CN105007955B - 适用于植入物的耐用高强度聚合物复合材料及其制品 - Google Patents

适用于植入物的耐用高强度聚合物复合材料及其制品 Download PDF

Info

Publication number
CN105007955B
CN105007955B CN201480014136.6A CN201480014136A CN105007955B CN 105007955 B CN105007955 B CN 105007955B CN 201480014136 A CN201480014136 A CN 201480014136A CN 105007955 B CN105007955 B CN 105007955B
Authority
CN
China
Prior art keywords
valve
leaflet
composite material
elastomer
support construction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201480014136.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN105007955A (zh
Inventor
W·C·布鲁奇曼
P·D·加斯乐
C·L·哈特曼
P·J·沃尔什
C·F·怀特
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
WL Gore and Associates Inc
Original Assignee
WL Gore and Associates Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/798,595 external-priority patent/US9554900B2/en
Application filed by WL Gore and Associates Inc filed Critical WL Gore and Associates Inc
Publication of CN105007955A publication Critical patent/CN105007955A/zh
Application granted granted Critical
Publication of CN105007955B publication Critical patent/CN105007955B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2415—Manufacturing methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
    • A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
    • A61F2/2418—Scaffolds therefor, e.g. support stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2220/00—Fixations or connections for prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2220/0025—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
    • A61F2220/0075—Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0028—Shapes in the form of latin or greek characters
    • A61F2230/0054—V-shaped
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Prostheses (AREA)
  • Materials For Medical Uses (AREA)
CN201480014136.6A 2013-03-13 2014-02-14 适用于植入物的耐用高强度聚合物复合材料及其制品 Expired - Fee Related CN105007955B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/798,595 US9554900B2 (en) 2011-04-01 2013-03-13 Durable high strength polymer composites suitable for implant and articles produced therefrom
US13/798,595 2013-03-13
PCT/US2014/016550 WO2014163795A1 (en) 2013-03-13 2014-02-14 Durable high strength polymer composites suitable for implant and articles produced therefrom

Publications (2)

Publication Number Publication Date
CN105007955A CN105007955A (zh) 2015-10-28
CN105007955B true CN105007955B (zh) 2018-06-22

Family

ID=50193613

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480014136.6A Expired - Fee Related CN105007955B (zh) 2013-03-13 2014-02-14 适用于植入物的耐用高强度聚合物复合材料及其制品

Country Status (8)

Country Link
EP (2) EP2968674B1 (https=)
JP (2) JP6449842B2 (https=)
KR (1) KR20150127127A (https=)
CN (1) CN105007955B (https=)
AU (3) AU2014250034A1 (https=)
CA (1) CA2900656C (https=)
ES (2) ES2801328T3 (https=)
WO (1) WO2014163795A1 (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8579964B2 (en) 2010-05-05 2013-11-12 Neovasc Inc. Transcatheter mitral valve prosthesis
US9554897B2 (en) 2011-04-28 2017-01-31 Neovasc Tiara Inc. Methods and apparatus for engaging a valve prosthesis with tissue
US9308087B2 (en) 2011-04-28 2016-04-12 Neovasc Tiara Inc. Sequentially deployed transcatheter mitral valve prosthesis
US9345573B2 (en) 2012-05-30 2016-05-24 Neovasc Tiara Inc. Methods and apparatus for loading a prosthesis onto a delivery system
US9283072B2 (en) 2012-07-25 2016-03-15 W. L. Gore & Associates, Inc. Everting transcatheter valve and methods
US10376360B2 (en) 2012-07-27 2019-08-13 W. L. Gore & Associates, Inc. Multi-frame prosthetic valve apparatus and methods
US9968443B2 (en) 2012-12-19 2018-05-15 W. L. Gore & Associates, Inc. Vertical coaptation zone in a planar portion of prosthetic heart valve leaflet
US9737398B2 (en) 2012-12-19 2017-08-22 W. L. Gore & Associates, Inc. Prosthetic valves, frames and leaflets and methods thereof
US10966820B2 (en) 2012-12-19 2021-04-06 W. L. Gore & Associates, Inc. Geometric control of bending character in prosthetic heart valve leaflets
US9101469B2 (en) 2012-12-19 2015-08-11 W. L. Gore & Associates, Inc. Prosthetic heart valve with leaflet shelving
US10321986B2 (en) 2012-12-19 2019-06-18 W. L. Gore & Associates, Inc. Multi-frame prosthetic heart valve
US9144492B2 (en) 2012-12-19 2015-09-29 W. L. Gore & Associates, Inc. Truncated leaflet for prosthetic heart valves, preformed valve
US9572665B2 (en) 2013-04-04 2017-02-21 Neovasc Tiara Inc. Methods and apparatus for delivering a prosthetic valve to a beating heart
US9827094B2 (en) 2014-09-15 2017-11-28 W. L. Gore & Associates, Inc. Prosthetic heart valve with retention elements
AU2015382370A1 (en) * 2015-02-13 2017-08-17 W.L. Gore & Associates, Inc. Coherent single layer high strength synthetic polymer composites for prosthetic valves
US10314696B2 (en) 2015-04-09 2019-06-11 Boston Scientific Scimed, Inc. Prosthetic heart valves having fiber reinforced leaflets
US10631984B2 (en) 2015-12-15 2020-04-28 Neovasc Tiara Inc. Transseptal delivery system
EP4183372A1 (en) 2016-01-29 2023-05-24 Neovasc Tiara Inc. Prosthetic valve for avoiding obstruction of outflow
US10368982B2 (en) 2016-05-19 2019-08-06 Boston Scientific Scimed, Inc. Prosthetic valves, valve leaflets and related methods
US10959841B2 (en) 2016-11-15 2021-03-30 Hancock Jaffe Laboratories, Inc. Implantable vein frame
EP3541462A4 (en) 2016-11-21 2020-06-17 Neovasc Tiara Inc. METHODS AND SYSTEMS FOR THE QUICK RETURN OF A TRANSCATHETER HEART VALVE RELEASE SYSTEM
CN106910403B (zh) * 2017-03-29 2019-09-13 广州迈普再生医学科技股份有限公司 血管模型及其制备方法和应用
CN110494170A (zh) 2017-04-25 2019-11-22 波士顿科学国际有限公司 生物相容性聚异丁烯-纤维复合材料和方法
US10952842B2 (en) * 2017-06-07 2021-03-23 W. L. Gore & Associates, Inc. Prosthetic valve with improved washout
CN111263622A (zh) 2017-08-25 2020-06-09 内奥瓦斯克迪亚拉公司 顺序展开的经导管二尖瓣假体
CN111182856B (zh) 2017-09-12 2022-04-29 W.L.戈尔及同仁股份有限公司 用于假体瓣膜的瓣叶框架附连件
CN111163728B (zh) 2017-09-27 2022-04-29 W.L.戈尔及同仁股份有限公司 具有机械联接的瓣叶的假体瓣膜
CN111132636B (zh) 2017-09-27 2022-04-08 W.L.戈尔及同仁股份有限公司 带有可扩张框架的假体瓣膜以及相关系统和方法
US11090153B2 (en) 2017-10-13 2021-08-17 W. L. Gore & Associates, Inc. Telescoping prosthetic valve and delivery system
US11123183B2 (en) 2017-10-31 2021-09-21 W. L. Gore & Associates, Inc. Prosthetic heart valve
EP3703615B1 (en) 2017-10-31 2024-05-15 W. L. Gore & Associates, Inc. Transcatheter deployment systems and associated methods
US11154397B2 (en) * 2017-10-31 2021-10-26 W. L. Gore & Associates, Inc. Jacket for surgical heart valve
US11439502B2 (en) 2017-10-31 2022-09-13 W. L. Gore & Associates, Inc. Medical valve and leaflet promoting tissue ingrowth
WO2019129636A1 (en) * 2017-12-28 2019-07-04 Xeltis, Bv Medical implant preform produced using an inside out flipping method
EP3876870B1 (en) 2018-11-08 2023-12-20 Neovasc Tiara Inc. Ventricular deployment of a transcatheter mitral valve prosthesis
CN109613146A (zh) * 2018-12-08 2019-04-12 苏州贞成分析仪器有限公司 一种吸附脱附管
CN113365671B (zh) * 2019-01-29 2022-09-27 谢尔蒂斯股份公司 用于医疗植入物的电纺覆盖层
US11497601B2 (en) 2019-03-01 2022-11-15 W. L. Gore & Associates, Inc. Telescoping prosthetic valve with retention element
AU2020233892A1 (en) 2019-03-08 2021-11-04 Neovasc Tiara Inc. Retrievable prosthesis delivery system
US11602429B2 (en) 2019-04-01 2023-03-14 Neovasc Tiara Inc. Controllably deployable prosthetic valve
WO2020210652A1 (en) 2019-04-10 2020-10-15 Neovasc Tiara Inc. Prosthetic valve with natural blood flow
JP7381601B2 (ja) 2019-04-12 2023-11-15 エドワーズ ライフサイエンシーズ コーポレイション マルチパートフレーム及び関連するレジリエントブリッジ特徴部を備えた弁
US11779742B2 (en) 2019-05-20 2023-10-10 Neovasc Tiara Inc. Introducer with hemostasis mechanism
CN114222622B (zh) * 2019-06-13 2024-06-21 W.L.戈尔及同仁股份有限公司 具有高固有强度和透光性的轻质膨胀聚四氟乙烯膜
US11311376B2 (en) 2019-06-20 2022-04-26 Neovase Tiara Inc. Low profile prosthetic mitral valve
US12245935B2 (en) 2019-11-26 2025-03-11 Boston Scientific Limited Composite web-polymer heart valve
CN113201222B (zh) * 2021-05-24 2022-08-19 中国科学院西北高原生物研究所 一种牦牛皮胶/pmve-ma复合材料及其制备方法和用途
CN114469451A (zh) * 2021-12-24 2022-05-13 脉通医疗科技(嘉兴)有限公司 瓣膜支架、人工心脏瓣膜及瓣膜支架的制作方法
US20240099834A1 (en) * 2022-09-26 2024-03-28 Medtronic Vascular, Inc. Prosthetic heart valve tissue durability structure and method
CN116251238B (zh) * 2023-02-28 2023-11-21 上海心纪元医疗科技有限公司 具有三层结构的仿生瓣膜瓣叶及其制造方法
CN121177052B (zh) * 2025-11-26 2026-02-17 南开大学 一种一体式带瓣管道及其制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE392582B (sv) 1970-05-21 1977-04-04 Gore & Ass Forfarande vid framstellning av ett porost material, genom expandering och streckning av en tetrafluoretenpolymer framstelld i ett pastabildande strengsprutningsforfarande
US4816339A (en) * 1987-04-28 1989-03-28 Baxter International Inc. Multi-layered poly(tetrafluoroethylene)/elastomer materials useful for in vivo implantation
AU688404B2 (en) 1994-09-02 1998-03-12 W.L. Gore & Associates, Inc. Porous polytetrafluoroethylene compositions
US7049380B1 (en) 1999-01-19 2006-05-23 Gore Enterprise Holdings, Inc. Thermoplastic copolymer of tetrafluoroethylene and perfluoromethyl vinyl ether and medical devices employing the copolymer
US6440164B1 (en) * 1999-10-21 2002-08-27 Scimed Life Systems, Inc. Implantable prosthetic valve
ATE346571T1 (de) * 2000-09-21 2006-12-15 St Jude Medical Ventilprothesen mit blattelementen aus verstärktem kunststoff
US6541589B1 (en) 2001-10-15 2003-04-01 Gore Enterprise Holdings, Inc. Tetrafluoroethylene copolymer
US7641958B2 (en) * 2002-04-25 2010-01-05 Gore Enterprise Holdings, Inc. Membrane for use in sutured or sutureless surgical procedures
US20040024448A1 (en) 2002-08-05 2004-02-05 Chang James W. Thermoplastic fluoropolymer-coated medical devices
US7531611B2 (en) 2005-07-05 2009-05-12 Gore Enterprise Holdings, Inc. Copolymers of tetrafluoroethylene
US7306729B2 (en) 2005-07-18 2007-12-11 Gore Enterprise Holdings, Inc. Porous PTFE materials and articles produced therefrom
US7569071B2 (en) * 2005-09-21 2009-08-04 Boston Scientific Scimed, Inc. Venous valve, system, and method with sinus pocket
AU2007255072A1 (en) * 2006-05-30 2007-12-13 Cook Incorporated Artificial valve prosthesis
US20080220054A1 (en) * 2006-10-13 2008-09-11 Shastri V Prasad Modulation of drug release rate from electrospun fibers
WO2009038761A1 (en) * 2007-09-19 2009-03-26 St. Jude Medical, Inc. Fiber-reinforced synthetic sheets for prosthetic heart valve leaflets
MX339572B (es) * 2009-11-27 2016-05-18 Univ Nac Autónoma De México Materiales compuestos de matriz polimerica con reforzantes de diferentes morfologias y sus procedimientos de sintesis.
US8961599B2 (en) * 2011-04-01 2015-02-24 W. L. Gore & Associates, Inc. Durable high strength polymer composite suitable for implant and articles produced therefrom
US8945212B2 (en) * 2011-04-01 2015-02-03 W. L. Gore & Associates, Inc. Durable multi-layer high strength polymer composite suitable for implant and articles produced therefrom
EP2522308B1 (de) * 2011-05-10 2015-02-25 Biotronik AG Mechanische Transkatheter-Herzklappenprothese

Also Published As

Publication number Publication date
KR20150127127A (ko) 2015-11-16
EP2968674B1 (en) 2018-09-05
JP6449842B2 (ja) 2019-01-09
AU2016269391A1 (en) 2016-12-22
WO2014163795A1 (en) 2014-10-09
CN105007955A (zh) 2015-10-28
CA2900656A1 (en) 2014-10-09
AU2018201999A1 (en) 2018-04-12
AU2014250034A1 (en) 2015-08-13
CA2900656C (en) 2021-05-11
HK1216087A1 (en) 2016-10-14
JP2019058722A (ja) 2019-04-18
ES2701197T3 (es) 2019-02-21
EP2968674A1 (en) 2016-01-20
AU2018201999B2 (en) 2019-07-18
EP3459498B1 (en) 2020-04-01
ES2801328T3 (es) 2021-01-11
JP2016512065A (ja) 2016-04-25
EP3459498A1 (en) 2019-03-27
JP6826093B2 (ja) 2021-02-03

Similar Documents

Publication Publication Date Title
CN105007955B (zh) 适用于植入物的耐用高强度聚合物复合材料及其制品
CN103458934B (zh) 适用于植入物的耐用高强度聚合物复合材料及其制品
CN107206122B (zh) 用于人工瓣膜的连贯单一层高强度合成聚合物复合材料
CN103702636B (zh) 适用于植入物的耐用多层高强度聚合物复合材料及其制品
US10470878B2 (en) Durable high strength polymer composites suitable for implant and articles produced therefrom
CN105188788A (zh) 适用于植入物的耐用多层高强度聚合物复合材料及其制品
HK40004911A (en) Prosthetic heart valve comprising durable high strength polymer composites suitable for implant
HK40004911B (en) Prosthetic heart valve comprising durable high strength polymer composites suitable for implant
HK1216087B (en) Durable high strength polymer composites suitable for implant and articles produced therefrom
HK1188574B (en) Durable high strength polymer composite suitable for implant and articles produced therefrom
HK1188574A (en) Durable high strength polymer composite suitable for implant and articles produced therefrom

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180622

Termination date: 20220214