CN104995201B - 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物 - Google Patents

一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物 Download PDF

Info

Publication number
CN104995201B
CN104995201B CN201480002915.4A CN201480002915A CN104995201B CN 104995201 B CN104995201 B CN 104995201B CN 201480002915 A CN201480002915 A CN 201480002915A CN 104995201 B CN104995201 B CN 104995201B
Authority
CN
China
Prior art keywords
water
alkyl
platinum
take
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201480002915.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN104995201A (zh
Inventor
陈小平
高泽军
孟小平
温守明
阎亚矢
赵锋
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Shuobai Pharmaceutical Technology Co.,Ltd.
Original Assignee
BEIJING FENGSHUO WEIKANG TECHNOLOGY DEVELOPMENT Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BEIJING FENGSHUO WEIKANG TECHNOLOGY DEVELOPMENT Co Ltd filed Critical BEIJING FENGSHUO WEIKANG TECHNOLOGY DEVELOPMENT Co Ltd
Priority to CN201480002915.4A priority Critical patent/CN104995201B/zh
Publication of CN104995201A publication Critical patent/CN104995201A/zh
Application granted granted Critical
Publication of CN104995201B publication Critical patent/CN104995201B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201480002915.4A 2013-01-23 2014-01-17 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物 Active CN104995201B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201480002915.4A CN104995201B (zh) 2013-01-23 2014-01-17 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN2013100237224 2013-01-23
CN201310023722 2013-01-23
CN201480002915.4A CN104995201B (zh) 2013-01-23 2014-01-17 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物
PCT/CN2014/000061 WO2014114183A1 (fr) 2013-01-23 2014-01-17 Composé de platine (ii) pour traiter la maladie à prolifération de cellules tumorales

Publications (2)

Publication Number Publication Date
CN104995201A CN104995201A (zh) 2015-10-21
CN104995201B true CN104995201B (zh) 2017-12-22

Family

ID=51226911

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201480002915.4A Active CN104995201B (zh) 2013-01-23 2014-01-17 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物

Country Status (2)

Country Link
CN (1) CN104995201B (fr)
WO (1) WO2014114183A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020043144A1 (fr) 2018-09-01 2020-03-05 北京硕佰医药科技有限责任公司 Phosphate de composé de platine et son procédé de préparation
CN113637031A (zh) * 2020-04-27 2021-11-12 威海海岭生物科技有限公司 一种结构新颖的二价铂类化合物及其用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102781478A (zh) * 2010-02-03 2012-11-14 米韦林有限公司 用于细胞内靶向增殖和蛋白质合成的聚阴离子多价大分子
CN102863474A (zh) * 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8901337B2 (en) * 2009-07-16 2014-12-02 Royal College Of Surgeons In Ireland Metal complexes having dual histone deacetylase inhibitory and DNA-binding activity

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102781478A (zh) * 2010-02-03 2012-11-14 米韦林有限公司 用于细胞内靶向增殖和蛋白质合成的聚阴离子多价大分子
CN102863474A (zh) * 2011-07-09 2013-01-09 陈小平 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Antitumor Platinum(II) Complexes Containing Platinum-Based Moieties of Present Platinum Drugs and Furoxan Groups as Nitric Oxide Donors: Synthesis, DNA Interaction, and Cytotoxicity;Jian Zhao et al.;《Inorg. Chem.》;20120907;第51卷(第9期);第10317-10324页 *

Also Published As

Publication number Publication date
CN104995201A (zh) 2015-10-21
WO2014114183A1 (fr) 2014-07-31

Similar Documents

Publication Publication Date Title
ES2950764T3 (es) Compuestos y composiciones para tratar trastornos hematológicos
CN104768962B (zh) 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物
CN107787323A (zh) 用于抑制shp2活性的化合物和组合物
CN105916845A (zh) 用于抑制shp2活性的n-氮杂螺环烷取代的n-杂芳基化合物和组合物
CN103649100B (zh) 一类离去基团是含氨基或烷胺基的丁二酸衍生物的铂类化合物及其制备方法和应用
CN106659706A (zh) 铂化合物、组合物及其用途
CN103732601B (zh) 一类治疗细胞增殖性疾病的铂化合物、其制备方法和应用
CN104230952B (zh) 含有嘧啶骨架的化合物及其制备方法和用途
US20200405752A1 (en) Antitumor agent, antitumor effect enhancer, and antitumor kit
CN104995201B (zh) 一种治疗肿瘤细胞增生性疾病的铂（ii）类化合物
CN106459011B (zh) 作为抗肿瘤化合物的σ-2受体配体药物缀合物、其合成方法及其用途
CN102688489B (zh) 含有雷公藤甲素及雷公藤甲素类衍生物和Bcl-2抑制剂的药物组合物及其应用
CN103703011B (zh) 一类离去基团是含氨基或烷氨基的羟基酸衍生物的铂类化合物及其制备方法和应用
JPWO2013146437A1 (ja) ３−デセン酸誘導体およびその用途
US20100152154A1 (en) Novel platinum compounds for treating cancer
US20090105206A1 (en) Copper Melphalan And Copper Tegafur As Anti-Tumor Agents
ES2372242B1 (es) Compuesto di{3,5-diacetil-1,2,4-triazol bis(4-ciclohexil tiosemicarbazonato)platino (ii)}, procedimiento de síntesis y su aplicación como fármaco antitumoral.
CN110339200A (zh) 一种茴三硫衍生物的应用
Basnet Modern Medicine and Pharmaceutics

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant
TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20210624

Address after: 101102 Beijing Tongzhou District Zhongguancun Science and Technology Park Tongzhou Garden Jinqiao Science and Technology Industrial Base No. 16, 12 blocks, 4 floors, 401

Patentee after: Beijing Shuobai Pharmaceutical Technology Co.,Ltd.

Address before: 100850 Room 502, bingmen, building 23, 27 Taiping Road, Haidian District, Beijing

Patentee before: BEIJING FSWELCOME TECHNOLOGY DEVELOPMENT Co.,Ltd.