CN104984422A - Double-X-ray-source blood irradiator - Google Patents
Double-X-ray-source blood irradiator Download PDFInfo
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- CN104984422A CN104984422A CN201510442649.3A CN201510442649A CN104984422A CN 104984422 A CN104984422 A CN 104984422A CN 201510442649 A CN201510442649 A CN 201510442649A CN 104984422 A CN104984422 A CN 104984422A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
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- Heart & Thoracic Surgery (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Abstract
The invention provides a double-X-ray-source blood irradiator, and belongs to the field of blood irradiators. The double-X-ray-source blood irradiator comprises an irradiation cavity and X-ray sources disposed in the irradiation cavity and a blood bag container used for containing a blood bag. The blood bag contains blood or a blood product to be irradiated. Two X-ray sources are respectively arranged over and under the blood bag container, and the two X-ray sources are staggered relative to a horizontal projective plane. The inner wall of the irradiation cavity is provided with an X-ray reflecting layer. The two X-ray sources are staggered in the double-X-ray-source blood irradiator, so the area of a uniform radiation field can be raised, so that the area where a blood bag can be put can be raised, the X-ray sources can be fully used.
Description
Technical field
The present invention relates to blood irradiator technical field, particularly relate to a kind of two x-ray source blood irradiation device.
Background technology
Transfusion-associated graft versus host disease (TA-GVHD) be immunodeficiency or immunosuppressant patient can not remove input blood in there is immunocompetent lymphocyte, it is made to plant alive, propagation in vivo, the histoorgan of patient is identified as non-own material, and carries out a kind of mortality complication of blood transfusion of immune attack, destruction as target.TA-GVHD clinical manifestation lacks specificity, very easily fails to pinpoint a disease in diagnosis and mistaken diagnosis.
There are some researches show that causing the receptor of TA-GVHD to input lymphocyte quantity should be greater than 10
7/ kg, if lower than 10
5/ kg then can not cause TA-GVHD.But there is report to the child of immunodeficiency only 10
4namely/kg lymphocyte causes TA-GVHD.Lymphocyte quantity its state of an illness more inputting donor are in a word more serious, and mortality rate is also higher.
Thinking at present and irradiate blood product before transfusing blood, is the only effective method of prevention TA-GVHD.Its mechanism is: lymphocyte, to radiation-sensitive, by the roentgenization of suitable dosage, can make immunocompetent lymphocytes deactivation, loses multiplication capacity.And it is little on the impact of erythrocyte, hematoblastic function and coagulation factor activity.Present developed country utility ratio reaches 30% ~ 40%.
Blood irradiator is exactly a kind of use roentgenization blood or blood product, carries out deactivation to lymphocyte, the armarium of TA-GVHD disease in prevention blood transfusion activity.
Divide from radiographic source, blood irradiator can be divided into two classes, and a class is the gamma-rays irradiation of blood or blood products that adopt radioactive source (mainly Cs-137, Co-60) to produce, and a class is the x-ray bombardment blood or blood product adopting X-ray tube to produce.Radioactive source type blood irradiator equipment needs to assemble the isotope radioactive source of hundreds of to upper kilocurie, and this also exists potential nuclear leakage risk.X source type blood irradiator does not then have the risk of nuclear leakage, and device powers down just produces without any ray.
But, there is the uneven shortcoming of X-ray energy low, single source irradiation in X source type blood irradiator, can not meet the requirement (the heterogeneity <20% of Standard blood irradiator irradiation) to uniformity of radiation in blood irradiator standard.The X-ray energy that common X source produces is generally at below 200keV, and it is in irradiation of blood or blood products process, is easy to be absorbed in a large number by the blood of shallow-layer, and the X-ray quantum count arriving depths is reduced rapidly.
In order to overcome the shortcoming of single source irradiation X source type blood irradiator, the scheme of double source irradiation is suggested.By placing an X source in the upper and lower both direction symmetry of blood bag, it can significantly improve the uniformity of irradiation.But as shown in Figure 1, because the radiation field homogeneity range of two its horizontal direction of X source scheme is limited, make in whole irradiation field, to have sub-fraction region can place blood bag and accept irradiation, and the ray in most of region is all wasted.
Summary of the invention
For the problems referred to above, the object of this invention is to provide a kind of two x-ray source blood irradiation device, comprising:
Irradiation cavity, and be arranged on the x-ray source of irradiation inside cavity and the blood bag for containing blood letting bag, blood or blood product to be irradiated is carried in described blood bag, the quantity of described x-ray source is two or more, it is arranged at top and the below of blood bag respectively, and between two x-ray sources, stagger mutually in its position on horizontal plane, the inwall of described irradiation cavity is provided with X ray reflection layer.
Further, the outside of described irradiation cavity is provided with X-ray absorbed layer.
Further, the quantity of described x-ray source is two.
Further, the material that the element that described X ray reflection layer is less than 10 by atomic number forms is formed.
Further, described X ray reflection layer is made up of polyethylene.
Further, the material that the element that described X-ray absorbed layer is greater than 50 by atomic number forms is formed.
Further, described X-ray absorbed layer is made up of heavy metal material.
Further, described heavy metal material is plumbous, tungsten.
Further, the thickness of described X ray reflection layer is less than 10CM.
The present invention is a kind of two x-ray source blood irradiation device, and it increases the area of homogeneous radiation field by mutually being staggered by upper and lower two X sources, thus increases the area can placing blood or blood product, more abundant to the utilization of X source.
Accompanying drawing explanation
Fig. 1 is the schematic diagram of irradiation dose field intensity of the prior art;
Fig. 2 is overall structure principle schematic in the present invention;
Fig. 3 is the schematic diagram of irradiation dose field intensity in the present invention;
Fig. 4 is the schematic diagram of two x-ray source position relationships in the present invention.
Detailed description of the invention
Below in conjunction with drawings and the specific embodiments, the present invention is further detailed explanation.
Refer to Fig. 2 to Fig. 4, one embodiment of the invention provides a kind of two x-ray source blood irradiation device, comprising:
Irradiation cavity, and be arranged on the x-ray source of irradiation inside cavity and the blood bag 5 for containing blood letting bag, blood or blood product to be irradiated is carried in described blood bag, the quantity of described x-ray source is two or more, it is arranged at top and the below of blood bag 5 respectively, and between two x-ray sources, stagger mutually in its position on horizontal plane, the inwall of described irradiation cavity is provided with X ray reflection layer 3.
Preferably, the quantity of described x-ray source is two.
Place because the first X source 1 and the second X source 2 stagger, its dosage field intensity that will the dosage field intensity in the first front 6 and the second region, front 9 made to be greater than first back side 7 and the second region, the back side 8.Thisly be partially absorbed dosage field heterogeneity caused by the higher limit lower than national regulations due to ray, meet the requirement of GB.And because energy is lower than X-ray of 511keV and matter interaction, main generation two kinds of effects, one is photoelectric effect, and another kind is compton effect,scattering.The atomic number of material is higher, photoelectric ratio occurs higher; The atomic number of material is less, and the ratio that compton effect,scattering occurs is higher.In irradiation cavity shielded box inside, X ray reflection layer 3 is set, it is the material of low atomic number, can allow originally by flee from irradiation cavity shielded box X-ray some be reflected back toward in irradiation cavity, it will improve the utilization ratio of X-ray further, and the dosage field intensity that blood or blood product to be irradiated deviates from x-ray source one side can be increased, reduce the gradient of blood or blood product positive and negative to be irradiated dosage field, the uniformity of increasing dose field.
When two x-ray source horizontal ranges are far away, the dosage field intensity of two x-ray source lines and the intersection point O of blood plane to be irradiated is by lower at the subpoint A1 of blood plane than x-ray source.Therefore, the theoretical maximum of two x-ray source horizontal ranges is the dosage field intensity of O point is 80% of A1 point.
Further, the outside of described irradiation cavity is provided with X-ray absorbed layer 4.And for the X-ray through X ray reflection layer 3, in order to avoid they pollute surrounding, so adopt X-ray absorbed layer 4 to absorb it.
Further, the material that the element that described X ray reflection layer 3 is less than 10 by atomic number forms is formed, and makes it be beneficial to the generation of compton effect,scattering, thus X-ray in X-ray is had more easily be reflected back toward in irradiation cavity.
Further, described X ray reflection layer 3 is made up of polyethylene.
Further, the material that the element that described X-ray absorbed layer 4 is greater than 50 by atomic number forms is formed, and X-ray in X-ray is had and is more easily absorbed.
Further, described X-ray absorbed layer 4 is made up of heavy metal material.
Further, described heavy metal material is plumbous, tungsten.
Further, the thickness of described X ray reflection layer 3 is less than 10CM.Make it can meet the reflection demand of X-ray, the small size of Whole Equipment can be kept again.
The above, only embodiments of the invention, not any pro forma restriction is done to the present invention, although the present invention discloses as above with embodiment, but and be not used to limit the present invention, any those skilled in the art, do not departing within the scope of technical solution of the present invention, make a little change when the technology contents of above-mentioned announcement can be utilized or be modified to the Equivalent embodiments of equivalent variations, in every case be do not depart from technical solution of the present invention content, according to any simple modification that technical spirit of the present invention is done above embodiment, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.
Claims (9)
1. a two x-ray source blood irradiation device, it is characterized in that, comprise: irradiation cavity, and being arranged on the x-ray source of irradiation inside cavity and the blood bag for containing blood letting bag, carry blood or blood product to be irradiated in described blood bag, the quantity of described x-ray source is two or more, it is arranged at top and the below of blood bag respectively, and between two x-ray sources, stagger mutually in its position on horizontal plane, the inwall of described irradiation cavity is provided with X ray reflection layer.
2. two x-ray source blood irradiation device as claimed in claim 1, it is characterized in that, the outside of described irradiation cavity is provided with X-ray absorbed layer.
3. two x-ray source blood irradiation device as claimed in claim 1, it is characterized in that, the quantity of described x-ray source is two.
4. two x-ray source blood irradiation device as claimed in claim 1, it is characterized in that, the material that the element that described X ray reflection layer is less than 10 by atomic number forms is formed.
5. two x-ray source blood irradiation device as claimed in claim 4, it is characterized in that, described X ray reflection layer is made up of polyethylene.
6. two x-ray source blood irradiation device as claimed in claim 2, it is characterized in that, the material that the element that described X-ray absorbed layer is greater than 50 by atomic number forms is formed.
7. two x-ray source blood irradiation device as claimed in claim 6, it is characterized in that, described X-ray absorbed layer is made up of heavy metal material.
8. two x-ray source blood irradiation device as claimed in claim 7, is characterized in that, described heavy metal material is plumbous, tungsten.
9. the two x-ray source blood irradiation devices as described in claim 3,5 or 8, it is characterized in that, the thickness of described X ray reflection layer is less than 10CM.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201510442649.3A CN104984422A (en) | 2015-07-24 | 2015-07-24 | Double-X-ray-source blood irradiator |
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|---|---|---|---|
| CN201510442649.3A CN104984422A (en) | 2015-07-24 | 2015-07-24 | Double-X-ray-source blood irradiator |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597179A (en) * | 2016-02-24 | 2016-05-25 | 江苏摩科特医疗科技有限公司 | Blood irradiator, dosage monitoring system and irradiation dosage measuring method |
| CN109006744A (en) * | 2018-06-20 | 2018-12-18 | 广东省农业科学院植物保护研究所 | Citrus fruit fly irradiates processing system and the processing method of preventing epidemic of not sprouting wings |
| CN109481765A (en) * | 2018-12-14 | 2019-03-19 | 山东新华医疗器械股份有限公司 | X-ray blood irradiator |
| CN110237322A (en) * | 2019-06-27 | 2019-09-17 | 江苏同威信达技术有限公司 | Double source X-ray blood irradiator and its operating method |
| EP4214567A4 (en) * | 2021-04-19 | 2023-11-29 | Varex Imaging Corporation | Systems and methods for irradiation |
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| CN101360522A (en) * | 2005-12-19 | 2009-02-04 | Lumen联合公司 | Apparatus for irradiation of fluid with electromagnetic radiation and method for the same |
| CN103861164A (en) * | 2012-12-15 | 2014-06-18 | 钱捷 | Ultraviolet irradiation blood therapy instrument |
| CN104307060A (en) * | 2014-10-22 | 2015-01-28 | 中国科学院苏州生物医学工程技术研究所 | X-ray blood irradiator |
| CN104324425A (en) * | 2014-10-17 | 2015-02-04 | 中国科学院苏州生物医学工程技术研究所 | Blood irradiation instrument |
| CN204840428U (en) * | 2015-07-24 | 2015-12-09 | 江苏摩科特医疗科技有限公司 | Two X ray source blood irradiation apparatus |
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2015
- 2015-07-24 CN CN201510442649.3A patent/CN104984422A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101360522A (en) * | 2005-12-19 | 2009-02-04 | Lumen联合公司 | Apparatus for irradiation of fluid with electromagnetic radiation and method for the same |
| CN103861164A (en) * | 2012-12-15 | 2014-06-18 | 钱捷 | Ultraviolet irradiation blood therapy instrument |
| CN104324425A (en) * | 2014-10-17 | 2015-02-04 | 中国科学院苏州生物医学工程技术研究所 | Blood irradiation instrument |
| CN104307060A (en) * | 2014-10-22 | 2015-01-28 | 中国科学院苏州生物医学工程技术研究所 | X-ray blood irradiator |
| CN204840428U (en) * | 2015-07-24 | 2015-12-09 | 江苏摩科特医疗科技有限公司 | Two X ray source blood irradiation apparatus |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105597179A (en) * | 2016-02-24 | 2016-05-25 | 江苏摩科特医疗科技有限公司 | Blood irradiator, dosage monitoring system and irradiation dosage measuring method |
| CN109006744A (en) * | 2018-06-20 | 2018-12-18 | 广东省农业科学院植物保护研究所 | Citrus fruit fly irradiates processing system and the processing method of preventing epidemic of not sprouting wings |
| CN109481765A (en) * | 2018-12-14 | 2019-03-19 | 山东新华医疗器械股份有限公司 | X-ray blood irradiator |
| CN110237322A (en) * | 2019-06-27 | 2019-09-17 | 江苏同威信达技术有限公司 | Double source X-ray blood irradiator and its operating method |
| CN110237322B (en) * | 2019-06-27 | 2024-05-24 | 同威信达技术(江苏)股份有限公司 | Dual-source X-ray blood irradiation instrument and operation method thereof |
| EP4214567A4 (en) * | 2021-04-19 | 2023-11-29 | Varex Imaging Corporation | Systems and methods for irradiation |
| CN117222937A (en) * | 2021-04-19 | 2023-12-12 | 万睿视影像有限公司 | System and method for irradiation |
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