CN105012889A - Composition for treating cervical cancer and preparing method thereof - Google Patents
Composition for treating cervical cancer and preparing method thereof Download PDFInfo
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Abstract
The invention discloses a composition for treating cervical cancer. The composition is prepared from, by weight, 8-15 parts of curcuma zedoary, 10-14 parts of petra volubilis, 7-13 parts of dysosma versipellis, 9-15 parts of roots of Chinese pulsatilla, 10-16 parts of mountain ebony, 8-14 parts of wang jiangqing, 11-15 parts of carrots, 9-14 parts of luxincao, 7-16 parts of lactuca indica, 12-18 parts of semen coicis, 8-13 parts of stachys sieboldi miq, 6-15 parts of scandent schefflera stems and leaves, 9-12 parts of solanum vine, 7-14 parts of kelp and 9-16 parts of sculellaria barbata. The composition has the advantages that medicine supplements each other, the composition has very high effects of invigorating qi to strengthen superficies, relieving swelling and clearing away toxic materials and has remarkable effect on treating the advanced cervical carcinoma as well as the cervical carcinoma at the early state; the composition is based on the principle of strengthening the body resistance to eliminate pathogenic factors and scientific in matching, has the functions of clearing away heat and toxic materials, relieving the swelling and removing stasis and is capable of suppressing tumor growth obviously, improving the constitution of patients and improving the body immune function remarkably.
Description
Technical field
The present invention relates to traditional Chinese medicine field, particularly relate to a kind of compositions and the method for making of curing cervical cancer.
Background technology
Cervical cancer refers to the malignant tumor of the columnar epithelial cell intersection of squamous cell and the neck tube inner membrance occurring in ectocervical or transitional zone, accounts for more than 50% of female reproductive system malignant tumor, is one of modal malignant tumor of women.Its sickness rate is only second to breast carcinoma.According to data statistics, the annual new cases of cervical cancer sent out in the whole world, greatly about about 500,000, wherein 80% occurs in developing country.Cases of cervical cancer more than 130,000 is newly sent out every year by China, accounts for greatly the world and newly sends out 1/3rd of cases of cervical cancer every year, and this is very high numeral.Investigation finds, the women of each age level all can suffer from cervical cancer, and its sickness rate significantly rises with the growth at age.
The traditional Chinese medical science thinks that primary disease belongs to the category of " metrorrhagia ", " coloured vaginal discharge ", " abdominal mass is gathered ".As "Nei Jing" is recorded " conception vessel is disease, and woman's leukorrhagia abdominal mass is gathered "; " dai channel is not solid, thus leukorrhagia for lid Chong and Ren channel disorder, governor vessel mistake department "." Complete Effective Prescriptions for Women " cloud: " puerperal, vim and vigour were hindered in internal organs, and internal organs weakness is taken advantage of by air-cooled, fights in internal organs, ties mutually in QI and blood, therefore becomes to gather block also." therefore primary disease mainly due to puerperal through row accidentally; invade in the heresy that wind and cold is damp and hot; or seven emotions diet internal injury, cause function not normal, disorder of QI and blood; the impairment of chong and ren channels; the tangible heresy such as congestion, phlegm retention, noxious dampness in succession in raw, in lower abdomen of being detained, born of the same parents, punching appoints, and long-pending knot is not understood with the passing of time gradually to become; especially relevant not note menstrual period in puerperal taking good care of oneself, and marry too early, premature labor, fecund and sexual life disorderly be also cause tumorigenic major reason.
Application publication number CN102671129A(application number 201210158263.6) Chinese invention patent document disclose a kind of Chinese medicine composition for the treatment of cervical cancer, be made up of the raw material of following weight: Herba Patriniae 30 grams, Flos Lonicerae 20 grams, Spica Prunellae 30 grams, 15 grams, Pericarpium Citri Reticulatae Viride, Ramulus Cinnamomi 9 grams, 15 grams, Poria, Olibanum 15 grams, Semen Coicis 15 grams, Myrrha 6 grams, Cortex Moutan 6 grams, Cortex Phellodendri 10 grams, Radix Paeoniae Rubra 15 grams, Rhizoma Curcumae 20 grams, Rhizoma Coptidis 20 grams, Radix Scutellariae 15 grams, 15 grams, Flos Carthami, 15 grams, Semen Persicae.Application publication number CN103611094A(application number 201310673190.9) Chinese invention patent document disclose a kind of medicine for the treatment of cervical cancer, , be made up of the crude drug of following weight: Radix Codonopsis 25 grams, Ganoderma 10 grams, the Radix Astragali 15 grams, Radix Rehmanniae Preparata 15 grams, Fructus Schisandrae Chinensis 15 grams, Radix Angelicae Sinensis 20 grams, Caulis Spatholobi 20 grams, Herba Hedyotidis Diffusae 20 grams, Herba Houttuyniae 15 grams, Fructus Bruceae 15 grams, Radix Sophorae Tonkinensis 15 grams, Flos Lonicerae 20 grams, 20 grams, Poria, Fructus Ligustri Lucidi 20 grams, Cortex Moutan 15 grams, Radix Paeoniae Rubra 15 grams, Herba Dendrobii 15 grams, 25 grams, Flos Carthami, Rhizoma Curcumae 20 grams, Radix Scutellariae 15 grams, the Rhizoma Anemarrhenae 15 grams, Endothelium Corneum Gigeriae Galli 15 grams, Herba Patriniae 15 grams, Radix Bupleuri 20 grams, Fructus Lycii 15 grams, Fructus Citri 10 grams, Pericarpium Citri Reticulatae 15 grams, the Radix Aucklandiae 15 grams, Squama Manis 15 grams, 3 grams, Radix Glycyrrhizae.Application publication number CN103656041A(application number 201310674302.2) Chinese invention patent document disclose a kind of Chinese medicine for the treatment of cervical cancer, be made up of the crude drug of following weight: Flos Sophorae (parched) 20 grams, Spica Prunellae 20 grams, Herba Scutellariae Barbatae 20 grams, Herba Hedyotidis Diffusae 20 grams, 15 grams, Pericarpium Citri Reticulatae Viride, Cortex Moutan 15 grams, 15 grams, Semen Persicae, the Radix Paeoniae Alba 15 grams, Carapax Trionycis 15 grams, Rhizoma Cyperi 15 grams, 15 grams, Poria, Cortex Phellodendri 15 grams, Ramulus Cinnamomi 10 grams, Radix Angelicae Sinensis 10 grams, Olibanum 10 grams, Myrrha 6 grams, 5 pieces, Fructus Jujubae, Rhizoma Coptidis 10 grams, Scorpio 6 grams, Scolopendra 10g, 3 grams, Radix Glycyrrhizae.
Current doctor trained in Western medicine is mainly through operation and Radiotherapy chemotherapy treatment.Chemotherapy is used for palliative therapy in late period, and effect is undesirable; Radiotherapy effect is still satisfied but reaction is comparatively large, particularly to the late phase reaction of rectum, causes that patient has blood in stool incessantly, anemia, weakness, lethargy so that disablement.The toxic and side effects of Chinese medicine cervical cancer is relatively little, and make up western medical treatment not enough in have positive effect, also have remarkable result reducing in the relapse rate of cervical cancer, the life cycle extending patient and the life quality etc. improving patient.
Summary of the invention
For the deficiencies in the prior art, the object of this invention is to provide and a kind ofly prepare simple, taking convenience, the compositions curing cervical cancer safely and effectively and preparation method.The present composition is evident in efficacy and have no side effect, and is convenient to clinical practice.
Technical scheme of the present invention is:
Cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion: Rhizoma Curcumae 8-15; Radix seu Folium Tetracerae asiaticae 10-14; Radix et Rhizoma Dysosmatis 7-13; Radix Pulsatillae 9-15; Bauhinia purpurea 10-16; The blue or green 8-14 in Wangjiang; Radix Dauci Sativae 11-15; Cor Cervi grass 9-14; Herba Lactucae Indicae 7-16; Semen Coicis 12-18; Rhizoma Humatae Tyermanni 8-13; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6-15; Herba Solani Lyrati 9-12; Thallus Laminariae (Thallus Eckloniae) 7-14; Herba Scutellariae Barbatae 9-16.
In preferred scheme, Rhizoma Curcumae 10-13; Radix seu Folium Tetracerae asiaticae 11-13; Radix et Rhizoma Dysosmatis 9-11; Radix Pulsatillae 11-13; Bauhinia purpurea 12-14; The blue or green 10-12 in Wangjiang; Radix Dauci Sativae 12-14; Cor Cervi grass 10.5-12.5; Herba Lactucae Indicae 10-13; Semen Coicis 14-16; Rhizoma Humatae Tyermanni 9.5-11.5; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8-13; Herba Solani Lyrati 10-11; Thallus Laminariae (Thallus Eckloniae) 9-12; Herba Scutellariae Barbatae 11-14.
Be more preferably, Rhizoma Curcumae 11.5; Radix seu Folium Tetracerae asiaticae 12; Radix et Rhizoma Dysosmatis 10; The Radix Pulsatillae 12; Bauhinia purpurea 13; Wangjiang green grass or young crops 11; Radix Dauci Sativae 13; Cor Cervi grass 11.5; Herba Lactucae Indicae 11.5; Semen Coicis 15; Rhizoma Humatae Tyermanni 10.5; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10.5; Herba Solani Lyrati 10.5; Thallus Laminariae (Thallus Eckloniae) 10.5; Herba Scutellariae Barbatae 12.5.
Cure a compositions for cervical cancer, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Semen Coicis is placed in parch container, it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, mixes with Semen Coicis powder, sieves for subsequent use;
(2) cleaned by Radix Dauci Sativae, cut the thin slice of about 2cm, be placed in hot pot, add the clear water slow fire boiling 12-26 minute clear water slow fire boiling of 4 times amount (preferably add 19 minutes) of 3-5 times amount, filter, filtrate is for subsequent use;
(3) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, Radix et Rhizoma Dysosmatis, Wangjiang green grass or young crops and Rhizoma Humatae Tyermanni are placed in air drier fully dry, are then together ground into fine powder, are placed in penetrating bag, sealing, for subsequent use;
(4) Radix Pulsatillae, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in medicine pot, add cold water soak 1.5-2.5 hour the cold water soak of 7.5 times amount (preferably add 2 hours) of 6-9 times amount, then the penetrating bag of step (3) gained is added, slow fire decocts twice slowly, first time decocts 22-38 minute (preferably first time decocts 30 minutes), and second time decocts 10-20 minute (preferably second time decocts 15 minutes), merges twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (2) and step (4) gained filtrate are merged, be evaporated to 1/2 of original liquid volume, add step (1) gained mixing fine powders, stir, sterilizing, to obtain final product.
Above-mentioned a kind of decoction of curing cervical cancer, preferred scheme is, the middle 85-115 mesh sieve excessively of step (1) (preferred 95-105 mesh sieve excessively, mistake 100 mesh sieve be more preferably).
The preparation method of described pill is:
(1) cleaned by Radix Dauci Sativae, be placed in steamer, water proof steaming and decocting is put well-done, takes out, rubs into pureed, for subsequent use; Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use;
(2) by Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Wangjiang green grass or young crops, Rhizoma Humatae Tyermanni and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in hermetic container, add yellow wine and mix thoroughly, put in steamer, slow fire hot digestion is sucked to wine, and taking-up is dried, and is ground into fine powder, for subsequent use;
(3) Radix et Rhizoma Dysosmatis, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Herba Solani Lyrati, Thallus Laminariae (Thallus Eckloniae) and Herba Scutellariae Barbatae are placed in marmite, add cold water and do not have powder, intense fire is heated to boil, turn slow fire boiling twice, each respectively decoction 16-28 minute (preferably each each decoction 22 minutes), merges twice decocting liquid, filtration, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 10% sucrose fine and mass fraction be the polyvinylpolypyrrolidone of 5.5%, mixing, make the pill of Semen Phaseoli size, to obtain final product.
Above-mentioned a kind of preparation method curing the pill of cervical cancer, preferred scheme is, the 40%-50% of the amount of yellow wine to be the amount of the preferred yellow wine of 35%-55%(of raw material dose be raw material dose in step (2), and the amount of the yellow wine be more preferably is 45% of raw material dose).
The preparation method of described granule is:
(1) Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, for subsequent use;
(2) put in pot by Rhizoma Curcumae, the rice vinegar adding 20% is mixed thoroughly, vexed 3-7 minute (preferably vexed 5 minutes), then adds the clear water (preferably adding the clear water of 8%) of 6%-10%, slow fire heating is boiled and is sucked to vinegar liquid, and the white heart of medical material internal affairs, takes out section, drying, is ground into fine powder, for subsequent use;
(3) medical material except step (1) and (2) is placed in medicine pot, add clear water and decoct 35-55 minute (preferably add clear water and decoct 45 minutes), clear water amount is 3.5-4.5 times (preferred clear water amount is 4 times of raw material dose) of raw material dose, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.30-1.33, spraying dry, get dry extract powder, let cool, porphyrize, for subsequent use;
(4) the raw material medicated powder mixing after being processed step (1)-(3), cross 110-130 mesh sieve (preferred mistake 120 mesh sieve), add dextrin fine powder and cross-linked cellulose, mixing, granulate, dry, subpackage, to obtain final product.
Above-mentioned a kind of preparation method curing the granule of cervical cancer, preferred scheme is, step (4) Raw medicated powder: dextrin fine powder: cross-linked cellulose=5:1.1:0.45.
The preparation method of described powder is:
(1) Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Semen Coicis, Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in exsiccator, in 68-74 DEG C of dry 45-75 minute (being preferable over 70 DEG C of dryings 60 minutes), take out, for subsequent use;
(2) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Radix et Rhizoma Dysosmatis and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in Sucus Zingberis and mix thoroughly, take out, put in parch container, and slow fire heating stir-fries yellow to surface coke, takes out, for subsequent use;
(3) Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, together be placed in medicine pot with Wangjiang green grass or young crops, Radix Dauci Sativae and Rhizoma Humatae Tyermanni and decoct with water twice, each respectively decoction 10-24 minute (preferably each each decoction 17 minutes), filter, filtrate reduced in volume becomes thick paste, gets dry extract, cool in 85 DEG C of vacuum dryings, porphyrize, the powder that gets dry extract is for subsequent use;
(4) crude drug after step (1) and (2) process is placed in pulverizer and is ground into fine powder, mix with step (3) gained dried cream powder, cross 50-80 mesh sieve (65 sieves of preferably looking over so as to check), sterile packaged, to obtain final product.
Scientific formula of the present invention, preparation method is simple, taking convenience, Be very effective.In addition, excellent results of the present invention also shows:
1,medicine of the present invention supplements and complements each other, and has very strong invigorating QI to consolidate the body surface resistance, and effect of poison is led in detumescence, is early stage or Advanced Cervical Carcinoma all has significant therapeutic effect;
2,medicine of the present invention take strengthening vital QI to eliminate pathogenic factors as this, and proportioning science, not only has the effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, and can obviously grow by Tumor suppression, improves body, significantly improves body's immunity;
3,the present invention develops in conjunction with latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment, and all medicines share, and has evident in efficacy, safe ready, cheap feature.
The pharmacology of the present invention's main raw material of Chinese medicine used is as follows:
Rhizoma Curcumae: base is former: be the rhizome of zingiberaceous plant Rhizoma Curcumae.Chemical analysis: rhizome is containing volatile oil, and the composition contained in oil has Rhizoma Curcumae furanone, table Rhizoma Curcumae furanone, Rhizoma Curcumae furan hydrocarbon, curdione, curcumenol, Camphora, Borneolum Syntheticum etc.Nature and flavor: toil, temperature.Gui Jing: return liver, spleen channel.Function cures mainly: removing blood stasis circulation of qi promoting, removing food stagnancy pain relieving.For abdominal pain due to blood stasis, hepatosplenomegaly, trusted subordinate's distending pain, gather, women's blood stasis amenorrhea, traumatic injury is had a pain eating accumulation.(1) promoting the circulation of QI to relieve pain, removing blood stasis removing food stagnancy: for the amenorrhea of qi depression to blood stasis, chest and hypochondrium, stomachache and lump in the abdomen lump etc.Often join Rhizoma Sparganii.(2) promoting digestion and removing stagnation: for the stomach abdominal distention and pain of eating accumulation, often join Fructus Hordei Germinatus (parched to brown), Semen Arecae Prepareta.
Radix seu Folium Tetracerae asiaticae: base is former: be root or the stem and leaf of rattan when Dilleniaceae plant Radix seu Folium Tetracerae asiaticae and row leaf stannum.Chemical analysis: hair leaf Radix seu Folium Tetracerae asiaticae contains lupeol, betulin, the triterpenoid compound such as betulin and cupreol.Nature and flavor: acid; Puckery; Flat.Gui Jing: liver; Large intestine channel.Function cures mainly: arresting collape syndrome by astringents; Reducing swelling and alleviating pain.Main chronic diarrhea chronic dysentery; Have blood in stool; Proctoptosis; Seminal emission; Leucorrhea; Uterine prolapse; Treating swelling and pain by traumatic injury.
Radix et Rhizoma Dysosmatis: base is former: be rhizome and the root of Berberidaceae plant Radix et Rhizoma Dysosmatis.Chemical analysis: root and rhizome is containing podophyllotoxin, Deoxypodophyllotoxin, isopicropodophyllone, hyperin etc.Nature and flavor: bitter in the mouth; Pungent; Cool in nature; Poisonous.Gui Jing: lung; Liver Channel.Function cures mainly: change and talk eliminating stagnation; Stasis-dispelling and pain-killing; Heat-clearing and toxic substances removing.Main cough; Laryngopharynx swelling and pain; Scrofula; Goiter; Carbuncle; Furuncle; Venom; Traumatic injury harm; Arthromyodynia.
The Radix Pulsatillae: base is former: this product is the dry root of the ranunculaceae plant Radix Pulsatillae.Nature and flavor: bitter, cold.Gui Jing: return stomach, large intestine channel.Effect: heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Cure mainly: for toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.
Bauhinia purpurea: base is former: pulse family bauhinia Bauhinia purpurea, with root, bark, leaf and flower are used as medicine.Nature and flavor: root: micro-puckery are micro-cool.Bark: bitter, puckery is flat.Leaf: light is flat.Flower: light, cool.Function cures mainly: root: hemostasis, spleen invigorating.For spitting of blood, dyspepsia.Bark: the spleen strengthening and damp drying.For dyspepsia, acute gastroenteritis.Leaf: nourishing the lung to arrest cough.For cough, constipation.Flower: antiinflammatory.For pneumonia, bronchitis.
Wangjiang is blue or green: base is former: be root or the herb of labiate Stachys palustris L..Chemical analysis: Stachys palustris L. herb contains α-Amyrin, cupreol and sterol ester, green lotus ruscogenin, neochlorogenin, caffeic acid.Nature and flavor: sweet in the mouth; Bitter; Cool in nature.Gui Jing: lung meridian.Function cures mainly: heat-clearing and toxic substances removing; Removing heat from blood and promoting blood circulation.Main laryngopharynx swelling and pain; Lung abscess; Pertussis; Dysentery; Acute mastitis; Herpes zoster; The raw cataracta of order; Spitting of blood; Treating swelling and pain by traumatic injury.
Radix Dauci Sativae: base is former: be the root of samphire Radix Dauci Sativae.Chemical analysis: root containing α-, β-, γ-and ξ-carotene, Fructus Lycopersici esculenti, the multiple types carotene such as six hydrogen Fructus Lycopersici esculenti; Vitamin B1, B2 and anthocyanidin.Also sugary 3%-15%, fatty oil 0.1%-0.7%, volatile oil 0.014%, umbelliferone etc.In root, the content of volatile oil reduces with growth, and carotene carotene content then increases with growth.Containing australene in volatile oil, lauro lene, myrcene, α-phellandrene, bisabolence etc.Pharmacological action: dry Radix Dauci Sativae Petroleum ether extraction part, isolated amorphous yellow composition, is dissolved in almond oil, and being injected in people, rabbit, Canis familiaris L. all has obvious hypoglycemic activity.Nature and flavor: sweet in the mouth; Pungent; Property is put down.Gui Jing: return spleen; Liver; Lung meridian.Function cures mainly: spleen invigorating and in; Nourishing liver for improving eyesight; Preventing phlegm from forming and stopping coughing; Heat-clearing and toxic substances removing.Main insufficiency of the spleen lack of appetite; Body void is weak; Abdominal pain; Let out dysentery; Blurring of vision; Nyctalopia; Cough with asthma, pertussis; Laryngopharynx swelling and pain; Measles; Chickenpox; Furuncle and phyma; Burn; Anal fistula.
Cor Cervi grass: base is former: be the herb of the thick fringe Balaenoptera borealis Lesson of Balanophoraceae plant.Chemical analysis: be separated from Herb and obtain caffeic methyl ester, lariciresinol.Nature and flavor: bitter; Puckery; Function warm in nature cures mainly: kidney invigorating and YANG supporting; Spleen invigorating is regulated the flow of vital energy; Hemostasis.Main sexual impotence; Dysentery; Stomachache is spitted blood; Menorrhagia; Traumatic hemorrhage.
Herba Lactucae Indicae: base is former: be the herb of feverfew Herba Lactucae Indicae.Nature and flavor: herbal for Relief of Famines: " mildly bitter flavor." function cures mainly: " illustrated handbook planted by middle traditional Chinese medicines ": " stem, leaf decoction, can be antipyretic; Powder is coated with and puts on the skin, can remove wart tumor.”
Semen Coicis: base is former: be the kernel of grass Semen Coicis.Nature and flavor: sweet light, cool.Gui Jing: enter spleen, lung, kidney channel.Function cures mainly: spleen invigorating, tonifying the lung, heat clearing away, dampness removing.Control and have loose bowels, arthralgia chiefly caused by damp pathogen, the contracture of muscle arteries and veins, joint stuffiness, edema, beriberi, consumptive lung disease, lung abscess, acute appendicitis, stranguria with turbid discharge, leucorrhea.
Rhizoma Humatae Tyermanni: base is former: be tuber and the herb of labiate Rhizoma Humatae Tyermanni.Chemical analysis: aerial parts contains different high mountain knotweed a kind of reed mentioned in ancient books element-4-methyl ether-7-O-β-(6 '-O-acetyl group-2 '-allose base) glycoside, and different high mountain baicalin-7-O-β (6 '-O acetyl group-2 "-authority of office Lip river glycosyl) glycoside, Syring vulgaris phenol glycoside.Containing Herba Stachydis Japonicae glycoside in tuber.Containing lavandula angustifolia leaf Herba Stachydis Japonicae glycoside and Herba Stachydis Japonicae glycoside B in leaf, Herba Stachydis Japonicae glycoside.Herb contains stachydrine, choline, stachyose.Pharmacological action: different high mountain baicalin methyl ether-7-O-β (6 "-O-acetyl group-2 "-allose base) the glycoside 0.25mmol/L that Rhizoma Humatae Tyermanni aerial parts contains can strengthen the activation of hyaluronidase caused by calcium chloride, until 0.2mol-L is still in concentration dependant performance activation, but this effect obviously weakens when 0.5mol-L; Be concentration dependent potentiation to hyaluronidase activity under Syring vulgaris phenol glycoside 0.5mmol-L concentration; Different high mountain baicalin 7-O-β (6 "-O-acetyl group-2 "-allose base) glycoside has no potentiation completely, instead can more weak hyaluronidase inhibitor [1].Nature and flavor: sweet in the mouth; Property is put down.Gui Jing: return lung; Liver; Spleen channel.Function cures mainly: lung heat clearing of inducing sweat; Eliminating damp, detoxifying; Tonify deficiency spleen invigorating.Main anemopyretic cold; Cough due to consumptive disease; Jaundice; Stranguria; Sore swells and ache; Venom.
Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae): base is former: be root or the stem and leaf of Araliaceae schefflera arboricola.Nature and flavor: micro-hardship, temperature.Function cures mainly: expelling wind and removing dampness, promoting blood circulation and stopping pain.Dispelling the wind and dampness pathogens arthralgia pain, stomachache, injury and bone fracture, traumatic hemorrhage." the practical Chinese herbal medicine in Guangxi newly selects ": " promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, strengthening bone and muscle.Control acute rheumatic arthritis, stomachache, fracture, bruise, lumbago and skelalgia, paralysis.”
Herba Solani Lyrati: base is former: be the herb of plant of Solanaceae Herba Solani Lyrati.Nature and flavor: sweetness and bitterness, cold.Gui Jing: return liver; Gallbladder; Kidney channel.Function cures mainly: heat clearing away, and dampness removing dispels the wind, removing toxic substances.Treating malaria disease, jaundice, edema, gonorrhea, rheumatic arthritis, erysipelas, furuncle.
Thallus Laminariae (Thallus Eckloniae): base is former: be the thallus of Laminariaceae (Laminariophyceae) Larminaria plant Thallus Laminariae (Thallus Eckloniae) and the black Thallus Laminariae (Thallus Eckloniae) of Alariaceae laminaria, undaria plant Thallus Laminariae.Composition: 1.Thallus Laminariae (Thallus Eckloniae) is containing compound of polysaccharide, and mainly containing three kinds: one is alginate, is alginic acid and sodium, potassium, ammonium, calcium salt etc.; Secondly be that rock algae is according to polysaccharide; Moreover be laminarin etc.2。Black Thallus Laminariae (Thallus Eckloniae) contains alginic acid and sodium salt thereof, laminarin, mannitol, vitamin, halogenide, sulfate, phosphate, iodine and other trace element lamps.3。The full algae of Thallus Laminariae contains compound of polysaccharide, mainly alginic acid, laminarin and lipopolysaccharide etc.The property of medicine: salty, cold.Gui Jing: return liver, stomach, kidney channel.Function cures mainly: softening and eliminating sputum, inducing diuresis to remove edema.Cure mainly goiter, scrofula, swelling of the scrotum, the cancer of the esophagus, beriberi edema.
Herba Scutellariae Barbatae: base is former: be the herb of portulacaceous plant Portulaca grandilora.Chemical analysis: herb, containing portulal, is the material of coordinate plant growth.Stem and flower are containing betacyanin, and main is Radix Betae glycoside, and glycoside unit is betanidin.Nature and flavor: " Nanning City's medicine will ": " bitter, cold." function cures mainly: heat clearing away, removing toxic substances.Control laryngopharynx swelling and pain, scald, traumatic injury, eczema.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not limited thereto.
embodiment 1cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion (70g/ part): Rhizoma Curcumae 8 parts; Radix seu Folium Tetracerae asiaticae 10 parts; Radix et Rhizoma Dysosmatis 7 parts; The Radix Pulsatillae 9 parts; Bauhinia purpurea 10 parts; Blue or green 8 parts of Wangjiang; 11 parts, Radix Dauci Sativae; Cor Cervi grass 9 parts; Herba Lactucae Indicae 7 parts; Semen Coicis 12 parts; Rhizoma Humatae Tyermanni 8 parts; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6 parts; Herba Solani Lyrati 9 parts; Thallus Laminariae (Thallus Eckloniae) 7 parts; Herba Scutellariae Barbatae 9 parts.
A kind of preparation method curing the decoction of cervical cancer is:
(1) Semen Coicis is placed in parch container, it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, mixes with Semen Coicis powder, crosses 85 mesh sieves, for subsequent use;
(2) cleaned by Radix Dauci Sativae, cut the thin slice of about 2cm, be placed in hot pot, add the clear water slow fire boiling 12 minutes of 3 times amount, filter, filtrate is for subsequent use;
(3) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, Radix et Rhizoma Dysosmatis, Wangjiang green grass or young crops and Rhizoma Humatae Tyermanni are placed in air drier fully dry, are then together ground into fine powder, are placed in penetrating bag, sealing, for subsequent use;
(4) Radix Pulsatillae, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in medicine pot, add the cold water soak 1.5 hours of 6 times amount, then the penetrating bag of step (3) gained is added, slow fire decocts twice slowly, first time decocts 22 minutes, and second time decocts 10 minutes, merges twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (2) and step (4) gained filtrate are merged, be evaporated to 1/2 of original liquid volume, add step (1) gained mixing fine powders, stir, sterilizing, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 150-200mL, warmly takes, and within 30 days, is a course for the treatment of.
Model case: soup XX, female, 43 years old, Yuegongqiao people.There is lumbago, lower abdomen pendant pain symptom without obvious inducement before 2 years in patient, is diagnosed as cervical cancer early stage at certain examination in hospital local.Because hearing that operative treatment obtains tens0000, family does not have so much money yet, and she determines to abandon operative treatment, attempts traditional Chinese medical science expectant treatment.Successively once took kind traditional Chinese medical science folk prescription, but effect is all not obvious, when patient is downhearted, has friend to introduce my institute's treatment cervical cancer good effect, check medical so the phychology that patient has trial in arms comes my institute on June 13rd, 2010.Check: the abnormal discharge opeing of patient's vagina, leucorrhea be thin water sample, has abnormal flavour, with dizziness, weak, suffers from abdominal pain, abdominal distention symptom, and transvaginal spectroscopy is gone forward side by side temporary dwelling palace neck biopsy, is diagnosed as cervix uteri differentiated scale cancer.
Taking a kind of decoction of curing cervical cancer of the present embodiment gained, instructions of taking: twice daily, each 150-200mL, warmly to take, 30 days is a course for the treatment of.After treating two courses for the treatment of, patient part's symptom and sign disappear, and patient mental recovers gradually; Two courses for the treatment of of continual cure, vagina discharge opeing without exception, without the symptom such as dizzy, weak, the conscious rehabilitation of patient, exhorts that continuing medication is consolidated a course for the treatment of, follows up a case by regular visits to after half a year, and patient body is healthy, without recurring.
embodiment 2cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion (50g/ part): Rhizoma Curcumae 15 parts; Radix seu Folium Tetracerae asiaticae 14 parts; Radix et Rhizoma Dysosmatis 13 parts; The Radix Pulsatillae 15 parts; Bauhinia purpurea 16 parts; Blue or green 14 parts of Wangjiang; 15 parts, Radix Dauci Sativae; Cor Cervi grass 14 parts; Herba Lactucae Indicae 16 parts; Semen Coicis 18 parts; Rhizoma Humatae Tyermanni 13 parts; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 15 parts; Herba Solani Lyrati 12 parts; Thallus Laminariae (Thallus Eckloniae) 14 parts; Herba Scutellariae Barbatae 16 parts.
A kind of preparation method curing the pill of cervical cancer is:
(1) cleaned by Radix Dauci Sativae, be placed in steamer, water proof steaming and decocting is put well-done, takes out, rubs into pureed, for subsequent use; Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use;
(2) by Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Wangjiang green grass or young crops, Rhizoma Humatae Tyermanni and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in hermetic container, the yellow wine adding 45% raw material dose is mixed thoroughly, puts in steamer, and slow fire hot digestion is sucked to wine, and taking-up is dried, and is ground into fine powder, for subsequent use;
(3) be placed in marmite by Radix et Rhizoma Dysosmatis, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Herba Solani Lyrati, Thallus Laminariae (Thallus Eckloniae) and Herba Scutellariae Barbatae, add cold water and do not have powder, intense fire is heated to boil, turn slow fire boiling twice, each each decoction 22 minutes, merges twice decocting liquid, filter, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 10% sucrose fine and mass fraction be the polyvinylpolypyrrolidone of 5.5%, mixing, make the pill of Semen Phaseoli size, to obtain final product.
The instructions of taking of gained pill of the present invention is: taken three times a day, each 10-14 ball, and warm water takes, 30 days courses for the treatment of.
embodiment 3cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion (65g/ part): Rhizoma Curcumae 10 parts; Radix seu Folium Tetracerae asiaticae 11 parts; Radix et Rhizoma Dysosmatis 9 parts; The Radix Pulsatillae 11 parts; Bauhinia purpurea 12 parts; Blue or green 10 parts of Wangjiang; 12 parts, Radix Dauci Sativae; Cor Cervi grass 10.5 parts; Herba Lactucae Indicae 10 parts; Semen Coicis 14 parts; Rhizoma Humatae Tyermanni 9.5 parts; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8 parts; Herba Solani Lyrati 10 parts; Thallus Laminariae (Thallus Eckloniae) 9 parts; Herba Scutellariae Barbatae 11 parts.
A kind of preparation method curing the granule of cervical cancer is:
(1) Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, for subsequent use;
(2) put in pot by Rhizoma Curcumae, the rice vinegar adding 20% is mixed thoroughly, vexed 5 minutes, then adds the clear water of 8%, and slow fire heating is boiled and is sucked to vinegar liquid, and the white heart of medical material internal affairs, takes out section, dry, is ground into fine powder, for subsequent use;
(3) be placed in medicine pot by the medical material except step (1) and (2), add clear water and decoct 45 minutes, clear water amount is 4 times of raw material dose, filters, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.32, spraying dry, and get dry extract powder, let cool, porphyrize, for subsequent use;
(4) the raw material medicated powder mixing after being processed step (1)-(3), cross 120 mesh sieves, add dextrin fine powder and cross-linked cellulose (raw material medicated powder: dextrin fine powder: cross-linked cellulose=5:1.1:0.45), mixing, granulate, dry, subpackage, to obtain final product.
The instructions of taking of gained granule of the present invention is: every day three times, each 25-35g, and warm water is taken after mixing it with water, 30 days courses for the treatment of.
embodiment 4cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion (55g/ part): Rhizoma Curcumae 13 parts; Radix seu Folium Tetracerae asiaticae 13 parts; Radix et Rhizoma Dysosmatis 11 parts; The Radix Pulsatillae 13 parts; Bauhinia purpurea 14 parts; Blue or green 12 parts of Wangjiang; 14 parts, Radix Dauci Sativae; Cor Cervi grass 12.5 parts; Herba Lactucae Indicae 13 parts; Semen Coicis 16 parts; Rhizoma Humatae Tyermanni 11.5 parts; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 13 parts; Herba Solani Lyrati 11 parts; Thallus Laminariae (Thallus Eckloniae) 12 parts; Herba Scutellariae Barbatae 14 parts.
A kind of preparation method curing the powder of cervical cancer is:
(1) Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Semen Coicis, Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in exsiccator, in 70 DEG C of dryings 60 minutes, take out, for subsequent use;
(2) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Radix et Rhizoma Dysosmatis and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in Sucus Zingberis and mix thoroughly, take out, put in parch container, and slow fire heating stir-fries yellow to surface coke, takes out, for subsequent use;
(3) Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, is together placed in medicine pot decocts with water twice with Wangjiang green grass or young crops, Radix Dauci Sativae and Rhizoma Humatae Tyermanni, each each decoction 17 minutes, filter, filtrate reduced in volume becomes thick paste, gets dry extract in 85 DEG C of vacuum dryings, cool, porphyrize, the powder that gets dry extract is for subsequent use;
(4) crude drug after step (1) and (2) process is placed in pulverizer and is ground into fine powder, mix with step (3) gained dried cream powder, cross 65 sieves, sterile packaged, to obtain final product.
The instructions of taking of gained powder of the present invention is: every day three times, each 10-15g, is decocted in water for oral dose, 30 days courses for the treatment of.
Model case: king XX, female, 22 years old, people from Heze.Occur that intermenstrual period vagina has symptom of bleeding on a small quantity before patient half a year is many, do not pay attention at that time, as long as think what work and rest rule reasonable diet symptom were bound to eliminate.But after three months, symptom continues to have no improvement, and now Mrs Wang strikes fear into, and be diagnosed as metrorrhagia to certain examination in hospital, and give Drug therapy, treatment is had no result always.Be illustrated in through colleague and carry out my institute's inspection treatment on April 20th, 2012.Check: patient's portio supravaginalis visible about 5cm swells thing, the low echo focus of ultrasonic prompting cervical orifice, hysteroscopy is shown in that cervix uteri loses normal appearance, for evagination tuberosity occupies, diameter is about 5cm, and toner is red, the visible blood vessel thick in a large number in surface, posterior fornix shoals, and is diagnosed as adenocarcinoma of the uterine cervix through biopsy.
Take a kind of powder of curing cervical cancer of the present embodiment gained, instructions of taking: every day three times, each 10-15g, is decocted in water for oral dose, 30 days courses for the treatment of.After treating two courses for the treatment of, check and find that on vagina, swollen thing obviously reduces, cervix uteri tuberosity bounces back; Two courses for the treatment of of continual cure, patients symptomatic disappears substantially, and body constitution improves, conscious recovery from illness.Period in a medicine is without any untoward reaction.Drug withdrawal is paid a return visit after half a year, without recurrence.
embodiment 5cure a compositions for cervical cancer, be prepared from by following bulk drugs, be weight portion (60g/ part): Rhizoma Curcumae 11.5 parts; Radix seu Folium Tetracerae asiaticae 12 parts; Radix et Rhizoma Dysosmatis 10 parts; The Radix Pulsatillae 12 parts; Bauhinia purpurea 13 parts; Blue or green 11 parts of Wangjiang; 13 parts, Radix Dauci Sativae; Cor Cervi grass 11.5 parts; Herba Lactucae Indicae 11.5 parts; Semen Coicis 15 parts; Rhizoma Humatae Tyermanni 10.5 parts; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10.5 parts; Herba Solani Lyrati 10.5 parts; Thallus Laminariae (Thallus Eckloniae) 10.5 parts; Herba Scutellariae Barbatae 12.5 parts.
A kind of preparation method curing the decoction of cervical cancer is:
(1) Semen Coicis is placed in parch container, it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, mixes with Semen Coicis powder, crosses 100 mesh sieves, for subsequent use;
(2) cleaned by Radix Dauci Sativae, cut the thin slice of about 2cm, be placed in hot pot, add the clear water slow fire boiling 19 minutes of 4 times amount, filter, filtrate is for subsequent use;
(3) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, Radix et Rhizoma Dysosmatis, Wangjiang green grass or young crops and Rhizoma Humatae Tyermanni are placed in air drier fully dry, are then together ground into fine powder, are placed in penetrating bag, sealing, for subsequent use;
(4) Radix Pulsatillae, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in medicine pot, add the cold water soak 2 hours of 7.5 times amount, then the penetrating bag of step (3) gained is added, slow fire decocts twice slowly, first time decocts 30 minutes, and second time decocts 15 minutes, merges twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (2) and step (4) gained filtrate are merged, be evaporated to 1/2 of original liquid volume, add step (1) gained mixing fine powders, stir, sterilizing, to obtain final product.
The instructions of taking of gained decoction of the present invention is: twice daily, each 150-200mL, warmly takes, and within 30 days, is a course for the treatment of.
test example 1a kind of clinical practice of curing the compositions (embodiment 5) of cervical cancer of gained of the present invention:
1 data and method
1.1 physical data
In March ,-2014 in March, 2010, screen 330 routine cervical cancer patients in the oncology outpatient service of 4 hospitals, in all patients oldest 72 years old, minimum 33 years old of age, 54.5 ± 3.5 years old mean age.All patients all clarify a diagnosis as cervical cancer through pathology or cytology.
1.2 Therapeutic Method
All patients are divided into experimental group and matched group at random, and two groups of patients, in the state of an illness, age etc., through statistical procedures no significant difference (P > 0.05), have comparability.Wherein experimental group takes gained medicine of the present invention, instructions of taking: twice daily, each 150-200mL, warmly takes, and within 30 days, is a course for the treatment of.Observe four courses for the treatment of of treatment altogether.Matched group uses other drug (as medicines such as XIAOAIPING PIAN, KANGLAITE soft capsule and palace tumor Yiganning capsules).
1.3 curative effect determinate standard
Solid tumor Objective evaluation standard according to WHO is divided into:
Complete incidence graph (CR): all lesions visible disappear completely and at least maintain more than 4 weeks;
Partial rcsponse (PR): the maximum diameter of tumor focus and the product in maximum perpendicular footpath thereof reduce more than 50%, maintain more than 4 weeks;
Take a turn for the better (MR): two footpath products of tumor focus reduce more than 25%, but < 50%, occur without new focus;
Stable (SD): tumor focus two footpath product reduces < 25%, or increase < 25%, occur without new focus;
Progress (PD): tumor focus two footpath product increases > 25%, or occurs new focus.
Effective percentage=complete remission rate+partial rcsponse rate+improvement rate.
Coefficient of stabilization=complete remission rate+partial rcsponse rate+improvement rate+coefficient of stabilization.
1.4 therapeutic outcome
Table 1: the therapeutic effect of experimental group and matched group patient compares
Therapeutic effect: experimental group complete incidence graph 132 example (61.4%), partial rcsponse 47 example (21.8%), 26 examples that take a turn for the better (12.1%), stablize 8 examples (3.8%), are in progress 2 examples (0.9%), and effective percentage is 95.3%, and coefficient of stabilization is 99.1%.As can be seen from experimental result, the therapeutic effect of experimental group is obviously better than matched group.
The present invention selects the totally 15 taste primary raw material medicine scientific compatibility such as Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, Radix et Rhizoma Dysosmatis, the Radix Pulsatillae, Bauhinia purpurea, Wangjiang green grass or young crops, Radix Dauci Sativae, Cor Cervi grass, Herba Lactucae Indicae, Semen Coicis and Rhizoma Humatae Tyermanni.Fang Zhong, Rhizoma Curcumae has promoting the circulation of QI to relieve pain, the effect of removing blood stasis removing food stagnancy; Radix seu Folium Tetracerae asiaticae arresting collape syndrome by astringents, reducing swelling and alleviating pain; Radix et Rhizoma Dysosmatis stasis-dispelling and pain-killing, heat-clearing and toxic substances removing; The blue or green heat-clearing and toxic substances removing in Wangjiang, removing heat from blood and promoting blood circulation; Radix Dauci Sativae spleen invigorating and in, heat-clearing and toxic substances removing; Rhizoma Humatae Tyermanni eliminating damp, detoxifying, tonify deficiency spleen invigorating; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) promoting the circulation of QI to relieve pain, promoting blood circulation and detumescence, strengthening bone and muscle.All medicines share, and play the merit of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds altogether.After treating four courses for the treatment of, experimental group effective percentage is 95.3%, and matched group is only 72.2%.
It should be pointed out that detailed description of the invention is the more representational example of the present invention, obvious technical scheme of the present invention is not limited to above-described embodiment, can also have a lot of distortion.Those of ordinary skill in the art, with the present invention clear and definite disclosed or according to undoubted the obtaining of the written description of file, the claimed scope of this patent all should be thought.
Claims (10)
1. cure a compositions for cervical cancer, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Rhizoma Curcumae 8-15; Radix seu Folium Tetracerae asiaticae 10-14; Radix et Rhizoma Dysosmatis 7-13; Radix Pulsatillae 9-15; Bauhinia purpurea 10-16; The blue or green 8-14 in Wangjiang; Radix Dauci Sativae 11-15; Cor Cervi grass 9-14; Herba Lactucae Indicae 7-16; Semen Coicis 12-18; Rhizoma Humatae Tyermanni 8-13; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 6-15; Herba Solani Lyrati 9-12; Thallus Laminariae (Thallus Eckloniae) 7-14; Herba Scutellariae Barbatae 9-16.
2., as right wants a kind of compositions curing cervical cancer as described in 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Rhizoma Curcumae 10-13; Radix seu Folium Tetracerae asiaticae 11-13; Radix et Rhizoma Dysosmatis 9-11; Radix Pulsatillae 11-13; Bauhinia purpurea 12-14; The blue or green 10-12 in Wangjiang; Radix Dauci Sativae 12-14; Cor Cervi grass 10.5-12.5; Herba Lactucae Indicae 10-13; Semen Coicis 14-16; Rhizoma Humatae Tyermanni 9.5-11.5; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 8-13; Herba Solani Lyrati 10-11; Thallus Laminariae (Thallus Eckloniae) 9-12; Herba Scutellariae Barbatae 11-14.
3., as right wants a kind of compositions curing cervical cancer as described in 1, it is characterized in that, be prepared from by following bulk drugs, be weight portion: Rhizoma Curcumae 11.5; Radix seu Folium Tetracerae asiaticae 12; Radix et Rhizoma Dysosmatis 10; The Radix Pulsatillae 12; Bauhinia purpurea 13; Wangjiang green grass or young crops 11; Radix Dauci Sativae 13; Cor Cervi grass 11.5; Herba Lactucae Indicae 11.5; Semen Coicis 15; Rhizoma Humatae Tyermanni 10.5; Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) 10.5; Herba Solani Lyrati 10.5; Thallus Laminariae (Thallus Eckloniae) 10.5; Herba Scutellariae Barbatae 12.5.
4., as right wants a kind of compositions curing cervical cancer as described in 1-3, it is characterized in that, be made into pharmaceutically acceptable decoction, preparation method is as follows:
(1) Semen Coicis is placed in parch container, it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, mixes with Semen Coicis powder, sieves for subsequent use;
(2) cleaned by Radix Dauci Sativae, cut the thin slice of about 2cm, be placed in hot pot, add the clear water slow fire boiling 12-26 minute clear water slow fire boiling of 4 times amount (preferably add 19 minutes) of 3-5 times amount, filter, filtrate is for subsequent use;
(3) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, Radix et Rhizoma Dysosmatis, Wangjiang green grass or young crops and Rhizoma Humatae Tyermanni are placed in air drier fully dry, are then together ground into fine powder, are placed in penetrating bag, sealing, for subsequent use;
(4) Radix Pulsatillae, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae), Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in medicine pot, add cold water soak 1.5-2.5 hour the cold water soak of 7.5 times amount (preferably add 2 hours) of 6-9 times amount, then the penetrating bag of step (3) gained is added, slow fire decocts twice slowly, first time decocts 22-38 minute (preferably first time decocts 30 minutes), and second time decocts 10-20 minute (preferably second time decocts 15 minutes), merges twice decocting liquid, filter, filtrate is for subsequent use;
(5) step (2) and step (4) gained filtrate are merged, be evaporated to 1/2 of original liquid volume, add step (1) gained mixing fine powders, stir, sterilizing, to obtain final product.
5. a kind of decoction of curing cervical cancer according to claim 4, is characterized in that, the middle 85-115 mesh sieve excessively of step (1) (preferred 95-105 mesh sieve excessively, mistake 100 mesh sieve be more preferably).
6., as right wants a kind of compositions curing cervical cancer as described in 1-3, it is characterized in that, be made into pharmaceutically acceptable pill, preparation method is as follows:
(1) cleaned by Radix Dauci Sativae, be placed in steamer, water proof steaming and decocting is put well-done, takes out, rubs into pureed, for subsequent use; Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use;
(2) by Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Wangjiang green grass or young crops, Rhizoma Humatae Tyermanni and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in hermetic container, add yellow wine and mix thoroughly, put in steamer, slow fire hot digestion is sucked to wine, and taking-up is dried, and is ground into fine powder, for subsequent use;
(3) Radix et Rhizoma Dysosmatis, Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Herba Solani Lyrati, Thallus Laminariae (Thallus Eckloniae) and Herba Scutellariae Barbatae are placed in marmite, add cold water and do not have powder, intense fire is heated to boil, turn slow fire boiling twice, each respectively decoction 16-28 minute (preferably each each decoction 22 minutes), merges twice decocting liquid, filtration, filtrate reduced in volume becomes thick paste, for subsequent use;
(4) by step (1) and (2) process after crude drug join in above-mentioned thick paste, mechanical agitation, add while stirring mass fraction be 10% sucrose fine and mass fraction be the polyvinylpolypyrrolidone of 5.5%, mixing, make the pill of Semen Phaseoli size, to obtain final product.
7. a kind of preparation method curing the pill of cervical cancer according to claim 6, it is characterized in that, the 40%-50% of the amount of yellow wine to be the amount of the preferred yellow wine of 35%-55%(of raw material dose be raw material dose in step (2), the amount of the yellow wine be more preferably is 45% of raw material dose).
8., as right wants a kind of compositions curing cervical cancer as described in 1-3, it is characterized in that, be made into pharmaceutically acceptable granule, preparation method is as follows:
(1) Semen Coicis is placed in parch container, and it is degree that intense fire heating stir-fries to yellow fast, and taking-up cools, and is ground into fine powder, for subsequent use; Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, and put in hot pot, slow fire dries, and cools, and grinds into powder, for subsequent use;
(2) put in pot by Rhizoma Curcumae, the rice vinegar adding 20% is mixed thoroughly, vexed 3-7 minute (preferably vexed 5 minutes), then adds the clear water (preferably adding the clear water of 8%) of 6%-10%, slow fire heating is boiled and is sucked to vinegar liquid, and the white heart of medical material internal affairs, takes out section, drying, is ground into fine powder, for subsequent use;
(3) medical material except step (1) and (2) is placed in medicine pot, add clear water and decoct 35-55 minute (preferably add clear water and decoct 45 minutes), clear water amount is 3.5-4.5 times (preferred clear water amount is 4 times of raw material dose) of raw material dose, filter, filtrate reduced in volume to 80 DEG C relative density is the thick paste of 1.30-1.33, spraying dry, get dry extract powder, let cool, porphyrize, for subsequent use;
(4) the raw material medicated powder mixing after being processed step (1)-(3), cross 110-130 mesh sieve (preferred mistake 120 mesh sieve), add dextrin fine powder and cross-linked cellulose, mixing, granulate, dry, subpackage, to obtain final product.
9. a kind of preparation method curing the granule of cervical cancer according to claim 8, is characterized in that, step (4) Raw medicated powder: dextrin fine powder: cross-linked cellulose=5:1.1:0.45.
10., as right wants a kind of compositions curing cervical cancer as described in 1-3, it is characterized in that, be made into pharmaceutically acceptable powder, preparation method is as follows:
(1) Bauhinia purpurea, Cor Cervi grass, Herba Lactucae Indicae, Semen Coicis, Herba Solani Lyrati and Herba Scutellariae Barbatae are placed in exsiccator, in 68-74 DEG C of dry 45-75 minute (being preferable over 70 DEG C of dryings 60 minutes), take out, for subsequent use;
(2) Rhizoma Curcumae, Radix seu Folium Tetracerae asiaticae, the Radix Pulsatillae, Radix et Rhizoma Dysosmatis and Radix Schefflerae Arboricolae (Caulis et Folium Schefflerae Arboricolae) mixing, be placed in Sucus Zingberis and mix thoroughly, take out, put in parch container, and slow fire heating stir-fries yellow to surface coke, takes out, for subsequent use;
(3) Thallus Laminariae (Thallus Eckloniae) clear water washes away salty juice, together be placed in medicine pot with Wangjiang green grass or young crops, Radix Dauci Sativae and Rhizoma Humatae Tyermanni and decoct with water twice, each respectively decoction 10-24 minute (preferably each each decoction 17 minutes), filter, filtrate reduced in volume becomes thick paste, gets dry extract, cool in 85 DEG C of vacuum dryings, porphyrize, the powder that gets dry extract is for subsequent use;
(4) crude drug after step (1) and (2) process is placed in pulverizer and is ground into fine powder, mix with step (3) gained dried cream powder, cross 50-80 mesh sieve (65 sieves of preferably looking over so as to check), sterile packaged, to obtain final product.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228310A (en) * | 1998-03-09 | 1999-09-15 | 张富永 | Xiaoaisan powder for curing cancer |
| CN1679769A (en) * | 2005-01-04 | 2005-10-12 | 高和平 | Chinese medicine composition for treating cancer |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1228310A (en) * | 1998-03-09 | 1999-09-15 | 张富永 | Xiaoaisan powder for curing cancer |
| CN1679769A (en) * | 2005-01-04 | 2005-10-12 | 高和平 | Chinese medicine composition for treating cancer |
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| Title |
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| 司富春等: "治疗子宫颈癌中医方药分析", 《中医研究》 * |
| 杨建宇等主编: "《一本书读懂中草药抗癌》", 31 August 2014 * |
| 王昃睿等主编: "《名老中医王治强临床经验荟萃》", 30 June 2015 * |
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Application publication date: 20151104 |