CN105012703A - Traditional Chinese medicine for treating qi-deficiency and blood-stasis type bronchiectasis associated with hemoptysis - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine for treating qi-deficiency and blood-stasis type bronchiectasis associated with hemoptysis. The traditional Chinese medicine comprises the following traditional Chinese medicinal materials in parts by weight: 8-16 parts of ginseng, 8-16 parts of astragalus membranaceus, 11-19 parts of Chinese yam, 8-16 parts of lysimachia barystachys, 5-13 parts of smilax riparia, 5-13 parts of radix rubiae, 5-13 parts of pseudo-ginseng, 5-13 parts of oyster plant leaves, 5-13 parts of rhizoma bletillae, 5-13 parts of callicarpa bodinieri, 5-13 parts of lysimachia longipes, 8-16 parts of ligusticum wallichii, 8-16 parts of sarcococca hookeriana and 4-8 parts of liquorice. The traditional Chinese medicine has the effects of relieving the traditional Chinese medical signs and symptoms of patients obviously and achieves good clinical effects.

Description

A kind of Chinese medicine for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis.

Background technology

Respiratory system disease is the commonly encountered diseases of serious harm human health, and under the impact of smoking and other environmental factors, relevant disease also rises year by year, one of hemoptysis caused by bronchiectasis treatment difficult problem being still modern medicine.Wherein Qi deficiency blood stasis type hemoptysis caused by bronchiectasis is the common type of hemoptysis caused by bronchiectasis.Usually said apoplexy due to phlegm folder blood, in fact refers to a small amount of hemoptysis or bloody sputum.Hemoptysis Qian Changxianyou throat itches or excitement, then hemoptysis or bloody sputum, and color is scarlet, or in blister, normal mixed with light liquid phase.When hemoptysis is few, often apoplexy due to phlegm presss from both sides blood.Bronchiectasis refer to one or more bronchus vessel wall damage formed lumen distention or the not normal chronic bronchial purulent disease of distortion normally due to childhood period the result that is often infected, a few peoples cause due to the congenital abnormal development of bronchus and some inherited genetic factors.Bronchiectasis last the several years long afterwards, it can cause secreted by bronchial epithelial cells fluid removal difficulty, liquid is stayed in lung, becomes hydrops and causes further infection.

The treatment of doctor trained in Western medicine is still essential therapeutic arsenals with surgical operation, and for the person that is not suitable for operative treatment with medical treatment, but the therapeutic effect of Western medicine is desirable not to the utmost, and the course for the treatment of, length was difficult to the object reaching long-term treatment and prevention again.Therefore, there is great demand to the Chinese medicine of effectively treating Qi deficiency blood stasis type hemoptysis caused by bronchiectasis in people.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, and this Chinese medicine can the TCM syndrome sign of obvious reduction of patient, achieves good clinical efficacy.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, be made up of the Chinese medicine of following weight portion:

Radix Ginseng 8-16 part, Radix Astragali 8-16 part, Rhizoma Dioscoreae 11-19 part, from the beginning blood 8-16 part, Radix et Rhizoma Smilacis Ripariae 5-13 part, Radix Rubiae 5-13 part, Radix Notoginseng 5-13 part, Folium rhoeinis 5-13 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-13 part, Folium Callicarpae Formosanae 5-13 part, long stalk Herba lysimachiae capillipedis 5-13 part, Rhizoma Chuanxiong 8-16 part, thick leaf tree 8-16 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, is made up of the Chinese medicine of following weight portion:

Radix Ginseng 10-14 part, Radix Astragali 10-14 part, Rhizoma Dioscoreae 13-15 part, from the beginning blood 10-14 part, Radix et Rhizoma Smilacis Ripariae 7-11 part, Radix Rubiae 7-11 part, Radix Notoginseng 7-11 part, Folium rhoeinis 7-11 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-11 part, Folium Callicarpae Formosanae 7-11 part, long stalk Herba lysimachiae capillipedis 7-11 part, Rhizoma Chuanxiong 10-14 part, thick leaf tree 10-14 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, is made up of the Chinese medicine of following weight portion:

Radix Ginseng 12 parts, the Radix Astragali 12 parts, Rhizoma Dioscoreae 15 parts, from the beginning blood 12 parts, Radix et Rhizoma Smilacis Ripariae 9 parts, 9 parts, Radix Rubiae, Radix Notoginseng 9 parts, Folium rhoeinis 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, Folium Callicarpae Formosanae 9 parts, long stalk Herba lysimachiae capillipedis 9 parts, Rhizoma Chuanxiong 12 parts, thick leaf set 12 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

Blood another name XUEJINGCAO, derives from Rubiaceae Herba Ophiorrhizae japonicae Ophiorrhiza umbricola W. W. Smith., with all herbal medicine from the beginning.Nature and flavor are micro-sweet, puckery, temperature.Function cures mainly promoting blood flow to regulate menstruation, benefiting qi and nourishing blood, granulation promoting, cough-relieving.

Radix et Rhizoma Smilacis Ripariae another name horse hair is stretched root, is crossed river Herba pteridii latiusculi, Lao Longxu, Buddha's warrior attendant bean rattan, careless Rhizoma Smilacis Chinensis, DASHENJINCAO, Herba Lycopodii serrati, Fin Cyprinus carpio, mountain Semen vignae sinensis.Source is the root and rhizome of liliaceous plant Radix et Rhizoma Smilacis Ripariae.Nature and flavor sweetness and bitterness, flat.Function inrigorating qi and promoting blood circulation, channels sootheing and network vessel quickening.Control deficiency of vital energy edema, bones and muscles pain, hemiplegia, dizziness headache, cough is spitted blood, bone tuberculosis, leucorrhea.

Radix et Rhizoma Smilacis Ripariae another name horse hair is stretched root, excessively river Herba pteridii latiusculi, Lao Longxu, Buddha's warrior attendant bean rattan, DASHENJINCAO, back beam bone, Herba Lycopodii serrati, Fin Cyprinus carpio, mountain Semen vignae sinensis, is shaken limit bamboo, Bai Xugong, soft leaf Rhizoma Smilacis Chinensis.For the root and rhizome of liliaceous plant Radix et Rhizoma Smilacis Ripariae Smilax riparia A. D C..Sweet; Bitter; Flat.Return liver, lung meridian.Function wind-damp dispelling; The meridian dredging; Expelling phlegm for arresting cough.Main air arthralgia chiefly caused by damp pathogen is demonstrate,proved; Impairment caused by overstrain lumbago; Traumatic injury; Cough and asthma

Folium rhoeinis calls red Folium rhoeinis, originates as the leaf of Commelianaceae plant purple Rohdea japonica Roth Rhoeo discolor (L'Her.) Hance.Sweet in the mouth; Cool; Light.Function heat-clearing and toxic substances removing; Removing stasis to stop bleeding.Main cough due to lung-heat; Spit blood; Epistaxis; Have blood in stool; Dysentery; Traumatic injury; Scrofula; Furuncle.

Long stalk Herba lysimachiae capillipedis another name long handle American lotus is the herb of Ofthe Primulaceae long stalk Lysimachia christinae Hance Lysimachia longipes Hemsl..Sweet in the mouth; Property is put down.Function relieves dizziness, high fever, infantile convulsions, epilepsy, etc. arresting convulsion; Astringing to arrest bleeding.Main infantile convulsion; Pulmonary tuberculosis is spat blood; Knife injury is hemorrhage.

Young, century-old blue or green, the Radix osteomelis schwerinais Sarcococca ruscifolia Stapf of thick leaf tree another name thousand, derives from open country, Buxaceae Sarcococca plant Yunnan fan flower Sarcococca hookeriana Baill., is used as medicine with Herb.Nature and flavor are bitter, puckery, cold.Function dissipating blood stasis stops blooding, promoting the circulation of QI to relieve pain, removing toxic substances and promoting tissue regeneration.For stomachache, bronchitis, hepatitis, ascariasis; Traumatic injury is controlled in external, and knife injury is hemorrhage, innominate toxic swelling.

Folium Callicarpae Formosanae another name Folium Callicarpae Formosanae, Folium Callicarpae Formosanae, derive from Verenaceae Callicarpa plant callicarpa pedunculata Callicarpa pedunculata R. Brown and Callicarpa dichotoma C. dichotoma (Lour.) K. Koch., be used as medicine with stem, leaf and root.Bitter in the mouth, puckery, property is put down.Function is stopped blooding, dissipating blood stasis, antiinflammatory.For epistaxis, spitting of blood, gastrointestinal hemorrhage, metrorrhagia, upper respiratory tract infection, tonsillitis, pneumonia, bronchitis; Traumatic hemorrhage is controlled in external, burn.

Other Chinese medicine related in prescriptions of Chinese medicine of the present invention all records in Chinese Pharmacopoeia 2010 editions.

Tracheaectasy spitting of blood belong to " lung abscess " or, " hemoptysis " category, ancient Chinese has early had understanding for this type of disease.The spitting of blood traditional Chinese medical science is also known as hemoptysis hemoptysis, spitting of blood, hemoptysis.The positive QI-insufficiency of ferritic is the internal condition of primary disease morbidity.Blood stasis due to qi deficiency is one of its different TCM syndrome types, and its basic pathogenesis is the damage that overstrain can cause the heart, spleen, kidney qi the moon.Or prolonged illness or calentura make healthy energy lose, deficient QI failing to control, blood oozing from the body openings or subcuta neous tissue arteries and veins is outer and cause hemorrhage; Prolonged illness people network, makes blood-vessel obstructive, hematogenous blockage, escape of blood from meridians and cause hemorrhage.Should adopt QI invigorating circulation of qi promoting, promoting blood circulation and hemostasis method is treated

Chinese medicine of the present invention, prescription mechanism is as follows:

Monarch drug: Radix Ginseng, the Radix Astragali, Rhizoma Dioscoreae merit are with air making-up and spleen enlivening lung benefiting.

Ministerial drug: blood, Radix et Rhizoma Smilacis Ripariae merit are with QI invigorating of invigorating blood circulation from the beginning.

Adjuvant drug: Radix Rubiae, Radix Notoginseng, Folium rhoeinis merit are with removing stasis to stop bleeding; Pseudobulbus Bletillae (Rhizoma Bletillae), Folium Callicarpae Formosanae, long stalk Herba lysimachiae capillipedis merit are with astringing to arrest bleeding.Rhizoma Chuanxiong, thick leaf tree merit is with blood-activating and qi-promoting.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share plays QI invigorating circulation of qi promoting, the effect of promoting blood circulation and hemostasis altogether, the etiology and pathogenesis of the bronchiectasis syndrome of blood stasis due to qi deficiency that links closely, can the clinical symptoms of obvious reduction of patient, achieves good clinical efficacy, is worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, each crude drug weight proportion is as follows:

Radix Ginseng 12g, Radix Astragali 12g, Rhizoma Dioscoreae 15g, from the beginning blood 12g, Radix et Rhizoma Smilacis Ripariae 9g, Radix Rubiae 9g, Radix Notoginseng 9g, Folium rhoeinis 9g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9g, Folium Callicarpae Formosanae 9g, long stalk Herba lysimachiae capillipedis 9g, Rhizoma Chuanxiong 12g, thick leaf tree 12g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, each crude drug weight proportion is as follows:

Radix Ginseng 10g, Radix Astragali 14g, Rhizoma Dioscoreae 13g, from the beginning blood 14g, Radix et Rhizoma Smilacis Ripariae 7g, Radix Rubiae 11g, Radix Notoginseng 7g, Folium rhoeinis 11g, Pseudobulbus Bletillae (Rhizoma Bletillae) 7g, Folium Callicarpae Formosanae 11g, long stalk Herba lysimachiae capillipedis 7g, Rhizoma Chuanxiong 14g, thick leaf tree 10g, Radix Glycyrrhizae 7g.

Embodiment 3

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, each crude drug weight proportion is as follows:

Radix Ginseng 14g, Radix Astragali 10g, Rhizoma Dioscoreae 15g, from the beginning blood 10g, Radix et Rhizoma Smilacis Ripariae 11g, Radix Rubiae 7g, Radix Notoginseng 11g, Folium rhoeinis 7g, Pseudobulbus Bletillae (Rhizoma Bletillae) 11g, Folium Callicarpae Formosanae 7g, long stalk Herba lysimachiae capillipedis 11g, Rhizoma Chuanxiong 10g, thick leaf tree 14g, Radix Glycyrrhizae 5g.

Embodiment 4

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, each crude drug weight proportion is as follows:

Radix Ginseng 8g, Radix Astragali 16g, Rhizoma Dioscoreae 11g, from the beginning blood 16g, Radix et Rhizoma Smilacis Ripariae 5g, Radix Rubiae 13g, Radix Notoginseng 5g, Folium rhoeinis 13g, Pseudobulbus Bletillae (Rhizoma Bletillae) 5g, Folium Callicarpae Formosanae 13g, long stalk Herba lysimachiae capillipedis 5g, Rhizoma Chuanxiong 16g, thick leaf tree 8g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, each crude drug weight proportion is as follows:

Radix Ginseng 16g, Radix Astragali 8g, Rhizoma Dioscoreae 19g, from the beginning blood 8g, Radix et Rhizoma Smilacis Ripariae 13g, Radix Rubiae 5g, Radix Notoginseng 13g, Folium rhoeinis 5g, Pseudobulbus Bletillae (Rhizoma Bletillae) 13g, Folium Callicarpae Formosanae 5g, long stalk Herba lysimachiae capillipedis 13g, Rhizoma Chuanxiong 8g, thick leaf tree 16g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose bronchiectasis Patients with Qi-deficiency Causing Blood 160 example.

1.2 diagnostic criterias:

Western medicine diagnose standard:

(1) hemoptysis expectorant, can be sputum mixed with blood, or cerise is mixed with foam, and pH is in alkalescence.Check that oral cavity, nasopharynx part are without hemorrhage.

(2) most of patients has and repeatedly coughs up (coughing) blood history.

(3) chest x-ray takes the photograph sheet, can change without specificity.Cellular or curly hair sample shade as seen when pathological changes is obvious.

(4) Bronchography or bronchoscopy is made if desired, the expansion of visible column, cryptomere or mixed type.

Differential diagnosis in tcm diagnostic criteria: the diagnostic criteria having stipulated spitting of blood blood stasis due to qi deficiency with reference to " new Chinese medicine treatment hemoptysis guideline of clinical investigations ": repeatedly spit blood, color is scarlet, and dry cough expectorant is few, dry mouth and throat.Red tongue with yellow fur, few Tianjin, thready and rapid pulse.

1.3 inclusive criterias:

L () meets Western medicine diagnose standard and above Standards of Chinese Medical Syndrome Differentiation person.

(2) age being in hospital or outpatient in 18 ~ 79 one full year of life.

(3) can coordinate and check and the person that looks into and be ready to take Chinese medicine can be covered by partner treatment.

1.4 exclusion standards:

(1) under-18s or more than 79 one full year of life.

(2) be unwilling to take treatment by Chinese herbs person.

(3) allergy sufferers is had to this medicine.

(4) gestation or women breast-feeding their children.

(5) urgent massive hemorrhage, must operative treatment or be associated with serious cardiovascular, liver, kidney and hematopoietic disease, cyclothymic and person lost to follow-up.

(6) do not take medicine according to the rules, mismatch treatment and cover and look into, cannot judge that curative effect or data are complete, affect the treatment and safety judgement person.

1.5 Therapeutic Method

Give Chinese medicine of the present invention, prescription: Radix Ginseng 12g, Radix Astragali 12g, Rhizoma Dioscoreae 15g, from the beginning blood 12g, Radix et Rhizoma Smilacis Ripariae 9g, Radix Rubiae 9g, Radix Notoginseng 9g, Folium rhoeinis 9g, Pseudobulbus Bletillae (Rhizoma Bletillae) 9g, Folium Callicarpae Formosanae 9g, long stalk Herba lysimachiae capillipedis 9g, Rhizoma Chuanxiong 12g, thick leaf tree 12g, Radix Glycyrrhizae 6g.Be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.

1.6 main clinic symptoms grade scales:

Spitting of blood:

I level: a small amount of hemoptysis, internal hemorrhage amount was less than 100ml in one day, or within a hemoptysis amount 50ml, was designated as 1 point.

II grade: middle amount hemoptysis, within one day, internal hemorrhage amount is at 100 ~ 500ml, or within a hemoptysis amount 50 ~ 100ml, is designated as 2 points.

III grade: a large amount of hemoptysis, within one day, internal hemorrhage amount is more than 500ml, or more than a hemoptysis amount 100ml, more than 100 beats/min, pulse, and hemoglobin, lower than 100g/L, is designated as 3 points.

Heating:

Nothing heating is 0 point

37 ~ 37.9 DEG C is 1 point

38 ~ 38.9 DEG C is 2 points

More than 39 DEG C is 3 points

Cough:

I level: daytime is interrupted cough, and not affecting orthobiosis is 1 point

II grade: full-time interruption cough, affecting orthobiosis is a little 2 points

III grade: cough is frequent round the clock, affect work and sleep is 3 points

Fatigue and weakness:

I level: tired a little, can adhere to that physical exertion is 1 point

II grade: more very, maintain orthobiosis is reluctantly 2 points to asthenia

III grade: myasthenia of limbs, can not adhere to that daily life is 3 points

Spiritlessness and sparing of words:

I level: lassitude, does not like polylogia, pays no attention to that not answer be 1 point

II grade: metal fatigue, drowsy emblem speech, asks that answer is 2 points more more

III grade: extremely tired, even language is 3 points.

1.7 efficacy evaluations:

With reference to " new Chinese medicine treatment hemoptysis guideline of clinical investigations "

1. fully recover: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.

Computing formula: nimodipine method: integration x100% before (before treatment the rear integration of integration-treatment)/treatment.

1.8 statistical method

Using statistics software carries out analytic statistics analysis.Enumeration data adopts X2 inspection, and measurement data adopts t inspection, with P<0.05, ranked data Bian rank test, represents that difference has statistical significance.

2. result

Main clinic symptoms integral contrast before and after 2.1 treatments

After treatment, main clinic symptoms integration obviously reduces before all comparatively treating, and difference has statistical significance (P<0.05), in table 1.

Front and back disease integral contrast treated by table 1

Time	Spitting of blood	Heating	Cough	Fatigue and weakness	Spiritlessness and sparing of words
						Before treatment	2.82±0.15	2.73±0.31	2.65±0.32	2.54±0.46	2.72±0.33
After treatment	0.62±0.14	0.56±0.08	0.60±0.12	0.47±0.09	0.71±0.14
						T value	4.235	4.866	4.345	4.653	3.654
P value	0.010	0.007	0.011	0.009	0.015

2.2 clinical efficacy

160 routine patients, cure 108 examples, effective 40 examples, effective 10 examples, invalid 2 examples, cure rate 67.5%, total obvious effective rate 92.5%, total effective rate 98.75%.

Claims (3)

1. treat a Chinese medicine for Qi deficiency blood stasis type hemoptysis caused by bronchiectasis, be made up of the Chinese medicine of following weight portion:

Radix Ginseng 8-16 part, Radix Astragali 8-16 part, Rhizoma Dioscoreae 11-19 part, from the beginning blood 8-16 part, Radix et Rhizoma Smilacis Ripariae 5-13 part, Radix Rubiae 5-13 part, Radix Notoginseng 5-13 part, Folium rhoeinis 5-13 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 5-13 part, Folium Callicarpae Formosanae 5-13 part, long stalk Herba lysimachiae capillipedis 5-13 part, Rhizoma Chuanxiong 8-16 part, thick leaf tree 8-16 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:

Radix Ginseng 10-14 part, Radix Astragali 10-14 part, Rhizoma Dioscoreae 13-15 part, from the beginning blood 10-14 part, Radix et Rhizoma Smilacis Ripariae 7-11 part, Radix Rubiae 7-11 part, Radix Notoginseng 7-11 part, Folium rhoeinis 7-11 part, Pseudobulbus Bletillae (Rhizoma Bletillae) 7-11 part, Folium Callicarpae Formosanae 7-11 part, long stalk Herba lysimachiae capillipedis 7-11 part, Rhizoma Chuanxiong 10-14 part, thick leaf tree 10-14 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of Qi deficiency blood stasis type hemoptysis caused by bronchiectasis according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:

Radix Ginseng 12 parts, the Radix Astragali 12 parts, Rhizoma Dioscoreae 15 parts, from the beginning blood 12 parts, Radix et Rhizoma Smilacis Ripariae 9 parts, 9 parts, Radix Rubiae, Radix Notoginseng 9 parts, Folium rhoeinis 9 parts, Pseudobulbus Bletillae (Rhizoma Bletillae) 9 parts, Folium Callicarpae Formosanae 9 parts, long stalk Herba lysimachiae capillipedis 9 parts, Rhizoma Chuanxiong 12 parts, thick leaf set 12 parts, 6 parts, Radix Glycyrrhizae.