CN105031069A - Medicine for treating metroptosis and preparing method thereof - Google Patents
Medicine for treating metroptosis and preparing method thereof Download PDFInfo
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Abstract
The invention discloses medicine for treating the metroptosis and a preparing method thereof. The medicine is mainly prepared by astragalus membranaceus, bighead atractylodes rhizome, cimicifugae foetidae, radix bupleuri, ginseng, angelica sinensis, rosa laevigata and herba violae in a certain weight ratio. The medicine has the effects of reinforcing vital energy, carrying out astringing, promoting salivation and carrying out detoxication and tissue generation. When the medicine is used for treating the metroptosis, effect taking is rapid, the curative effect is good, and relapsing is avoided.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of uterine prolapse and preparation method thereof, belong to the field of Chinese medicines.
Background technology
Uterine prolapse refers to that uterus declines from normal position along vagina, and it is below horizontal that cervical orifice reaches ischial spine, and even uterus all emerges in beyond vaginal orifice, is called uterine prolapse, and uterine prolapse is often associated with anterior vaginal wall and rear wall bulging.Patient's leucorrhoea grow in quantity, and be pus sample or band blood sometimes, some generation menoxenias, menorrhagia.At present, because Western medicine effectively cannot treat uterine prolapse, therefore there is great demand in the Chinese medicine of people to effectively treatment uterine prolapse, up to now, also do not find about relevant report of the present invention.
Summary of the invention
The present inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, finally successfully have found the medicine of effectively treatment uterine prolapse, thus completes the present invention.
Object of the present invention is just to provide a kind of Chinese medicine composition of effective treatment uterine prolapse.
Another object of the present invention just there is provided the preparation method of this Chinese medicine composition.
Medicine of the present invention selects: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae medicine carry out combination preparation, made by these drug regimens each efficacy of drugs produce synergism, thus effectively can treat uterine prolapse.
Wherein select the Radix Astragali to be that tepor, enters lung, spleen channel because its nature and flavor are sweet, life defends consolidating superficial resistance with useful, inducing diuresis to remove edema, poison holding, and the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, and carbuncle is not burst or burst and holds back for a long time; Processing the function with there being invigorating middle warmer benefit, controlling internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select the Rhizoma Atractylodis Macrocephalae to be because its property bitter but sweet flavor, temperature, enters spleen, stomach warp, has spleen reinforcing, stomach reinforcing, dampness, and in function, control deficient QI of the spleen and stomach, anorexia, asthenia weak breath, deficiency-distension, has loose bowels, phlegm retention, edema, jaundice, arthralgia chiefly caused by damp pathogen, dysuria, dizzy, spontaneous perspiration, and nausea is uneasy.Pericarpium Citri Reticulatae is selected to be that temperature, return lung, spleen channel, have regulating qi-flowing for strengthening spleen, the function of drying dampness to eliminate phlegm, controls fullness in the epigastrium and chest, lack of appetite and vomiting, cough with copious phlegm because its nature and flavor are bitter, pungent.Rhizoma Cimicifugae is selected to be because the sweet pungent micro-hardship of its nature and flavor, cool, enter lung, spleen, stomach warp, have yang invigorating, deliver, rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, laryngalgia, aphtha scar, and macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus drops, carbuncle sore tumefacting virus.Select Radix Bupleuri to be that cool, enter liver, gallbladder meridian, have reconciling superficies and interior, soothing the liver, the function of yang invigorating, controls alternate attack of chill and fever, fullness in the chest and hypochondriac pain because its nature and flavor are bitter, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Radix Ginseng is selected to be that temperature, enters spleen, lung meridian, have strongly invigorating primordial QI because its nature and flavor are sweet micro-sweet, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, and empty cough with asthma is urged, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select Radix Glycyrrhizae to be because its nature and flavor are sweet flat, enter spleen, stomach, lung meridian, have and middle emergency, lung moistening, removing toxic substances, the function of coordinating the actions of various ingredients in a prescription, process with controlling weakness of the spleen and stomach, lack of appetite, stomachache loose stool, overstrain generates heat, and consumptive lung disease is coughed, cardiopalmus, frightened carbuncle, raw with controlling laryngopharynx swelling and pain, peptic ulcer, ulcer sores, separates poison of drug and alimentary toxicosis.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm, enter the heart, liver, spleen channel, enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize the function of laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood is dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty is just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Fructus Rosae Laevigatae is selected to be that flat, have reinforcing the kidney and controlling nocturnal emission, the function of reducing urination and antidiarrheal, controls spermatorrhea, the enuresis, frequent micturition, insufficiency of the spleen dysentery because its nature and flavor are sour and astringent.Herba Patriniae is selected to be that enter liver, stomach, large intestine channel, have heat-clearing and toxic substances removing, the function of evacuation of pus removing blood stasis with potent drugs, controls acute appendicitis, dysentery, leucorrhea with red and white discharge, the stagnant stomachache of the stasis of blood in puerperal, conjunctival congestion and swelling pain, carbuncle scabies because its nature and flavor hardship is flat.Select Herba Violae to be that GUIXIN, Liver Channel, have heat-clearing and toxic substances removing because its nature and flavor bitter, acrid, cold, the function of removing heat from blood detumescence, controls furuncle swelling toxin, carbuncle carbuncle on the back, erysipelas, venom.
Detailed description of the invention
The drug dose of instant component is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following weight:
The Radix Astragali 450-550 grams, Rhizoma Atractylodis Macrocephalae 130-160 gram, Pericarpium Citri Reticulatae 140-160 gram, Rhizoma Cimicifugae 50-80 gram, Radix Bupleuri 40-80 gram, Radix Ginseng 80-120 gram, Radix Glycyrrhizae 80-100 gram, Radix Angelicae Sinensis 140-160 gram, Fructus Rosae Laevigatae 140-160 gram, Herba Patriniae 250-350 gram, Herba Violae 140-160 gram.
Be preferably:
The Radix Astragali 500 grams, the Rhizoma Atractylodis Macrocephalae 150 grams, Pericarpium Citri Reticulatae 150 grams, Rhizoma Cimicifugae 60 grams, Radix Bupleuri 60 grams, Radix Ginseng 100 grams, 90 grams, Radix Glycyrrhizae, Radix Angelicae Sinensis 150 grams, Fructus Rosae Laevigatae 150 grams, Herba Patriniae 300 grams, Herba Violae 150 grams.
The preparation method of medicine of the present invention is as follows
One, get the raw materials ready
1, the Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
2, the Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
3, Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
4, Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
5, Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
6, Radix Ginseng: except removing LU, cutting
7, Radix Glycyrrhizae: extracting liquorice sheet, adds the ripe Mel of white silk and boiled water is a little, mixes thoroughly, slightly vexed, and put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, and 100 jin, every Radix Glycyrrhizae is with practicing ripe Mel 25-30 jin;
8, Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
9, Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
10, Herba Patriniae: summer gathers, after removing silt, dries;
11, Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
Two, prepare
1, the preparation of medicament capsule of the present invention:
(1) Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into powder, incapsulates every 0.5g.
2, the preparation of medicinal granule of the present invention:
(1) Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule.
3, the preparation of medicinal tablet of the present invention:
(1) Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
(2) filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
(3) dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every sheet 0.5g.
4, the preparation of medicine honeyed pill of the present invention:
(1) by cook the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae mixing and stirring, porphyrize powder crosses 200 order dusting covers;
(2) Mel is refined into the tender honey of 110-115 DEG C;
(3) by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball is containing pure medicine 1.5 grams.
Medicine of the present invention has strongly invigorating primordial QI, solid de-to promote the production of body fluid, the function of promoting pus discharge and tissue regeneration strengthening, is used for the treatment of uterine prolapse instant effect, good effect, does not recur.
In prescription, the Radix Astragali is useful defends consolidating superficial resistance, inducing diuresis to remove edema, and the function of promoting pus discharge and tissue regeneration strengthening is monarch drug, Herba Patriniae heat-clearing and toxic substances removing, evacuation of pus removing blood stasis with potent drugs, and Radix Ginseng has strongly invigorating primordial QI, solid de-both functions of promoting the production of body fluid are ministerial drug; Radix Angelicae Sinensis is enriched blood and is invigorated blood circulation, and the function of menstruction regulating and pain relieving is adjuvant drug, and Radix Glycyrrhizae has and middle emergency, lung moistening is detoxified, and the function of coordinating the actions of various ingredients in a prescription is for making medicine, and all medicines take stopgap measures with being left, said medicine is combined, makes each efficacy of drugs produce synergism, thus effectively can treat the recurrence of uterine prolapse.
Set forth the beneficial effect of medicine of the present invention further below by way of test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.
The animal toxicity test of [test example 1] medicine of the present invention
Get West Germany rabbit 30, male and female dual-purpose, body weight 2.0-2.5k gram, be divided into two groups, wherein one group is overdose, and another group is normal amount, a kind of dosage form in overdose group oral capsule, granule or tablet is 0.2g/kg, normal amount group is 0.1g/kg, adopts the administration of dilution administration by gavage, every twice-daily, take 7 days continuously, observation administration is reacted, and result shows that rabbit is movable, diet is normal, and medicine is without bad toxic and side effects.
The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention
1, physical data
Accept out-patient's totally 50 examples for medical treatment.
2, diagnostic criteria
Uterine prolapse clinical manifestation has: the tenesmus of patient's conscious abdominal part, the soreness of waist, to walk and more obvious when squatting down, and the block thing deviate from time serious can not also be received, impact action.Because being chronically exposed to outer, cervix uteri occurs that mucous membrane surface thickens, keratinization or rotten to the corn, ulcer occurs.Patient's leucorrhoea grow in quantity, and be pus sample or band blood sometimes, some generation menoxenias, menorrhagia.Mainly according to sign and inspection and diagnosable.
3, Therapeutic Method
Above-mentioned medicament is selected to take to patient, each serving capsule or granule or 4 grams, tablet, or honeyed pill 6 ball.Every day three times 10th is a course for the treatment of, takes 2 courses for the treatment of continuously.
4, efficacy assessment standard
Effective: uterine prolapse focus is eliminated, recovery from illness.
Take a turn for the better: patient's abdominal part bearing down alleviates, soreness of waist remission, and menstruation progressively recovers normal, and uterine prolapse situation progressively takes a turn for the better.
Invalid: not reach improvement standard person.
5, therapeutic outcome (seeing the following form):
In above-mentioned treatment, by Drug therapy later stage uterine prolapsed patient 50 example of the present invention, effective 47 examples of result, obvious effective rate is 94%, and total effective rate is 98%.
Claims (3)
1. treat a medicine for uterine prolapse, it is characterized in that: it is made up of the crude drug in following weight range:
The Radix Astragali 450-550 grams, Rhizoma Atractylodis Macrocephalae 130-160 gram, Pericarpium Citri Reticulatae 140-160 gram, Rhizoma Cimicifugae 50-80 gram, Radix Bupleuri 40-80 gram, Radix Ginseng 80-120 gram, Radix Glycyrrhizae 80-100 gram, Radix Angelicae Sinensis 140-160 gram, Fructus Rosae Laevigatae 140-160 gram, Herba Patriniae 250-350 gram, Herba Violae 140-160 gram.
2. medicine according to claim 1, wherein the consumption of each crude drug is:
The Radix Astragali 500 grams, the Rhizoma Atractylodis Macrocephalae 150 grams, Pericarpium Citri Reticulatae 150 grams, Rhizoma Cimicifugae 60 grams, Radix Bupleuri 60 grams, Radix Ginseng 100 grams, 90 grams, Radix Glycyrrhizae, Radix Angelicae Sinensis 150 grams, Fructus Rosae Laevigatae 150 grams, Herba Patriniae 300 grams, Herba Violae 150 grams.
3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:
One, get the raw materials ready
(1) Radix Astragali: pick clean impurity, the root head that removing is residual and hollow larger root, be soaked in water, pull out, run through rear timely section, dry;
(2) Rhizoma Atractylodis Macrocephalae: pick clean impurity, be soaked in water, pull out after bubble, run through, section, dries;
(3) Pericarpium Citri Reticulatae: get crude drug, the peel of removing impurity and blackening, wash quickly is clean, softens, shredding, dries or cold drying, sieve dedust bits;
(4) Rhizoma Cimicifugae: pick decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;
(5) Radix Bupleuri: pick decontamination, removes residual stem, cleans silt, pulls out, run through rear timely section, dry immediately;
(6) Radix Ginseng: except removing LU, cutting;
(7) Radix Glycyrrhizae: extracting liquorice sheet, adds the ripe Mel of white silk and boiled water is a little, mixes thoroughly, slightly vexed, and put in pot and fry to becoming buff with slow fire, till tack-free, taking-up cools, and 100 jin, every Radix Glycyrrhizae is with practicing ripe Mel 25-30 jin;
(8) Radix Angelicae Sinensis: pick decontamination, clean, moistening, slightly dries in the air, and section is dried;
(9) Fructus Rosae Laevigatae: pick decontamination, cuts two lobes, slightly soaks with water, pull out, and after moistening, the residual burr of removing, digs clean hair, core, dry;
(10) Herba Patriniae: summer gathers, after removing silt, dries;
(11) Herba Violae: get crude drug, removing impurity, cleans, slightly dries in the air, cutting, dry;
Two, prepare
(1) preparation of medicament capsule of the present invention:
1. the Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into powder, incapsulates every 0.5g;
(2) preparation of medicinal granule of the present invention:
1. the Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds ethanol and make adhesive, add starch and make filler, be pressed into granule;
(3) preparation of medicinal tablet of the present invention:
1. the Radix Astragali cooked, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae are put into decocting container and decocted with water secondary, add water 8 times amount for the first time, decoct 1.5 hours, 6 times amount that add water for the second time decoct 1 hour, merge twice decoction liquor, filter to get filtrate;
2. filtrate is condensed into the extractum that proportion is 1.35, adds 90%-95% ethanol and carry out precipitate with ethanol, reclaim ethanol and concentrate, dry at 45-50 DEG C, obtained dry extract;
3. dry extract is broken into fine powder, adds adjuvant and make granule, tabletted, every sheet 0.5g;
(4) preparation of medicine honeyed pill of the present invention:
1. by cook the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Pericarpium Citri Reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Radix Ginseng, Radix Glycyrrhizae, Radix Angelicae Sinensis, Fructus Rosae Laevigatae, Herba Patriniae, Herba Violae mixing and stirring, porphyrize powder crosses 200 order dusting covers;
2. Mel is refined into the tender honey of 110-115 DEG C;
3. by grind for fine powder spice by weight the ratio of 1:1 add mixing system in Mel and stick together, then rubbing pill, every ball is containing pure medicine 1.5 grams.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904963A (en) * | 2010-07-15 | 2010-12-08 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese medicinal herb for treating uterine prolapse |
| CN101940766A (en) * | 2010-10-13 | 2011-01-12 | 许文成 | Medicine for radically curing myocardial infarction and preparation method thereof |
| CN102743501A (en) * | 2012-06-07 | 2012-10-24 | 无为县陡沟镇中心卫生院 | Traditional Chinese medicinal formula for treating qi deficiency type uterine prolapse |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101904963A (en) * | 2010-07-15 | 2010-12-08 | 重庆市南川区瑞丰农业开发有限责任公司 | Chinese medicinal herb for treating uterine prolapse |
| CN101940766A (en) * | 2010-10-13 | 2011-01-12 | 许文成 | Medicine for radically curing myocardial infarction and preparation method thereof |
| CN102743501A (en) * | 2012-06-07 | 2012-10-24 | 无为县陡沟镇中心卫生院 | Traditional Chinese medicinal formula for treating qi deficiency type uterine prolapse |
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Application publication date: 20151111 |