CN104983950A - Traditional Chinese medicine for treating spleen and kidney deficiency type chronic pyelonephritis, and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine for treating spleen and kidney deficiency type chronic pyelonephritis, and a preparation method thereof. Raw medicinal materials of the traditional Chinese medicine comprise Sorbus pohuashanensis, Chinese Aralia Bark and Root-bark, Ficus esquiroliana, Shorthairy Antenoron Herb, Dahurian Rose Fruit, Herb of Ivy Glorybind, Phyllanthus virgatus Forst. f., Polygonum posumbu, Lespedeza bicolor Turcz, Polygala aureocauda Dunn, Root of Membranaceous Beautyleaf, Morinda umbellata L., root of Woods Greenstar, stem and leaf of Wallich Pepper and Rhizome of Largeleaf Curculigo. The traditional Chinese medicine has a definite therapeutic effect on the spleen and kidney deficiency type chronic pyelonephritis, and has small toxic side effects.

Description

A kind of Chinese medicine and preparation method for the treatment of spleen kidney both deficiency type chronic pyelonephritis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or mineral component, particularly relating to a kind of Chinese medicine and preparation method for the treatment of spleen kidney both deficiency type chronic pyelonephritis.

Background technology

Chronic pyelonephritis (CPN) is the chronic inflammatory disease that bacteriological infection kidney causes, and pathological changes mainly invades renal interstitial, renal pelvis and renal calices tissue.The infringement carrying out or repeatedly cause renal interstitial, renal pelvis and renal calices is continued due to inflammation, form cicatrix, so that also there is dysfunction in kidney generation atrophy, its main manifestations is heating, weak, inappetence, the soreness of waist, lumbago, frequent micturition, urgent micturition, dysurea and dysuria, and nocturia increases and urine protein etc.Patient has urinary tract infection history that is long-term or recurrent exerbation.

Chronic pyelonephritis belongs to the category such as Chinese medicine " edema ", " asthenia ".Due to nephropathy with the passing of time, healthy energy is gradually empty, and edema delay is not moved back, or leads to edema recurrent exerbation because of reasons such as overstrain, flu, diet, and spleen kidney regulates water malfunction at night, and causes cold-damp impairment of YANG, and spleen kidney is impaired.

Summary of the invention

Technical problem to be solved by this invention is, provide a kind of Chinese medicine and preparation method for the treatment of spleen kidney both deficiency type chronic pyelonephritis, Chinese medicine of the present invention has definite curative effect to spleen kidney both deficiency type chronic pyelonephritis, and toxic and side effects is little.

In order to solve the problems of the technologies described above, the invention provides a kind of Chinese medicine for the treatment of spleen kidney both deficiency type chronic pyelonephritis, its raw medicinal material comprises: Fructus Sorbi Pohuashanensis Radix araliae chinensis (Cortex Araliae Chinensis), Ficus fulva Reinw., Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), rose hip, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Phyllanthus simplex Retz．, Herba Polygoni caespitosi, Caulis Seu Folium Lespedezae Bicoloris, Radix Polygalae fallacis, Radix calophylli membranacei, Radix Morindae Umbellatae, Polyalthia nemoralis A. D C., Caulis et Folium piperis and Rhizoma Curculiginis Capitulatae.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Fructus Sorbi Pohuashanensis 5 ~ 15 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 20 parts, Ficus fulva Reinw. 15 ~ 25 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, rose hip 10 ~ 20 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 45 parts, Phyllanthus simplex Retz． 10 ~ 20 parts, Herba Polygoni caespitosi 5 ~ 15 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 15 parts, Radix Polygalae fallacis 25 ~ 35 parts, Radix calophylli membranacei 15 ~ 25 parts, Radix Morindae Umbellatae 10 ~ 20 parts, Polyalthia nemoralis A. D C. 35 ~ 45 parts, Caulis et Folium piperis 25 ~ 35 parts and Rhizoma Curculiginis Capitulatae 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Sorbi Pohuashanensis 5 ~ 10 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 15 parts, Ficus fulva Reinw. 15 ~ 20 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, rose hip 10 ~ 15 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 40 parts, Phyllanthus simplex Retz． 10 ~ 15 parts, Herba Polygoni caespitosi 5 ~ 10 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 10 parts, Radix Polygalae fallacis 25 ~ 30 parts, Radix calophylli membranacei 15 ~ 20 parts, Radix Morindae Umbellatae 10 ~ 15 parts, Polyalthia nemoralis A. D C. 35 ~ 40 parts, Caulis et Folium piperis 25 ~ 30 parts and Rhizoma Curculiginis Capitulatae 15 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Fructus Sorbi Pohuashanensis 6 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 12 parts, Ficus fulva Reinw. 18 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 7 parts, rose hip 14 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 39 parts, Phyllanthus simplex Retz． 13 parts, Herba Polygoni caespitosi 8 parts, Caulis Seu Folium Lespedezae Bicoloris 7 parts, Radix Polygalae fallacis 26 parts, Radix calophylli membranacei 18 parts, Radix Morindae Umbellatae 11 parts, Polyalthia nemoralis A. D C. 36 parts, Caulis et Folium piperis 28 parts and Rhizoma Curculiginis Capitulatae 16 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Fructus Sorbi Pohuashanensis 8 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 14 parts, Ficus fulva Reinw. 17 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 8 parts, rose hip 11 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 36 parts, Phyllanthus simplex Retz． 12 parts, Herba Polygoni caespitosi 5 parts, Caulis Seu Folium Lespedezae Bicoloris 10 parts, Radix Polygalae fallacis 29 parts, Radix calophylli membranacei 16 parts, Radix Morindae Umbellatae 13 parts, Polyalthia nemoralis A. D C. 39 parts, Caulis et Folium piperis 26 parts and Rhizoma Curculiginis Capitulatae 20 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Beneficial effect of the present invention: Chinese medicine of the present invention has definite curative effect to spleen kidney both deficiency type chronic pyelonephritis, and toxic and side effects is little.

Detailed description of the invention

The invention provides a kind of Chinese medicine for the treatment of spleen kidney both deficiency type chronic pyelonephritis, its raw medicinal material comprises: Fructus Sorbi Pohuashanensis ， Radix araliae chinensis (Cortex Araliae Chinensis), Ficus fulva Reinw., Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), rose hip, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Phyllanthus simplex Retz．, Herba Polygoni caespitosi, Caulis Seu Folium Lespedezae Bicoloris, Radix Polygalae fallacis, Radix calophylli membranacei, Radix Morindae Umbellatae, Polyalthia nemoralis A. D C., Caulis et Folium piperis and Rhizoma Curculiginis Capitulatae.

In described Chinese medicine, the pharmacology of each raw medicinal material is as follows:

Fructus Sorbi Pohuashanensis: fruit, stem and peel of stem that [source] sets for rosaceous plant Fructus Sorbi Pohuashanensis.[nature and flavor] are sweet, bitter, flat.[function cures mainly] relieving cough and expelling phlegm, invigorating spleen for diuresis.Control chronic tracheitis, pulmonary tuberculosis, edema.

Radix araliae chinensis (Cortex Araliae Chinensis): [source] adds root or the root bark of section Zhi Wu Cortex araliae chinensis for Wu.[nature and flavor] are pungent, flat.[function cures mainly] wind-damp dispelling, diuresis, dissipating blood stasis blood, detumescence poison.Treating rheumatic arthritis, oedema due to nephritis, cirrhotic ascites, acute, chronic hepatitis, stomachache, stranguria with turbid discharge, metrorrhagia, traumatic injury, scrofula, carbuncle.

Ficus fulva Reinw.: [source] is the root bark of moraceae plants Ficus fulva Reinw..[nature and flavor] are sweet, and property is put down.[function cures mainly] QI invigorating, spleen invigorating, dispels the wind, dehumidifying.The main deficiency of vital energy, the prolapse of the uterus, proctoptosis, loose stool, edema, rheumatic arthralgia.

Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis): [source] is polygonaceae plant Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), the herb of undercoat Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis).[nature and flavor] are pungent, bitter, cool in nature.[function cures mainly] cooling blood for hemostasis, clearing away heat-damp and promoting diuresis, eliminating stasis to stop pain.Main hemoptysis, spit blood, have blood in stool, metrorrhagia, has loose bowels, dysentery, stomachache, abdominal pain in menstruation, puerperal abdominal pain due to blood stasis, traumatic injury, rheumatic arthralgia, scrofula, carbuncle.

Rose hip: [source] is rosaceous plant Rosa bella, the fruit of light leaf Rosa bella.[nature and flavor] acid, bitter, temperature.[return through] returns liver, spleen, stomach, urinary bladder channel.[function cures mainly] strengthening the spleen to promote digestion, promoting blood flow to regulate menstruation, astringing lung-QI and relieving cough.Main dyspepsia, inappetence, abdominal distention, diarrhoea, menoxenia, dysmenorrhea, atherosclerosis, pulmonary tuberculosis is coughed.

Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae): the herb that [source] is convolvulaceous plant DAWANHUA or root.[nature and flavor] are sweet, micro-hardship, flat.[return through] returns liver, kidney channel.[function cures mainly] spleen invigorating, dampness removing, regulating menstruation.Main weakness of the spleen and stomach, dyspepsia, infantile milk regurgitation, infantile malnutrition, five types of stranguria, leukorrhagia, menoxenia.

Phyllanthus simplex Retz．: [source] is the herb of euphorbia plant Phyllanthus simplex Retz．.[nature and flavor] are sweet, bitter, flat.[return through] returns spleen channel.[function cures mainly] spleen invigorating removing food stagnancy, inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing.Main infantile malnutrition, dysentery, gonorrhea, acute mastitis, ulcerative gingivitis, venom.

Herba Polygoni caespitosi: [source] is the herb of polygonaceae plant Herba Polygoni caespitosi.[nature and flavor] are pungent, and property is put down.[function cures mainly] heat clearing and damp drying, spleen invigorating disappears infantile malnutrition, promoting blood flow to regulate menstruation, removing toxic substances and promoting subsidence of swelling.Master has loose bowels, dysentery, infantile malnutrition, menoxenia, eczema, tinea pedis, venom.

Caulis Seu Folium Lespedezae Bicoloris: [source] is the branch and leaf of leguminous plant Caulis Seu Folium Lespedezae Bicoloris.[nature and flavor] are sweet, flat.[return through] GUIXIN, Liver Channel.[function cures mainly] clearing heat and moistening lung, inducing diuresis for treating stranguria syndrome, hemostasis.Main cough due to lung-heat, cold, fever, pertussis, stranguria, spit blood, epistaxis, hematuria, has blood in stool.

Radix Polygalae fallacis: root, stem, leaf that [source] is milk wort Radix Polygalae fallacis.[nature and flavor] are sweet, micro-hardship, and property is put down.[return through] returns liver, spleen, kidney channel.The spleen invigorating of [function cures mainly] tonify deficiency, dissipating blood stasis dredging collateral.Main overstrain is weak, uterine prolapse, infantile malnutrition, edema due to deficiency of the spleen, and leukorrhagia is rare clearly, rheumatic arthralgia, lumbago, has through uncomfortable, dysmenorrhea, traumatic injury.

Radix calophylli membranacei: [source] is the root of Garcinia maingayii Calophyllum membranaceum Gardn. et Champ.[nature and flavor] micro-hardship, flat.[return through] returns liver, kidney channel.[function cures mainly] wind-damp dispelling, bone and muscle strengthening, promoting blood circulation and stopping pain.Main air wet numbness, lumbago due to renal deficiency, menoxenia, dysmenorrhea, traumatic injury.

Radix Morindae Umbellatae: the root that [source] is Maguireothamnus speciosus Radix Morindae Umbellatae or root bark.[nature and flavor] are pungent, micro-sweet, temperature.[return through] returns kidney channel.[function cures mainly] expelling wind and removing dampness, reinforcing the kidney and arresting hemorrhage.Main rheumatic arthritis, lumbago due to renal deficiency, sexual impotence, stomachache.

Polyalthia nemoralis A. D C.: [source] is the root of annonaceae plant Lingshui Polyalthia suberosa (Roxb.) Thw.[nature and flavor] are sweet, flat.[return through] returns spleen, stomach, kidney channel.[function cures mainly] strengthens the spleen and stomach, nourishing kidney controlling nocturnal emission with astringent drugs.Main chronic gastritis, taste lose, inappetence, myasthenia of limbs, seminal emission.

Caulis et Folium piperis: the stem and leaf that [source] is Piperaceae plant Caulis et Folium piperis or Herb.[nature and flavor] are pungent, temperature, sweet.[return through] returns liver, spleen, small intestine meridian.[function cures mainly] wind-damp dispelling, strong waist knee joint, kidney invigorating and YANG supporting, relieving cough and asthma, promoting blood circulation and stopping pain.Main anemofrigid-damp arthralgia, soreness of waist and knee joint, sexual impotence, cough and asthma, dysmenorrhea, treating swelling and pain by traumatic injury.

Rhizoma Curculiginis Capitulatae: [source] is the rhizome of bloodwort great Ye Rhizoma Curculiginis.[nature and flavor] are pungent, micro-hardship, temperature.[return through] returns kidney, lung, Liver Channel.[function cures mainly] kidney invigorating and YANG supporting, expelling wind and removing dampness, promoting blood flow to regulate menstruation.Main cough with asthma of suffering from a deficiency of the kidney, impotence and seminal emission, nebulousurine leukorrhagia, soreness of the waist and knees, rheumatic arthralgia, cold womb is infertile, menoxenia, metrorrhagia, uterine prolapse, traumatic injury.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material is as follows: Fructus Sorbi Pohuashanensis 5 ~ 15 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 20 parts, Ficus fulva Reinw. 15 ~ 25 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, rose hip 10 ~ 20 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 45 parts, Phyllanthus simplex Retz． 10 ~ 20 parts, Herba Polygoni caespitosi 5 ~ 15 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 15 parts, Radix Polygalae fallacis 25 ~ 35 parts, Radix calophylli membranacei 15 ~ 25 parts, Radix Morindae Umbellatae 10 ~ 20 parts, Polyalthia nemoralis A. D C. 35 ~ 45 parts, Caulis et Folium piperis 25 ~ 35 parts and Rhizoma Curculiginis Capitulatae 15 ~ 25 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material can be preferably: Fructus Sorbi Pohuashanensis 5 ~ 10 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 15 parts, Ficus fulva Reinw. 15 ~ 20 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, rose hip 10 ~ 15 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 40 parts, Phyllanthus simplex Retz． 10 ~ 15 parts, Herba Polygoni caespitosi 5 ~ 10 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 10 parts, Radix Polygalae fallacis 25 ~ 30 parts, Radix calophylli membranacei 15 ~ 20 parts, Radix Morindae Umbellatae 10 ~ 15 parts, Polyalthia nemoralis A. D C. 35 ~ 40 parts, Caulis et Folium piperis 25 ~ 30 parts and Rhizoma Curculiginis Capitulatae 15 ~ 20 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Fructus Sorbi Pohuashanensis 6 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 12 parts, Ficus fulva Reinw. 18 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 7 parts, rose hip 14 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 39 parts, Phyllanthus simplex Retz． 13 parts, Herba Polygoni caespitosi 8 parts, Caulis Seu Folium Lespedezae Bicoloris 7 parts, Radix Polygalae fallacis 26 parts, Radix calophylli membranacei 18 parts, Radix Morindae Umbellatae 11 parts, Polyalthia nemoralis A. D C. 36 parts, Caulis et Folium piperis 28 parts and Rhizoma Curculiginis Capitulatae 16 parts.

In described Chinese medicine, the ratio of weight and number of each raw medicinal material also can be preferably: Fructus Sorbi Pohuashanensis 8 Fen ， Radix araliae chinensis (Cortex Araliae Chinensis) 14 parts, Ficus fulva Reinw. 17 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 8 parts, rose hip 11 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 36 parts, Phyllanthus simplex Retz． 12 parts, Herba Polygoni caespitosi 5 parts, Caulis Seu Folium Lespedezae Bicoloris 10 parts, Radix Polygalae fallacis 29 parts, Radix calophylli membranacei 16 parts, Radix Morindae Umbellatae 13 parts, Polyalthia nemoralis A. D C. 39 parts, Caulis et Folium piperis 26 parts and Rhizoma Curculiginis Capitulatae 20 parts.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

Present invention also offers the preparation method of above-mentioned Chinese medicine, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

Below adopt embodiment to describe embodiments of the present invention in detail, fully understand how application technology means solve technical problem in the present invention whereby, reach technique effect and implement according to this.

Embodiment 1 tablet

Get Fructus Sorbi Pohuashanensis 60g ， Radix araliae chinensis (Cortex Araliae Chinensis) 120g, Ficus fulva Reinw. 180g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 70g, rose hip 140g, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 390g, Phyllanthus simplex Retz． 130g, Herba Polygoni caespitosi 80g, Caulis Seu Folium Lespedezae Bicoloris 70g, Radix Polygalae fallacis 260g, Radix calophylli membranacei 180g, Radix Morindae Umbellatae 110g, Polyalthia nemoralis A. D C. 360g, Caulis et Folium piperis 280g and Rhizoma Curculiginis Capitulatae 160g;

The first step: each for described Chinese medicine preparation raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 5 times is the ethanol of 90%, reflux 2 hours, extract, filter acquisition first extracting solution, it is the ethanol of 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 3 times again, reflux 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize and sieve acquisition 200 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.3 times, the lactose of 0.1 times, the starch of 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, dry, add the magnesium stearate relative to micropowders quality 0.05 times, granulate, tabletting, makes.

Embodiment 2 powder

Get Fructus Sorbi Pohuashanensis 80g ， Radix araliae chinensis (Cortex Araliae Chinensis) 140g, Ficus fulva Reinw. 170g, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 80g, rose hip 110g, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 360g, Phyllanthus simplex Retz． 120g, Herba Polygoni caespitosi 50g, Caulis Seu Folium Lespedezae Bicoloris 100g, Radix Polygalae fallacis 290g, Radix calophylli membranacei 160g, Radix Morindae Umbellatae 130g, Polyalthia nemoralis A. D C. 390g, Caulis et Folium piperis 260g and Rhizoma Curculiginis Capitulatae 200g;

Prepare according to the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 times is the ethanol of 85%, reflux 2 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 2 times again, reflux 1 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 hour, pulverize, sieve, obtain 200 object micropowders;

3rd step: add the starch relative to its quality 4 times in the micropowders obtained by second step, mixing, obtains powder.

Toxicity test:

Acute toxicity testing: application mice 60, male and female half and half, body weight 18-24g, carries out acute toxicity test.Mice is divided into two groups at random, i.e. matched group and administration group, before experiment, fasting 12 hours, is dissolved in water by Chinese medicinal tablet prepared by embodiments of the invention 1, (concentration is 8.48g crude drug/ml, maximum concentration) gavage, gavage volume is 5ml/kg (namely unit dosage form is 42.4 crude drugs/kg), and matched group gives normal saline, administration in one day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: compare with matched group, and after administration, mice has no notable difference, and experiment Continuous Observation 14 days, mouse systemic situation, diet, drinking-water, body weight increase all normal.Mouse oral gavage tablet LD50>42.4 crude drug/kg of the present invention, every day, maximum dosage-feeding was 84.8 crude drugs/kg/ day.Chinese medicine clinical application amount of the present invention be 8.4g crude drug/day/people, adult body weight in 60KG, average dosage is 0.14g crude drug/kg/ day.By weighing machine: the dosis tolerata of mice (average weight is in 21g) oral administration gavage Chinese medicine of the present invention is 606 times of quantity.Therefore Chinese medicine acute toxicity of the present invention is extremely low, clinical drug safety.

Long term toxicity test: Chinese medicine embodiment 1 tablet of the present invention presses 13.88,22.32 and 43.56g crude drug/kg continuous use 15 weeks (1.0ml/100g body weight to mice, every day 2 times) and drug withdrawal after 3 weeks, result shows: the index such as hair, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat of Chinese medicine of the present invention to mice all has no significant effect, internal organs naked eyes do not find that difference change and histological indications show, medication 15 weeks and drug withdrawal are after 3 weeks, and Organs of Mice is all without obviously changing.Illustrate that Chinese medicine of the present invention is little to toxicity after mice long-term prescription, also there is no difference reaction after drug withdrawal, application safety.

Clinical data:

Case selection: whole 115 routine cases are my Out-patient Department and inpatient of in May, 2012 ~ in December, 2014.Patient is divided into treatment group and matched group at random.Wherein treatment group 60 example, male 24 example, women 36 example, 32 ~ 77 years old age, average (51.9 ± 2.5) year, the course of disease 1 ~ 8 year, average (3.6 ± 0.6) year; Matched group 55 example, male 21 example, women 34 example, 33 ~ 76 years old age, average (50.8 ± 1.3) year, the course of disease 1 ~ 8 year, average (3.4 ± 0.9) year.Two groups in age, the course of disease, symptom and coincident with severity degree of condition etc. through statistical analysis there was no significant difference (p>0.05).

Diagnostic criteria:

Western medicine diagnose standard: the chronic pyelonephritis diagnostic criteria of formulating with reference to the academic conference of Second China National nephropathy.(1) there is obvious urinary irritation symptoms in stage of attack in medical history, urine positive bacterial culture, and frequently send out author, but at present can without obvious urinary irritation symptoms.(2) normal CCMS routine examination in early morning leukocyte can not increase, urine positive bacterial culture.(3) B-ultrasonic renal is visible: kidney profile is uneven, two inequality in size of kidneys, and aggregation system arrangement disorder.(4) nocturnal urine output can be had many, urine relative density is low, and pH value increases.

Tcm syndrome differentiation and typing standard: spleen kidney both deficiency type: namely frequent micturition, urgent micturition, dysurea fatigue are sent out, soreness of the waist and knees, fatigue and weakness, and shallow complexion is simple and unadorned, light red tongue, white and thin fur, deep-thready pulse.

Therapeutic Method

Matched group: (1) general treatment: have high hot person to lie up, encourage to drink more water, duty is urinated, and impels antibacterial and inflammatory exudate to get rid of in time.(2) antibacterials: according to bacterial strain and drug sensitivity tests, specific aim medication, conventional anti-gram negative bacilli medicine, as bactrim 2, every day 2 times is oral, nitrofurantoin 0.1g, and every day 3 times is oral, cefradine 0.25 ~ 0.5g, every day 4 times, norfloxacin 0.2g, every day 3 times.Fever, the obvious person of General Symptoms can use gentamycin 80,000 u, every day 2 times, intramuscular injection.Bacillus pyocyaneus and Proteus Infection person can with Carbenicillin or sulbenicillins, and the course for the treatment of is 2 weeks.

Treatment group: (1) general treatment: have high hot person to lie up, encourage to drink more water, duty is urinated, and impels antibacterial and inflammatory exudate to get rid of in time.(2) oral each 3 of Chinese medicine embodiment 1 tablet of the present invention, every day 3 times.The course for the treatment of is 2 weeks.

Curative effect judging standard:

Cure: the disappearance of clinical symptoms, sign, routine urinalysis is normal, and within 6 weeks, check urine antibacterial culturing is negative, terminates the nothing recurrence in 6 months of rear follow-up study the course for the treatment of.

Effective: clinical symptoms, sign disappear or substantially disappear, routine urinalysis is normal or close normal, and within 6 weeks, check urine antibacterial culturing is negative, terminates the nothing recurrence in 6 months of rear follow-up study the course for the treatment of.

Effective: clinical symptoms, sign are obviously improved, routine urinalysis is normal or close to normal, within 6 weeks, check urine antibacterial culturing occasionally has the positive, terminates recidivist in rear follow-up study 6 months the course for the treatment of.

Invalid: clinical symptoms and routine urinalysis are not improved, urine antibacterial culturing thinks positive.

Therapeutic outcome: before and after two groups of treatments, total effects compares, in table 1.

Table 1: before and after two groups of treatments, total effects is compared as follows:

Group	n	Cure	Effective	Effectively	Invalid	Effectively total
							Treatment group	60	28	20	8	4	56(93.33％)
Matched group	55	12	15	18	10	45(81.82％)

Note: treatment group compares with matched group, treatment group curative effect is better than matched group (P<0.05).

Concrete case: become certain, women, 51 years old.Soreness of the waist and knees, fatigue and weakness, shallow complexion is simple and unadorned.The recurrent exerbation such as urinary irritation symptoms 4 years half, check: urine positive bacterial culture, and B-ultrasonic renal is visible: kidney profile is uneven, two inequality in size of kidneys, and aggregation system arrangement disorder.Light red tongue, white and thin fur, deep-thready pulse.Be diagnosed as chronic pyelonephritis, Syndrome Types of TCM is spleen kidney both deficiency type.Give each 3 of Chinese medicine embodiment 1 tablet of the present invention, every day 3 times, treat recovery from illness after 2 weeks, within 6 weeks, check urine antibacterial culturing is negative.Follow up a case by regular visits to and do not recur half a year.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims (8)

1. treat a Chinese medicine for spleen kidney both deficiency type chronic pyelonephritis, it is characterized in that, each raw medicinal material of described Chinese medicine comprises: Fructus Sorbi Pohuashanensis; Radix araliae chinensis (Cortex Araliae Chinensis), Ficus fulva Reinw., Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis), rose hip, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Phyllanthus simplex Retz．, Herba Polygoni caespitosi, Caulis Seu Folium Lespedezae Bicoloris, Radix Polygalae fallacis, Radix calophylli membranacei, Radix Morindae Umbellatae, Polyalthia nemoralis A. D C., Caulis et Folium piperis and Rhizoma Curculiginis Capitulatae.

2. Chinese medicine as claimed in claim 1, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Fructus Sorbi Pohuashanensis 5 ~ 15 parts of Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 20 parts, Ficus fulva Reinw. 15 ~ 25 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 15 parts, rose hip 10 ~ 20 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 45 parts, Phyllanthus simplex Retz． 10 ~ 20 parts, Herba Polygoni caespitosi 5 ~ 15 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 15 parts, Radix Polygalae fallacis 25 ~ 35 parts, Radix calophylli membranacei 15 ~ 25 parts, Radix Morindae Umbellatae 10 ~ 20 parts, Polyalthia nemoralis A. D C. 35 ~ 45 parts, Caulis et Folium piperis 25 ~ 35 parts and Rhizoma Curculiginis Capitulatae 15 ~ 25 parts.

3. Chinese medicine as claimed in claim 1 or 2, it is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Fructus Sorbi Pohuashanensis 5 ~ 10 parts of Radix araliae chinensis (Cortex Araliae Chinensis) 10 ~ 15 parts, Ficus fulva Reinw. 15 ~ 20 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 5 ~ 10 parts, rose hip 10 ~ 15 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 35 ~ 40 parts, Phyllanthus simplex Retz． 10 ~ 15 parts, Herba Polygoni caespitosi 5 ~ 10 parts, Caulis Seu Folium Lespedezae Bicoloris 5 ~ 10 parts, Radix Polygalae fallacis 25 ~ 30 parts, Radix calophylli membranacei 15 ~ 20 parts, Radix Morindae Umbellatae 10 ~ 15 parts, Polyalthia nemoralis A. D C. 35 ~ 40 parts, Caulis et Folium piperis 25 ~ 30 parts and Rhizoma Curculiginis Capitulatae 15 ~ 20 parts.

4. the Chinese medicine as described in claims 1 to 3, is characterized in that, the ratio of weight and number of each raw medicinal material of described Chinese medicine is as follows: Fructus Sorbi Pohuashanensis 6 parts of Radix araliae chinensis (Cortex Araliae Chinensis) 12 parts, Ficus fulva Reinw. 18 parts, Herba Antenoronis Neofiliformis (Herba Antenoronis Filiformis) 7 parts, rose hip 14 parts, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 39 parts, Phyllanthus simplex Retz． 13 parts, Herba Polygoni caespitosi 8 parts, Caulis Seu Folium Lespedezae Bicoloris 7 parts, Radix Polygalae fallacis 26 parts, Radix calophylli membranacei 18 parts, Radix Morindae Umbellatae 11 parts, Polyalthia nemoralis A. D C. 36 parts, Caulis et Folium piperis 28 parts and Rhizoma Curculiginis Capitulatae 16 parts.

5. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

6. the Chinese medicine as described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.

7. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is tablet, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine preparation raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 3 ~ 5 times is the ethanol of 80 ~ 90%, reflux 1 ~ 2 hour, extract, filter acquisition first extracting solution, it is the ethanol of 80 ~ 90% that the medicinal residues that filtration obtains add relative to the determining alcohol of medicinal residues quality 1 ~ 3 times again, reflux 35 ~ 45 minutes, extract, filter acquisition second extracting solution, the first extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, drying, obtains and gets dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize and sieve acquisition 200 ~ 300 object micropowders;

3rd step: add relative to the microcrystalline Cellulose of its quality 0.1 ~ 0.3 times, the lactose of 0.05 ~ 0.15 times, the starch of 0.1 ~ 0.3 times in the micropowders that second step obtains, sieve, mix homogeneously, granulate, drying, adds the magnesium stearate relative to micropowders quality 0.005 ~ 0.05 times, granulate, tabletting, makes.

8. a preparation method for Chinese medicine described in Claims 1-4, is characterized in that, the dosage form of described Chinese medicine is powder, and its preparation method comprises the following steps:

The first step: each for described Chinese medicine raw medicinal material is mixed in proportion, adding relative to the determining alcohol of mixture quality 2 ~ 3 times is the ethanol of 75 ~ 85%, reflux 2 ~ 3 hours, extracts, and filters acquisition first extracting solution; It is the ethanol of 75 ~ 85% that the medicinal residues that filtration obtains add relative to the determining alcohol of described medicinal residues quality 1 ~ 2 times again, reflux 1 ~ 2 hour, extracts, and filters acquisition second extracting solution; First extracting solution and the second extracting solution are merged, concentrating under reduced pressure removing alcohol solvent, dry, obtain and get dry extract;

Second step: the dry cream that the first step obtains is placed in super micron mill and pulverizes 1 ~ 2 hour, pulverize, sieve, obtain 100 order ~ 200 object micropowders;

3rd step: add the starch relative to its quality 2 ~ 4 times in the micropowders obtained by second step, mixing, obtains powder.