CN105007931B - 肽在视网膜神经退行性疾病，特别是在糖尿病视网膜病变早期和神经退行性变起重要作用的其它视网膜疾病的局部治疗中的应用 - Google Patents

肽在视网膜神经退行性疾病，特别是在糖尿病视网膜病变早期和神经退行性变起重要作用的其它视网膜疾病的局部治疗中的应用 Download PDF

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Publication number
CN105007931B
CN105007931B CN201480009196.9A CN201480009196A CN105007931B CN 105007931 B CN105007931 B CN 105007931B CN 201480009196 A CN201480009196 A CN 201480009196A CN 105007931 B CN105007931 B CN 105007931B
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peptide
glp
amino acid
retina
retinal
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Chinese (zh)
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CN105007931A (zh
Inventor
拉斐尔·西蒙卡农格
克里斯蒂娜·赫内恩德斯帕斯夸尔
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Fundacio Institut de Recerca Hospital Universitari Vall dHebron
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Fundacio Institut de Recerca Hospital Universitari Vall dHebron
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN201480009196.9A 2013-03-01 2014-02-27 肽在视网膜神经退行性疾病，特别是在糖尿病视网膜病变早期和神经退行性变起重要作用的其它视网膜疾病的局部治疗中的应用 Active CN105007931B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13382063.9 2013-03-01
EP13382063 2013-03-01
PCT/EP2014/053787 WO2014131815A1 (en) 2013-03-01 2014-02-27 Peptides for use in the topical treatment of retinal neurodegenerative disesases, in particular in early stages of diabetic retinopathy and other retinal diseases in which neurodegeneration plays an essential role

Publications (2)

Publication Number Publication Date
CN105007931A CN105007931A (zh) 2015-10-28
CN105007931B true CN105007931B (zh) 2018-04-06

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CN201480009196.9A Active CN105007931B (zh) 2013-03-01 2014-02-27 肽在视网膜神经退行性疾病，特别是在糖尿病视网膜病变早期和神经退行性变起重要作用的其它视网膜疾病的局部治疗中的应用

Country Status (14)

Country Link
US (1) US9707273B2 (https=)
EP (1) EP2968471B1 (https=)
JP (2) JP6368722B2 (https=)
CN (1) CN105007931B (https=)
CA (1) CA2901439C (https=)
DK (1) DK2968471T3 (https=)
ES (1) ES2644016T3 (https=)
HR (1) HRP20171501T1 (https=)
HU (1) HUE036542T2 (https=)
MX (1) MX364911B (https=)
PL (1) PL2968471T3 (https=)
PT (1) PT2968471T (https=)
SI (1) SI2968471T1 (https=)
WO (1) WO2014131815A1 (https=)

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BR112015026910A2 (pt) 2013-04-23 2017-07-25 Procter & Gamble arranjo de ferramenta para consulta de cabelo e método
EP3229828B1 (en) 2014-12-12 2023-04-05 Sanofi-Aventis Deutschland GmbH Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
CN108697768B (zh) 2015-12-23 2022-07-22 约翰霍普金斯大学 长效glp-1r激动剂作为神经系统病状和神经退行性病状的治疗方法
CN108697772B (zh) 2015-12-30 2022-06-24 马歇尔大学科研协会 用于治疗视网膜病的组合物和方法
RU2744878C2 (ru) * 2016-04-29 2021-03-16 Фундасио Оспиталь Университари Валь Д'Эброн - Институт Де Ресерка Ингибиторы дипептидилпептидазы-4 для местного офтальмологического лечения нейродегенеративных заболеваний сетчатки
CN106822182A (zh) * 2016-12-27 2017-06-13 广州姿生生物科技有限公司 一种细胞提取物及其用途
EP3443980A1 (en) * 2017-08-15 2019-02-20 Ciliocure Limited Compound for the treatment of patients with leptin-resistant obesity, bardet-biedl syndrome and other ciliopathies
US20230079395A1 (en) 2020-02-13 2023-03-16 Ferrer Internacional, S.A. Ophthalmic pharmaceutical composition and use thereof
GB202014740D0 (en) * 2020-09-18 2020-11-04 Invex Therapeutics Ltd Method of reducing intraocular pressure
US20220193201A1 (en) * 2020-10-19 2022-06-23 The Trustees Of The University Of Pennsylvania Glp-1r agonist reduces retinal inflammation and neuron death secondary to ocular hypertension
WO2022097156A1 (en) * 2020-11-09 2022-05-12 Tel Hashomer Medical Research Infrastructure And Services Ltd. Treatment of retinal disorders
EP4248985A1 (en) 2022-03-25 2023-09-27 Consejo Superior de Investigaciones Científicas (CSIC) Peptides for the treatment of retinitis pigmentosa

Citations (1)

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Publication number Priority date Publication date Assignee Title
CN102643339A (zh) * 2011-02-21 2012-08-22 天津药物研究院 一种glp-1类似物、制备方法及其应用

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US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
IL128332A0 (en) 1996-08-30 2000-01-31 Novo Nordisk As GLP-1 derivatives
DE122007000044I2 (de) 1997-01-07 2011-05-05 Amylin Pharmaceuticals Inc Verwendung von exedinen und deren antagonisten zur verminderung der lebensmittelaufnahme
WO2003059373A2 (en) 2002-01-16 2003-07-24 Ramot At Tel Aviv University Ltd. Compositions and their use for enhancing and inhibiting fertilization
US20120021980A1 (en) * 2004-08-25 2012-01-26 Aegis Therapeutics, Inc. Compositions for drug administration
US8541413B2 (en) 2004-10-01 2013-09-24 Ramscor, Inc. Sustained release eye drop formulations
WO2007062434A2 (en) 2005-11-22 2007-05-31 Crestwave Technologies (Pty) Ltd A mineral recovery process
CN102076670B (zh) * 2008-06-24 2013-05-22 Irm责任有限公司 调节g蛋白偶联受体的化合物和方法
EP2251028A1 (en) * 2009-05-12 2010-11-17 Biocompatibles Uk Ltd. Treatment of eye diseases using encapsulated cells encoding and secreting an anti-angiogenic factor and/or a neuroprotective factor
ES2362604B1 (es) 2009-12-22 2012-06-28 Bcn Peptides, S.A. Formulación tópica oftálmica de péptidos.

Patent Citations (1)

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CN102643339A (zh) * 2011-02-21 2012-08-22 天津药物研究院 一种glp-1类似物、制备方法及其应用

Also Published As

Publication number Publication date
WO2014131815A1 (en) 2014-09-04
MX364911B (es) 2019-05-13
EP2968471A1 (en) 2016-01-20
MX2015011243A (es) 2016-04-25
BR112015020143A2 (pt) 2017-08-29
PL2968471T3 (pl) 2017-12-29
CA2901439A1 (en) 2014-09-04
JP2018111702A (ja) 2018-07-19
JP2016510728A (ja) 2016-04-11
US9707273B2 (en) 2017-07-18
ES2644016T3 (es) 2017-11-27
EP2968471B1 (en) 2017-07-19
DK2968471T3 (en) 2017-10-23
CN105007931A (zh) 2015-10-28
US20160000882A1 (en) 2016-01-07
HUE036542T2 (hu) 2018-07-30
PT2968471T (pt) 2017-10-24
HRP20171501T1 (hr) 2017-11-17
JP6368722B2 (ja) 2018-08-01
SI2968471T1 (sl) 2017-11-30
CA2901439C (en) 2023-04-04

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