4, it is characterized in that, the temperature of drying in step S2 is 80-100 DEG C, dry to water content≤6%, the pressure of sterilizing is 210-230KPa, and the temperature of sterilizing is 134-136 DEG C, and the time of sterilizing is 6-8min.
6. the preparation method of the tablet for the treatment of heating according to claim 4, it is characterized in that, the preparation method of Chinese medicine preparation described in step S1 comprises the following steps:
S11: the Radix Paeoniae Alba, Radix Angelicae Sinensis, Radix Puerariae, Fructus Arctii, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Poria, Herba Taraxaci, Radix Paeoniae Rubra, Rhizoma Acori Graminei, Radix Bupleuri, Herba Schizonepetae, Ramulus Cinnamomi, the Rhizoma Anemarrhenae, Flos Lonicerae, Herba Houttuyniae, Herba Leonuri, Radix Glycyrrhizae, Folium Perillae, Folium Artemisiae Argyi are extracted in ultrasonic assistant ethanol extraction FAXIA, obtain medicinal liquid, the condition extracted is: solid-liquid ratio is 1:8-16, ultrasonic power is 120-180W, concentration of alcohol is 50%-80%, Extracting temperature is 40-70 DEG C, and extraction time is 30-90min;
S12: the medical filtration obtained by step S11, be condensed into paste;
S13: the paste of step S12 dried, pulverizes, sieve, sterilizing, obtained described Chinese medicine preparation.
7. the preparation method of the tablet for the treatment of heating according to claim 6, it is characterized in that, in step S12, the water content of paste is 40%-50%.
8. the preparation method of the tablet for the treatment of heating according to claim 6, it is characterized in that, the condition of drying in step S13 is: dry to water content≤6% at 90-105 DEG C.
9. the preparation method of the tablet for the treatment of heating according to claim 6, it is characterized in that, the condition of sieving in step S13 is: cross 200-400 object sieve.
10. the preparation method of the tablet for the treatment of heating according to claim 6, it is characterized in that, in step S13, the condition of sterilizing is: temperature is 134-136 DEG C, and pressure is 210-230KPa, and the time is 4-6min.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872204A (en) * | 2006-04-24 | 2006-12-06 | 江西天施康中药股份有限公司 | Medication composition for treating neurasthenia, preparation technique, and method for testing quality |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1872204A (en) * | 2006-04-24 | 2006-12-06 | 江西天施康中药股份有限公司 | Medication composition for treating neurasthenia, preparation technique, and method for testing quality |
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| Title |
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| 张宝林等: "《中医儿科集成.第二集》", 31 July 2010, 中南大学出版社 * |
| 陶玉慧等: "外感热病病因、证治和方药的数据分析研究", 《中国民族民间医药》 * |
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