CN105010359A - Sterilization composition containing tetramycin and epoxiconazole - Google Patents
Sterilization composition containing tetramycin and epoxiconazole Download PDFInfo
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- CN105010359A CN105010359A CN201510359595.4A CN201510359595A CN105010359A CN 105010359 A CN105010359 A CN 105010359A CN 201510359595 A CN201510359595 A CN 201510359595A CN 105010359 A CN105010359 A CN 105010359A
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- epoxiconazole
- tetramycin
- bactericidal composition
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Abstract
The invention discloses a sterilization composition containing tetramycin and epoxiconazole. The composition contains a pesticide assistant, tetramycin and epoxiconazole, a weight part ratio of tetramycin to epoxiconazole is 1:1-1:80, and the weight sum of tetramycin and epoxiconazole is 1-80% of the weight of the composition. An obvious synergistic effect on pathogen fungi is realized after compounding tetramycin with epoxiconazole, so the composition is suitable for preventing and controlling crop diseases induced by the pathogen fungi, especially rice sheath blight induced by Rhizoctonia solani.
Description
Technical field
The bactericidal composition that the present invention relates to, for active ingredient with tetramycin and epoxiconazole, be applicable to control by the fungus-caused crop pest of pathogen, especially the rice sheath blight disease that causes of Rhizoctonia solani Kuhn (Thanatephoruscucumeris) pathogen.
Background technology
Tetramycin is the biopesticide produced by strain liquid submerged fermentation by S. ahygroscopicus Wuzhou subspecies (Streptomyces ahygroscopicussubsp.Wuzhouensis n.subsp), by suppressing the growth of mycelia, the resistance of induction crop, and promote plant growth and reach to prevent and treat object, be suitable for the control of the multiple fungi of various forest, bacteriosis.
Epoxiconazole, english common name epoxiconazole, chemical name: (2RS, 3SR)-3-(2-chlorphenyl)-2-(4-fluorophenyl)-2-[(1H1,2,4-triazol-1-yl) methyl] oxirane.
Epoxiconazole is a kind of interior absorption triazole bactericidal agent, suppress the synthesis of germ ergosterol, hinder the formation of germ cell wall, and epoxiconazole molecule has powerful compatibility to a kind of fungal enzyme (14-dencthylase), compared with bactericide known at present, can more effectively suppress germ fungal pathogens.Epoxiconazole can improve the chitinase activity of crop, causes the contraction of fungi haustorium, suppresses germ to invade.
Rice sheath blight disease is also known as moire disease, and popular name spends sufficient stalk, rotten pin pest, features spot.Be infected by Rhizoctonia solani Kuhn (Thanatephorus cucumeris) to fall ill, how occur under high temperature, super-humid conditions.Banded sclerotial blight causes harm seriously in South Rice Region of China, is one of Major Diseases in current Rice Production.This disease makes paddy rice not ear, or the not plump paddy of heading is more, and grain heavily declines, and has a strong impact on Rice Production.
Found by test, tetramycin and epoxiconazole combine Rhizoctonia solani (Thanatephoruscucumeris) synergistic function, for the rice sheath blight disease that Rhizoctonia solani Kuhn (Thanatephorus cucumeris) causes.
Can excipient be the formulation agriculturally commonly used by certain technological means tetramycin and epoxiconazole composition.
Summary of the invention
The present invention aims to provide the Synergistic bactericidal composition that a kind of active ingredient is tetramycin and epoxiconazole, for the crop pest that Rhizoctonia solani Kuhn (Thanatephorus cucumeris) causes, especially for rice sheath blight disease provides a kind of effectively management tool.
The present invention is achieved through the following technical solutions: a kind of bactericidal composition containing tetramycin and epoxiconazole, and active ingredient is tetramycin and epoxiconazole, and the ratio of weight and number of tetramycin and epoxiconazole is 1:1 ~ 1:80; Tetramycin and epoxiconazole weight summation percentage by weight are in the composition 1% ~ 80%, and all the other are insecticides adjuvant.
According to practical application needs, bactericidal composition of the present invention, according to well known to a person skilled in the art method, can be prepared as suspending agent, microemulsion.
Described suspending agent formulation by weight percentage consists of: tetramycin 0.01 ~ 10%, epoxiconazole 1 ~ 80%, dispersant 0.1 ~ 18%, wetting agent 0.1 ~ 12%, defoamer 0.1 ~ 3%, thickener 0.1 ~ 3%, antifreezing agent 0.1 ~ 5%, liquid-carrier complements to 100%.Concrete production stage is: by active ingredient and the mixing of other auxiliary agent, after sand milling in high speed shear dispersion, sand mill, form high dispersive, stable suspension system in water-medium, the suspending agent of obtained corresponding weight percentage.
Described micro-emulsion form by weight percentage consists of: tetramycin 0.01 ~ 10%, and epoxiconazole 1 ~ 80%, solvent 0.1 ~ 14%, emulsifier 0.1 ~ 12%, liquid-carrier complements to 100%.Concrete production stage is: active ingredient dissolved, add all the other auxiliary agents, stirring and dissolving, the microemulsion of obtained corresponding weight percentage.
Described defoamer can be one or more in silicone compound, epoxidized soybean oil, methyl alcohol, silicone oil etc.
Described antifreezing agent can be one or more in glycerine, propane diols, diethylene glycol (DEG), urea etc.
Described wetting agent can be one or more in lauryl sodium sulfate, neopelex, sodium butylnaphthalenesulfonate, sodium alkyl sulfonate, the withered powder of tea, spaonin powder, soapberry powder etc.
Described dispersant can be alkylphenol polyoxyethylene formaldehyde condensation products, naphthalenesulfonate formaldehyde condensation compound, to one or more in methoxyl group fatty acyl anilinesulfonic acid, lignosulfonates, polycarboxylate, alkylphenol polyoxyethylene sulphate, alkyl benzene sulfonate calcium salt, fatty acid ester sulphate, alkylphenol polyoxyethylene, fatty alcohol-polyoxyethylene ether, polyethylene glycol stearate, Oleate, nekal etc.
Described thickener can be one or more in polyvinyl acetate, xanthans, gelatin, gum Arabic, aluminium-magnesium silicate, phenolic resins, CMC, sodium alginate etc.
Described liquid-carrier can be one or more in deionized water, exquisite soybean oil, corn oil, rapeseed oil, turpentine oil, methyl oleate, cocoa butter, palm oil, safflower oil, sesame oil, castor oil, tung oil, olive wet goods, and the ester of above vegetable oil, particularly methyl esters.
Described solvent can 2-methyl cellosolve, chloroform, 1, 1, 2-trichloro-ethylene, 1, 2-dimethoxy-ethane, 1, 2, 3, 4-tetrahydronaphthalene, cellosolvo, sulfolane, pyrimidine, formamide, n-hexane, chlorobenzene, dioxane, acetonitrile, carrene, ethylene glycol, N, dinethylformamide, toluene, N, N-dimethylacetylamide, hexahydrotoluene, 1, 2-dichloroethylene, dimethylbenzene, methyl alcohol, cyclohexane, 1-METHYLPYRROLIDONE, pentane, formic acid, acetic acid, ether, acetone, methyl phenyl ethers anisole, methyl oleate, fatty acid methyl ester, pine base oil, soybean oil, biodiesel, ethanol, normal propyl alcohol, isopropyl alcohol, propane diols, glycerine, n-butanol, isooctanol, 2-butyl acetate, dimethyl carbonate, diesel oil, white oil, machine oil, one or more in RPDE etc.
Bactericidal composition of the present invention, for the water prevention rice sheath blight.
Bactericidal composition of the present invention, usually adopts spray method to use, also can adopt other operation techniques agriculturally applied as required.
Bactericidal composition provided by the invention has following beneficial effect:
1, bactericidal composition provided by the invention, obvious synergy or summation action is shown in certain ratio range, the control efficiency of composition to germ is significantly improved than single dose, reduce the using dosage of agricultural chemicals, decrease times for spraying, reduce drug cost, decrease the adverse effect of agricultural chemicals to ecotope.
2, bactericidal composition provided by the invention, the combination of two kinds of active ingredients, expands fungicidal spectrum, and a drug can solve multiple diseases problem, compensate for defect when single dose uses and limitation.
3, bactericidal composition provided by the invention, two kinds of active ingredient mechanism of action are not quite identical, can overcome the shortcoming that long-term single use easily produces resistance, extend the service life of medicament, to the comprehensive regulation important in inhibiting of germ resistance.
4, bactericidal composition provided by the invention, drug effect plays rapidly, and the lasting period is long, and use cost is low, easy to use, time saving and energy saving, and it applies huge economic benefit and social benefit.
Embodiment
In order to make object of the present invention, technical scheme and advantage more short and sweet, the following specific embodiment of the present invention is described, but the present invention is only limitted to absolutely not these embodiments.The following stated is only the good embodiment of the present invention, only for describing the present invention, can not be interpreted as the restriction to scope of the present invention.It should be pointed out that all any amendments done within the spirit and principles in the present invention, equivalent replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Content described in embodiment is all weight percentage.
Embodiment one: tetramycin epoxiconazole is to the Toxicity Determination of pathogenic Rhizoctonia solani Kuhn (Thanatephoruscucumeris).
Subjects picks up from the rice sheath blight disease in field, method reference " People's Republic of China (PRC) agricultural industry criteria NY/T 1156.4-2006 ".
According to the abundant method of Sun Yun, the synergy of pharmacy mix is evaluated according to co-toxicity coefficient (CTC), namely CTC≤80 are joint action of antagonism, and 80 < CTC < 120 are joint action of antagonism, and CTC >=120 are synergistic function.Actual measurement toxicity index (ATI)=(EC of standard agent
50the EC of/reagent agent
50) × 100; In the toxicity index × mixture of theoretical toxicity index TTI=A medicament the percentage composition+B medicament of A medicament toxicity index × mixture in the percentage composition of B medicament; Co-toxicity coefficient (CTC)=[the theoretical toxicity index (TTI) of mixture actual measurement toxicity index (ATI)/mixture] × 100
Table 1, tetramycin epoxiconazole are to the Toxicity Determination result of pathogenic Rhizoctonia solani Kuhn (Thanatephorus cucumeris).
As shown in Table 1, tetramycin and epoxiconazole mixture are between 1:1 ~ 80, and Rhizoctonia solani (Thanatephorus cucumeris) has obvious synergistic effect, and co-toxicity coefficient is all more than 120.Below in conjunction with example of formulations to further instruction of the present invention.
Embodiment two: 5% tetramycin epoxiconazole suspension concentrate.
Above-mentioned formula is pulverized in proportion in advance, then adds in sand mill and grind, the obtained 5% tetramycin epoxiconazole suspension concentrate of allotment after high shear mixing.
The agent of embodiment three: 5% tetramycin epoxiconazole oil microemulsion.
First dissolve epoxiconazole with carrene, add successively acetone, fast T, 602, MP-10, tetramycin, deionized water, add after each single material need stir 20 minutes, namely can be made into 5% tetramycin epoxiconazole microemulsion.
Embodiment four: tetramycin and the epoxiconazole composition water prevention rice sheath blight.
Rice sheath blight disease finds that the initial stage is watered spraying, 10 days, 20 days control efficiency after medicine: 0.1% tetramycin 4.9% epoxiconazole suspension concentrate consumption 45g a.i./ha preventive effect 93.41%, 90.76%; 0.1% tetramycin 4.9% epoxiconazole microemulsion consumption 45g a.i./ha preventive effect 92.18%, 91.27%; 0.15% tetramycin aqua consumption 1.35g a.i./ha preventive effect 83.52%, 79.40%; 125 grams per liter epoxiconazole suspension concentrate consumption 90g a.i./ha preventive effects 86.14%, 82.49%.
Tetramycin and epoxiconazole composition water prevention rice sheath blight successful are better than tetramycin, epoxiconazole single dose, obviously reduce when in combination medicament, the amount ratio of active ingredient is used alone, total active ingredient also reduces relatively, thus alleviate carrying capacity of environment, reduce use cost, for plantation family provides the more efficiently management tool of rice sheath blight disease.
Claims (6)
1. contain a bactericidal composition for tetramycin and epoxiconazole, it is characterized in that: active ingredient is tetramycin and epoxiconazole.
2. a kind of bactericidal composition containing tetramycin and epoxiconazole according to claim 1, is characterized in that: the ratio of weight and number of tetramycin and epoxiconazole is 1:1 ~ 1:80.
3. a kind of bactericidal composition containing tetramycin and epoxiconazole according to claim 1, is characterized in that: tetramycin and epoxiconazole weight summation percentage by weight are in the composition 1% ~ 80%, and all the other are insecticides adjuvant.
4. a kind of bactericidal composition containing tetramycin and epoxiconazole according to claim 1, is characterized in that: the formulation of described bactericidal composition is suspending agent or microemulsion.
5. a kind of bactericidal composition containing tetramycin and epoxiconazole according to claim 1 is preventing and treating the application in the fungus-caused crop pest of pathogen.
6. a kind of application of bactericidal composition in the fungus-caused crop pest of control pathogen containing tetramycin and epoxiconazole according to claim 5, is the application in the microbial rice sheath blight disease of miliary damping-off.
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| CN201510359595.4A CN105010359B (en) | 2015-06-24 | 2015-06-24 | Bactericidal composition containing tetramycin and epoxiconazole |
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| CN201510359595.4A CN105010359B (en) | 2015-06-24 | 2015-06-24 | Bactericidal composition containing tetramycin and epoxiconazole |
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| CN105010359A true CN105010359A (en) | 2015-11-04 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105191956A (en) * | 2015-09-15 | 2015-12-30 | 广东中迅农科股份有限公司 | Pesticide composition containing tetramycin and epoxiconazole |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006938A1 (en) * | 2002-07-12 | 2004-01-22 | The Research Foundation Of State University Of New York | Method for reducing c-rective protein levels with non-antibacterial tetracycline formulations |
| CN103583532A (en) * | 2013-11-26 | 2014-02-19 | 辽宁微科生物工程有限公司 | Tetramycin complex and application |
| CN103636622A (en) * | 2013-12-02 | 2014-03-19 | 海利尔药业集团股份有限公司 | Sterilizing composition containing tetramycin and bromothalonil |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004006938A1 (en) * | 2002-07-12 | 2004-01-22 | The Research Foundation Of State University Of New York | Method for reducing c-rective protein levels with non-antibacterial tetracycline formulations |
| CN103583532A (en) * | 2013-11-26 | 2014-02-19 | 辽宁微科生物工程有限公司 | Tetramycin complex and application |
| CN103636622A (en) * | 2013-12-02 | 2014-03-19 | 海利尔药业集团股份有限公司 | Sterilizing composition containing tetramycin and bromothalonil |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105191956A (en) * | 2015-09-15 | 2015-12-30 | 广东中迅农科股份有限公司 | Pesticide composition containing tetramycin and epoxiconazole |
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