CN104958383A - Traditional Chinese medicine for treating rheumatoid arthritis (RA) - Google Patents

Abstract

The invention belongs to the technical field of medicines and in particular relates to a traditional Chinese medicine for treating rheumatoid arthritis (RA). The traditional Chinese medicine comprises the following traditional Chinese medicines in parts by weight: 2-4 parts of manchurian wildginger herb, 5-13 parts of Chinese ligusticum rhizome, 5-13 parts of Siberian cocklour fruit, 8-16 parts of clematis root, 8-16 parts of common clubmoss herb, 8-16 parts of wooly datchmanspipe herb, 8-16 parts of fourstamen stephania root, 11-19 parts of mulberry twig, 8-16 parts of Chinese starjasmine stem, 2-4 parts of scorpion, 8-16 parts of suberect spatholobus stem, 5-13 parts of cowherb seed and 4-8 parts of liquorice root. The inflammatory indicator level of RA can be obviously reduced, the functions of joints and the X-ray stage can be improved and the curative effects are definite by adopting the traditional Chinese medicine.

Description

A kind of Chinese medicine for the treatment of rheumatoid arthritis

Technical field

The invention belongs to medical art, be specifically related to a kind of Chinese medicine for the treatment of rheumatoid arthritis.

Background technology

Rheumatoid arthritis (RA) is that a kind of antigen drives, cell-mediated and relevant to inherited genetic factors autoimmune disease, it is characterized in that chronic symmetry polyarthritis, gets involved the most common with both hands, wrist, knee joint, ankle and joints of foot.Patient can with extra-articular manifestations such as heating, anemia, subcutaneous nodule and lymphadenectasis.Multiple autoantibody can be had in serum to occur.Without correct rheumatoid arthritis Chang Fanfu protracted course of disease for the treatment of finally because bone erosion causes joint deformity and afunction.The sickness rate of rheumatoid arthritis is ten thousand, and prevalence is.China adjusts Check rheumatoid arthritis multiple in women through preliminary epidemiology.The ratio of men and women is 1:3, and can betide any age, onset peak in 30-50 year.

Although western medical treatment RA onset is very fast, can controls and relief of symptoms, delay disease progression, the obvious toxic and side effects of normal appearance; Chinese medicine determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs, adjustment body function, strengthens and while after treatment effect, side effect is less.

At present, need to find the Chinese medicine being exclusively used in treatment rheumatoid arthritis.

Summary of the invention

Technical problem to be solved by this invention avoids the weak point existing for above-mentioned prior art, a kind of Chinese medicine for the treatment of rheumatoid arthritis is provided, this Chinese medicine obviously can reduce the inflammatory parameters level of rheumatoid arthrosis, improves function of joint and x-ray by stages, determined curative effect.

The present invention is achieved through the following technical solutions:

Treat a Chinese medicine for rheumatoid arthritis, be made up of the Chinese medicine of following weight portion:

Herba Asari 2-4 part, Rhizoma Ligustici 5-13 part, Fructus Xanthii 5-13 part, Radix Clematidis 8-16 part, Herba Lycopodii 8-16 part, Herba Aristolochiae Mollissimae 8-16 part, Radix Stephaniae Tetrandrae 8-16 part, Ramulus Mori 11-19 part, Caulis Trachelospermi 8-16 part, Scorpio 2-4 part, Caulis Spatholobi 8-16 part, Semen Vaccariae 5-13 part, Radix Glycyrrhizae 4-8 part.

Preferably, the Chinese medicine of above-mentioned treatment rheumatoid arthritis, is made up of the Chinese medicine of following weight portion:

Herba Asari 2.5-3.5 part, Rhizoma Ligustici 7-11 part, Fructus Xanthii 7-11 part, Radix Clematidis 10-14 part, Herba Lycopodii 10-14 part, Herba Aristolochiae Mollissimae 10-14 part, Radix Stephaniae Tetrandrae 10-14 part, Ramulus Mori 13-17 part, Caulis Trachelospermi 10-14 part, Scorpio 2.5-3.5 part, Caulis Spatholobi 10-14 part, Semen Vaccariae 7-11 part, Radix Glycyrrhizae 5-7 part.

Preferred, the Chinese medicine of above-mentioned treatment rheumatoid arthritis, is made up of the Chinese medicine of following weight portion:

Herba Asari 3 parts, Rhizoma Ligustici 9 parts, Fructus Xanthii 9 parts, Radix Clematidis 12 parts, Herba Lycopodii 12 parts, Herba Aristolochiae Mollissimae 12 parts, Radix Stephaniae Tetrandrae 12 parts, Ramulus Mori 15 parts, Caulis Trachelospermi 12 parts, Scorpio 3 parts, Caulis Spatholobi 12 parts, Semen Vaccariae 9 parts, 6 parts, Radix Glycyrrhizae.

The ratio of above weight proportion is through that science screening obtains, and for especial patient, as serious symptom or mild, fat or modest patient, can the proportioning of amount of corresponding adjustment composition, and increase or reduce being no more than 100%, drug effect is substantially constant.

The weight portion of said medicine, if in units of part, the normally consumption of 1 dose.

The indication of Chinese medicine of the present invention: be used for the treatment of rheumatoid arthritis.

The taboo item of Chinese medicine of the present invention: the fasting for the treatment of period in a medicine is greasy, raw and cold, the smelling of fish or mutton, irritant and stodgy food.

The Chinese medicine related in prescriptions of Chinese medicine of the present invention all records in Chinese Pharmacopoeia 2010 editions.

Rheumatoid arthritis (RA) is thought in the traditional Chinese medical science and is belonged to arthromyodynia category.Chinese medicine thinks that positive QI-insufficiency is the basic reason of RA morbidity, and pathogen invasion is the essential condition of morbidity and pathogenic characteristic that deficiency in origin and excess in superficiality is.The generation of RA mainly due to positive QI-insufficiency, caused by the heresy experiencing wind, cold, wet, heat.Ferritic is weak, and positive QI-insufficiency, interspaces of skin and muscles being loose, weakened defensive QI is the intrinsic factor causing rheumatoid arthritis.Exopathogenic factor is the invasion and attack of the heresy such as wind, cold, wet, heat mainly.Because the circumfluence of rheumatoid arthritis QI and blood of a specified duration is smooth, can in the raw expectorant stasis of blood, the expectorant stasis of blood can be tied mutually, also can be harmonious with exopathogen, resistance amenorrhea network, dark people's bone marrow, and causes root and be deeply difficult to remove.Its etiology and pathogenesis substantially can be summarized as weakened body resistance, heresy is invaded, phlegm-turbidity and blood stasis blood, poison damage a network resistance aspect.

Applicant finds that the inclined Sheng of human body natural endowment negative and positive declines partially, the evil difference having wind and cold damp and hot of sense, and both influence each other, and can form simultaneous occurrence of cold and heat syndromes; Wrong treatment is controlled in mistake, or delay treatment, or makes pathogen more very, and healthy energy more declines, or makes pathogenic factor character have conversion, also can occur simultaneous occurrence of cold and heat syndromes.Therefore simultaneous occurrence of cold and heat syndromes is the common pattern of syndrome of rheumatoid arthritis.According to the feature very easily occurring phlegm-turbidity and blood stasis blood in primary disease pathogenesis and pathogenic process because of heresy resistance venation, the method for dispelling cold by warming the meridian, removing damp-heat, promoting blood circulation to remove obstruction in the collateral should be adopted to treat.

Its prescription mechanism of Chinese medicine of the present invention is as follows:

Monarch drug: Herba Asari, Rhizoma Ligustici, Fructus Xanthii merit are with dispelling cold by warming the meridian;

Ministerial drug: Radix Clematidis, Herba Lycopodii, Herba Aristolochiae Mollissimae merit are with wind-damp dispelling cold expelling; Radix Stephaniae Tetrandrae, Ramulus Mori, Caulis Trachelospermi merit are with expelling wind-damp and clearing heat.

Adjuvant drug: Scorpio, Caulis Spatholobi, Semen Vaccariae merit are with promoting blood circulation to remove obstruction in the collateral.

Ministerial drug: Radix Glycyrrhizae coordinating the actions of various ingredients in a prescription.

We's compatibility is reasonable, and all medicines share the effect of playing dispelling cold by warming the meridian, removing damp-heat, promoting blood circulation to remove obstruction in the collateral altogether, the pathogenesis of rheumatoid arthritis intermingling cold and heat of linking closely card, obviously can reduce the inflammatory parameters level of rheumatoid arthrosis, improve function of joint and x-ray by stages, determined curative effect, is worthy to be popularized.

Detailed description of the invention

Below in conjunction with specific embodiment, the present invention is further described, so that those skilled in the art more understands the present invention, but does not therefore limit the present invention.

Embodiment 1

Treat a Chinese medicine for rheumatoid arthritis, each crude drug weight proportion is as follows:

Herba Asari 4g, Rhizoma Ligustici 9g, Fructus Xanthii 9g, Radix Clematidis 12g, Herba Lycopodii 12g, Herba Aristolochiae Mollissimae 12g, Radix Stephaniae Tetrandrae 12g, Ramulus Mori 15g, Caulis Trachelospermi 12g, Scorpio 4g, Caulis Spatholobi 12g, Semen Vaccariae 9g, Radix Glycyrrhizae 6g.

Embodiment 2

Treat a Chinese medicine for rheumatoid arthritis, each crude drug weight proportion is as follows:

Herba Asari 2.5g, Rhizoma Ligustici 7g, Fructus Xanthii 11g, Radix Clematidis 10g, Herba Lycopodii 14g, Herba Aristolochiae Mollissimae 10g, Radix Stephaniae Tetrandrae 14g, Ramulus Mori 13g, Caulis Trachelospermi 14g, Scorpio 3.5g, Caulis Spatholobi 10g, Semen Vaccariae 11g, Radix Glycyrrhizae 5g.

Embodiment 3

Treat a Chinese medicine for rheumatoid arthritis, each crude drug weight proportion is as follows:

Herba Asari 3.5g, Rhizoma Ligustici 11g, Fructus Xanthii 7g, Radix Clematidis 14g, Herba Lycopodii 10g, Herba Aristolochiae Mollissimae 14g, Radix Stephaniae Tetrandrae 10g, Ramulus Mori 17g, Caulis Trachelospermi 10g, Scorpio 2.5g, Caulis Spatholobi 14g, Semen Vaccariae 7g, Radix Glycyrrhizae 7g.

Embodiment 4

Treat a Chinese medicine for rheumatoid arthritis, each crude drug weight proportion is as follows:

Herba Asari 2g, Rhizoma Ligustici 5g, Fructus Xanthii 13g, Radix Clematidis 8g, Herba Lycopodii 16g, Herba Aristolochiae Mollissimae 8g, Radix Stephaniae Tetrandrae 16g, Ramulus Mori 11g, Caulis Trachelospermi 16g, Scorpio 4g, Caulis Spatholobi 8g, Semen Vaccariae 13g, Radix Glycyrrhizae 4g.

Embodiment 5

Treat a Chinese medicine for rheumatoid arthritis, each crude drug weight proportion is as follows:

Herba Asari 4g, Rhizoma Ligustici 13g, Fructus Xanthii 5g, Radix Clematidis 16g, Herba Lycopodii 8g, Herba Aristolochiae Mollissimae 16g, Radix Stephaniae Tetrandrae 8g, Ramulus Mori 19g, Caulis Trachelospermi 8g, Scorpio 2g, Caulis Spatholobi 16g, Semen Vaccariae 5g, Radix Glycyrrhizae 8g.

Carried out clinical pharrnacokinetics test to Chinese medicine of the present invention, Details as Follows:

1. data and method

1.1 object of study

Choose 120 routine rheumatoid arthritis intermingling cold and heat card patients.

1.2 Western medicine diagnose standards

Meet the standard of Americanism damp disease academic year revision:

(1) refuse to budge morning continuous 1 hour (>=6 weeks).

(2) more than 3 or 3 arthroncuss (>=6 weeks) are had.

(3) wrist, the palm refer to and proximal interphalangeal joint swollen (>=6 weeks).

(4) symmetry swollen joint (>=6 weeks).

(5) subcutaneous nodule is had.

(6) hands line changes (having the narrow of osteoporosis and joint space at least).

(7) rheumatoid factor positive (titre >1:32).

Possessing above more than 4 or 4 persons all diagnosable is rheumatoid arthritis.

1.3 TCM syndrome diagnostic criteria

Meet the CM syndrome differentiation criterion of simultaneous occurrence of cold and heat syndromes: primary symptom: limbs joint red and swollen heat pain, the local skin touched is hot, though there is fever of the body, for lid clothing; Or whole body fear of cold, joint joint stuffiness, get Wen Zeshu; Morning is stiff.

Secondary disease: thirst with desire to drink, fatigue and weak, limbs are heavy.

Tongue arteries and veins red tongue tongue white or light red tongue yellow fur, wiry and frequent pulse or stringy and tense pulse.

1.4 inclusive criteria

1. meet doctor trained in Western medicine Diagnosis of Rheumatoid Arthritis standard, and meet the patient of traditional Chinese medical science simultaneous occurrence of cold and heat syndromes CM syndrome differentiation criterion simultaneously;

2. the age is between 18-65 years old, male or female;

3. informed consent, volunteers tested.

4. function of joint 1-3 level.

5. x-ray I-III phase by stages.

1.5 exclusion standard

(1) age year with 18 times or over-65s, gestation and the female patient of age of sucking;

(2) severe primary disease, the psychotics such as cardiovascular, cerebrovascular, liver, kidney and hemopoietic system is associated with;

(3) serious stomach or duodenal ulcer or rotten to the corn person is associated with;

(4) patient of severe joint deformity, afunction;

(5) other Patients with Rheumatic Diseases are associated with;

(6) the dialectical claimer of simultaneous occurrence of cold and heat syndromes is not met;

(7) arthrotrauma history person;

(8) to the not resistance to receptor of this medicine;

(9) function of joint 4 grades, the patient of x-ray IV phase;

1.6 Therapeutic Method

Give treatment by Chinese herbs of the present invention, prescription: Herba Asari 3g, Rhizoma Ligustici 9g, Fructus Xanthii 9g, Radix Clematidis 12g, Herba Lycopodii 12g, Herba Aristolochiae Mollissimae 12g, Radix Stephaniae Tetrandrae 12g, Ramulus Mori 15g, Caulis Trachelospermi 12g, Scorpio 3g, Caulis Spatholobi 12g, Semen Vaccariae 9g, Radix Glycyrrhizae 6g.Be decocted in water for oral dose, day potion, sooner or later sub-service was a course for the treatment of with 2 weeks.

1.7 observation index

1. hot, the aversion to cold in cardinal symptom arthralgia, arthroncus, stiff time in morning, joint, overcast and rainyly to increase the weight of, fatigue and weak, heating, thirsty etc.;

2. main physical signs arthroncus degree, articular pain degree, grip;

3. inflammatory parameters: ESR, RF, CRP, x-ray are by stages etc.;

5. respectively rheumatoid arthritis clinical symptoms and sign classification and scoring, Chinese medicine syndrome integral are evaluated before and after treatment.

1.8 traditional Chinese medical science sign curative effect determinate standards

1. clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%

2. effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%

3. effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%

4. invalid: tcm clinical practice symptom, sign are all not improved or increase the weight of, syndrome integral reduces <30%.

Computing formula: nimodipine method: integration x100% before (before treatment the rear integration of integration-treatment)/treatment.

1.9 statistical analysis technique

Using statistics software carries out analytic statistics analysis.Enumeration data adopts X2 inspection, and measurement data adopts t inspection, with P<0.05, ranked data Bian rank test, represents that difference has statistical significance.

2. result

Inflammatory parameters change before and after 2.1 treatments

Front and back inflammatory parameters change treated by table 1

Time	ESR	RF	CRP
				Before treatment	49.37±12.28	592.88±128.29	128.36±32.38
After treatment	11.29 ±2.21	93.98±23.37	24.27±12.25

After treatment, ESR, RF, CRP level is obviously improved before all comparatively treating, and difference has statistical significance (P<0.05); In table 1.

Before and after 2.2 treatments, function of joint classification and x-ray compare by stages

Treatment posterior joint functional classification and x-ray be all comparatively front obviously improvement for the treatment of by stages, and difference has statistical significance (P<0.05), in table 2.

2.3 TCM syndrome curative effects

120 routine patients, recovery from illness 65 example, effective 42 examples, effective 10 examples, invalid 3 examples, cure rate 54.2%, total obvious effective rate 89.2%, total effective rate 97.5%.

Claims (3)

1. treat a Chinese medicine for rheumatoid arthritis, be made up of the Chinese medicine of following weight portion:

Herba Asari 2-4 part, Rhizoma Ligustici 5-13 part, Fructus Xanthii 5-13 part, Radix Clematidis 8-16 part, Herba Lycopodii 8-16 part, Herba Aristolochiae Mollissimae 8-16 part, Radix Stephaniae Tetrandrae 8-16 part, Ramulus Mori 11-19 part, Caulis Trachelospermi 8-16 part, Scorpio 2-4 part, Caulis Spatholobi 8-16 part, Semen Vaccariae 5-13 part, Radix Glycyrrhizae 4-8 part.

2. the Chinese medicine for the treatment of rheumatoid arthritis according to claim 1, is characterized in that, is made up of the Chinese medicine of following weight portion:

Herba Asari 2.5-3.5 part, Rhizoma Ligustici 7-11 part, Fructus Xanthii 7-11 part, Radix Clematidis 10-14 part, Herba Lycopodii 10-14 part, Herba Aristolochiae Mollissimae 10-14 part, Radix Stephaniae Tetrandrae 10-14 part, Ramulus Mori 13-17 part, Caulis Trachelospermi 10-14 part, Scorpio 2.5-3.5 part, Caulis Spatholobi 10-14 part, Semen Vaccariae 7-11 part, Radix Glycyrrhizae 5-7 part.

3. the Chinese medicine for the treatment of rheumatoid arthritis according to claim 3, is characterized in that, is made up of the Chinese medicine of following weight portion:

Herba Asari 3 parts, Rhizoma Ligustici 9 parts, Fructus Xanthii 9 parts, Radix Clematidis 12 parts, Herba Lycopodii 12 parts, Herba Aristolochiae Mollissimae 12 parts, Radix Stephaniae Tetrandrae 12 parts, Ramulus Mori 15 parts, Caulis Trachelospermi 12 parts, Scorpio 3 parts, Caulis Spatholobi 12 parts, Semen Vaccariae 9 parts, 6 parts, Radix Glycyrrhizae.