CN104984392B - 一种肌肉组织修复材料及其制备方法 - Google Patents
一种肌肉组织修复材料及其制备方法 Download PDFInfo
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- CN104984392B CN104984392B CN201510352421.5A CN201510352421A CN104984392B CN 104984392 B CN104984392 B CN 104984392B CN 201510352421 A CN201510352421 A CN 201510352421A CN 104984392 B CN104984392 B CN 104984392B
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- 239000000463 material Substances 0.000 title claims abstract description 56
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000012153 distilled water Substances 0.000 claims abstract description 22
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 15
- 229920001661 Chitosan Polymers 0.000 claims abstract description 15
- 239000004471 Glycine Substances 0.000 claims abstract description 15
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract description 15
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 15
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 15
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 15
- 102000007469 Actins Human genes 0.000 claims abstract description 14
- 108010085238 Actins Proteins 0.000 claims abstract description 14
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims abstract description 14
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims abstract description 14
- 239000004474 valine Substances 0.000 claims abstract description 14
- 102000016359 Fibronectins Human genes 0.000 claims abstract description 13
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 13
- 102000003505 Myosin Human genes 0.000 claims abstract description 12
- 108060008487 Myosin Proteins 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 239000002131 composite material Substances 0.000 claims description 42
- 239000002002 slurry Substances 0.000 claims description 42
- 239000013078 crystal Substances 0.000 claims description 21
- 239000002245 particle Substances 0.000 claims description 21
- 102000011782 Keratins Human genes 0.000 claims description 11
- 108010076876 Keratins Proteins 0.000 claims description 11
- 238000002844 melting Methods 0.000 claims description 7
- 230000008018 melting Effects 0.000 claims description 7
- 238000010792 warming Methods 0.000 claims description 6
- 239000000835 fiber Substances 0.000 claims description 2
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 claims 1
- 102000002322 Egg Proteins Human genes 0.000 claims 1
- 108010000912 Egg Proteins Proteins 0.000 claims 1
- 102100034263 Mucin-2 Human genes 0.000 claims 1
- 108010008705 Mucin-2 Proteins 0.000 claims 1
- 235000014103 egg white Nutrition 0.000 claims 1
- 210000000969 egg white Anatomy 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 3
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- 210000003205 muscle Anatomy 0.000 description 12
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- 102000006395 Globulins Human genes 0.000 description 3
- 108010044091 Globulins Proteins 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
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- 229920000642 polymer Polymers 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
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- Cosmetics (AREA)
- Materials For Medical Uses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Description
应力/kPa | 含水量/% | 与人体正常皮肤融合情况 | |
实施例1 | 56 | 75 | 较佳 |
实施例2 | 70 | 84 | 完全融合 |
实施例3 | 63 | 76 | 完全融合 |
Claims (7)
Priority Applications (1)
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CN201510352421.5A CN104984392B (zh) | 2015-06-24 | 2015-06-24 | 一种肌肉组织修复材料及其制备方法 |
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CN201510352421.5A CN104984392B (zh) | 2015-06-24 | 2015-06-24 | 一种肌肉组织修复材料及其制备方法 |
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CN104984392A CN104984392A (zh) | 2015-10-21 |
CN104984392B true CN104984392B (zh) | 2017-09-12 |
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Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2010040129A2 (en) * | 2008-10-03 | 2010-04-08 | Trustees Of Tufts College | Scaffolds for tissue engineering and regenerative medicine |
WO2011075183A1 (en) * | 2009-12-15 | 2011-06-23 | Vanderbilt University | Injectable/in situ forming tissue polyurethane composites and methods thereof |
CN101851425A (zh) * | 2010-04-21 | 2010-10-06 | 广东工业大学 | 一种温敏性高分子水凝胶及其制备方法 |
EP2611471B1 (en) * | 2010-08-30 | 2018-10-03 | President and Fellows of Harvard College | A high strength chitin composite material and method of making |
CN102704041A (zh) * | 2012-05-21 | 2012-10-03 | 复旦大学 | 一种取向螺旋碳纳米管纤维及其制备方法和用途 |
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