CN105031029A - Traditional Chinese medicinal capsules for treating degenerative osteoarthritis - Google Patents
Traditional Chinese medicinal capsules for treating degenerative osteoarthritis Download PDFInfo
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- CN105031029A CN105031029A CN201510371109.0A CN201510371109A CN105031029A CN 105031029 A CN105031029 A CN 105031029A CN 201510371109 A CN201510371109 A CN 201510371109A CN 105031029 A CN105031029 A CN 105031029A
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Abstract
The invention discloses traditional Chinese medicinal capsules for treating degenerative osteoarthritis. The traditional Chinese medicinal capsules are prepared from the following traditional Chinese medicinal materials in parts by weight: 15 parts of radix rehmanniae preparata, 20 parts of fructus lycii, 18 parts of radix astragali, 12 parts of pyrolusite, 8 parts of semen nigellae, 10 parts of safflowers, 12 parts of ammoniac, 6 parts of achyranthes bidentata, 20 parts of tragacanth, 6 parts of fructus arctii, 6 parts of bombyx batryticatus, 25 parts of phlogacanthus curviflorus, 10 parts of gossypium herbaceum, 5 parts of sapium baccatum, 6 parts of wild string beans, 6 parts of aizoon stonecrop herb and 6 parts of pine pollen disruption powder. A clinical experiment shows that the remarkable effect of treating degenerative osteoarthritis can be achieved by selecting proper medicinal materials and a proper proportion and the traditional Chinese medicinal capsules are safe and free of toxic or side effects.
Description
Technical field
the present invention relates to a kind of Chinese medicinal capsule, be specifically related to a kind of Chinese medicinal capsule being used for the treatment of degenerative osteoarthritis.
Background technology
degenerative osteoarthritis is a kind of degeneration, is the articular cartilage degeneration damage because the factors such as increasing age, obesity, strain, wound, joint birth defect, joint deformity cause, joint margins and subchondral bone reactive hyperplasia.Primary disease is more common in mid-aged population, is apt to occur in weight-bearing joints and the more joint of activity.Excessive heavy burden or use these joints, all can promote the generation that degeneration changes.Clinical manifestation is the arthralgia of slowly development, tenderness, stiff, arthroncus, limitation of activity and joint deformity etc.Cardinal symptom is arthralgia, is often rest pain, occurs pain after showing as rest, and namely movable a moment is alleviated, but after hyperactivity, pain is aggravated again.Another symptom is ankylosis, often appears at WA or after daytime, joint kept certain position for a long time in morning.Check the swelling of affected joints visible joint, tenderness, have friction sense or " click clatter " sound time movable, the person of being in a bad way can have amyotrophy and joint deformity.Its cause of disease it be unclear that.Treatment for degenerative osteoarthritis still lacks the effective medicine of generally recognized as safe at present.
Summary of the invention
the present invention aims to provide a kind of Chinese medicinal capsule being used for the treatment of degenerative osteoarthritis and preparation method thereof, by selecting suitable medical material and proportioning thereof, reaches the remarkable efficacy contributing to treating degenerative osteoarthritis, and safe without toxic side effect.
in order to achieve the above object, the present invention is by the following technical solutions:
be used for the treatment of a Chinese medicinal capsule for degenerative osteoarthritis, be prepared from by the Chinese crude drug of following weight proportion: Radix Rehmanniae Preparata 15 parts, Fructus Lycii 20 parts, the Radix Astragali 18 parts, black stone 12 parts, wild Fructus Cumini Cymini 8 parts, 10 parts, Flos Carthami, ammoniac 12 parts, Radix Achyranthis Bidentatae 6 parts, tragacanth 20 parts, Fructus Arctii 6 parts, Bombyx Batryticatus 6 parts, Radix Phlogacanthi curviflori 25 parts, cotton 10 parts, Sapium baccatum Roxb 5 parts, wild Semen Canavaliae 6 parts, Herba Sedi Aizoon 6 parts, breaking cellular wall Pollen Pini 6 parts.
the pharmacology analysis of each Chinese medicinal ingredients of the present invention is as follows:
the Preparation process product of Radix Rehmanniae Preparata [source] Radix Rehmanniae.[nature and flavor] are sweet, tepor.[return through] returns liver, kidney channel.[function cures mainly] nourishing YIN and supplementing blood, beneficial essence fills out marrow.
the dry root of the Radix Astragali [source] leguminous plant Radix Astagali.[nature and flavor] are sweet, temperature.[return through] returns lung, spleen channel.[function cures mainly] invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.
the nodular pyrolusite stone of black stone [source], is also called pyrolusitum.[nature and flavor] are salty, sweet, flat.[function cures mainly] promoting blood circulation and hemostasis, subduing swelling and relieving pain.For traumatic injury, swollen ulcer drug, wound hemorrhage.
wild Fructus Cumini Cymini [source] is the seed of the wild Fructus Cumini Cymini of umbrella section plant.[nature and flavor] three grades are xeothermic, acrid in the mouth.[function cures mainly] raw dry heat-dissipating, strong muscle is good for flesh, and except the insane hysteria that disappears, cold-dispelling pain-relieving, warming the lung to relieve cough, drying dampness to eliminate phlegm, diuresis and expelling stone, dispelling wind for relieving itching, changes tired speckle dispelling.Cure mainly humid or lymphatic temperament disease, as paralysis, disease of flaccid muscles, epilepsy, hysteria, marrow arthralgia, size arthralgia, sciatica, cold cough, moist abundant expectoration, renal calculus, tinea capitis, skin pruritus, various speckle warts etc.
the dried floral of Flos Carthami [source] feverfew Flos Carthami.[nature and flavor] are pungent, temperature.[return through] GUIXIN, Liver Channel.[function cures mainly] promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.
the resin of ammoniac [source] samphire ammonia grindelia.[nature and flavor] bitter in the mouth and pungent.[function cures mainly] opens liver resistance, dissolves calculus, and warm brain is except insane, and strong muscle is good for flesh, strengthens consciousness etc.The dirty retardance for the treatment of the liver, kidney stone, serious sinusitis with purulent discharge is insane silly, paralysis, numb limbs and tense tendons etc.
the dry root of Radix Achyranthis Bidentatae [source] amaranthaceous plant Radix Achyranthis Bidentatae.[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.
tragacanth [source] is leguminous plant Calculus Bovis from Northwest of China stilbene and the glue fat belonging to his kind of plant together.[nature and flavor] are flat, partially wet, lightly seasoned.[function cures mainly] corrects the evil of hundred tastes, raw moistening lung, cough-relieving, hemostasis, sore throat relieving profit larynx, tonneau urine, and antiinflammatory is healed skin ulcer.Cure mainly dryness and partially contain caused various diseases, as dryness of the lung dry cough, dry laryngopharynx, hoarseness, intestinal ulcer, urethra skin infection, burning sensation during urination.
fructus Arctii [source] this product is the dry mature fruit of feverfew Fructus Arctii.[nature and flavor] are pungent, bitter, cold.[return through] attaches to the lung and stomach meridians.[function cures mainly] dispelling wind and heat pathogens, lung qi dispersing rash, resolving toxin and disinhibiting the throat.
the larva of Bombyx Batryticatus [source] Bombycidae insecticide bombyx mori infects muscardine and ossified dry Scorpio.[nature and flavor] acrid in the mouth; Salty; Property is put down.[return through] liver; Lung; Stomach warp.[function cures mainly] expellings wind and relieving convulsion; Dissipating phlegm and resolving masses; Resolving toxin and disinhibiting the throat.The main chronic ulcerated twitch;In tuyere slanting eyes oblique;S headaches;Sore throat;Scrofula.Mumps;Rubella;Chuangdu.
the root that Radix Phlogacanthi curviflori [source] is acanthaceous plant Radix Phlogacanthi curviflori and leaf.[nature and flavor] bitter in the mouth, gas is smelly, cold in nature.[function cures mainly] Qinghuo Jiedu, dispel the wind diuretic, cooling blood and relieving pain.Cure mainly anemopyretic cold, cough, laryngopharynx swelling and pain, gastral cavity abdomen spasm severe pain, rheumatic fever arthromyodynia, limbs joint red and swollen heat pain, joint stuffiness, arthralgia due to wind-cold-dampness disease, limbs joint are ached, joint stuffiness, traumatic injury, headache and dizziness, breast abdominal distention are vexed.
the root that cotton [source] is Malvaceae plant cotton and seed.[nature and flavor] bitter in the mouth is sweet, micro-puckery, cool in nature.[function cures mainly] Qinghuo Jiedu, diuresis and expelling stone, relieving cough and asthma, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain.Cure mainly the puckery pain of urine heat, lithangiuria, asthma, traumatic injury.
the dry mature fruit of Fructus Lycii [source] plant of Solanaceae lycium barbarum.[nature and flavor] are sweet, flat.[return through] returns liver, kidney channel.[function cures mainly] nourishing the liver and kidney, replenishing vital essence to improve eyesight.
the root that Sapium baccatum Roxb [source] is euphorbia plant Sapium baccatum Roxb.[nature and flavor] taste is micro-puckery, and property is put down.[function cures mainly] adjusts benefit four tower, and regulating menstruation and activating blood, mends native stomach invigorating, promoting the circulation of QI to relieve pain.How sick, weak cure mainly and have a delicate constitution, menstruation point is adjusted, dysmenorrhea, amenorrhea, abdominal distention, anorexia.
the seed of the wild Semen Canavaliae of wild Semen Canavaliae [source] leguminous plant and root.[nature and flavor] taste is sweet.Property is put down.Enter four towers.[function cures mainly] adjusts benefit four tower, Qinghuo Jiedu, killing parasites for relieving itching.Cure mainly have a delicate constitution how sick, weak, anorexia, insomnia, furuncle carbuncle furuncle abscess, skin pruritus, macule, scabies, eczema.
herba Sedi Aizoon [source] medical material Ji Yuan: be root or the herb of crassulaceae plants Herba sedi kamtschatici, horizontal root Herba sedi kamtschatici.[nature and flavor] put down; Sweet; Micro-acid.[return through] heart; Liver; Spleen channel.[function cures mainly] dissipating blood stasis; Hemostasis; Mind tranquilizing and the heart calming; Removing toxic substances.Main haematemesis; Epistaxis; Have blood in stool; Hematuria; Metrorrhagia; Purpura; Traumatic hemorrhage; Traumatic injury; Cardiopalmus; Insomnia; Furuncle carbuncle; Burn and scald; Insect bite.
breaking cellular wall Pollen Pini [source] medical material Ji Yuan: Pollen Pini is the spermatid of pinaster pistil, having another name called pine yellow, is pure, the dry pollen that pick up from China indigenous tree pinaceae plant Pinus massoniana Lamb.[function cures mainly], containing the whole active nutritional compositions needed for life entity, comprising multiple proteins, aminoacid, mineral, enzyme and coenzyme, nucleic acid, monosaccharide, polysaccharide etc., total content reaches more than 200 and plants.Also nearly hundred kinds of enzymes, biotin, nucleic acid, cellulose, unsaturated fatty acid, Flavonoid substances, rutin isoreactivity materials are contained in addition in Pollen Pini.
the present invention compared with prior art, has following beneficial effect:
1, Chinese medicine preparation of the present invention for treatment degenerative osteoarthritis cure rate high and safe without toxic side effect, and can related complication be prevented.Between formula medical material, compatibility is rigorous, the synergistic function produced after not only making full use of compatibility of drugs, and avoid pharmaceutically-active mutual Hangzhoupro short of money and offset or slacken original effect, more note selecting the compatibility of drugs application that can alleviate or eliminate the strong of medicine or toxic and side effects, firmly avoid the mutual compatibility of medicine and produce toxic reaction or strong side effect.In the present invention, Fructus Arctii: cool in nature, acrid in the mouth is bitter, eliminating phlegm for diminishing swelling, current twelve channels and collaterals; Bombyx Batryticatus: property is flat, acrid in the mouth is salty, expelling wind to relieve convulsion, dissipating phlegm and resolving masses.Fructus Arctii, Bombyx Batryticatus, the application of both compatibilities can pass through the twelve regular channels, open brokenly expectorant knot, lead its knot stagnant, declare and reach QI and blood, relieving rigidity of joints.Share with liver and kidney tonifying with Radix Rehmanniae Preparata, Fructus Lycii, Radix Phlogacanthi curviflori, Radix Achyranthis Bidentatae, ammoniac again, bone and muscle strengthening; Radix Astragali invigorating qi and benefiting blood; Flos Carthami, black stone are invigorated blood circulation promoting the circulation of blood; Radix Phlogacanthi curviflori wind-expelling pain-stopping; Tragacanth coordinating the actions of various ingredients in a prescription, plays the merit of invigorating the liver and kidney, bone and muscle strengthening, analgesic therapy of invigorating blood circulation altogether.By scientific compatibility, not only complicated in the state of an illness, when fast changing, the present invention can not only effectively organize and implement reasonable treatment, make it reach medicine to remove to disease, and for prevent disease progress, in invade internal organs also have good preventive effect, very valuable on clinical application.
2, Chinese medicine preparation of the present invention selects high-quality Chinese crude drug to make, selected medical material compatibility is suitable, meet Chinese medicine and modern medicine study theory, and utilize modern medicine pharmaceutical technology to make, safe without toxic side effect, reach the object for the treatment of both the principal and secondary aspects of a disease, and source is easy to get, economical, clinic is applied.
Detailed description of the invention
in order to understand better and implement the present invention, further illustrate the present invention below in conjunction with specific embodiment.
embodiment 1
take: Radix Rehmanniae Preparata 15 grams, Fructus Lycii 20 grams, the Radix Astragali 18 grams, black stone 12 grams, wild Fructus Cumini Cymini 8 grams, 10 grams, Flos Carthami, ammoniac 12 grams, Radix Achyranthis Bidentatae 6 grams, tragacanth 20 grams, Fructus Arctii 6 grams, Bombyx Batryticatus 6 grams, Radix Phlogacanthi curviflori 25 grams, cotton 10 grams, Sapium baccatum Roxb 5 grams, wild Semen Canavaliae 6 grams, Herba Sedi Aizoon 6 grams, breaking cellular wall Pollen Pini 6 grams.
preparation method is: (1) mixes after above-mentioned medical material is removed impurity respectively, sends in drying baker and dries at 120 DEG C of temperature, be ground into 100-130 order smalls, incapsulate, be finished product after disinfection by ultraviolet light by 0.5g/ grain.
usage and dosage: oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; Within 30 days, be 1 course for the treatment of, take 2 courses for the treatment of continuously.
clinical data:
1, case selection:
select the routine clinical observation of degenerative osteoarthritis patient 59 in my institute's diagnosis and treatment, clinical symptoms all meets degenerative osteoarthritis diagnosis and treatment standard.Patient is divided into treatment group and matched group two groups at random, treatment group 32 example, matched group 27 example.The course of disease, the degrees of symptoms for the treatment of group and matched group two groups of cases are basically identical, without significant difference, have comparability.
2, medicament selection:
treatment group takes the Chinese medicinal capsule preparation obtained by the embodiment of the present invention 1, oral, every day 2 times, each 1 time sooner or later, each 1, warm water delivery service after meal; It within 30 days, is 1 course for the treatment of.
matched group adopts conventional western medicine Comprehensive Treatment, the course for the treatment of same treatment group.
2 courses for the treatment of are treated in continuous smelting, contrast two groups of curative effects.
3, efficacy determination:
" the new Chinese medicine guideline of clinical investigations " issued with reference to Ministry of Public Health is drafted:
(1) cure: clinical symptoms disappears substantially, knee joint function recovers normal.
(2) take a turn for the better: clinical symptoms have in various degree or partial symptoms disappear, knee joint function is normal.
(3) do not heal: clinical symptoms and sign treatment front and back are without significant change.
4, result:
select in the treatment group of the embodiment of the present invention 1 Chinese medicinal capsule, cure 26 examples, take a turn for the better 4 examples, and do not heal 2 examples, cure rate 81.3%, total effective rate 93.8%.
cure 10 examples in matched group, take a turn for the better 11 examples, and do not heal 6 examples, cure rate 37.3%, total effective rate 77.8%.
above result display, the cure rate for the treatment of group and total effective rate are apparently higher than matched group.
obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention.Relevant Chinese medicine also exists rectification of name, different name, calls and be commonly called as, and the concrete medical material referred to all can be known by existing open source literature and network, also can with the substitute in the medical material generation of close effect.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here cannot give exhaustive to all embodiments.Every belong to technical scheme of the present invention the apparent change of extending out or variation be still in the row of protection scope of the present invention.
Claims (1)
1. one kind is used for the treatment of the Chinese medicinal capsule of degenerative osteoarthritis, it is characterized in that, be prepared from by the Chinese crude drug of following weight proportion: Radix Rehmanniae Preparata 15 parts, Fructus Lycii 20 parts, the Radix Astragali 18 parts, black stone 12 parts, wild Fructus Cumini Cymini 8 parts, 10 parts, Flos Carthami, ammoniac 12 parts, Radix Achyranthis Bidentatae 6 parts, tragacanth 20 parts, Fructus Arctii 6 parts, Bombyx Batryticatus 6 parts, Radix Phlogacanthi curviflori 25 parts, cotton 10 parts, Sapium baccatum Roxb 5 parts, wild Semen Canavaliae 6 parts, Herba Sedi Aizoon 6 parts, breaking cellular wall Pollen Pini 6 parts.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311374A (en) * | 2015-12-02 | 2016-02-10 | 王平平 | Medicine for treating gouty arthritis |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225129A (en) * | 2011-06-21 | 2011-10-26 | 马玉伟 | Traditional Chinese medicine composite for treating degenerative osteoarthritis and preparation method thereof |
| CN103393840A (en) * | 2013-07-24 | 2013-11-20 | 赵世明 | Traditional Chinese medicine composition for treating osteoarthritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102225129A (en) * | 2011-06-21 | 2011-10-26 | 马玉伟 | Traditional Chinese medicine composite for treating degenerative osteoarthritis and preparation method thereof |
| CN103393840A (en) * | 2013-07-24 | 2013-11-20 | 赵世明 | Traditional Chinese medicine composition for treating osteoarthritis |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105311374A (en) * | 2015-12-02 | 2016-02-10 | 王平平 | Medicine for treating gouty arthritis |
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