CN104962454B - Full-automatic nucleic acid molecular cross instrument - Google Patents
Full-automatic nucleic acid molecular cross instrument Download PDFInfo
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- CN104962454B CN104962454B CN201510343431.2A CN201510343431A CN104962454B CN 104962454 B CN104962454 B CN 104962454B CN 201510343431 A CN201510343431 A CN 201510343431A CN 104962454 B CN104962454 B CN 104962454B
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
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Abstract
The invention discloses a kind of full-automatic nucleic acid molecular cross instrument, it is characterised in that including casing, circuit control module, hybridization platform, three-dimensional movement platform, multi-channel loading piston apparatus, Tip heads and can touch screen monitor.Advantages of the present invention：1. crossover process is full-automatic, without the need for manual operations, saves labour, shortens experimental period, reduces experimentation human factor mistake；2. three-dimensional movement platform is adopted, quick shift position, mobile accuracy are high, accurate；3. many person-portion experiments can be carried out simultaneously, cross-infection can be avoided again, shorten experimental period；4. Tip heads are divided to size two classes as needed, and big Tip heads are designed using big pipette, and continuous 5 times accurate sample-addings can be once realized in absorption, are simplified experimentation, are shortened experimental period.
Description
Technical field
The present invention relates to medical biological field, specifically a kind of full-automatic nucleic acid molecular cross instrument.
Background technology
Hybridization refers to the former bar single nucleic acid strands with certain homology under certain conditions（Suitable
Greenhouse degree and ionic strength etc.）Double-strand can be formed by base complementrity.The both sides of hybridization are determined nucleic acid sequence and probe, core to be measured
Acid sequence can be the genomic DNA and cell total rna that the gene of clone levies section, or non-cloning.Nucleic acid probe is
Refer to radionuclide, biotin or other active material marks, complementary specificity can occur with specific nucleotide sequence
Known dna or RNA fragments.CDNA probes, genomic probe, oligonucleotide probe, RNA can be divided into according to its source and property to visit
Pin etc..
Existing nucleic acid molecular cross instrument is to coordinate apparatus control with manual operations mostly, it is impossible to realize that full automation hybridizes,
There are problems that artificial complex operation, loaded down with trivial details, hybridization time it is long, it is easy generation human factor error and.
The content of the invention
To solve the above problems, the invention provides a kind of full-automatic nucleic acid molecular cross instrument.
A kind of full-automatic nucleic acid molecular cross instrument, it is characterised in that including casing, circuit control module, hybridization platform, three
Maintenance and operation moving platform, multi-channel loading piston apparatus, Tip heads and can touch screen monitor；
--- the casing as frame, hybridization platform, circuit control module, can touch screen monitor be arranged on casing；
--- the circuit control module and three-dimensional movement platform, multi-channel loading piston apparatus, hybridization platform, can touch screen
Monitor connects, and controls which and be operated；
--- the hybridization platform is used to deposit hybridization sample, Tip heads and various hybridization solutions（Entered with the temperature for providing suitable
Row hybrid experiment, is the place of hybrid experiment）；
--- the three-dimensional movement platform is arranged on hybridization platform, three-dimensional movement platform connecting multi-channel sample-adding piston dress
Put, circuit control module controls three-dimensional movement platform movement so as to mobile multi-channel loading piston apparatus；
--- the multi-channel loading piston apparatus be arranged on three-dimensional movement platform on, and by three-dimensional movement platform control into
Row transverse movement and lengthwise movement；Multi-channel loading piston apparatus are used to load and unload Tip heads, and draw and discharge liquid；
--- the Tip heads have big Tip heads and little Tip heads, the big Tip heads and little Tip heads to be respectively big specification and little
The Tip heads of specification；（Liquid is drawn and is discharged in experimentation, automates whole experiment process, without the need for manual operations；Greatly
Tip heads are drawn and can once realize continuous 5 times accurate sample-addings, greatly shorten loading time, simplify sample-adding process, shorten whole miscellaneous
Hand over the time of experiment）
--- it is described can touch screen monitor provide man-machine interface, by software so that by circuit control module control hybridization
Process simultaneously obtains hybrid experiment result.
Above-mentioned three-dimensional movement platform concrete structure is preferably：By the X-axis track, Y-axis track and Z axis track that can be mutually shifted
Composition is sequentially connected, X-axis track is erected on casing；Motor pinboard is installed on Z axis track, is provided with motor pinboard
Motor, motor drive leading screw and Z axis track to form relative up and down motion by the rotation of belt, multi-channel loading piston apparatus by
Screw mandrel drives and carries out lengthwise movement（X-axis track, Y-axis track and Z axis track can adopt conventional belt composition to arrange, and with electricity
Road control module connection, control Y-axis track are moved on X-axis track, and Z axis track is moved on Y-axis track, and here is no longer gone to live in the household of one's in-laws on getting married
State）.
Above-mentioned multi-channel loading piston apparatus concrete structure is preferably：It is made up of two covering device of big valve piston, big piston dress
The big Tip heads of handling are put, valve piston device loads and unloads little Tip heads；Size piston apparatus structure is specific as follows：
--- big piston apparatus, it is connected with the leading screw of three-dimensional movement platform Z axis track by pinboard by big bracket cage；Greatly
Motor support plate is installed on bracket cage top, is provided with motor and leading screw on the supporting plate, and motor passes through belt drive guide screw movement；Silk
Connecting connector under bar, connector are arranged below cylindrical guide, big piston rod, be provided with guide pillar and connect with valve piston device on the outside of connector
Connect, under big piston rod, connect big Tip heads installing pipe；The bottom of big bracket cage is installed by big piston sleeve, cylindrical guide, big piston rod quilt
It is enclosed within big piston sleeve, big piston rod is connected in big piston sleeve corresponding sealing ring, constitutes with big Tip heads installing pipe big
Piston structure；
--- valve piston device is main body by Small bracket frame, is inside set on rail slider equipped with valve piston fixed block, valve piston
Fixed block is connected with the guide pillar of big piston apparatus（To realize being synchronized with the movement）；Guide rail and little work are provided with below valve piston fixed block
Stopper rod, small piston rod pass through piston gasket and sealing ring to connect, and constitute valve piston structure with little Tip heads installing pipe, are enclosed in
In valve piston sleeve；
--- it is folded between big piston apparatus and valve piston device and lays down Tip head devices；Tip head devices are laid down by L-type
Big Tip heads unload plate and the little Tip heads of the L-type opposite with which unload plate composition, two are unloaded plate and are respectively provided with hole clipping, with respective Tip heads
Installing pipe position correspondence（Tip heads installing pipe moves up and down in corresponding hole clipping position）；Two are provided with the side of big piston sleeve
The bail of individual protrusion, big Tip heads are unloaded, at the big bracket cage above bail
A spring is hung, the spring other end hangs and connects big Tip heads and unload plate, and big Tip heads unload the vertical draw-in groove of plate and are enclosed within bail.
The present invention structure setting can realize full-automatic nucleic acid molecular hybridization experiments, by can touch screen monitor operate it is soft
Part sends operational order to circuit control module, and circuit control module control three-dimensional movement platform movement, three-dimensional movement platform are moved
It is dynamic to drive the movement of multi-channel loading piston apparatus, multi-channel loading piston apparatus handling Tip heads simultaneously to control the absorption of Tip heads and discharge
Liquid, so as to carry out hybrid experiment.Hybridization platform is used to deposit hybridization sample and hybridization liquid, there is provided suitable temperature carries out miscellaneous
Hand over experiment.Whole crossover process is full-automatic, without the need for manual operations.
Advantages of the present invention：1. crossover process is full-automatic, without the need for manual operations, saves labour, shortens experimental period,
Reduce experimentation human factor mistake；2. three-dimensional movement platform is adopted, quick shift position, mobile accuracy are high, accurate；3. may be used
Carry out many person-portion experiments simultaneously, cross-infection can be avoided again, shorten experimental period；4. Tip heads are divided to size two classes as needed, greatly
Tip heads are designed using big pipette, and continuous 5 times accurate sample-addings can be once realized in absorption, simplify experimentation, when shortening experiment
Between.
Description of the drawings
Fig. 1 is the structural representation of hybridization instrument of the present invention.
Fig. 2 is the structural representation of three-dimensional movement platform.
Fig. 3 is the structure decomposition figure of multi-channel loading piston apparatus.
Fig. 4 is the structure decomposition figure of valve piston device（Eliminate the decorative outer frame in Fig. 3）.
Fig. 5 is the structural representation that big Tip heads unload plate（It is not same angle that plate is unloaded with the big Tip heads in Fig. 3）.
Fig. 6-Figure 14 is the structural representation of the device motion process of the present invention.
For ease of illustrating, the same structure in above-mentioned accompanying drawing non-fully corresponding ratio draws；Fig. 6-Figure 14 is attached with other
Construction profile in figure is simultaneously differed, and is only to draw schematic configuration for explaining multi-channel loading piston apparatus motion process.
Reference：1 --- circuit control module；2 --- three-dimensional movement platform；3 --- multi-channel loading piston apparatus；
4 --- Tip heads；5 --- can touch screen monitor；6 --- hybridization platform；7 --- casing；8 --- X-axis track；9 --- Y-axis rail
Road；10 --- Z axis track；11 --- motor pinboard；12 --- the motor of three-dimensional movement platform；13 --- three-dimensional movement platform
Leading screw；14 --- big bracket cage；15 --- pinboard；16 --- motor support plate；17 --- the motor of big piston apparatus；
18 --- the leading screw of big piston apparatus；19 --- belt；20 --- connector；21 --- cylindrical guide；22 --- big piston rod；
23 --- guide pillar；24 --- big Tip head installing pipes；25 --- big piston sleeve；26 --- big Tip heads；27 --- Small bracket frame；
28 --- rail slider；29 --- valve piston fixed block；30 --- guide rail；31 --- the sealing ring of big piston apparatus；32——
Little Tip heads unload the hole clipping of plate；33 --- small piston rod；34 --- sealing gasket；35 --- the sealing ring of valve piston device；36——
Valve piston sleeve；37 --- little Tip heads installing pipe；38 --- big Tip heads unload plate；39 --- little Tip heads unload plate；40 --- it is big
Tip heads unload the hole clipping of plate；41 --- bail；42 --- draw-in groove；43 --- spring；44 --- the decorative outer frame of valve piston device
44。
Specific embodiment
The present invention will be described in detail by the following examples.
Full-automatic nucleic acid molecular cross instrument, including casing, circuit control module, hybridization platform, three-dimensional movement platform, lead to more
Road sample-adding piston apparatus, Tip heads and can touch screen monitor；
--- the casing as frame, hybridization platform, circuit control module, can touch screen monitor be arranged on casing；
--- the circuit control module and three-dimensional movement platform, multi-channel loading piston apparatus, hybridization platform, can touch screen
Monitor connects, and controls which and be operated；
--- the hybridization platform is used to deposit hybridization sample, Tip heads and various hybridization solutions（Entered with the temperature for providing suitable
Row hybrid experiment, is the place of hybrid experiment）；
--- the three-dimensional movement platform is arranged on hybridization platform, three-dimensional movement platform connecting multi-channel sample-adding piston dress
Put, circuit control module controls three-dimensional movement platform movement so as to mobile multi-channel loading piston apparatus；
Above-mentioned three-dimensional movement platform concrete structure is：By the X-axis track, Y-axis track and Z axis track that can be mutually shifted successively
Connection composition, X-axis track are erected on casing；Motor pinboard is installed on Z axis track, electricity is provided with motor pinboard
Machine, motor drive leading screw and Z axis track to form relative up and down motion by the rotation of belt, and multi-channel loading piston apparatus are by silk
Bar drives and carries out lengthwise movement；
--- the multi-channel loading piston apparatus be arranged on three-dimensional movement platform on, and by three-dimensional movement platform control into
Row transverse movement and lengthwise movement；Multi-channel loading piston apparatus are used to load and unload Tip heads, and draw and discharge liquid；
Above-mentioned multi-channel loading piston apparatus concrete structure is：It is made up of two covering device of big valve piston, big piston apparatus dress
Big Tip heads are unloaded, valve piston device loads and unloads little Tip heads；Size piston apparatus structure is specific as follows：
Big piston apparatus, are connected with the leading screw of three-dimensional movement platform Z axis track by pinboard by big bracket cage；Big bracket
Motor support plate is installed on frame top, is provided with motor and leading screw on the supporting plate, and motor passes through belt drive guide screw movement；Under screw mandrel
Connecting connector, connector are arranged below cylindrical guide, big piston rod, be provided with guide pillar and be connected with valve piston device on the outside of connector,
Big Tip heads installing pipe is connect under big piston rod；The bottom of big bracket cage is installed by big piston sleeve, cylindrical guide, big piston rod quilt cover
In big piston sleeve, big piston rod is connected in big piston sleeve corresponding sealing ring, constitutes with big Tip heads installing pipe big living
Plug structure；
Valve piston device is main body by Small bracket frame, is inside set equipped with valve piston fixed block on rail slider, and valve piston is fixed
Block is connected with the guide pillar of big piston apparatus；Guide rail and small piston rod are provided with below valve piston fixed block, small piston rod is through work
Plug sealing gasket and sealing ring connection, constitute valve piston structure with little Tip heads installing pipe, are enclosed in valve piston sleeve；
It is folded between big piston apparatus and valve piston device and lays down Tip head devices；Tip head devices are laid down by the big of L-type
Tip heads unload plate and the little Tip heads of the L-type opposite with which unload plate composition, and two are unloaded plate and are respectively provided with hole clipping, are installed with respective Tip heads
Pipe position correspondence；The bail of two protrusions is provided with the side of big piston sleeve, big Tip heads are unloaded
The vertical draw-in groove answered, has hung a spring at the big bracket cage above bail, and the spring other end hangs and connects big Tip heads and unload plate, greatly
Tip heads unload the vertical draw-in groove of plate and are enclosed within bail.
--- the Tip heads have big Tip heads and little Tip heads, the big Tip heads and little Tip heads to be respectively big specification and little
The Tip heads of specification；
--- it is described can touch screen monitor provide man-machine interface, by software so that by circuit control module control hybridization
Process simultaneously obtains hybrid experiment result.
For ease of understanding the present embodiment, the device motion process step of the present embodiment described briefly below：
1. by Tip heads and experiment needed for hybridization solution be placed in hybridization platform on predeterminated position on, then can touch screen monitoring
Operate on device, further three-dimensional movement platform is controlled by software through circuit control module, multi-channel loading piston apparatus are carried out
Transverse movement is to above Tip heads；
2. big Tip heads to be such as used, then the big Tip heads installing pipe of big piston apparatus is moved on alignment hybridization platform
Big Tip heads, then circuit control module start the motor on Z axis track, motor drives multi-channel loading piston to fill by leading screw
Put and move downwardly to certain altitude；
3. the motor on big piston apparatus is started, and motor drives leading screw to rotate down, and then promotes connector, drives big
Piston rod is pushed down in big Tip heads installing pipe, until shifting big Tip heads onto installs pipe end；Leading screw continues to rotate down, greatly
Piston rod promotes big Tip heads installing pipe, drives whole big piston structure to continue to move downward along guide rail, big Tip heads installing pipe
The hole clipping of plate is unloaded through big Tip heads, until big Tip heads installing pipe is downwardly into big Tip heads, completes Tip head processes are installed；
4. motor is inverted, and the big Tip heads installing pipe for inserting big Tip heads moves up to certain altitude；
5. multi-channel loading piston apparatus are laterally moved to above hybridization solution, and then motor continues the motion of step 2
Direction, until in big Tip heads insertion hybridization solution；
6. start the motor on big piston apparatus, motor drives leading screw to be rotated up, and then band follower link, drive big living
Stopper rod is moved in big Tip heads installing pipe upwards, and formation vacuum drawn hybridization solution is in big Tip heads（Now big piston rod movement
To big Tip heads installing pipe top）, complete imbibition process；
7. identical with step 4, motor is inverted, the big Tip heads installing pipe for inserting big Tip heads moves up to certain altitude；
8. multi-channel loading piston apparatus are laterally moved to above reative cell, and then motor continues the motion of step 2
Direction, until in the specified altitude assignment of big Tip heads intercalation reaction room；
9. the motor on big piston apparatus is started, and motor drives leading screw to rotate down, and then promotes connector, drives big
Piston rod is pushed down in big Tip heads installing pipe, until shifting big Tip heads onto installs pipe end, by the hybridization solution in big Tip heads
Reative cell is released into, completes to discharge liquid process；
10. identical with step 4, motor is inverted, the big Tip heads installing pipe for inserting big Tip heads moves up to certain height
Degree；
11. multi-channel loading piston apparatus are laterally moved to above the discarded box of Tip heads, and then motor drives leading screw
It is rotated up, and then band follower link, drive big piston rod to move up to big Tip heads installing pipe in big Tip heads installing pipe
Behind top, continue up, big Tip heads installing pipe wears back the hole clipping that big Tip heads unload plate, big Tip heads installing pipe grafting it is big
Tip heads are hindered by hole clipping, depart from big Tip heads installing pipe, are fallen in the discarded box of Tip heads, are completed to lay down Tip head processes.
This motion process is shown in accompanying drawing 6-14 successively：
Athletic performance represented by accompanying drawing 6-14 is as follows：
Fig. 6 is big piston rod original position in the big Tip heads installing pipe in step 3；
Fig. 7 shifts big Tip heads onto for big piston rod in step 3 and installs pipe end；
Fig. 8 unloads the hole clipping of plate for big Tip heads installing pipe in step 3 through big Tip heads；
Fig. 9 is downwardly into big Tip heads for big Tip head installing pipes in step 3；
Figure 10 is moved in big Tip heads installing pipe upwards for big piston rod in step 6, forms vacuum drawn hybridization solution in big
In Tip heads；
Figure 11 is pushed down in big Tip heads installing pipe for big piston rod in step 9, until shifting big Tip heads installing pipe onto
Hybridization solution in big Tip heads is released into reative cell by end；
During Figure 12 is step 11, big piston rod moves up to big Tip heads installing pipe top in big Tip heads installing pipe；
During Figure 13 is step 11, big piston rod is continued up, and is driven big Tip heads installing pipe to wear back big Tip heads and is unloaded plate
Hole clipping；
During Figure 14 is step 11, the big Tip heads of big Tip heads installing pipe grafting are hindered by hole clipping, are departed from big Tip heads and are installed
Pipe, drops.
In the same manner, under guide pillar of the valve piston device on the connector of big piston apparatus drives, also it is done in the same fashion
Motion.
Claims (1)
1. a kind of full-automatic nucleic acid molecular cross instrument, it is characterised in that including casing, circuit control module, hybridization platform, three-dimensional
Motion platform, multi-channel loading piston apparatus, Tip heads and can touch screen monitor；
--- the casing as frame, hybridization platform, circuit control module, can touch screen monitor be arranged on casing；
--- the circuit control module and three-dimensional movement platform, multi-channel loading piston apparatus, hybridization platform, can touch screen monitoring
Device connects, and controls which and be operated；
--- the hybridization platform is used to deposit hybridization sample, Tip heads and various hybridization solutions；
--- the three-dimensional movement platform is arranged on hybridization platform, three-dimensional movement platform connecting multi-channel sample-adding piston apparatus,
Circuit control module controls three-dimensional movement platform movement so as to mobile multi-channel loading piston apparatus；
Above-mentioned three-dimensional movement platform concrete structure is：It is sequentially connected by the X-axis track, Y-axis track and Z axis track that can be mutually shifted
Composition, X-axis track are erected on casing；Motor pinboard is installed on Z axis track, motor is provided with motor pinboard, electricity
Machine drives leading screw and Z axis track to form relative up and down motion by the rotation of belt, and multi-channel loading piston apparatus are by screw mandrel band
It is dynamic to carry out lengthwise movement；
--- the multi-channel loading piston apparatus are arranged in three-dimensional movement platform, and carry out horizontal stroke by three-dimensional movement platform control
To motion and lengthwise movement；Multi-channel loading piston apparatus are used to load and unload Tip heads, and draw and discharge liquid；
--- the Tip heads have big Tip heads and little Tip heads, the big Tip heads and little Tip heads to be respectively big specification and small dimension
Tip heads；
--- it is described can touch screen monitor man-machine interface is provided, by software and then crossover process controlled by circuit control module
And obtain hybrid experiment result；
Above-mentioned multi-channel loading piston apparatus concrete structure is：It is made up of two covering device of big valve piston, big piston apparatus handling are big
Tip heads, valve piston device load and unload little Tip heads；Size piston apparatus structure is specific as follows：
～～big piston apparatus, are connected with the leading screw of three-dimensional movement platform Z axis track by pinboard by big bracket cage；Big bracket
Motor support plate is installed on frame top, is provided with motor and leading screw on the supporting plate, and motor passes through belt drive guide screw movement；Under screw mandrel
Connecting connector, connector are arranged below cylindrical guide, big piston rod, be provided with guide pillar and be connected with valve piston device on the outside of connector,
Big Tip heads installing pipe is connect under big piston rod；The bottom of big bracket cage is installed by big piston sleeve, cylindrical guide, big piston rod quilt cover
In big piston sleeve, big piston rod is connected in big piston sleeve corresponding sealing ring, constitutes with big Tip heads installing pipe big living
Plug structure；
～～valve piston device is main body by Small bracket frame, is inside set equipped with valve piston fixed block on rail slider, and valve piston is fixed
Block is connected with the guide pillar of big piston apparatus；Guide rail and small piston rod are provided with below valve piston fixed block, small piston rod is through work
Plug sealing gasket and sealing ring connection, constitute valve piston structure with little Tip heads installing pipe, are enclosed in valve piston sleeve；
～～between big piston apparatus and valve piston device is folded with lays down Tip head devices；Tip head devices are laid down by the big of L-type
Tip heads unload plate and the little Tip heads of the L-type opposite with which unload plate composition, and two are unloaded plate and are respectively provided with hole clipping, are installed with respective Tip heads
Pipe position correspondence；The bail of two protrusions is provided with the side of big piston sleeve, big Tip heads are unloaded
The vertical draw-in groove answered, has hung a spring at the big bracket cage above bail, and the spring other end hangs and connects big Tip heads and unload plate, greatly
Tip heads unload the vertical draw-in groove of plate and are enclosed within bail.
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| CN201510343431.2A CN104962454B (en) | 2015-06-19 | 2015-06-19 | Full-automatic nucleic acid molecular cross instrument |
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| CN201510343431.2A CN104962454B (en) | 2015-06-19 | 2015-06-19 | Full-automatic nucleic acid molecular cross instrument |
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| CN107603873B (en) * | 2017-10-26 | 2023-07-14 | 广州安必平医药科技股份有限公司 | Molecular hybridization instrument and method of use thereof |
| CN107586707B (en) * | 2017-10-26 | 2020-04-17 | 广州安必平医药科技股份有限公司 | Control manipulator, molecular hybridization instrument and working method of control manipulator |
| CN116162745A (en) * | 2023-01-12 | 2023-05-26 | 广东凯普科技智造有限公司 | Control method and system for program component of nucleic acid molecule hybridization instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20030059823A1 (en) * | 2001-09-21 | 2003-03-27 | Juki Corporation | Hybridization apparatus and method for detecting nucleic acid in sample using the same |
| JP2005214797A (en) * | 2004-01-29 | 2005-08-11 | Canon Inc | Device for injecting specimen in biochip |
| CN201915086U (en) * | 2010-12-31 | 2011-08-03 | 福建泰普生物科学有限公司 | Nucleic acid hybridization oven |
| CN202681526U (en) * | 2012-06-19 | 2013-01-23 | 徐国平 | Foldable convenient clothes hanger |
| CN204824844U (en) * | 2015-06-19 | 2015-12-02 | 广东凯普生物科技股份有限公司 | Appearance is hybridized to full -automatic nucleic acid molecules |
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