CN104970804B - Continuous percutaneous micropin monitoring system - Google Patents
Continuous percutaneous micropin monitoring system Download PDFInfo
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- CN104970804B CN104970804B CN201410128351.0A CN201410128351A CN104970804B CN 104970804 B CN104970804 B CN 104970804B CN 201410128351 A CN201410128351 A CN 201410128351A CN 104970804 B CN104970804 B CN 104970804B
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- micropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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Abstract
The present invention discloses a kind of continuous percutaneous micropin monitoring system, this monitoring system includes:Substrate, microneedle unit, signal processing unit and power supply unit.Microneedle unit, which includes at least, to be arranged on substrate as the first micropin group of working electrode and as the second micropin group with reference to electrode, each micropin group includes at least a micropin, first micropin group includes an at least thin slice, one perforation is at least set on each thin slice, perforated edge is provided with a bur, perforation wherein on a thin slice is passed through for the bur of the perforated edge of relative position on remaining thin slice, and those burs are disconnected from each other.The micropin of the present invention has enough mechanical strengths, and when the micropin of micropin group, which punctures skin, to be sensed, micropin can remain intact.
Description
Technical field
The present invention relates to transcutaneous sensor, measures subcutaneous concentration of target molecules particularly with regard to one kind to know that human body is given birth to
Manage the percutaneous micropin sensor of signal.
Background technology
Subcutaneous tissue is the main place of human tissue liquid flow distribution, and being rich in tissue fluid has Amino acid, sugar, fat
Waste that acid, coenzyme, hormone, neurotransmitter, salt and cell produce etc., is the main pipe that cell is exchanged with blood, therefore logical
The concentration of each composition in tissue fluid is crossed, is to judge one of method of physiological status
Take or during injection medicine, medicine can be in tissue fluid for a long time and slowly release, in drug development and use
Clinical trial during, often need constantly to monitor the change of medicine concentration in tissue fluid, also therefore sampling tissue fluid with
It is detected or analyzes, is seen everywhere in medical procedure.
Physiological detection equipment seen by market now, or the method for medical staff's sampling tissue liquid, adopt and have an acupuncture treatment and wear mostly
Broken cuticula, carrys out extracting interstitial fluid to carry out analysis detection, but such a sampling method for destroying skin surface, except easily making
Patient feels pain, and then germinate outside rejection feeling, a large amount of microorganisms of skin surface, also easily in the destroyed feelings of skin surface
Under condition, into human body and then infection.In order to improve acupuncture treatment and wear out the shortcomings that cuticula samples, there is proposition transcutaneous sensor, its
Skin penetrating is carried out using the micropin of array format, low invasive puncture can effectively mitigate the feeling of pain of user, and together
When achieve the purpose that sample tissue fluid.
The micropin making of transcutaneous sensor is common to be had using the semiconductor technologies such as lithographic and etching, such as United States Patent (USP) US7,
Disclose a kind of technique of silicon micropin in the 2nd section of the 12nd column of specification of 344,499B1.First, there is provided thereon covered with patterned
One Silicon Wafer of the first photoresist layer.Then, it is etched using isotropic etching mode, forms a perforation.Then, in wafer
Surface is coated with one second photoresist layer of a layers of chrome, afterwards coated pattern, so that being covered in perforation, and forms a circle
Shielding supplies subsequent etch.Then, it is etched to form the outer cone wall of micropin.However, due to the brittleness containing silicon semiconductor material,
When micropin, which punctures skin, to be sensed, micropin is easily broken off.
In addition, there is the mode proposed using Laser Micro-Machining, drill to the bur that resin is formed, to make hollow microneedles.
First, extrusion molding is carried out using such as polyimide resin or polyether-ether-ketone resin, is formed thin with multiple burs thereon
Piece, then drills bur using laser, you can obtain hollow microneedles.However, since micropin size is superfine small, during extrusion molding
Bur is there may be flash, and whether off-axis perforation or central hole, and it is not easy to form unified aperture using laser.
The content of the invention
It is an object of the invention to provide a kind of continuous percutaneous micropin monitoring system, the micropin of its micropin group is set to puncture skin
When being sensed, micropin can remain intact.
In order to reach above-mentioned purpose, the present invention provides a kind of continuous percutaneous micropin monitoring system, this monitoring system includes:
Substrate, microneedle unit, signal processing unit and power supply unit.Microneedle unit, which includes at least to be arranged on substrate, is used as working electrode
The first micropin group, and as the second micropin group with reference to electrode, each micropin group includes at least a micropin, the first micropin group
Comprising an at least thin slice, a perforation is at least set, perforated edge is provided with a bur, wherein wearing on a thin slice on each thin slice
Hole is passed through for the bur of the perforated edge of relative position on remaining thin slice, and those burs are disconnected from each other.Signal processing unit
It is arranged on the substrate and is electrically connected with the first micropin group and the second micropin group.Power supply unit supply working power gives this
Monitoring system.
Wherein, which is stacked and is formed by one first thin slice and one second thin slice, is at least set on first thin slice
One first perforation is put, which, which is provided with one first bur, and second thin slice, at least sets one second perforation,
Second perforated edge is provided with one second bur, first perforation of second bur through relative position on first thin slice
It is opposite with first bur.
Wherein, which is stacked and is formed by one first thin slice, one second thin slice and one the 3rd thin slice, this is first thin
On piece at least sets one first perforation, which is provided with one first bur, one is at least set on second thin slice
Second perforation, which is provided with one second bur, and one the 3rd perforation is at least set on the 3rd thin slice, this
Three perforated edges are provided with one the 3rd bur, and second bur and the 3rd bur pass through first perforation on first thin slice
It is in triangular pyramidal with first bur.
Wherein, the first micropin group be stacked by one first thin slice, one second thin slice, one the 3rd thin slice and one the 4th thin slice and
Into, at least set on first thin slice one first perforation, which is provided with one first bur, on second thin slice
One second perforation is at least set, which is provided with one second bur, one the 3rd is at least set on the 3rd thin slice
Perforation, the 3rd perforated edge, which is provided with one the 3rd bur and the 4th thin slice, at least sets one the 4th perforation, and the 4th wears
Bore edges are provided with one the 4th bur, and second bur, the 3rd bur and the 4th bur pass through being somebody's turn to do on first thin slice
First perforation and first bur are in corner taper.
Wherein, each bur of the first micropin group includes a point and a substrate, wherein the perforation warp on a thin slice
The top of the point for the micropin that the bur of the perforated edge of relative position is formed after passing through on remaining thin slice does not exist
Sustained height.
Wherein, each bur of the first micropin group includes a point and a substrate, wherein the perforation warp on a thin slice
The top of the point for the micropin that the bur of the perforated edge of relative position is formed after passing through on remaining thin slice has
Sustained height.
Wherein, the micropin of the first micropin group and the second micropin group is formed by punching press or etch process.
Wherein, sensing macromolecule is scribbled on the inner surface of the bur.
Wherein, the medicine of anti-skin allergy is scribbled on the outer surface of the bur.
Wherein, a test-paper is further included, is placed between the first micropin group and the substrate, it is conductive which includes one
Layer and multiple test zones on the conductive layer, coating sensing macromolecule on the test zone, and with first micropin
Perforation alignment in group.
Wherein, a protective layer is further included to be formed on the medicine of sensing macromolecule or anti-skin allergy.
Wherein, the material of the bur is selected from stainless steel, nickel, nickel alloy, titanium, titanium alloy, carbon nanotubes or silicon materials, and
In metal of the surface deposition with bio-compatibility.
Wherein, the material of the bur is resin, and in metal of the surface deposition with bio-compatibility.
Wherein, one the 3rd micropin group is further included as counterelectrode.
The present invention also provides a kind of sensing device further of interstitial fluid, and the micropin of its micropin group is by punching press or etch process shape
Into, there is enough mechanical strengths, when micropin group micropin puncture skin sensed when, micropin can remain intact.Moreover, this
The structure of the working electrode micropin group of invention is conducive to sensing macromolecule being coated on the inner surface of micropin point, in work electricity
When the micropin puncture skin of atomic pin group is sensed, the high molecular peeling of sensing can be reduced.
The sensing device further of the interstitial fluid of the present invention, includes substrate and microneedle unit.Microneedle unit includes at least and is arranged in base
The first micropin group and the second micropin group on plate, wherein the first micropin group is as working electrode, those micropins of the first micropin group
It is arranged in the form of an array on the substrate, for the second micropin group as referring to electrode, the second micropin group includes at least a micropin, and first
Micropin group includes an at least thin slice, at least sets a perforation on each thin slice, perforated edge is provided with a bur, wherein a thin slice
On perforation passed through for the bur of the perforated edge of relative position on remaining thin slice, and those burs are disconnected from each other.
Compared to the prior art, continuous percutaneous micropin monitoring system provided by the present invention, the micropin of its micropin group by
Punching press or etch process are formed, and have enough mechanical strengths, when the micropin of micropin group, which punctures skin, to be sensed, micropin energy
Remain intact.In addition, the structure of the working electrode micropin group of the present invention is conducive to sensing macromolecule being coated on micropin point
Inner surface, when the micropin of working electrode micropin group punctures skin and sensed, the high molecular peeling of sensing can be reduced.And
And the technique of microneedle unit of the invention is simple, be conducive to largely produce.
Below in conjunction with the drawings and specific embodiments, the present invention will be described in detail, but not as a limitation of the invention.
Brief description of the drawings
Fig. 1 is that continuously percutaneous micropin monitors the explosive decomposition Tu ﹔ of system to one embodiment of the invention
Fig. 2 is that continuously percutaneous micropin monitors the explosion point of system with one embodiment of the invention of Fig. 1 difference view directions
Xie Tu；
Fig. 3 is the Shi Yi Tu ﹔ of one embodiment of the invention microneedle unit
Fig. 4 is the structure partial top view of one embodiment of the invention working electrode micropin group；
Fig. 5 is the structure partial top view of another embodiment of the present invention working electrode micropin group；
Fig. 6 is the structure partial top view of another embodiment of the present invention working electrode micropin group；
Fig. 7 is the structure partial top view of the still another embodiment working electrode micropin group of the present invention；
Fig. 8 is that continuously percutaneous micropin monitors the combination schematic appearance of system to one embodiment of the invention；
Fig. 9 is that continuously percutaneous micropin monitors the combination diagrammatic cross-section of system to one embodiment of the invention；
Figure 10 is the partial cutaway schematic of Fig. 9, wherein sensing macromolecule is coated on the bur of micropin；
Figure 11 is the partial cutaway schematic of Fig. 9, wherein sensing macromolecule is coated on test-paper；
Figure 12 is that continuously percutaneous micropin monitors the combination partial cutaway schematic of system to one embodiment of the invention, wherein leading
Handle is directly electrically connected through part bending with the contact on circuit board, and without using conductive column.
Wherein, reference numeral：
10 substrate, 102 hole
104 slot, 20 microneedle unit
21st, 23,25 conductive column, 22 first micropin group
222 first thin slice, 2221 point
2222 first 2223 substrates of perforation
2224 first bur, 224 second thin slice
2242 second 2,244 second burs of perforation
2246 barbs 2248 lead handle
226 the 3rd thin slices 2262 the 3rd are perforated
The 4th thin slice of 2264 the 3rd bur 228
2282 the 4th 2284 the 4th burs of perforation
24 second micropin group, 242 first thin slice
2422 first 2,424 first burs of perforation
2426 barbs 2428 lead handle
26 the 3rd micropin group, 262 first thin slice
2622 first 2,624 first burs of perforation
2626 barbs 2628 lead handle
30 flexible gaskets 32 are open
40 circuit board, 41 signal processing unit
42nd, 44,46 electric contact, 43 power supply unit
50 outer cover, 92 conductive layer
94 test zone, 96 resin sheet
98 adhesion layers
Embodiment
Detailed description for the present invention and technology contents, coordinate schema to be described as follows, but institute's accompanying drawings only provide ginseng
Examine and used with explanation, be not used for being any limitation as the present invention.
Referring to Fig.1 and 2, for respectively to watch one embodiment of the invention by different directions continuous percutaneous micro- by Fig. 1 and Fig. 2
Pin monitors the explosive decomposition figure of system.The continuous percutaneous micropin monitoring system of the present invention includes:Substrate 10, microneedle unit 20, can
Flexible gasket 30, signal processing unit 41, power supply unit 43 and outer cover 50, wherein signal processing unit 41 and power supply unit 43 are set
It is placed on circuit board 40.
An embodiment according to the present invention, microneedle unit 20, which includes, to be arranged on substrate 10 as the first micro- of working electrode
Pin group 22, the second micropin group 24 as reference electrode, and the 3rd micropin group 26 as counterelectrode.First micropin group 22
Those micropins may, for example, be array format and be arranged on substrate 10.There is an opening 32 to supply microneedle unit on flexible gasket 30
20 by the way that and microneedle unit 20 is electrically connected with the electric contact 42,44,46 on conductive column 21,23,25 and circuit board 40.Due to
The present invention has a flexible gasket 30, and when operation can be in close contact with the muscle profile syntype of user.
Signal processing unit 41 is electrically connected with microneedle unit 20 to receive the concentration of target molecules of micropin sensing, through computing
After judgement, a sensing signal, and a kind of signal that can reflect the physiological status of user instantly are converted the information into.Power supply
Unit 43 supplies power for operation to the continuous percutaneous micropin monitoring system of the present invention.
Fig. 3 is refer to, Fig. 3 is the schematic diagram of one embodiment of the invention microneedle unit.First micropin group 22 is thin by first
222 and second thin slice 224 of piece is stacked to be formed, and one first perforation 2222 is at least set on the first thin slice 222, first perforation 2222
Edge, which is provided with one first bur 2224, and the second thin slice 224, at least sets one second perforation 2242, and the second perforated edge is set
It is equipped with one second bur 2244, first perforation 2222 and first of second bur 2244 through relative position on the first thin slice 222
Bur 2224 is opposite.In addition, barb 2246 and the hole on substrate 10 can be set on 224 edge of the second thin slice of first micropin group 22
Cave 102 engages.It can be set in an embodiment, 224 edge of the second thin slice of the first micropin group 22 and lead the insertion substrate 10 of handle 2248
On slot 104, be electrically connected by circuit and conductive column 21.
Similarly, the second micropin group 24 also has the first thin slice 242, and one first perforation is at least set on the first thin slice 242
2422, the first perforated edge is provided with one first bur 2424.In addition, can on 242 edge of the first thin slice of the second micropin group 24
Barb 2426 is set to engage with the hole 102 on substrate 10.At an embodiment, 242 edge of the first thin slice of the second micropin group 24
On can set lead handle 2428 be inserted into substrate 10 on slot 104, be electrically connected by circuit and conductive column 23.
Similarly, the 3rd micropin group 26 also has the first thin slice 262, and one first perforation is at least set on the first thin slice 262
2622, the first 2622 edges of perforation are provided with one first bur 2624.In addition, 262 edge of the first thin slice of the 3rd micropin group 26
On barb 2626 can be set to engage with the hole 102 on substrate 10.In an embodiment, the first thin slice 262 of the 3rd micropin group 26
It can be set on edge and lead the slot 104 that handle 2628 is inserted on substrate 10, be electrically connected by circuit and conductive column 25.
One embodiment of the invention, the micropin of the first micropin group 22, the second micropin group 24 and the 3rd micropin group 26 is by punching
Pressure or etch process are formed.The material of those burs is selected from stainless steel, nickel, nickel alloy, titanium, titanium alloy, carbon nanotubes or silicon material
Material, and in metal of the surface deposition with bio-compatibility.The material of those burs can also be resin be, for example, makrolon,
Polymethacrylic acid copolymer, ethylene/vinyl acetate copolymer, Teflon（Polytetrafluoroethylene (PTFE)）Or polyesters, and in surface
Metal of the deposition with bio-compatibility.The height of those burs is 300-600 microns, base widths are 150-450 microns.Should
The point of a little burs at intervals of 500-3000 microns.
Please refer to Fig.4 to Fig. 7.Fig. 4 is the structure partial top view of one embodiment of the invention working electrode micropin group.The
One micropin group 22 is formed by the first thin slice 222 and the second thin slice 224 are stacked, and one first perforation is at least set on the first thin slice 222
2222, the first 2222 edges of perforation, which are provided with one first bur 2224, and the second thin slice 224, at least sets one second perforation
2242, the second perforated edge is provided with one second bur 2244, and the second bur 2244 passes through relative position on the first thin slice 222
First perforation 2222 is opposite with the first bur 2224.
Fig. 5 is the structure partial top view of another embodiment of the present invention working electrode micropin group.First micropin group 22 by
First thin slice 222, the second thin slice 224 and the 3rd thin slice 226 are stacked to be formed, and the first perforation is at least set on the first thin slice 222
2222, the first 2222 edges of perforation are provided with one first bur 2224, and one second perforation is at least set on the second thin slice 224
2242, the second 2242 edges of perforation are provided with one second bur 2244, and one the 3rd perforation is at least set on the 3rd thin slice 226
2262, the 3rd 2262 edges of perforation are provided with one the 3rd bur 2264, and the second bur 2244 and the 3rd bur 2264 pass through first
The first perforation 2222 and the first bur 2224 on thin slice 222 are in positive triangle taper.
Fig. 6 is the structure partial top view of another embodiment of the present invention working electrode micropin group.First micropin group 22 by
First thin slice 222, the second thin slice 224, the 3rd thin slice 226 are stacked to be formed, wherein at least setting one first to wear on the first thin slice 222
Hole 2222, the first 2222 edges of perforation are provided with one first bur 2224；One second perforation is at least set on the second thin slice 224
2242, the second 2242 edges of perforation are provided with one second bur 2244；And the 3rd at least set one the 3rd perforation on thin slice 226
2262, the 3rd 2262 edges of perforation are provided with one the 3rd bur 2264, by the second bur 2244 and the 3rd bur 2264 through the
The first perforation 2222 and 2224 arranged adjacent of the first bur on one thin slice 222, in isosceles right angle trigonometry taper.
Fig. 7 is the structure partial top view of the still another embodiment working electrode micropin group of the present invention.First micropin group 22
Formed by the first thin slice 222, the second thin slice 224, the 3rd thin slice 226 and the 4th thin slice 228 are stacked, on the first thin slice 222 at least
One first perforation 2222 is set, and the first 2222 edges of perforation are provided with one first bur 2224, are at least set on the second thin slice 224
One second perforation 2242, the second 2242 edges of perforation are provided with one second bur 2244, one the are at least set on the 3rd thin slice 226
Three perforation 2262, the 3rd 2262 edges of perforation, which are provided with one the 3rd bur 2264 and the 4th thin slice 228, at least sets one the 4th
Perforation 2282, the 4th 2282 edges of perforation are provided with one the 4th bur 2284, the second bur 2244, the 3rd bur 2264 and the 4th
Bur 2284 through the first perforation 2222 on the first thin slice 222 and the first bur 2224 be in corner taper.
In four embodiments shown in Fig. 4 to Fig. 7, each bur 2224 of the first micropin group 22 includes a point 2221
And a substrate 2223, wherein the shape after the bur of the perforated edge of relative position on remaining thin slice passes through of the perforation on a thin slice
Into the micropin those points top not in sustained height.Alternatively, order that can be overlapping according to those thin slices, in advance
The height of its bur is designed, wears bur of the perforation through the perforated edge of relative position on remaining thin slice wherein on a thin slice
The top of those points of the micropin formed later has sustained height.
Then, Fig. 8 and Fig. 9 be refer to.Fig. 8 is that continuously percutaneous micropin monitors outside the combination of system one embodiment of the invention
See schematic diagram.Fig. 9 is that continuously percutaneous micropin monitors the combination diagrammatic cross-section of system to one embodiment of the invention.In the present embodiment
The first micropin group 22 formed by the first thin slice 222 and the second thin slice 224 are stacked, can for example apply a stamping press in the first thin slice
222 and second thin slice 224 surrounding with combine both.Second micropin group 24 has the first thin slice 242.3rd micropin group 26
Only there is the first thin slice 262.Since the present invention has a flexible gasket 30, during operation can with the muscle profile syntype of user,
It is in close contact.
Then, the partial cutaway schematic that 0, Figure 10 is Fig. 9 is please referred to Fig.1, wherein sensing macromolecule is coated on micropin
On bur.Specifically, sensing macromolecule is coated on the inner surface of bur, and anti-skin allergy is coated with the outer surface of bur
Medicine.In the present embodiment, sensing macromolecule is, for example, antibody, aptamer, restructuring monomer (ScFv), carbohydrate, glucose oxidase
（Glucose Oxidase）Or hydroxybutyric dehydrogenase（HBHD）.One surface scribbles the continuous warp of the high molecular micropin of sensing
Skin micropin monitors system, can be used to the concentration of target molecules in detection skin surface, and this concentration can be used as and judge physiological status
One of index.
Figure 11 is the partial cutaway schematic of Fig. 9, wherein sensing macromolecule is coated on test-paper.The present embodiment and Figure 10
The difference of illustrated embodiment is, the instrument of the first micropin group 22 of the present embodiment as extraction interstitial fluid, is not applied on bur
Cloth senses macromolecule, and sensing macromolecule is coated on the surface of the test-paper of the lower section of the first micropin group 22.In the present embodiment,
Test-paper is placed between the first micropin group 22 and substrate 10, and test-paper includes a conductive layer 92 and more on conductive layer 92
A test zone 94, coating sensing macromolecule on those test zones 94, and align with the perforation 2222 in the first micropin group 22.
The present embodiment defines those test zones 94 thereon using resin sheet 96.In addition, the first micropin group 22 is by an adhesion layer
98 with test paper chip bonding., can be in sensing high score in order to avoid the medicine of sensing macromolecule or anti-skin allergy is subject to environmental pollution
A protective layer is formed on the surface of the medicine of sub or anti-skin allergy, protective layer is, for example, epoxy resin-Polyurethane formyl tree
Fat（Epoxy-PU）Film.
Then, please refer to Fig.1 2, Figure 12 be one embodiment of the invention continuously percutaneous micropin monitor system combination it is local
Diagrammatic cross-section.In the present embodiment, lead handle 2248 and be directly electrically connected through part bending with the contact 42 on circuit board 40, without
Use conductive column.
Certainly, the present invention can also have other various embodiments, ripe in the case of without departing substantially from spirit of the invention and its essence
Various corresponding changes and deformation, but these corresponding changes and deformation can be made according to the present invention by knowing those skilled in the art
The protection domain of the claims in the present invention should all be belonged to.
Claims (13)
- A kind of 1. continuous percutaneous micropin monitoring system, it is characterised in that including:One substrate；One microneedle unit, including at least the one first micropin group and one second micropin group being arranged on the substrate, first micropin Group is used as working electrode, and the second micropin group is as electrode is referred to, and each micropin group includes at least a micropin, the first micropin group Comprising at least two thin slices, a perforation is at least set on each thin slice, which is provided with a bur, wherein on a thin slice Perforation is passed through for the bur of the perforated edge of relative position on remaining thin slice, and the bur is disconnected from each other；One signal processing unit, is arranged on the substrate and is electrically connected with the first micropin group and the second micropin group；One power supply unit, supply working power give the monitoring system；AndOne the 3rd micropin group is as counterelectrode.
- 2. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that the first micropin group is thin by one first Piece and one second thin slice are stacked and form, and one first perforation is at least set on first thin slice, which is provided with one One second perforation is at least set on the first bur, and second thin slice, which is provided with one second bur, this First perforation of two burs through relative position on first thin slice is opposite with first bur.
- 3. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that the first micropin group is thin by one first Piece, one second thin slice and one the 3rd thin slice are stacked and form, and one first perforation, first punching edge are at least set on first thin slice Edge is provided with one first bur, and one second perforation is at least set on second thin slice, which is provided with one second One the 3rd perforation is at least set on bur, and the 3rd thin slice, and the 3rd perforated edge is provided with one the 3rd bur, this is second prominent Thorn and the 3rd bur through first perforation on first thin slice and first bur be in triangular pyramidal.
- 4. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that the first micropin group is thin by one first Piece, one second thin slice, one the 3rd thin slice and one the 4th thin slice are stacked and form, and one first perforation is at least set on first thin slice, First perforated edge is provided with one first bur, and one second perforation, second perforated edge are at least set on second thin slice One second bur is provided with, one the 3rd perforation is at least set on the 3rd thin slice, and it is prominent that the 3rd perforated edge is provided with one the 3rd One the 4th perforation is at least set in thorn and the 4th thin slice, the 4th perforated edge is provided with one the 4th bur, second bur, 3rd bur and the 4th bur through first perforation on first thin slice and first bur be in corner taper.
- 5. continuous percutaneous micropin monitoring system according to any one of claims 1 to 4, it is characterised in that first micropin Each bur of group includes a point and a substrate, wherein perforation on a thin slice is worn through relative position on remaining thin slice The top of the point for the micropin that the bur of bore edges is formed after passing through is not in sustained height.
- 6. continuous percutaneous micropin monitoring system according to any one of claims 1 to 4, it is characterised in that first micropin Each bur of group includes a point and a substrate, wherein perforation on a thin slice is worn through relative position on remaining thin slice The top of the point for the micropin that the bur of bore edges is formed after passing through has sustained height.
- 7. micropin monitoring system as claimed in claim 1 continuous percutaneous, it is characterised in that the first micropin group and this is second micro- The micropin of pin group is formed by punching press or etch process.
- 8. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that scribbled on the inner surface of the bur Sense macromolecule.
- 9. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that scribbled on the outer surface of the bur The medicine of anti-skin allergy.
- 10. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that further include a test-paper, be placed in Between the first micropin group and the substrate, which includes a conductive layer and multiple test sections on the conductive layerDomain, coating sensing macromolecule on the test zone, and align with the perforation in the first micropin group.
- 11. the continuous percutaneous micropin monitoring system as any one of claim 8 to 10, it is characterised in that further include one Protective layer is formed on the medicine of sensing macromolecule or anti-skin allergy.
- 12. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that the material of the bur is selected from not Become rusty steel, nickel, nickel alloy, titanium, titanium alloy, carbon nanotubes or silicon materials, and in metal of the surface deposition with bio-compatibility.
- 13. continuous percutaneous micropin monitoring system as claimed in claim 1, it is characterised in that the material of the bur is resin, And in metal of the surface deposition with bio-compatibility.
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| TWI730504B (en) * | 2019-11-19 | 2021-06-11 | 奇異平台股份有限公司 | Percutaneous microneedle monitoring system |
| US20220008007A1 (en) * | 2020-07-13 | 2022-01-13 | Icreate Technology (Zhuhai) Co., Ltd. | Microneedle array and sensor including the same |
| CN115227254B (en) * | 2022-07-25 | 2024-06-25 | 武汉衷华脑机融合科技发展有限公司 | Composite microneedle structure and nerve microelectrode |
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| CN102264429A (en) * | 2008-12-26 | 2011-11-30 | 久光制药株式会社 | microneedle device |
| TWM427950U (en) * | 2011-09-23 | 2012-05-01 | Univ Nat Taipei Technology | Transdermal sensor |
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| EP1416980A2 (en) * | 1999-12-30 | 2004-05-12 | Redeon, Inc. | Stacked microneedle systems |
| AU2004291040A1 (en) * | 2003-11-13 | 2005-06-02 | Alza Corporation | System and method for transdermal delivery |
| US7785301B2 (en) * | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
| US8588884B2 (en) * | 2010-05-28 | 2013-11-19 | Emkinetics, Inc. | Microneedle electrode |
| CN104970805B (en) * | 2014-04-01 | 2017-09-29 | 微凸科技股份有限公司 | Percutaneous microneedle array patch and its manufacture method |
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| CN102264429A (en) * | 2008-12-26 | 2011-11-30 | 久光制药株式会社 | microneedle device |
| TWM427950U (en) * | 2011-09-23 | 2012-05-01 | Univ Nat Taipei Technology | Transdermal sensor |
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