CN105013007A - Preparation method of polylactide material used for artificial nerve conduit - Google Patents
Preparation method of polylactide material used for artificial nerve conduit Download PDFInfo
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- CN105013007A CN105013007A CN201510384493.8A CN201510384493A CN105013007A CN 105013007 A CN105013007 A CN 105013007A CN 201510384493 A CN201510384493 A CN 201510384493A CN 105013007 A CN105013007 A CN 105013007A
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- polylactide
- artificial nerve
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- nerve catheter
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Abstract
The invention discloses a preparation method of a polylactide material used for an artificial nerve conduit, which comprises the following steps: 1)weighing components according to weight part: 2)uniformly mixing the components in a mixer; 3)placing the uniformly mixed materials in a reaction vessel, heating under condition of vacuum degree, stirring, cooling and stirring to obtain a mixture; and 4)placing the mixture in a double screw extruder for extrusion to obtain the medical plastic. The preparation method has the advantages of short flow, simple operation, low cost, friendliness to environment, and high economic benefit. Compared with the prior art, the compatibility and security of the prepared polylactide material are increased, and the polylactide material has good application prospect on field of biological medical material.
Description
Technical field
The invention belongs to polymeric material field, relate to a kind of preparation method of artificial nerve catheter polylactide material.
Technical background
Plastics to obtain at medical field with its excellent character, reliably performance, easily moulding process and apply more and more widely, make plastic material prepare medical supplies and have development prospect.First plastics have good physical and mechanical property and chemical stability, compare and are adapted at medical field use; Secondly macromolecular material abundance, cheap, is applicable to making disposable medical article, avoids traditional material goods have to repeatedly use sterilization and the cross infection caused problem because price is high; And plastics have or are easier to modification and obtain good histocompatibility, blood compatibility goods; Also have plastic processing convenient, cost of manufacture is low, is applicable to multiple molding mode, is convenient to be processed into complicated shape and development of new medical product.
From the thirties in 20th century, people use synthesized polymer material first---and since the artificial kidney that xylonite film is made as dialyzer is applied to clinical succeeding, macromolecular material is progressively substituting conventional inorganic material if metal (or alloy), glass, pottery, apatite etc. are for the preparation of medical supplies.1949, first the U.S. delivered the prospect paper of medical high polymer, and first time describes and utilizes polymethyl methacrylate (PMMA) as the skull of people, joint and femur, utilizes Fypro as the clinical practice situation of operation suture thread.The 1950's, organosilicon polymer is used to medical domain, and the range of application of artificial organ is expanded greatly, comprises organ and substitutes and many aspects such as face-lifting.In the 1950's, large quantities of artificial organ is tried out in clinical, as artificial urethra (nineteen fifty), artificial blood vessel's (nineteen fifty-one), artificial esophagus's (nineteen fifty-one), Cardiac valve prosthesis (nineteen fifty-two), artificial heart-lung (nineteen fifty-three), artificial heart-lung (nineteen fifty-three), artificial joint (1954) and artificial liver (1958) etc.The sixties in 20th century, medical macromolecular materials start to enter a brand-new developing period.
At present, the plastic in nervous system is mainly artificial nerve catheter, and artificial nerve catheter is mainly used in the reparation of injured nerve, is to be hopeful most at present to obtain to break through to be applied to one of clinical project.Medical circle was studying the application of degradative plastics in nerve trachea in recent years, mainly contained PGA, polylactide, collagen etc.Due to contact with medicinal liquid or and human contact, the basic demand of medical grade plastic materials has chemical stability and biological safety.In simple terms, the constituent in plastic material can not be separated out and be entered medicinal liquid or human body, can not cause toxicity and the damage of histoorgan, is nontoxic to human body.For improving blood compatibility, the histocompatibility of goods, need the modifying surface to goods.The plastic tool anti-infection property getting involved life-time service in human body is one of research and development direction of current medical grade plastic materials.In sum, a kind of compatibility is high, safety is high medical artificial nerve catheter plastic material is badly in need of providing to be this area technical problem urgently to be resolved hurrily.
Summary of the invention
The object of the invention is to for the deficiencies in the prior art, a kind of preparation method of artificial nerve catheter polylactide material is provided.
The object of the invention is to be achieved through the following technical solutions: a kind of preparation method of artificial nerve catheter polylactide material, said method comprising the steps of: step one, polylactide 30-40 part is taken according to weight portion, xanthan gum 25-40 part, styrene 2-6 part, tributyl citrate 1-6 part, magnesium borate crystal whisker 2-7 part, calcium lignosulfonate 3-8 part, glycerol 3-8 part, divinyl tetramine 2-6 part, dispersant 2-13 part, glass fibre 5-22 part, precipitated calcium carbonate 12-20 part, high density polrvinyl chloride 10-20 part, plasticizer 5-10 part, ethylene glycol 3-5 part, lubricant 1-3 part, antioxidant 2-4 part, step 2, by each component mix homogeneously in mixing and blending machine, step 3, the material after mix homogeneously being put into reactor, is be heated to 100-120 DEG C under the condition of 1-3MPa in vacuum, stirs 10-20 minute, is cooled to 30-40 DEG C, stirs 5-10 minute, obtains mixed material,
Step 4, mixed material is placed in double screw extruder at 180-200 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described plasticizer is tributyl citrate.
Described antioxidant is irgasfos 168.
Described lubricant is barium stearate.
Described dispersant is the one in Tissuemat E, OPE, polyamide wax.
The present invention has following beneficial effect: preparation method flow process of the present invention is shorter, simple to operate, and cost is low, environmentally friendly, high financial profit.Its compatibility is high compared to existing technology, safety is high significantly improves for the artificial nerve catheter polylactide material prepared by method of the present invention, is applied in biomedical materials field and has a good application prospect.
Detailed description of the invention
embodiment 1
A preparation method for artificial nerve catheter polylactide material, preparation method comprises the following steps: step one, take polylactide 30 parts, xanthan gum 25 parts, styrene 2 parts, tributyl citrate 1 part, magnesium borate crystal whisker 2 parts, calcium lignosulfonate 3 parts, glycerol 3 parts, divinyl tetramine 2 parts, dispersant 2 parts, glass fibre 5 parts, precipitated calcium carbonate 12 parts, high density polrvinyl chloride 10 parts, plasticizer 5 parts, ethylene glycol 3 parts, lubricant 1 part, 2 parts, antioxidant according to weight portion; Step 2, by each component mix homogeneously in mixing and blending machine; Step 3, the material after mix homogeneously being put into reactor, is be heated to 100-120 DEG C under the condition of 1-3MPa in vacuum, stirs 10-20 minute, is cooled to 30-40 DEG C, stirs 5-10 minute, obtains mixed material;
Step 4, mixed material is placed in double screw extruder at 180-200 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described plasticizer is tributyl citrate.
Described antioxidant is irgasfos 168.
Described lubricant is barium stearate.
Described dispersant is the one in Tissuemat E, OPE, polyamide wax.
embodiment 2
A preparation method for artificial nerve catheter polylactide material, preparation method comprises the following steps: step one, take polylactide 40 parts, xanthan gum 40 parts, styrene 6 parts, tributyl citrate 6 parts, magnesium borate crystal whisker 7 parts, calcium lignosulfonate 8 parts, glycerol 8 parts, divinyl tetramine 6 parts, dispersant 13 parts, glass fibre 22 parts, precipitated calcium carbonate 20 parts, high density polrvinyl chloride 20 parts, plasticizer 10 parts, ethylene glycol 5 parts, lubricant 3 parts, 4 parts, antioxidant according to weight portion; Step 2, by each component mix homogeneously in mixing and blending machine; Step 3, the material after mix homogeneously being put into reactor, is be heated to 100-120 DEG C under the condition of 1-3MPa in vacuum, stirs 10-20 minute, is cooled to 30-40 DEG C, stirs 5-10 minute, obtains mixed material;
Step 4, mixed material is placed in double screw extruder at 180-200 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described plasticizer is tributyl citrate.
Described antioxidant is irgasfos 168.
Described lubricant is barium stearate.
Described dispersant is the one in Tissuemat E, OPE, polyamide wax.
embodiment 3
A preparation method for artificial nerve catheter polylactide material, preparation method comprises the following steps: step one, take polylactide 35 parts, xanthan gum 30 parts, styrene 4 parts, tributyl citrate 4 parts, magnesium borate crystal whisker 4 parts, calcium lignosulfonate 5 parts, glycerol 5 parts, divinyl tetramine 4 parts, dispersant 6 parts, glass fibre 14 parts, precipitated calcium carbonate 16 parts, high density polrvinyl chloride 15 parts, plasticizer 7 parts, ethylene glycol 4 parts, lubricant 2 parts, 3 parts, antioxidant according to weight portion; Step 2, by each component mix homogeneously in mixing and blending machine; Step 3, the material after mix homogeneously being put into reactor, is be heated to 100-120 DEG C under the condition of 1-3MPa in vacuum, stirs 10-20 minute, is cooled to 30-40 DEG C, stirs 5-10 minute, obtains mixed material;
Step 4, mixed material is placed in double screw extruder at 180-200 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
Described plasticizer is tributyl citrate.
Described antioxidant is irgasfos 168.
Described lubricant is barium stearate.
Described dispersant is the one in Tissuemat E, OPE, polyamide wax.
The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with preferred embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be the content not departing from technical solution of the present invention, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (5)
1. the artificial nerve catheter preparation method of polylactide material, it is characterized in that, said method comprising the steps of: step one, polylactide 30-40 part is taken according to weight portion, xanthan gum 25-40 part, styrene 2-6 part, tributyl citrate 1-6 part, magnesium borate crystal whisker 2-7 part, calcium lignosulfonate 3-8 part, glycerol 3-8 part, divinyl tetramine 2-6 part, dispersant 2-13 part, glass fibre 5-22 part, precipitated calcium carbonate 12-20 part, high density polrvinyl chloride 10-20 part, plasticizer 5-10 part, ethylene glycol 3-5 part, lubricant 1-3 part, antioxidant 2-4 part, step 2, by each component mix homogeneously in mixing and blending machine, step 3, the material after mix homogeneously being put into reactor, is be heated to 100-120 DEG C under the condition of 1-3MPa in vacuum, stirs 10-20 minute, is cooled to 30-40 DEG C, stirs 5-10 minute, obtains mixed material,
Step 4, mixed material is placed in double screw extruder at 180-200 DEG C extrudes batten through water-cooled, air-dry, pelletizing, to obtain final product.
2. the preparation method of a kind of artificial nerve catheter polylactide material according to claim 1, it is characterized in that, described plasticizer is tributyl citrate.
3. the preparation method of a kind of artificial nerve catheter polylactide material according to claim 1, it is characterized in that, described antioxidant is irgasfos 168.
4. the preparation method of a kind of artificial nerve catheter polylactide material according to claim 1, it is characterized in that, described lubricant is barium stearate.
5. the preparation method of a kind of artificial nerve catheter polylactide material according to claim 1, it is characterized in that, described dispersant is the one in Tissuemat E, OPE, polyamide wax.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510384493.8A CN105013007A (en) | 2015-06-30 | 2015-06-30 | Preparation method of polylactide material used for artificial nerve conduit |
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| CN201510384493.8A CN105013007A (en) | 2015-06-30 | 2015-06-30 | Preparation method of polylactide material used for artificial nerve conduit |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106280342A (en) * | 2016-08-30 | 2017-01-04 | 胡何辉 | A kind of PP composite material being applicable to medical infusion bags and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230623A (en) * | 2013-05-10 | 2013-08-07 | 南通大学 | Method for in-vitro construction of tissue engineered nerves |
| CN103965600A (en) * | 2014-05-23 | 2014-08-06 | 上海交通大学 | Method for toughening heat-resistant modified polylactic acid with plant-base composite environment-friendly modifier |
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2015
- 2015-06-30 CN CN201510384493.8A patent/CN105013007A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230623A (en) * | 2013-05-10 | 2013-08-07 | 南通大学 | Method for in-vitro construction of tissue engineered nerves |
| CN103965600A (en) * | 2014-05-23 | 2014-08-06 | 上海交通大学 | Method for toughening heat-resistant modified polylactic acid with plant-base composite environment-friendly modifier |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106280342A (en) * | 2016-08-30 | 2017-01-04 | 胡何辉 | A kind of PP composite material being applicable to medical infusion bags and preparation method thereof |
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Application publication date: 20151104 |