CN105012647A - Traditional Chinese medicine composition for treating cold-dampness blocking collaterals type diabetic limb early-stage arteriosclerosis obliterans - Google Patents

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a traditional Chinese medicine composition for treating cold-dampness blocking collaterals type diabetic limb early-stage arteriosclerosis obliterans. The traditional Chinese medicine composition comprises the following Chinese herbs in parts by weight: 4-8 parts of star anise, 4-8 parts of arisaema faregesii Buchet, 4-8 parts of lily of the valley, 4-8 parts of cassia twig, 11-19 parts of beechey fig leaf, 5-13 parts of aralia melanocarpa, 4-8 parts of fomes officinalis ames, 2-4 parts of fatsia japonica, 5-13 parts of herba alyxiae sinensis, 4-8 parts of phlegmariurus petiolatus herb, 5-13 parts of aralia undulata, 5-13 parts of hypericum monanthemum Hook. f. et Thorns. ex Dyer, 4-8 parts of whitewood, 6-14 parts of noble bottle tree husk, 4-8 parts of oxhide gelatin, 6-14 parts of rugosa paraphlomis and 4-8 parts of liquorice. All of the Chinese herbs are combined to realize the efficacies of warming yang and invigorating qi, reducing phlegm and eliminating dampness, and activating blood circulation to dredge collaterals, so that the traditional Chinese medicine composition can resist platelet aggregation, reduce blood viscosity, dilate blood vessels, increase blood flow velocity, and improve clinical symptoms and lower limb blood circulation.

Description

A kind of Chinese medicine composition for the treatment of the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine composition for the treatment of the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs.

Background technology

Diabetes limb artery sclerosis obliterans (DLASO) is one of great vessels complication in diabetic patients, and main pathology changes into atherosclerosis, tube wall thickening, and luminal stenosis and thrombosis, finally cause arterial occlusion, local organization ischemia.Treatment should adopt comprehensive therapy measure, actively controls blood glucose, blood pressure, adjustment disorders of lipid metabolism; Lower limb blood circulation is promoted by falling fibre, anticoagulant, thrombolytic, expansion blood vessel etc.; Treat other complication, be the key of diabetes limb artery sclerosis obliterans treatment simultaneously.

Symptomatic treatment is taked in the treatment in west more, but curative effect is often not good, and its reason is doctor trained in Western medicine only for blocking in pathological process the pathology link only having one or more.Chinese Traditional Medicine treatment not only long and rich experience, its base oneself upon entirety, the dialectical unique advantage treated especially modern medicine be difficult to the part that matches in excellence or beauty.Therefore, the Chinese medicine finding the early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs is needed.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, provides a kind of Chinese medicine composition for the treatment of the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 4-8 part, Radix Mirabilis himalaicae 4-8 part, Eriocheir sinensis seven 4-8 part, red Radix Aconiti 6-14 part, Lignum seu Radix Acronychiae 4-8 part, Herba Alyxiae Sinensis 5-13 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 4-8 part, Radix Araliae undulatae 5-13 part, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 5-13 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 6-14 part, gelatinum oxhide 4-8 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 6-14 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine composition of the above-mentioned early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 5-7 part, Radix Mirabilis himalaicae 5-7 part, Eriocheir sinensis seven 5-7 part, red Radix Aconiti 8-12 part, Lignum seu Radix Acronychiae 5-7 part, Herba Alyxiae Sinensis 7-11 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 5-7 part, Radix Araliae undulatae 7-11 part, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 7-11 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 8-12 part, gelatinum oxhide 5-7 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 8-12 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine composition of the above-mentioned early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs, is made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 6 parts, Radix Mirabilis himalaicae 6 parts, Eriocheir sinensis 76 parts, red Radix Aconiti 10 parts, Lignum seu Radix Acronychiae 6 parts, Herba Alyxiae Sinensis 9 parts, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 6 parts, Radix Araliae undulatae 9 parts, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 9 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 10 parts, gelatinum oxhide 6 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 10 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of g, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

In Chinese medicine composition of the present invention,

Fructus Foeniculi on Fructus Anisi Stellati another name oceangoing ship, Fructus Anisi Stellati, oceangoing ship Fructus Foeniculi, Fructus Foeniculi Octagonal bead, Radix Cacaliae Ainsliaeflorae, anistree Fructus Anisi Stellati, anistree, crude oil fennel, anistree greatly.Source is the fruit of Magnoliacea plant Fructus Anisi Stellati.Acrid-sweet flavor, warm in nature.Function warming YANG, cold expelling, regulates the flow of vital energy.Control invasion by pathogenic cold vomiting, colic of cold type is suffered from abdominal pain, lumbago due to renal deficiency, dry, beriberi caused by pathogenic damp.

Radix Mirabilis himalaicae calls eight Zhu, is the root of Nyctaginaceae plant Radix Mirabilis himalaicae Mirabilishimalaica(Edgew.Heimerl. [OxybaphushimalaicusEdgew.].Sweet in the mouth; Micro-pungent; Slightly warm in nature.Return spleen channel; Kidney channel.Function warming YANG to promote diuresis.Main yang deficiency edema; Sexual impotence; Stranguria.

Eriocheir sinensis seven calls few fringe Radix et rhizoma smilacinae japonicae, few Honoka, ferrum cripple, derives from Liliaceae Smilacina plant tube flower Radix et rhizoma smilacinae japonicae Smilacinahenryi(Baker) WangetTang, is used as medicine with root stock and root.Sweet in the mouth, warm in nature.Function temperature male wind-supplying kidney, expelling wind and removing dampness, blood circulation promoting and blood stasis dispelling.For sexual impotence, traumatic injury, Fengshi Guanjie pain.

Red Radix Aconiti another name Dobinea delavayi, xanthate root are feverfew Radix Cacaliae davidii Cacaliadauidii (Franch.) Hand.-Mazz. [SeneciodauidiiFranch.; Sinacaliadauidii (Franch.) Hand.-Mazz.] tuber.Acrid in the mouth; Warm in nature.Function expelling wind and removing dampness; Cold expelling dredging collateral.Main air damp lumbago; Rheumatism completes paralysis; Hemiplegia; Headache; Head sore is bald in vain; Traumatic injury.

Lignum seu Radix Acronychiae the another name brightly yellowish company of buckwheat, successively crow, Herba hedyotis costatae, middle ginseng, Herba sopubiae Trifidae, Cortex torricelliae tiliifoliae, Cymbidium ensifolium (L.) Sw. of ancient India, little Cymbidium ensifolium (L.) Sw., reddle ginseng, the cool larynx grass of microcephaly, headdress flower Auricled Hedyotis Herb, poly-flower rattan.For the Herb of dicotyledon medicine Maguireothamnus speciosus microcephaly cool larynx tea HedyotiscapitellataWall.ExG.Don [Oldenlandiacapitellata (Wall.exG.Don) O.Kuntae].Lightly seasoned; Warm in nature.Return liver; Spleen; Kidney channel.Function cold expelling dredging collateral; Nourish blood; Preventing the attack (or recurrence) of malaria.Main malaria; Affection of exogenous wind-cold; Menoxenia; Puerperal galactostasis; Dry cough; Dermatitis rhus; Fracture trauma.

Herba Alyxiae Sinensis another name beads rattan, Semen Benincasae rattan, Semen Benincasae English, feather tree, Clausena excavata Burm.f., Herba Alyxiae Sinensis, excessively bone limit, Herba Polygalae Japonicae, Radix Buddlejae Butterflybush.Derive from herb and the root of apocynaceae plant chain pearl rattan.Bitter in the mouth is pungent, warm in nature.Function expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral.Treating rheumatic arthralgia, diarrhea due to hypofunction of the spleen, beriberi, general edema, married woman's amenorrhea, traumatic injury.

Phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching is that Huperziaceae plant has handle horse hair shirt Phlegmariurushamiltonii(Spreng.) herb of LoveetLovevar.petiolatus (Clarke) Ching.Function promoting blood circulation to remove obstruction in the collateral; Inducing diuresis and reducing edema.Main traumatic injury; Lumbago; Edema.

Radix Araliae undulatae another name HONGCI brain bag, sky, top thorn, Aralia mandshurica, Sedum aizoon L., purplish red umbrella.For the root of Araliaceae Radix Araliae undulatae: AraliaundulataHand.-Mazz.Bitter in the mouth; Pungent; Cool in nature.Function blood circulation promoting and blood stasis dispelling; Inducing menstruation to relieve menalgia; Expelling wind and removing dampness.Main traumatic injury; Fracture; Mass in the abdomen; Amenorrhea; Dysmenorrhea; Impairment caused by overstrain pain; Rheumatalgia.

Single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) another name Semen arachidis hypogaeae grass, Premna microphylla Turez, two muscle grass, Herba Artemisiae Anomalae.For the herb of Garcinia maingayii long lobe Radix Hyperici Monogyni (Herba Hyperici Monogyni) HypericummonanthemumHook.f.etThoms.exDver.Micro-hardship; Property is put down.Function blood circulation promoting and blood stasis dispelling.Main menoxenia; Dysmenorrhea.

Rhizoma Atractylodis macrocephalae calls Folium seu Radix Clausenae dentatae, Ovum Gallus domesticus Flavus, little Citrus chachiensis Hort., Radix araliae armatae, puts loose, wild Fructus Capsici on the skin.For rutaceae bassoon Micromelumfalcatum(Lour.) root of Tanaka [AulasiafalcatumLour.] or leaf.Acrid in the mouth; Bitter; Warm in nature.Return liver; Kidney channel.Function blood-activating and qi-promoting; Eliminating stasis to stop pain.The main thoracic obstruction; Treating swelling and pain by traumatic injury; Fracture; Sprain; Rheumatic arthralgia; Wait pain; Venom.

Pericarpium Sterculiae nobilis another name Semen Sterculiae Nobilis pod, sterculia nobilis's shell.For the shell of Sterculiaceae plant sterculia nobilis SterculianobilisSmith.Sweet in the mouth; Property is put down.Return small intestine meridian.Function blood-activating and qi-promoting.Main dysentery; Inguinal hernia; Hemorrhoid; Otitis media.

Gelatinum oxhide another name glue, animal glue, extra large rhinoceros glue, Guangton glue, gelatin.For the glue of the Pi Suoao of bovid cattle.Sweet, flat, nontoxic.Enter lung, large intestine channel.Function is nourshing Yin and drynsessmoistening prescription, hemostasia and detumescence.Control asthenia consumptive lung disease, cough spitting of blood, tells nosebleed, metrorrhagia.

Native nine uncompleted buildings of Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu another name, large pellet in a shotgun cartridge dish, tall bottle with spout flower is root or the herb of false Herba phlomidis Paraphlomisjauanica (Bl.) Prainvar.coronata (Vaniot) C.Y.WuetH.w.Li [P.rugosa (Benth.) Prainvar.coronata (Vaniot) C.Y.Wu] of labiate lobule.Sweet in the mouth; Property is put down.Function is nourshing Yin and drynsessmoistening prescription; Cough-relieving; Regulating menstruation.Main deficiency of YIN chronic cough; Sputum mixed with blood; Menoxenia.

Radix Glycyrrhizae is sweet, flat.GUIXIN, lung, spleen, stomach warp.Function invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

Diabetes limb artery sclerosis obliterans is attributed to " necrosis " category ".Cold-dampness is the main pathogenesis of diabetic arterial occlusion of lower extremities (in early days).Think that the body in old age is many because of deficiency of spleen-YANG and kidneyYANG, experience the heresy of cold-damp, inside and outside be harmonious, then suffering limb happiness is warm is afraid of cold, palor; Cold-dampness, yang-energy can not reach in four ends outward, then torpor and swelling, and that touches sends out cool; Internal retention of cold wetness, QI and blood is not all right, and when walking, the stasis of blood is stagnant does not more reach for QI and blood more, therefore the pain increased; Cold-dampness, then fall YANG pulse and beat and weaken; Light red tongue, tongue in vain greasy, deep-thready pulse are resembling of the cold Sheng of yang deficiency.The sick position of diabetes limb artery sclerosis obliterans is at limbs blood vessels, and pathogenesis key is deficiency of spleen-YANG and kidneyYANG, Cold-dampness, causes acral mistake to be supported.Therefore treatment should with warming YANG to expel cold, promoting blood circulation to remove obstruction in the collateral is main.

The prescription mechanism of the Chinese medicine composition of the early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs of the present invention is as follows:

Monarch drug: Fructus Anisi Stellati, Radix Mirabilis himalaicae, Eriocheir sinensis seven merit are with warming YANG to expel cold.

Ministerial drug: red Radix Aconiti, Lignum seu Radix Acronychiae merit are with cold expelling dredging collateral.

Adjuvant drug: Herba Alyxiae Sinensis, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching merit are with promoting blood circulation to remove obstruction in the collateral, and Radix Araliae undulatae, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) merit are with blood circulation promoting and blood stasis dispelling.Rhizoma Atractylodis macrocephalae, Pericarpium Sterculiae nobilis merit are with blood-activating and qi-promoting.Gelatinum oxhide, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu merit with nourshing Yin and drynsessmoistening prescription, implied meaning interdependence between yin and yang alternate, and anti-predominant yang impairing yin.

Make medicine: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, mainly share the effect of playing warming YANG and invigorating QI, dispelling phlegm and eliminating dampness, promoting blood circulation to remove obstruction in the collateral altogether.Link closely DLASO(cold dampness accumulation pattern) etiology and pathogenesis; Can antiplatelet aggregation, improve blood viscosity, expand blood vessel, speed blood flow rate, improve clinical symptoms and lower limb blood circulation, there is good efficacy early stage (Cold-dampness) aspect for the treatment of diabetes limb artery sclerosis obliterans.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 6g, Radix Mirabilis himalaicae 6g, Eriocheir sinensis seven 6g, red Radix Aconiti 10g, Lignum seu Radix Acronychiae 6g, Herba Alyxiae Sinensis 9g, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 6g, Radix Araliae undulatae 9g, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 9g, Rhizoma Atractylodis macrocephalae 6g, Pericarpium Sterculiae nobilis 10g, gelatinum oxhide 6g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 10g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 5g, Radix Mirabilis himalaicae 5g, Eriocheir sinensis seven 5g, red Radix Aconiti 8g, Lignum seu Radix Acronychiae 5g, Herba Alyxiae Sinensis 7g, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 5g, Radix Araliae undulatae 7g, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 7g, Rhizoma Atractylodis macrocephalae 5g, Pericarpium Sterculiae nobilis 8g, gelatinum oxhide 5g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 8g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 7g, Radix Mirabilis himalaicae 7g, Eriocheir sinensis seven 7g, red Radix Aconiti 12g, Lignum seu Radix Acronychiae 7g, Herba Alyxiae Sinensis 11g, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 7g, Radix Araliae undulatae 11g, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 11g, Rhizoma Atractylodis macrocephalae 7g, Pericarpium Sterculiae nobilis 12g, gelatinum oxhide 7g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 12g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 8g, Radix Mirabilis himalaicae 8g, Eriocheir sinensis seven 8g, red Radix Aconiti 14g, Lignum seu Radix Acronychiae 8g, Herba Alyxiae Sinensis 13g, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 8g, Radix Araliae undulatae 13g, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 13g, Rhizoma Atractylodis macrocephalae 8g, Pericarpium Sterculiae nobilis 14g, gelatinum oxhide 8g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 14g, Radix Glycyrrhizae 8g.

Embodiment 5

Treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, each crude drug weight proportion is as follows:

Fructus Anisi Stellati 4g, Radix Mirabilis himalaicae 4g, Eriocheir sinensis seven 4g, red Radix Aconiti 6g, Lignum seu Radix Acronychiae 4g, Herba Alyxiae Sinensis 5g, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 4g, Radix Araliae undulatae 5g, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 5g, Rhizoma Atractylodis macrocephalae 4g, Pericarpium Sterculiae nobilis 6g, gelatinum oxhide 4g, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 6g, Radix Glycyrrhizae 4g.

Carried out clinical pharrnacokinetics test to Chinese medicine composition of the present invention, Details as Follows:

1. data and method

1.1 object of study

Select diabetes limb artery sclerosis obliterans (cold dampness accumulation pattern) patient 150 example meeting inclusive criteria.

1.2 diagnostic criteria

(1) Western medicine diagnose

With reference to the diabetes diagnostic criterion that the WHO Committee of Experts in 1999 and ADA advise.2004 Chinese combination of Chinese and Western medicine peripheral vascular disease Professional Committees work out " diabetic arterial occlusion of lower extremities " diagnostic criteria and staging scale.As follows:

(1) age of onset: many more than 40 years old.

(2) diabetes medical history is had.

(3) have chronic limb artery ischemia to show: numb limbs and tense tendons, be afraid of cold (or To Be Protected from Heat), intermittent row of crossing mountains, blood stasis, nutrition change, limbs feel to go down or skin rubefaction scorching hot, notably generation ulcer or gangrene;

(4) normal extremity morbidity, attaches most importance to lower limb;

(5) various Inspection Certificate has limb artery stenosis occlusion to sexually revise, and artery of lower extremity becomes the most common with telemechanical disorders of meridian.

(6) normal with hypertension, coronary heart disease, hyperlipemia, renal artery angiopathy, cerebrovascular and Fundus oculi artery vascular lesion etc.Get rid of other ischemic diseasess such as thromboangiitis obliterans, Takayasu arteritis, Raynaud disease, Cold water stress angiopathy.

Auxiliary examination:

(1) limb artery not damaged checks: color Doppler, CT, DSA (Digital Subtraction), Vascular Ultrasonography, the inspection of blood vessel photocapacitance hematocele flow graph confirm there is the narrow or inaccessible person of limb artery.(2) the following main drive disorders of meridian of angiography becomes master, tremulous pulse accounts for more than 80% with arterial disease far away, and angiopathy disfigurement state is atherosclerotic occlusive disease quite seemingly, due to limb artery sclerosis widely, diabetes, therefore collateral artery blood vessel is less, blood vessel can occur tortuous, narrow, inaccessible.(3) blood pressure determination of Doppler's ankle obviously diminishes with the ratio of wrist blood pressure mensuration.(4) x-ray plain film checks: aortic arch, ventral aorta or artery of lower extremity have calcification shadow.

(2) differential diagnosis in tcm diagnostic criteria

With reference to diabetic arterial occlusion of lower extremities cold dampness accumulation pattern dependent diagnostic standard in " new Chinese medicine guideline of clinical investigations ": limbs happiness is warm is afraid of cold, numb, swelling and pain, walk that the pain increased, alleviation of pain of slightly having a rest, palor more, that touches sends out cool, and FU YANG pulse the pulse of anterior tibial artery is beaten and weakened; Light red tongue, tongue is greasy in vain, deep-thready pulse.

1.3 clinical stages standard

0 phase: (symptom concealment phase) main weak based on limbs, fatiguability, fearness are cool, acid is swollen, numbness.

First phase: (ischemia phase) has chronic ischemia of extremities to show, with intermittence postscript behavior master, limbs are sent out cool, and numbness, distending pain, cold tolerance go down.

Second phase: the performance of (malnutrition phase) limb ischemia increases the weight of, pachylosis, fine hair come off, toenail plumpness, fat pad atrophy, intermittent postscript row, rest pain etc.

Three phases: (downright bad phase) has chronic ischemia of extremities performance, as except intermittent cross mountains row, rest pain, there is extremity ulcer and gangrene.

1.4 inclusive criteria

(1) meet diabetes diagnostic criterion and diabetic arterial occlusion of lower extremities diagnostic criteria, and clinical stages is 0 phase and first phase person.

(2) meet the early diagnosis standard from intending diabetes limb arteries sclerosis obliterans: clinical manifestation be limbs weak, be afraid of cool, acid is swollen, numb, intermittent postscript is gone, artery of lower extremity color doppler ultrasonography shows two artery of lower extremity intimal thickening, sclerosis or speckle, and blood flow rate drops to the positive.

(3) the dialectical standard of cold dampness accumulation pattern is met.

(4) patient willingness's partner treatment, the age is 40-80 year.

1.5 exclusion standard

(1) patient of inclusive criteria is not met.

(2) Diabetic Acute complication is as the patient of ketoacidosis, hyperosmolar coma, lactic acidosis.

(3) other ischemic disease of limb such as thromboangiitis obliterans, Takayasu arteritis, raynaud disease, Cold water stress angiopathy.

(4) abnormal, the hematuria of the serious hepatic and renal function just conventional safety indexes influence research result person such as abnormal.

(5) other serious disease is merged: as the patient of malignant tumor, acute cerebrovascular disease, acute myocardial infarction, heart failure, severe psychiatric problem and disturbance of consciousness.

(6) previously severe drug allergies or allergic constitution person is had.

(7) gestation or nursing women.

1.6 Therapeutic Method

Give the Chinese medicine of the embodiment of the present invention 1, be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.

1.7 observation index

(1) clinical symptoms: with reference to the syndrome integral standard of nineteen ninety All-China Association of Traditional Chinese Medicine's vascular meeting Professional Committee revision atherosclerotic occlusive disease of Chen Shuchang chief editor, observation that the clinical symptoms before patient treatment and after treatment is scored respectively.Main detection: limbs cold type of pain, limbs are afraid of cold, numb limbs and tense tendons and intermittent claudication, are designated as 0,2,4,6 point respectively according to symptom weight.

(2) curative effect index:

Fasting glucose: adopt Roche happy Kang Quan-2 blood glucose meter to measure fasting glucose, respectively measure once before and after treatment.

Glycolated hemoglobin: the special analyser of diabetes (DCA2000+) adopting Bayer A.G to produce and test kit, respectively detects once before and after treatment.

Blood fat: blood fat adopts automatic clinical chemistry analyzer to measure, and respectively detects once before and after treatment.

Hemorheology: the N-6-LBY adopting the raw group of Beijing Puli to develop automatically cleans rotary viscosimeter and measures, before and after treatment, each detection once.

Ankle brachial index (ABI) value: adopt my department of endocrinology Britain of institute Hunter to carry out diabetic foot diagnosis case (probe model VPS/DFK01340, frequency probe 8MHz) survey bilateral forearm systolic pressure, and get high level and make brachial artery systolic pressure, then after detecting homonymy shin respectively, dorsal artery of foot systolic pressure gets high value as ankle systolic pressure.ABI value when putting down sleeping by special messenger's operational measure patient tranquillization.ABI value is ankle systolic pressure/brachial artery systolic pressure.Before and after treatment, each detection once.

Ultrasonic doppler blood flow checks: adopt my institute β-Ultrasound Room U.S. Vivid-7 arterial color doppler ultrasound (frequency probe 5-10MHZ), by special messenger's time-and-motion study tremulous pulse caliber, blood flow rate, pulsatility index, drag index and inner membrance situation, before and after treatment, each detection once.

1.8 curative effect judging standard

The criterion of therapeutical effect formulated with reference to nineteen ninety All-China Association of Traditional Chinese Medicine's vascular meeting Professional Committee and efficacy evaluation.

Clinical symptoms and sign evaluate curative effect to treat rear and before treating mark ratio size, and sum of scoring after namely treating is compared with sum of scoring before treating: clinical recovery: <0.3; Effective: 0.3-0.6 (not containing 0.6); Effective: 0.6-0.9 (not containing 0.9); Invalid: 0.9-1 (containing 1); Worsen: >l.

1.9 statistical method

Measurement data represents with mean plus-minus standard deviation, compares employing paired t-test before and after treatment; Above data application SPSS15.0 statistical software processes, and represents that difference has statistical significance with P<0.05.

2. result

Before and after 2.1 treatments, blood glucose situation compares

After treatment, fasting glucose and glycolated hemoglobin obviously reduce before all comparatively treating, and difference has statistical significance (P<0.05), in table 1.

Table 1 is treated front and back blood glucose and is compared

Time	Fasting glucose	Glycolated hemoglobin
			Before treatment	8.57±1.54	11.98±2.65
After treatment	6.12±0.46	7.17±1.07
			T value	3.663	3.736
P value	0.013	0.011

Clinical symptoms integral contrast before and after 2.2 treatments

After treatment, every clinical symptoms integration obviously reduces before all comparatively treating, and difference has statistical significance (P<0.05), in table 2.

Front and back clinical symptoms integral contrast treated by table 2

Time	Limbs cold type of pain	Limbs are afraid of cold	Numb limbs and tense tendons	Intermittent claudication
					Before treatment	5.65±0.75	5.74±0.65	4.98±0.76	4.42±0.72
After treatment	1.07±0.42	1.06±0.53	1.23±1.02	1.18±0.31
					T value	4.984	3.976	3.673	4.265
P value	0.008	0.013	0.015	0.011

Before and after 2.3 treatments, blood fat situation compares

After treatment, blood lipids index is obviously improved before all comparatively treating, and difference has statistical significance (P<0.05), in table 3.

Table 3 is treated front and back blood fat situation and is compared

Time	Cholesterol	Triglyceride	High density lipoprotein	Low density lipoprotein, LDL
					Before treatment	5.48±1.02	3.23±0.45	1.05±0.42	3.98±0.75
After treatment	3.03±0.72	1.01±0.64	3.32±1.13	1.24±0.41
					T value	3.765	3.452	3.655	3.445
P value	0.013	0.021	0.019	0.022

Before and after 2.4 treatments, lectin from hemolymph situation compares

After treatment, lectin from hemolymph index is obviously improved before all comparatively treating, and difference has statistical significance (P<0.05), in table 4.

Table 4 is treated front and back lectin from hemolymph situation and is compared

Time	Whole blood viscosity is low cuts	Cut in whole blood viscosity	Whole blood viscosity is high cuts	Platelet aggregation rate	Fibrinogen
						Before treatment	10.54±1.55	7.78±0.91	5.48±0.54	69.37±12.58	4.34±0.42
After treatment	7.22±0.57	5.02±0.63	3.31±0.42	31.67±6.52	2.02±0.51
						T value	4.287	4.165	3.967	5.643	4.655
P value	0.005	0.007	0.017	0.002	0.004

Before and after 2.5 treatments, ABI situation compares

After treatment, ABI obviously improves before all comparatively treating, and difference has statistical significance (P<0.05), in table 5.

Table 5 is treated front and back ABI situation and is compared

Arterial doppler color ultrasound blood circumstance change before and after 2.6 treatments

Treatment artery internal diameter (D), blood flow rate (V), pulsatility index (PI), drag index (RI) obviously improve before all comparatively treating, and difference has statistical significance (P<0.05), in table 6,7.

Artery internal diameter (D) treated by table 6 and blood flow rate (V) compares

Table 7 treats front and back pulsatility index (PI) and drag index (RI)

2.7 clinical efficacy

125 examples are cured, effective 12 examples, effective 12 examples, invalid 1 example, cure rate 83.3%, total obvious effective rate 91.3%, total effective rate 99.3% in 150 routine patients.

Claims (3)

1. treat a Chinese medicine composition for the early stage atherosclerotic occlusive disease of Cold-dampness patients with type Ⅰ DM limbs, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 4-8 part, Radix Mirabilis himalaicae 4-8 part, Eriocheir sinensis seven 4-8 part, red Radix Aconiti 6-14 part, Lignum seu Radix Acronychiae 4-8 part, Herba Alyxiae Sinensis 5-13 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 4-8 part, Radix Araliae undulatae 5-13 part, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 5-13 part, Rhizoma Atractylodis macrocephalae 4-8 part, Pericarpium Sterculiae nobilis 6-14 part, gelatinum oxhide 4-8 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 6-14 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine composition of the early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs according to claim 1, is characterized in that, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 5-7 part, Radix Mirabilis himalaicae 5-7 part, Eriocheir sinensis seven 5-7 part, red Radix Aconiti 8-12 part, Lignum seu Radix Acronychiae 5-7 part, Herba Alyxiae Sinensis 7-11 part, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 5-7 part, Radix Araliae undulatae 7-11 part, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 7-11 part, Rhizoma Atractylodis macrocephalae 5-7 part, Pericarpium Sterculiae nobilis 8-12 part, gelatinum oxhide 5-7 part, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 8-12 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine composition of the early stage atherosclerotic occlusive disease for the treatment of Cold-dampness patients with type Ⅰ DM limbs according to claim 3, is characterized in that, be made up of the Chinese medicine of following weight portion:

Fructus Anisi Stellati 6 parts, Radix Mirabilis himalaicae 6 parts, Eriocheir sinensis 76 parts, red Radix Aconiti 10 parts, Lignum seu Radix Acronychiae 6 parts, Herba Alyxiae Sinensis 9 parts, phlegmariurus hamictonii (Sprengel) Love et love varpeti-olaius (Clarke) Ching 6 parts, Radix Araliae undulatae 9 parts, single flower Radix Hyperici Monogyni (Herba Hyperici Monogyni) 9 parts, Rhizoma Atractylodis macrocephalae 6 parts, Pericarpium Sterculiae nobilis 10 parts, gelatinum oxhide 6 parts, Paraphlomis rugosa (Benth.) Prain var. Coronata (Vant.) C. Y. Wu 10 parts, 6 parts, Radix Glycyrrhizae.