CN108084638A - A kind of medical grade modified polyetheretherketonefiber and preparation method - Google Patents
A kind of medical grade modified polyetheretherketonefiber and preparation method Download PDFInfo
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- CN108084638A CN108084638A CN201711471250.3A CN201711471250A CN108084638A CN 108084638 A CN108084638 A CN 108084638A CN 201711471250 A CN201711471250 A CN 201711471250A CN 108084638 A CN108084638 A CN 108084638A
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- ether
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K9/00—Use of pretreated ingredients
- C08K9/04—Ingredients treated with organic substances
- C08K9/06—Ingredients treated with organic substances with silicon-containing compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/18—Oxygen-containing compounds, e.g. metal carbonyls
- C08K3/20—Oxides; Hydroxides
- C08K3/22—Oxides; Hydroxides of metals
- C08K2003/2237—Oxides; Hydroxides of metals of titanium
- C08K2003/2241—Titanium dioxide
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/32—Phosphorus-containing compounds
- C08K2003/321—Phosphates
- C08K2003/325—Calcium, strontium or barium phosphate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K2201/00—Specific properties of additives
- C08K2201/011—Nanostructured additives
Abstract
The present invention discloses a kind of medical grade modified polyetheretherketonefiber, while additionally provides its preparation method, using the technique of " first solution disperses, then grinding distribution, then high speed dispersion, rear injection blending ".Blend is obtained by homogeneous dispersion point nano material and polyether-ether-ketone, through milling apparatus grinding distribution after drying, it is uniformly mixed again with remaining polyether-ether-ketone by homogenizer, you can carry out extrusion processing, obtain the plastic grain of novel polyether ether ketone composite material.The composite material has excellent mechanical property and biology performance, and mechanical strength is more than 2 times of pure polyether-ether-ketone, can also be applied to aerospace material and the relevant field of biological engineering material.
Description
Technical field：
The present invention discloses a kind of medical grade modified polyetheretherketonefiber, while additionally provides its preparation method, is suitble to make in medical field
Modified polyetheretherketonefiber composite material, belongs to technical field of polymer materials.
Background technology
Being now widely used for clinical titanium or titanium alloy metal has a fabulous mechanical strength, but its processing difficulties,
And compatibility with organism, biocompatibility are poor.The mechanical strength of ceramic base bone implant material much exceeds bone tissue,
Stress shielding easily occurs after being implanted into vivo, and then causes bone information, osteanabrosis, and further results in implant loosening and draws
Play a series of complication.Conventional polymer material is far below the intensity of bone, reaches as PMMA, HDPE, PLA etc., mechanical strength
It is required less than implantation.
Polyether-ether-ketone（PEEK）It is a kind of complete fragrant Piezoelectricity, satisfactory mechanical property, and with excellent resistance to spoke
The features such as penetrating property, insulating properties, in traditional materials such as the alternative metal of many special dimensions, ceramics, mitigates weight and does not influence to make
Use performance.In medical instruments field, PEEK is more and more wider in the clinical practice of spinal operation, wound and orthopaedics class medical product
It is general.Compared with other implantation materials, PEEK has preferable biocompatibility and adjustable mechanical property, is manufactured with PEEK
The elasticity modulus of artificial bone matches with bone tissue, and it is with high intensity, solvent resistance and through sterilizing and mechanical strength repeatedly
It does not degenerate, therefore PEEK has apparent advantage, is more suitable for carrying out long-term et al. Ke.But PEEK is as bio-inert material,
It lacks bioactivity, cannot form stable interface between living tissue during applied to Bone Defect Repari, Integrated implant, it is difficult to people
Body bone forms bone fusion so that uses of the PEEK in medical field is greatly restricted.
The content of the invention：
For this deficiency, this patent develops the preparation method of the PEEK composite materials of medical grade, whole to improve the bone of PEEK
Close performance.It is i.e. with unique technique that nano material is compound with PEEK, the bioactivity of PEEK is remarkably improved, and is ensured enough
Intensity and good biocompatibility, there is higher Clinical practice value and vast market prospect.
The technical problem to be solved in the present invention is to provide a kind of preparation method of medical grade modified polyetheretherketonefiber.
The present invention provides nano material, high temperature resistant coupling agent and the compound obtained composite materials of polyether-ether-ketone.
The present invention also provides the preparation method of the composite material described in above-mentioned technical proposal, the formula including composite material
And the preparation process of composite material.
Include the following steps：
1. it is according to mass ratio by coupling agent, nano material:（0.01~0.1）：1 ratio weighs, and is placed in the mixing of second alcohol and water
The shearing of solution high speed is scattered, wherein, the volume ratio of second alcohol and water is 1：9~9:1, shearing rate of dispersion is 400 ~ 1200r/
Min, disperse 1 ~ 9 it is small when after add in polyether-ether-ketone powder, wherein, the mass ratio of polyether-ether-ketone powder and nano material is 1 ~ 3:1,
Continue to filter after disperseing 1 ~ 5 hour, obtained pre-composition is placed in 150 DEG C ~ 160 DEG C of baking oven and is dried, during drying
Between for 8 ~ for 24 hours；
2. obtained pre-composition is added in milling apparatus be ground it is scattered, grinding rate be 800 ~ 2000r/min, grinding
Time is 5min ~ 20min；
It is blended 3. the blend that grinding obtains is placed in remaining polyether-ether-ketone powder in homogenizer, mixing time 5min
~ 20min, stir speed (S.S.) are 800 ~ 1500r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 330 ~ 420 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Preferably, the high temperature resistant coupling agent of the addition is γ-chloropropyl triethoxysilane, γ-(2,3- epoxies third
Oxygen) one or both of propyl trimethoxy silicane mixture.
Preferably, the nano material of the addition is hydroxyapatite（HA）, nanometer fluor-apatite, in nano-titanium dioxide
One or more of mixtures.
Preferably, the high temperature resistant coupling agent of the addition and the mass ratio of nano material are 0.1:10~0.6:10.
Preferably, the mass ratio of the nano material of the addition and polyether-ether-ketone is 1:9~5:5.
Preferably, the polyether-ether-ketone state of the addition is powdery, and high temperature resistant coupling agent is powdery, and inorganic pigment is liquid
State, nano material are powdery.
The good effect of invention is：
Provide its preparation method and the application of a kind of nano material/polyether-ether-ketone composite material.I.e.：Using " first solution disperses,
The technique of grinding distribution again, then high speed dispersion, rear injection blending ".It is obtained by homogeneous dispersion point nano material and polyether-ether-ketone
To blend, through milling apparatus grinding distribution after drying, then it is uniformly mixed by homogenizer with remaining polyether-ether-ketone, you can
Extrusion processing is carried out, obtains the plastic grain of novel polyether ether ketone composite material.
The composite material has excellent mechanical property and biology performance, and mechanical strength is more than the 2 of pure polyether-ether-ketone
Times, it can also be applied to aerospace material and the relevant field of biological engineering material.
The composite material has good biocompatibility and bioactivity, has the more matched mechanics compatible with bone tissue
Property, can stimulation of bone growth, accelerate knitting, reduce bone implant material after wound healing time.
The performances such as intensity, toughness, the modulus of the bone repair prepared by the composite material are matched with people's bone photo, and corrosion-resistant
Performance is good, and service life is long, is fully able to meet the clinical needs for Bone Defect Repari.
Specific embodiment
By following embodiment further illustrate description the present invention, do not limit the invention in any way, without departing substantially from
On the premise of the technical solution of the present invention, easy to implement any of those of ordinary skill in the art made for the present invention changes
Dynamic or change is fallen within scope of the presently claimed invention.
Embodiment 1
1. weighing γ-chloropropyl triethoxysilane 16g, nanometer fluor-apatite 400g places it in the mixing of 10L second alcohol and waters
The shearing of solution high speed is scattered, and wherein the volume ratio of second alcohol and water is 1：9, shearing rate of dispersion be 600r/min, disperse 7 it is small when
600g polyether-ether-ketone powder is added in afterwards, is continued to filter after disperseing 1 hour, obtained blend is placed in 160 DEG C of baking oven
It is dried, drying time 18h；
2. obtained pre-composition is added in milling apparatus, grinding rate 1500r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 1Kg）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 330 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 121Mpa, bending strength 169Mpa, elongation at break 33%, and bending modulus is
3517Mpa, notch impact strength are 7 kJ/m2。
Embodiment 2：
1. it weighs γ-(2,3- the third oxygen of epoxy) propyl trimethoxy silicane 12g, nanometer hydroxyapatite 600g to place it in
The mixed solution high speed shearing of 10L second alcohol and waters is scattered, and wherein the volume ratio of second alcohol and water is 2：8, shearing rate of dispersion is
800r/min, disperse 6 it is small when after add in 600g polyether-ether-ketone powder, continue disperse 2 hours after filter, the blend that will be obtained
It is placed in 160 DEG C of baking oven and is dried, drying time 16h；
2. obtained pre-composition is added in milling apparatus, grinding rate 800r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 800g）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 370 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 146Mpa, bending strength 182Mpa, elongation at break 29%, and bending modulus is
3000Mpa, notch impact strength are 6.9 kJ/m2。
Embodiment 3：
1. weighing γ-chloropropyl triethoxysilane 3g, nano-titanium dioxide 300g places it in the mixing of 10L second alcohol and waters
The shearing of solution high speed is scattered, and wherein the volume ratio of second alcohol and water is 4：6, shearing rate of dispersion be 400r/min, disperse 9 it is small when
800g polyether-ether-ketone powder is added in afterwards, is continued to filter after disperseing 3 hours, obtained blend is placed in 160 DEG C of baking oven
It is dried, drying time 18h；
2. obtained pre-composition is added in milling apparatus, grinding rate 1200r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 900g）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 360 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 152Mpa, bending strength 189Mpa, elongation at break 27%, and bending modulus is
3127Mpa, notch impact strength are 7.7 kJ/m2。
Embodiment 4
1. weighing γ-chloropropyl triethoxysilane 45g, nanometer hydroxyapatite 900g, the mixed of 10L second alcohol and waters is placed it in
It is scattered to close the shearing of solution high speed, wherein the volume ratio of second alcohol and water is 3：7, shearing rate of dispersion is 600r/min, and it is small to disperse 7
When after add in 1000g polyether-ether-ketone powder, continue disperse 1 hour after filter, obtained blend is placed in 160 DEG C of baking oven
In dried, drying time 18h；
2. obtained pre-composition is added in milling apparatus, grinding rate 1500r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 100g）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 330 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 144Mpa, bending strength 173Mpa, elongation at break 31%, and bending modulus is
3260Mpa, notch impact strength are 7.5 kJ/m2。
Embodiment 5：
1. weighing γ-(2,3- the third oxygen of epoxy) propyl trimethoxy silicane 21g, nanometer fluor-apatite 700g places it in 10L
The mixed solution high speed shearing of second alcohol and water is scattered, and wherein the volume ratio of second alcohol and water is 2：8, shearing rate of dispersion is
800r/min, disperse 6 it is small when after add in 600g polyether-ether-ketone powder, continue disperse 2 hours after filter, the blend that will be obtained
It is placed in 160 DEG C of baking oven and is dried, drying time 16h；
2. obtained pre-composition is added in milling apparatus, grinding rate 800r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 700g）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 370 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 129Mpa, bending strength 177Mpa, elongation at break 33%, and bending modulus is
3466Mpa, notch impact strength are 6.8 kJ/m2。
Embodiment 6：
1. weighing γ-(2,3- the third oxygen of epoxy) propyl trimethoxy silicane 20g, nano-titanium dioxide 500g places it in 10L
The mixed solution high speed shearing of second alcohol and water is scattered, and wherein the volume ratio of second alcohol and water is 1：9, shearing rate of dispersion is
800r/min, disperse 6 it is small when after add in 600g polyether-ether-ketone powder, continue disperse 2 hours after filter, the blend that will be obtained
It is placed in 160 DEG C of baking oven and is dried, drying time 16h；
2. obtained pre-composition is added in milling apparatus, grinding rate 800r/min, milling time 15min；
3. obtained blend and remaining polyether-ether-ketone powder will be ground（That is 900g）It is placed in homogenizer and is blended, during stirring
Between be 15min, stir speed (S.S.) 1200r/min；
It is squeezed out 4. the blend of above-mentioned steps is placed in extruder, extrusion equipment is double screw extruder, extrusion temperature
For 370 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
Tensile strength reaches 138Mpa, bending strength 180Mpa, elongation at break 30%, and bending modulus is
3246Mpa, notch impact strength are 7.2 kJ/m2。
Claims (5)
1. a kind of preparation method of medical grade modified polyetheretherketonefiber, includes the following steps：
1）It is according to mass ratio by coupling agent, nano material: 0.01~0.1：1 ratio weighs, and is placed in the mixing of second alcohol and water
The shearing of solution high speed is scattered, wherein, the volume ratio of second alcohol and water is 1：9~9:1, shearing rate of dispersion is 400 ~ 1200r/
Min, disperse 1 ~ 9 it is small when after add in polyether-ether-ketone powder, wherein, the mass ratio of polyether-ether-ketone powder and nano material is 1 ~ 3:1,
Continue to filter after disperseing 1 ~ 5 hour, obtained pre-composition is placed in 150 DEG C ~ 160 DEG C of baking oven and is dried, during drying
Between for 8 ~ for 24 hours；
2）Obtained pre-composition is added in milling apparatus be ground it is scattered, grinding rate be 800 ~ 2000r/min, grinding
Time is 5min ~ 20min；
3）The blend that grinding obtains is placed in remaining polyether-ether-ketone powder in homogenizer and is blended, mixing time 5min
~ 20min, stir speed (S.S.) are 800 ~ 1500r/min；
4）The blend of above-mentioned steps is placed in extruder and is squeezed out, extrusion equipment is double screw extruder, extrusion temperature
For 330 ~ 420 DEG C, the type of cooling obtains product using air-cooled after pelletizing.
2. a kind of preparation method of medical grade modified polyetheretherketonefiber according to claim 1, it is characterised in that：
The high temperature resistant coupling agent of addition is γ-chloropropyl triethoxysilane, γ-(the third oxygen of 2,3- epoxies) propyl trimethoxy
One kind in silane.
3. a kind of preparation method of medical grade modified polyetheretherketonefiber according to claim 1, it is characterised in that：
The nano material of addition is hydroxyapatite（HA）, nanometer fluor-apatite, one kind in nano-titanium dioxide.
4. a kind of preparation method of medical grade modified polyetheretherketonefiber according to claim 1, it is characterised in that：What is added in is resistance to
High temperature coupling agent and the mass ratio of nano material are 0.1:10~0.6:10.
5. a kind of preparation method of medical grade modified polyetheretherketonefiber according to claim 1, it is characterised in that：
The nano material of addition and the mass ratio of polyether-ether-ketone are 1:9~5:5.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110152068A (en) * | 2019-05-31 | 2019-08-23 | 武汉理工大学 | A kind of polyether-ether-ketone/nano hydroxyapatite composite material and its preparation method and application |
| CN110339402A (en) * | 2019-07-29 | 2019-10-18 | 武汉理工大学 | The polyether-ether-ketone Biocomposite material and preparation method thereof of α phase nano aluminium oxide enhancing |
| CN111499955A (en) * | 2020-06-01 | 2020-08-07 | 南方医科大学第三附属医院（广东省骨科研究院） | Stretcher suitable for radiation environment |
| CN113877003A (en) * | 2021-10-19 | 2022-01-04 | 吉林省中研高分子材料股份有限公司 | Medical-grade composite material and preparation method thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101879332A (en) * | 2010-07-13 | 2010-11-10 | 北京大学 | Polyether-ether-ketone composite material containing fluorapatite and titanium dioxide and preparation method thereof |
| CN101899193A (en) * | 2010-07-09 | 2010-12-01 | 华东理工大学 | Polyether-ether-ketone composite material containing fluorine phosphorus lime, preparation method and usage thereof |
| CN104788896A (en) * | 2015-04-27 | 2015-07-22 | 吉林省中研高性能工程塑料股份有限公司 | Anti-static polyether-ether-ketone composite and preparation method thereof |
| CN104974467A (en) * | 2015-07-23 | 2015-10-14 | 深圳市科聚新材料有限公司 | Nano-hydroxyapatite/polyether-ether-ketone composite material and bone repair body as well as preparation method and application thereof |
| CN105061989A (en) * | 2015-09-02 | 2015-11-18 | 广东银禧科技股份有限公司 | Polyetheretherketone/nano-hydroxyapatite composite for SLS technology and preparation method of polyetheretherketone/nano-hydroxyapatite composite |
| CN106751444A (en) * | 2016-12-12 | 2017-05-31 | 运怡（北京）医疗器械有限公司 | A kind of preparation method of white PEEK materials |
-
2017
- 2017-12-29 CN CN201711471250.3A patent/CN108084638A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101899193A (en) * | 2010-07-09 | 2010-12-01 | 华东理工大学 | Polyether-ether-ketone composite material containing fluorine phosphorus lime, preparation method and usage thereof |
| CN101879332A (en) * | 2010-07-13 | 2010-11-10 | 北京大学 | Polyether-ether-ketone composite material containing fluorapatite and titanium dioxide and preparation method thereof |
| CN104788896A (en) * | 2015-04-27 | 2015-07-22 | 吉林省中研高性能工程塑料股份有限公司 | Anti-static polyether-ether-ketone composite and preparation method thereof |
| CN104974467A (en) * | 2015-07-23 | 2015-10-14 | 深圳市科聚新材料有限公司 | Nano-hydroxyapatite/polyether-ether-ketone composite material and bone repair body as well as preparation method and application thereof |
| CN105061989A (en) * | 2015-09-02 | 2015-11-18 | 广东银禧科技股份有限公司 | Polyetheretherketone/nano-hydroxyapatite composite for SLS technology and preparation method of polyetheretherketone/nano-hydroxyapatite composite |
| CN106751444A (en) * | 2016-12-12 | 2017-05-31 | 运怡（北京）医疗器械有限公司 | A kind of preparation method of white PEEK materials |
Non-Patent Citations (1)
| Title |
|---|
| 于守武等: "《高分子材料改性-原理及技术》", 31 May 2015, 知识产权出版社 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110152068A (en) * | 2019-05-31 | 2019-08-23 | 武汉理工大学 | A kind of polyether-ether-ketone/nano hydroxyapatite composite material and its preparation method and application |
| CN110339402A (en) * | 2019-07-29 | 2019-10-18 | 武汉理工大学 | The polyether-ether-ketone Biocomposite material and preparation method thereof of α phase nano aluminium oxide enhancing |
| CN110339402B (en) * | 2019-07-29 | 2021-11-23 | 武汉理工大学 | Alpha-phase nano-alumina reinforced polyetheretherketone biological composite material and preparation method thereof |
| CN111499955A (en) * | 2020-06-01 | 2020-08-07 | 南方医科大学第三附属医院（广东省骨科研究院） | Stretcher suitable for radiation environment |
| CN113877003A (en) * | 2021-10-19 | 2022-01-04 | 吉林省中研高分子材料股份有限公司 | Medical-grade composite material and preparation method thereof |
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Application publication date: 20180529 |